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646jili com ATLANTA — The U.S. government’s premier research body has made an important discovery that could help create new drugs to lower “bad” cholesterol, and hopefully prevent heart attacks and stroke. But the interesting part of that story isn’t just the discovery itself, but the technology responsible for it: a relatively new type of microscope that essentially froze LDL cholesterol molecules, allowing researchers for the first time to get a detailed view of the structure of LDL and find new ways to approach stopping LDL buildup into body. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.Veer Bal Diwas 2024: PM Modi Calls For Equipping Youth With Skills In Emerging Technologies Like AI And Machine Learning; VIDEOManisha Malhotra Makes His Mark At IFFI 2024: Designer Reveals Why He Chose To Now Produce Movies Recommended Playlist Renowned Fashion Designer Rohit Bal No More; Passes Away Due To Prolonged Illness AR Rahman's 'Pre-Marriage Agreement' With Saira Banu Grabs Attention As Old Video Resurfaces Aishwarya Rai Celebrates Aaradhya's 13th Birthday, Throws A Party Sans Abhishek Bachchan Shah Rukh Khan Death Threat: Accused Stalked SRK's Family, Tracked Aryan Khan's Movements Top Bollywood Headlines, November 22, 2024: Amitabh Bachchan Celebrates Release Of 'I Want To Talk', Praises Son Abhishek Bachchan Diljit Dosanjh Explores 'City of Nawabs', Enjoys 'Makhan Malai' Ahead Of Lucknow Concert | WATCH Top Bollywood Headlines, November 21, 2024: Aishwarya Celebrates Aaradhya's Birthday Sans Abhishek; Diljit Dosanjh’s Epic Recovery After Stage Stumble From A Boy To A Man: Saqib Saleem On Citadel, Struggles & New-Found Confidence | EXCLUSIVE Top Viral Videos Diljit Dosanjh's Cool Comeback to 'Patiala Peg' Controversy Diljit Dosanjh addressed the ongoing criticism surrounding his hit song Patiala Peg during his concert in Lucknow. The Chamkila star responded by stating that singers are unfairly targeted for glorifying alcohol, especially in comparison to actors. He pointed out that alcohol in films receives little scrutiny, despite its frequent glamorization on-screen. Diljit's response was shared on his Instagram, where it quickly went viral. IFFI 2024: Amar Kaushik's Move From Horror To Mythology Finds Roots In Childhood Tales Imtiaz Ali At IFFI 2024: Women Power & Representation In Bollywood And The' Rockstar' Madness Diljit Dosanjh Explores 'City of Nawabs', Enjoys 'Makhan Malai' Ahead Of Lucknow Concert | WATCH Shah Rukh Khan Death Threat: Accused Stalked SRK's Family, Tracked Aryan Khan's Movements AR Rahman's 'Pre-Marriage Agreement' With Saira Banu Grabs Attention As Old Video Resurfaces Bollywood music composer AR Rahman and his wife Saira Banu have announced their separation after 29 years of marriage. The couple released a joint statement on November 19 revealing their decision. Amid big reactions from fans on unexpected split, an old clip of Rahman discussing his marriage has resurfaced. Watch- Aishwarya Rai Celebrates Aaradhya's 13th Birthday, Throws A Party Sans Abhishek Bachchan Kangana Ranaut Praises A Star Kid For A Change, Cheers For SRK's Son Aryan Khan Before Debut Liam Payne's Funeral Today, 'One Direction' Reunite After 9 Years For Painful Final Farewell AR Rahman Pens Separation Note With A Bizarre Sign-Off, Leaving Fans 'Disappointed' Fans Pay Heavy Price To Attend Diljit Dosanjh's Ahmedabad Concert Without Ticket | WATCH Diljit Dosanjh paused his Ahmedabad concert on noticing a crowd of ticketless fans. While fans got creative to attend their favourite's show, they did end up paying a heavy price for it. How? Watch video for details- Liam Payne's Funeral Finalised, Suspect Rogelio 'Roger' Nores Barred From Attending Private Ceremony Viral Video: Hania Aamir Attends Badshah's Dubai Concert, Rumoured Couple Sparks Social Media Frenzy Mukesh Khanna Blasts Paps At 'Shaktimaan' Event; Netizens Give Creative Take | WATCH Aamir Khan & Anees Bazmee's Chat On 'Bhool Bhulaiyaa 3' & 'Singham Again' Clash Goes Viral Zayn Malik Look-Alike Contest Disappoints Fans, 'ZSquad' Apologises For 'Failing' The Star Zayn Malik fans were not impressed by the verdict of a look-alike concert held in New York. Many expessed frustration over judges selecting the winner and runner-ups, despite the contestant looking 'barely' anything like Zayn. Watch- Diljit Dosanjh Calls For 'Dry Nation Movement' At Ahmedabad Show, Responds To Legal Notice Swara Bhasker Faces Social Media Backlash After Maulana Sajjad Nomani Meeting Diljit Dosanjh Receives Legal Notice Ahead Of Hyderabad Concert For 'These' Songs Liam Payne Faced Heartbreaking Ultimatum: Girlfriend Kate Cassidy Asks Him To Choose | WATCH Short Videos Priyanka Chopra's Hand Gestures Spark Curiosity SRK Avoids Fall During Wild Airport Scene Sonu Nigam Always Leaves Us In Awe With His Presence Hina Khan Stuns In A Pink Kashmiri Salwar Suit Kareena Kapoor's Birthday Bash: A Glimpse of Her Fabulous Gift and Cake Aditya Roy Kapur’s Drool-Worthy Transformation Wamiqa Gabbi's Bold Look Steals All the Spotlight Neil Nitin Mukesh’s Emotional Goodbye to Bappa with Final Aarti Jackie’s Ganpati Aarti Moment; You Won’t Believe What He Brings Along Siddhant & Raghav’s Bromance Related Articles Kareena Khan, Sonali Bendre, Manisha Koirala wish 'loveliest' Kajol on her 50th b'day Bobby Deol, Manisha Koirala express gratitude as 'Gupt' completes 27 years: 'The love has been endless' Salman Khan's 'Bajrangi Bhaijaan' co-star Harshaali Malhotra's enchanting rendition of Heeramandi's song takes the internet by strom When Mani Ratnam called Kajol for Dil Se and she thought it was a prank Did Nora Fatehi have a fallout with Karan Johar? Here's why fans feel so... Changing sports landscape in India: Women athletes are at forefront, notes Manisha Malhotra Today's Top 10 from ETimes Alia Bhatt, Ajay Devgn, Kajol, Abhishek Bachchan: Celebs arrive at Sidharth Malhotra, Kiara Advani's wedding reception in Mumbai MORE FROM E TIMES

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Carlos Santana returns to Cleveland on 1-year deal, first baseman's third stint with GuardiansDistt Admin Baramulla signs MoU with NHPC to improve healthcare servicesCLEVELAND (AP) — Even after leaving Cleveland, Carlos Santana remained a fan favorite and was warmly welcomed back as a visitor. He's home again. Santana signed a one-year, $12 million contract and returned Monday for his third stint with the Guardians, who have an opening at first base after the AL Central champions traded Josh Naylor to Arizona on Saturday. The 38-year-old Santana spent last season with Minnesota, batting .238 with 23 homers and 71 RBIs in 150 games. He also won his first Gold Glove, becoming the oldest position player to win the honor for the first time. Santana previously was with Cleveland from 2010-17. He returned in 2019, made his first All-Star team and spent two seasons with the club before signing as a free agent with the Kansas City Royals. The switch-hitter is second in club history in walks (881), tied for sixth in homers (216) and is eighth in extra-base hits (503). Over 15 major league seasons, Santana has 324 homers and 1,082 RBIs in 2,080 games. Santana has been remarkably consistent, driving in at least 60 runs and playing a minimum of 130 games in each of his 13 full seasons. He also has played for Philadelphia, Seattle, Pittsburgh and Milwaukee. The well-respected Santana will be Cleveland's primary first baseman in 2025 after the Guardians sent Naylor to the Diamondbacks for right-hander Slade Cecconi and a competitive balance draft pick. The Guardians have other options at first base, including Kyle Manzardo and Jhonkensy Noel. But there's no need to rush those players with Santana around, and it's entirely possible he could be signed beyond 2025. With the Naylor deal, the Guardians have completely overhauled the right side of their infield this winter. Cleveland previously traded Gold Glove second baseman Andrés Giménez to Toronto as part of a three-team swap with Pittsburgh. It feels somewhat risky — and maybe unnecessary — for an established team, but president of baseball operations Chris Antonetti was quick to point out that both Naylor and Giménez arrived in Cleveland via trades. “Very difficult trades,” he said. "In terms of how we have to operate moving forward, there are times when we have to make difficult decisions involving very good players, but our goal continues to be how do we find a way to field competitive teams both in the near term and long term and that sometimes necessitates difficult decisions. “To be clear, our goal in 2025 is to try to find a way to win the American League Central.” AP MLB: https://apnews.com

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Top officials at the Rugby Football Union have been accused of betraying and misleading the game by the former England international who has been helping to negotiate the sport’s future below the Premiership. Simon Halliday, part of England’s 1992 Five Nations grand slam-winning side, has also called for a review into the “significant” failings of some RFU executive directors. Halliday, who was chair of European Professional Club Rugby for seven years until 2021, has latterly been representing Championship clubs seeking greater funding and firm guarantees from the RFU over promotion and relegation. In an excoriating letter sent to the RFU’s chair, Tom Ilube, seen by the Observer , he alleges the existing tier 2 clubs “have been stalled, misled and misinformed” and warns recent poor governance “threatens the game” in England. In particular, Halliday alleges RFU executives have reneged on assurances given at a council meeting in mid-June to talk further about softening the Premiership minimum standards criteria to make it more feasible for sides to be promoted to the top tier. “With the help of our own legal advisers ... I made it quite clear that some matters were not agreed and needed further debate,” Halliday wrote. “This was signed off by the RFU executive and I have the written evidence, as well as that of our lawyer. Since then, we have been stalled, misled, misinformed and there is no sign of a more progressive approach to this fundamental part of the game.” A two-leg playoff between the Championship’s top side and the Premiership’s bottom team had been hailed as a means of retaining promotion and relegation. But a crucial tweak to the small print now requires sides lacking an existing ground with a capacity exceeding 10,000 to have advance planning permission and financial assurances in place guaranteeing their stadium expansion work will happen within four years, in effect leaving every Championship club, bar ninth-placed Doncaster, unable to go up. Halliday, who stepped down in August as chair of the Championship board, has urged Ilube either to “make a statement clarifying that promotion and relegation is dead” or to “conduct an immediate review” before the 1 December deadline for applying for a facilities audit. “You potentially have no club which can be sustainably promoted,” wrote Halliday. “How is this acceptable? It is the RFU who is expected to look after the whole game. Instead, you are alienating the very clubs ... for whom you are responsible.” The letter also claims that efforts by the Tier 2 Board to negotiate fair and reasonable criteria for ground capacity were circumvented by decisions taken at a Professional Game Board meeting that was allegedly not quorate. Halliday believes “the legality of what has taken place is clearly questionable” and says aspiring Championship clubs have been left in “an unacceptable position” by the RFU. “Your executive directors have failed in significant fashion to take care of this process,” he told Ilube. “Recent actions by the RFU legal team seem to have been [about] obfuscating and protecting the status quo which is clearly not consistent with [RFU] Council decisions. This threatens the game in our country given its seriousness. Further, the commitment by Bill Sweeney and the [RFU] executive to discuss in good faith the funding gap between the promoted club and the existing Premiership clubs has not been fulfilled despite numerous requests.” Sign up to The Breakdown The latest rugby union news and analysis, plus all the week's action reviewed after newsletter promotion The RFU is already under fire on several fronts, with significant year-end financial losses due to be reported imminently and the national team having lost seven of their past nine Tests. There are also fears the financial situation at Twickenham may frustrate a plan by the Rugby Players’ Association to extend much-needed welfare support to tier 2 players. In response the RFU stressed that a new Tier 2 Board with an independent chair was now in place. “It is through this board that all matters relating to rugby’s second tier are raised and managed,” said a spokesperson. “The board members are working collaboratively to deliver a reimagined tier 2 from next season.”

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The Kingdom of Saudi Arabia’s real estate developer ROSHN Group recently held the groundbreaking ceremony for ALMANAR, its inaugural fully integrated residential community in Makkah. The event was held under the patronage of advisor to the Custodian of the Two Holy Mosques and Governor of Makkah Region Prince Khalid Al-Faisal. During the event, attendees had the opportunity to explore the show villas and discover the diverse residential typologies available within the community, highlighting the Group’s mission to transform urban development and improve quality of life in the Kingdom. ALMANAR, a 21 million square meter community by ROSHN, features 33,000 residential units, a sustainable living environment, and green spaces, focusing on human needs. برعاية كريمة من صاحب السمو الملكي الأمير خالد الفيصل بن عبدالعزيز آل سعود، أمير منطقة #مكة_المكرمة ، وبحضور معالي أمين العاصمة المقدسة، أ. مساعد الداود، وسعادة الرئيس التنفيذي للهيئة الملكية لمدينة مكة المكرمة والمشاعر المقدسة، م. صالح الرشيد، وسعادة الرئيس التنفيذي للهيئة العامة... pic.twitter.com/lGWmwourJD It ensures effortless access to a wide array of community facilities and services, including schools, mosques, shopping centers, and healthcare facilities. With vibrant streets, open spaces, and recreational areas, ALMANAR fosters social connections, strengthens community bonds, and cultivates a deep sense of belonging. The community is strategically situated within the Al-Haram Boundaries, just 20 minutes from the Grand Mosque, less than an hour from King Abdulaziz Airport in Jeddah, and two minutes from Makkah Gate. It is distinctive in its location and design, blending traditional architecture with modern materials, resulting in a distinctive destination. “Spanning over 21 million square meters, ALMANAR will offer over 33,000 homes and provide over 150 amenities to cater to residents’ needs.” “ALMANAR Community represent a pivotal step creating an integrated living environment within Makkah Al-Mukarramah, which will be only 20 minutes away from Al-Masjid Al-Haram. As ROSHN Group, we are committed to both raising the quality of life and contribute to reshaping the urban landscape in Makkah Al-Mukarramah.” ROSHN Group’s Acting Group CEO Dr Khalid Johar said.Manmohan Singh Death LIVE: Former PM Passes Away At 92; Tributes Pour In

It’s gratifying when issues, particularly challenging ones, move beyond the talking stage into the action phase. Addressing the state’s housing shortage is one of those issues. The level of engagement regarding the lack of affordable housing, especially, demonstrates that towns in the Monadnock Region are taking the problem seriously. Three communities in the region, including Keene, recently received a Housing Champion designation from the state for efforts to address the housing crisis. Hinsdale, Jaffrey and Keene were among 18 communities in the state recognized by the N.H. Department of Business and Economic Affairs (BEA) for their efforts to support “affordable, accessible and sustainable” housing development. With a Housing Champion designation, communities become eligible to apply for grants. This good news comes at a time when suitable housing is out of reach for many. The median price for a single-family home in New Hampshire has topped $500,000 ($373,850 in Cheshire County), and the median monthly rent for a two-bedroom apartment including utilities has reached $1,833 ($1,455 in Cheshire County), according to the N.H. 2024 Residential Rental Cost Survey Report. The state Legislature created the Housing Champion Designation and Grant Program in 2023 and allocated $5 million to help municipalities create more housing. The BEA administers the designation process and related programming. Communities are invited to apply for the designation, which opens the door to funding for infrastructure and per-unit production. To qualify, communities must provide documentation demonstrating that zoning and land-use regulations promote workforce housing and that the community trains members of land-use boards regarding applicable procedures and laws. Communities must also show they are implementing sewer and water infrastructure improvements, as well as public transportation and walkability infrastructure such as sidewalks. Keene earned high marks for steps taken to address housing needs, including zoning updates, infrastructure investments and stakeholder training. Amendments to zoning and land-use regulations have been part of the city’s plan to encourage housing development, such as above-the-store apartments and so-called Cottage Courts for small-footprint housing. The city also has plans to embark on a major downtown infrastructure upgrade. Keene Planning Board members say they’ve seen a growing interest in the new Cottage Court designation, according to a recent report by The Sentinel’s Abigail Ham. Last week, the board approved an architectural plan to renovate a multifamily home on Roxbury Street under the Cottage Court designation. The three-story building will include four units — one more than zoning would normally allow. Earlier this month, The Sentinel’s Rick Green reported that former Keene Mayor George Hansel and businessman Jared Goodell are planning to build 17 small apartments in vacant office space on the second floor of the Silk Mill building, which they own as Emerald Development LLC. Noting a strong demand for smaller, affordable apartments, Goodell said he also has projects underway to add residential units along Marlboro Street. And in September, Keene Housing broke ground on a project at the old Roosevelt School on Washington Street that will add 30 rent-subsidized units to the city’s rental stock. These are just a few of the housing projects underway in the region. In Peterborough, Catholic Charities NH, along with community partners, broke ground in October on its Vose Farm Residences, a 96-unit mixed-income housing development. The first units are slated to be ready for occupancy in 2026. Avanru Development Group’s Swanzey West Apartments, an 84-unit complex along Route 10 completed this year, is already fully leased, according to the Monadnock Economic Development Corp. The town of Swanzey has approved well over 400 multifamily housing units since 2020, says Town Administrator Michael Branley. This may seem like a lot of development at once, but creating enough housing to meet the need is a tall order. The city of Keene alone needs about 1,400 new residential units to meet rising demand over the next decade, according to a Housing Needs Assessment published in 2023. A Saint Anselm College survey this year found that 75 percent of New Hampshire voters polled say their communities need more affordable housing, and 61 percent think that multifamily housing should be more widely available. Additionally, 59 percent say they want more affordable homes in their communities and neighborhoods. “We have to attack this housing problem from all angles,” Hansel said. And communities in the Monadnock Region are doing just that.