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jili games logo Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

Get a jump on your shopping (while these deals last). Black Friday might seem like the best day to get all your holiday shopping done early on the cheap, but this year, many brands have quietly launched early deals that are so good, we had to round them up for you here. From home products that will give your space a chic upgrade to beauty essentials and stylish jewelry pieces, there’s something for everyone on this list. These deals start at under $5 — but you’ll want to act fast, or else you might miss them. 50% off this deeply hydrating gel wash that “melts” into a cleansing oil Designed specifically for dry skin, this hydrating offers a luxe face-washing experience, despite the thrifty price tag. Formulated to nourish your complexion with ingredients like grapeseed oil and vitamins C, E, and B5, it has a gel-like consistency that quickly transforms into an oil as you massage it in. 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Is Tomorrow A Holiday Trends After Death Of Former PM Manmohan SinghWe're quickly approaching the new year, and that means fans are speculating about what the next 12 months holds for their favorite pro wrestlers. Wrestling is a year-round business, so there is no beginning and end of the season like there is in most professional sports, but we still view the new year as a fresh start in many ways, especially in WWE when WrestleMania season kicks in. Between AEW and WWE, there are over 200 wrestlers working at every level. There is only so much TV time to go around, so that means bookers have to make tough choices about who to feature in prominent roles. There are some people at the top who are practically guaranteed to be given heavy screen time like Jon Moxley and Roman Reigns, but the rest of the rosters have to fight for every opportunity. Let's take a look at 10 people AEW and WWE need to push in 2025. Brody King has been featured as a member of House of Black, but he has proved on several occasions that he can shine as a singles star, too. His matches with Darby Allin have been well-received by fans, but he has come up on the losing end more often than not in that feud. While there is still life left in the HOB stable, seeing King get a run with a singles title in 2025 would raise his stock significantly. He is a talented powerhouse who has displayed the ability to work with opponents of any size to produce fun and brutal encounters. There is no reason why he shouldn't be a top contender for the TNT or International Championship at some point. Gunther was always the main focus of Imperium, but over the past year, Ludwig Kaiser has proved he is a valuable asset. Mr. A+ Everything is a great heel who can get the crowd to boo him at the drop of a hat, but his real value lies in his in-ring ability. Kaiser is a versatile wrestler with the ability to work with just about anybody. He is big enough to give powerhouses like Sheamus a good fight, but he isn't so big that he makes everyone else look small by comparison. He has enough speed to keep up with the high-flyers and enough technical ability to ground anyone. He's the kind of talent who can be trusted to put on a great performance every night. Lee Moriarty's technical ability has earned him praise and acclaim from across the wrestling world, but he is more than just a good hand. Moriarty has shown a lot of charisma in recent months. Joining forces with Shane Taylor Promotions has allowed him to embrace his heel side a bit more and show some of his character. Unfortunately, ROH is seen by fewer people than all other AEW programming, so his run as the pure champion and character developments have flown under the radar. Moriarty should be featured on AEW television more in 2025, especially if the company wants to live up to its "Where the best wrestle" catchphrase. His Final Battle match against Nigel McGuinness was a clinic and proof that he has more than enough skill to hang with the best in AEW. The NXT system has been hit or miss when it comes to creating homegrown talent for WWE, but one man who seems destined for greatness is Oba Femi. His power and athleticism already set him apart from most of the roster, but it's his presence that really makes him stand out. Few people are as intimidating as he is and that makes him valuable. The former North American champion has that indefinable quality that makes someone an ideal candidate to be a world champion someday. It's impossible to describe, but you know it when you see it. Femi's WWE future is bright as long as he stays out of trouble and keeps himself healthy. The only one who can get in his own way is himself at this point. Athena is the longest-reigning champion in ROH history and has had one of the best title reigns in all of pro wrestling, but the majority of fans have only seen a fraction of it. Just about every ROH title has been defended on AEW TV and PPVs, but for some reason, Athena is almost never included in these events. She has been carrying the ROH brand on her back for the better part of two years while having banger matches and producing great feuds. The fact that only a small percentage of fans have gotten to see it feels like a crime. When her reign eventually ends, Tony Khan needs to move her to AEW programming immediately. Not only would she be a great rival for many women on the roster, but she deserves a chance in the spotlight after all of her hard work. When Chad Gable aligned himself with The Creed Brothers and Ivy Nile, a lot of us hoped it would be a great opportunity for all of them to finally be seen as the talented wrestlers they are. So far, that has not been the case. Gable and the Creeds have had some good matches here and there, but they have yet to be given a substantial push and a real storyline, and that is doubly true for Ivy Nile. She has the look, the physical ability and the skill to be a standout performer in the women's division. It makes WWE's lack of effort to push her confusing. She would have been a perfect choice to be the inaugural women's intercontinental champion, but WWE had her lose in the first round of the tournament. If she isn't given more to do in 2025, the only people to blame will be management because she has done everything WWE has asked of her, and she's done it well. AEW has a lot of women who are good in the ring, but it takes more than wrestling ability to be a top star. It takes personality, charisma and a willingness to do things other won't for the sake of entertaining the crowd. Harley Cameron has all of those qualities and more. She has only been wrestling for AEW since May but has already racked up 29 matches between AEW and ROH programming. Granted, she has lost most of them, but her growth in that time has been tremendous. Not only does she throw herself into every match without fear, but she has quickly become one of the most entertaining personalities in the company. She doesn't care if you are laughing at her or with her as long as she is making you laugh. She can sing, she can do ventriloquism, she can wrestle, and she can crack a joke. If AEW doesn't push her as a babyface at some point, it's going to be a huge mistake. When Shayna Baszler defeated Ronda Rousey in her last WWE match, it seemed like management was poised to give her the push she has deserved for so long. Boy, were we mistaken. The Queen of Spades should already be a multi-time women's champion at this point in her career, but for some mysterious reason, she has never been given that spotlight. She has one of the most legitimately intimidating personalities on the roster, and she has real skill to back it up. How she hasn't been positioned as a monster heel who bulldozes her opponents is a headscratcher. When the women's Intercontinental title was revealed, it seemed like a perfect opportunity for her, but WWE booked her to lose in the first round of the tournament. 2025 needs to be the year WWE finally commits to pushing her or it's never going to happen. Ricochet has been a great addition to the AEW roster, but the company needs to give him a substantial push in 2025 if it wants to get the most out of him. He's already proved countless times that he can steal the show against opponents of all sizes, but he's never been given a chance to really sink his teeth into the character side of the business. In WWE, Ricochet was rarely used to his full potential. He can be so much more than just a high-flyer, and AEW is in a position to let him prove it. He seems to be entering into some kind of storyline with The Hurt Syndicate. Whether it ends with him becoming a member of the group or its enemy is what remains to be seen. Even a run as the ROH world champion would give him the opportunity to show he can carry a brand. Let's just hopes he leaves some of his recent antics on social media in the past. Ever since Jacob Fatu arrived on the scene in WWE, fans have been interested in him. He has an aura that is completely unique, and that is something you can't underestimate in this business. Solo Sikoa had something similar when he was first called up to the main roster. He was the silent enforcer who struck fear into the hears of everyone, including his own Tribal Chief at times. Now, Fatu fills that role in the new Bloodline while Sikoa has grown into a vocal leader. The way WWE has booked him has helped add to his mystique. Fans went from not knowing much about him to wanting to see him challenge for championships in the span of a couple of months. At the very least, a run with the IC or U.S. title would allow WWE to test the waters. If he can have a successful midcard title reign, it wouldn't be surprising to see The Samoan Werewolf in the main event scene by 2026.

NoneMARINA — Joby Aviation recently announced it has entered the final phase of certification for its electric air taxi after conducting its first Federal Aviation Administration testing under Type Inspection Authorization. The company expects to start Type Inspection Authorization flight testing in 2025 with its first FAA-conforming aircraft currently being built in Marina. Related Articles Technology | Five facts about electric vehicles in 2024 Technology | Thinking of buying an EV? You might want to move quickly Technology | ‘Alarming’ new car prices push Bay Area buyers toward used vehicles, but they’re pricey, too Technology | Car insurance premiums are rising: Which Bay Area cities pay more? Technology | Walters: Major hurdles ahead for California’s zero-emission vehicle mandate Joby is developing electric air taxis, designed to carry a pilot and four passengers, for commercial passenger service. The air taxis can reach speeds up to 200 mph, offering high-speed mobility with a fraction of the noise produced by helicopters and zero operating emissions. The testing involved pilots from the Federal Aviation Administration evaluating human factors elements of flight safety using an FAA-conforming flight deck in a Joby simulator in Marina. Type Inspection Authorization testing is considered the final phase of the type certification process, which paves the way for an aircraft to begin commercial passenger operations, according to Joby. This phase involves FAA test pilots conducting testing to validate an aircraft’s performance and safety in accordance with previously approved certification test plans. “This milestone demonstrates Joby’s continued industry leadership and is a reflection of the maturity of our test program and the rigorous company testing we’ve already completed,” said Joby Aviation Founder and CEO JoeBen Bevirt in a press release. “As well as continuing the for-credit testing of components, aerostructures and systems that is already underway, we are targeting the start of Type Inspection Authorization flight testing in 2025 with our first FAA-conforming aircraft, which is currently being built at our facility in Marina, California.” Joby Aviation has been doing business in Marina for about the past seven years, where it launched production of its aircraft at its Pilot Production Plant with the first aircraft rolling off the line in June 2023. The Type Inspection Authorization tests were conducted according to a set of criteria outlined in an FAA-approved human factors certification test plan and measured pilot workload under various expected flight conditions, physical ergonomics of the flight deck, as well as other human factors aspects of aircraft safety. Four FAA test pilots completed three days of Type Inspection Authorization testing during the engagement. Earlier this month, Joby Aviation successfully completed static load testing of the tail structure, marking the first time the company has tested a major aerostructure of its aircraft for-credit with FAA representatives present, said the company. The tests took place in Santa Cruz as part of a rigorous testing campaign covering all of the structures, components and systems on the aircraft, producing data that is required for FAA type certification of the aircraft. During the static load tests, Joby engineers applied loads to the aircraft’s tail structure that far exceed the maximum forces the structure is expected to experience during flight. The FAA-conforming tail structure used in the test, along with the test procedure, instrumentation and applied loads, are outlined in Joby’s certification documents, which have been approved by the FAA as part of the certification process. Joby Aviation has offices and workshops and is headquartered in Santa Cruz, as well as facilities in San Carlos, Washington, D.C., and Munich, Germany. In September 2023, Joby chose Dayton, Ohio, as the site for its new manufacturing plant. Joby is also developing a world-class manufacturing facility in Marina, in addition to its integrated test lab and flight-testing capabilities, and where the first of its aircraft rolled off its Pilot Production Plant line in 2023. In April of this year, Joby broke ground on its new 220,000-square-foot manufacturing facility in Marina, expecting to begin operations in 2025. The second production prototype aircraft to roll off the company’s pilot production line was the backdrop for the ground-breaking ceremony. The company has said the expansion will more than double the total footprint Joby Aviation has at the Marina Airport and will enable the company to deliver 25 aircraft a year.

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