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bet365 poker LeSean McCoy reacts to Patrick Mahomes discussing the benefits of close games. The NFL scheduled a rare slate of Wednesday games this season to ensure it will have games played on Christmas Day, and Patrick Mahomes is not happy about it. The Kansas City Chiefs are one of four teams that will have to spend their Christmas at work with a matchup against the Pittsburgh Steelers. The Baltimore Ravens will play the Houston Texans later that night. That will also mean Mahomes and his teammates will play three games in 11 days. They play the Cleveland Browns Dec. 15 and the Houston Texans Dec. 21. Last year, the Chiefs faced the Las Vegas Raiders in a Christmas Day game, but that game was on a Monday. The Chiefs will have less time than usual to prepare for both the Texans and Steelers games. The Houston matchup will be played on a Saturday, and the Steelers game is on a Monday. CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM Kansas City Chiefs quarterback Patrick Mahomes (15) is pressured by Buffalo Bills linebacker Von Miller, left, during the first half Nov. 17, 2024, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes) Mahomes, who already had to give up his holiday for a football game, agonized over the idea of playing all those games in that short amount of time. "It’s not a good feeling," Mahomes told reporters Wednesday. "You never want to play this amount of games in this short of time. It’s not great for your body. But, at the end of the day, it’s your job, your profession. You have to come to work and do it." Mahomes was asked whether he has ever had three games in such a short span. "I haven’t in football," he replied. "All you can do is focus on the game. The practice you have that day," Mahomes added. "I try to prepare my body all year long for this stretch. That’s tailoring my workouts, tailoring how you practice and prepare. "And the coaches do a great job of taking care of us on the practice field. We practice as hard as anybody, but they know how to dial it back when needed." (L-R) Taylor Swift, Brittany Mahomes and Ashley Avignone react during the first half of an NFL football game between the New England Patriots and the Kansas City Chiefs Dec. 17, 2023, in Foxborough, Mass. (AP Photo/Michael Dwyer) On top of a strenuous workload, Mahomes and his family will not be able to spend Christmas at home this year for the second year in a row. Mahomes and wife Brittany are both Christians . "My Christian faith plays a role in everything that I do," he told reporters before the Super Bowl in February 2023. "I always ask God to lead me in the right direction and let me be who I am for His name. So, it has a role in everything that I do. Obviously, we’ll be on that huge stage in the Super Bowl that He’s given me, and I want to make sure I’m glorifying Him while I do it. "I feel like I’ve grown in my faith these last few years, and I think that’s given me more sense of who I am and why I play the game. It just kind of relieves the pressure of playing a football game because I know that I’m on that football field to glorify Him before everything. So, it’s not about winning or losing. It's about going out there and being the best that I can in His name." BRETT FAVRE BACKS PATRICK MAHOMES ON PRESIDENTIAL ENDORSEMENT STANCE AMID TRUMP VS. TAYLOR SWIFT CONTROVERSY Brittany Mahomes, wife of Kansas City Chiefs star quarterback Patrick Mahomes, says Super Bowl wins will never be the same after the shootings at the team's celebration rally Feb. 14, 2024, in Kansas City, Mo. (Tammy Ljungblad/The Kansas City Star/Tribune News Service via Getty Images) Brittany is pregnant with their third child. The NFL has played on Wednesday in the past. The most recent Wednesday game was played in 2020, when the Steelers and Ravens had their game pushed back because of a COVID-19 outbreak. In 2012, the NFL’s opener between the Giants and Cowboys was played on a Wednesday so the TV networks could broadcast Barack Obama’s speech at the Democratic National Convention. But before those games, the NFL had not had a Wednesday game since the Lions and Rams played Sept. 22, 1948. "It’s a unique situation. You just have to manage it," said Chiefs coach Andy Reid, whose team will have played on every day of the week but Tuesday this season. "It is what it is. You make the best of it." It’s not as if the games involved in the Christmas stretch are throwaways, either. Each has significant playoff ramifications. CLICK HERE TO GET THE FOX NEWS APP Kansas City Chiefs running back Kareem Hunt (29) is congratulated by quarterback Patrick Mahomes (15) after scoring a touchdown against the San Francisco 49ers during the second quarter at Levi's Stadium. (Kyle Terada/Imagn Images) The Chiefs have already clinched the AFC West, but they are trying to fend off Buffalo and Pittsburgh for the No. 1 seed and a first-round playoff bye. The Steelers are two games ahead of the Ravens in the AFC North heading into this weekend and could clinch a playoff berth if things fall their way. The Texans are two games up on the Colts in the AFC South. "The main thing is you get guys ready for the game. Give them a chance to get ready for the game," Reid said. "They’re going to do whatever you present to them. You try to help them out with that. Right now we have a normal week right here. We have to take care of business here." The Associated Press contributed to this report. Follow Fox News Digital’s sports coverage on X , and subscribe to the Fox News Sports Huddle newsletter . Jackson Thompson is a sports writer for Fox News Digital. He previously worked for ESPN and Business Insider. Jackson has covered the Super Bowl and NBA Finals, and has interviewed iconic figures Usain Bolt, Rob Gronkowski, Jerry Rice, Troy Aikman, Mike Trout, David Ortiz and Roger Clemens.

The Ridgefield school board Tuesday voted unanimously to place two three-year levies on the Feb. 11 special election ballot. The proposed replacement operations levy would collect a total of $44 million from 2026 to 2028, with an estimated tax rate of $1.75 per $1,000 of assessed property value. The proposed capital projects and technology levy would collect $21.2 million over the same period, with a focus on building a third elementary school and maintaining services. The projected capital levy rate would be 84 cents per $1,000 of assessed property value. The three-year levies require a simple majority to pass. If approved, they would go into effect in January 2026. Two community members spoke at the meeting in support of the levies. “As an educator, I’ve witnessed firsthand how investments in our schools strengthen the heart of our community,” said Kerri Upton, vice president of Citizens for Ridgefield Schools and special education lead at Union Ridge Elementary School. If both levies pass, the owner of a $500,000 house would pay an estimated $1,890 in annual property taxes in 2026. The cost includes the existing 2012 and 2017 existing bonds. This year, the property tax rate for Ridgefield schools was $2.53, which includes the current operations levy and existing bonds, and owners of a $500,000 home paid $1,265. In August 2022, voters approved the current 2023-2025 operations levy of $30.7 million, with an anticipated rate of $1.50 per $1,000 of assessed property value. And unexpected increase in Ridgefield’s property values meant taxpayers actually paid $1.43 in 2023 and $1.47 in 2024 per $1,000 of assessed property value. The operations levy “bridges the gap between state funding and the actual costs of funding our schools,” said Kelliana Cole, a Ridgefield parent and member of Citizens for Ridgefield Schools. “It funds teachers, classroom support, supplies, transportation and enrichment programs — all essential services that directly impact every student’s education and well-being.” In the past, operations levy money has gone toward sports and activities, special education, student supports, staff professional development, facilities and operating costs. About $15 million from the capital levy, $21 million in impact fees on new development and $16.5 million in state funding would go toward building the elementary school, if the capital levy is approved. “The capital and technology levy addresses the district’s most urgent needs, including the plans for a third elementary school to alleviate overcrowding,” Upton said. “This was developed through extensive community input.” The district also plans to allocate funds from the capital levy to student and staff technology replenishment cycles, according to a November school board meeting presentation. Bonds vs. levies In the past 35 years, Ridgefield passed only four out of 17 bonds, according to district data. Voters in April rejected the most recent bond proposals, which would have collected between $70 million and $190 million. Bonds are repaid with property taxes over as many as 40 years and must be approved by a 60 percent vote. With feedback from community members about the April bond, the school board landed on the two proposed levies. The board and a crowd of about 30 clapped after each levy placement was approved. “This is exactly what the community asked for: to use community input to inform your next ask and be smart about funding,” Cole said. “It leverages community voices and maximizes outside resources to address the need for a new elementary school.”While there are healthy debates to be had about biometrics, few would argue that tools like biometric face matching can make the airport experience smoother and faster. A new study commissioned by Amadeus and conducted by market research firm Mercury Analytics confirms what anyone who has ever set foot in an airport knows: travelers hate friction. The biometrics sector, as it happens, also loathes friction, and so the fit is clear: according to a release from , “it is clear that technology can have the biggest impact in overcoming the gaps that currently exist in the traveler experience.” Travelers gave the thumbs-up to planning apps, automatic rebooking for delays, digital bag tracking, integrated travel booking across airlines and hotels, and fully and travel documents – all cited as useful ways to relieve the stress of a journey. “Whether it is , mobile apps, digital traveler identification, disruption management, or other applications, we believe there are opportunities to deploy technology to further relieve distress,” says Rajiv Rajian, executive vice president and chief commercial officer, Americas, Travel, Amadeus. Tech, however, is best paired with a human component. Despite the convenience of biometric check-in and systems, travelers report wanting more human interaction during airport security and border control, as well as hotel and accommodation check-in and check-out. Amadeus’ Senior Vice President of Solution Consulting Robert Buckman says “technology can make a significant impact in overcoming travel friction and remains our unwavering mission. By innovating with our customers and partners – including airports, hoteliers, travel sellers, airlines, payments and corporations – and leveraging data orchestration across the trip lifecycle, together we can help breakdown silos across the .” One such innovation is on display at Princess Juliana International Airport (PJIAE) in St Maarten, where , an Amadeus company, has deployed its Seamless Border Program in the reconstructed arrivals area. A release says the program uses “real-time flow orchestration through advanced biometric technology to verify passenger identities quickly and accurately.” For eligible travelers, transaction times for passportless e-Gate crossings are reduced to 6-10 seconds per entry. “Delivering a contactless, stress-free experience is essential to setting new standards in the industry,” says Vision-Box Vice President of Strategic Sales & Global Partnerships, Jeff Lennon. “This marks a major achievement for Vision-Box and its long-lasting partners, fully demonstrating the power of .” A study from tells a similar tale to that of Amadeus. The Entrust Seamless Travel Experience Survey’s bane and kryptonite is friction. Customs, immigration, and visa applications are typically full of it, so it is little wonder the data shows 66 percent of travelers expressing preference for options such as biometric corridors (a path or location that uses biometric technology to process people without the need for manual processes) and remote . If options can reduce airport wait times by 20-30 percent, 92 percent of respondents indicate they would use them. likes biometrics best, with general support standing at 88 percent of travelers. Next are Canada and Spain, at 53 and 56 percent respectively. Those pesky data privacy concerns, however, are not completely gone: in the UK and U.S., there is more concern for potential technological failures and the ways in which data is managed and protected. That said, travelers have suggestions for how to optimize frictionless travel. Electronic visa applications, remote identity verification, and were tabled as ways to make border processes faster and more secure. “Travelers are calling for an experience where security meets convenience,” says Gordon Wilson, vice president of identity verification at Entrust. “With weather, engineering, and worker issues already causing regular disruption, technology needs to be set up to ensure that it alleviates the barriers to travel without creating new ones. To help meet this demand, Entrust aims to redefine through trusted digital identity.” The Seamless Travel Experience Survey was conducted for Entrust by market research firm Cint, involving 1,750 respondents across the United States, United Kingdom, Canada, Colombia, Spain, Australia and India. Indeed, it appears to be a losing battle for friction, as the combined effort to smooth it out of existence rises in strength and numbers. In a , Condatis, the UK market leaders in Entra Identity and Access Management solutions, ask you to imagine “a world where your travel experiences are tailored to your every preference, seamlessly and securely.” Condatis uses Entra Verified ID’s decentralized capabilities to develop decentralized ecosystem management tools in Cenda and partnering with the decentralized and (SSI) communities. “Our goal,” it says, “is to reimagine the traveler experience by giving travelers the ability to carry their own data, profiles, and preferences as credentials in . These credentials, which can include verifiable, self-attested, or biometric data, break today’s siloed mobile data models by making verifiable, reusable, and data-rich attributes available to entire ecosystems.” These ecosystems can connect processes like and flight check-in with “verifiable data (passport), personal preferences (food or room preferences), and biometrics (for virtual or physical access control).” These could in turn be analyzed by so-called , which “involves the development of agents that work with us in a transparent and consenting manner to solve complex tasks,” to curate “hyper-personalized offers, itineraries, and experiences based on our preferences.” While the tendency may be to imagine yet another vector for endless ads, the post brings up an interesting example: a customer who is running late and misses their flight. “Rather than using multiple mobile applications and search engine queries to cancel and reorganize bookings, find new flights, and book a hotel, your Agentic AI agents handle this on your behalf.” Suggestions and recommendations are offered based on your location, flight, and hotel preferences, as well as profiles and preferences stored in your digital wallet. Ai airports across the globe, friction loses ground by the day. has plans to implement its friction-reducing E-GATE system at Kotoka International Airport by the end of 2024. According to from 3 News, Flagbearer of the NPP Dr. Mahamudu Bawumia confirms that those who have a Ghana card will only need to slot the card in at immigration to gain clearance. | | | | | | | | | |

Australian soldier Oscar Jenkins has been captured by Russia. What happens now?https://arab.news/jay4f DUBAI: Palestinian Chilean singer Elyanna recently lit up New York’s Times Square when she was featured on a Spotify Arabia billboard, highlighting the streaming platform’s “Equal” playlist. Under the name “Equal Arabia,” the local version of Spotify’s Global Music Program aims to amplify the work of women creators by using the platform’s resources and generating more opportunities for these creators through delivering a global, cohesive and branded experience. A post shared by Spotify (@spotifyarabia) A post shared by Elyanna (@elyanna) Each month, Equal Arabia spotlights an ambassador of the month, focusing on their new music release and encouraging fans to discover them, and Elyanna was picked as the latest feature, promoting her new track “Janni.” Elyanna has enjoyed a record year, sharing the stage with British band Coldplay on NBC’s “Today” show in New York in October, performing their song “We Pray.” A post shared by Elyanna (@elyanna) The track is part of Coldplay’s new album, “Moon Music,” which was released that month. Joining Elyanna and the British band on stage was Argentine singer and actress Tini, who is also featured on the song. Elyanna also released her own Arabic-language version of the track on Sept. 20. A post shared by Elyanna (@elyanna) Elyanna made her “Saturday Night Live” debut the same month, teaming up with frequent collaborators Coldplay on stage to perform the song. The singer took to Instagram to celebrate the milestone after the show by reposting footage of backstage rehearsals recorded minutes before she hit the stage. The “SNL” performance came just days after the 22-year-old appeared at iHeartRadio Music Festival in Las Vegas to perform the same song. Elyanna is expected to perform live with Coldplay again when the band heads to Abu Dhabi for four shows in the UAE capital in January 2025. The band will perform as part of the “Music of the Spheres World Tour” on Jan. 9, 11, 12 and 14 at Zayed Sports City Stadium. In August, she was on stage in Dublin to perform “We Pray” in Arabic. She performed alongside rapper Little Simz, Nigerian singer Burna Boy and Tini. “I’m still in awe of last night! Sharing this moment with all these amazing artists on @coldplay’s stage felt so wholesome,” she told her 1.7 million followers on Instagram. “I sang ‘We Pray’ in Arabic, I sang for hope and, most importantly, for my hometown Palestine.” The Los Angeles-based singer’s music is a mix of Arab and Western influences, which she attributes to her multicultural upbringing.

Shane Bieber says bonds led to re-signing with Guardians after he missed '24 following elbow surgery

OTTAWA — NDP Leader Jagmeet Singh said he won't play Conservative Leader Pierre Poilievre's games by voting to bring down the government on an upcoming non-confidence motion. The Conservatives plan to introduce a motion that quotes Singh's own criticism of the Liberals, and asks the House of Commons to declare that it agrees with Singh and has no confidence in the government. The motion is expected to be introduced on Thursday and the debate and vote are set for Monday. Singh said he is not going to trigger an election when he believes Poilievre would cut programs the NDP fought for. "I'm not going to be playing Pierre Poilievre's games. I have no interest in that. We're frankly not going to allow him to cut the things that people need. I want to actually have dental care expanded, I want people to actually start to benefit from the pharmacare legislation we passed," Singh said. With the NDP's expected support, the Liberals should survive this next confidence vote brought forward by the Conservatives. The Tories have vowed to bring forward non-confidence motions every chance they get. The party will have two more opposition motions after this one, which are expected to continue to call for non-confidence. The NDP are scheduled to have their opposition day on Friday. Earlier on Tuesday, Singh did acknowledge that the Conservatives have a sizeable lead on the NDP in public opinion polls, while giving a campaign-style speech to visiting party staffers from across the country. Most pollsters in Canada have recorded a roughly 20 point lead for the Conservatives over both the Liberals and NDP for the last few months. The non-confidence vote was scheduled after Speaker Greg Fergus intervened to pause a filibuster on a privilege debate about a green technology fund. The Conservatives have said they would only end that debate if the NDP agree to topple the government or if the Liberals turn over unredacted documents at the centre of the parliamentary gridlock. This report by The Canadian Press was first published Dec. 3, 2024. David Baxter, The Canadian PressMONROE TOWNSHIP, N.J., Dec. 02, 2024 (GLOBE NEWSWIRE) -- Ocean Power Technologies, Inc. ("OPT" or "the Company") (NYSE American: OPTT), today announced preliminary financial results for the second quarter ended October 31, 2024 (Q2FY25). The preliminary results included in this press release are subject to change and have not been audited or reviewed by our independent auditor. The Company expects to file its second quarter financial results and update in mid‐December. Preliminary Q2FY25 Financial Highlights (All figures are preliminary, unaudited, and subject to finalization): Revenue : Estimated to be greater than $2 million, compared to $0.9 million for the same period last year, representing a more than 2x increase. Net Loss : Anticipated net loss of approximately $4 million, compared to $7.2 million in the prior year period and representing a year-over-year decrease in net loss of more than 40%. Operating expenses have been reduced by approximately 40%, including reduced external expenditures leading to a material reduction in third party spend. Cash Used in Operating Activities : Estimated to be less than $4.7 million, compared to $7.5 million in the prior-year period and representing a year-over-year decrease of approximately 40%. Business and Operational Highlights During Q2FY25, the Company completed the second set of exercises of the previously announced follow-on contract as a subcontractor to EpiSci and successfully deployed several WAM-V autonomous surface vehicles during the Mission Autonomy Proving Grounds (MAPG) as part of Project Overmatch. Project Overmatch is a United States Navy initiative aimed at achieving a seamless and highly integrated warfighting capability by leveraging advanced data networks, artificial intelligence (AI), and machine learning. Under this contract, OPT continues to ruggedize and enhance the operational capability of its autonomous maritime technologies to support the U.S. military and its allies. The first set of exercises was concluded over the summer and the completion of these most recent exercises contributed to the revenue recognition noted above. The Company delivered several vehicles to customers in Latin America for commercial survey services. The Company signed its first service contract for multi-year support services for vehicles. Since the end of the quarter, OPT has received the final permits to install the previously announced PowerBuoy equipped with AT&Ts 5G equipment in Monterey Bay. The Company reaffirms its previously issued guidance that it believes it will reach profitability (excluding unanticipated extraordinary expenses) during the fourth quarter of calendar 2025. Performance to date reflects strong demand for products, effective cost management, and progress in strategic initiatives. Recent achievements, including recently announced partnerships and operational milestones regarding successful exercises and continued customer deliveries, further support the Company’s trajectory toward achieving this stated objective. Philipp Stratmann, OPT’s CEO and President, stated “We believe our preliminary results underscore the success of our strategic initiatives, such as focusing on national security and critical infrastructure solutions, coupled with targeted international expansion and our ability to execute for our customers. We have seen a recent uptick in demand for our services domestically and overseas and will continue to convert our pipeline to bookings and ultimately to revenue through future deliveries and additional opportunities to deploy our assets, and we remain committed to delivering long-term value for our shareholders. The success of our most recent quarter leads us to reconfirm our pathway to profitability in late calendar 2025.” CONFERENCE CALL AND WEBCAST INFORMATION A conference call to discuss OPT’s financial results will be held on Tuesday, December 17, 2024 at 9:00 AM EDT. Philipp Stratmann, CEO, and Bob Powers, CFO will host the call. The dial-in numbers for the conference call are 877-407-8291 or 201-689-8345. Live webcast: Webcast | Ocean Power Technologies FY2025 Q2 Earnings Conference Call (choruscall.com) Call Replay: Call replay will be available by telephone approximately two hours after the call's completion. You may access the replay by dialing 877-660-6853 from the U.S. or 201-612-7415 for international callers and using the Conference ID 13748550. Webcast Replay: The archived webcast will be on the OPT investor relations section of its website. INDIVIDUAL MEETING INFORMATION In an effort to increase relations with institutional investors, OPT management has dedicated time to hosting individual meetings with portfolio managers and analysts. If you are interested in scheduling a meeting with OPT management, please contact: Email: InvestorRelations@oceanpowertech.com , or Call: 609-730-0400 x401 ABOUT OCEAN POWER TECHNOLOGIES OPT provides intelligent maritime solutions and services that enable safer, cleaner, and more productive ocean operations for the defense and security, oil and gas, science and research, and offshore wind markets, including Merrows, which provides AI capable seamless integration of Maritime Domain Awareness Systems across platforms. Our PowerBuoy® platforms provide clean and reliable electric power and real-time data communications for remote maritime and subsea applications. We also provide WAM-V® autonomous surface vessels (ASVs) and marine robotics services. The Company’s headquarters is in Monroe Township, New Jersey, with an additional office in Richmond, California. To learn more, visit www.OceanPowerTechnologies.com . FORWARD-LOOKING STATEMENTS This release may contain forward-looking statements that are within the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are identified by certain words or phrases such as "may", "will", "aim", "will likely result", "believe", "expect", "will continue", "anticipate", "estimate", "intend", "plan", "contemplate", "seek to", "future", "objective", "goal", "project", "should", "will pursue" and similar expressions or variations of such expressions. These forward-looking statements reflect the Company's current expectations about its future plans and performance. These forward-looking statements rely on a number of assumptions and estimates that could be inaccurate and subject to risks and uncertainties. Actual results could vary materially from those anticipated or expressed in any forward-looking statement made by the Company. Please refer to the Company's most recent Forms 10-Q and 10-K and subsequent filings with the U.S. Securities and Exchange Commission for further discussion of these risks and uncertainties. The Company disclaims any obligation or intent to update the forward-looking statements in order to reflect events or circumstances after the date of this release or to provide further interim updates in the future.

The most startup-friendly countries in 2024RADNOR, Pa., Dec. 02, 2024 (GLOBE NEWSWIRE) -- Certara, Inc. (Nasdaq: CERT), a global leader in model-informed drug development, today showcases its impact on research by celebrating more than 100 publications secured in 2024 as well as the 12 Certara scientists included on the 2024 Stanford/Elsevier list, which highlights the top 2% of the most cited scientists across the globe. Stanford/Elsevier's Top 2% Scientist Ranking Now in its 7 th iteration, the Stanford/Elsevier's Top 2% Scientist Ranking list includes the top and most-cited researchers globally in 22 scientific disciplines and 174 sub-disciplines and encompasses standardized data on citations, h-index, and a wide range of bibliometric indicators. The following Certara researchers appeared on Elsevier’s top 2% of the world’s most-cited researchers list in 2024, highlighting recent and career-long impacts. Amin Rostami-Hodjegan, Chief Scientific Officer at Simcyp Frederic Bois, Senior Scientific Advisor & Head of Mechanistic Modelling Hannah Jones, Senior Vice President, Head of Simcyp PBPK Modelling Services Hugo Geerts, Head of QSP Neurosciences Khaled Abduljalil, Senior Principal Scientist at Simcyp Karen Rowland-Yeo, Senior Vice President, Client & Regulatory Strategy Masoud Jamei, Senior Vice President of Research and Development at Simcyp Piet H van der Graaf, Senior Vice President and Head of Quantitative Systems Pharmacology Patrick Smith, President of Certara Drug Development Solutions Rajesh Krishna, Distinguished Scientist, Drug Development Science Stephen Duffull, Senior Scientific Advisor Trevor Johnson, Principal Scientist at Simcyp "Certara is a science-driven organization, and our scientists are world leaders in their fields. Our clients rely on us to deliver advanced biosimulation software and the expert advice needed to interpret results for optimal strategic decision-making,” said William Feehery, CEO, Certara. 2024 Publications Certara scientists and publications span the entire drug discovery and development process from early discovery through clinical, regulatory, and post-approval. Key highlights and trends evident in 2024 publications are grouped into two primary categories below. Value and Impact of Biosimulation Strategies and Execution in Drug Development Pediatric oncology drug development and dosage optimization Mechanistic modeling’s impact on first-in-human dose predictions and clinical validations thereof Exposure-Response Analyses to Inform Dosing Considerations and Labeling Impact of physiologically-based pharmacokinetics (PBPK) modeling on Global Health The role of pharmacometrics in understanding Variability in Clinical Trials Extended Model-Informed Drug Development: Beyond Clinical Trials and Regulatory Approval Best practices for implementing technologies that streamline drug submission and approval processes Diversity in Clinical Trial Enrollment and meeting requirements of the FDA Diversity Action Plan Using real-world data to inform clinical patient management and treatment guidelines for COVID-19 Unlocking the Synergies of Generative AI in Regulatory Writing Preventing chaos: The Critical Role of the Submission Lead To learn more about Certara’s publications, please visit: www.certara.com/resources/publication About Certara Certara accelerates medicines using biosimulation software, technology, and services to transform traditional drug discovery and development. Its clients include more than 2,400 biopharmaceutical companies, academic institutions, and regulatory agencies across 66 countries. Learn more at certara.com. Certara Contact: Sheila Rocchio sheila.rocchio@certara.com Media Contact: Alyssa Horowitz certara@pancomm.com

Republic Services Inc. stock underperforms Monday when compared to competitorsCORAL GABLES, Fla. (AP) — RJ Johnson scored 23 points, including the go-ahead 3-pointer in the final minute, Daylen Berry added two clutch free throws and Charleston Southern surprised Miami 83-79 on Saturday. The Buccaneers led for the last four minutes of the first half and deep into the second half before a 3-pointer from Austin Swartz gave Miami a 76-75 lead with 3 minutes left in the game. A three-point play by Lynn Kidd gave the Hurricanes a 79-75 lead with 2:11 remaining. Berry hit a 3-pointer to make it 79-78 and Johnson followed with a 3 that gave the Buccaneers an 81-79 lead. Kidd missed in the paint for Miami but came up with a steal a few seconds later. With 15 seconds left, Swartz missed a 3-pointer and the Buccaneers rebounded. Miami put Berry on the line and he made both free throws for a four-point lead with 11 seconds remaining. Miami's Jalen Blackmon missed a 3-pointer with 8 seconds left, the Hurricanes' A.J. Staton-McCray grabbed the rebound and he missed a 3 as time ran out. Taje Kelly had 20 points, 11 rebounds and six assists for the Buccaneers (2-7), who snapped a five-game losing streak and defeated a Division I opponent for the first-time this season. Thompson Camara made five 3-pointers and scored 21. Brandon Johnson made six 3-pointers and scored 23 for Miami (3-4). Swartz scored 15 points off the bench and Staton-McCray had 13 points. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college basketball: https://apnews.com/hub/ap-top-25-college-basketball-poll and https://apnews.com/hub/college-basketball

Article content Amber Heard is weighing in on Blake Lively’s sexual harassment complaint against Justin Baldoni. Last week, Lively, 37, accused her It Ends With Us director and co-star Baldoni, 40, of harassment during the making the movie, which adapted Colleen Hoover’s bestselling 2016 novel and explores themes of domestic violence and emotional abuse. In the complaint, which was obtained by the Associated Press and the New York Times , Lively alleged that Baldoni and his production company embarked on a “multi-tiered plan” to damage her reputation after a meeting in which she and her husband Ryan Reynolds addressed “repeated sexual harassment and other disturbing behaviour” during the making of the film. Baldoni has denied the claims and hired the same crisis manager Heard’s ex-husband, Johnny Depp, did during the former couple’s highly publicized 2022 defamation lawsuit, which he won. But Heard said Baldoni’s hiring of Depp’s former PR representative Melissa Nathan of The Agency Group reminds her of her own legal battle against her ex that played out in a Virginia courtroom more than two years ago. In an exclusive statement shared with NBC News , Heard, who moved to Spain following the trial, said: “Social media is the absolute personification of the classic saying ‘A lie travels halfway around the world before truth can get its boots on.’ I saw this firsthand and up close. It’s as horrifying as it is destructive.” According to the Washington Post , Lively’s complaint alleges that Baldoni “flouted intimacy protocols on set, improvising kisses in scenes without an intimacy coordinator present and trying to add sexual or nude scenes she found unnecessary.” When they weren’t shooting, the complaint goes on to add that Baldoni “made sexual comments objectifying her and other actresses on set, and entered her trailer while she was undressed.” The complaint goes on to accuse Baldoni of orchestrating a campaign to discredit her during the film’s rocky promotional tour this past summer, which included trying to drum up headlines to push the narrative that Lively had a “less than favourable reputation.” Anticipating that Lively might go public with her complaints when the film was in theatres, Baldoni’s personal publicist allegedly texted Nathan to ask that she ramp up an online campaign to discredit Lively. “I think you guys need to be tough and show the strength of what you guys can do in these scenarios,” the Post quotes his publicist as texting to Nathan. “He wants to feel like she can be buried.” According to the Post , Lively accuses Nathan’s production company, Wayfarer Studios, of working with a subcontractor and his “digital army” to help “create and sustain a negative news cycle and social media algorithm” about her. “The Baldoni-Wayfarer team would then feed pieces of this manufactured content to unwitting reporters, making content go viral in order to influence public opinion and thereby cause an organic pile-on,” Lively’s complaint alleges. “The effects on Ms. Lively’s professional life were immediate and substantial,” the complaint reads. “Given the ongoing nature of the campaign and the associated negative public sentiment, Ms. Lively did not believe she could proceed with public appearances or events without being forced to openly discuss what happened on set.” While Lively plugged the film as a romantic drama, the complaint says Baldoni “used domestic violence ‘survivor content’ to protect his public image.” The press tour for the film, which was a summertime box office hit, was plagued by rumours of infighting between Baldoni and the rest of the cast. At various red carpet events promoting its release, Baldoni and Lively weren’t photographed together. On the red carpet with E! News , Lively said that Reynolds was very involved in It Ends With Us , and adapted a pivotal moment in the film. “The iconic rooftop scene in this movie, my husband wrote it. Nobody knows that,” she said. The film’s credited screenwriter, Christy Hall, told PEOPLE that she thought the actors were improvising. Additionally, according to The Hollywood Reporter , Lively sought to have her own edit of the movie, which was overseen by Shane Reid, who also worked on her Reynolds’ Deadpool & Wolverine . But Lively’s promotion of the movie hit a sour note with some moviegoers after she appeared on the official It Ends With Us TikTok page, touting the film in a lighthearted manner. “Grab your friends, wear your florals and head out to see it,” she said. Norwegian journalist Kjersti Flaa fanned more backlash when she reshared an old interview with Lively that went viral, which she titled: “ The Blake Lively interview that made me want to quit my job. ” Flaa called Lively’s “dismissive” demeanor during their 2016 sit-down was “the most uncomfortable interview situation I have ever experienced.” “There are conspiracy theories out there accusing me of being paid by his PR team to help with their smear campaign. None of this is true,” Flaa said in an Instagram post . Meanwhile, Baldoni – who has been dropped by his talent agency, WME in the wake of the claims – promoted the project by highlighting his commitment to raising awareness about domestic violence. “If a Lily Bloom in real life can sit in this theater, and make a different choice for herself than the one that was made for her, maybe she sees herself on that screen and chooses something different for herself,” Baldoni said in a red carpet interview with Entertainment Tonight. On Monday, Baldoni’s lawyer Bryan Freedman addressed Lively’s claims that his client’s publicity team wrecked havoc with her career and damaged her reputation. “TAG PR operated as any other crisis management firm would when hired by a client experiencing threats by two extremely powerful people with unlimited resources,” Freedman told PEOPLE . Freedman went on to add that audiences ended up concluding that “Lively’s own actions, interviews and marketing during the promotional tour (were) distasteful, and responded organically to that.” But Lively has been supported by Hoover, who took to her Instagram Story praise the actress as “nothing but honest, kind, supportive and patient since the day we met.” Lively’s A Simple Favor director Paul Feig has also publicly backed her. “I’ve now made two movies with Blake and all I can say is she’s one of the most professional, creative, collaborative, talented and kind people I’ve ever worked with,” Feig shared on X. Sony Pictures, which released It Ends With Us , has also sided with Lively. “We have previously expressed our support for Blake in connection with her work on and for the film. We fully and firmly reiterate that support today,” they said in a statement to Variety . mdaniell@postmedia.comRwanda must address skills gap in financial sector – report

EAGAN, Minn. (AP) — Justin Jefferson might be weary of all the safeties shadowing his every route, determined not to let the Minnesota Vikings go deep, but he's hardly angry. The double and triple coverage he continually faces, after all, is a sign of immense respect for his game-breaking ability. The strategy also simply makes sense. “I would do the same," Jefferson said. "It’s either let everybody else go off or let Justin go off. I’m going to let everybody else go off. That would be my game plan.” When the Vikings visit Chicago on Sunday, they're expecting the usual heavy dose of split-safety coverage designed to put a lid on the passing attack and force them to operate primarily underneath. “We see that every week: Teams just have different tendencies on film, and then when we go out on the field they play us totally different,” Jefferson said, later adding: “I don’t really feel like anyone else is getting played how I’m getting played.” Jefferson nonetheless is second in the NFL in receiving yards (912) behind Cincinnati's Ja'Marr Chase, his former college teammate at LSU. Last week, Jefferson set yet another all-time record by passing Torry Holt for the most receiving yards over the first five seasons of a career. Holt logged 80 regular-season games and accumulated 6,784 yards for St. Louis. Jefferson has 6,811 yards — in just 70 games. “I want to go up against those single coverages. I want to go have my opportunities to catch a deep pass downfield, just one-on-one coverage, like a lot of these other receivers get," Jefferson said. "It’s definitely difficult going up against an extra person or an extra two people, but it is what it is and the concepts that we’re drawing up and the ways that we’re trying to get me open, it definitely helps.” With fellow tight end Josh Oliver ruled out of the game on Sunday because of a sprained ankle, T.J. Hockenson is certain to have his heaviest workload since returning from knee surgery four weeks ago. He's also certain that Jefferson will continue to see persistent double-teams. “It puts it on us to make some plays and do some things to get them out of that,” Hockenson said. Vikings coach Kevin O'Connell has been forced to dig deeper into the vault of play designs and game plans to help keep quarterback Sam Darnold and the offense on track. O'Connell said after Minnesota's 12-7 win at Jacksonville, when Darnold threw three interceptions to precipitate a safer strategy down the stretch, that he superseded his play-calling role with the wisdom of a head coach to help win that game. "Not just the egomaniac of wanting to score points and constantly show everybody how smart we are. There was a mode that I think you have to go into sometimes to ensure a victory,” O'Connell said on his weekly show on KFAN radio. Taking what the defense gives is usually the shrewdest strategy. “You’ve got to really implement some new things and some things that maybe you didn’t come across during your early coaching years whether as a coordinator or position coach or even when you’re responsible for a small area of the game plan as a younger coach," O'Connell said. "You really have to kind of look outside the lens of always what you see on tape.” AP NFL: https://apnews.com/hub/NFL

NASHVILLE — The Supreme Court on Wednesday will consider for the first time whether states can ban certain gender transition medical treatments for young people – a closely watched case brought by three transgender teens, their parents and a doctor, all seeking to ensure health care access they say is critical. At issue is a Tennessee law barring transgender minors from using puberty blockers and hormones, treatments the state characterizes as risky and unproven. Lawmakers said the state should instead encourage adolescents to “appreciate their sex, particularly as they undergo puberty.” The court’s ruling might have implications for the more than 100,000 transgender adolescents living in Tennessee or one of the 23 other states that has banned using the drugs to treat minors with gender dysphoria. The question of whether and how to medically treat young people whose gender identity is different than their sex assigned at birth has become a polarizing issue, one President-elect Donald Trump seized on in advertisements targeting transgender people during his campaign. The Supreme Court in 2020 extended employment protections to lesbian, gay, bisexual and transgender workers, but it has yet to rule on the constitutionality of lower court decisions involving bathroom access, athletes and medical treatment for transgender minors like 16-year-old L.W., one of the Tennessee teens behind the case at the high court. Her parents, Brian and Samantha Williams, now drive her five hours to receive care in North Carolina. The teen started gender care treatments when she was 12 and said they have allowed her to “get to be myself a little bit more.” “It took a huge stressor off my back,” L.W. said in an interview. “I have more friends now because I’m more confident, and I’m more able to socialize.” The Biden administration and the American Civil Liberties Union are representing the parents and teens, who are referred to in court filings by their initials or a pseudonym to protect their identity. The families say the Tennessee law amounts to unconstitutional sex discrimination and a broad restriction on treatments that nearly every major medical association says are appropriate and effective for minors. ACLU attorney Chase Strangio, who is arguing on behalf of the families, will be the first openly transgender lawyer to present a case before the Supreme Court. Tennessee’s Republican attorney general Jonathan Skrmetti says in court filings that states have long had the power to regulate medicine and that there is nothing unconstitutional about restricting the use of a drug for certain purposes, even when it can be used for treating other conditions, or imposing age limits for health treatments when the risks and rewards are too uncertain. One potential wild card in the resolution of the case is the incoming Trump administration and the possibility that the next solicitor general will flip the federal government’s position to align with Tennessee’s view. If that were to happen, the court could allow the ACLU to continue challenging the law on its own, which would keep the justices on track to issue a ruling by the end of June. Trump transition officials did not immediately respond to questions about the case before the court, but his team has said Trump intends to fulfill his campaign promises, which included a crackdown on gender transition care for minors. PATIENTS AND LAWMAKERS CLASH L.W. said she began to suspect she was trans in 2019, when she was 11. She’d long felt as if she were “drowning,” but she didn’t understand why. She wore baggy clothes to obscure her body, and she panicked the first time she saw a few facial hairs above her lip. She was so uncomfortable in boys bathrooms, she avoided ever using one at school. Eventually, she developed urinary tract infections. After a cousin came out as trans, L.W. began researching on YouTube and Google. But she was scared, so she didn’t tell her parents she thought she was trans until just after Thanksgiving in 2020, more than a year after she’d first put a name to her feelings. Brian and Samantha Williams both had gay friends, and they told L.W. they supported her, but neither felt comfortable immediately taking her to a doctor. L.W. was 12, and Brian worried the distress she felt might be normal puberty angst. “It’s not like we took this thing lightly and just did it,” Brian said. The family went to a progressive church, and the church had a therapist on staff who specialized in trans youth, so Samantha and Brian signed L.W. up for counseling. After roughly six months, the therapist diagnosed L.W. with gender dysphoria and recommended a team of doctors at Vanderbilt Children’s Hospital. At Vanderbilt, L.W. underwent tests, then, in the summer of 2021, her doctors prescribed the drug Lupron to stop her body from going through male puberty. The medication, which has been used for at least 30 years on patients who start puberty too early, is largely reversible, but it can affect a young person’s bone density if taken long term without hormone therapy. The teen said she felt instantly relieved. To her, the benefits “strongly outweighed” any side effects. At the time, no state had banned trans adolescents from receiving the kind of care Vanderbilt’s team offered. Doctors nationwide had been treating a few thousand young people a year with hormones and puberty blockers, according to data compiled for Reuters – a tiny fraction of America’s adolescent population. They faced little pushback. Multiple peer-reviewed studies have found that a majority of trans adolescents experience “satisfaction,” “confidence” and “improvements in psychosocial functioning” after such treatment. Almost as soon as L.W. left her first appointment, she asked to start estrogen, but her doctors and her parents decided to wait. L.W. went in for regular evaluations, and in September 2022, more than a year after she started Lupron, her doctors agreed to prescribe estrogen. Hormone therapy made life feel possible in ways it never had before, L.W. said. She started hugging her family. She recorded music and built Lego models. She and her younger brother staged Airsoft matches with other teenagers. Neighbors even told Samantha that L.W. talked to them for the first time. L.W.’s journey felt personal to her, a singular distress followed by her own unique wins. But her time at Vanderbilt coincided with a historic rise in gender dysphoria diagnoses. In 2021, about 42,000 young people nationwide received a diagnosis of gender dysphoria, nearly triple the number in 2017, according to data the technology company Komodo Health Inc. compiled for Reuters. The vast majority were not prescribed hormones or puberty blockers, the data shows. Still, as the numbers rose, lawmakers and activists across the country began to raise questions about gender clinics and the treatments doctors were offering. The same month L.W. started estrogen, the conservative podcast host Matt Walsh accused Vanderbilt of castrating, sterilizing and mutilating children for profit. Tennessee Gov. Bill Lee (R) promised to investigate the hospital. That fall, Walsh and a group of Republican state legislators held a “Rally to End Child Mutilation” in downtown Nashville. Only Arkansas and Alabama had passed bans on transition-related care at that point. But lawmakers in other conservative states signaled that they intended to prioritize similar restrictions. In March 2023, Tennessee adopted the legislation now before the Supreme Court. The law, known as SB 1, prohibits health-care providers from prescribing any puberty blocker or hormone for the purpose of enabling a minor to identify or live as “a purported identity inconsistent with the minor’s sex.” Providers who violate the law can be fined $25,000 for each prohibited treatment and are subject to disciplinary measures and potential civil liability in private lawsuits. Throughout the hearings on the legislation, Republican lawmakers treated gender dysphoria as if it were an illusion. A co-sponsor of the House bill described transitioning as a “fiction” and “fantasy.” Another representative said, “If you don’t know what you are, a boy or girl, male or female, just go in the bathroom and take your clothes off and look in the mirror and you’ll find out.” The Williams family watched the hearings, and Brian was infuriated. The lawmakers didn’t know his daughter. He and Samantha had taken L.W. to experts. They’d had what felt like a million hard conversations, and they’d followed the best evidence available. “All of a sudden to have a state come down and say that that’s not the right thing to do, that’s it’s abusive, that it’s wrongheaded, it’s just infuriating because I feel like I’m doing all the right stuff,” Brian said. EXPERIMENTATION OR DISCRIMINATION? After the bill became law, everyone in the Williams family agreed that discontinuing care wasn’t an option. L.W. was happy in ways she’d never been before she transitioned. If she stopped taking puberty blockers and estrogen, her body would begin to go through male puberty. She told her parents that was too painful to contemplate, let alone experience. Moving didn’t feel possible either. L.W.’s brother sobbed every time he thought about leaving his friends, and Brian’s elderly parents live in Nashville and rely on his help. That spring, Samantha saw an ACLU form that invited families to describe how they’d been affected by the legislation. She didn’t imagine, as she filled out the form, that she was signing up for a lawsuit that would eventually make its way to the Supreme Court. She only knew that she wanted to protect her daughter and she didn’t want to feel helpless anymore. Tennessee gave families four months to wean kids like L.W. off the medications, but in June, before the ban even took effect, Vanderbilt shut down its clinic. In June 2023, a District Court judge temporarily blocked the law, saying it discriminates based on sex and treats some teens differently because they are transgender. The judge said the benefits of the treatments are well-established and noted that Tennessee’s law bans the medications for a small subset of minors while making them available for adolescents who use them for other health issues. “If Tennessee wishes to regulate access to certain medical procedures,” wrote U.S. District Judge Eli Richardson, a Trump nominee, “it must do so in a manner that does not infringe on the rights conferred by the United States Constitution, which is of course supreme to all other laws of the land.” A divided panel of the U.S. Court of Appeals for the 6th Circuit soon reversed Richardson’s decision, rejecting the families’ claims of discrimination and allowing the state to enforce the law while litigation continues. Chief Judge Jeffrey Sutton said the law regulates gender transition treatments for all minors, regardless of sex, and concluded that Tennessee lawmakers could have rationally determined that the law was an appropriate response to perceived risks associated with the treatments. Sutton, a nominee of George W. Bush, also said courts should be wary of intervening in a highly contested political dispute. Judge Helene N. White, another Bush nominee, agreed with the majority that the Constitution envisions states acting as laboratories for democracies to resolve political debates, but dissented from the majority ruling. “When a fundamental right or freedom from discrimination is involved, experimentation has no place,” she wrote. At the Supreme Court, Solicitor General Elizabeth B. Prelogar is asking the justices to return the case to the 6th Circuit to apply a more stringent level of review, which she says should be triggered by a law that discriminates based on sex. The state, she wrote, ignores the benefits of gender-transition care and overstates the health risks. She also said the law’s stated goal of having teens “appreciate their sex” is based on stereotypical understandings of gender and cannot be used to justify the ban. Skrmetti, the Tennessee attorney general, said the state has the authority to protect minors from the risks of gender-transition treatment, and the federal government should not discount lawmakers’ concerns. He also objected to Prelogar’s characterization of the law as driven by stereotypes. It is not unconstitutional discrimination, Skrmetti argued, to say that drugs can be prescribed for one reason, but not another. L.W. will be in the courtroom on Wednesday, but she said she can’t comprehend the gravity of the case she’s a part of. Mostly, she has tried to continue to live the life gender care has made possible. The day the ACLU filed its petition, she went to high school, and she only told a few people in the Gender-Sexualities Alliance, or GSA, about the case. That night, she worried, briefly, that her name would be on a case that might be remembered along the same lines as Plessy v. Ferguson, the 1896 Supreme Court case that ruled it was constitutional for states to enact segregation laws. Eventually, L.W. decided it was out of her control, and plus, she had the drivers’ test for her learner’s permit to worry about, so she set aside her fears and let her lawyers handle the hard parts. She is a junior in high school now. She DJed a party this Halloween. She has broadened her social life, and she adopted a kitten the family named Mushroom. She wants to spend her free time traveling to look at colleges with aviation programs, but for now, she and her mother still make regular trips to get treatment in North Carolina. Traveling out of state for health-care she’d rather get at home is arduous. Until recently, her mother had to take unpaid time off work, and L.W. has to call in sick to the magnet high school where she takes three Advanced Placement classes. “I hate taking days off school, it’s, like, the worst thing ever,” she said. “I have very, very difficult classes. So I’ve got a lot to catch up on if I miss a single day.” The drive used to take five hours each way, but Hurricane Helene washed out one of the roads they take, and now, the journey will be much longer. Comments are not available on this story. Send questions/comments to the editors. « Previous Next »

San Francisco (5-5) at Green Bay (7-3) Sunday, 4:25 p.m. EST, FOX BetMGM NFL odds: Packers by 2 1/2. Against the spread: 49ers 4-6; Packers 4-6 Series record: Packers lead 38-34-1 Last meeting: 49ers beat Packers 24-21 in NFC divisional playoff game Jan. 20, 2024, in Santa Clara, California. Last week: 49ers lost 20-17 at home to Seattle; Packers won 20-19 at Chicago 49ers offense: overall (2), rush (7), pass (4), scoring (T-8) Packers offense: overall (4), rush (4), pass (9), scoring (T-8) 49ers defense: overall (6), rush (8), pass (8), scoring (T-16) Packers defense: overall (12), rush (14), pass (13), scoring (10) Turnover differential: 49ers plus-3; Packers plus-5 49ers player to watch QB Brandon Allen: With Brock Purdy unavailable due to a sore right shoulder, Allen will make his first start in three years. The 32-year-old Allen has made nine career starts, and his teams have gone 2-7 in those games. His last start came with Cincinnati in the 2021 regular-season finale when the Bengals rested usual starter Joe Burrow to get ready for the playoffs. Allen has thrown three passes in the last three seasons, including none since joining San Francisco in 2023. Allen was a member of the Los Angeles Rams in 2017, when Packers coach Matt LaFleur was that team’s offensive coordinator. Packers player to watch RB Josh Jacobs has 838 yards rushing this season to rank third in the NFL entering Week 12. He ran for 76 yards and a touchdown while also catching five passes for 58 yards against the Bears. Jacobs has scored four touchdowns (three rushing, one receiving) over his past four games. He has at least 90 yards from scrimmage over his past six games, matching Houston’s Joe Mixon for the NFL’s longest such active streak. Key matchup 49ers RB Christian McCaffrey vs. Packers run defense: McCaffrey rushed for 98 yards and two touchdowns — including the game-winner with 1:07 left — in the 49ers’ playoff victory over the Packers last season. Green Bay is coming off a performance in which it allowed a season-high 179 yards rushing to the Bears. Key injuries Purdy isn't playing due to a sore throwing shoulder. ... The 49ers also won't have Nick Bosa after he injured his left hip and oblique against the Seahawks. ... Niners CB Charvarius Ward will miss a third straight game following the death of his 1-year-old daughter. ... Niners LT Trent Williams (ankle) is questionable. ... Niners TE George Kittle is expected back after missing last week’s game with a hamstring injury. ... Packers CB Jaire Alexander (knee) and LB Edgerrin Cooper (hamstring) have been ruled out. ... Packers guard Jordan Morgan (shoulder) is on injured reserve. Series notes The 49ers have beaten the Packers in the playoffs three of the past five years. That includes a 37-19 victory in the 2019 NFC championship, a 13-10 upset at Lambeau Field in the 2021 divisional round and the 24-21 thriller last season. The past three matchups between these teams — including a Packers 30-28 road victory on Sept. 26, 2021 — have been decided by a total of eight points. This marks the first time these teams have faced off at Lambeau Field during the regular season since a Packers 33-30 triumph on Oct. 15, 2018. Each of the past three Packers-49ers games at Green Bay have been decided by three points. 49ers coach Kyle Shanahan and Packers coach Matt LaFleur worked together as assistants at Houston (2008-09), Washington (2010-13) and Atlanta (2015-16). Stats and stuff A loss would give the 49ers a losing record more than 10 games into a season for the first time since going 6-10 in 2020. ... San Francisco has lost a league-worst three games this season after leading in the final two minutes of regulation. ... The 49ers have allowed 36 points in the final two minutes of regulation, second most in the NFL. ... The Niners had only one play from scrimmage go for at least 20 yards last week, tied for the fewest in any game in eight seasons under Shanahan. ... San Francisco is outgaining the opposition through the air by an NFL-best 53.9 yards per game. ... McCaffrey has topped 100 yards from scrimmage in his first two games back from Achilles tendinitis and has five straight games with at least 100 yards from scrimmage going back to last postseason. ... McCaffrey’s 57 games with at least 100 yards from scrimmage are the most for any active player. ... The 49ers are 1-5 this season when Purdy turns the ball over and 4-0 when he doesn’t. ... Purdy’s four rushing TDs are the most in a season for a Niners QB since Colin Kaepernick had four in 2013. ... This is the first of three games the Packers are playing in a 12-day stretch. They host the Miami Dolphins on Thanksgiving night and visit the NFC North-leading Detroit Lions on Dec. 5. ... The Packers are tied for fourth in the league with 19 takeaways, but they don’t have any over their past two games. ... Packers S Xavier McKinney has six interceptions this season to rank second in the league, behind Detroit’s Kerby Joseph (seven). McKinney has seven total takeaways, putting him in a tie for first with Joseph. ... Jacobs’ 838 yards rushing and 1,024 scrimmage yards this season are the most any Packer has had in his first 10 games with the team. Jacobs’ 1,024 scrimmage yards are the most for any Packer through the first 10 games of a season since Ahman Green had 1,057 at this point in 2004. ... Packers DL Rashan Gary had his 35th sack against Chicago to overtake teammate Kenny Clark for ninth place in franchise history. Clark, a three-time Pro Bowl selection, is still seeking his first sack of the season. ... The Packers and 49ers have the NFC’s best regular-season winning percentage since 2019. The Packers are 63-30 and the 49ers 59-34 during that stretch. ... San Francisco’s George Kittle has seven touchdown catches to lead all NFL tight ends. Green Bay’s Tucker Kraft has five touchdown receptions to match Baltimore’s Mark Andrews for the second-highest total among tight ends. ... The 49ers rank 26th in the league with TDs on 48.8% of their red zone drives. Green Bay is 27th in that category and has scored TDs on 48.7% of its drives. Fantasy tip Packers WR Christian Watson’s slow start to the season means he might have been stashed on someone’s bench or perhaps even became available on some fantasy football waiver wires. Now would be a good time to try to acquire him. Watson had four catches for a career-high 150 yards against the Bears. After getting targeted just 14 times over his first six games, Watson’s had 17 targets in his past three. He had a catch each of the four times Jordan Love targeted him in Chicago. ___ AP NFL: https://apnews.com/hub/NFL The Associated Press

Biden's Unconditional Pardon: A Controversial MoveJefferson keeps seeing double as Vikings aim to stay focused on overall offensive production

ORCHARD PARK — Ja’Marcus Ingram stood on the sidelines, but don’t say he wasn’t part of the game. The Buffalo Bills cornerback listens for the defensive call, then he looks to see what formations and motion the offense is showing. Once the ball is snapped, Ingram’s eyes are locked on the cornerbacks, looking not only at what they are doing, but what he would do if he was in the game. Ingram played 87 snaps over the first four games in Buffalo’s dime package while Taron Johnson recovered from a broken forearm. Since Johnson returned in Week 6, though, Ingram played 11 total defensive snaps over eight weeks. That changed early in the fourth quarter when starter Rasul Douglas left with a knee injury, and with Kaiir Elam inactive, Ingram was the next man in line. Ingram played an uneventful 16 snaps to finish the game, aside from a pass interference penalty on third down that coach Sean McDermott felt was a poor call. Douglas did not practice Wednesday and if he can’t play, Ingram is likely to be thrust into the starting lineup against the Detroit Lions and the highest scoring offense in the NFL. It’s a moment Ingram has been thinking about, . “It was tough because you go from playing a lot on defense to not really playing that much,” Ingram told GNN Sports. “But it’s kind of understood with what the next step is with my role changing from defense to strictly special teams. ... It’s more like a competitive thing. You’re like, ‘I want to be out there on defense.’ But at the same time, I make the shift to special teams, I’m like, ‘All right. I’m going to go dominate special teams.’” The #Bills and #Sabres had a forgettable weekend. @billhoppe.bsky.social and I get into Allen's historic game, McDermott's tough day and postgame comments, the Sabres' skid and Kevyn Adams's press conference. fireside.fm/episode/sMvb... The University at Buffalo product made a splash in his first two games after making the 53-man roster. He made a game-saving pass break-up on the final defensive play of the game against the Arizona Cardinals in Week 1. He followed that with two interceptions, one returned for a touchdown, against the Miami Dolphins the next week. Almost 20 pounds lighter than Douglas, Ingram matches him in length and height at 6-foot-2. But Ingram has shown the versatility to play outside or in the slot, while being a willing tackler against the run. “You saw some of the production early,” McDermott said. “Pick-six he had and his hands on the ball. Making the play in the Arizona game to help us seal the game there. He’s physical in the run game. So, like all of us, we’ve got things to work on.” Throughout minicamp and training camp, Ingram was the No. 4 cornerback on the roster. That held true into the season, including when starter Christian Benford was injured and Elam started against Miami in Week 9. But over the last three games, Ingram has jumped Elam on the depth chart. Elam, a 2022 first-round pick who has been in and out of McDermott’s doghouse with inconsistent play and injuries, has been a healthy scratch the last three games. When McDermott was asked if Elam was not competing enough, he responded, “Maybe that, maybe some other players have earned it more.” “Everything’s earned,” McDermott said. “That’s part of every decision, a big part of every decision, for most of the reasons of who is active or inactive and whatnot. Everything’s earned and will continue to be earned as we move forward this week and we’ll see where it goes.” Aside from his start against the Dolphins, Elam has played 31 defensive snaps all season. It comes a year after being a healthy scratch seven times, . Before his stint on IR, Elam started two games and labored with the injury. He was also in and out of the lineup as a rookie. . He’s got four career interceptions and two have come in the playoffs, including an interception of Mason Rudolph in the end zone during an AFC wild-card win over the Pittsburgh Steelers last season. Elam says the coaching staff reasoned his latest demotion due to numbers not being on par with the other cornerbacks. And that he wasn’t making enough plays during practice, which left Elam wondering how to get back into Buffalo’s good graces. “Coming to work every day, I work hard, I compete, I do what’s asked of me and make plays in practice,” Elam told GNN Sports at his locker Wednesday. “That’s all I can do is control the controllables. I really don’t have any answers.” Elam is still one of the last players off the practice field each day, often putting in extra time with Benford and Douglas. He’s also present in games, even if he’s inactive. During games, Elam can be seen on the sidelines talking to Benford and Douglas to understand what they are seeing on the field and offering tidbits that he’s gleaned from his view from afar. “I’m placed on this earth for a bigger reason,” Elam said. “If I’m not given the opportunity to play or start, I’m going to pour myself into my teammates no matter what. Those guys are trying to feed their family just as I am if I was on the field. So if those guys need extra eyes ... I just try anything that they need help on.” CB Rasul Douglas (knee) and S Taylor Rapp (neck/shoulder) did not participate in Wednesday’s walk-through. ... DE Casey Toohill (ribs) was limited. ... The Bills also opened 21-day windows for LB Baylon Spector (calf) and DE Dawuane Smoot (wrist) to return from injured reserve and both practiced in full.

HUNTSVILLE, Ala. (AP) — Alabama A&M fired football coach Connell Maynor after seven seasons on Monday. Athletic director Paul A. Bryant announced the decision in a statement. The Bulldogs went 6-6 this season, including a 4-4 Southwestern Athletic Conference mark, and won three straight games before a season-ending loss to Florida A&M. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

Commanders release yet another former first-round pick from Ron Rivera era, place RB Austin Ekeler on IRPublished 5:09 pm Friday, November 22, 2024 By Jan Griffey NATCHEZ — Natchez lost a native son on Nov. 14, when Aubrey Bernell “B.J.” Norman Jr. died after suffering a seizure. He was 41. Born and raised in Natchez to Aubrey Bernell Norman Sr. and Shirley Bland Norman, Norman was a proud graduate 2001 Natchez High School, where he was elected Mr. Natchez High. “He was a Natchez boy through and through. He was so proud of his hometown. He always told people how he was from Natchez,” said his former wife, Ashleigh Crosby Norman. The pair ended their marriage about a year ago, but remained best friends and co-parented their three children — Aubrey III, 16, and 10-year-old twins, Alton and Ava. Norman, who lived in Ridgeland, was known in the restaurant community in Jackson as a celebrity chef. During his young career, he opened and operated several restaurants, including the Downtown Cafe in 2010. Normal also hosted a cooking segment on Jackson’s Fox 40. After attending Hinds Community College and Jackson State University, where he studied business, Norman went to work as a night auditor at the Marriott. He learned every aspect of that business, Ashleigh said, and went to work at the popular upscale Steam Room Grill. “The owners took a liking to him and he worked as a bartender and server and became assistant manager. He learned everything from the front of the house to the back of the house,” she said. The two got married in 2007, which is when Norman began developing his vision of opening a restaurant. “That was the beginning of his entrepreneurship journey. He opened Downtown Cafe in 2010 and went on to open several restaurants,” she said. However, Norman had a health setback in 2021 when he suffered a stroke. “He suffered his first stroke in 2021 and was left with some physical impairments, but he was super positive,” Ashleigh said. “He was unable to do all of his catering, but he learned to pivot and turned Downtown Cafe into a consulting company and helped numerous businesses, particularly small Black businesses. He was an expert. He did everything from setting up payment systems to training staff.” In all, Norman is credited with helping open 20 restaurants in Mississippi. In fact, Norman was named recently to the Top 50 under 50 of Mississippi’s Urban Elite Professionals. He was to be presented that honor at a gala on Jan. 25, 2025. Norman was at his oldest son’s basketball game on Nov. 5 when he suffered a seizure from which he did not recover. He died on Nov. 14. “He loved his children. He did not miss a game or a match or a practice. He loved to cook, and our children get that from him. He was so proud of everything they did. He loved to watch people operate in their craft. He said people should figure out how they can use that and share it with the world,” Ashlee said. “He was a blessing to us all and he will be so, so missed. Family visitation for Norman is Tuesday from 5 to 6 p.m. at Marshall Funeral Home, 225 Pilgrim Blvd., Natchez. A Good Times and Great Memories social hour will be held on Tuesday beginning at 7 p.m. at Doll Baby’s, 6 Saint Catherine St. A celebration of life is Wednesday at 11 a.m. at Pilgrim Baptist Church with reserved seating for the Natchez High School Class of 2001. Burial will follow in Greenlawn Cemetery. A repast will follow at Pilgrim Baptist Church.

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