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MIAMI GARDENS, Fla. (AP) — Mike McDaniel has seen a change in quarterback Tua Tagovailoa over the past month. “He's found a way to improve the way he plays the position throughout the game,” the Dolphins coach said Sunday, after Tagovailoa threw for four touchdowns in a dominant 34-15 win over the New England Patriots. “The most monumental thing that you have to overcome as a quarterback is playing the position regardless of the ebbs and flows," McDaniel added, "so not changing how you play based upon positive or negative results and letting every play stand on its own.” Tagovailoa has mastered that ability to remain even-keeled during Miami's three-game winning streak, McDaniel noted, highlighted by his 317-yard passing performance on Sunday. The Dolphins (5-6) have a thin margin for error the rest of the season but have kept themselves afloat with a strong stretch that includes two-straight 30-point games. With their win at New England (3-9) in Week 5, the Dolphins have swept their division rivals in consecutive seasons for the first time since 1999-2000. Tagovailoa, who moved to 7-0 in his career against New England, entered the game with a league-high 73.4% completion rate and went 29 for 40. He has 11 passing touchdowns and just one interception since returning from injured reserve in Week 8. “We’re still below the .500 threshold, and it’s a long way to where we want to get to," Tagovailoa said. “We’ll enjoy this win, but this next one is going to be big for us.” The Dolphins have a short turnaround with a game at Green Bay on Thursday. Backup Skylar Thompson replaced Tagovailoa with about 11 minutes left in what was already a blowout, but a bad handoff on his first play resulted in a fumble that was recovered by cornerback Christian Gonzalez and returned 63 yards for a touchdown. It cut New England's deficit to 31-15, and Tagovailoa returned the next drive. Miami's defense held the rest of the way. Linebacker Tyrel Dodson intercepted rookie quarterback Drake Maye on New England's penultimate drive, then Miami stopped the Patriots on fourth down on the next. Jaylen Waddle caught eight passes for a season-high 144 yards and a 23-yard touchdown that stretched Miami's lead to 31-0 entering the fourth. Running back De'Von Achane scored on a 9-yard screen pass and then walked into the end zone for an 11-yard TD in the first half. Jonnu Smith finished with 87 yards on nine catches to continue his strong first season as a Dolphin. One week after catching two touchdowns with a career-high 101 yards receiving, Smith found the end zone for a 7-yard TD catch on the Dolphins' second drive. New England was shut out until tight end Austin Hooper got behind the Dolphins defense for a wide-open 38-yard touchdown catch from Maye to make it 31-7 with 13:43 left. Maye completed 22 of 37 passes for 221 yards with 26 yards rushing. But he couldn't overcome an overall sloppy performance by the Patriots in which they got nothing going offensively until the final quarter and had 10 penalties accepted against them. “I always say I hate losing more than I like to win," Maye said. "We got our butts whipped today, and it’s only up from here. We’ve got a bright future and the right players in there for the Patriots.” New England's best drive of the first half lasted 12 plays and covered 80 yards but included three accepted offensive penalties and ended in a missed 45-yard field goal by Joey Slye. The Patriots forced a Dolphins punt and moved down the field again on the opening drive of the second half, with Maye completing an improvised 10-yard throw on third down to receiver Kendrick Bourne. New England then tried a double pass with Bourne, whose cross-field throw fell short of Rhamondre Stevenson on 3rd-and-17. DeMario Douglas led the Patriots with 61 yards receiving. Antonio Gibson had six rushes for 30 yards. With the loss, the Patriots will finish their third straight season below .500. Its the first time since 1991-93 New England has had three straight losing seasons. “Once those guys cross the white lines, there’s nothing I can do for them,” coach Jerod Mayo said. "There’s nothing any coach can do for them. It’s my job to continue to prepare not only them, but our coaches as well.” Dolphins: LB Anthony Walker Jr. sustained a noncontact hamstring injury in the second quarter. He was helped slowly off the field by trainers and did not return. Patriots: Host Indianapolis next Sunday. Dolphins: At Green Bay on Thursday. AP NFL: https://apnews.com/hub/NFL
Acoltremon is under clinical development by and currently in Phase III for Keratoconjunctivitis Sicca (Dry Eye). According to GlobalData, Phase III drugs for Keratoconjunctivitis Sicca (Dry Eye) have a 26% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Acoltremon overview Acoltremon (AR-15512) is under development for the treatment of dry eye syndrome. It is administered through ophthalmic route as a solution. It acts by targeting TRPM8 receptor. It was also under development for vaginal dryness. Alcon overview is engaged in the development and manufacturing of devices in the field of ophthalmology. The company’s portfolio encompasses contact lenses and surgical products, including implantables, consumables and surgical equipment. The company’s products are indicated for the treatment of various conditions such as cataracts, glaucoma, retinal diseases and refractive errors. It conducts clinical trials to evaluate the safety and efficacy of its products for the prevention and cure of blindness and different eye diseases. ’s pipeline products are developed through collaboration with institutions, medical innovators, research advisors and academic thought leaders. The company has operations in the Americas, Europe, the Middle East, and Africa and Asia Pacific. is headquartered in Fribourg, Switzerland. For a complete picture of Acoltremon’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
Six-time Olympic gold medallist Emma McKeon has announced her retirement from competitive swimming as one of the most successful Australian athletes. The 30-year-old confirmed the news on her Instagram on Monday morning, saying she was "proud" and she had gave her swimming career "absolutely everything". "Today I am officially retiring from competitive swimming. Leading into Paris, I knew it would be my last Olympics, and the months since have given me time to reflect on my journey, and think about what I wanted my future to look like in swimming," she wrote. "I am proud of myself for giving my swimming career absolutely everything, both physically and mentally. I wanted to see what I was capable of - and I did." McKeon added she had been "given so much" since taking the sport up at the age of five through to representing Australia on the world stage at three consecutive Games. "I have so many lessons, experiences, friendships and memories that I am so thankful for. Along with every person who supported me, worked hard with me, and cheered me on. THANKYOU," she continued in the social media post. "Now I am excited to see how I can push myself in other ways, and for all the things that life has in store." The post was accompanied by a video showing her highlights in and out of the water. McKeon - who has won six golds, three silvers and five bronze medals at Rio, Tokyo and Paris - previously said she has a "love-hate" relationship with swimming. In her teenage years she stopped going to the pool, but quickly found out she missed being in the water, as well as "working hard for a goal". As her career grew she had to learn to cope with the pressure of the sport which included on missing out on making the Australian team at the 2012 London Games. McKeon won her first gold four years later at Rio, but it was not until 2021 during the COVID-interrupted Tokyo Games when she caught the world's attention. The then 27-year-old became the first woman to win seven medals at a Games, four of which were gold, and also set three Olympic records and one world record. Her first Olympic gold in the 100 metre freestyle in Rio is one of her highlights. McKeon struggled leading up to the Paris Games this year. She missed out on qualifying for her individual pet events in the Australia trials a few months before the Olympics, only advancing into the relays and the 100m butterfly. The champion swimmer did however help Australia win gold in the 4x100m freestyle alongside Mollie O'Callaghan, Shayna Jack and Meg Harris to beat the USA and China. This is a breaking story. More to come.
It was no different for Jimmy Carter in the early 1970s. It took meeting several presidential candidates and then encouragement from an esteemed elder statesman before the young governor, who had never met a president himself, saw himself as something bigger. He announced his White House bid on December 12 1974, amid fallout from the Vietnam War and the resignation of Richard Nixon. Then he leveraged his unknown, and politically untainted, status to become the 39th president. That whirlwind path has been a model, explicit and otherwise, for would-be contenders ever since. “Jimmy Carter’s example absolutely created a 50-year window of people saying, ‘Why not me?’” said Steve Schale, who worked on President Barack Obama’s campaigns and is a long-time supporter of President Joe Biden. Mr Carter’s journey to high office began in Plains, Georgia where he received end-of-life care decades after serving as president. David Axelrod, who helped to engineer Mr Obama’s four-year ascent from state senator to the Oval Office, said Mr Carter’s model is about more than how his grassroots strategy turned the Iowa caucuses and New Hampshire primary into his springboard. “There was a moral stain on the country, and this was a guy of deep faith,” Mr Axelrod said. “He seemed like a fresh start, and I think he understood that he could offer something different that might be able to meet the moment.” Donna Brazile, who managed Democrat Al Gore’s 2000 presidential campaign, got her start on Mr Carter’s two national campaigns. “In 1976, it was just Jimmy Carter’s time,” she said. Of course, the seeds of his presidential run sprouted even before Mr Nixon won a second term and certainly before his resignation in August 1974. In Mr Carter’s telling, he did not run for governor in 1966, he lost, or in 1970 thinking about Washington. Even when he announced his presidential bid, neither he nor those closest to him were completely confident. “President of what?” his mother, Lillian, replied when he told her his plans. But soon after he became governor in 1971, Mr Carter’s team envisioned him as a national player. They were encouraged in part by the May 31 Time magazine cover depicting Mr Carter alongside the headline “Dixie Whistles a Different Tune”. Inside, a flattering profile framed Mr Carter as a model “New South” governor. In October 1971, Carter ally Dr Peter Bourne, an Atlanta physician who would become US drug tsar, sent his politician friend an unsolicited memo outlining how he could be elected president. On October 17, a wider circle of advisers sat with Mr Carter at the Governor’s Mansion to discuss it. Mr Carter, then 47, wore blue jeans and a T-shirt, according to biographer Jonathan Alter. The team, including Mr Carter’s wife Rosalynn, who died aged 96 in November 2023, began considering the idea seriously. “We never used the word ‘president’,” Mr Carter recalled upon his 90th birthday, “but just referred to national office”. Mr Carter invited high-profile Democrats and Washington players who were running or considering running in 1972, to one-on-one meetings at the mansion. He jumped at the chance to lead the Democratic National Committee’s national campaign that year. The position allowed him to travel the country helping candidates up and down the ballot. Along the way, he was among the Southern governors who angled to be George McGovern’s running mate. Mr Alter said Mr Carter was never seriously considered. Still, Mr Carter got to know, among others, former vice president Hubert Humphrey and senators Henry Jackson of Washington, Eugene McCarthy of Maine and Mr McGovern of South Dakota, the eventual nominee who lost a landslide to Mr Nixon. Mr Carter later explained he had previously defined the nation’s highest office by its occupants immortalised by monuments. “For the first time,” Mr Carter told The New York Times, “I started comparing my own experiences and knowledge of government with the candidates, not against ‘the presidency’ and not against Thomas Jefferson and George Washington. It made it a whole lot easier”. Adviser Hamilton Jordan crafted a detailed campaign plan calling for matching Mr Carter’s outsider, good-government credentials to voters’ general disillusionment, even before Watergate. But the team still spoke and wrote in code, as if the “higher office” were not obvious. It was reported during his campaign that Mr Carter told family members around Christmas 1972 that he would run in 1976. Mr Carter later wrote in a memoir that a visit from former secretary of state Dean Rusk in early 1973 affirmed his leanings. During another private confab in Atlanta, Mr Rusk told Mr Carter plainly: “Governor, I think you should run for president in 1976.” That, Mr Carter wrote, “removed our remaining doubts.” Mr Schale said the process is not always so involved. “These are intensely competitive people already,” he said of governors, senators and others in high office. “If you’re wired in that capacity, it’s hard to step away from it.” “Jimmy Carter showed us that you can go from a no-name to president in the span of 18 or 24 months,” said Jared Leopold, a top aide in Washington governor Jay Inslee’s unsuccessful bid for Democrats’ 2020 nomination. “For people deciding whether to get in, it’s a real inspiration,” Mr Leopold continued, “and that’s a real success of American democracy”.The 49ers’ season is over. Ignore the nonsense being pushed about this team winning out and making the playoffs. Cue the famous Jim Mora Sr. soundbite: “Playoffs? Playoffs? You kidding me? Playoffs? I just hope we can win a game.” And yet there is so much to play for in the season’s final five games. The beauty of the NFL is that every week, everyone is playing for their jobs. You’re either getting better or getting worse, and you don’t want to be in the latter category ahead of what should be a dramatic, resetting offseason in Santa Clara, Calif. So, in the final weeks, the young players who are now given a shot at serious playing time because of injury or a depth chart reshuffle need to point their arrows up. The older players, whose arrows might be pointing down, need to level out. Coaches have five weeks to prove they’re not this team’s problem. Oh, and then there’s the $60 million-per-season question that still needs to be answered. The 49ers brass — Kyle Shanahan, John Lynch, and CEO Jed York chief among them — have not wavered on their commitment to quarterback Brock Purdy. (By all accounts, York has not wavered on Shanahan or Lynch, either.) The money for a massive contract extension is budgeted for this upcoming offseason. But, at the risk of over-legitimizing it, the question of whether the Niners should hand Purdy that massive new contract still lingers among the fan base and the media. And it’s not just the unhinged portions of those groups pushing that idea, either. That’s not to be overlooked. As we found out with the Trey Lance draft pick, the Niners’ brass can be influenced by both fans and the media. (We’ll all take the L on that one.) So, while the money is ready, the contract hasn’t been drawn up just yet, and it’s more than fair to say that Purdy’s arrow, perhaps for the first time in his short NFL career, is pointing down. It’s on him in the final five games to flip it and make paying him a no-brainer decision for everybody. Yes, $60 million a year is an eye-watering number. Blame inflation. It seems like just yesterday that Jimmy Garoppolo signed a market-setting deal that paid him $27 million per season. Now we’re doubling it? Maybe Garoppolo isn’t the best example, but it’s easy to see why this kind of number sits wrong with so many people. However, the NFL’s salary cap — which rose 13 percent from 2023 to 2024 — has added nearly $100 million since the 49ers signed Garoppolo in 2018. And it’s not as if the importance of competent quarterbacking has diminished since then. These days, high-school quarterbacks spark eight-figure contract bidding wars. I understand the concerns about paying a quarterback top-of-the-line money for not top-of-the-line production, but not everyone gets a Patrick Mahomes or Josh Allen. This is a league where Dak Prescott makes $60 million per season, Tua Tagovailoa makes $53 million, Trevor Lawrence makes $55 million, and Kirk Cousins makes $45 million. The market is set. It’s not hard to figure out where Purdy fits. The 24-year-old quarterback might be having a down year, but he’s still a hell of a player. His scrambling ability is a critical reason why the Niners have not yet been mathematically eliminated from playoff contention. The coaches’ All-22 film is far more forgiving of his play than the zoomed-in broadcast view. Either way, what’s the alternative to paying Purdy for the 49ers? Draft another quarterback? For every Purdy, there’s a Lance. There’s a C.J. Beathard, too. Sign 2023’s backup quarterback Sam Darnold to a short-term mid-tier deal (somewhere in the $35 million-per-year range)? In the best-case scenario, you’ll have to pay him like Purdy — more than Purdy, in fact — in a year or two. Worst-case scenario, everyone (who can be fired) is fired for letting Purdy walk out the door and not having a viable replacement. Personally, I would have no problem with delaying Purdy’s signing for as long as possible. Make him play out the fourth and final year of his rookie contract at $1.19 million, and then go full Cousins and franchise tag him once or twice. But that’s an easy tactic to take in Madden or a column. It’s a bit more challenging to pull with a quarterback you have to see every day. Nothing says “We trust you to lead this team,” like having a guy on a temp-worker contract. The word “toxic” comes to mind. The Niners believe in rewarding their best players with market-setting contracts. They should. But they should have learned a lesson from this past summer that it’s in no one’s best interest to delay that gratification. I imagine they’ll sign Purdy to his new deal shortly after the season. No fuss, no muss. The young quarterback must find a way in the final five weeks to ensure that such an agreement on his value extends beyond the team facility. ©2024 MediaNews Group, Inc. Visit at mercurynews.com . Distributed by Tribune Content Agency, LLC.
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The Musk-Led Manufacturing Revolution Nobody Is Talking AboutA HYBRID tomato variety developed by the Mariano Marcos State University (MMSU) has proven resilient amid the wet season and back-to-back typhoons this year. Jesslyn Keith Valite of MMSU Strategic Communication Office said this was showcased during a technology demonstration on Dec. 16 at Pastor Wilmar Miguel's farm in Barangay Saricao in Vintar, Ilocos Norte, proving that fresh tomatoes can be enjoyed year-round. Register to read this story and more for free . Signing up for an account helps us improve your browsing experience. OR See our subscription options.
Giants release quarterback Daniel Jones just days after benching him EAST RUTHERFORD, N.J. (AP) — The Daniel Jones era in New York is over. The Giants quarterback was granted his release by the team just days after the franchise said it was benching him in favor of third-stringer Tommy DeVito. New York president John Mara said Jones approached the team about releasing him and the club obliged. Mara added he was “disappointed” at the quick dissolution of a once-promising relationship between Jones and the team. Giants coach Brian Daboll benched Jones in favor of DeVito following a loss to the Panthers in Germany that dropped New York's record to 2-8. Conor McGregor must pay $250K to woman who says he raped her, civil jury rules LONDON (AP) — A civil jury in Ireland has awarded more than $250,000 to a woman who says she was raped by mixed martial arts fighter Conor McGregor in a Dublin hotel penthouse after a night of heavy partying. The jury on Friday awarded Nikita Hand in her lawsuit that claimed McGregor “brutally raped and battered” her in 2018. The lawsuit says the assault left her heavily bruised and suffering from post-traumatic stress disorder. McGregor testified that he never forced her to do anything and that Hand fabricated her allegations after the two had consensual sex. McGregor says he will appeal the verdict. Week 16 game between Denver Broncos and Los Angeles Chargers flexed to Thursday night spot The Los Angeles Chargers have played their way into another prime time appearance. Justin Herbert and company have had their Dec. 22 game against the Denver Broncos flexed to Thursday night, Dec. 19. Friday’s announcement makes this the first time a game has been flexed to the Thursday night spot. The league amended its policy last season where Thursday night games in Weeks 13 through 17 could be flexed with at least 28 days notice prior to the game. The matchup of AFC West division rivals bumps the game between the Cleveland Browns and Cincinnati Bengals to Sunday afternoon. NBA memo to players urges increased vigilance regarding home security following break-ins MIAMI (AP) — The NBA is urging its players to take additional precautions to secure their homes following reports of recent high-profile burglaries of dwellings owned by Milwaukee Bucks forward Bobby Portis and Kansas City Chiefs teammates Patrick Mahomes and Travis Kelce. In a memo sent to team officials, a copy of which was obtained by The Associated Press, the NBA revealed that the FBI has connected some burglaries to “transnational South American Theft Groups” that are “reportedly well-organized, sophisticated rings that incorporate advanced techniques and technologies, including pre-surveillance, drones, and signal jamming devices.” Brock Purdy will miss Sunday's game for the 49ers with a shoulder injury SANTA CLARA, Calif. (AP) — San Francisco 49ers quarterback Brock Purdy will miss Sunday’s game against the Green Bay Packers with a sore throwing shoulder. Purdy injured his right shoulder in last Sunday’s loss to the Seattle Seahawks. Purdy underwent an MRI that showed no structural damage but the shoulder didn’t improve during the week and Purdy was ruled out for the game. Coach Kyle Shanahan said star defensive end Nick Bosa also will miss the game with injuries to his left hip and oblique. Left tackle Trent Williams is questionable with an ankle injury and will be a game-time decision. Red Bull brings wrong rear wing to Las Vegas in mistake that could stall Verstappen's title chances LAS VEGAS (AP) — Max Verstappen is suddenly in jeopardy of being denied a fourth consecutive Formula 1 title Saturday night. Red Bull apparently brought the wrong rear wing to Las Vegas and GPS data showed its two cars to be significantly slower on the straights than both McLaren and Mercedes, which led both practice sessions. Red Bull says it doesn’t have a replacement rear wing in Las Vegas to fix the issue and little chance of getting two flown in from England ahead of the race. Lawyer says ex-Temple basketball standout Hysier Miller met with NCAA for hours amid gambling probe PHILADELPHIA (AP) — A lawyer for former Temple basketball standout Hysier Miller says the 22-year-old sat for a long interview with the NCAA amid an investigation into unusual gambling activity. But neither the lawyer nor federal law enforcement officials on Friday would confirm reports that a federal probe is now under way. Lawyer Jason Bologna says Miller cooperated because he hopes to play again. Miller was released last month after transferring to Virginia Tech. Temple President John Fry says the Philadelphia school has not been asked for any information from federal law enforcement officials. Caitlin Clark to join Cincinnati bid for 16th National Women's Soccer League team WNBA star Caitlin Clark has joined Cincinnati’s bid for an expansion National Women’s Soccer League team. Major League Soccer franchise FC Cincinnati is heading the group vying to bring a women’s pro team to the city. The club issued a statement confirming Clark had joined the bid group. NWSL Commissioner Jessica Berman has said the league plans to announce the league’s 16th team by the end of the year. The league's 15th team will begin play in 2026 in Boston. Alyssa Nakken, first full-time female coach in MLB history, leaving Giants to join Guardians CLEVELAND (AP) — Alyssa Nakken, the first woman to coach in an MLB game, is leaving the San Francisco Giants to join the Cleveland Guardians. Nakken made history in 2022 when she took over as first-base coach following an ejection. A former college softball star at Sacramento State, Nakken joined the Giants in 2014 and was promoted to a spot on manager Gabe Kapler’s staff in 2020, becoming the majors’ first full-time female coach. Nakken has been hired as an assistant director within player development for the Guardians, who won the AL Central last season under first-year manager Stephen Vogt. Nakken, 34, will work with former Giants coaches Craig Albernaz and Kai Correa. Aaron Judge won't be bothered if Juan Soto gets bigger contract from Yankees than his $360M deal NEW YORK (AP) — Aaron Judge won’t be bothered if Juan Soto gets a bigger deal from the New York Yankees than the captain’s $360 million, nine-year contract. Speaking a day after he was a unanimous winner of his second MVP, Judge says “It ain’t my money” and adds "that’s never been something on my mind about who gets paid the most.” Judge led the major leagues with 58 homers, 144 RBIs and 133 walks while hitting .322. Soto batted .288 with 41 homers, 109 RBIs and 129 walks in his first season with the Yankees, then became a free agent at age 26.Unearthed footage of Barron Trump speaking with mom's accent spreads like wildfire after dad's massive win