Jason Kelce's wife announces she is pregnant with the couple's fourth child Former Philadelphia Eagles center Jason Kelce's wife is announcing she's pregnant with the couple's fourth child. Kylie Kelce posted a photo on Instagram on Friday of the couple's three young daughters reacting to the news. The oldest daughter, Wyatt, appears to be cupping her head in shock. The middle daughter, Ellioette, is smiling. The youngest, Bennett, is in tears. A caption attached to the photo reads: “I feel like we captured a very accurate representation of how each of the girls feel about getting another sister. At least Ellie, mom and dad are on the same page!” Israeli-Moldovan rabbi living in UAE is missing. Israeli officials fear he may have been kidnapped DUBAI, United Arab Emirates (AP) — An Israeli-Moldovan rabbi living in the United Arab Emirates has gone missing, with Israeli authorities raising the suspicion he may have been kidnapped as tensions remain high with Iran. The Israeli prime minister’s office said that Zvi Kogan has been missing since noon Thursday. It said that against the backdrop of information that this was a terrorist incident, an extensive investigation has been opened in the country. Emirati officials did not immediately respond to a request for comment Saturday. State-run media in the UAE, an autocratic federation of seven sheikhdoms on the Arabian Peninsula and home to Abu Dhabi and Dubai, did not immediately report the incident. Alyssa Nakken, first full-time female coach in MLB history, leaving Giants to join Guardians CLEVELAND (AP) — Alyssa Nakken, the first woman to coach in an MLB game, is leaving the San Francisco Giants to join the Cleveland Guardians. Nakken made history in 2022 when she took over as first-base coach following an ejection. A former college softball star at Sacramento State, Nakken joined the Giants in 2014 and was promoted to a spot on manager Gabe Kapler’s staff in 2020, becoming the majors’ first full-time female coach. Nakken has been hired as an assistant director within player development for the Guardians, who won the AL Central last season under first-year manager Stephen Vogt. Nakken, 34, will work with former Giants coaches Craig Albernaz and Kai Correa. Officer kills pet dog mistaken for a coyote in Massachusetts town. The owner says it was unnecessary An animal control officer shot and killed a pet dog in a Massachusetts town after mistaking it for a coyote in an incident local police are describing as a sad mix-up. Police in Northbridge, Massachusetts, say the shooting happened on Tuesday after police received a call of a report of a coyote in a residential backyard. Police say the animal control officer went into the woods to look for the coyote and found what they thought was the animal in a threatening position and shot it. The incident happened as communities around Massachusetts and the country have dealt with an uptick in interactions between coyotes and people. Kendrick Lamar surprises with new album 'GNX' LOS ANGELES (AP) — Kendrick Lamar gave music listeners an early holiday present with a new album. The Grammy winner released his sixth studio album “GNX” on Friday. The 12-track project is the rapper’s first release since 2022’s “Mr. Morale & The Big Steppers.” Lamar’s new album comes just months after his rap battle with Drake. The rap megastar will headline February's Apple Music Super Bowl Halftime Show in New Orleans. The 37-year-old has experienced massive success since his debut album “good kid, m.A.A.d city” in 2012. Since then, he’s accumulated 17 Grammy wins and became the first non-classical, non-jazz musician to win a Pulitzer Prize. NBA memo to players urges increased vigilance regarding home security following break-ins MIAMI (AP) — The NBA is urging its players to take additional precautions to secure their homes following reports of recent high-profile burglaries of dwellings owned by Milwaukee Bucks forward Bobby Portis and Kansas City Chiefs teammates Patrick Mahomes and Travis Kelce. In a memo sent to team officials, a copy of which was obtained by The Associated Press, the NBA revealed that the FBI has connected some burglaries to “transnational South American Theft Groups” that are “reportedly well-organized, sophisticated rings that incorporate advanced techniques and technologies, including pre-surveillance, drones, and signal jamming devices.” Ancient meets modern as a new subway in Greece showcases archaeological treasures THESSALONIKI, Greece (AP) — Thessaloniki, Greece’s second-largest city, is opening a new subway system, blending ancient archaeological treasures with modern transit technology like driverless trains and platform screen doors. The project, which began in 2003, uncovered over 300,000 artifacts, including a Roman-era thoroughfare and Byzantine relics, many of which are now displayed in its 13 stations. Despite delays caused by preserving these findings, the inaugural line has been completed, with a second line set to open next year. Conor McGregor must pay $250K to woman who says he raped her, civil jury rules LONDON (AP) — A civil jury in Ireland has awarded more than $250,000 to a woman who says she was raped by mixed martial arts fighter Conor McGregor in a Dublin hotel penthouse after a night of heavy partying. The jury on Friday awarded Nikita Hand in her lawsuit that claimed McGregor “brutally raped and battered” her in 2018. The lawsuit says the assault left her heavily bruised and suffering from post-traumatic stress disorder. McGregor testified that he never forced her to do anything and that Hand fabricated her allegations after the two had consensual sex. McGregor says he will appeal the verdict. At least 19 people are sick in Minnesota from ground beef tied to E. coli recall U.S. health officials say at least 19 people in Minnesota have been sickened by E. coli poisoning tied to a national recall of more than 167,000 pounds of potentially tainted ground beef. Detroit-based Wolverine Packing Co. recalled the meat sent to restaurants nationwide. Minnesota state agriculture officials reported multiple illnesses and found that a sample of the product tested positive for E. coli, which can cause life-threatening infections. No illnesses have been reported outside of Minnesota. Symptoms of E. coli poisoning include fever, vomiting, diarrhea and signs of dehydration. Actor Jonathan Majors’ ex-girlfriend drops assault and defamation lawsuit against once-rising star NEW YORK (AP) — Jonathan Majors’ ex-girlfriend has dropped her assault and defamation lawsuit against the once-rising Hollywood star after reaching a settlement. Lawyers for Majors and Grace Jabbari agreed to dismiss the case with prejudice Thursday. Jabbari is a British dancer who had accused Majors of subjecting her to escalating incidents of physical and verbal abuse during their relationship. Representatives for Majors didn’t respond to emails seeking comment Friday. Jabbari’s lawyer said the suit was “favorably settled” and her client is moving on with “her head held high.” Majors was convicted of misdemeanor assault and harassment last December and sentenced to a yearlong counseling program.8. Harmony Park Avenue
4. Crash diets: Quick-fix diets promising rapid weight loss may seem appealing, but they often result in short-term success followed by long-term weight gain. Crash diets can wreak havoc on your metabolism, leading to muscle loss, nutrient deficiencies, and a cycle of yo-yo dieting. Instead of resorting to extreme dieting tactics, focus on making sustainable lifestyle changes that promote gradual and lasting weight loss. Adopting a balanced diet and regular exercise routine can help you achieve and maintain a healthy weight over time.
As we reach the final "one" in December, the observations made during this month play a significant role in confirming the predictions for the upcoming winter season. If December is marked by frequent snowfall and strong winds, it is seen as a confirmation of a harsh winter with freezing temperatures. In contrast, a calm and relatively mild December might signal a more temperate winter with less extreme weather conditions. The cumulative observations made in October, November, and December help farmers and communities anticipate and adapt to the challenges of the winter season.Everything seemed to be going Ohio State’s way in the leadup to Saturday’s clash with bitter rival Michigan. The No. 2-ranked Buckeyes had a healthy roster and were hosting a Michigan team without star tight end Colston Loveland and cornerback Will Johnson — arguably the Wolverines’ top players on offense and defense, respectively. But despite Michigan being depleted from a talent standpoint and the Buckeyes one win away from locking up a sport in the College Football Playoffs, the Wolverines rode an inspired defensive effort to a huge upset of their archrivals, which could have thrown a wrench in OSU’s CFP hopes. Though Ohio State quarterback Will Howard remaining confident the Buckeyes would still get into the 12-team CFP field, the senior signal-caller shouldered a lot of the blame for OSU’s fourth straight loss to Michigan, publicly apologizing to his teammates for not leading them to victory. “I don't know if I have the answer to that at this moment,” Howard said of what he planned to tell his teammates, via Chase Brown of 11 Warriors. “Man, I still love this team. I still love this university... I'm sorry... I'm blessed to have the opportunity to be a Buckeye. I'm sorry I couldn't get this one done.” Adam Cairns/Columbus Dispatch / USA TODAY NETWORK via Imagn Images Howard played his worst game of the season against the Wolverines, finishing with just 175 yards, a touchdown and two interceptions — his first multi-interception game as a Buckeye — and he averaged a lowly 5.3 yards per pass attempt. He also completed a season-low 57.6% of his passes with his lowest passer rating of the year as well. On Ohio State’s final drive, Howard completed just 1 of his 5 passes for one yard. He completed 6 of his final 14 passes for 50 yards in the second half.Exciting news has recently emerged from the gaming world as the highly anticipated new title "Fading Radiance" is confirmed to make its debut at The Game Awards (TGA). This revelation has sent ripples of excitement through the gaming community, with players' anticipation levels skyrocketing to new heights.
Liu Dameili, also known as "Big Beauty Liu," gained fame on social media platforms for her beauty tips and skincare routines. Her sudden and tragic death has sparked concerns among her followers and the general public. Reports suggest that Liu Dameili may have been using unregulated beauty products or undergoing risky cosmetic procedures, leading to her untimely demise.In conclusion, Double 12 has become a platform for e-commerce players to shine and attract customers with exciting promotions and innovative marketing tactics, ultimately stimulating domestic demand and driving economic growth. With the digital shopping landscape evolving rapidly, e-commerce platforms must continue to innovate and adapt to meet the changing needs and preferences of consumers in order to thrive in the competitive market. As Double 12 comes to a close, the impact of this shopping festival will resonate throughout the e-commerce sector, setting the stage for future growth and innovation in the industry.
In conclusion, the reappearance of "moderately loose" in discussions around monetary policy signals a potential shift in policy stance towards a more accommodative position. While this move may be driven by various factors, including economic conditions and communication strategy, it is crucial for policymakers to tread carefully and implement measures that strike a balance between supporting growth and maintaining stability in the economy.During a recent art performance, a drone unexpectedly crashed, prompting renowned artist Cai Guo-Qiang to make a plea to the audience not to bring it home as a souvenir. The incident, while regrettable, thankfully concluded without causing any harm to individuals in attendance.
December 5, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Katie Brady, University of Illinois at Urbana-Champaign In a recent study published in Nature Communications , a team of researchers at the Carl R. Woese Institute for Genomic Biology reports a new, robust computational toolset to extract biological relationships from large transcriptomics datasets. These efforts will help scientists better investigate cellular processes. Living organisms are governed by their genome—an instruction manual written in the language of DNA that dictates how an organism grows, survives, and reproduces. By regulating the abundance of different RNA transcripts, cells control their protein expression level, thereby shaping their functions and responses to the environment. Transcriptomics is the study of gene expression through cataloging the presence and abundance levels of active RNA transcripts generated from the genome under different conditions. Through the lens of RNA, transcriptomics technologies allow scientists to study the complex interactions that enable life and cause disease, as well as assess the biological effects of therapeutics. Imaging-based spatial transcriptomics technologies are powerful methods to map the locations of hundreds to thousands of RNA transcripts within tissues to investigate the spatial organization of molecules and cells across tissues. "It's a completely new way of probing molecular interactions," said Hee-Sun Han (IGOH/GNDP), a professor of chemistry at the University of Illinois Urbana-Champaign. "Although we are getting a spatial map of molecules, like a really detailed Google Map, the community is not really clear on how to utilize the dataset. In this study, we utilize the co-localization pattern of molecules to identify potentially interacting molecular pairs and infer their functions. This is the beginning of our long journey to think about what information is embedded in this space." After connecting through the IGB's Gene Networks in Neural and Development Plasticity Research Theme, Han teamed up with Dave Zhao (GNDP), a professor of statistics at Illinois, and Saurabh Sinha, a former Illinois professor and current professor of biomedical engineering at the Georgia Institute of Technology. Using Han's knowledge of the technology and Sinha and Zhao's expertise in genomics analysis and statistics, they developed InSTAnT, an intracellular spatial transcriptomics toolkit. "I would say that the fundamental model of a cell can be thought of in terms of how its internal components are situated relative to each other, and not just how much of each there is. The toolkit allows you to break down these complicated biological systems into their smallest, most irreducible parts. Our new idea was to not so much look at where these smallest components are located, but instead how they are located with respect to each other," Zhao said. InSTAnT uses robust statistical tests and algorithms to identify proximal pairs—RNA transcripts located in close proximity. By finding these proximal pairs, InSTAnT offers new insights into sets of molecules that tend to work together, which can help scientists begin to understand their functions. "As an analogy, let's say we don't really know anything about how society functions. Who people interact with forms the basis of the function of the society. So, if we want to learn who is interacting with each other, what the functional units are, and what these units do, we can look at their relative location," Han said. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . Following this analogy, if one took photos of proximal pairs of people at different times of day, they could learn about their relationships and roles in society when analyzing the data. If people are located together during the day in Urbana, it could suggest that they are coworkers at Illinois. But if people tend to colocalize at night, it could indicate that they are roommates or family members. This is the basis of InSTAnT's technology. By looking at the simplest components of a complex system, one can begin to understand how complicated phenomena emerge. The InSTAnT toolkit also tests if a proximal pairs' sub-cellular colocalization shows any tissue-level spatial patterns, further adding to the benefits of using this technology. But while the underlying principles of identifying proximal pairs and searching for their colocalization patterns may sound simple, in practice InSTAnT is a highly complex statistical tool that was challenging to develop. "We drew inspiration from spatial statistics that have been developed for other contexts, such as ecology. While describing molecules inside a cell can be likened to describing trees in a region, there are unique differences such as the peculiarity and heterogeneity of cells that did not allow us to just use those statistics for the modeling," said Sinha, the lead researcher on the project. "So, we had to draw on completely different models, even non-spatial statistics, and combine these with spatial ideas to do the final modeling." Sinha credits Anurendra Kumar, a graduate student in his research group and first author of the paper, for driving this challenging project and bringing InSTAnT to life. Another key component of the InSTAnT toolkit is its accuracy and statistical rigor, especially when compared to existing tools. InSTAnT provides reproducible findings while maintaining a low rate of false positives when identifying proximal pairs. They accomplished this high robustness by leveraging team science. "One of the nice things about this team is that we were able to do both experimental and analytical work by collaborating. The Han group generated extra data in the lab so we could validate and test this tool. The ability to look at these robustness metrics, not just analytically or with simulated data, but also with real in vitro experimental data, is a big strength," Zhao said. The trio of professors acknowledged that the collective, collaborative efforts of their students was important to successfully pull off this multi-lab project. But as this chapter closes with the publication of the InSTAnT toolkit, this team's work is not done. Han said, "I got to know Saurabh and Dave through this collaboration, and we're developing new projects to tackle more grand challenge problems. This requires a multi-pronged approach that uses all of our different expertise. So to me, this is just the beginning of our exciting work together." More information: Anurendra Kumar et al, Intracellular spatial transcriptomic analysis toolkit (InSTAnT), Nature Communications (2024). DOI: 10.1038/s41467-024-49457-w Journal information: Nature Communications Provided by University of Illinois at Urbana-Champaign
Exotel’s FY24 loss narrows to a third, operating revenue up 6%Ransomware defenses are being weakened by outdated backup technology, limited backup data encryption, and failed data backups
Title: Clash Erupts as Male City Management Officer in Nanning Gets Slapped and Provoked by Onlooker
It is important to note that the situation in Syria is highly volatile and fluid, with multiple actors vying for power and influence. The actions of the Syrian opposition and the stance of Turkey are just two pieces of a much larger puzzle that includes regional powers, extremist groups, and international actors.Knight stops 20 shots, Florida rolls past Carolina 6-0 for 2nd win over 'Canes in as many days