wow88

wow88 Offering patients an injection is more effective than the current care of steroid tablets and cuts the need for further treatment by 30%, according to a study. Benralizumab is a monoclonal antibody that targets specific white blood cells, called eosinophils, to reduce lung inflammation. It is currently used as a repeat treatment for severe asthma at a low dose, but a new clinical trial has found that a higher single dose can be very effective if injected at the time of a flare-up. The findings, published in the Lancet Respiratory Medicine, included 158 people who needed medical attention in A&E for their asthma or COPD attack (COPD is a group of lung conditions that cause breathing difficulties). Patients were given a quick blood test to see what type of attack they were having, with those suffering an “eosinophilic exacerbation” involving eosinophils (a type of white blood cell) being suitable for treatment. Around 50% of asthma attacks are eosinophilic exacerbations, as are 30% of COPD ones, according to the scientists. The clinical trial, led by King’s College London and carried out at Oxford University Hospitals NHS Foundation Trust and Guy’s and St Thomas’ NHS Foundation Trust, saw patients randomly split into three groups. One group received the benralizumab injection and dummy tablets, another received standard care (prednisolone steroids 30mg daily for five days) and a dummy injection, and the third group received both the benralizumab injection and steroids. After 28 days, respiratory symptoms of cough, wheeze, breathlessness and sputum were found to be better in people on benralizumab. And after 90 days, there were four times fewer people in the benralizumab group who failed treatment compared with those receiving steroids. Treatment with the benralizumab injection also took longer to fail, meaning fewer visits to a GP or hospital for patients, researchers said. Furthermore, people also reported a better quality of life on the new regime. Scientists at King’s said steroids can have severe side-effects such as increasing the risk of diabetes and osteoporosis, meaning switching to benralizumab could provide huge benefits. Lead investigator Professor Mona Bafadhel, from King’s, said: “This could be a game-changer for people with asthma and COPD. “Treatment for asthma and COPD exacerbations have not changed in 50 years, despite causing 3.8 million deaths worldwide a year combined. “Benralizumab is a safe and effective drug already used to manage severe asthma. “We’ve used the drug in a different way – at the point of an exacerbation – to show that it’s more effective than steroid tablets, which is the only treatment currently available.” Researchers said benralizumab could also potentially be administered safely at home or in a GP practice, as well as in A&E. First author Dr Sanjay Ramakrishnan, clinical senior lecturer at the University of Western Australia, said: “Our study shows massive promise for asthma and COPD treatment. “COPD is the third leading cause of death worldwide but treatment for the condition is stuck in the 20th century. “We need to provide these patients with life-saving options before their time runs out.” Dr Samantha Walker, director of research and innovation at Asthma and Lung UK, welcomed the findings but said: “It’s appalling that this is the first new treatment for those suffering from asthma and COPD attacks in 50 years, indicating how desperately underfunded lung health research is.” AstraZeneca provided the drug for the study and funded the research, but had no input into trial design, delivery, analysis or interpretation.Notre Dame climbs to No. 3 in women's hoops poll

Brainrot, brat, extreme weather, midwest nice and weird round out the shortlist SAN MATEO, Calif. , Nov. 25, 2024 /PRNewswire/ -- Dictionary.com , the world's leading digital dictionary, today announced its 2024 Word of the Year: demure . Traditionally used to describe reserved or modest individuals, demure has taken on an expanded meaning this year to signify refined and sophisticated appearances or behaviors. "As remote work fades and in-person experiences become the norm again, the subtle art of personal presentation has taken on renewed importance," said Steve Johnson , Curriculum Design Manager of the Dictionary Media Group at IXL Learning . " Demure captures this cultural shift with a modern twist: a word that once carried traditional, often limiting connotations has been reimagined to celebrate understated elegance and suavity. Its evolving meaning gives people a way to express quiet confidence—embracing modesty and charm as intentional, empowering choices . " In making the annual selection, Dictionary.com 's lexicographers analyzed a wealth of data—including newsworthy headlines, search engine results and social media trends—to identify words that captured pivotal moments in 2024. The word demure dominated the cultural zeitgeist, with its usage in digital media surging a remarkable 1,200% between January and August. This meteoric rise is largely attributed to Jools Lebron, a content creator who popularized the phrase "very demure, very mindful" in a series of TikTok videos illustrating how to embody the term in professional, travel and social settings. The social media buzz surrounding demure sparked a similar spike in search interest. In the 11 months before Lebron's videos, there was no notable trend in Google searches for the term, but interest surged 14-fold by August 2024 . At its peak, searches for demure on Dictionary.com were 200 times greater than their previous rate. While the initial trend has cooled, the word remains five times more popular on Dictionary.com than it was before its breakout moment. Alongside demure, Dictionary.com 's lexicographers identified five additional words that shaped the cultural conversation in 2024, rounding out this year's shortlist. Read more about Dictionary.com 's 2024 Word of the Year at http://dictionary.com/e/word-of-the-year/ . About Dictionary.com Words define every aspect of our lives, from our ideas to our identities. Dictionary.com aspires to empower people to express themselves, make connections and find opportunities through the power and joy of language. With 96 million visitors each month, Dictionary.com is the premier destination to learn, discover and have fun with the limitless world of words and meanings. The brand helps you make sense of the ever-evolving English language so you can put your ideas into words—and your words into action. Press Contact Joslyn Chesson IXL Learning press@ixl.com View original content to download multimedia: https://www.prnewswire.com/news-releases/dictionarycom-names-demure-as-the-2024-word-of-the-year-302315735.html SOURCE IXL LearningPakistan in contact with Musk's Starlink for 'uninterrupted' internet servicesSemona scores 15 as Stonehill takes down Lafayette 70-65

The AP Top 25 men’s college basketball poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . COLORADO SPRINGS, Colo. (AP) — EJ Neal had 12 points in Sacramento State’s 63-61 win against Air Force on Wednesday night. Neal had five rebounds for the Hornets (2-4). Julian Vaughns shot 5 for 8, including 2 for 4 from beyond the arc to add 12 points. Jacob Holt had 10 points and shot 3 of 5 from the field and 4 of 4 from the free-throw line. The Falcons (2-5) were led by Jeffrey Mills, who posted 19 points. Ethan Taylor added 11 points, eight rebounds, five assists and two steals for Air Force. Vaughns scored eight points in the first half and Sacramento State went into halftime trailing 33-22. Sacramento State used a 12-0 second-half run to take the lead at 34-33. Lachlan Brewer scored 10 second-half points. ___ The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Astera Labs CFO sells $36.1 million in stock

NoneNoneThe Nov. 25 meeting of the Paris Select Board is featured on Norway Paris Community Television’s website. The board has agreed to enlist Casco Bay Advisors LLC to help renegotiate the town’s franchise agreement with cable companies. Screenshot PARIS — Paris will enlist Casco Bay Advisors LLC in updating the town’s franchise agreement with cable companies at the suggestion of the Norway Paris Community Television Board. The renegotiation of this agreement will allow the public access station and the town to continue collecting franchise fees on cable subscriptions as well as video streaming, or video service provider, subscriptions, in addition to being able to keep up with high definition transmission and other technology, Station Manager Peter Morton told the select board Nov. 25. L.D. 1967, “An Act to Support Municipal Franchise Agreements,” went into effect in August and the towns will only be able to collect franchise fees from the video service providers, or streaming boxes, that are being increasingly offered by cable companies like Spectrum and Charter Communications, if the agreements are modified. “I believe this is meant to subvert the franchise fees and phase out cable access channels in general,” Morton said of the cable companies’ push towards online video streaming boxes which operate on Wi-Fi rather than traditional cable boxes that are hardwired by coaxial cable in a residence. “Franchise agreements are an agreement that is mandated by federal law if any company utilizes the public right of way, so think of the poles and wires owned by a town, they have to get a franchise agreement with the town,” Melanie Sachs, a Maine House representative and original sponsor of the bill, told the WABI 5 news station in Bangor in January. The Federal Cable Act of 1984 gave municipalities an option to charge cable companies a fee for services. Sachs says there hasn’t been any enforcement of those franchise agreements at a state level. Norway Paris Community Television is an “independent, 501 (c)3 non-profit corporation. Our mission is to strengthen the fabric of community life by providing communication tools, training and opportunities for individuals, nonprofit groups, governments and educational institutions,” its website reads. The last franchise agreement with the cable companies was updated in 2004 and has been grandfathered since then. Morton says that Casco Bay Advisors LLC is the right company to modify the agreement and the Norway PAris Community Television Board has agreed to fund the cost, which will land somewhere in the $2,500 to $5,000 range. “Sounds like a no-brainer,” Select Board member Chris Williams said. The Paris Select Board will next meet at the town office at 6 p.m. Dec. 9. We invite you to add your comments. We encourage a thoughtful exchange of ideas and information on this website. By joining the conversation, you are agreeing to our commenting policy and terms of use . More information is found on our FAQs . You can modify your screen name here . Comments are managed by our staff during regular business hours Monday through Friday as well as limited hours on Saturday and Sunday. Comments held for moderation outside of those hours may take longer to approve. Please sign into your Sun Journal account to participate in conversations below. If you do not have an account, you can register or subscribe . Questions? Please see our FAQs . Your commenting screen name has been updated. Send questions/comments to the editors. « Previous Next »Police hunt for UnitedHealthcare CEO's masked killer after 'brazen, targeted' attack on NYC street

Texans remember Jimmy Carter, the last Democrat to take the state’s presidential election(BPT) - The holidays bring a whirlwind of excitement, sales, and unfortunately also scams. Black Friday, Small Business Saturday, and Cyber Week mean increased online transactions, e-commerce traffic, and a heightened focus on fulfilling customer orders — all of which make small businesses, especially micro-businesses, prime targets for cybercriminals. According to Bank of America's Small Business Owner's Report , more than half of small business owners said cybersecurity threats have impacted their business. Unlike larger corporations with dedicated IT departments, many small and micro businesses lack proper security infrastructure, leaving them more vulnerable to and harmed by threats. A single scam or breach can be costly and can put a business behind during the busy holiday season. Scammers know how to exploit the season's hustle and bustle. But don't let the Grinch steal your seasonal success — arm yourself with these tips from the pros at Norton Small Business to stay protected and keep the holiday cheer intact. The Naughty List: Common Holiday Cyber Scams In today's digital-first world, cybersecurity is no longer optional — it's a necessity. With cyber threats evolving constantly, safeguarding your business requires vigilance, informed employees, and robust practices. Investing in cybersecurity tools is a simple way to address these concerns. The Nice List: 7 Cyber Safety Tips for the Holidays In a world where scams are harder to detect it is good to have extra help. Owners and employees can check in real time if something might be a scam with the free Norton Genie app . With a simple screen shot, this AI-powered scam detection tool can tell you if a text message, social media post, email or website message is likely to be a scam, what makes the content suspicious, and what to do next. Beyond just protecting your systems, it's essential to build trust with your customers by showing them that your business takes cybersecurity seriously. Displaying security badges on your website, being transparent about how customer data is protected, and offering secure payment options can go a long way in fostering customer confidence and retention. The holidays are a time of opportunity for both small businesses and scammers. By adopting these best practices, you can protect your business, your customers, and your peace of mind this season. Think of Norton Small Business as your holiday helper, protecting your devices and data while you focus on operating your business. With easy setup and robust features, it's your always-on IT department working 24/7 to protect your business and employees. Visit https://us.norton.com/products/small-business for more information.

Aston Villa’s disallowed goal would have counted in England – Unai EmeryBrainrot, brat, extreme weather, midwest nice and weird round out the shortlist SAN MATEO, Calif. , Nov. 25, 2024 /PRNewswire/ -- Dictionary.com , the world's leading digital dictionary, today announced its 2024 Word of the Year: demure . Traditionally used to describe reserved or modest individuals, demure has taken on an expanded meaning this year to signify refined and sophisticated appearances or behaviors. "As remote work fades and in-person experiences become the norm again, the subtle art of personal presentation has taken on renewed importance," said Steve Johnson , Curriculum Design Manager of the Dictionary Media Group at IXL Learning . " Demure captures this cultural shift with a modern twist: a word that once carried traditional, often limiting connotations has been reimagined to celebrate understated elegance and suavity. Its evolving meaning gives people a way to express quiet confidence—embracing modesty and charm as intentional, empowering choices . " In making the annual selection, Dictionary.com 's lexicographers analyzed a wealth of data—including newsworthy headlines, search engine results and social media trends—to identify words that captured pivotal moments in 2024. The word demure dominated the cultural zeitgeist, with its usage in digital media surging a remarkable 1,200% between January and August. This meteoric rise is largely attributed to Jools Lebron, a content creator who popularized the phrase "very demure, very mindful" in a series of TikTok videos illustrating how to embody the term in professional, travel and social settings. The social media buzz surrounding demure sparked a similar spike in search interest. In the 11 months before Lebron's videos, there was no notable trend in Google searches for the term, but interest surged 14-fold by August 2024 . At its peak, searches for demure on Dictionary.com were 200 times greater than their previous rate. While the initial trend has cooled, the word remains five times more popular on Dictionary.com than it was before its breakout moment. Alongside demure, Dictionary.com 's lexicographers identified five additional words that shaped the cultural conversation in 2024, rounding out this year's shortlist. Read more about Dictionary.com 's 2024 Word of the Year at http://dictionary.com/e/word-of-the-year/ . About Dictionary.com Words define every aspect of our lives, from our ideas to our identities. Dictionary.com aspires to empower people to express themselves, make connections and find opportunities through the power and joy of language. With 96 million visitors each month, Dictionary.com is the premier destination to learn, discover and have fun with the limitless world of words and meanings. The brand helps you make sense of the ever-evolving English language so you can put your ideas into words—and your words into action. Press Contact Joslyn Chesson IXL Learning press@ixl.com View original content to download multimedia: https://www.prnewswire.com/news-releases/dictionarycom-names-demure-as-the-2024-word-of-the-year-302315735.html SOURCE IXL Learning

Tweet Facebook Mail A US judge will decide today whether new evidence warrants a re-examination of the convictions of Erik and Lyle Menendez in the shotgun murders of their parents in their Beverly Hills home more than 30 years ago. The brothers were found guilty of murdering Jose and Kitty Menendez in 1989 and sentenced to life in prison without parole. While their defence attorneys argued at trial that they had been sexually abused by their father, prosecutors denied that and accused them of killing their parents for money. In the years that followed, they repeatedly appealed their convictions without success. READ MORE: Tourist yacht sinks in high waves, 17 people missing  Erik Menendez, left, and Lyle Menendez. (AP) Now, at 53 and 56, Erik and Lyle Menendez are making a new bid for freedom. Their lawyers filed a habeas corpus petition — a request for a court to examine whether someone is being lawfully detained — in May 2023, asking a judge to consider new evidence of their father's sexual abuse. "Newly discovered evidence directly supports the defense presented at trial," the petition said. The recent releases of the Netflix drama Monsters: Lyle and Erik Menendez Story and the documentary The Menendez Brothers in 2024 brought renewed public attention to their plight. Members of the public will be given the opportunity to win a seat in the courtroom to catch a glimpse of the brothers, who will be appearing virtually. READ MORE: Million-selling novelist Barbara Taylor Bradford dies at 91  Lyle, left, and Erik Menendez with defence attorney Leslie Abramson, right, in court in 1990. (AP) Prosecutors recommended resentencing for the brothers last month, saying they have worked on redemption and rehabilitation and demonstrated good behaviour inside prison. Los Angeles District Attorney George Gascón held a news conference less than two weeks before Election Day, asking for new sentences of 50 years to life. This could make them immediately eligible for parole because they were less than 26 years old when they killed their parents. The brothers' extended family has pleaded for their release, saying they deserve to be free after decades behind bars. READ MORE: DNA confirms man who had passed polygraph test as suspected killer in cold case  New evidence could see the brothers set free. (AP) Several family members have said that in today's world — which is more aware of the impact of sexual abuse — the brothers would not have been convicted of first-degree murder and sentenced to life. Not all Menendez family members support resentencing. Attorneys for Milton Andersen, the 90-year-old brother of Kitty Menendez, filed a legal brief asking the court to keep the brothers' original punishment. "They shot their mother, Kitty, reloading to ensure her death," Andersen's attorneys said in a statement last week. "The evidence remains overwhelmingly clear: the jury's verdict was just, and the punishment fits the heinous crime." Superior Court Judge Michael Jesic is scheduled to consider the resentencing request on December 11, but on Monday, he'll first address the abuse evidence raised in the habeas petition. Immediate freedom is one possible result; the judge also might weigh in on the merits of the evidence. And if the brothers don't get relief in court, they can hope California's governor will grant them clemency. The new evidence includes a letter Erik Menendez wrote in 1988 to his uncle Andy Cano, describing the sexual abuse he had endured from his father. The brothers asked their lawyers about it after it was mentioned in a 2015 Barbara Walters television special. The lawyers hadn't known of the letter and realised it had not been introduced at their trials, making it effectively new evidence that they say corroborates allegations that Erik was sexually abused by his father. More new evidence emerged when Roy Rossello, a former member of the Latin pop group Menudo, recently came forward saying he had been drugged and raped by Jose Menendez, the boys' father, when he was a teen in the 1980s. Menudo was signed under RCA Records, where Jose Menendez was chief operating officer. Rossello spoke about his abuse in the Peacock docuseries Menendez + Menudo: Boys Betrayed , and provided a signed declaration to the brothers' lawyers. Had these two pieces of evidence been available during the brothers' trial, prosecutors would not have been able to argue that there was no corroboration of sexual abuse, or that their father Jose Menendez was not the "kind of man that would" abuse children, the petition argues. While clemency might be another pathway to freedom for the brothers, California Governor Gavin Newsom said last week that he won't decide until incoming Los Angeles district attorney Nathan Hochman reviews the case. Hochman, a Republican-turned-Independent who unseated the progressive Gascón on December 2, has said he wants to carefully look at the evidence before making any decisions. DOWNLOAD THE 9NEWS APP : Stay across all the latest in breaking news, sport, politics and the weather via our news app and get notifications sent straight to your smartphone. Available on the Apple App Store and Google Play .

BTTR Stock Alert: Halper Sadeh LLC is Investigating Whether the Merger of Better Choice Company Inc. is Fair to ShareholdersPeeling Back The Layers: Exploring National Bank Holdings Through Analyst Insights