
Nelistotug is under clinical development by and currently in Phase II for Recurrent Head And Neck Squamous Cell Carcinoma. According to GlobalData, Phase II drugs for Recurrent Head And Neck Squamous Cell Carcinoma have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Nelistotug overview GSK overview is a healthcare company that focuses on developing, manufacturing and commercializing general medicines, specialty medicines and vaccines. It offers drugs for the treatment of diseases such as HIV, respiratory, cancer, immuno-inflammation, anti-viral, central nervous system (CNS), metabolic, cardiovascular, and urogenital, anti-bacterial, dermatology and rare diseases. The company also offers over-the-counter (OTC) products for pain relief, oral health, nutrition, skin health and gastrointestinal diseases. ’s vaccine portfolio covers various diseases including hepatitis, diphtheria, tetanus, whooping cough, rotavirus and HPV infections, measles and bacterial meningitis, among others. The company sells its products through wholesalers, pharmacies, hospitals, physicians and other groups worldwide. is headquartered in London, England, the UK. For a complete picture of Nelistotug’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .TORONTO — The Grey Cup-champion Toronto Argonauts signed American running back Kevin Brown on Friday. The five-foot-nine, 205-pound Brown rushed for 522 yards on 101 carries in 12 games last season with the Edmonton Elks. He added 22 catches for 138 yards before finishing the '24 campaign on the CFL club's practice roster. In 2023, Brown ran for 1,141 yards and four TDs with Edmonton. He also had 28 receptions for 222 yards and a touchdown. Brown, 28, spent three seasons with the Elks, running for 2,149 yards (six-yard average) and five TDs. He added 74 catches for 536 yards and a touchdown in 37 regular-season games. This report by The Canadian Press was first published Dec. 13, 2024. The Canadian PressWASHINGTON (Reuters) - U.S. President-elect Donald Trump said the extension of the debt ceiling will "go down as one of the dumbest political decisions made in years," referring to a 2023 budget deal struck by then-House Speaker Kevin McCarthy and President Joe Biden. Under that deal, Congress suspended the debt ceiling until Jan. 1, 2025. The U.S. Treasury will be able to pay its bills for several more months, but Congress will have to address the issue at some point next year. In a post on Truth Social, Trump said, "The extension of the Debt Ceiling by a previous Speaker of the House, a good man and a friend of mine ... will go down as one of the dumbest political decisions made in years." He added, "The Democrats must be forced to take a vote on this treacherous issue NOW, during the Biden Administration, and not in June. They should be blamed for this potential disaster, not the Republicans!" (Reporting by Jasper Ward; Editing by Don Durfee)
Google's search business is all about distribution. The DOJ wants to take this away, and it's freaking investors out.OpenAI restructures to public benefit corporation, aims to raise capital
Dalyn Wakely scores pair to lead Colts to 3-1 victory over BattalionSeven Tulsa-area lawmakers showed up Friday to answer local education leaders’ questions about State Superintendent Ryan Walters’ political rhetoric, accountability for private school tax credits and who should decide whether schools should be allowed four-day work weeks. Ahead of the start of the next session of the Oklahoma Legislature on Feb. 3, Jenks Public Schools hosted its 32nd annual legislative luncheon at Jenks High School. In attendance were Tulsa Democrats Rep. Amanda Swope and Rep. Suzanne Schreiber, and Republicans Rep. Mark Tedford, Tulsa; Rep. Mike Lay, Jenks; Rep. Rob Hall, Tulsa; Sen. Aaron Reinhardt, Jenks; and Sen. Brian Guthrie, Bixby. Right out of the gates, local education leaders wanted to know what, if anything, local lawmakers could do about Walters’ repeated claims that public schools in Oklahoma need to be rid of woke, liberal indoctrinators. People are also reading... 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Meet the 2024 Tulsans of the Year: These people worked hard to make Tulsa better Four-day school week discussion: BA school officials release feasibility study findings Bill Haisten: There still is no resolution, but a Gundy-OSU divorce seems imminent OSSAA board votes unanimously to deny hardship waiver of East Central basketball player Bill Haisten: Union's search heats up, and Owasso’s Antonio Graham has Union ties Antonio Graham leaves Owasso for a ‘dream come true’ situation at Union Berry Tramel: Jackson Arnold shows OU should save its high-end shopping for the portal Broken Arrow Public Schools releases calendar options for four-day week Final OU football bowl projections before Sooners' postseason destination is revealed Cooper Parker secures Bixby's seventh consecutive state title in OT thriller versus Owasso Assessing OU football's top transfer portal needs: Heavy on offense, but a little defense, too POLL CLOSED: Vote for the Bill Knight Automotive high school football player of the week for Week 14 Court 'bulldozes' tribal law in Tulsa case over jurisdiction, attorney says Berry Tramel: OU's victory over Alabama comes at quite the cost, courtesy of the playoff Tedford said he has maintained what he believes is a “pretty good relationship” Walters, and he has advised him to focus on “classroom performance issues and less about social agenda issues.” “From my perspective, there’s only so much of that advice that he’ll be willing to take,” Tedford said, before adding that he is a proponent of creating a plan to continually raise teacher pay, possibly tied to cost of living. Schreiber encouraged educators and others concerned about negative perceptions about teachers to challenge lawmakers to visit local public school classrooms. “Ask them: 'Have you met a teacher?’ Get legislators into your buildings, ... make them remember what is happening in a public school every day,” Schreiber said. “When you get a policymaker in a classroom — help them remember what’s going on, and all of those proximate agendas go away.” Reinhardt, a freshman lawmaker, said he shares education leaders’ concern about the impact negative rhetoric is having on the recruitment and retention of teachers amid historic shortfalls in Oklahoma’s applicant pool. “It is extremely difficult. It’s hurtful. It’s making the jobs of all of these people more difficult,” Reinhardt said. “Certain individuals may continue on however they decide to handle themselves. There are some things we can do to protect teachers — maybe through due process ... to make sure teachers’ rights are being protected.” The panel of lawmakers was asked how they plan to hold private schools that ultimately receive taxpayer-funds through Oklahoma Parental Choice Tax Credits to the same standards as public schools. Schreiber said it is clear after the first year of the program that many of the tax credits are going to families who already paid for their children to attend private schools, rather than the program’s stated intent of opening new pathways to school choice for families who couldn’t afford private school tuition. “You should be able to see what those dollars pay for and what those outcomes are, and right now, with our taxpayer credits, we don’t have that kind of transparency,” she said. Swope, who is set to resign as a House representative because she just accepted a new job in the administration of newly elected Tulsa Mayor Monroe Nichols, said she believes tax credit recipients and the private schools where they use those taxpayer funds should expect accountability. “There is no such thing as free money — there is always going to be some kind of accountability that comes with it. I think the reality is that means that the state should have the ability to talk about admission to those institutions, curriculum and standards and testing that are in place for that,” Swope said. “If you don’t want to be susceptible for the public standard, then don’t open yourself up to public money.” About whether the state should take back control from local school boards over four-day school weeks, Reinhardt spoke out to say it should remain a matter of local control and he personally understands why the idea is being discussed in more districts. "The biggest takeaway from public education right now is our teacher shortage. There's no getting around it," Reinhardt said. "Schools are being forced to get creative to attract and keep teachers, and one of those is a shorter work week. You see it in every industry. "My industry, the insurance world, it's a hybrid work week. If you don't have some sort of hybrid work week, good luck keeping employees. Well, that's what schools are facing right now. Those are tough decisions." Tulsa World is where your story lives
BATHINDA: Apprehending possible attempts by Punjab government to 'forcibly' provide medical aid to fasting farmer leader Jagjit Singh Dallewal following the tough stance taken by SC, protesting farmers Sunday stepped up security at the protest site in Khanauri in Punjab. Dallewal's fast-unto-death entered the 34th day Sunday, with his health condition slipping every day, according to doctors. It is learnt that a three-ring security is in place, with stick-carrying volunteers on guard round-the-clock. The volunteers check every vehicle coming to the protest site, note down the registration number, and check identity of those in the vehicle. The tractor-trailers around Dallewal's chamber have been welded together to prevent any vehicles from approaching it. SC had Saturday asked Punjab government to file an affidavit outlining the compliance on providing medical aid to Dallewal. The court will take up the matter on December 31. Farmers maintain that the court has taken a strict view on medical aid to Dallewal, but the letters written by Dallewal to the President, PM, and CJI have been ignored. Farmer Abhimanyu Kohad said their protest is based on non-violent principles, and going by it, Dallewal is facing hardships on his body. He urged SC not to give such hard directions and pointed out that in the event of something government untoward happening, Centre and constitutional institutions will also be held responsible. In a bid to prevail upon Dallewal to accept medical aid and to assess the situation, retired ADGP Jaskaran Singh, retired DIG Narinder Bhargav, Patiala Range DIG Mandeep Singh Sidhu, and Patiala SSP Nanak Singh held a meeting with farmers at Khanauri. Amid this, the farmers Sunday readied for December 30 Punjab bandh. SKM (non-political) and Kisan Mazdoor Morcha called for Punjab bandh and claimed their strike call has received strong support from transporters, employees, traders, and other sections of society including religious bodies. The outfits have called for disruption of rail and road traffic from 7am to 4pm and a complete shutdown, with no supply of even milk and vegetables. Emergency services have, however, been exempted.Broncos hope to continue playoff push when they meet the banged-up Raiders
The same old tune in a different key is playing once again for Joel Embiid . The Philadelphia 76ers announced on Friday that their star center Embiid is questionable to play vs. the Utah Jazz on Saturday due to a left foot sprain and a sinus fracture. Embiid has already been playing through the sinus fracture, which he suffered on a freak play against Indiana two weeks ago . But the left foot sprain is a brand-new issue for him. It appears that Embiid sustained the foot sprain on a layup attempt in the closing minutes of Philly’s Christmas Day win over the Boston Celtics. Such a huge play for so many reasons: -Sixers needed a stabilizing possession. Maxey-Embiid two-man game delivered -Embiid set a good screen, rolled(!) and got to the rim vs. Horford, drawing a foul. Set up a big Maxey layup later -Embiid came up gimpy but finished the game pic.twitter.com/SG38G322OH — Paul Hudrick (@PaulHudrick) December 26, 2024 The former MVP Embiid has played in just nine of the 76ers’ 28 games so far this season due to a nagging issue with his left knee, which he underwent meniscus surgery on in February of this year. Embiid also suffered a strange injury to his right ankle in pregame warmups for the Celtics game on Christmas ( video here ) but managed to play through that issue. A new foot sprain on top of that is obviously a big concern for Embiid, who is listed at seven feet and 280 pounds. It is to the same leg that cost Embiid most of this season already, and now the 11-17 76ers may have to brace themselves for more time without their seven-time All-Star center. This article first appeared on Larry Brown Sports and was syndicated with permission.ATLANTA (AP) — Jimmy Carter, the peanut farmer who tried to restore virtue to the White House after the Watergate scandal and Vietnam War, then rebounded from a landslide defeat to become a global advocate of human rights and democracy, has died. He was 100 years old . The Carter Center said the 39th president died Sunday afternoon, more than a year after entering hospice care , at his home in Plains, Georgia, where he and his wife, Rosalynn, who died in November 2023, lived most of their lives. The center said he died peacefully, surrounded by his family. As reaction poured in from around the world, President Joe Biden mourned Carter’s death, saying the world lost an “extraordinary leader, statesman and humanitarian” and he lost a dear friend. Biden cited Carter’s compassion and moral clarity, his work to eradicate disease, forge peace, advance civil and human rights, promote free and fair elections, house the homeless and advocacy for the disadvantaged as an example for others. “To all of the young people in this nation and for anyone in search of what it means to live a life of purpose and meaning – the good life – study Jimmy Carter, a man of principle, faith, and humility,” Biden said in a statement. “He showed that we are a great nation because we are a good people – decent and honorable, courageous and compassionate, humble and strong.” Biden said he is ordering a state funeral for Carter in Washington. A moderate Democrat, Carter ran for president in 1976 as a little-known Georgia governor with a broad grin, effusive Baptist faith and technocratic plans for efficient government. His promise to never deceive the American people resonated after Richard Nixon’s disgrace and U.S. defeat in southeast Asia. “If I ever lie to you, if I ever make a misleading statement, don’t vote for me. I would not deserve to be your president,” Carter said. Carter’s victory over Republican Gerald Ford, whose fortunes fell after pardoning Nixon, came amid Cold War pressures, turbulent oil markets and social upheaval over race, women’s rights and America’s role in the world. His achievements included brokering Mideast peace by keeping Egyptian President Anwar Sadat and Israeli Prime Minister Menachem Begin at Camp David for 13 days in 1978. But his coalition splintered under double-digit inflation and the 444-day hostage crisis in Iran. His negotiations ultimately brought all the hostages home alive, but in a final insult, Iran didn’t release them until the inauguration of Ronald Reagan, who had trounced him in the 1980 election. Humbled and back home in Georgia, Carter said his faith demanded that he keep doing whatever he could, for as long as he could, to try to make a difference. He and Rosalynn co-founded The Carter Center in 1982 and spent the next 40 years traveling the world as peacemakers, human rights advocates and champions of democracy and public health. Awarded the Nobel Peace Prize in 2002, Carter helped ease nuclear tensions in North and South Korea, avert a U.S. invasion of Haiti and negotiate cease-fires in Bosnia and Sudan. By 2022, the center had monitored at least 113 elections around the world. Carter was determined to eradicate guinea worm infections as one of many health initiatives. Swinging hammers into their 90s, the Carters built homes with Habitat for Humanity. The common observation that he was better as an ex-president rankled Carter. His allies were pleased that he lived long enough to see biographers and historians revisit his presidency and declare it more impactful than many understood at the time. Propelled in 1976 by voters in Iowa and then across the South, Carter ran a no-frills campaign. Americans were captivated by the earnest engineer, and while an election-year Playboy interview drew snickers when he said he “had looked on many women with lust. I’ve committed adultery in my heart many times,” voters tired of political cynicism found it endearing. The first family set an informal tone in the White House, carrying their own luggage, trying to silence the Marine Band’s traditional “Hail to the Chief" and enrolling daughter, Amy, in public schools. Carter was lampooned for wearing a cardigan and urging Americans to turn down their thermostats. But Carter set the stage for an economic revival and sharply reduced America's dependence on foreign oil by deregulating the energy industry along with airlines, trains and trucking. He established the departments of Energy and Education, appointed record numbers of women and nonwhites to federal posts, preserved millions of acres of Alaskan wilderness and pardoned most Vietnam draft evaders. Emphasizing human rights , he ended most support for military dictators and took on bribery by multinational corporations by signing the Foreign Corrupt Practices Act. He persuaded the Senate to ratify the Panama Canal treaties and normalized relations with China, an outgrowth of Nixon’s outreach to Beijing. But crippling turns in foreign affairs took their toll. When OPEC hiked crude prices, making drivers line up for gasoline as inflation spiked to 11%, Carter tried to encourage Americans to overcome “a crisis of confidence.” Many voters lost confidence in Carter instead after the infamous address that media dubbed his “malaise" speech, even though he never used that word. After Carter reluctantly agreed to admit the exiled Shah of Iran to the U.S. for medical treatment, the American Embassy in Tehran was overrun in 1979. Negotiations to quickly free the hostages broke down, and then eight Americans died when a top-secret military rescue attempt failed. Carter also had to reverse course on the SALT II nuclear arms treaty after the Soviets invaded Afghanistan in 1979. Though historians would later credit Carter's diplomatic efforts for hastening the end of the Cold war, Republicans labeled his soft power weak. Reagan’s “make America great again” appeals resonated, and he beat Carter in all but six states. Born Oct. 1, 1924, James Earl Carter Jr. married fellow Plains native Rosalynn Smith in 1946, the year he graduated from the Naval Academy. He brought his young family back to Plains after his father died, abandoning his Navy career, and they soon turned their ambitions to politics . Carter reached the state Senate in 1962. After rural white and Black voters elected him governor in 1970, he drew national attention by declaring that “the time for racial discrimination is over.” Carter published more than 30 books and remained influential as his center turned its democracy advocacy onto U.S. politics, monitoring an audit of Georgia’s 2020 presidential election results. After a 2015 cancer diagnosis, Carter said he felt “perfectly at ease with whatever comes.” “I’ve had a wonderful life,” he said. “I’ve had thousands of friends, I’ve had an exciting, adventurous and gratifying existence.” Sanz is a former Associated Press reporter.