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Dazostinag sodium is under clinical development by and currently in Phase I for Triple-Negative Breast Cancer (TNBC). According to GlobalData, Phase I drugs for Triple-Negative Breast Cancer (TNBC) have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Dazostinag sodium overview Dazostinag sodium (TAK-676) is under development for the treatment of advanced or metastatic solid tumors including non-small cell lung cancer, triple-negative breast cancer (TNBC), oropharyngeal cancer, colorectal cancer and head and neck cancer squamous cell carcinoma. The drug candidate is cyclic purine dinucleotide and acts by targeting stimulator of interferon genes (STING/TMEM173). It is a new molecular entity. It is administered via intravenous route. Takeda Pharmaceutical overview (Takeda) is a global pharmaceutical company primarily engaged in the research, development, production, and commercialization of biopharmaceutical products. It provides treatment for inflammatory bowel disease, acid-related diseases, motility disorders and liver diseases; hemophilia and hereditary bleeding disorders; primary immunodeficiency and multifocal motor neuropathy; major depressive disorder and attention-deficit hyperactivity disorder; and its cancer treatment encompasses multiple myeloma, mantle cell lymphoma, non-small cell lung cancer and chronic myeloid leukemia. While the company markets its pharmaceutical products directly, it also collaborates with marketing alliance partners in worldwide. Takeda operates in various countries worldwide, including Japan, the US, Europe, Latin America, Africa, the Middle East, and the Asia Pacific region. Takeda is headquartered in Tokyo, Japan. For a complete picture of Dazostinag sodium’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
BEIRUT — Israel's military launched airstrikes across Lebanon on Monday, unleashing explosions throughout the country and killing at least 31 while Israeli leaders appeared to be closing in on a negotiated ceasefire with the Hezbollah militant group. Israeli strikes hit commercial and residential buildings in Beirut as well as in the port city of Tyre. Military officials claimed they targeted areas known as Hezbollah strongholds. They issued evacuation orders for Beirut's southern suburbs, and strikes landed across the city, including meters from a Lebanese police base and the city's largest public park. The barrage came as officials indicated they were nearing agreement on a ceasefire, while Israeli Prime Minister Benjamin Netanyahu's Security Cabinet prepared to discuss an offer on the table. Bulldozers remove the rubble of a destroyed building Monday that was hit in an Israeli airstrike in Dahiyeh, in the southern suburb of Beirut, Lebanon. Foreign ministers from the world’s leading industrialized nations also expressed cautious optimism Monday about possible progress on a ceasefire. “Knock on wood,” Italian Foreign Minister Antonio Tajani said as he opened the Group of Seven meeting outside Rome. “We are perhaps close to a ceasefire in Lebanon," he said. "Let's hope it's true and that there's no backing down at the last-minute.” A ceasefire in Gaza and Lebanon was foremost on the agenda of the G7 meeting in Fiuggi, outside Rome, that gathered ministers from Canada, France, Germany, Italy, Japan, the United Kingdom and the United States, in the last G7 encounter of the Biden administration. For the first time, the G7 ministers were joined by their counterparts from Saudi Arabia, Egypt, Jordan, the United Arab Emirates and Qatar, as well as the Secretary General of the Arab League. Thick smoke, flames and debris erupt Monday from an Israeli airstrike that targeted a building in Tayouneh, Beirut, Lebanon. Meanwhile, massive explosions lit up Lebanon's skies with flashes of orange, sending towering plumes of smoke into the air as Israeli airstrikes pounded Beirut's southern suburbs Monday. The blasts damaged buildings and left shattered glass and debris scattered across nearby streets. Some of the strikes landed close to central Beirut and near Christian neighborhoods and other targets where Israel issued evacuation warnings, including in Tyre and Nabatiyeh province. Israeli airstrikes also hit the northeast Baalbek-Hermel region without warning. Lebanon's Health Ministry said Monday that 26 people were killed in southern Lebanon, four in the eastern Baalbek-Hermel province and one in Choueifat, a neighborhood in Beirut's southern suburbs that was not subjected to evacuation warnings on Monday. The deaths brought the total toll to 3,768 killed in Lebanon throughout 13 months of war between Israel and Hezbollah and nearly two months since Israel launched its ground invasion. Many of those killed since the start of the war between Israel and Hezbollah have been civilians, and health officials said some of the recovered bodies were so severely damaged that DNA testing would be required to confirm their identities. Israel claims to have killed more than 2,000 Hezbollah members. Lebanon's Health Ministry says the war has displaced 1.2 million people. Destroyed buildings stand Monday in the area of a village in southern Lebanon as seen from northern Israel. Israeli ground forces invaded southern Lebanon in early October, meeting heavy resistance in a narrow strip of land along the border. The military previously exchanged attacks across the border with Hezbollah, an Iran-backed militant group that began firing rockets into Israel the day after the war in Gaza began last year. Lebanese politicians have decried the ongoing airstrikes and said they are impeding ceasefire negotiations. The country's deputy parliament speaker accused Israel of ramping up its bombardment to pressure Lebanon to make concessions in indirect ceasefire negotiations with Hezbollah. Elias Bousaab, an ally of the militant group, said Monday that the pressure has increased because "we are close to the hour that is decisive regarding reaching a ceasefire." Israeli officials voiced similar optimism Monday about prospects for a ceasefire. Mike Herzog, the country's ambassador to Washington, earlier in the day told Israeli Army Radio that several points had yet to be finalized. Though any deal would require agreement from the government, Herzog said Israel and Hezbollah were "close to a deal." "It can happen within days," he said. Israeli officials have said the sides are close to an agreement that would include withdrawal of Israeli forces from southern Lebanon and a pullback of Hezbollah fighters from the Israeli border. But several sticking points remain. A member of the Israeli security forces inspects an impact site Sunday after a rocket fired from Lebanon hit an area in Rinatya, outskirts of Tel Aviv, Israel. After previous hopes for a ceasefire were dashed, U.S. officials cautioned that negotiations were not yet complete and noted that there could be last-minute hitches that either delay or destroy an agreement. "Nothing is done until everything is done," White House national security spokesman John Kirby said Monday. The proposal under discussion to end the fighting calls for an initial two-month ceasefire during which Israeli forces would withdraw from Lebanon and Hezbollah would end its armed presence along the southern border south of the Litani River. The withdrawals would be accompanied by an influx of thousands more Lebanese army troops, who have been largely sidelined in the war, to patrol the border area along with an existing U.N. peacekeeping force. Western diplomats and Israeli officials said Israel demands the right to strike in Lebanon if it believes Hezbollah is violating the terms. The Lebanese government says such an arrangement would authorize violations of the country's sovereignty. On paper, being more sustainable and eco-friendly while shopping sounds great—so why don't more people do it? There is growing consumer consciousness about the environmental impact of where people choose to shop and the sustainability of the products they buy. According to McKinsey, over 60% of individuals surveyed in 2020 said they would be willing to pay more for a product that is packaged in an eco-friendly way. Since 2019, products marketed as being environmentally sustainable have seen a 28% growth in revenue compared to 20% for products with no such marketing, a 2023 McKinsey and NielsenIQ report found. Much of this is thanks to the preferences and attitudes of Gen Z, who, on average, care more than their older counterparts about being informed shoppers. The younger generation also has more social justice and environmental awareness altogether. Shoppers are willing to spend around 9.7% more on a product they know is sourced or manufactured sustainably, with 46% saying they would do so explicitly because they want to reduce their environmental footprint, according to a 2024 PwC report. Sustainable practices consumers look for from companies include production methods, packaging, and water conservation. But despite the growing consciousness around being more environmentally responsible, consumer actions don't always align with their values. In psychology, this is defined as the "say-do gap": the phenomenon wherein people openly express concern and intention around an issue, but fail to take tangible action to make a change. According to the Harvard Business Review in 2019, most consumers (65%) say they want to buy from brands that promote sustainability, but only 1 in 4 follow through. So why don't people actually shop sustainably, despite how much they express a preference for eco-friendly products—and how can we close the gap? The RealReal examined reports from the Harvard Business Review and other sources to explore why some shoppers want to buy sustainably but struggle to follow through. This lack of action isn't due to a lack of caring—in many cases, it's hard to know how to be a sustainable consumer and other factors are often outside of shoppers' control. But the more people shop sustainably, the easier and more accessible that market will be for everyone—making it much easier for folks to buy aligned with their values. There are many obstacles preventing shoppers from upholding eco-friendly habits as much as they may want to—but not all of these barriers are necessarily real, or accurately understood. Shopping sustainably simply isn't convenient or accessible for many. Those who live in apartment buildings are 50% less likely to recycle , according to Ipsos. Reasons for this can vary from lack of space to buildings being excluded altogether because of recycling contamination issues. Many believe that sustainable products are too expensive or of a lower quality. The former is often true, which does create a hurdle for many: The manufacturing processes and materials for sustainable products are pricey. For instance, organic cotton requires an intensive production process free of certain chemicals or pesticides; by definition, true eco-friendly products can't be mass-produced, further upping their price tag. Using recycled materials for packaging, or obtaining an eco certification, can also be expensive. However, although the narrative of eco-friendly products being more expensive is true, there is often more of an effort to use better quality materials that last longer than their noneco-friendly counterparts. This could end up saving consumers money in the long run: By paying more upfront, they can get more wear out of sustainable fashion, for instance. There is also undeniable political rhetoric surrounding eco-friendly products—however, despite many Conservative politicians decrying sustainable products, members of all generations are increasingly choosing to prioritize shopping sustainably regardless of their political affiliation, according to research from NYU Stern Center for Sustainable Business . This finding shows a trend toward seeing sustainability as a nonpartisan subject everyone can benefit from, no matter where they lie on the political spectrum. Some might think eco-friendly clothing, in particular, is not fashion-forward; after all, many of the top clothing retailers in the world partake in fast fashion. However, brands are increasingly being recognized as 'cool' and 'trendy' for supporting environmentally ethical practices, particularly as younger generations prioritize sustainability, as noted before. Many increasingly popular online stores are taking advantage of this paradigm shift by offering secondhand shopping options that are not only fashionable, but also more affordable, like ThredUp or Poshmark. Additionally, many legacy large-name brands are hopping on the sustainability movement and are gaining appreciation from loyal customers. Amazon's Climate Pledge Friendly program partners with third-party certification bodies to make it easier for shoppers to identify eco-friendly products as they browse the website. H&M's newly launched H&M Rewear program debuts a resale platform that allows the resale of all clothing brands—not just their own. Similarly, Patagonia's Worn Wear program allows shoppers to trade in and buy used gear and clothing. The federal government is also working to close this gap. The Environmental Protection Agency's Safer Choice program is attempting to make sustainable shopping easier for consumers and companies alike. It includes a directory of certified products, a list of safer chemicals to look out for on labels, a "Safer Choice" label that products can earn to denote they are eco-friendly, and resources for manufacturers looking to adopt more sustainable practices. Most of all, though, the biggest way shoppers can shift toward sustainable shopping is through their behaviors and attitudes amongst their peers and communities. Studies show that humans largely care what others think of their actions; the more shoppers make environmentally conscious shopping the norm, the more others will follow suit. From an economic perspective, the more consumers shop eco-friendly, the more affordable and accessible these products will become, too: Sustainable products are currently more expensive because they are not in high demand. Once demand rises, production rates and prices can lower, making these products more accessible for all. Story editing by Carren Jao. Additional editing by Kelly Glass. Copy editing by Kristen Wegrzyn. This story originally appeared on The RealReal and was produced and distributed in partnership with Stacker Studio. Get local news delivered to your inbox!
President-elect Donald Trump weighed in on a simmering feud among MAGA allies over H-1B worker visas, telling the New York Post that he supports the program, according to the outlet. Trump told the New York Post that he has “always liked the visas.” The H-1B visa program allows employers to temporarily hire non-U.S. citizens for highly skilled jobs. > Philadelphia news 24/7: Watch NBC10 free wherever you are “I have many H-1B visas on my properties. I’ve been a believer in H-1B. I have used it many times. It’s a great program,” he said, according to the outlet’s report. A spokesperson for the Trump transition team did not immediately respond to a request for comment. During his first term, the Trump administration implemented rules that would have cut the number of H-1B visas issued each year. The rules, however, were ultimately struck down in court. In recent days, MAGA world has been embroiled in a debate over the program, with one faction defending the visas and another faction arguing that the program allows foreigners to take American jobs. Trump allies, including Elon Musk and Vivek Ramaswamy, argued in online posts that the visa program benefits the country. The latest news on Donald Trump's presidency Musk said in a post this week that “the number of people who are super talented engineers AND super motivated in the USA is far too low.” Musk, who was born in South Africa and is a naturalized U.S. citizen, said that the reason he and others who built SpaceX and Tesla are in the U.S. is because of the H-1B program. “Take a big step back and F--- YOURSELF in the face,” he said in a post . “I will go to war on this issue the likes of which you cannot possibly comprehend.” Musk said in a post to X that “those contemptible fools must be removed from the Republican Party,” later clarifying that he was referring to “those in the Republican Party who are hateful, unrepentant racists.” Musk’s posts came in reply to a post from Scott Adams, the creator of the “Dilbert” comic, who said “MAGA is taking a page from Democrats on how to lose elections while feeling good about themselves.” Separately, Ramaswamy, who is partnering with Musk to lead Trump’s nongovernmental Department of Government Efficiency, argued in a post to X that he hopes American culture again prioritizes “hard work over laziness.” Ramaswamy also said in a post to X on Friday that the H-1B visa program “is badly broken & should be replaced with one that focuses on selecting the very best of the best (not a lottery), pro-competitive (no indentured service to one company), and de-bureaucratized.” Republicans who criticized H-1B visas included far-right activists Laura Loomer and Steve Bannon. Former South Carolina Gov. Nikki Haley also weighed in, calling it “lazy” for the “tech industry to automatically go to foreign workers for their needs.” “Invest in our American workforce,” she said in a post to X on Friday. “We must invest in Americans first before looking elsewhere.” Musk also faced accusations of censoring critics after more than a dozen conservatives, including Loomer, said their blue badge verification on X had been revoked after they criticized Musk over his views on immigration. This story first appeared on NBCNews.com. More from NBC News:
Canada can't say when it will clear 140,000 backlogged cases for First Nations kidsUnretired two-time Pro Bowl LB Shaquil Barrett signs to resume career with Tampa Bay BuccaneersFOXBOROUGH, Mass. (AP) — Drake Maye received a nice ovation from the Gillette Stadium crowd when he returned to Saturday’s game after it appeared the New England Patriots had lost their rookie quarterback to another head injury. By the fourth quarter, those fans who chose to stick around until the end of a 40-7 lopsided loss to the Los Angeles Chargers chose to voice their displeasure in a season in which very little has gone right for the former NFL powerhouse. Chants of “Fire Mayo!” reverberated throughout the stadium, which was a quarter full by game’s end. “You hear those things. At the same time, they paid to sit in the seats, and we’ve got to play better. If we play better, we don’t have to hear that stuff,” head coach Jerod Mayo said after the Patriots dropped their sixth straight game. Instead of building off last week’s strong effort at Buffalo, New England took another series of steps backward in the season’s penultimate game. With another game against the Bills on tap next weekend, questions concerning the future of Mayo and several assistant coaches – mostly notably offensive coordinator Alex Van Pelt and defensive coordinator DeMarcus Covington – figure to intensify. “I’m always under pressure and it’s been that way for a very long time, not just when I became the head coach of the Patriots. I’m okay. Look, I always do what’s best for the team,” Mayo said. “I have full confidence in the staff. I have full confidence in the players in (the locker room). I think again, it just comes down to being consistent across the board.” Remember, the Patriots parted ways with six-time Super Bowl winner Bill Belichick following last year’s dismal 4-13 record. The coaching change didn’t produce the desired upward swing, with New England staring at the possibility of producing fewer wins in Mayo’s first season. “I’m just tired of losing. I’m trying to be in the playoffs and have a winning season,” said second-year receiver DeMario Douglas, who connected with Maye for New England’s lone touchdown. The most important asset in the Patriots’ rebuilding efforts, Maye was questionable to return with a head injury after taking a blow to the helmet in the first quarter. The No. 3 overall pick from this spring’s NFL draft scrambled near the sideline on third down of the Patriots’ first possession when he was hit by Chargers cornerback Cam Hart. Maye stayed down on the turf for several seconds before eventually getting up and jogging off the field. He briefly sat on the bench before going to the medical tent for evaluation. He was replaced by backup Jacoby Brissett, but for only one series that ended with a three-and-out. After further evaluation in the locker room, Maye returned to the game for the Patriots’ third series at the 10:15 mark of the second quarter. The 22-year-old was knocked out of the Patriots’ Week 8 win over the New York Jets after he suffered a blow to the back of his head. “Just kind of got my bell rung on the first drive. I feel good, I still feel good, and then I was good to go,” Maye said afterward. To his teammates, it wasn't a shock to see Maye re-enter the game after taking a blow to the head. On his first play back under center, Maye took off for a 9-yard run and drew an unnecessary roughness penalty. “He didn’t have to come back, but he did. That gave everyone a lot of confidence,” Patriots wide receiver Kayshon Boutte said. Maye set a Patriots rookie franchise record for touchdown passes in consecutive games (eight) when he connected with Douglas on a play on which the Chargers called for defensive offsides. He also turned the ball over for the eighth straight game – a fumble on a pitch attempt to Douglas that Los Angeles turned into points to make it 17-0 in the second quarter. “I’ve got to give him a better ball to catch. That falls back on me,” Maye said. It appears the Patriots dodged a bullet with respect to Maye and his health. Now, the focus shifts back to Mayo and what his 2025 status. “I think the biggest thing was you don’t see those guys quitting. I think the score may not tell that today, but I feel like the guys are still wanting to win. We’re still leaving it out there every week, and I think that was kind of my message to the team,” Maye said. AP NFL: https://apnews.com/hub/nflIndustry body CII on Sunday pitched for cuts in personal income tax rates and excise duty on fuel and introducing consumption vouchers in the upcoming budget to boost consumption. Engineering Exports Promotion Council (EEPC) has proposed a faceless GST audit system to support micro, small and medium enterprises (MSMEs). ET Year-end Special Reads What kept India's stock market investors on toes in 2024? India's car race: How far EVs went in 2024 Investing in 2025: Six wealth management trends to watch out for "Domestic consumption has been critical to India's growth story, but inflationary pressures have somewhat eroded the purchasing power of consumers," said Chandrajit Banerjee, director general of Confederation of Indian Industry (CII). "Government interventions could focus on enhancing disposable incomes and stimulating spending to sustain economic momentum." Persistent food inflation pressures impinge upon low-income rural households who allocate a larger share to food in their consumption basket, Banerjee said. Retail inflation fell to 5.5% in November, after rising to a high of 6.2% in October. Reducing excise duty on fuel, which constitutes a significant part of household expenses, would lower inflation and increase disposable income, CII said. It also suggested reducing the marginal tax rate for personal income up to ₹20 lakh per annum, which would encourage higher consumption and enhance tax revenue. "The gap between the highest marginal rate for individuals at 42.74% and the normal corporate tax rate at 25.17 %, is high," CII said in its release. Additionally, it proposed raising the daily minimum wage under the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) to ₹375 from ₹267, which would involve an additional expenditure of ₹42,000 crore. The annual payout under the PM-Kisan scheme should also be raised to ₹8,000 from ₹6,000, incurring an additional cost of ₹20,000 crore, assuming 100 million beneficiaries, the industry body said. 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CII suggested the introduction of consumption vouchers for specific items and timeframes. These vouchers could target Jan-Dhan account holders who are not beneficiaries of other welfare schemes. Banerjee highlighted a decline in household savings due to lower returns on bank deposits compared to equities and mutual funds, combined with higher tax burdens on interest income. To address this, CII recommended reducing the tax rate on interest income from deposits and shortening the lock-in period for fixed deposits with preferential tax treatment from five years to three years. EEPC India has proposed the introduction of a faceless goods and services tax (GST) audit system. "This system, by using technology and ensuring anonymity, will reduce compliance costs...(and) streamline procedures, allowing MSMEs to focus on growth and innovation," said Pankaj Chadha, chairman of EEPC India. Nominations for ET MSME Awards are now open. The last day to apply is December 31, 2024. Click here to submit your entry for any one or more of the 22 categories and stand a chance to win a prestigious award. (You can now subscribe to our Economic Times WhatsApp channel )
Major Victorian opposition leadership change revealed