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4 slot motherboard December 14, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Columbia University Since 2006, Ruben Gonzalez's Columbia lab has used single-molecule light microscopy to study the structural dynamics of biomolecules. In lay person's terms, that means: they use hyper-powerful microscopes that generate movies of what individual molecules look like as they perform the actions that make our bodies tick. Gonzalez is a professor of biophysical chemistry in Columbia's Faculty of Arts and Sciences and at the Columbia University Irving Medical Center, and will become Dean of Science in the Faculty of Arts and Sciences in January. In a new paper out this month in the journal Nature , he and his lab describe a major new finding about how the eIF4F protein interacts with messenger RNAs. Columbia News spoke with Gonzalez about his research, and how his latest finding could affect drug treatments for diseases like cancer. Can you explain your lab's work broadly? My lab is interested in trying to understand how the motions of biomolecules—molecules produced by the body—contribute to their functions. We record movies to give us a data-informed sense of what those motions look like. That allows us to understand how the biology really functions, which in turn can help us and other scientists think about how we might control that biology by manipulating such motions, providing a new paradigm for developing therapies to tackle diseases like cancer. There are many cases where drugs act by impairing a biomolecular motion, so understanding that motion is crucial. The dream is to be able to record these movies at atomic scales and in real-time. But we're not there yet. What led you to record these movies? For a long time, static images of biomolecules at atomic scales exhibited blurry regions, which led scientists to the conclusion that parts of the biomolecule were moving, and that such motions might be important to biology. It sort of captured my imagination. What are the moving parts, and where are they moving? What is the timing of these motions, and why is all of this important? Those kinds of questions have really been the driving feature of all we do in the lab. We do a lot of technology development in my lab. We build these microscopes, we optimize them, we continuously push the technology. We also have a whole group that develops computational algorithms and software for the analysis of the data that comes from these. What does the new paper in Nature show? To make proteins, which are the building blocks of everything in our cells and in our bodies, cells need to prepare messenger RNAs (mRNAs), the molecules that carry the building instructions. They do that with the help of a protein called eukaryotic initiation factor 4F, or eIF4F, that must converge at a certain location at one end of the mRNA, which we call the mRNA "cap." Using our movie technology and led by graduate students Riley Gentry and Nicholas Ide, we discovered—quite unexpectedly—that eIF4F doesn't just directly assemble at the cap as everyone had always assumed. Instead, it 'hops' along the mRNA trying to identify the cap. One reason this is important is that drugs, such as anticancer drugs , that aim to disrupt this process in order to stop dangerous cells like cancer cells from proliferating currently target the direct assembly of eIF4F at the cap. Our finding provides a deeper understanding of how eIF4F actually finds its way to the cap on the mRNA, which will help us develop more targeted therapies for cancer and other diseases. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . What makes the finding significant? There are a number of things that make this a significant finding. It's really redefining something fundamental about this critical biological function, in a way that will rewrite what's in textbooks. It also answers some big, decades-old questions that we and others have had, which is that we've known for decades that different regions and properties of the mRNA that are far away from the cap can influence the ability of eIF4F to converge at the cap, but no one has ever been able to figure out how that could be, and our findings help explain this. Another reason is that if you can develop drugs that influence the search that eIF4F does along the mRNA, it could have big implications. It could help us more precisely target particular mRNAs, manipulating the production of the specific proteins at the heart of the disease. That could mean that future cancer drugs would use something more like a scalpel than a sledgehammer to stop molecular motions that have gone awry, rather than halting a whole bunch of processes that include the dangerous ones you want to stop but also good ones you would want to leave unimpaired. More information: Riley C. Gentry et al, The mechanism of mRNA cap recognition, Nature (2024). DOI: 10.1038/s41586-024-08304-0 Journal information: Nature Provided by Columbia UniversityCanada Prepares for Possible Retaliatory Tariffs Amid US Trade Tensions

Johnson also contributed 10 rebounds and eight assists for the Golden Eagles (4-3). Daniel Egbuniwe added 16 points while going 5 of 13 from the floor, including 2 for 7 from 3-point range, and 4 for 4 from the line and also had six rebounds. Kyle Layton shot 5 for 10, including 5 for 8 from beyond the arc to finish with 15 points. Kaleb Scott finished with 14 points and seven rebounds for the Blue Hose (5-4). Jaylen Peterson added 11 points and 11 rebounds for Presbyterian. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .John Kerry warns US is 'on the brink' of declaring a climate emergencyWALTHAM, Mass.--(BUSINESS WIRE)--Dec 6, 2024-- Vicarious Surgical Inc. (“Vicarious Surgical” or the “Company”) (NYSE: RBOT, RBOT WS), a next-generation robotics technology company seeking to improve lives by transforming robotic surgery, today announced the pending departure of William Kelly, its Chief Financial Officer (CFO), to pursue other career opportunities, after nearly four years of dedicated service with the Company. Mr. Kelly has served as Vicarious Surgical’s CFO since January 2021. He will assist the Company to ensure minimal disruption and a successful transition of responsibilities prior to his departure, which is slated for January 2, 2025. “On behalf of the Company and Board, I want to extend my sincerest gratitude to Bill for his significant contribution over the last few years,” said Adam Sachs, Co-Founder and Chief Executive Officer. “Bill has been an incredible asset to Vicarious Surgical, and we wish him all the best in his future endeavors.” Mr. Kelly added “My tenure at Vicarious Surgical has been a period of significant progress and accomplishment, both for the Company and for me personally. I am deeply grateful for the opportunities I have been afforded and the collaborative spirit of the entire team. I depart with immense pride in our collective achievements and unwavering confidence in the Company's continued success under its strong leadership.” The Company has initiated a CFO succession process and will provide updates as appropriate. About Vicarious Surgical Founded in 2014, Vicarious Surgical is a next generation robotics company, developing a unique disruptive technology with the multiple goals of substantially increasing the efficiency of surgical procedures, improving patient outcomes, and reducing healthcare costs. The Company’s novel surgical approach uses proprietary human-like surgical robots to virtually transport surgeons inside the patient to perform minimally invasive surgery. The Company is led by an experienced team of technologists, medical device professionals and physicians, and is backed by technology luminaries including Bill Gates, Vinod Khosla’s Khosla Ventures, Innovation Endeavors, Jerry Yang’s AME Cloud Ventures, Sun Hung Kai & Co. Ltd and Philip Liang’s E15 VC. The Company is headquartered in Waltham, Massachusetts. Learn more at www.vicarioussurgical.com . Forward-Looking Statements This press release includes “forward-looking statements” within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. The company’s actual results may differ from its expectations, estimates, and projections and, consequently, you should not rely on these forward-looking statements as predictions of future events. All statements other than statements of historical facts contained herein, are forward-looking statements that reflect the current beliefs and expectations of management. These forward-looking statements involve significant risks and uncertainties that could cause the actual results to differ materially from those discussed in the forward-looking statements. Most of these factors are outside Vicarious Surgical’s control and are difficult to predict. Factors that may cause such differences include, but are not limited to: the ability to maintain the listing of Vicarious Surgical’s Class A common stock on the New York Stock Exchange; the approval, commercialization and adoption of Vicarious Surgical’s initial product candidates and the success of its single-port surgical robot, called the Vicarious Surgical System, and any of its future product candidates and service offerings; changes in applicable laws or regulations; the ability of Vicarious Surgical to raise financing in the future; the success, cost and timing of Vicarious Surgical’s product and service development activities; the potential attributes and benefits of Vicarious Surgical’s product candidates and services; Vicarious Surgical’s ability to obtain and maintain regulatory approval for the Vicarious Surgical System, and any related restrictions and limitations of any approved product; the size and duration of human clinical trials for the Vicarious Surgical System; Vicarious Surgical’s ability to identify, in-license or acquire additional technology; Vicarious Surgical’s ability to maintain its existing license, manufacture, supply and distribution agreements; Vicarious Surgical’s ability to compete with other companies currently marketing or engaged in the development of products and services that Vicarious Surgical is currently marketing or developing; the size and growth potential of the markets for Vicarious Surgical’s product candidates and services, and its ability to serve those markets, either alone or in partnership with others; the pricing of Vicarious Surgical’s product candidates and services and reimbursement for medical procedures conducted using its product candidates and services; the company’s estimates regarding expenses, revenue, capital requirements and needs for additional financing; Vicarious Surgical’s financial performance; economic downturns, political and market conditions and their potential to adversely affect Vicarious Surgical’s business, financial condition and results of operations; Vicarious Surgical’s intellectual property rights and its ability to protect or enforce those rights, and the impact on its business, results and financial condition if it is unsuccessful in doing so; and other risks and uncertainties indicated from time to time in Vicarious Surgical’s filings with the SEC. Vicarious Surgical cautions that the foregoing list of factors is not exclusive. The company cautions readers not to place undue reliance upon any forward-looking statements, which speak only as of the date made. Vicarious Surgical does not undertake or accept any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements to reflect any change in its expectations or any change in events, conditions or circumstances on which any such statement is based. View source version on businesswire.com : https://www.businesswire.com/news/home/20241206242926/en/ CONTACT: Investors Kaitlyn Brosco Vicarious Surgical Kbrosco@vicarioussurgical.com Media Inquiries media@vicarioussurgical.com KEYWORD: MASSACHUSETTS UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: MEDICAL SUPPLIES TECHNOLOGY OTHER HEALTH HEALTH ROBOTICS HEALTH TECHNOLOGY OTHER TECHNOLOGY MEDICAL DEVICES HOSPITALS SURGERY HARDWARE SOURCE: Vicarious Surgical Inc. Copyright Business Wire 2024. PUB: 12/06/2024 04:05 PM/DISC: 12/06/2024 04:05 PM http://www.businesswire.com/news/home/20241206242926/en

Buchanan scores 28 off the bench, Boise State downs South Dakota State 83-82

The Associated Press

COMMERCE, Texas (AP) — Scooter Williams Jr. had 19 points in East Texas A&M's 68-67 victory over Abilene Christian on Wednesday. Williams added six rebounds and three steals for the Lions (2-10). Khaliq Abdul-Mateen added 17 points while going 3 of 8 and 11 of 12 from the free-throw line while he also had five assists and three steals. The Lions snapped a seven-game slide. Quion Williams led the Wildcats (7-5) in scoring, finishing with 17 points and seven assists. Leonardo Bettiol added 16 points and seven rebounds for Abilene Christian. Hunter Jack Madden had 13 points. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar . For copyright information, check with the distributor of this item, Data Skrive.A federal appeals court panel on Friday unanimously upheld a law that could lead to a ban on TikTok in a few short months, handing a resounding defeat to the popular social media platform as it fights for its survival in the U.S. The U.S. Court of Appeals for the District of Columbia Circuit denied TikTok's petition to overturn the law — which requires TikTok to break ties with its China-based parent company ByteDance or be banned by mid-January — and rebuffed the company's challenge of the statute, which it argued had ran afoul of the First Amendment. “The First Amendment exists to protect free speech in the United States,” said the court's opinion, which was written by Judge Douglas Ginsburg. “Here the Government acted solely to protect that freedom from a foreign adversary nation and to limit that adversary’s ability to gather data on people in the United States.” TikTok and ByteDance — another plaintiff in the lawsuit — are expected to appeal to the Supreme Court, though its unclear whether the court will take up the case. “The Supreme Court has an established historical record of protecting Americans’ right to free speech, and we expect they will do just that on this important constitutional issue," TikTok spokesperson Michael Hughes said in a statement. “Unfortunately, the TikTok ban was conceived and pushed through based upon inaccurate, flawed and hypothetical information, resulting in outright censorship of the American people,” Hughes said. Unless stopped, he argued the statute “will silence the voices of over 170 million Americans here in the US and around the world on January 19th, 2025.” Though the case is squarely in the court system, its also possible the two companies might be thrown some sort of a lifeline by President-elect Donald Trump, who tried to ban TikTok during his first term but said during the presidential campaign that he is now against such action. The law, signed by President Joe Biden in April, was the culmination of a years-long saga in Washington over the short-form video-sharing app, which the government sees as a national security threat due to its connections to China. The U.S. has said it’s concerned about TikTok collecting vast swaths of user data, including sensitive information on viewing habits, that could fall into the hands of the Chinese government through coercion. Officials have also warned the proprietary algorithm that fuels what users see on the app is vulnerable to manipulation by Chinese authorities, who can use it to shape content on the platform in a way that’s difficult to detect — a concern mirrored by the European Union on Friday as it scrutinizes the video-sharing app’s role in the Romanian elections. TikTok, which sued the government over the law in May, has long denied it could be used by Beijing to spy on or manipulate Americans. Its attorneys have accurately pointed out that the U.S. hasn’t provided evidence to show that the company handed over user data to the Chinese government, or manipulated content for Beijing’s benefit in the U.S. They have also argued the law is predicated on future risks, which the Department of Justice has emphasized pointing in part to unspecified action it claims the two companies have taken in the past due to demands from the Chinese government. Friday’s ruling came after the appeals court panel, composed of two Republican and one Democrat appointed judges, heard oral arguments in September. In the hearing, which lasted more than two hours, the panel appeared to grapple with how TikTok’s foreign ownership affects its rights under the Constitution and how far the government could go to curtail potential influence from abroad on a foreign-owned platform. On Friday, all three of them denied TikTok’s petition. In the court's ruling, Ginsburg, a Republican appointee, rejected TikTok's main legal arguments against the law, including that the statute was an unlawful bill of attainder or a taking of property in violation of the Fifth Amendment. He also said the law did not violate the First Amendment because the government is not looking to "suppress content or require a certain mix of content” on TikTok. “Content on the platform could in principle remain unchanged after divestiture, and people in the United States would remain free to read and share as much PRC propaganda (or any other content) as they desire on TikTok or any other platform of their choosing,” Ginsburg wrote, using the abbreviation for the People’s Republic of China. Judge Sri Srinivasan, the chief judge on the court, issued a concurring opinion. TikTok’s lawsuit was consolidated with a second legal challenge brought by several content creators - for which the company is covering legal costs - as well as a third one filed on behalf of conservative creators who work with a nonprofit called BASED Politics Inc. Other organizations, including the Knight First Amendment Institute, had also filed amicus briefs supporting TikTok. “This is a deeply misguided ruling that reads important First Amendment precedents too narrowly and gives the government sweeping power to restrict Americans’ access to information, ideas, and media from abroad,” said Jameel Jaffer, the executive director of the organization. “We hope that the appeals court’s ruling won’t be the last word.” Meanwhile, on Capitol Hill, lawmakers who had pushed for the legislation celebrated the court's ruling. "I am optimistic that President Trump will facilitate an American takeover of TikTok to allow its continued use in the United States and I look forward to welcoming the app in America under new ownership,” said Republican Rep. John Moolenaar of Michigan, chairman of the House Select Committee on China. Democratic Rep. Raja Krishnamoorthi, who co-authored the law, said “it's time for ByteDance to accept” the law. To assuage concerns about the company’s owners, TikTok says it has invested more than $2 billion to bolster protections around U.S. user data. The company has also argued the government’s broader concerns could have been resolved in a draft agreement it provided the Biden administration more than two years ago during talks between the two sides. It has blamed the government for walking away from further negotiations on the agreement, which the Justice Department argues is insufficient. Attorneys for the two companies have claimed it’s impossible to divest the platform commercially and technologically. They also say any sale of TikTok without the coveted algorithm - the platform’s secret sauce that Chinese authorities would likely block under any divesture plan - would turn the U.S. version of TikTok into an island disconnected from other global content. Still, some investors, including Trump’s former Treasury Secretary Steven Mnuchin and billionaire Frank McCourt, have expressed interest in purchasing the platform. Both men said earlier this year that they were launching a consortium to purchase TikTok’s U.S. business. This week, a spokesperson for McCourt’s Project Liberty initiative, which aims to protect online privacy, said unnamed participants in their bid have made informal commitments of more than $20 billion in capital.

No 2025 Budget For Labour Ministry, NECO, UI, 21 Others, Reps Insist

In April, the UFC announced that for fighters that would offer more mobility and flexibility while reducing eye pokes and hand injuries. The new gloves, coined "3Eight/5Eight" (the 3Eight glove is for three-round fights, and the 5Eight gold glove for championship fights), premiered at UFC 301 in June. It marked the first time since fingerless gloves became mandatory for all fighters back in 1997 that the fight glove had evolved. "This redesign will truly be a game changer for the entire sport of MMA," UFC CEO and president Dana White said in the April statement. "These gloves will feel lighter, fit fighters' hands better, prevent injuries and provide maximum flexibility during the fights." But after five months -- 21 UFC events (pay-per-views and Fight Nights) and 10 "Dana White's Contender Series" cards -- and return to the original fingerless gloves. "The new gloves are now the old gloves," UFC CEO Dana White said in a surprise announcement ahead of UFC 309 last weekend. "You know what, there were good intentions with the new gloves. We spent a lot of time, energy and money on them. ... It didn't work out and it is what it is." The abrupt about-face came as a shocker.. Interestingly enough, the switch came just days after independent researcher and data scientist Nate Latshaw posted a detailed report demonstrating a significant drop in knockouts from when the new gloves were introduced. Comparing the knockout rate of the old gloves -- now referred to as "classic" by the UFC -- from Jan. 1, 2023, to May 31, 2024, to when the new gloves were in play from June 1 to Nov. 9, Latshaw's findings showed an 8.5% drop off in knockout rates. Between Latshaw's report gaining traction on social media and UFC heavyweight champion balking at the fit and feel of the new gloves ahead of his fight with at UFC 309, the timing of the announcement felt like a little more than a coincidence. "The shape, the curve in your hands, they're very uncomfortable for me," Jones said last week in New York. "I was actually really stressed thinking, 'How am I going to go into fight week wearing these gloves that I don't even really want to train in?'" When the switch was announced, several UFC fighters breathed a sigh of relief over the promotion reversing course. "When I first got the new gloves, I didn't like them," lightweight told ESPN. "I think they look and felt cheap. The material was not very good, and I didn't like the design." Moicano had one of his best performances with the new gloves, a decisive TKO victory over in September. The fight was stopped due to a doctor's intervention. "I was thinking to myself, 'This is a bad glove,' and then I had an awesome performance," Moicano said. "Maybe it actually was the glove? I don't know. But I don't think it affected my performance at all." Women's flyweight contender echoed Moicano's assessment of the gloves feeling "cheap." "I wasn't opposed to the new gloves when they announced they were coming, but when I saw them, I didn't like how they looked," Blanchfield said. "I didn't like the design, and the colors looked tacky and cheap. They looked like something you can buy from a sporting goods store." Blanchfield, who relies heavily on her wrestling and grappling, found that the gloves felt restrictive and affected her grip during her unanimous decision victory over earlier this month. "It felt harder to close my hands because the fingers were so tight," she said. While Blanchfield eventually broke in the new gloves during training, she was issued a new pair ahead of her fight. "I had my cornermen working on the gloves the entire time in the locker room," Blanchfield said. "Just pulling at them, stretching them out, really trying to loosen them up for me. They literally had to make a tool that everyone in the locker room passed around to loosen up the fingers." Strawweight , who lost a decision to in the new gloves in August, said they "felt like having memory foam wrapped around your fist." "I hated them at first," Hill said. "But after training in them for a while, I didn't mind them as much. They are way thinner and aren't formed at all. The old gloves had more of a natural curve to them." The restrictive feel that Hill and Blanchfield are referring to was originally installed to prevent fighters from extending their fingers and committing eye-poke fouls. But both said that the intent didn't match the outcome. "I don't think they did anything for eye pokes," Hill said. "Until you break them in, it's harder to make a closed fist." What about the decrease in knockouts? Latshaw, a data scientist with a focus on quantitative analysis in MMA, noted that the research didn't include the variety of ways to obtain a knockout. "I continue to caution against drawing any particularly strong conclusions from the data," Latshaw told ESPN. "I'm looking at all knockdowns and all knockouts, which is really not a good way to study the impact of the gloves because I'm including knockouts and knockdowns that come from head kicks, elbows, knees, things like that where the gloves aren't impactful." While the old gloves are now back in play, it doesn't mean the "new" gloves are gone forever...yet. A UFC spokesperson told ESPN that "some fighters may still be wearing the new gloves in upcoming events while UFC re-stocks its inventory of the classic gloves." According to White, fighters will use the "classic" gloves at UFC 310 on Dec. 7. "They tried a new idea, and it ended up being a mistake, so they decided to go back to the old gloves once they saw the gloves weren't working out," Moicano said. "That's better than to keep trying to push a glove on us that everyone hates. This is what was good for business. "I don't know if we'll ever get the perfect glove, but I hope they keep trying."

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The Wildest Political Moments Of 2024No. 7 Tennessee extends its season-opening winning streak to 7 games in 78-35 win over UT MartinRiles, Pierre give Titans two more college football players