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Ray'Sean Taylor scores 18 as SIU Edwardsville cruises past Eureka 100-52Offering patients an injection is more effective than the current care of steroid tablets and cuts the need for further treatment by 30%, according to a study. Benralizumab is a monoclonal antibody that targets specific white blood cells, called eosinophils, to reduce lung inflammation. It is currently used as a repeat treatment for severe asthma at a low dose, but a new clinical trial has found that a higher single dose can be very effective if injected at the time of a flare-up. The findings, published in the Lancet Respiratory Medicine, included 158 people who needed medical attention in A&E for their asthma or COPD attack (COPD is a group of lung conditions that cause breathing difficulties). Patients were given a quick blood test to see what type of attack they were having, with those suffering an “eosinophilic exacerbation” involving eosinophils (a type of white blood cell) being suitable for treatment. Around 50% of asthma attacks are eosinophilic exacerbations, as are 30% of COPD ones, according to the scientists. The clinical trial, led by King’s College London and carried out at Oxford University Hospitals NHS Foundation Trust and Guy’s and St Thomas’ NHS Foundation Trust, saw patients randomly split into three groups. One group received the benralizumab injection and dummy tablets, another received standard care (prednisolone steroids 30mg daily for five days) and a dummy injection, and the third group received both the benralizumab injection and steroids. After 28 days, respiratory symptoms of cough, wheeze, breathlessness and sputum were found to be better in people on benralizumab. And after 90 days, there were four times fewer people in the benralizumab group who failed treatment compared with those receiving steroids. Treatment with the benralizumab injection also took longer to fail, meaning fewer visits to a GP or hospital for patients, researchers said. Furthermore, people also reported a better quality of life on the new regime. Scientists at King’s said steroids can have severe side-effects such as increasing the risk of diabetes and osteoporosis, meaning switching to benralizumab could provide huge benefits. Lead investigator Professor Mona Bafadhel, from King’s, said: “This could be a game-changer for people with asthma and COPD. “Treatment for asthma and COPD exacerbations have not changed in 50 years, despite causing 3.8 million deaths worldwide a year combined. “Benralizumab is a safe and effective drug already used to manage severe asthma. “We’ve used the drug in a different way – at the point of an exacerbation – to show that it’s more effective than steroid tablets, which is the only treatment currently available.” Researchers said benralizumab could also potentially be administered safely at home or in a GP practice, as well as in A&E. First author Dr Sanjay Ramakrishnan, clinical senior lecturer at the University of Western Australia, said: “Our study shows massive promise for asthma and COPD treatment. “COPD is the third leading cause of death worldwide but treatment for the condition is stuck in the 20th century. “We need to provide these patients with life-saving options before their time runs out.” Dr Samantha Walker, director of research and innovation at Asthma and Lung UK, welcomed the findings but said: “It’s appalling that this is the first new treatment for those suffering from asthma and COPD attacks in 50 years, indicating how desperately underfunded lung health research is.” AstraZeneca provided the drug for the study and funded the research, but had no input into trial design, delivery, analysis or interpretation.

The Petroleum Products Retail Outlet Owners Association of Nigeria (PETROAN), has signed an agreement with the Dangote Refinery and Petrochemicals to avert the scarcity of petrol during the yuletide and beyond. This was contained in a statement by National Public Relations Officer, PETROAN, Dr Joseph Obele, yesterday in Abuja. According to the statement, the sealing of a transactional deal with Dangote Refinery was the aftermath of a successfully buyer-seller negotiation and agreement secured by PETROAN at a strategic meeting as PETROAN National President, Dr Billy Gillis Hary, on Monday, December 2, led the negotiation team of PETROAN to a fruitful strategic business meeting with the management of Dangote Refinery at the complex in Lagos. It stated that PETROAN is impressed with the outcome of the strategic business meeting which, it said, was evidenced with the establishment of Seller/Buyer relationship, reservation of monthly volume for PETROAN, payment modalities and a favourable rate. It added that the association sealed a purchase deal with the refinery. The statement read: “PETROAN National President commended the Vice President of Dangote group & Managing Director of Dangote Refinery, Mr Devakumar V. G. Edwin, for his cooperation and strategies deployed so far to make petroleum products available to all Nigerians throughout the end of year festivities and beyond. “We reserved the right not to make public the business terms and conditions, even as we express optimism that the greatest beneficiaries in all shall be the general public as it concerns product availability and affordability. “The National Headquarters of Petroleum Products Retail outlets owners Association of Nigeria (PETROAN) Abuja, has expressed confidence that the measures put in place by the association following the commencement of production at the Port Harcourt refinery and fruitful deliberations with the management of Dangote Refinery will definitely avert fuel supply shortages during and after the festive season.” It added: “This was due to the efforts of the PETROAN distribution technical committee in charge of planning and execution of the zero-fuel scarcity strategy. “We are happy that Nigerians are going to travel effortlessly during this period of the year. “PETROAN dismisses any form of fuel scarcity concerns, cautioning against panic buying as it is unsafe and dangerous to stock Petroleum products at home. “It also called on stakeholders in the downstream sector to support the Management of NNPC Retail Ltd and Dangote Refinery to sustain petroleum products supply. “We hereby reassure Nigerians of PETROAN’s preparedness to ensure zero-scarcity of petroleum products during the upcoming festive season and beyond as all our retail outlets operators in all the states in Nigeria have been placed on green alert for service.”PRAGUE, Czech Republic (AP) — When the referee whistled for the free kick just outside the area, Atletico Madrid forward Julián Álvarez quickly picked up the ball and moved in position to take the shot. “When I saw the free kick, I told Rodri (Rodrigo De Paul) that I felt confident with the shot,” Álvarez said. “And it was a great goal.” Álvarez, , has not been lacking confidence lately. The Argentina forward curled in the free kick shot in the 15th minute for the first of his two goals in the team’s 6-0 rout of Brest in the Champions League on Tuesday — the team’s biggest ever away win in European competitions. “We'll keep rotating who takes the free kicks,” said Álvarez, who also found the net in the 59th. It was Álvarez’s seventh goal in the last 10 matches, and third in his last three games across all competitions. The 24-year-old had a slow start to his first season with Atletico, scoring twice in 10 matches. “It was a matter of time before we started connecting well with each other,” said Álvarez, who joined Atletico after two seasons at Manchester City. “We have to stay on this path to keep improving.” Ángel Correa also scored two goals for Atletico, with Marcos Llorente and Antoine Griezmann adding one each. “We know that in this format of the competition we need to keep adding the three points and scoring goals," Álvarez said. "It's important to get the points and the goals.” Atletico was sitting in 13th place in the 36-team league standings. ___ AP soccer: The Associated Press

The outcomes of seven ballot measures in Arizona, California and Colorado reflect the stricter approach to crime that’s been seen across much of the country recently, with voters and policymakers driven by concerns over rising retail theft, homelessness, fentanyl misuse and challenges in police recruitment and retention. Voters have decided in recent years that they prefer to adopt progressive changes to the criminal justice system “somewhat less aggressively,” said Dan Schnur, a former Republican strategist and a political communications professor at the University of Southern California and the University of California, Berkeley. “Voters are always course correctors. They’re always adjusting and readjusting, trying to calibrate policy exactly the way they want it,” Schnur said. “It’s not uncommon for them to try to pull back on a reform effort that they think might be going too far.” This year, local and state leaders in blue and red states — including California, Georgia, Louisiana, Oregon, Tennessee and Vermont — shifted away from more liberal initiatives aimed at reining in police powers and reimagining criminal legal systems. They have instead embraced harsher penalties for offenses such as retail theft and possession or distribution of certain hard drugs, added more felony and misdemeanor offenses requiring cash bail, and moved to prohibit local governments from altering police traffic stop policies. Then this month, voters in Arizona, California and Colorado overwhelmingly backed ballot measures to increase prison time for certain crimes, revoke bail for others and crack down on illegal immigration and drug trafficking. While national crime data is notoriously difficult to track and understand, violent crime and property crime across the United States decreased in 2023, continuing a downward trend since the higher crime rates of the COVID-19 pandemic, according to the FBI’s latest national crime report. Still, some individual cities and neighborhoods might be seeing higher crime rates, which could explain Americans’ views on the issue. Opinions on crime in the United States have improved over the past year, according to Gallup’s annual crime survey. Fewer people compared with last year believe national crime has increased or consider crime an “extremely” or “very” serious problem — but a majority of U.S. adults, 56 percent, still do. Perceptions are heavily influenced by political affiliation, the survey showed. While 60 percent of Democrats believe crime has gone down over the past year, 90 percent of Republicans think it has increased. Rethinking theft and drug crimes In California, voters overwhelmingly approved Proposition 36, a measure that increases penalties for specific drug-related and theft crimes and that also reclassifies certain drug offenses as “treatment-mandated felonies.” This reclassification will allow judges to impose mental health or drug treatment requirements. Those who complete treatment would have their charges dismissed, while those who fail to meet the requirements could face up to three years in prison. “It’s not the hope or the intention to send a bunch of people to jail or prison who are using drugs. The goal is to incentivize people to engage in treatment again,” said Yolo County District Attorney Jeff Reisig, one of the measure’s authors, in an interview with Stateline. The measure aims to address issues such as retail theft, homelessness, substance use disorders and fentanyl distribution, Reisig said. Under the new law, people convicted of theft at least twice may face felony charges on their third offense, regardless of the stolen item’s value. Additionally, those caught distributing fentanyl while armed with a loaded firearm will now face felony charges and up to four years in prison. Previously, possessing fentanyl and a loaded firearm was punishable by up to one year in jail. “Our strong belief is that this will send a deterrent message to others that there are consequences again,” Reisig said. The measure also received substantial support from law enforcement agencies across the state, although it remains unclear how departments might adjust their enforcement policies. Still, Reisig said, the measure will provide law enforcement with “some real, meaningful tools” to address specific crimes. “With options for increased sentencing and mandated treatment, Prop. 36 could provide tools to address repeat offenses more effectively,” Sacramento Police spokesperson Sgt. Dan Wiseman wrote in an email to Stateline. Proposition 36 partially reverses some changes made in 2014 by another ballot measure, Proposition 47, that reduced certain theft and drug crimes from felonies to misdemeanors to address prison overcrowding. But Reisig said that this is not a complete rollback. “It was drafted to be more down the middle and just kind of bring the pendulum back to center mass,” he said. “We’re not reinventing the wheel. We’re just bringing back something that had proven success, and I think all of California is going to benefit.” But some Democrats and criminal justice advocacy groups have argued that the measure could reintroduce drug war policies and result in longer prison sentences. California voters also rejected Proposition 6 by a close margin, 53 percent-47 percent. The measure would have amended the state constitution to prohibit forcing inmates into labor as punishment. The proposal originated from a state task force examining whether California should provide reparations to Black residents. In contrast, voters in more conservative states such as Alabama and Tennessee have approved measures in recent elections to abolish involuntary servitude in their prisons. In a similar effort, Nevada voters this year approved a measure repealing constitutional language that permitted slavery and involuntary servitude as forms of criminal punishment. Schnur said Proposition 6 could have been rejected in part because California voters might have carried anti-criminal sentiment over from one ballot measure to the other. “Because Prop 36 passed by such a large margin, it’s entirely possible that many voters were already thinking in a more restrictive way about criminal justice policy, and those feelings may have moved over into their vote against Prop 6,” Schnur said. Restricting bail, recruiting police In Colorado, voters overwhelmingly approved a constitutional amendment put on the ballot by the state legislature that makes first-degree murder suspects ineligible for bail if prosecutors can demonstrate a strong enough case. Previously, the state constitution allowed only people charged with “capital offenses” to be denied bail. This change restores bail policies that were in place before Colorado repealed the death penalty in 2020. Voters also backed a pair of measures placed on the ballot through a signature-gathering campaign led by Advance Colorado, a conservative political group. One measure requires people convicted of certain violent crimes, including second-degree murder, aggravated robbery and sexual assault, to serve at least 85 percent of their sentence — up from the previous 75 percent — before becoming eligible for parole. The other ballot measure directs the legislature to allocate $350 million from the state’s general fund to help local law enforcement agencies hire additional officers, provide training and bonus pay, and establish a $1 million death benefit for the families of first responders — including police, firefighters and EMTs — killed in the line of duty. The approval of that measure could deepen Colorado’s $1 billion budget deficit, though the financial impact will depend on how quickly lawmakers implement the program. Since the measure does not specify a timeline, legislators may choose to allocate the funds gradually rather than all at once in the next budget year, according to Kristi Burton Brown, Advance Colorado’s executive vice president. Linking illegal immigration and fentanyl Arizona voters overwhelmingly passed two criminal justice measures this year: One mandates life imprisonment for people convicted of child sex trafficking; the other goes after both illegal immigration and the sale of fentanyl not made in the United States. Proposition 314 grants law enforcement the authority to arrest noncitizens who do not have legal authorization to enter or live in the United States. The law specifically targets people attempting to enter or who have entered Arizona outside official ports of entry. This measure expands police powers to address illegal immigration at the state level. Under Proposition 314, unauthorized entry into Arizona will become a Class 1 misdemeanor for a first offense and a felony for subsequent offenses. The measure also allows state judges to order deportations. However, portions of the law cannot take effect until a court — likely the U.S. Supreme Court — rules on the constitutionality of a similar law in Texas. If the Texas law is upheld and remains enforceable for at least 60 days, Arizona’s law could then go into effect. The law now is awaiting an appeals court decision, which is expected to itself be appealed to the Supreme Court no matter the ruling. And the measure adds a new state felony penalty for selling fentanyl manufactured outside the country that results in another person’s death. Some critics argue that it could lead to racial profiling and heightened community tensions, while supporters claim it will bolster border security and reduce crimes linked to illegal immigration. Immigration enforcement is usually a federal responsibility, and some critics also have raised concerns about the additional financial and operational burden local law enforcement agencies may face. Some local police departments contacted by Stateline were unsure of how the measure would be enforced, noting that they are waiting for further direction from state officials. The Phoenix Police Department said in an email to Stateline that it would continue its current enforcement practices, which prohibit officers from asking about immigration status during traffic stops unless required by state law and consensual contacts with the public, according to department spokesperson Sgt. Mayra Reeson. Under existing policies, Phoenix officers may only transport people to U.S. Immigration and Customs Enforcement if they are wanted for a criminal immigration violation and have no pending state criminal charges, or if the person has only a civil immigration violation, which includes being in the country without legal authorization, and consents to the transport. The ACLU of Arizona has vowed to explore all options to block the implementation of Proposition 314, calling it unconstitutional and harmful.

King added nine rebounds for the Huskies (8-3). LA Pratt added 15 points while going 7 of 14 from the field while they also had six rebounds. Masai Troutman shot 4 for 7 (0 for 3 from 3-point range) and 7 of 9 from the free-throw line to finish with 15 points. Robert Davis Jr. led the way for the Monarchs (3-8) with 17 points and six rebounds. Caelum Swanton-Rodger added 12 points, six rebounds and three blocks for Old Dominion. Sean Durugordon finished with 10 points. Harold Woods put up seven points in the first half for Northeastern, who led 31-26 at halftime. Northeastern turned a four-point second-half lead into a 13-point advantage with a 9-0 run to make it a 52-39 lead with 9:50 left in the half. King scored 14 second-half points in the victory. Northeastern's next game is Wednesday against UMass on the road, and Old Dominion visits UL Monroe on Saturday. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .ANN ARBOR, Mich. — Michigan coach Sherrone Moore says he’s closing in on finding his next offensive coordinator. Moore said Tuesday during a news conference at Schembechler Hall that he’s “pretty close” to wrapping up his search for the Wolverines’ next offensive mind. “I think in the next day or so, I’ll get an answer,” Moore told reporters. While the 38-year-old coach has been tight-lipped about potential candidates, ESPN’s Pete Thamel reported Tuesday night that North Carolina offensive coordinator Chip Lindsey has emerged as Michigan’s primary target . Lindsey, 50, spent the past two seasons at UNC, where he coached quarterbacks and called plays, and served as offensive coordinator at UCF in 2022. He’s also made previous stops at Troy, Auburn, Arizona State and Southern Miss. Moore has said publicly that he’s searching for someone with play-calling experience and track record of coaching quarterbacks. A week ago, Moore fired offensive coordinator and quarterbacks coach Kirk Campbell, citing a need to jumpstart the Wolverines’ struggling offense. Michigan ranked 128th in FBS in total yards (294.3) and 111th in scoring (22.3) in 2024, the primarily culprit behind the team’s 7-5 season. “The guys that I have been looking at have experience of calling plays,” Moore said. The search coincides with a major offseason for the Wolverines, who recently inked five-star quarterback Bryce Underwood, the No. 1 player in the 2025 recruiting class, and are searching for veteran quarterback help in the transfer portal. While the portal opened Monday, urgency is required if Michigan wants to bring in a player ahead of the winter term, which begins Jan. 8. Moore said interested quarterbacks have inquired about who will be the coordinator in 2025. “They are (asking) — but they trust me,” Moore said. “We’ll be in good shape.” Meanwhile, Michigan has started preparations for its ReliaQuest Bowl matchup against No. 11 Alabama on Dec. 31 (12 p.m., ESPN). Tight ends coach Steve Casula will serve as interim offensive coordinator for the game.U.S. authorities have confirmed the recent death of Suchir Balaji, a former OpenAI researcher who publicly criticized the company and was involved in a high-profile copyright lawsuit against it. Balaji, 26, was found dead in his San Francisco apartment on November 26, after police responded to a call at 1:00 PM. The San Francisco Police Department and the County Coroner’s Office ruled the death as suicide, stating there was "no suspicion of foul play." 3 View gallery Suchir Balaji ( Photo: Social media ) Balaji was a key figure in a lawsuit filed by major media organizations, led by The New York Times, against OpenAI. He was one of around 12 witnesses, most of whom were current or former OpenAI employees, summoned to testify in court. Just two weeks before his death, The New York Times’ legal team submitted a federal court document asserting that Balaji held "unique and highly relevant documents central to the case." His death comes three months after he publicly accused OpenAI of breaching U.S. copyright laws during the development of ChatGPT, the generative AI chatbot that has become a global phenomenon, serving hundreds of millions of users in just two years. Did OpenAI violate copyright laws? The launch of ChatGPT in late 2022 was not without controversy, sparking a wave of ongoing lawsuits. Writers, journalists, media organizations, and developers accused OpenAI of unlawfully using copyrighted materials to train its models, allegedly inflating its valuation to over $150 billion. In an interview with The New York Times last October, Balaji expressed concerns about OpenAI’s practices, claiming they harmed businesses and entrepreneurs whose data was used to train ChatGPT. "When you believe in what I believe in, you simply have to leave the company," he said. "This is not a sustainable model for the entire internet ecosystem." 3 View gallery ( Photo: Dado Ruvic / Reuters ) Balaji, who grew up in Cupertino and studied computer science at Berkeley, initially supported AI’s transformative potential, envisioning its ability to cure diseases and reverse aging. "I thought we could create a scientist to help solve these problems," he told The New York Times. However, his perspective shifted in 2022, two years after joining OpenAI, when he was tasked with gathering internet data to train GPT-4. He later expressed concerns that the task exceeded the boundaries of "fair use" laws in the U.S. "It went beyond what was legally permissible," he said in an interview. Following the interview, Balaji took to the social platform X (formerly Twitter) and shared his thoughts: "I worked at OpenAI for nearly four years, and for the last 1.5 years, I worked on ChatGPT. Initially, I didn’t know much about copyright laws or fair use, but I became interested after seeing all the lawsuits against generative AI companies. "As I dove deeper, I concluded that ‘fair use’ looks like a fragile defense for many generative AI products, especially since they can create substitutes that directly compete with the datasets they were trained on. Of course, I’m no lawyer, but I feel it’s important for non-lawyers to understand the law—not just its text, but also the reasoning behind it." "Copying content and undermining business models" Generative AI systems like ChatGPT operate by analyzing massive datasets scraped from the internet, using this information to generate user-driven outputs such as text, images, or videos. 3 View gallery GPT-4o announcement ( Photo: Youtube screenshot ) The release of ChatGPT accelerated the AI industry, prompting major tech companies to scramble to develop competing AI technologies, products, and features. Over the past year, OpenAI’s valuation has nearly doubled. Get the Ynetnews app on your smartphone: Google Play : https://bit.ly/4eJ37pE | Apple App Store : https://bit.ly/3ZL7iNv Meanwhile, media organizations have alleged that OpenAI, along with its business partner Microsoft (also a defendant in the New York Times lawsuit), copied content and damaged their business models. "They simply take the hard work of journalists, editors, and media professionals and use it—without regard for the efforts or legal rights of those who create the news that local communities rely on," one lawsuit claimed. OpenAI has denied these accusations, maintaining that its operations comply with "fair use" standards. "We see tremendous potential in tools like ChatGPT to deepen the connection between readers and publishers and to enhance the news consumption experience," the company stated in response to the lawsuit. >

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