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quick hit slots NoneStocks were choppy Tuesday as investors looked ahead to this week's key events on the economic calendar , which include a Wednesday afternoon appearance from Federal Reserve Chair Jerome Powell and the Friday morning release of the November jobs report. The Dow Jones Industrial Average finished the day down 0.2% at 44,705. However, the S&P 500 (+0.05% at 6,049.88) and the Nasdaq Composite (0.4% at 19,480) held on for a win, with both notching new record closing highs. Wall Street kept a cautious eye on global markets, though developments overseas did little to move the needle here at home. Most notably, South Korea's president, Yoon Suk Yeoul, declared martial law early Tuesday in order to eradicate "pro-North Korean forces." However, the country's parliament quickly – and unanimously – voted to end the order and President Yoon eventually agreed. Subscribe to Kiplinger’s Personal Finance Be a smarter, better informed investor. Sign up for Kiplinger’s Free E-Newsletters Profit and prosper with the best of expert advice on investing, taxes, retirement, personal finance and more - straight to your e-mail. Profit and prosper with the best of expert advice - straight to your e-mail. Job openings, quits were higher in October In economic news, the Bureau of Labor Statistics said this morning that job openings rose to 7.7 million in October from 7.4 million in September. Professional and business services saw the largest increases (+209,000), while the federal government saw the biggest decline (-26,000). The Job Openings and Labor Turnover Survey (JOLTS) release also showed that hires fell to 5.3 million from 5.6 million the month prior. Total separations edged up to 5.3 million from 5.2 million as quits rose 2.1%. "The labor market continues to look cooler, but not in trouble," says Elizabeth Renter , senior economist at NerdWallet. "Despite some month-to-month volatility, the number of job openings and hires continue to trend downward. This is happening at the same time as a low rate of layoffs." The job openings data hits just ahead of the Labor Department's monthly nonfarm payrolls report, which is due Friday morning. Shruti Mishra , an economist at BofA Securities, expects the report to show the U.S. added 240,000 new jobs in November – a sharp rebound from October's addition of just 12,000 jobs. "This above-consensus forecast is driven by expected payback for the temporary drag on payrolls in October due to Hurricane Milton and the Boeing ( BA ) strike," Mishra writes in a note to clients. However, the economist notes that a strong November jobs report "is unlikely to derail" a rate cut by the Fed at its December meeting, "but an upside surprise in November inflation could do the trick." According to CME Group's FedWatch Tool , futures traders are currently pricing in a 74% chance the Fed will cut interest rates by a quarter-percentage point at its meeting later this month – up from 62% yesterday. AT&T makes shareholder-friendly promises In single-stock news, AT&T ( T ) continued its red-hot run, rising 4.6% to bring its year-to-date gain to 40%. The telecom is headed toward its best calendar-year performance since 2019 and this latest surge comes courtesy of the company's shareholder-friendly initiatives. Specifically, at its annual Analyst & Investor Day, AT&T said it expects to accumulate at least $50 billion in free cash flow over the next three years, $40 billion of which will be returned to shareholders through dividends and stock buybacks . "Under this capital return plan, the Company expects to maintain its current annualized common stock dividend of $1.11 per share," AT&T said in a press release . "This plan would result in $20 billion+ in total dividend payments, with capacity for about $20 billion in share repurchases, from 2025-2027." Credo stock soars after earnings Credo Technology Group ( CRDO ) was another big winner, surging 47.9% after the maker of high-speed connectivity solutions for artificial intelligence (AI) data centers reported its fiscal second-quarter results. For the three months ended November 2, the company disclosed earnings of 7 cents per share on revenue of $72 million, beating analysts' expectations. Credo also forecast fiscal third-quarter revenue of $115 million to $125 million, with the midpoint of this range exceeding Wall Street's outlook for $120 million. "For the past few quarters, we have anticipated an inflection point in our revenue during the second half of fiscal 2025," said Credo Technology CEO Bill Brennan in the earnings release . "I am pleased to share that this turning point has arrived, and we are experiencing even greater demand than initially projected, driven by AI deployments and deepening customer relationships." Related content The Best Retail Stocks to Buy This Holiday Season Roth IRA vs. Traditional IRA: Which is Better? What Is an Index Fund and Should I Invest in One?

NoneTreysen Eaglestaff scores 19 as North Dakota cruises past Waldorf College 97-57BERWYN, Pa.--(BUSINESS WIRE)--Nov 21, 2024-- Virpax Pharmaceuticals, Inc. (Nasdaq: VRPX) (“Virpax” or the “Company”) , a company specializing in developing pharmaceutical products for pain management, announced that it has been granted an extension of its cooperative research and development agreement with the National Center for Advancing Translational Sciences (NCATS), an institute/center of the National Institutes of Health (NIH), U.S. Department of Health and Human Services. This collaboration is for the continued development of Virpax’s product candidate, NES100, an intranasal peptide, for the management of acute and chronic non-cancer pain. NES100 is an enkephalin drug product based on a type of nanotechnology delivery approach. Enkephalin is a naturally occurring (endogenous) peptide that is not easily administered in its original form. We believe that the nanotechnology may enable and enhance the delivery of this metabolically labile peptide drug into the brain. NES100 is the first investigational product formulation delivered via the nasal route with the potential to enhance enkephalin transport to the brain. NES100 uses a preassembled device and cartridge to propel the enkephalin formulation through the nose to the brain by flowing along the olfactory nerve pathway. The Molecular Envelope Technology (MET) is designed to protect and help carry the drug to the brain with the goal of promptly suppressing pain by binding to the delta opioid receptors. NES100 has demonstrated analgesic potential in animal models without the development of opioid tolerance, withdrawal, respiratory depression, euphoria, or addiction associated with use of opioids. Jatinder Dhaliwal, Chief Executive Officer of Virpax, commented, "We are excited that this collaboration has been extended with NCATS and the NIH Helping to End Addiction Long-term (HEAL) initiative as we believe that it may help Virpax develop an effective and safe alternative to conventional opioids used by patients to manage acute and chronic pain. We believe that the NIH/NCATS collaborative agreement will enable our team to maintain momentum in both our pre-clinical and clinical development strategies." About Virpax Pharmaceuticals Virpax is developing branded, non-addictive pain management products candidates using its proprietary technologies to optimize and target drug delivery. Virpax is initially seeking FDA approval for two prescription drug candidates that employ two different patented drug delivery platforms. ProbudurTM is a single injection liposomal bupivacaine formulation being developed to manage post-operative pain and EnveltaTM is an intranasal molecular envelope enkephalin formulation being developed to manage acute and chronic pain, including pain associated with cancer. Virpax is also using its intranasal Molecular Envelope Technology (MET) to develop one other prescription product candidate, NobrXiolTM, which is being developed for the nasal delivery of a pharmaceutical-grade cannabidiol (CBD) for the management of rare pediatric epilepsy. Virpax has competitive cooperative research and development agreements (CRADAs) for two of its prescription drug candidates, one with the National Institutes of Health (NIH) and one with the Department of Defense (DOD). Virpax is also seeking partners for two nonprescription product candidates: AnQlar, which is being developed to inhibit viral replication caused by influenza or SARS-CoV-2, and EpoladermTM, which is a topical diclofenac spray film formulation being developed to manage pain associated with osteoarthritis. For more information, please visit https://www.virpaxpharma.com .and follow us on Twitter, LinkedIn and YouTube. Forward-Looking Statements This press release contains certain forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995, as amended, including those described below. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management’s current beliefs and assumptions. These statements may be identified by the use of forward-looking expressions, including, but not limited to, “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “potential,” “predict,” “project,” “should,” “would” and similar expressions and the negatives of those terms. These statements relate to future events and involve known and unknown risks, uncertainties, and other factors, including the additional capital which will be necessary to complete studies and clinical trials that the Company plans to initiate and other factors listed under “Risk Factors” in the Company’s Annual Report on Form 10-K and Quarterly Reports on Form 10-Q that the Company has filed with the U.S. Securities and Exchange Commission. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. View source version on businesswire.com : https://www.businesswire.com/news/home/20241121242163/en/ CONTACT: Investor Contact: info@virpaxpharma.com KEYWORD: PENNSYLVANIA UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: BIOTECHNOLOGY MEDICAL DEVICES HEALTH PHARMACEUTICAL MEDICAL SUPPLIES SOURCE: Virpax Pharmaceuticals, Inc. Copyright Business Wire 2024. PUB: 11/21/2024 04:05 PM/DISC: 11/21/2024 04:06 PM http://www.businesswire.com/news/home/20241121242163/en

Saudi Gazette report RIYADH — Saudi Arabia will host the 28th Annual World Investment Conference (WIC) from November 25 to 27, 2024, under the patronage of Crown Prince Mohammed bin Salman. Organized by the Invest in Saudi platform in partnership with the World Association of Investment Promotion Agencies (WAIPA), the conference will spotlight digital transformation, sustainable growth, and expanding investment opportunities. Minister of Investment Eng. Khalid Al-Falih emphasized Saudi Arabia’s rise as a premier investment destination under the Vision 2030 framework, citing unprecedented growth in the volume and diversity of investments. “Hosting the WIC in Riyadh provides Saudi Arabia an opportunity to showcase its strategic vision to global partners and highlight its position as a reliable partner for investment and sustainable economic growth,” Al-Falih said. He noted that Vision 2030 has led to groundbreaking reforms, including issuing over 28,900 foreign investment licenses and allowing 100% foreign ownership in specific sectors. The simplification of commercial registration processes and visa issuance has created a welcoming climate for investors in areas such as renewable energy, logistics services, and artificial intelligence. The WIC will feature high-level ministerial dialogues, sessions on technology, sustainability, and economic cooperation, as well as expert-led workshops for investment professionals. The conference will include an entrepreneurship track to highlight the transformative role of startups and innovators, with exclusive networking sessions designed to foster strategic partnerships between investors, SMEs, and other stakeholders. The conference will cover critical topics such as the impact of artificial intelligence, resilience in global supply chains, energy transitions, and the role of startups in reshaping economies. It aims to promote ambitious investment models and drive global collaboration. < Previous Page Next Page >

Pakistani police arrest thousands of Imran Khan supporters ahead of rally in the capital

Van Nistelrooy has replaced Steve Cooper at the King Power Stadium and saw Jamie Vardy open the scoring after just 98 seconds. Bilal El Khannouss and Patson Daka added goals after the break to ensure the Dutchman started with three points in style. His task is to keep the Foxes in the Premier League this season and after ending a five-game winless run they moved up to 15th, four points clear of the relegation zone. West Ham’s hierarchy will have seen what impact a managerial change can have as the jury remains out on Lopetegui, with away fans making their feelings clear by chanting “You’re getting sacked in the morning”. Niclas Fullkrug scored a consolation goal at the death but it counted for nothing and forthcoming games against Wolves, Bournemouth, Brighton and Southampton could determine the Spaniard’s future. When Van Nistelrooy went to bed last night, even he would not have dreamt of his side starting as well as they did as they went ahead with less than two minutes on the clock. One of the Dutchman’s first conversations following his appointment was to take Vardy to task for breaking his record for scoring in the most consecutive Premier League games nine years ago. And the veteran striker rolled back to the years as, living on the shoulder of the West Ham defence, he raced clear from El Khannouss’ through-ball and slotted into the corner. The linesman’s flag immediately went up but a lengthy VAR review ruled Vardy had timed his run perfectly and the goal stood. Vardy could have added a second from a similar move but this time Lukasz Fabianski denied him. The Dutchman quickly learned about the frailties of his side as West Ham created a raft of chances in search of an equaliser. Jarrod Bowen forced Mads Hermansen into a stretching save when he cut in from the right before Ings’ header crashed into the post and Max Kilman slipped at the crucial point from the rebound. Bowen, a constant threat, sent a ball across face of goal which evaded everyone before the England international was denied by a reflex save from the busy Hermansen. The Danish goalkeeper needed to be alert to tip over Mohammed Kudus’ deflected effort early in the second half before he was saved by the referee’s whistle after after his attempted punch went into his own goal, Tomas Soucek the man penalised. Leicester remained a threat on the counter-attack and that is how they doubled their lead just after the hour. Kasey McAteer was set clear down the left and his ball inside was perfect for El Khannouss to find the bottom corner from 15 yards. It was almost three as Fabianski produced an acrobatic save from Wilfred Ndidi’s header before Leicester needed a heroic piece of defending to keep their 2-0 lead intact. Crysencio Summerville bundled the ball goalwards and it was heading over the line until Conor Coady adjusted his feet and poked it clear. The Foxes, who also had a goal from substitute Bobby De Cordova-Reid chalked off by VAR, wrapped things up in the 90th minute when Daka broke clear and emphatically converted into the roof of the net. West Ham did get on the scoresheet when Fullkrug headed a corner home, but the game was already done.I'm A Celebrity's most brutal Bushtucker trials - from eating live insects to 'drowning' in tubesChurch of Scientology Food Drive Makes Thanksgiving Special for 300 Local Families

MADRID (AP) — Getafe scored twice in three minutes midway through the second half to beat struggling Valladolid 2-0 and record only its second win in La Liga on Friday. The victory ended Getafe’s five-game winless run and lifted it into 15th place in the 20-team standings. Valladolid remained second to last. In the buildup to the match, Getafe sporting director Rubén Reyes described the game as a final but his team was lucky not to go behind as Valladolid created more of the early chances. However, the home side took control in the 69th minute when substitute Álvaro Rodríguez got the opener. Three minutes later, man of the match Allan Nyom made it 2-0. “There’s been a lot of games where we’ve run and fought but lost or drawn,” Nyom, the veteran Cameroon full back, said. “A game that reflects the effort we’ve put in in training is very welcome.” Adding to Valladolid’s woes, coach Paulo Pezzolano was sent off before halftime. The Uruguayan has the league’s worst disciplinary record, with seven yellow cards before Friday’s red. AP soccer:Ruben Amorim's Manchester United press conference: FIVE THINGS WE LEARNED as Portuguese coach fronted the media for the first time as Old Trafford boss Ruben Amorim dazzled in his latest round of press commitments at Man United While he is charismatic, he proved that he is going to be far from a soft touch Will Ruben Amorim be Man United's saviour? LISTEN NOW: It's All Kicking Off! Available wherever you get your podcasts. Episodes every Monday and Thursday By NATHAN SALT Published: 23:00, 22 November 2024 | Updated: 23:00, 22 November 2024 e-mail 2 View comments Ruben Amorim sat down to face the media for the first time since becoming Manchester United head coach. It was a fascinating 45 minutes in his company in which, speaking both English and Portuguese, he addressed topics on his style, why he believes in these players, and whether he has spoken to his idol, and former Manchester United manager, Jose Mourinho . Amorim smiled a lot but also showed there is a steeliness to his character, too. He is preparing to take charge of his first game in his new role on Sunday away to Ipswich Town where fans will watch with interest to see what he has managed to implement on these players in such a short space of time. As well as his briefing with reporters, he also sat down with former Manchester United defender Gary Neville for an extended chat for Sky Sports. Mail Sport picks out five things we learned from those two media appearances from the charismatic new man in charge... Ruben Amorim addressed the British media for the first time as Manchester United boss He was charismatic and insightful but also showed a steely side to him as a born winner DON'T BE FOOLED BY THE SMILE Amorim has a signature smile, that's the first thing to note. It is infectious to those who come into contact with him - but you would be wrong to assume his happy-go-lucky appearance at times paints him as a soft touch. Amorim is fiercely competitive and also incredibly clear in his demands. He said that having been a top-level player previously, he knows 'all of the tricks' and won't be giving players too much leeway to play with him or his coaches when it comes to putting in the hard yards. 'First thing, I think we have to be better athletes. That is something that you can acknowledge when we are here and we see the data,' he told Neville in the Sky Sports chat. 'When I say fitter, it's not being thinner or anything about that. It's the data. You have to understand the data to press high, what is the average metres that you have to run, the sprints. 'You have all this data and you have to cope with that. So you already know your goal is to reach that. You can run a lot but if you don't understand the game, it doesn't matter. But the first point to press high, you have to be very fit and you have to cope with the demands of pressing high.' So his non-negotiables, we learned what those are, too. 'You can say the pretty things like hard work, be professional. You should be,' he said. 'This is Manchester United. In every club [you should be] but here, of course, you cannot run from that. While he has a signature smile, there is also a ruthless drive that will rub off on his players More than 50 reporters were packed into the room at Carrington to hear Amorim speak 'The aim is to think first in the team. So I know that some guys will sometimes play in a different position, but they have to understand the position and they have to fight for the team. As a former player, I know every trick.' It should be noted, though, that at 39 years old and not too far removed from the dressing room as a player himself, Amorim can connect with many of United's stars like those who have come before him often couldn't. He knows how they think, knows how they operate on good and bad days and there is also that unwavering loyalty to his players. 'I can lose my job before throwing a player under the bus,' he said. 'But if he doesn't put the team in first place, I will be the first one to talk with the player.' To any of the players who were dialled in, consider the lines drawn in the sand. Now it's over to you. FULL-BACKS, NOT WINGERS, FOR WING-BACK ROLES Ever since Amorim got the job and it became clear he was going to go with 3-4-3 from the off, the identity of who will play in the wing-back roles has been the source of fierce debate. Wingers are synonymous with Manchester United but many of their attackers who play out wide have shown limited capabilities going the other way when asked to defend. He will favour full-backs such as Noussair Mazraoui (left) to play in his wing-back positions He is totally confident in his approach and philosophy but knows some players cannot do it It made Amorim's response to Neville when asked about it particularly interesting as an insight into his thinking after just a few days of training. He said he will 'likely start with full backs in wing-back roles, because to teach a winger to defend is harder.' It should be noted that in training footage released by United we saw Antony deployed as a right wing-back. Read More Man United boss Ruben Amorim reveals message from Jose Mourinho as he insists job ISN'T impossible But if we take Amorim at his word now, it means that Bruno Fernandes, Marcus Rashford, Alejandro Garnacho, Amad Diallo, Mason Mount, Joshua Zirkzee and Rasmus Hojlund are all competing for just three places in the 3-4-3 line up, with Diogo Dalot and Noussair Mazraoui set to get the nods out wide. It was also particularly interesting in his press conference that Amorim has total belief in his system and any players who don't feel the same will soon be cut loose. 'As a coach you have to choose one way or another, I choose always 100 per cent our way,' he said. 'I choose to risk a bit. I believe so much in our way of playing; they will believe too. There is no second way. 'We will adapt some players because we don't have a different profile. Maybe on Sunday you will see the starting 11 and not feel a lot of change but you will see it in the game and the positioning or where they receive the ball.' Garnacho the left wing-back? Think again. It raises questions about where Alejandro Garnacho fits in with a system not suited to wingers HE CAN HANDLE THE PRESSURE - AND MANAGEMENT 'Call me naive,' he said with a grin on his face, 'but I truly believe that I'm the right guy in the right moment. 'I could be wrong, but the earth still will turn, the sun will rise again. It doesn't matter. I truly believe that I'm the right guy for this job.' This wasn't bluster. A man bluffing his way to a headline. Ruben Amorim has total belief that he is the man to finally take Manchester United back to the top. Now, they all say this during the honeymoon stage, you expect nothing less. And perhaps this is recency bias but observing Amorim it is hard not to be impressed - and ultimately believe him. It is important to note too that he is not scared to tread where perhaps other new managers dare not, particularly when it comes to calling out his superiors. 'Us as a club have to set the standards and have to manage that,' he told Neville when asked about Marcus Rashford and Casemiro jetting off to the United States during the international break. 'It's my decision if they can have five days, or three days, or three days to rest and you cannot fly. This is something that us as a club have to decide. 'Would I set a different structure? Yes, for sure.' Amorim transformed Sporting into the dominant force in Portuguese football and he didn't take them there by worrying about who he may upset along the way. His career to date has built him up for the biggest challenge of them all, now it's on him to show he can handle it and thrive, rather than shrink, in the spotlight. Amorim thinks he can be first United boss to win the Premier League since Sir Alex Ferguson Amorim appears intent on learning about the history of the club He must now figure out how to get the best out of the current United squad RUBEN'S CRUCIAL VETO Erik ten Hag used to talk about being 'in the same boat' with Ineos and the football board, particularly when it came to recruitment. We reported recently that funds will be significantly reduced for Amorim as a result of Ten Hag's lavish spend of more than £600million - but we learned that any suggestion he won't be consulted, or allowed a veto, on signings is flat out wrong. 'I think it has to be all together because if you are a coach coming here and already chose the players, you could be wrong because the club will be here for a long time and you as a coach, you don't know that,' he said. 'We have to improve the process of recruitment, the data. I think it is all together, but the final word should be the manager, not because it is your right but because it is your responsibility. 'I have to understand the league and then when everything is aligned, everyone is on the same page, we can buy and sell players.' Sporting director Dan Ashworth and technical director Jason Wilcox have been key drivers in recruitment since arriving but consider this another line drawn in the sand by Amorim. It is he who will have the final say, that much is for sure. Amorim (pictured far right) will have to work with Man United's INEOS board on recruitment GET YOUR RUNNING SHOES, LADS! Footage from his early training sessions showed him getting his players rushing up and down the pitch to recover possession in the exercise of giving it away. They do that a lot in games, he conceded, and continuing to do that will see results falter as they have been. So, along with needing to be ‘better athletes’ you can bet your bottom dollar that Amorim and his coaching staff will be relentless when it comes to the fitness levels of this group between now and the end of the season. I hope the players packed their running shoes... Marcus Rashford Ruben Amorim Gary Neville Share or comment on this article: Ruben Amorim's Manchester United press conference: FIVE THINGS WE LEARNED as Portuguese coach fronted the media for the first time as Old Trafford boss e-mail Add comment

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