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Sipavibart is a monoclonal antibody commercialized by , with a leading Phase III program in Coronavirus Disease 2019 (COVID-19). According to Globaldata, it is involved in 6 clinical trials, of which 2 were completed, 3 are ongoing, and 1 is planned. Smarter leaders trust GlobalData The gold standard of business intelligence. The revenue for Sipavibart is expected to reach an annual total of $28 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. Sipavibart Overview AZD-3152 is under development for the treatment of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It acts by targeting spike protein of SARS-CoV-2. The drug candidate is an investigational next-generation long-acting antibody (LAAB) and administered through intravenous and intramuscular routes. AstraZeneca Overview is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The company operates in Europe, the Americas, Asia, Africa and Australasia. is headquartered in Cambridge, Cambridgeshire, the UK. The company reported revenues of (US Dollars) US$45,811 million for the fiscal year ended December 2023 (FY2023), an increase of 3.3% over FY2022. In FY2023, the company’s operating margin was 17.9%, compared to an operating margin of 8.5% in FY2022. In FY2023, the company recorded a net margin of 13%, compared to a net margin of 7.4% in FY2022. The company reported revenues of US$12,938 million for the second quarter ended June 2024, an increase of 2% over the previous quarter. For a complete picture of Sipavibart’s valuation, From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company. The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s .A late-game rally derailed by a missed extra point and Cowboys stun Commanders 34-26
Indiana State finished out its season Saturday afternoon with a 41-34 Missouri Valley Football Conference loss to Northern Iowa inside the UNI-Dome at Cedar Falls, Iowa. The Sycamores got off to a fast start as quarterback Elijah Owens rushed 4 yards for an early touchdown with Ryan O'Grady converting the extra point to make it 7-0. But the Panthers' Jaden Palmer converted a 39-yard field goal midway through the first quarter to pull within 7-3. Before the first period ended, the Panthers grabbed the lead at 10-7 on a 63-yard punt return by Sergio Morancy. ISU responded with Owens running for another TD, this time covering 2 yards. UNI regained the lead, however, when Morancy received a 24-yard TD pass from Aidan Dunne to make it 17-14. The gap was widened after the home team stripped the ball from ISU. Morancy then hauled in another pass and took it to the end zone for a 69-yard score with 7:47 left in the first half to make it 24-14. ISU cut its deficit to 24-17 on a 26-yard field goal by O'Grady on the last play of the first half. Northern Iowa's Tye Edwards rushed 75 yards to the end zone to make it 31-17 at the 14:07 mark of the third frame. Edwards exploded again for another huge gain before he was brought down. Palmer soon converted a 19-yard field goal to extend the advantage to 34-17 midway through the third quarter. The visitors chipped into their deficit when Kevin Barnett received a pass from Owens for a 73-yard touchdown to pull within 34-24. ISU got off to another fast start in the fourth quarter when Shen Butler-Lawson hauled it 68 yards to the end zone to slice its deficit to 34-31 at the 14:06 mark. But the Panthers were able to widen the gap again when Morancy received a 13-yard touchdown pass with 7:44 left to make it 41-31. The Sycamores found themselves close to the end zone but botched the snap and had to go chasing after the ball, which left them further back on the field. With that, they had to settle for an O'Grady field goal from 27 yards out with 3:37 showing on the scorebook and that ended the scoring. Statistical highlights for Indiana State included 135 and 125 yards rushing for Owens and Butler-Lawson respectively. For UNI, Edwards gained 235 yards on the ground. The Sycamores finished 5-7 overall and 3-5 in the MVFC. Afterward, ISU coach Curt Mallory talked highly of the seniors on this season's team and the leadership they brought. "I'm awfully proud of these seniors," Mallory said via email. "They've led this team to the very end, the end of the season, end of each game. ... It's a special group and we have to build off of that. "Great leadership from them. It was a tough loss today, but awfully proud of this team and how they fought together all year." He offered high praise for the offensive players, but noted they needed to capitalize on some plays and acknowledged how the team gave up big plays on special teams and defense. "The one thing we have done is we've fought all year long," Mallory emphasized. Going into the offseason, Mallory said they want to build off this season. Improvement was significant for the Sycamores, who went from one win last season to four this season. He said they got a taste of victory and that the guys know how close they are with how close they were in a lot of games. Mallory said they have to work even harder over the offseason so they can get the close ones at the end. Indiana State 7 10 7 10 — 34 Northern Iowa 10 14 10 7 — 41 ISU — Owens 4 run (O'Grady kick), 10:49 1Q UNI — FG Palmer 39, 7:16 1Q UNI — Morancy 63 run (Palmer kick), 5:55 1Q ISU — Owens 2 run (O'Grady kick), 14:22 2Q UNI — Morancy 24 pass from Dunne (Palmer kick), 11:06 2Q UNI — Morancy 69 pass from Dunne (Palmer kick), 7:47 2Q ISU — FG O'Grady 26, 0:00 2Q UNI — Edwards 75 run (Palmer kick), 14:07 3Q UNI — FG Palmer 19, 6:26 3Q ISU — Barnett 73 pass from Owens (O'Grady kick), 4:58 3Q ISU — Butler-Lawson 68 run (O'Grady kick), 14:06 4Q UNI — Morancy 13 pass from Dunne (Palmer kick), 7:44 4Q ISU — FG O'Grady 27, 3:37 4Q ISU UNI First downs 20 18 Rushes-yards 273 225 Passing-yards 206 204 Comp-Att-Int 16-22-0 13-15-0 Return yards 78 120 Fumbles-lost 2-1 0-0 Punts-avg 3-43.7 0-0 Penalties-yards 10-110 7-55 Individual statistics Rushing — Indiana State, Owens 20-135, Butler-Lawson 17-125, Allen 4-39, Lawrence 1-3. Northern Iowa, Edwards 22-235, Dunne 4-12, Pesek-Hickson 5-6, Morancy 1-0. Passing — Indiana State, Owens 14-20-0 168, Rochelle 1-1-0 24, Traum 1-1-0 14. Northern Iowa, Dunne 13-15-0 204. Receiving — Indiana State, Taylor 4-32, Chambers 3-45, Rochelle 3-10, Butler-Lawson 2-20, Barnett 1-73, Shew 1-14, Allen 1-8, Ciocca 1-4. Northern Iowa, Morancy 5-119, Hutson 3-20, Pryor 2-24, Kershaw 1-19, Edwards 1-14, McCullough 1-8.
A bankruptcy judge on Monday delayed a hearing in conspiracy theorist Alex Jones’ effort to stop the satirical news outlet The Onion from buying Infowars, keeping the auction sale up in the air for at least another few weeks. Jones alleges fraud and collusion marred the bankruptcy auction that resulted in The Onion being named the winning bidder over a company affiliated with him. A trustee overseeing the auction denies the allegations and accuses Jones of launching a smear campaign because he didn't like the outcome. U.S. Bankruptcy Judge Christopher Lopez had been scheduled to hear an emergency motion to disqualify The Onion's bid on Monday, but put it off until either Dec. 9 or Dec. 17. That's also when the judge will hear arguments on the trustee's request to approve the sale of Infowars to The Onion. Lopez said it made sense to have one hearing on both requests. “I want a fair and transparent process and let’s just see where the process goes," Lopez said. Lopez could ultimately allow The Onion to move forward with its purchase, order a new auction or name the other bidder as the winner. At stake is whether Jones gets to stay at Infowars’ studio in Austin, Texas, under a new owner friendly to him, or whether he gets kicked out by The Onion. The other bidder, First United American Companies, runs a website in Jones’ name that sells nutritional supplements. Jones continues to broadcast his show from the Infowars studio, but he has set up a new location, websites and social media accounts as a precaution. The trustee shut down the Austin studio and Infowars' websites for about 24 hours last week after The Onion was announced as the winning bidder, but allowed them to resume the next day, drawing more complaints from Jones. Jones declared bankruptcy and liquidated his assets after he was ordered to pay nearly $1.5 billion to relatives of victims of the Sandy Hook Elementary School shooting in Newtown, Connecticut. He was ordered to pay damages for defamation and emotional distress in lawsuits in Connecticut and Texas after he repeatedly said the 2012 shooting that killed 20 first graders and six educators was a hoax staged by actors to increase gun control. Proceeds from the liquidation are to go to Jones’ creditors, including the Sandy Hook families who sued him. Last year, Lopez ruled that $1.1 billion of the Sandy Hook judgments could not be discharged in the bankruptcy. On Monday, he denied a request from Sandy Hook families to make the full $1.5 billion not dischargeable, meaning the debt cannot be wiped clean. Also Monday, lawyers for the social media platform X objected to any sale of the accounts of both Jones and Infowars, saying X is the owner of the accounts and it has not given consent for them to be sold or transferred. Jones' personal X account, with 3.3 million followers, was not part of the auction, but Lopez will be deciding if it should be included in the liquidation. Jones has praised X owner Elon Musk on his show and suggested that Musk should buy Infowars. Musk has not responded publicly to that suggestion and was not among the bidders. Jones was permanently banned from Twitter in 2018 for abusive behavior, but Musk restored Jones’ account on the platform he has since renamed X in December last year. Jones alleges The Onion’s bid was the result of fraud and collusion involving many of the Sandy Hook families, the humor site and the court-appointed trustee. First United American Companies submitted a $3.5 million sealed bid, while The Onion offered $1.75 million in cash. But The Onion's bid also included a pledge by Sandy Hook families to forgo some or all of the auction proceeds due to them to give other creditors a total of $100,000 more than they would receive under other bids. The trustee, Christopher Murray, said that made The Onion's proposal better for creditors and he named it the winning bid. Jones and First United American Companies claimed that the bid violated Lopez’s rules for the auction by including multiple entities and lacking a valid dollar amount. Jones also alleged Murray improperly canceled an expected round of live bidding and only selected from among the two sealed bids that were submitted. Jones called the auction “rigged” and a “fraud” on his show, which airs on the Infowars website, radio stations and Jones' X account. He filed a counter lawsuit last week against Murray, The Onion's parent company and the Sandy Hook families in the bankruptcy court. In a court filing on Sunday, Murray called the allegations a “desperate attempt” to delay the sale of Infowars to The Onion and accused Jones, his lawyers and attorneys for First United American Companies of a “vicious smear campaign lobbing patently false accusations.” He also alleged Jones collaborated with First United American Companies to try to buy Infowars. Lopez’s September order on the auction procedures made a live bidding round optional. And it gave broad authority to Murray to conduct the sale, including the power to reject any bid, no matter how high, that was “contrary to the best interests” of Jones, his company and their creditors. The assets of Infowars' parent company, Free Speech Systems, that were up for sale included the Austin studio, Infowars' video archive, video production equipment, product trademarks, and Infowars' websites and social media accounts. Another auction of remaining assets is set for Dec. 10. Jones is appealing the $1.5 billion in judgments citing free speech rights, but has acknowledged that the school shooting happened . Many of Jones’ personal assets, including real estate, guns and other belongings, also are being sold as part of the bankruptcy. Documents filed in court this year say Jones had about $9 million in personal assets, while Free Speech Systems had about $6 million in cash and more than $1 million worth of inventory.ENGLEWOOD, Colo. (AP) — What's stoking the Denver Broncos' surprising surge is the growing connection between rookie quarterback Bo Nix and veteran wide receiver Courtland Sutton. Whenever the Broncos (7-5) need a clutch catch, a key flag or a timely touchdown, Sutton is usually the one delivering it like he did Sunday when he caught eight passes on 10 targets for 97 yards and a pair of touchdowns that sparked the Broncos' come-from-behind 29-19 win at Las Vegas. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Get updates and player profiles ahead of Friday's high school games, plus a recap Saturday with stories, photos, video Frequency: Seasonal Twice a weekHow to help military members and missionaries smoothly transition home
Dennis Corslake, from Mullion, joined Garador, a garage door manufacturer, in 1985. He wanted to reconnect with former colleagues who had regularly met at the company's head office in Yeovil and formed close friendships over the years. Mr Corslake said: "I joined Garador in 1985 and knew some of my ex-work colleagues all my working life. READ MORE: Waterfront village pub in Cornwall won't move Christmas tree Reunion held at Garador's Yeovil office (Image: Garador) "Now retired, we all live in very different parts of the country, but I heard that one of our former colleagues hadn't been very well, and I thought it was time we all renewed our friendships and had a get together." The company supported Mr Corslake's idea and organised a reunion lunch, bringing people together from across the UK. Mr Corslake said: "It was wonderful to have this chance to get together again, re-renew our friendships and to chat about the good old days. "Garador has always been a fantastic and caring company; they once helped me transfer up to Nottingham because my daughters were living there at the time and I wanted to be near them." He added: "For the reunion, they organised a lovely lunch for us and then took us on a full factory tour so that we could see the changes that have taken place since our day." The managing director of Garador, Jon Watson said he was pleased that the event was a success. Mr Watson said: "Garador is sometimes described as one big happy family, and certainly that was the atmosphere at this luncheon. "Our manufacturing processes and indeed our doors have changed dramatically since the days when most of them started, but clearly the friendships have stayed the same and that was lovely to see." Garador, recognised as Britain's leading garage door manufacturer, has a history dating back to the late 1940s. The company now operates from a state-of-the-art factory complex just outside Yeovil in Somerset and supplies the latest in garage doors and garage door technology to merchants, builders and developers right across the country. The reunion gave the former area sales managers a chance to see the changes that have occurred over the years at the company., /PRNewswire/ -- Representatives from and shared their insights on promoting artificial intelligence (AI) governance and data sharing at a sub-forum of the 20th Beijing-Tokyo Forum in recently. The sub-forum contributed eastern wisdom to AI governance and digital social development, demonstrating the significance of international cooperation for the development of the digital economy, according to Gao Shaolin, advisor at Peking University's Legal Artificial Intelligence Research Center. AI governance framework The participants agreed that the next 10 years will be a critical period for the development of AI. Gao Wen, academician of the Chinese Academy of Engineering (CAE), said since State Council issued a guideline on developing AI in 2017, the nation has made significant progress in AI research and development and industrial layout, especially in computing power and 5G network construction. By the end of 2023, had over half of the world's 1.57 billion 5G users, according to the World Internet Development Report 2024. It ranked second globally in AI and computing power scale, which has laid a solid foundation for the rapid development of AI. , project professor at the of Health and Welfare, said it was very meaningful for and to discuss strengthening AI governance rules. , research director of the Nomura Research Institute, echoed his view. He emphasized that the core goal of AI technology is to improve productivity and eliminate obstacles to social development, and called on Chinese and Japanese experts to work together to build an AI governance framework to cope with the global challenges. Deepening international cooperation put forth the Global AI Governance Initiative in October last year. In July, the UN General Assembly adopted a -sponsored resolution on enhancing international cooperation on AI capacity-building. The participants spoke highly of the Global Cross-Border Data Flow Cooperation Initiative recently proposed by . They agreed that AI governance requires global collaboration, especially in the formulation of international standards and the construction of ethical frameworks, where and can play an active role. Ding Wenhua, academician of the CAE, said and have both similarities and differences in technology development and governance priorities, so deepening cooperation will bring unique value to global AI governance. " and should deepen AI technology cooperation between enterprises, work together in AI security research, talent exchange, and jointly explore more possibilities for the application of technology," , president of the Beijing Academy of Artificial Intelligence, said. Balancing development & risks AI governance refers to the guardrails established to ensure AI systems and tools remain safe and ethical and respect human rights. , editor-in-chief of Science and Technology Daily, stressed that AI, as a revolutionary technology, has far-reaching impacts on all areas of society and economy. However, its potential risks such as data leakage and the spread of false information should not be ignored. "Technological progress and security ethics should be developed in a balanced way to ensure that AI technology always serves the progress of human civilization," Xu said. AI governance should not only heed the current technological ethics issues, but also prevent possible long-term risks, such as AI going out of human control, according to , senior corporate advisor of NTT DATA. He said AI R&D and application should abide by the principles of fairness, transparency, safety and availability. Yuan Yue, chairman of Beijing Dataway Horizon, shared his view from the perspective of regulatory models. "Policy choices should be based on the current status and goals of national technological development," Yuan said, adding that prefers to provide a more friendly development environment for enterprises while ensuring an effective response to risks. View original content to download multimedia: SOURCE Science and Technology Daily
Agomelatine is a small molecule commercialized by Alto Neuroscience, with a leading Phase II program in Major Depressive Disorder. According to Globaldata, it is involved in 3 clinical trials, of which 2 were completed, and 1 is ongoing. Smarter leaders trust GlobalData The gold standard of business intelligence. The revenue for Agomelatine is expected to reach an annual total of $104 mn by 2039 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. Agomelatine Overview Agomelatine (ALTO-300) is under development for the treatment of major depressive disorder (MDD). It is administered through oral route. It acts by targeting MT1, MT2 and 5-HT2C. It was also under development for post-traumatic stress disorder (PTSD). Alto Neuroscience Overview Alto Neuroscience is a biopharmaceutical company that develops drugs for psychiatric and mental health conditions. It is investigating ALTO-100, ALTO-202, and ALTO-300 drugs for the treatment of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) by targeting cognition, emotion, and sleep systems. The company utilizes its AI-enabled drug development platform that identifies biomarkers by evaluating brain function measures to develop its product candidates. It serves throughout the US. Alto Neuroscience is headquartered in Los Altos, California, the US. The operating loss of the company was US$37.8 million in FY2023, compared to an operating loss of US$29.2 million in FY2022. The net loss of the company was US$36.3 million in FY2023, compared to a net loss of US$27.7 million in FY2022. For a complete picture of Agomelatine’s valuation, From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company. The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s .
The holiday season is upon us, and what better way to celebrate than by gifting the latest and greatest in tech toys? Whether you're shopping for a tech-savvy teen, a gadget-loving friend, or even a young aspiring engineer, there’s a world of innovative toys to spark creativity, fun, and learning. In this round-up, we’ve curated some of the best Christmas tech toys that are sure to delight and inspire... GoChess Mini Price: £199.99 An AI-powered smart chess board with colour-coded coaching lights, and online connectivity through the dedicated app. GoChess Mini isn't just about playing the game; it's about improving skills, tracking progress, and connecting with other players. Offering three play modes, users can play GoChess Mini face-to-face with an opponent or alone in AI mode (with 32 levels of difficulty to choose from). Additionally, they can connect to popular chess platforms (Lichess and Chess.com) and play against people around the world or solve challenging puzzles and revisit historical games. Maxcom Kiddo Smartwatch RRP: £69.99 The 4G Kiddo smartwatch is designed for children while also offering additional safety features, including location tracking and remote camera/microphone activation. Exciting to children and practical to parents, it's an ideal alternative to a smartphone this Christmas . The watch is packed with exciting apps, including built-in games, calculator and alarm clock. The video calling function allows them to connect with you or friends in an instant, futuristic fashion. Gel Blaster SURGE Price: £59.99 (currently £34.99) An advanced blaster with no mess or clean-up technology, meaning you can battle indoors or outdoors.. It comes with 10,000 water-based Gellets which are non-toxic, non-staining, non-irritating and pet safe. Bursting on impact, they provide safe and mess-free fun. SURGE has two blast modes - Single Shot for honing your precision and training, and Fully Automatic for dominating the competition. GoCube Price: £59.99 The iconic Rubik’s cube reimagined, the GoCube is an app-enabled speed cube that allows anyone to learn how to solve the cube. This award-winning puzzle toy and dedicated app helps users to master the cube thanks to a fun and interactive step-by-step tutorial, tracking progress in real-time. Users can play and practise with multiple mini-games to choose from or battle with friends and other cubers online to get on the global leader board. Whether learning, improving, battling or playing, GoCube takes cubing to the next level. GoBalance Play Price: £79.99 The GoBalance Play, combined with its engaging and interactive games, makes exercising fun for the entire family. This smart wobble balance board, designed by physiotherapists, enhances motor skills, core strength, flexibility, coordination and concentration. Connecting to any Android or iOS device via Bluetooth, a free app offers interactive and challenging games such as snowboarding or mini golf, that make exercising enjoyable whilst helping to develop physical and mental abilities.I’m a Celeb fans blast Dean McCullough as he makes ‘cheeky’ request to Danny Jones
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Neuberger Berman Municipal Fund Inc. (NYSEAMERICAN:NBH) Shares Purchased by Avior Wealth Management LLCMadonna, the iconic pop star known for her provocative acts, has once again stirred the pot with her latest social media post, this time by sharing AI-generated images of herself with Pope Francis that many have deemed inappropriate and disrespectful. Madonna who has had tensions with the Catholic Church, posted the images on her Instagram Story; she shared AI-generated images featuring herself and Pope Francis in suggestive poses, igniting a wave of controversy and backlash from fans and critics alike. The images, created by an Instagram user named Rick Dick, depict Madonna in suggestive poses with the Pope, including one where he appears to have his arm around her waist and another where their faces are close together, seemingly intimate. Accompanying the images were captions such as "Feels good to be seen" and "Going into the weekend like..." Madonna faces backlash The backlash was swift, with many social media users expressing their outrage. Comments ranged from labeling the images as "creepy" and "disrespectful" to outright condemnation of the portrayal of the Pope in such a manner. One user remarked, "This is ridiculously disrespectful," while another added, "This is insanely disrespectful and weird, and I am not even Christian". Critics argue that the images not only trivialize the sanctity of the papacy but also reflect poorly on Madonna's artistic choices. Madonna's provocative tactics This incident is not the first time Madonna has faced backlash from the Catholic Church. Her history of provocative imagery dates back to her 1989 music video for "Like a Prayer," which was condemned by the Vatican for its blasphemous content. The controversy surrounding that video led to significant public outcry and even attempts by the Church to boycott her subsequent tour. Madonna has often defended her work, stating that her artistic expressions aim to provoke thought and discussion about spirituality and freedom of expression rather than to offend. Fans come to her support Despite the criticism, some fans have come to Madonna's defense, arguing that her humor and willingness to push boundaries make her an enduring figure in pop culture. Supporters have pointed out that the images were intended as a joke and reflect her unique sense of humor, with one fan stating, "What ‘fans’ are actually angry? We love her wicked sense of humor". 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Critics argue that using AI to depict a religious figure in such a manner is not only disrespectful but also reflects a troubling trend in digital art where boundaries are increasingly blurred. The ability of AI to generate provocative content can lead to ethical dilemmas, particularly when it involves figures of significant cultural and religious importance Neither Madonna nor the Vatican has publicly addressed the backlash surrounding the AI-generated images. (You can now subscribe to our Economic Times WhatsApp channel )
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