Allar puts critics on mute, keeps winning for Penn StateUnlike scores of people who for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It’s a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It’s all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person’s response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn’t happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It’s not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn’t respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I’m hoping it’s slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content. Jonel Aleccia, The Associated Press
A South Korean legislative push to impeach President Yoon Suk Yeol over his short-lived imposition of martial law fell through on Saturday after most lawmakers from his conservative governing party boycotted the vote. The defeat of the motion is expected to intensify public protests calling for Yoon's ouster and deepen political chaos in South Korea, with a survey suggesting a majority of South Koreans support the president's impeachment. Yoon's martial law declaration drew criticism from his own ruling conservative party, but it is also determined to oppose Yoon's impeachment apparently because it fears losing the presidency to liberals. Impeaching Yoon required support from two-thirds of the National Assembly, or 200 of its 300 members. The opposition parties who brought the impeachment motion had 192 seats, but only three lawmakers from PPP participated in the vote. The motion was scrapped without ballot counting because the number of votes didn't reach 200. National Assembly Speaker Woo Won Shik called the result "very regrettable" and an embarrassing moment for the country's democracy that has been closely watched by the world. "The failure to hold a qualified vote on this matter means we were not even able to exercise the democratic procedure of deciding on a critical national issue," he said. People take part in a protest calling for the ouster of the South Korean president outside the National Assembly in Seoul on Saturday. Nearly 150,000 people attended the rally, demanding Yoon Suk Yeol step down. (Anthony Wallace/AFP/Getty Images) Opposition parties could submit a new impeachment motion after a new parliamentary session opens next Wednesday. South Korea's main opposition Democratic Party said it would not give up its attempt to impeach Yoon. But Yoon's People Power Party said it would find a "more orderly, responsible" way to resolve the crisis than impeachment of the president. There are worries that Yoon won't be able to serve out his remaining 21⁄2 years in office because his leadership took a huge hit. Many experts say some ruling party lawmakers could eventually join opposition parties' efforts to impeach Yoon if public demands for it grow further. If Yoon is impeached, his powers will be suspended until the Constitutional Court decides whether to remove him from office. If he is removed, an election to replace him must take place within 60 days. Members repeatedly called to vote Woo repeatedly urged ruling party members to return to the chamber to participate in the vote, waiting several hours for them to come. At one point, Democratic Party leaders visited a hall on the floor below the main chamber where PPP lawmakers were gathered, attempting to persuade them to vote. After being blocked from entering, they angrily accused the conservatives' leadership of preventing its lawmakers from voting freely. Earlier Saturday, Yoon issued a public apology over the martial law decree, saying he won't shirk legal or political responsibility for the declaration and promising not to make another attempt to impose martial law. He said would leave it to his party to chart a course through the country's political turmoil, "including matters related to my term in office." South Korea's president apologizes to nation for declaring martial law South Korea ruling party opposes impeachment despite its leader's stunning comments about president "The declaration of this martial law was made out of my desperation. But in the course of its implementation, it caused anxiety and inconveniences to the public. I feel very sorry over that and truly apologize to the people who must have been shocked a lot," Yoon said. Since taking office in 2022, Yoon has struggled to push his agenda through an opposition-controlled parliament and grappled with low approval ratings amid scandals involving himself and his wife. In his martial law announcement on Tuesday night, Yoon called parliament a "den of criminals" bogging down state affairs and vowed to eliminate "shameless North Korea followers and anti-state forces." The turmoil resulting from Yoon's bizarre and poorly-thought-out stunt has paralyzed South Korean politics and sparked alarm among key diplomatic partners like the U.S. and Japan. Troops had encircled parliament building Tuesday night saw special forces troops encircling the parliament building and army helicopters hovering over it, but the military withdrew after the National Assembly unanimously voted to overturn the decree, forcing Yoon to lift it before daybreak Wednesday. The declaration of martial law was the first of its kind in more than 40 years in South Korea. Eighteen lawmakers from the ruling party voted to reject Yoon's martial law decree along with opposition lawmakers. Yoon's speech fuelled speculation that he and his party may push for a constitutional amendment to shorten his term, instead of accepting impeachment, as a way to ease public anger over the marital law and facilitate Yoon's early exit from office. WATCH | An end to Yoon's presidency? Aborted martial law in South Korea 'probably heralds the end of Yoon's presidency': analyst 4 days ago Duration 5:02 Jeremy Chan, senior analyst for China and Northeast Asia at Eurasia Group, says South Korean President's Yoon Suk Yeol's tenure is likely at risk after lawmakers including members of his own party unanimously rejected his declaration of martial law. Yoon's term was set to end in 2027, but he is likely to face direct impeachment articles in the coming weeks, Chan says. Lee Jae-myung, the leader of the main liberal opposition Democratic Party, told reporters that Yoon's speech was "greatly disappointing" and that the only way forward is his immediate resignation or impeachment. His party called Yoon's martial law "unconstitutional, illegal rebellion or coup." The passage of Yoon's impeachment motion appeared more likely Friday when the chair of Yoon's party called for his removal on Friday, but the party remained formally opposed to impeachment. On Saturday, tens of thousands of people densely packed several blocks of roads leading up to the National Assembly, waving banners, shouting slogans and dancing and singing along to K-pop songs with lyrics changed to call for Yoon's ouster. Protesters also gathered in front of PPP's headquarters near the Assembly, angrily shouting for its lawmakers to vote to impeach Yoon. Protesters take part in a demonstration against the president late Saturday in Seoul. President Yoon Suk Yeol has been under fire following his controversial declaration of martial law, which sparked widespread public outrage and political turmoil. (Chung Sung-Jun/Getty Images) A smaller crowd of Yoon's supporters, which still seemed to be in the thousands, rallied in separate streets in Seoul, decrying the impeachment attempt they saw as unconstitutional. Lawmakers on Saturday first voted on a bill appointing a special prosecutor to investigate stock price manipulation allegations surrounding Yoon's wife. Some lawmakers from Yoon's party were seen leaving the hall after that vote, triggering angry shouts from opposition lawmakers. On Friday, PPP chair Han Dong-hun, who criticized Yoon's martial law declaration, said he had received intelligence that during the brief period of martial law Yoon ordered the country's defence counterintelligence commander to arrest and detain unspecified key politicians based on accusations of "anti-state activities." South Korean opposition parties submit motion to impeach president over martial law order South Korea's defence minister resigns after failed martial law push Hong Jang-won, first deputy director of South Korea's National Intelligence Service, told lawmakers in a closed-door briefing Friday that Yoon had ordered him to help the defence counterintelligence unit to detain key politicians. The targeted politicians included Han, Lee and Woo, according to Kim Byung-kee, one of the lawmakers who attended the meeting. People at a railway station in Seoul gather to watch a live television address from South Korean President Yoon Suk Yeol on Saturday. The president apologized for causing a public stir by declaring martial law and promised there will not be a second martial law declaration. (Kim Soo-hyeon/Reuters) The Defence Ministry said Friday it suspended three military commanders including the head of the defence counterintelligence unit over their involvement in enforcing martial law. Vice-Defence Minister Kim Seon Ho has told parliament that Defence Minister Kim Yong Hyun ordered the deployment of troops to the National Assembly after Yoon imposed martial law. Opposition parties accused Kim of recommending to Yoon to enforce martial law. Kim resigned Thursday, and prosecutors imposed an overseas travel ban on him.
The five-year decline in earnings for Selective Insurance Group NASDAQ:SIGI) isn't encouraging, but shareholders are still up 61% over that periodPresident-elect Donald Trump asked the Supreme Court on Friday to delay a law that would effectively ban TikTok from taking effect until after he assumes office. Trump lawyer John Sauer, who is the solicitor general designee for the incoming administration, petitioned the high court to postpone its hearing on the TikTok ban, arguing that the matter could be redressed “through political means” instead. “President Trump alone possesses the consummate dealmaking expertise, the electoral mandate, and the political will to negotiate a resolution to save the platform while addressing the national security concerns,” Sauer wrote. “In light of these interests — including, most importantly, his overarching responsibility for the United States’ national security and foreign policy — President Trump opposes banning TikTok in the United States at this juncture, and seeks the ability to resolve the issues at hand through political means once he takes office.” The Chinese firm ByteDance had been ordered to divest TikTok or face an outright ban in the US pursuant to a law signed by President Biden earlier this year.SCOTTSDALE, Ariz. — Even when Penn State quarterback Drew Allar gets some praise, it's usually a backhanded compliment. They say he's a good game manager and stays within himself, or that he doesn't try to do too much. They mention he might not be flashy, but he gives the team a chance to win. And here's the thing about Penn State since Allar stepped under center: The Nittany Lions have won games. A lot of them. Sometimes that's hard to remember considering the lukewarm reception he often gets from fans. "I get it — we have a really passionate fan base and they're a huge part of our success," Allar said Sunday at College Football Playoff quarterfinals media day. "For us, we always want to go out there every drive and end with a touchdown, so when we don't do that, there's nobody more frustrated than us." The polarizing Allar is having a solid season by just about any standard, completing more than 68% of his passes for 3,021 yards, 21 touchdowns and seven interceptions while leading the sixth-seeded Nittany Lions to a 12-2 record and a spot in the Fiesta Bowl for Tuesday's game against No. 3 seed Boise State. But in a college football world filled with high-scoring, explosive offenses, Allar's no-frills performances often are the object of ire. The Penn State offense is a run-first bunch, led by the talented combo of Nicholas Singleton and Kaytron Allen. "If we had a nickel for every time there was a Monday morning quarterback saying some BS stuff, we'd all be pretty rich," offensive coordinator Andy Kotelnicki said. "I think part of being a quarterback, especially at Penn State but really anywhere, is how you respond to and manage criticism." The 20-year-old Allar has made strides in that department after a trying 2023 season that finished with a 10-3 record. He says that's largely because once fall camp started back in August, he logged off the social media platform X. Allar said negative online experiences wore on him last year, and his phone number was leaked a few times, which added to the stress. He finally realized that controlling outside narratives was impossible, so the best course of action was to eliminate a needless distraction. "I've been more mentally free, as much as that sounds crazy," Allar said. "I think that's been a huge difference for me this year." The biggest criticism of Allar — and really Penn State as a whole during the 11-year James Franklin era — is that he isn't capable of winning the big games. He's 0-2 against rival Ohio State and threw a late interception against Oregon in the Big Ten title game earlier this month, which sealed the Ducks' 45-37 victory. He wasn't great in the CFP's first round, either, completing just 13 of 22 passes for 127 yards as Penn State muscled past SMU 38-10 on a cold, blustery day to advance to the Fiesta Bowl. But the quarterback is confident a better performance — aided by a game that will be played in comfortable temperatures in a domed stadium — is coming. "For me, I just have to execute those (easy) throws early in the game and get our guys into rhythm," Allar said. "Get them involved early as much as I can and that allows us to stay on the field longer, call more plays and open up our offense more. That will help us a ton, building the momentum throughout the game." Allar might be a favorite punching bag for a section of the Penn State fan base, but that's not the case in his own locker room. Star tight end Tyler Warren praised his quarterback's ability to avoid sacks, saying that the 6-foot-5, 238-pounder brings a toughness that resonates with teammates. "He's a football player," Warren said. "He plays quarterback, but when you watch him play and the energy he brings and the way he runs the ball, he's just a football player and that fires up our offense." Now Allar and Penn State have a chance to silence critics who say that the Nittany Lions don't show up in big games. Not that he's worried about what other people think. "I think it's a skill at the end of the day — blocking out the outside noise," Allar said. "Focusing on you and the process and being honest with yourself, both good and bad." Get local news delivered to your inbox!
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