Score Black Friday-level deals on the TruSkin serums stars loveSmall businesses say cautious shoppers are seeking 'cozy' and 'festive' this holiday season With a late Thanksgiving, the holiday shopping season is five days shorter than last year, and owners of small retail shops say that people have been quick to snap up holiday décor early, along with gifts for others and themselves. Cozy items like sweaters are popular so far. Businesses are also holding special events to get shoppers in the door. But there’s little sense of the freewheeling spending that occurred during the pandemic. Overall, The National Retail Federation predicts retail sales in November and December will rise between 2.5% and 3.5% compared with same period a year ago. Supreme Court will take up a challenge related to California's tough vehicle emissions standards WASHINGTON (AP) — The Supreme Court says it will take up a business-backed appeal that could make it easier to challenge federal regulations, acting in a dispute related to California’s nation-leading standards for vehicle emissions. The justices agreed Friday to hear an appeal filed by fuel producers who object to a waiver granted to California in 2022 by the Environmental Protection Agency during Joe Biden’s presidency. The waiver allows California to set more stringent emissions limits than the national standard. The case won’t be argued until the spring, when the Trump administration is certain to take a more industry-friendly approach to the issue. Musk says US is demanding he pay penalty over disclosures of his Twitter stock purchases DETROIT (AP) — Elon Musk says the Securities and Exchange Commission wants him to pay a penalty or face charges involving what he disclosed — or failed to disclose — about his purchases of Twitter stock before he bought the social media platform in 2022. In a letter, Musk’s lawyer Alex Spiro tells the outgoing SEC chairman, Gary Gensler, that the commission’s demand for a monetary payment is a “misguided scheme” that won’t intimidate Musk. The letter also alleges that the commission reopened an investigation this week into Neuralink, Musk’s computer-to-human brain interface company. The SEC has not released the letter. Nor would it comment on it or confirm whether it has issued such a demand to Musk. Trump hosts Apple CEO at Mar-a-Lago as big tech leaders continue outreach to president-elect WEST PALM BEACH, Fla. (AP) — Donald Trump is hosting Apple CEO Tim Cook for a Friday evening dinner at the president-elect’s Mar-a-Lago resort. That's according to a person familiar with the matter who is not authorized to comment publicly. Trump has said he’s recently spoken with Cook about the company’s long-running tax battles with the European Union. The Republican said in October that he had spoken to Cook weeks after Apple lost its last appeal to avoid paying 13 billion euros ($14.34 billion) in back taxes to Ireland. The Trump transition team and Apple did not respond to a requests for comment about Trump's meeting with Cook. Flight takes kids to visit Santa at North Pole scene in transformed Denver airport hangar DENVER (AP) — More than 100 kids have been treated to an airplane flight and visit to a hangar at Denver International Airport that was transformed into the North Pole. Streamers, paper snowflakes and tufts of cotton resembling feathery snow dotted the plane and seats. The children, including some with serious health issues, were asked before the final approach to draw the shades on their windows. When they opened, the kids were greeted by a waiting Santa and Mrs. Claus and a host of elves. Saturday's event was part of United Airlines’ annual holiday-season “fantasy flights” at airports around the world to bring cheer to children and their families. Senate begins final push to expand Social Security benefits for millions of people WASHINGTON (AP) — The Senate is pushing toward a vote on legislation that would provide full Social Security benefits to millions of people. Senate Majority Leader Chuck Schumer began the process on Thursday for a final vote on the bill, known as the Social Security Fairness Act. It would eliminate policies that currently limit Social Security payouts for roughly 2.8 million people. The legislation has passed the House. The bill would add more strain on the Social Security Trust funds, which are already estimated to be unable to pay out full benefits beginning in 2035. The measure would add an estimated $195 billion to federal deficits over 10 years, according to the Congressional Budget Office. Court denies TikTok's request to halt enforcement of potential US ban until Supreme Court review A federal appeals court has left in place a mid-January deadline in a federal law requiring TikTok to be sold or face a ban in the United States. Judges on the U.S. Court of Appeals for the District of Columbia Circuit rejecting a request made by the company to halt enforcement until the Supreme Court reviews its challenge of the statute. Attorneys for TikTok and its China-based parent company, ByteDance, are expected to appeal to the Supreme Court. It’s unclear if the nation’s highest court will take up the case. But some experts say they expect the justices to weigh in. TikTok is also looking for a potential lifeline from President-elect Donald Trump, who promised to “save” the short-form video platform during the presidential campaign. Saudi Arabia banned film for 35 years. The Red Sea festival is just one sign of the industry's rise JEDDAH, Saudi Arabia (AP) — “My Driver and I” was supposed to be made in 2016, but was scuttled amid Saudi Arabia’s decades-long cinema ban. Eight years later, the landscape for film in the kingdom looks much different. And the star of “My Driver and I” now has an award. Roula Dakheelallah was named the winner of the Chopard Emerging Saudi Talent award at the Red Sea International Film Festival on Thursday. Both the award and the glitzy festival itself are signs of Saudi Arabia’s commitment to shaping a new film industry. The reopening of cinemas in 2018 after 35 years marked a cultural turning point for Saudi Arabia. 'Tis the season for roasting chestnuts. But in the US, native ones are almost gone Right now chestnut enthusiasts are cozying up next to their open fires (or toaster ovens) to roast a holiday snack that has long roots in North America. But the chestnuts they're roasting aren't native, because the American variety has been mostly wiped out by an invasive fungal blight since the 1930s. Researchers are laboring to bring them back, even as they have hit roadblocks and setbacks in attempts to breed or genetically modify a version that can withstand the blight. If and when they succeed, they'll still need to figure out how to plant it and help it thrive in forests that are already under pressure from climate change, globalization and development. Trump offers support for dockworkers union by saying ports shouldn't install more automated systems WASHINGTON (AP) — President-elect Donald Trump is offering his support for the dockworkers union before their contract expires next month at Eastern and Gulf Coast ports. He posted on social media Thursday that he met with union leaders and that any further “automation” of the ports would harm workers. He wrote that the “amount of money saved is nowhere near the distress, hurt, and harm it causes for American Workers.” The International Longshoremen’s Association has until Jan. 15 to negotiate a new contract with the U.S. Maritime Alliance, which represents ports and shipping companies. The Maritime Alliance says the technology will improve worker safety and strengthen our supply chains, among other things.Titans kicker Nick Folk dealing with soreness so Tennessee added insurance
TOKYO , Dec. 15, 2024 /PRNewswire/ -- Representatives from China and Japan shared their insights on promoting artificial intelligence (AI) governance and data sharing at a sub-forum of the 20th Beijing-Tokyo Forum in Tokyo recently. The sub-forum contributed eastern wisdom to AI governance and digital social development, demonstrating the significance of international cooperation for the development of the digital economy, according to Gao Shaolin, advisor at Peking University's Legal Artificial Intelligence Research Center. AI governance framework The participants agreed that the next 10 years will be a critical period for the development of AI. Gao Wen, academician of the Chinese Academy of Engineering (CAE), said since China's State Council issued a guideline on developing AI in 2017, the nation has made significant progress in AI research and development and industrial layout, especially in computing power and 5G network construction. By the end of 2023, China had over half of the world's 1.57 billion 5G users, according to the World Internet Development Report 2024. It ranked second globally in AI and computing power scale, which has laid a solid foundation for the rapid development of AI. Tatsuo Yamazaki , project professor at the International University of Health and Welfare, said it was very meaningful for Japan and China to discuss strengthening AI governance rules. Fumihiko Kamio , research director of the Nomura Research Institute, echoed his view. He emphasized that the core goal of AI technology is to improve productivity and eliminate obstacles to social development, and called on Chinese and Japanese experts to work together to build an AI governance framework to cope with the global challenges. Deepening international cooperation China put forth the Global AI Governance Initiative in October last year. In July, the UN General Assembly adopted a China -sponsored resolution on enhancing international cooperation on AI capacity-building. The participants spoke highly of the Global Cross-Border Data Flow Cooperation Initiative recently proposed by China . They agreed that AI governance requires global collaboration, especially in the formulation of international standards and the construction of ethical frameworks, where China and Japan can play an active role. Ding Wenhua, academician of the CAE, said China and Japan have both similarities and differences in technology development and governance priorities, so deepening cooperation will bring unique value to global AI governance. " China and Japan should deepen AI technology cooperation between enterprises, work together in AI security research, talent exchange, and jointly explore more possibilities for the application of technology," Wang Zhongyuan , president of the Beijing Academy of Artificial Intelligence, said. Balancing development & risks AI governance refers to the guardrails established to ensure AI systems and tools remain safe and ethical and respect human rights. Xu Zhilong , editor-in-chief of Science and Technology Daily, stressed that AI, as a revolutionary technology, has far-reaching impacts on all areas of society and economy. However, its potential risks such as data leakage and the spread of false information should not be ignored. "Technological progress and security ethics should be developed in a balanced way to ensure that AI technology always serves the progress of human civilization," Xu said. AI governance should not only heed the current technological ethics issues, but also prevent possible long-term risks, such as AI going out of human control, according to Toshio Iwamoto , senior corporate advisor of NTT DATA. He said AI R&D and application should abide by the principles of fairness, transparency, safety and availability. Yuan Yue, chairman of Beijing Dataway Horizon, shared his view from the perspective of regulatory models. "Policy choices should be based on the current status and goals of national technological development," Yuan said, adding that China prefers to provide a more friendly development environment for enterprises while ensuring an effective response to risks. SOURCE Science and Technology DailyThousands of UK social media users experiencing ongoing Meta blackout
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Sipavibart is a monoclonal antibody commercialized by , with a leading Phase III program in Coronavirus Disease 2019 (COVID-19). According to Globaldata, it is involved in 6 clinical trials, of which 2 were completed, 3 are ongoing, and 1 is planned. Smarter leaders trust GlobalData The gold standard of business intelligence. The revenue for Sipavibart is expected to reach an annual total of $28 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. Sipavibart Overview AZD-3152 is under development for the treatment of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It acts by targeting spike protein of SARS-CoV-2. The drug candidate is an investigational next-generation long-acting antibody (LAAB) and administered through intravenous and intramuscular routes. AstraZeneca Overview is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The company operates in Europe, the Americas, Asia, Africa and Australasia. is headquartered in Cambridge, Cambridgeshire, the UK. The company reported revenues of (US Dollars) US$45,811 million for the fiscal year ended December 2023 (FY2023), an increase of 3.3% over FY2022. In FY2023, the company’s operating margin was 17.9%, compared to an operating margin of 8.5% in FY2022. In FY2023, the company recorded a net margin of 13%, compared to a net margin of 7.4% in FY2022. The company reported revenues of US$12,938 million for the second quarter ended June 2024, an increase of 2% over the previous quarter. For a complete picture of Sipavibart’s valuation, From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company. The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s .AP Sports SummaryBrief at 5:26 p.m. EST