circus circus reno

circus circus reno

Quarterbacks in spotlight when No. 6 Miami visits Syracuse

Head coach Regis Le Bris praised Sunderland’s “character” to find a late equaliser and draw 1-1 with Bristol City in the Championship. Patrick Roberts struck in the third minute of stoppage-time to cancel out Luke McNally’s second-half strike and maintain the Black Cats’ unbeaten run at the Stadium of Light this season. The late goal came following a frustrating game for the hosts, who retained possession well in the first half, but were unable to trouble the visitors. Asked if the point was deserved , Le Bris said: “I think so because we dominated the game, started well with good tempo. The way we wanted to play with many switches, played into the triangles, created chances. Probably we had a lack of players or bodies in the box to receive the crosses. “I think the first half was positive and the second half was a little bit different because they changed their shape and defended in a different way. “We expected before the game it could be an option for them, but still we struggled a little bit for 15 or 20 minutes. “We were less dominant, they obtained some situations, not very dangerous, but they were close to our box and finally on a set play they found the solution. We had the character to score at the end, the equaliser I think was deserved. “Overall, the game I think we would be frustrated because we were dominant and against this low block we struggled to find the right solution.” Roberts was brought on as a substitute in the 26th minute after Tommy Watson was forced off the pitch with a knock. His goal comes after providing an assist against Stoke at the weekend and the Sunderland boss believes Roberts provides an example for his team-mates. “He made the comeback against Stoke for the victory and today was a late equaliser,” Le Bris added. “It’s a good example of character. If our most experienced player can show that this is the right direction to be ambitious and to achieve our goal in that league, it’s good for the team.” City looked to be sharper after the break and McNally found the breakthrough in the 63rd minute after Sunderland failed to clear their lines. The visitors defended well before Roberts struck and goalkeeper Max O’Leary made a great save to deny Dan Ballard in the final minutes. City’s draw came in the aftermath of a 3-0 defeat to Portsmouth at the weekend and head coach Liam Manning believed his team provided a response, despite the “disappointing” result. “I was looking for a response from the weekend, I was quite honest with everybody, it wasn’t good enough,” he said. “It was hugely disappointing to concede so late, but ultimately, I think the lads gave it absolutely everything which, like I say, I was quite critical of at the weekend. “They left everything out there, the blocks, people putting their bodies on the line, Rob Dickie on his knees heading things clear from the box. “The lads gave absolutely everything. As disappointing as it is, it’s not the worst point.” Did you know that you can get daily SAFC news sent straight to your device as soon as it happens through WhatsApp? It's quick and easy to join. Just click this link and select 'Join Community' to get started. Your informational will be hidden, you'll only ever receive messages from the Chronicle Live sports team, and you can leave any time you like. For more information, click here . You can read our Privacy Notice here.

WARRINGTON, Pa., Nov. 27, 2024 (GLOBE NEWSWIRE) -- Windtree Therapeutics, Inc. (“Windtree” or “the Company”) (NasdaqCM: WINT), a biotechnology company focused on advancing early and late-stage innovative therapies for critical conditions, today reported financial results for the third quarter ended September 30, 2024 and provided key business updates. “The third quarter of 2024 was marked with significant progress. We were very pleased with the SEISMiC B study results in early cardiogenic shock showing significant improvement in many measures of cardiac function and blood pressure along with a favorable safety profile in patients with heart failure and cardiogenic shock. There have been four positive Phase 2 studies with over 300 patients treated with istaroxime resulting in a consistent, unique and attractive drug profile across a wide range of severities,” said Craig Fraser, Chairman and CEO. “With trial execution and active operations comes the need for capital and we successfully completed transactions providing resources for our near-term needs as well as secured an equity line of credit to potentially support future requirements,” Mr. Fraser added. “Looking forward, we plan to accelerate enrollments in the istaroxime SCAI Stage C cardiogenic shock study with a planned interim data read out in early Q2 2025 as well as providing guidance on our strategy and planned activities with our oncology preclinical aPKCi inhibitor assets. Given what we believe to be strong data and market need, the Company is turning attention to business development activities to secure additional licenses and partnerships for our multi-asset cardiovascular platform with the objective to secure non-dilutive capital and partner resources to advance the assets to potential commercialization.” Key Business Updates Announced positive Phase 2b topline clinical results with istaroxime significantly improving cardiac function and blood pressure in heart failure patients with early cardiogenic shock. The study met its primary endpoint in significantly improving systolic blood pressure over six hours (SBP AUC) for the combined Part A and Part B SEISMiC istaroxime group compared to placebo as well as for SEISMiC Part B alone. The improvements in SBP AUC at 24 hours were also significantly increased by istaroxime and the improvements were sustained through 96 hours of measurement. Cardiac output (the amount of blood pumped by the heart over a minute) and filling pressures in the heart significantly improved as did measured kidney function. Heart failure severity as assessed by the NYHA classification decreased significantly up to 72 hours compared to placebo. A favorable safety and tolerability profile, including risk for cardiac arrythmias, was also observed. The clinical study data was presented in a late-breaker session at the Heart Failure Society of America conference and the Company reviewed the clinical results along with the program strategy and plans at a virtual Investor Meeting which has been posted to the Company website. Completed two private placements in July 2024 for aggregate proceeds of approximately $13.9 million, which consisted of approximately $4.4 million of new funding (with $2.3 million of net proceeds) and a $9.5 million payment through the full cancellation and extinguishment of certain holders outstanding senior notes, including secured notes, and shares of the Company’s Series B Convertible Preferred Stock. Entered into a Common Stock Purchase Agreement with an equity line investor, whereby the Company has the right, but not the obligation, to sell such investor, and, subject to limited exceptions, the investor is obligated to purchase for up to $35 million of newly issued shares of the Company’s common stock. Announced initiation of the SEISMiC C study of istaroxime in SCAI Stage C cardiogenic shock to complete Phase 2b and advance the transition to Phase 3. This is a global trial including sites in the U.S., Europe and Latin America. It is a placebo-controlled, double-blinded study with istaroxime being added to current standard of care with inotropes and/or vasopressors. The effect of istaroxime in addition to these therapies will be assessed for 6 hours and based on the patient’s condition, the ability to remove standard of care therapies while on istaroxime will also be assessed. The primary endpoint of the study is assessment of systolic blood pressure (SBP) profile over the first 6 hours of treatment. Expanded patent estate with new patents with istaroxime in cardiogenic shock and acute heart failure. Cardiogenic shock national phase filings were completed for patent applications around the world, including in the United States, Germany, France, Italy, Japan and China. A patent was issued for istaroxime for Japan entitled, “Istaroxime-containing intravenous formulation for the treatment of heart failure and it has been accorded Patent No. 7560134. A patent was issued for istaroxime for Hong Kong, and it is entitled, “Istaroxime-containing intravenous formulation for the treatment of heart failure (AHF).” The claims are directed formulations comprising istaroxime, pharmaceutically acceptable salts thereof, and methods of use, alone, or in combination with other agents useful for the treatment and management of acute heart failure. Select Third Quarter 2024 Financial Results For the third quarter ended September 30, 2024, the Company reported an operating loss of $4.7 million, which was comparable to an operating loss of $4.7 million in the third quarter of 2023. Included in our operating loss for the third quarter of 2024 is $2.2 million related to the change in fair value of our common stock warrant liability and $0.7 million in expenses related to the two private placements completed in July 2024 which were allocated to the warrants issued in those transactions and expensed immediately. Research and development expenses were $2.0 million for the third quarter of 2024, compared to $2.1 million for the third quarter of 2023. Research and development expenses for both periods primarily relate to the SEISMiC Extension trial of istaroxime for the treatment of early cardiogenic shock which completed enrollment during the third quarter of 2024. General and administrative expenses for the third quarter of 2024 were $2.8 million, compared to $2.6 million for the third quarter of 2023. For the third quarter of 2024, general and administrative expenses include $0.7 million in expenses related to the two private placements completed in July 2024 which were allocated to the warrants issued in those transactions and expensed immediately. The Company reported a net loss attributable to common stockholders of $3.8 million ($4.23 per basic share) on 0.9 million weighted-average common shares outstanding for the quarter ended September 30, 2024, compared to a net loss of $4.4 million ($15.47 per basic share) on 0.3 million weighted average common shares outstanding for the comparable period in 2023. As of September 30, 2024, the Company reported cash and cash equivalents of $2.3 million and current liabilities of $14.4 million, which includes an $8.6 million warrant liability. Included in prepaid expenses and other assets as of September 30, 2024 is $0.7 million in receivables related to ELOC Purchase Agreement gross proceeds for sales made during the quarter for which we had not yet received the cash payment. The related net proceeds after the redemption of the Series C Preferred Stock was $0.5 million. In addition, subsequent to September 30, 2024 and through November 22, 2024, we sold an additional 4.3 million shares of Common Stock under the ELOC Purchase Agreement for net proceeds of $2.4 million following mandatory redemption payments on our Series C Preferred Stock. Following these financings, we believe that we have sufficient resources available to fund our business operations through January 2025. Readers are referred to, and encouraged to read in its entirety, the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2024, which was filed with the Securities and Exchange Commission on November 26, 2024, and includes detailed discussions about the Company’s business plans and operations, financial condition, and results of operations. Nasdaq Update On November 21, 2024, the Company received a letter from the Nasdaq Listing Qualifications Staff (“Staff”) of The Nasdaq Stock Market LLC stating that it was not in compliance with Nasdaq Listing Rule 5250(c)(1) as a result of it not having timely filed its Quarterly Report on Form 10-Q (“Form 10-Q”) for the quarter ended September 30, 2024 with the Securities and Exchange Commission. Based on the November 26, 2024 filing of the Company’s Form 10-Q and a subsequent letter received from Nasdaq on November 27, 2024 stating the Staff has determined that the Company complies with Nasdaq Listing Rule 5250(c)(1), this matter is now closed. About Windtree Therapeutics, Inc. Windtree Therapeutics, Inc. is a biotechnology company focused on advancing early and late-stage innovative therapies for critical conditions and diseases. Windtree’s portfolio of product candidates includes istaroxime, a Phase 2 candidate with SERCA2a activating properties for acute heart failure and associated cardiogenic shock, preclinical SERCA2a activators for heart failure and preclinical precision aPKCi inhibitors that are being developed for potential in rare and broad oncology applications. Windtree also has a licensing business model with partnership out-licenses currently in place. Forward Looking Statements This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. The Company may, in some cases, use terms such as "predicts," "believes," "potential," "proposed," "continue," "estimates," "anticipates," "expects," "plans," "intends," "may," "could," "might," "will," "should" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Such statements are based on information available to the Company as of the date of this press release and are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from the Company’s current expectations. Examples of such risks and uncertainties include, among other things: the Company’s ability to secure significant additional capital as and when needed; the Company’s ability to achieve the intended benefits of the aPKCi asset acquisition with Varian Biopharmaceuticals, Inc.; the Company's risks and uncertainties associated with the success and advancement of the clinical development programs for istaroxime and the Company’s other product candidates, including preclinical oncology candidates; the Company’s ability to access the debt or equity markets; the Company’s ability to manage costs and execute on its operational and budget plans; the results, cost and timing of the Company’s clinical development programs, including any delays to such clinical trials relating to enrollment or site initiation; risks related to technology transfers to contract manufacturers and manufacturing development activities; delays encountered by the Company, contract manufacturers or suppliers in manufacturing drug products, drug substances, and other materials on a timely basis and in sufficient amounts; risks relating to rigorous regulatory requirements, including that: (i) the U.S. Food and Drug Administration or other regulatory authorities may not agree with the Company on matters raised during regulatory reviews, may require significant additional activities, or may not accept or may withhold or delay consideration of applications, or may not approve or may limit approval of the Company’s product candidates, and (ii) changes in the national or international political and regulatory environment may make it more difficult to gain regulatory approvals and risks related to the Company’s efforts to maintain and protect the patents and licenses related to its product candidates; risks that the Company may never realize the value of its intangible assets and have to incur future impairment charges; risks related to the size and growth potential of the markets for the Company’s product candidates, and the Company’s ability to service those markets; the Company’s ability to develop sales and marketing capabilities, whether alone or with potential future collaborators; the rate and degree of market acceptance of the Company’s product candidates, if approved; the Company’s ability to maintain compliance with the continued listing requirements of Nasdaq; the economic and social consequences of the COVID-19 pandemic and the impacts of political unrest, including as a result of geopolitical tension, including the conflict between Russia and Ukraine, the People’s Republic of China and the Republic of China (Taiwan), and the evolving events in the Middle East, and any sanctions, export controls or other restrictive actions that may be imposed by the United States and/or other countries which could have an adverse impact on the Company’s operations, including through disruption in supply chain or access to potential international clinical trial sites, and through disruption, instability and volatility in the global markets, which could have an adverse impact on the Company’s ability to access the capital markets. These and other risks are described in the Company’s periodic reports, including its Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K, filed with or furnished to the Securities and Exchange Commission and available at www.sec.gov. Any forward-looking statements that the Company makes in this press release speak only as of the date of this press release. The Company assumes no obligation to update forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release. Contact Information: Eric Curtis ecurtis@windtreetx.comLarson Financial Group LLC lowered its stake in VanEck Junior Gold Miners ETF ( NYSEARCA:GDXJ – Free Report ) by 90.0% during the third quarter, Holdings Channel reports. The institutional investor owned 839 shares of the exchange traded fund’s stock after selling 7,589 shares during the period. Larson Financial Group LLC’s holdings in VanEck Junior Gold Miners ETF were worth $41,000 as of its most recent filing with the SEC. Other large investors have also recently bought and sold shares of the company. Nations Financial Group Inc. IA ADV boosted its holdings in shares of VanEck Junior Gold Miners ETF by 2.6% during the third quarter. Nations Financial Group Inc. IA ADV now owns 15,641 shares of the exchange traded fund’s stock worth $763,000 after acquiring an additional 400 shares during the period. 180 Wealth Advisors LLC boosted its stake in VanEck Junior Gold Miners ETF by 5.5% in the 2nd quarter. 180 Wealth Advisors LLC now owns 7,744 shares of the exchange traded fund’s stock valued at $326,000 after purchasing an additional 405 shares during the period. Ridgewood Investments LLC acquired a new position in VanEck Junior Gold Miners ETF in the 2nd quarter valued at $29,000. Verus Capital Partners LLC increased its position in VanEck Junior Gold Miners ETF by 15.6% during the 3rd quarter. Verus Capital Partners LLC now owns 5,550 shares of the exchange traded fund’s stock worth $271,000 after buying an additional 750 shares during the period. Finally, Arlington Trust Co LLC acquired a new stake in shares of VanEck Junior Gold Miners ETF during the third quarter worth $37,000. VanEck Junior Gold Miners ETF Stock Performance GDXJ stock opened at $47.68 on Friday. VanEck Junior Gold Miners ETF has a 52 week low of $30.89 and a 52 week high of $55.58. The company has a market capitalization of $5.60 billion, a PE ratio of 24.80 and a beta of 1.03. The company’s 50-day simple moving average is $49.66 and its 200 day simple moving average is $46.48. VanEck Junior Gold Miners ETF Company Profile Market Vectors Junior Gold Miners ETF (the Fund) seeks to replicate as closely as possible, before fees and expenses, the price and yield performance of the Market Vectors Junior Gold Miners Index (the Index). The Index provides exposure to a global universe of publicly traded small- and medium-capitalization companies that generate at least 50% of their revenues from gold and/or silver mining, hold real property that has the potential to produce at least 50% of the Company’s revenue from gold or silver mining when developed, or primarily invest in gold or silver. Further Reading Want to see what other hedge funds are holding GDXJ? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for VanEck Junior Gold Miners ETF ( NYSEARCA:GDXJ – Free Report ). Receive News & Ratings for VanEck Junior Gold Miners ETF Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for VanEck Junior Gold Miners ETF and related companies with MarketBeat.com's FREE daily email newsletter .NoneLike many other vital workflows, accounting has evolved with technology over the last several decades. It’s transitioned from manual bookkeeping to rudimentary software to robust desktop applications and finally to cloud-native software as a service. However, while this evolution has naturally made the profession more efficient, some believe that these platforms have started to sacrifice quality in the name of convenience. According to tech entrepreneur and software engineer Gregory Gevorkyan , modern web applications have lost their magic: They’ve become more bloated, slower, and even break if you don’t have an uninterrupted internet connection. Instead of relying on clunky web apps that take several seconds to load, Gevorkyan believes that native desktop apps had it right all along — and with Modernbanc , his next-gen accounting platform, he’s aiming to bring more efficient and user-friendly workflows back into the spotlight. Learn more about how Gevorkyan is balancing emerging technology with common-sense software development. The Challenges of Legacy Accounting Software and an Overreliance on Cloud Computing Accounting as an industry hasn’t exactly kept up with modern technology. Even today, many of the world’s biggest banks still use decades-old systems like FIS, Infosys Finacle, and Temenos T24. While these solutions were cutting-edge tech in their own age, many of them were built 40 years ago and lack support for modern features — not to mention they struggle with complex transactions and increased volumes of data, both of which are all too common in modern business. Meanwhile, technology has propelled the creation of robust accounting software to meet the needs of today’s businesses. Some platforms utilize robotic process automation (RPA) to automate busy work such as invoice and order management, freeing up the precious time of overworked accountants. Other offerings use specialized analytics tools to enhance workflows like auditing, allowing businesses to identify anomalies, trends, and fraud much more efficiently. But today, many of these offerings are only available as cloud software, which Gregory considers a step backward. After all, what’s the point of using cutting-edge technology if it’s reliant on bandwidth and latency? Not only are these connection-reliant web apps limited in performance and accessibility, but their purported convenience often falls flat the instant your internet connection falters. And when finance professionals are spending more money on the cloud than ever before and not seeing significant benefits, something must change. That’s why Gevorkyan believes that building offline-first software is the safer and more performant way to address the challenges of legacy financial systems. Innovating Accounting Software with Modernbanc While contributing to the building of Royal Bank of Scotland’s next-gen online bank , Gregory Gevorkyan became intimately familiar with the weaknesses of legacy banking systems and the shortcomings of cloud-first offerings. These insights are what inspired him to create Modernbanc, an accounting system that is as easy to use as a spreadsheet, allowing users to build reports with live data in seconds. The software offers tools for recording bank balances, making financial reports, and managing assets, compiling them all into an intuitive spreadsheet layout. It also seamlessly integrates with business bank accounts and transactions, with support for over 12,000 financial institutions. This drastically reduces the manual labor accountants are ordinarily faced with, giving them more time to focus on strategic financial planning. Prioritizing an offline-first approach, Modernbanc allows users to build reports regardless of whether they have a connection at the moment (letting them automatically sync when a connection is established), using an app that works seamlessly even without the internet. Rather than depending on clunky web extensions and separate offline spreadsheets, Modernbanc ensures reliable performance regardless of whether the user is connected — marrying the convenience of the cloud with the performance Gevorkyan believes should be the standard for all robust business software. Solving the Efficiency Problem in Accounting As half the industry is relying on outdated software and the other half is counting on unreliable cloud applications, Gevorkyan built Modernbanc with a seamless and streamlined interface in mind, one that is purpose-built for reliability and efficiency. One of the primary ways Modernbanc achieves this is with a simple and straightforward user flow, allowing users to record a payment just by adding a row. Custom reports can be generated in seconds using live data or provided templates, while transactions are automatically categorized and reconciled. Thanks to these simple yet effective features, not only is Modernbanc intuitive to use, but it also avoids the performance bottlenecks that other offerings face when they prioritize flashy features over functionality. And by turning away from the traditional web-app approach of the last 20 years of accounting software, Modernbanc guarantees fast and responsive performance — regardless of connectivity. Building the Future of Accounting Software Accounting software is overdue for a revamp, being one of the few mission-critical applications that haven’t seen much improvement in over 30 years. By offering high performance, a clean UX, responsive offline functionality, and real-time data synchronization, Gregory Gevorkyan is building a new vision for modern accounting with Modernbanc.For more information, check out Modernbanc online .

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Longtime P.E.I. mayor resigns after a contentious vote for pickleball courtsAnyone who watched Naperville North quarterback Jacob Bell’s sensational senior season knew he would be a hot commodity on the recruiting trail. Bell committed to Ball State over the summer, before he threw for 3,075 yards and 38 touchdowns . Even opposing coaches said he could play in a bigger college program. But nothing was certain. “We were hoping that way, but we wouldn’t have been shocked if we didn’t have something come about,” Naperville North coach Sean Drendel said. “With this new recruiting world, nothing is surprising. “When they’re letting 24-, 25-, 26-year-olds still play college football, it becomes really tough for a high school kid. You better be a really good player to be one of those kids that gets a scholarship offer nowadays.” Bell is one of those kids. Three days after taking an official visit to Indiana, Bell committed to the College Football Playoff participant on Tuesday and announced it Wednesday. “It was a relatively unique process for me,” Bell said. “I’ve known Indiana’s staff for a good amount of time, talked to them on and off. “A couple weeks back, they called me up, asked for some of my information, said that an opportunity may be available.” Drendel said that opened up when another quarterback recruit chose to go elsewhere. “They thought they had one of the top five kids in the country, who flipped in December, and then they realized they need to go get a good guy,” Drendel said. “Jacob had visited them before. “When they really started to dig in on Jacob, they really started liking what they saw, and it became apparent in their mind they felt like he was one of the top kids out there, so go get him.” Bell said he liked what he saw during his official visit to Bloomington last weekend. No. 10 Indiana had just lost 27-17 to No. 7 Notre Dame in the first round of the College Football Playoff on Dec. 20. “It was the day after the game against Notre Dame in the college football playoffs, so that was pretty cool to be around that event,” he said. “It was a quick process, but I definitely saw everything I needed to see, met the right people and things like that.” Bell will be joining a program on the rise. Indiana coach Curt Cignetti, who is The Associated Press national coach of the year, led the Hoosiers (11-2) to a school-record number of wins and into the playoffs for the first time. “It’s absolutely awesome,” Bell said. “With how successful that coaching staff is right now and they’re going to be around for a very long time, just signed an extension, it’s just a pretty stable situation in the midst of all the chaos of college football. “It’s definitely something that I’m excited to get into and a program that I’m excited to be a part of.” The chaos in college sports has been caused by the transfer portal and the evolving dynamic of compensation for student-athletes’ name, image and likeness. It has made the recruiting process more difficult for high school players. But Bell, whose older brother Jon is a backup quarterback at South Dakota State, didn’t fret. “Having a brother that’s a college athlete right now, I kind of have a bigger insight into how that stuff works with the portal and some of the demands that schools have,” Bell said. “I didn’t get frustrated with it. I tried to understand it and just be patient with the process, and it ended up paying off.” Indiana has a robust NIL program. Bell said the school’s donors are involved, and he is aware of the opportunities. “Obviously, with the new landscape of college football, it’s a part of it,” he said. “The smart thing to do is always to try to build off of it and build your brand. “That didn’t weigh anything into my commitment. I just knew that they play a brand of football that I like and (offer) a great education, so it was kind of a hard opportunity to pass up.” Bell, who intends to major in business, will do his due diligence to maximize his earning potential. “For sure,” he said. “Once I get into college and get closer to possibly earning a starting spot, that will be definitely be something I put more focus into.” Matt Le Cren is a freelance reporter.

Alabama and Mississippi tumbled out of the top 10 of The Associated Press Top 25 poll Sunday and Miami and SMU moved in following a chaotic weekend in the SEC and across college football in general. Oregon is No. 1 for the sixth straight week and Ohio State, Texas and Penn State held their places behind the Ducks, who are the last unbeaten team. The shuffling begins at No. 5, where Notre Dame returned for the first time since Week 2 after beating Army for its ninth straight win. No. 6 Georgia moved up two spots, No. 7 Tennessee and No. 8 Miami each got a three-rung promotion and No. 9 SMU jumped four places for its first top-10 ranking since 1985. SMU has clinched a spot in the Atlantic Coast Conference title game and would play Miami, if the Hurricanes win at Syracuse this week, or No. 12 Clemson . Indiana dropped from No. 5 to No. 10 following its first loss, a 38-15 defeat at Ohio State. The Buckeyes would play Oregon in the Big Ten championship game if they beat Michigan this Saturday for the first time in four years. The Southeastern Conference's hopes for landing four spots in the College Football Playoff took a hit with two of their teams losing as double-digit favorites. Texas, Georgia and Tennessee are the only SEC teams with fewer than three losses after Alabama lost 24-3 at Oklahoma and Mississippi lost 24-17 at Florida. Alabama and Mississippi each dropped six spots in the AP poll, the Crimson Tide to No. 13 and the Rebels to No. 15. Texas A&M was the third SEC team to lose, 43-41 at Auburn in four overtimes. The Aggies tumbled five places to No. 20 but would play Georgia in the SEC championship game if they knock off Texas this week. Losses by BYU and Colorado created a four-way tie for first in the Big 12. No. 14 Arizona State, picked to finish last in the conference, handed BYU its second straight loss and is the highest-ranked Big 12 team. No. 17 Iowa State earned a five-rung promotion with its win at Utah. BYU is No. 19 and Colorado, which lost to Kansas , is No. 23. If the four teams each finish 7-2 in conference play, it's Iowa State vs. Arizona State in the Big 12 championship game. No. 11 Boise State is first among the four ranked Group of Five teams. The Broncos got a one-spot bump despite struggling to beat a two-win Wyoming team. Tulane is No. 18, UNLV is No. 21 and Army is No. 25. Oregon, which was idle, was the consensus No. 1 team for the fourth straight week. The Ducks will be unbeaten in the regular season for the first time since 2010 if they beat Washington at home Saturday. Boise State's ranking is its highest since it was No. 8 in the final poll of the 2011 season. Arizona State's ranking is its highest since it was No. 12 in the final poll of the 2014 season. Indiana-Ohio State was the final top-five matchup of the regular season. The five were the most in a regular season since 1996. There also were five in 1936 and 1943. No. 24 Missouri, a 39-20 winner at Mississippi State , returned to the Top 25 after a one-week absence. Washington State's four-week run in the rankings ended with its second straight loss, 41-38 loss at Oregon State. SEC — 8 (Nos. 3, 6, 7, 13, 15, 16, 20, 24). Big Ten — 5 (Nos. 1, 2, 4, 10, 22). Big 12 — 4 (Nos. 14, 17, 19, 23). ACC — 3 (Nos. 8, 9, 12). AAC — 2 (Nos. 18, 25). Mountain West — 2 (Nos. 11, 21). Independent — 1 (No. 5). —No. 16 South Carolina at No. 12 Clemson: It's a Top 25 matchup for the first time since 2013. Clemson's 16-7 victory in Columbia last year was the fourth of five straight wins to end the Tigers' season. —No. 3 Texas at No. 20 Texas A&M: Stakes are high for the first meeting of longtime rivals since both were in the Big 12 in 2011. Winner goes to the SEC title game. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballLarson Financial Group LLC Increases Position in CenterPoint Energy, Inc. (NYSE:CNP)

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Israel said Tuesday it had bombed more than 350 military sites in Syria during the previous 48 hours, targeting “most of the strategic weapons stockpiles” in the country. Israeli Prime Minister Benjamin Netanyahu said the wave of airstrikes in neighboring Syria was necessary to keep the weapons from being used against Israel following the Syrian government’s stunning collapse . Israel also acknowledged its troops were pushing into a border buffer zone inside Syria, which was established after the 1973 Mideast war. However, Israel denied its forces were advancing Tuesday toward the Syrian capital of Damascus. Life in the capital was slowly returning to normal after jihadi-led Syrian insurgents ousted President Bashar Assad over the weekend. People celebrated for a third day in a main square, and shops and banks reopened. The United States said Tuesday it would recognize and support a new Syrian government that renounces terrorism, destroys chemical weapons stocks and protects the rights of minorities and women. Syria's nearly 14-year civil war killed nearly half a million people and displaced half of the country’s prewar population of 23 million, becoming a proxy battlefield for regional and international powers. Here's the Latest: BEIRUT — Insurgents who overthrew the Syrian government now say they have wrested control of the eastern city of Deir el-Zour after intense battles with a Kurdish-led, U.S.-backed force. Syria’s rebel military command announced Tuesday evening that they had completely captured the city of Deir el-Zour. A member of the jihadi group Hayat al-Tahrir, which leads the insurgent alliance, said in a recorded video that the group would soon conduct a thorough sweep of the city’s neighborhoods to secure the area, adding that the strategic nearby town of Boukamal has also fallen to opposition forces. “We will advance toward Raqqa and Hasakah and other areas in eastern Syria,” the HTS fighters said. The Kurdish-led Syrian Democratic Forces had only held the city for a few days. The SDF said it deployed to Deir el-Zour and west of the Euphrates River on Friday, replacing Syrian government forces. At the time, the SDF said its fighters were not in control of the Boukamal border crossing with Iraq. Earlier Tuesday, the top U.S. military commander for the Middle East was in eastern Syria for meetings with the SDF. It wasn’t clear if he met with SDF leader Mazloum Abdi. BEIRUT — Syria’s transitional government will made up of members from the rebel-led administration that ruled an insurgent stronghold in the country's northwest, the new prime minister said Tuesday, who called the task “a great challenge.” The caretaker Syrian government, which will oversee the country’s affairs until March, held its first meeting Tuesday since overthrowing former President Bashar Assad. It was attended by the departing Prime Minister Mohammad Ghazi Jalali and other ministers along with new Prime Minister Mohammed al-Bashir. He had led the so-called “salvation government” in areas controlled by rebel groups — led by Hayat Tahrir al-Sham, or HTS — that have taken control of much of the country. “We were tasked by the general command with managing the affairs of the Syrian government during a transitional period,” Bashir said in a statement following the meeting in Damascus. He added that he hopes ministers in the former Syrian government will assist the new government during this transitional period. “The caretaker government was formed from a number of ministers of the revolutionary government, which is the Syrian Salvation Government, and this government is a temporary caretaker government that will last until March 2025, until the constitutional issues are resolved,” Bashir said. The insurgent alliance is led by a former senior al-Qaida militant , Abu Mohammed al-Golani, who cut ties with the extremist group years ago and has promised representative government and religious tolerance. SAYDNAYA, Syria — Tens of thousands came to Saydnaya Prison from all over Syria after the fall of former President Bashar Assad to search for their loved ones. The place so notorious for its horrors was long known as “the slaughterhouse.” For the past two days, all have been looking for signs of loved ones who disappeared years or even decades ago into the secretive, sprawling prison just outside Damascus. But hope gave way to despair Monday. People opened the heavy iron doors lining the hallways to find cells inside empty. With sledgehammers, shovels and drills, men pounded holes in floors and walls, looking for what they believed were secret dungeons, or chasing sounds they thought they heard from underground. They found nothing. Insurgents freed dozens of people from the Saydnaya military prison on Sunday when Damascus fell. Since then, almost no one has been found. “Where is everyone? Where are everyone’s children? Where are they?” said Ghada Assad, breaking down in tears. An estimated 150,000 people were detained or went missing in Syria since 2011 — and tens of thousands of them are believed to have gone through Saydnaya. WASHINGTON — The top U.S. military commander for the Middle East was on the ground in Syria on Tuesday, meeting with a Kurish-led, U.S.-allied force at several bases in the country's east, U.S. Central Command said. Army Gen. Erik Kurilla visited with U.S. military commanders and troops as well as the Kurdish-led Syrian Democratic Forces. It wasn’t clear if he met with SDF leader Mazloum Abdi, and U.S. Central Command did not respond to a request for details about his visit or with whom he met. U.S. officials said they did not know what his message to the SDF was. The U.S has about 900 troops in Syria, including forces working with Kurdish allies in the northeast to prevent any resurgence of the Islamic State group. In a press release, Central Command said Kurilla received an “assessment of force protection measures, the rapidly evolving situation, and ongoing efforts to prevent ISIS from exploiting the current situation.” Kurilla then went on to Iraq where he met with leaders in Baghdad. UNITED NATIONS – The United Nations says it still getting reports about the looting of warehouses with humanitarian aid in a number of areas in Syria, including around the capital Damascus. U.N. spokesman Stephane Dujarric told reporters Tuesday that U.N. agencies and their partners are working to identify the extent of looting at the warehouses, including those of U.N. agencies and the Syrian Arab Red Crescent. Dujarric said U.N. aid officials report that “the humanitarian situation remains volatile across Syria, with reports of people continuing to be displaced.” Humanitarian officials reported that 25 trucks carrying U.N. aid crossed from Turkey to northwest Syria, which the situation is now relatively calm, the U.N. spokesman said. All 11 receptions opened in Idlib in the northwest to host newly displaced families were empty as of Monday, Dujarric said. In the northeast, he said, authorities report that as of Tuesday 100,000 people have been displaced due to fighting in Tal Rifaat and other parts of Aleppo governorate. Dujarric said the U.N.’s partners report that “reception centers in Tabqa and Raqqa have reached full capacity, and more than 200 sites – including municipal buildings, schools, mosques, and stadiums – are being used to accommodate newly displaced people.” BEIRUT — The Lebanese army said Tuesday that “unidentified gunmen” crossed the border from Syria into eastern Lebanon's Bekaa province and approached a Lebanese border post. In a statement, the army said the gunmen fired into the air and seized equipment from an evacuated Syrian army post in the outskirts of Kfar Fouq, near Rashaya al-Wadi, in the western part of Bekaa province. Lebanese army personnel responded with warning shots, forcing the group to retreat back into Syrian territory. The Lebanese army did not report any injuries or provide further details about the identity of the gunmen. WASHINGTON — Yemen’s Houthi rebels launched multiple drones and a missile at three commercial ships being escorted in the Gulf of Aden by U.S. Navy ships, a U.S. official said Tuesday. There was no damage and no injuries. The official, who spoke on condition of anonymity to discuss military operations, said U.S. Navy destroyers, and Navy helicopter and a French Air Force aircraft shot down four of the drones and the missile. The three U.S. affiliated flagged ships were sailing east toward Djibouti. The Iran-backed Houthis have targeted shipping through the key waterway for more than a year, attacks they say are meant to force an end to Israel’s war against Hamas in Gaza. JERUSALEM — Israel’s military said it bombed more than 350 sites in Syria during the previous 48 hours, targeting “most of the strategic weapons stockpiles” in the country. There is concern that, with the sudden collapse of the Syrian government, weapons stockpiles could be seized by jihadi militants. Warplanes hit what Israel said were Syrian air defense systems, military airfields, missile depots, and dozens of weapons production sites in the cities of Damascus, Homs, Tartus, Latakia, and Palmyra, the Israeli army statement said. In naval operations overnight Monday, Israeli missile ships struck two Syrian navy facilities simultaneously — Al-Bayda port and Latakia port — where the army said 15 Syrian naval vessels were docked. Israeli did not specify how many Syrian naval vessels were hit. The private security firm Ambrey said it had seen evidence that at least six Soviet-era Syrian navy missile ships were hit. Israeli officials said earlier that Israel also targeted alleged chemical weapons sites. JERUSALEM — Israeli Prime Minister Benjamin Netanyahu confirmed Tuesday that his country’s military launched a wave of airstrikes across Syria to destroy the toppled government’s leftover “military capabilities,” and said Israel wants relations with the new government emerging Syria. Hours after Israeli warplanes pounded Syria, Netanyahu said Israeli doesn’t want to meddle in Syria’s internal affairs, but would take necessary steps to protect Israel's security and prevent jihadi militants from seizing the Syrian army assets. He warned that if the new Syrian government “allows Iran to re-establish itself in Syria or allows the transfer of Iranian weapons or any other weapons to Hezbollah, or attacks us -- we will respond forcefully and we will exact a heavy price from it.” He spoke in a video statement recorded at the Kirya military headquarters in Tel Aviv, after his first day of testimony in his corruption trial. DAMASCUS, Syria — In Umayyad Square in Damascus, Syrians celebrated the fall of President Bashar Assad for the third day on Tuesday despite Israeli airstrikes across the country. Insurgents who recently took control of the capital city tried to impose a new rule banning the celebratory gunfire. There were a few violators, and much less deafening gunfire. Protesters climbed the square's central monument to wave the Syrian revolutionary flag. On the ground, crowds chanted: “Out with Bashar! Out with Bashar!” Assad fled to Russia over the weekend after a lightning rebel offensive toppled his brutal police state. Demonstrators from different provinces marched in the square in groups, celebrating Assad's fall. Men on motorcycles and horses paraded into the square. One woman from Idlib province shouted that the Israeli strikes ruined the joy of ousting Assad. “Why are you striking us? We just deposed a tyrant,” she said. “Give us peace. Leave us alone,” said Ahmed Jreida, 22, a dentist student, when asked about the Israeli airstrikes. Hamzeh Hamada, 22, said this was the first time he had gone out to a demonstration. “We want the country to get better, to live in dignity and be like other countries that respect citizens’ rights and where there are no bribes,” he said. “We have suffered a lot from bribes. ... We had to bribe people for very minor things; things that should be our right.” Abdul-Jalil Diab was taking a stroll with his brothers in another square in western Damascus. He said he came back from Jordan the day Damascus fell. He was there studying German to prepare to move to Germany and said he is now reconsidering his plans. He was ecstatic, saying words can’t describe how he feels. “We are happy to get rid of the corrupt regime that was based on bribes. The whole country feels better. Everyone is happy and celebrating,” Abdul-Jalil Diab said. QAMISHLI, Syria — Residents of northeast Syria in the area around Qamishli airport said Tuesday they heard explosions overnight after an airstrike hit trucks loaded with rockets and ammunition that were heading to a military base in Tartab. “We don’t know the story. It was only in the morning when we realized they are trucks loaded with ammunition, leftovers of the former army, the regime,” said Ibrahim al-Thalaj, who lives near the base. He said residents assumed that the strikes were Israeli. Israel has carried out a heavy wave of airstrikes across Syria targeting military infrastructure after Syrian insurgents toppled the government of Bashar Assad. However, Turkish security officials said Tuesday that the strike in Qamishli was carried out by Turkey, targeting weapons and ammunition that were abandoned by the Syrian army and seized by Syrian Kurdish militants. The explosions lasted for over 20 minutes after the strike, and many houses in the surrounding area were damaged as a result, residents of the area said. “We just felt a strike hitting. It hit the first one (truck) and we saw the other trucks retreating back, and from there rockets and shells started flying over,” said Hamid al-Asaad, an eyewitness from Qub al-Zeki village in Qamishli. “We were sitting when these explosions started to hit the house,” said Mahmoud Hamza of Tartab. “It was hitting randomly and we didn’t know where it was coming from. ... Once we got out of our house, a rocket hit the house.” There were no details released by the local Kurdish administration regarding the explosions, but members of the Kurdish-led Syrian Democratic Forces blocked the road to the base. BRUSSELS — The European Union’s top diplomat is concerned that Syria might violently fall apart like neighboring Iraq, or Libya and Afghanistan if its territorial integrity and the rights of minorities are not protected. “The transition will present huge challenges in Syria and in the region,” EU foreign policy chief Kaja Kallas told European lawmakers on Tuesday during a special hearing. “There are legitimate concerns about the risks of sectarian violence, extremist resurgence and the governance vacuum, all of which must be averted. We must avoid a repeat of the horrific scenarios of Iraq, Libya and Afghanistan,” she said. “The rights of all Syrians, including those of many minority groups, must be protected,” she said. “It is crucial to preserve the territorial integrity of Syria, and to respect its independence, its sovereignty, as well as the state institutions.” Kallas also said the collapse of the government has shown that Assad’s backers in Russia and Iran “could neither afford to do it any longer, nor had any interest of being present in the aftermath.” “They are weakened, distracted and overstretched in other theaters in the broader Middle East, but also in Ukraine,” she said. ANKARA, Turkey — Turkey’s intelligence agency, MIT, has attacked a convoy of trucks that was allegedly carrying missiles, heavy weapons and ammunition that were abandoned by the Syrian government and reportedly seized by Syrian Kurdish militias, Turkish security officials said Tuesday. The officials said 12 trucks, two tanks and two ammunition depots were “destroyed” in aerial strikes in the city of Qamishli, near the border with Turkey in northeast Syria. The officials provided the information on condition of anonymity in line with Turkish regulations. They did not say when the attack occurred. The officials said the intelligence agency detected that weapons left by the Syrian government forces were being moved to warehouses belonging to the Syrian Kurdish People’s Defense Units, or YPG. Turkey views the group as a terrorist organization because of its links to the banned Kurdish militants that have led a decadeslong insurgency in Turkey. According to the officials, he group was allegedly planning to use the equipment and supplies against Turkish security forces. By Suzan Fraser WASHINGTON — The White House is signaling its approval of Israel’s strikes against Syrian military and alleged chemical weapons targets and the seizure of a buffer zone in the Syrian Golan Heights after the fall of the Assad government. “These are exigent operations to eliminate what they believe are imminent threats to their national security,” White House national security spokesman John Kirby said Tuesday, saying the U.S. would leave it up to the Israelis to discuss details of their operations. “They have as always the right to defend themselves,” Kirby said. He declined to detail and U.S. intelligence cooperation with the Israelis that went into the strikes. Kirby said the White House was reasserting its support of the 1974 Golan Heights disengagement agreement, but didn’t criticize the Israeli seizure of the demilitarized zone. Israel has a long history of seizing territory during wars with its neighbors and occupying it indefinitely , citing security concerns. Israel captured the Golan Heights from Syria in the 1967 Mideast war and annexed it in a move not recognized internationally, except by the United States. WASHINGTON — The Biden administration says it will recognize and support a new Syrian government that renounces terrorism, destroys chemical weapons stocks and protects the rights of minorities and women. Secretary of State Antony Blinken said in a statement Tuesday that the U.S. would work with groups in Syria and regional partners to ensure that the transition from President Bashar Assad’s deposed government runs smoothly. He was not specific about which groups the U.S. would work with. Blinken says Syrians should decide their future and that other countries should “support an inclusive and transparent process” and not interfere. “The United States will recognize and fully support a future Syria government that results from this process,” he said. “We stand prepared to lend all appropriate support to all of Syria’s diverse communities and constituencies.” DAMASCUS, Syria — Jihad Mustafa Shibani was taking his new motorcycle for a spin with a friend around the house of the deposed Syrian president in western Damascus on Tuesday. Shibani was released from prison a week before the capital Damascus fell, after he served two years on charges of buying his motorcycle using foreign currency on accusations he was dealing in dollars. He was tortured for 15 days and and given a quick trial where he was sentenced for two years, he said. He was released the day Aleppo fell to the insurgents. “Everything was banned in Syria. The (Assad loyalists) only could use it,” Shibani said. He said he has never been to this neighborhood, because it was taken over by Assad, his family and supporters. “For 50 years, my family’s house is near here, and we don’t know anything about it. ... The Syrian people had been oppressed, you can’t imagine.” Shibani said he has no fear of the rebel newcomers who have taken control of the country. “We are not afraid. There can be no one more unjust than Bashar. Impossible.” BEIRUT — Lebanon’s prime minister is in contact with security and judicial officials to follow up on reports that senior members of President Bashar Assad’s government have fled to Lebanon. Najib Mikati’s office quoted him as saying that Lebanon abides by international laws regarding people who cross its borders. Rami Abdurrahman of the Britain-based Syrian Observatory for Human Rights, an opposition war monitor, said that several top security officials have entered Lebanon over the past two days. Abdurrahman added that Syria’s former intelligence chief Ali Mamlouk, who is wanted in Lebanon over two bombings in 2012 in the northern city of Tripoli that killed dozens, was allegedly brought to Lebanon by the Hezbollah militant group and was staying in a southern suburb of Beirut where the group has deep support. Lebanon’s Interior Minister Bassam Mawlawi, whose ministry is in charge of border crossings, told reporters Tuesday that no person who is wanted in Lebanon entered the country through legal border crossings. There are dozens of illegal border crossings between Lebanon and Syria where people are usually smuggled in and out of Lebanon, but it was not possible to independently confirm whether Mamlouk had entered Lebanon. GENEVA — The United Nations says humanitarian operations in two major areas in northwestern Syria have resumed, deploying food, medical supplies, fuel and other needed services and supplies. Spokesman Jens Laerke of the U.N. Office for the Coordination of Humanitarian Affairs reported that some health facilities were “overwhelmed” – in part due to staff shortages – and many border crossings have been closed, disrupting supply chains. OCHA said humanitarian operations in some parts of northwestern Syria were put on hold in the early days of the recent escalation, and resumed on Monday. “As of yesterday, all humanitarian organizations in Idlib and northern Aleppo have resumed operations,” Laerke told reporters at a U.N. briefing in Geneva. He said the three border crossings from Turkey used by the U.N. to deliver assistance into Syria remain open and “we are providing assistance in the northwest, including to those who have been newly displaced.” Even before the latest escalation, which led President Bashar Assad to flee the country, nearly 17 million people in Syria needed humanitarian assistance. More than 1 million have been displaced across Idlib, Aleppo, Hama and Homs since the escalation. JERUSALEM — Israel's Defense Minister Israel Katz said Tuesday that Israel's military destroyed Syria’s fleet overnight and intends to establish a demilitarized zone “in southern Syria” to prevent attacks on Israel. He also issued a warning to Syria’s rebels, saying that “whoever follows Assad’s path will end up like Assad — we will not allow an extremist Islamic terrorist entity to act against Israel across its border while putting its citizens at risk.” Speaking at a naval base in Haifa, Katz said the Israeli navy “operated last night to destroy the Syrian fleet and with great success.” Video showing the smoking wreckage of what appeared to be small Syrian naval ships in the port at Latakia was broadcast by Saudi-owned television station Al-Hadath on Tuesday. The Britain-based Syrian Observatory for Human Rights, which has closely tracked the conflict since the civil war erupted in 2011, said Israel targeted Syrian warships, military warehouses and an air-defense facility on the coast. Katz added that he had instructed the army to establish a “defense zone free of weapons and terrorist threats in southern Syria, without a permanent Israeli presence, in order to prevent terrorism in Syria from taking root and organizing.” It was unclear if the demilitarized zone would reach beyond the buffer zone that Israel has taken over in the border area. Israel has a long history of seizing territory during wars with its neighbors and occupying it indefinitely , citing security concerns. Israel captured the Golan Heights from Syria in the 1967 Mideast war and annexed it in a move not recognized internationally, except by the United States. DAMASCUS, Syria — Members of the Syrian government under ousted President Bashar Assad will gradually transfer power to a new transitional cabinet headed by Mohammed al-Bashir. The departing government met with al-Bashir for the first time since Assad fled Damascus over the weekend. Al-Bashir had previously led the “salvation government” running the rebel stronghold in northwest Syria. Al-Bashir told reporters after the meeting that the ministers discussed transferring the portfolios to the interim government during the transitional period until the beginning of March. He said that in the coming days the new government will decide on each ministry. DAMASCUS, Syria — Banks and shops are reopening in Damascus after the chaos and confusion of the first two days following the ouster of President Bashar Assad. Sadi Ahmad, manager of Syria Gulf Bank, said life is returning to normal. A customer who came to withdraw money from an ATM was surprised to see it functioning. At the historic Hamadiyeh market, fighters who seized power were still standing guard but shops had reopened — even an ice cream stand. Resident Maysoun Al-Qurabi said she was initially “against what happened,” referring to the insurgency, but changed her mind after seeing footage of rebels releasing inmates from the notorious Saydnaya prison. “People are at ease and secure now,” she said. “Before, people were hungry and scared.” DAMASCUS, Syria — Minority Christians in Syria have been living in a state of uneasy anticipation since insurgents headed by the Islamic militant group Hayat Tahrir Al-Sham took control after ousting President Bashar Assad. Mazen Kalash, a resident of Bab Touma, a Christian neighborhood in Damascus, said he wants to know the plans of the new government that will be formed by the rebels. “The important thing is to feel safe, bring order, law and respect to the citizens,” he said. “We need to be able to work whatever we want and do whatever we want without any interference from anyone.” The insurgents have so far attempted to reassure minorities that they will be protected. Large numbers of Syrian Christians, who made up 10% of the population, fled after the civil war erupted in 2011. Many of those who stayed supported Assad out of fear they might be targeted by Islamist insurgents. TEL AVIV, Israel — Israeli Prime Minister Benjamin Netanyahu lashed out at media during testimony at his corruption trial, which involves media moguls. “There has never been such a biased media in any democracy ... as there is in Israel,” Netanyahu told the court, describing his testy relationship with the press. He is accused of exchanging regulatory favors with media bosses for more positive coverage of himself and his family. He has denied wrongdoing. GENEVA — The U.N. envoy for Syria says armed groups that drove out President Bashar Assad have “been sending good messages” about national unity and inclusiveness but acknowledges that a Security Council resolution still counts the leading one as a terrorist group. With Syria’s future and stability still very much in flux since Assad’s departure over the weekend, Geir Pedersen suggested that the international community needs to help the country get through this turbulent moment. “We are still in what I would call a very fluid period. Things are not settled,” Pedersen told reporters at U.N. offices in Geneva on Tuesday. “There is a real opportunity for change, but this opportunity needs to be grasped by the Syrians themselves and supported by the U.N. and the international community.” Referring to Israeli military strikes in Syria, Pedersen said it was “extremely important that we now don’t see any action from any international country that destroys the possibility for this transformation in Syria to take place.” The insurgents are led by Hayat Tahrir al-Sham, or HTS, which grew out of an al-Qaida-affiliate called the Nusra Front that the Security Council listed as a terror group in a 2015 resolution. “This is obviously a complicating factor for all of us,” Pedersen said. “But we also have to be honest, we have to look at the facts and to see what has happened during the last nine years.” “The reality so far is that the HTS and also the other armed groups have been sending good messages to the Syrian people,” he said. “They have been sending messages of unity, of inclusiveness, and frankly speaking, also, we have seen in (the captured cities of) Aleppo and in Hama ... reassuring things on the ground." Ahmad al-Sharaa, previously known by his nom de guerre Abu Mohammed al-Golani, the leader of the insurgency and the founder of both groups Nusra and HTS, cut ties with al-Qaida in 2016 and says he is committed to pluralism and religious tolerance. ANKARA, Turkey — Turkey has “strongly” condemned Israel’s advance into Syrian territory, saying it was in violation of a 1974 agreement on a buffer zone inside Syria. “We strongly condemn Israel’s violation of the 1974 Separation of Forces Agreement, its entry into the separation zone between Israel and Syria, and its advance into Syrian territory,” Turkey’s Foreign Ministry said in a statement. The ministry accused Israel of “displaying a mentality of an occupier” at a time when the possibility of peace and stability had emerged in Syria. The statement also reiterated Turkey’s support to Syria’s “sovereignty, political unity, and territorial integrity.” Israeli troops on Sunday entered the buffer zone that had been established after the 1973 Mideast war and the military said it would deploy in “several other places necessary for (Israel’s’) defense.” TEL AVIV, Israel — Prime Minister Benjamin Netanyahu says he works 17 to 18 hours a day and that he is engulfed in meetings, especially during the past year that Israel has been fighting wars. Netanyahu was testifying in his long-running corruption trial. He has denied charges of fraud, breach of trust and accepting bribes in three separate cases. “If only I could steal away five minutes to enjoy some time with my wife,” he told the court Tuesday. TEL AVIV, Israel — An Israeli military official says troops plan to seize a buffer zone inside Syria as well as “a few more points that have strategic meaning.” The official spoke Tuesday on condition of anonymity in line with regulations. The official dismissed reports of a larger Israeli invasion as “rumors.” Prime Minister Benjamin Netanyahu said Sunday that Israeli forces were moving to control a roughly 400-square-kilometer (155-square-mile) demilitarized buffer zone in Syrian territory. The buffer zone between Syria and the Israeli-controlled Golan Heights was created by the U.N. after the 1973 Mideast war. Following the overthrow of President Bashar Assad, Israel sent troops into the buffer zone. It said the move was temporary and was aimed at preventing attacks. It said the 1974 agreement establishing the zone had collapsed and that Syrian troops had withdrawn from their positions. Israel has also carried out airstrikes across Syria in recent days targeting what it says are suspected chemical weapons and long-range rockets. Egypt and Saudi Arabia have condemned Israel’s incursion, accusing it of exploiting the disarray in Syria and violating international law. Israel captured the Golan Heights from Syria in the 1967 Mideast war and annexed it in a move not recognized by the international community, except for the United States. The rest of the world views the strategic plateau as occupied Syrian territory. — By Joseph Krauss DAMASCUS, Syria — Israel’s air force has carried out hundreds of airstrikes in different parts of Syria as its ground forces move north of the Golan Heights along the border with Lebanon, according to an opposition war monitor. The Britain-based Syrian Observatory for Human Rights said Tuesday that since the fall of President Bashar Assad’s government, Israel’s air force has carried out more than 300 airstrikes against research centers, arms depots and military infrastructure across Syria, as well as a naval base along the Mediterranean coast. Associated Press journalists in Damascus witnessed intense airstrikes on the city and its suburbs overnight into Tuesday morning. Photographs posted online by activists showed destroyed missile launchers, helicopters and warplanes. Meanwhile, Israeli troops marched along the border with Lebanon and now control a long stretch on the Syrian side facing Lebanon’s Rashaya region, according to the war monitor's head, Rami Abdurrahman, and the Beirut-based Al-Mayadeen TV, which has reporters in Syria. Israeli troops are now about 25 kilometers (15 miles) southwest of Damascus, according to the monitor. DUBAI, United Arab Emirates — Saudi Arabia has condemned Israel’s incursion into a buffer zone in Syria and a wave of Israeli airstrikes launched after the overthrow of President Bashar Assad. The Saudi Foreign Ministry said in a statement Tuesday that “the assaults carried out by the Israeli occupation government, including the seizure of the buffer zone in the Golan Heights, and the targeting of Syrian territory confirm Israel’s continued violation of the principles of international law and its determination to sabotage Syria’s chances of restoring its security, stability and territorial integrity.” Israel sent troops into a buffer zone inside Syria that had been established after the 1973 Mideast war. It said the move was temporary and was taken to prevent any cross-border attacks after Syrian troops withdrew. Israel has also carried out heavy airstrikes that it says are aimed at preventing suspected chemical weapons and long-range rockets from falling into the hands of extremists. Saudi Arabia has been in talks with the United States in recent years over normalizing relations with Israel in exchange for a U.S. defense pact, American assistance in establishing a civilian nuclear program and a pathway to the establishment of a Palestinian state. But the kingdom has also repeatedly condemned Israel’s actions in the Gaza Strip, where it is at war with the Hamas militant group. Last month, Saudi Arabia’s crown prince and day-to-day ruler Mohammed bin Salman accused Israel of committing genocide in Gaza , allegations Israel adamantly rejects.Alabama and Mississippi tumbled out of the top 10 of The Associated Press Top 25 poll Sunday and Miami and SMU moved in following a chaotic weekend in the SEC and across college football in general. Oregon is No. 1 for the sixth straight week and Ohio State, Texas and Penn State held their places behind the Ducks, who are the last unbeaten team. The shuffling begins at No. 5, where Notre Dame returned for the first time since Week 2 after beating Army for its ninth straight win. No. 6 Georgia moved up two spots, No. 7 Tennessee and No. 8 Miami each got a three-rung promotion and No. 9 SMU jumped four places for its first top-10 ranking since 1985. SMU has clinched a spot in the Atlantic Coast Conference title game and would play Miami, if the Hurricanes win at Syracuse this week, or No. 12 Clemson . Indiana dropped from No. 5 to No. 10 following its first loss, a 38-15 defeat at Ohio State. The Buckeyes would play Oregon in the Big Ten championship game if they beat Michigan this Saturday for the first time in four years. The Southeastern Conference's hopes for landing four spots in the College Football Playoff took a hit with two of their teams losing as double-digit favorites. Texas, Georgia and Tennessee are the only SEC teams with fewer than three losses after Alabama lost 24-3 at Oklahoma and Mississippi lost 24-17 at Florida. Alabama and Mississippi each dropped six spots in the AP poll, the Crimson Tide to No. 13 and the Rebels to No. 15. Texas A&M was the third SEC team to lose, 43-41 at Auburn in four overtimes. The Aggies tumbled five places to No. 20 but would play Georgia in the SEC championship game if they knock off Texas this week. Losses by BYU and Colorado created a four-way tie for first in the Big 12. No. 14 Arizona State, picked to finish last in the conference, handed BYU its second straight loss and is the highest-ranked Big 12 team. No. 17 Iowa State earned a five-rung promotion with its win at Utah. BYU is No. 19 and Colorado, which lost to Kansas , is No. 23. If the four teams each finish 7-2 in conference play, it's Iowa State vs. Arizona State in the Big 12 championship game. No. 11 Boise State is first among the four ranked Group of Five teams. The Broncos got a one-spot bump despite struggling to beat a two-win Wyoming team. Tulane is No. 18, UNLV is No. 21 and Army is No. 25. Oregon, which was idle, was the consensus No. 1 team for the fourth straight week. The Ducks will be unbeaten in the regular season for the first time since 2010 if they beat Washington at home Saturday. Boise State's ranking is its highest since it was No. 8 in the final poll of the 2011 season. Arizona State's ranking is its highest since it was No. 12 in the final poll of the 2014 season. Indiana-Ohio State was the final top-five matchup of the regular season. The five were the most in a regular season since 1996. There also were five in 1936 and 1943. No. 24 Missouri, a 39-20 winner at Mississippi State , returned to the Top 25 after a one-week absence. Washington State's four-week run in the rankings ended with its second straight loss, 41-38 loss at Oregon State. SEC — 8 (Nos. 3, 6, 7, 13, 15, 16, 20, 24). Big Ten — 5 (Nos. 1, 2, 4, 10, 22). Big 12 — 4 (Nos. 14, 17, 19, 23). ACC — 3 (Nos. 8, 9, 12). AAC — 2 (Nos. 18, 25). Mountain West — 2 (Nos. 11, 21). Independent — 1 (No. 5). —No. 16 South Carolina at No. 12 Clemson: It's a Top 25 matchup for the first time since 2013. Clemson's 16-7 victory in Columbia last year was the fourth of five straight wins to end the Tigers' season. —No. 3 Texas at No. 20 Texas A&M: Stakes are high for the first meeting of longtime rivals since both were in the Big 12 in 2011. Winner goes to the SEC title game. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballSalamanca punches ticket to state title game