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Kansas City (14-1) at Pittsburgh (10-5) Wednesday, 1 p.m., EST, Netflix. BetMGM NFL Odds: Chiefs by 2 1/2. Against the spread: Chiefs 7-8; Steelers 10-5 Series record: Steelers lead 25-14. Last meeting: Chiefs beat Steelers 42-21 in the first round of the playoffs on Jan. 16, 2022, in Kansas City. Last week: Chiefs beat Texans 27-19; Steelers lost to Ravens 34-17 Chiefs offense: overall (13), rush (15), pass (12), scoring (11). Chiefs defense: overall (3), rush (3), pass (17), scoring (3). Steelers offense: overall (19), rush (11), pass (25), scoring (12). Steelers defense: overall (11), rush (8), pass (20), scoring (7). Turnover differential: Chiefs plus-4; Steelers plus-16. Chiefs player to watch WR Marquise Brown, who hurt his shoulder on the first play of the preseason and landed on injured reserve, made an impressive regular-season debut against Houston last week. “Hollywood” caught five passes for 45 yards, including an early 13-yarder that converted a fourth down and led to an eventual touchdown. But perhaps most importantly, Brown's mere presence kept Houston from double-teaming Xavier Worthy, DeAndre Hopkins and Travis Kelce all afternoon. Steelers player to watch LB T.J. Watt. The perennial All-Pro is dealing with an ankle injury and had a quiet game in the loss to Baltimore, finishing with just four tackles and didn’t have a single hit against Ravens QB Lamar Jackson. Pittsburgh's best chance at pulling the upset relies heavily on disrupting Kansas City QB Patrick Mahomes at every turn. To do it, Watt will need to do some Watt-like things. The 30-year-old leads the NFL in forced fumbles for a defense that thrives on takeaways. Key matchup Steelers RBs Jaylen Warren and Najee Harris against the Chiefs rush defense, which is ranked third in the NFL and allowing just 91.4 yards per game. The Chiefs held the Texans' Joe Mixon to just 57 yards rushing last week, the latest in a season-long trend of shutting down top running backs. The Browns' Nick Chubb had 41 yards the previous week, and the Ravens' Derrick Henry, the Falcons' Bijan Robinson and the Saints' Alvin Kamara are among those who have similarly struggled against Kansas City. Key injuries Chiefs: LT D.J. Humphries (hamstring) and CB Chamarri Conner (concussion) are likely to miss a second straight game. DT Chris Jones (calf) and RT Jawaan Taylor (knee) are iffy after getting hurt against Houston. Steelers: WR George Pickens (hamstring) should return after missing the past three games. S DeShon Elliott (hamstring) and DT Larry Ogunjobi (groin) may also be back after sitting the past two weeks. Starting CB Joey Porter Jr. (knee) and backup wide receiver/special teams ace Ben Skowronek (hip) are out. Series notes The Steelers have dominated the series, leading 23-14, but the Chiefs have won the past three games. That includes a 42-21 rout in their most recent matchup in the wild-card round of the playoffs on Jan. 16, 2022 — the last game played by Pittsburgh quarterback Ben Roethlisberger. Prior to the Chiefs' three-game win streak, the Steelers had won three in a row, including an 18-16 victory in the divisional round on Jan. 15, 2017, that they won despite not scoring a touchdown. Stats and stuff Kansas City can clinch the No. 1 seed and first-round playoff bye with a win over the Steelers, or if the Bills lose or tie when they play the Jets on Sunday. ... Pittsburgh has dropped two straight, but can still earn its first AFC North title since 2020 by winning its last two games. ... The Chiefs can set a franchise record for regular-season wins with their 15th by beating Pittsburgh or Denver in their regular-season finale, breaking a tie with the 2020 and ‘22 teams. ... The Chiefs' Patrick Mahomes needs three TD passes to break Peyton Manning’s record of 244 for a QB's first eight seasons. Mahomes did not start as a rookie and has played just 111 games while Manning played 128 over that span. ... Mahomes has dominated the Steelers so far in his career, throwing 14 touchdowns without a pick while leading Kansas City to three victories in as many tries. ... Chiefs WR DeAndre Hopkins has an NFL-leading 177 straight games with a catch. TE Travis Kelce is second with 173. ... Kelce has 76 TD catches, tied with Tony Gonzalez for the Chiefs record. Kelce has 79 total TDs, four shy of Priest Holmes' franchise record. ... WR Xavier Worthy has five TD catches, tied for the sixth most by a rookie in Chiefs history. Worthy also has three TD runs, and the eight total is also tied for sixth most in franchise history. ... Chiefs DB Trent McDuffie has intercepted a pass in back-to-back games. He did not have a pick in his first 48 games. ... This is the 12th game in Steelers history to be played on Wednesday and the first since 2020, when a showdown with the Ravens was repeatedly postponed because of COVID-19 issues. Pittsburgh is 5-6 all time on Wednesdays. ... A healthy Pickens will likely give the Steelers passing game a serious boost. QB Russell Wilson is averaging just 167.7 yards per game in Pickens' absence, down from 271 yards per game with Pickens in the lineup. ... This is Pittsburgh's first regular-season game against a team with 14 wins. ... The Steelers have five wins against the defending Super Bowl champions since the 1970 AFL-NFL merger. ... Pittsburgh is 26-12 in Weeks 17 and 18 since the start of the 1990 season, the second-most wins in the NFL over that span behind Green Bay (28). ... The Steelers have won seven straight games and 12 of their past 13 the week following a loss of at least 17 points. ... Pittsburgh leads the NFL with 31 takeaways. and has forced at least two turnovers 11 times. Fantasy tip It might be championship week in your league, so why not turn to a championship quarterback. Mahomes has earned the benefit of the doubt even in a “down” season by his standards and with Pittsburgh missing its top cornerback and the pass rush slowed of late, give Mahomes a start against a team he has toyed with in his career. AP NFL: https://apnews.com/hub/nflCMA calls for investigation into Apple and Google's UK mobile market dominance
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By ALANNA DURKIN RICHER WASHINGTON (AP) — One year after the Jan. 6, 2021 , U.S. Capitol attack, Attorney General Merrick Garland said the Justice Department was committed to holding accountable all perpetrators “at any level” for “the assault on our democracy.” That bold declaration won’t apply to at least one person: Donald Trump. Special counsel Jack Smith’s move on Monday to abandon the federal election interference case against Trump means jurors will likely never decide whether the president-elect is criminally responsible for his attempts to cling to power after losing the 2020 campaign. The decision to walk away from the election charges and the separate classified documents case against Trump marks an abrupt end of the Justice Department’s unprecedented legal effort that once threatened his liberty but appears only to have galvanized his supporters. The abandonment of the cases accusing Trump of endangering American democracy and national security does away with the most serious legal threats he was facing as he returns to the White House. It was the culmination of a monthslong defense effort to delay the proceedings at every step and use the criminal allegations to Trump’s political advantage, putting the final word in the hands of voters instead of jurors. “We always knew that the rich and powerful had an advantage, but I don’t think we would have ever believed that somebody could walk away from everything,” said Stephen Saltzburg, a George Washington University law professor and former Justice Department official. “If there ever was a Teflon defendant, that’s Donald Trump.” While prosecutors left the door open to the possibility that federal charges could be re-filed against Trump after he leaves office, that seems unlikely. Meanwhile, Trump’s presidential victory has thrown into question the future of the two state criminal cases against him in New York and Georgia. Trump was supposed to be sentenced on Tuesday after his conviction on 34 felony counts in his New York hush money case , but it’s possible the sentencing could be delayed until after Trump leaves office, and the defense is pushing to dismiss the case altogether. Smith’s team stressed that their decision to abandon the federal cases was not a reflection of the merit of the charges, but an acknowledgement that they could not move forward under longstanding Justice Department policy that says sitting presidents cannot face criminal prosecution. Trump’s presidential victory set “at odds two fundamental and compelling national interests: On the one hand, the Constitution’s requirement that the President must not be unduly encumbered in fulfilling his weighty responsibilities . . . and on the other hand, the Nation’s commitment to the rule of law,” prosecutors wrote in court papers. The move just weeks after Trump’s victory over Vice President Kamala Harris underscores the immense personal stake Trump had in the campaign in which he turned his legal woes into a political rallying cry. Trump accused prosecutors of bringing the charges in a bid to keep him out of the White House, and he promised revenge on his perceived enemies if he won a second term. “If Donald J. Trump had lost an election, he may very well have spent the rest of his life in prison,” Vice President-elect JD Vance, wrote in a social media post on Monday. “These prosecutions were always political. Now it’s time to ensure what happened to President Trump never happens in this country again.” After the Jan. 6 attack by Trump supporters that left more than 100 police officers injured, Republican leader Mitch McConnell and several other Republicans who voted to acquit Trump during his Senate impeachment trial said it was up to the justice system to hold Trump accountable. The Jan. 6 case brought last year in Washington alleged an increasingly desperate criminal conspiracy to subvert the will of voters after Trump’s 2020 loss, accusing Trump of using the angry mob of supporters that attacked the Capitol as “a tool” in his campaign to pressure then-Vice President Mike Pence and obstruct the certification of Democrat Joe Biden’s victory. Hundreds of Jan. 6 rioters — many of whom have said they felt called to Washington by Trump — have pleaded guilty or been convicted by juries of federal charges at the same courthouse where Trump was supposed to stand trial last year. As the trial date neared, officials at the courthouse that sits within view of the Capitol were busy making plans for the crush of reporters expected to cover the historic case. But Trump’s argument that he enjoyed absolute immunity from prosecution quickly tied up the case in appeals all the way up to the Supreme Court. The high court ruled in July that former presidents have broad immunity from prosecution , and sent the case back to the trial court to decide which allegations could move forward. But the case was dismissed before the trial court could get a chance to do so. Related Articles National Politics | How Trump’s deportations could cost California ‘hundreds of billions of dollars’ National Politics | Auto industry’s shift toward EVs is expected to go on despite Trump threat to kill tax credits National Politics | CDC chief urges focus on health threats as agency confronts political changes National Politics | Trump’s latest tariff plan aims at multiple countries. What does it mean for the US? National Politics | Trump won about 2.5M more votes than in 2020, some in unexpected places The other indictment brought in Florida accused Trump of improperly storing at his Mar-a-Lago estate sensitive documents on nuclear capabilities, enlisting aides and lawyers to help him hide records demanded by investigators and cavalierly showing off a Pentagon “plan of attack” and classified map. But U.S. District Judge Aileen Cannon dismissed the case in July on grounds that Smith was illegally appointed . Smith appealed to the Atlanta-based 11th U.S. Circuit Court of Appeals, but abandoned that appeal on Monday. Smith’s team said it would continue its fight in the appeals court to revive charges against Trump’s two co-defendants because “no principle of temporary immunity applies to them.” In New York, jurors spent weeks last spring hearing evidence in a state case alleging a Trump scheme to illegally influence the 2016 election through a hush money payment to a porn actor who said the two had sex. New York prosecutors recently expressed openness to delaying sentencing until after Trump’s second term, while Trump’s lawyers are fighting to have the conviction dismissed altogether. In Georgia, a trial while Trump is in office seems unlikely in a state case charging him and more than a dozen others with conspiring to overturn his 2020 election loss in the state. The case has been on hold since an appeals court agreed to review whether to remove Fulton County District Attorney Fani Willis over her romantic relationship with the special prosecutor she had hired to lead the case. Associated Press reporter Lisa Mascaro in Washington contributed.
"Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum." Section 1.10.32 of "de Finibus Bonorum et Malorum", written by Cicero in 45 BC "Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" Thanks for your interest in Kalkine Media's content! To continue reading, please log in to your account or create your free account with us.
According to an undergraduate, having pocket money from the Sarawak government eases the financial burden off from students who live far from their families. — Bernama photo KUCHING (Dec 11): The RM1,200 pocket money initiative for Sarawakian university students, announced last month, has been met with enthusiasm by many. However, some of them are questioning its long-term effectiveness and economic impact. Russell Floyd Albert For Russell Floyd Albert, he agrees that the programme offers immediate relief. “This is helpful for us in terms of our budgeting and pocket money. We, the students, can use the money to buy books, stationery items, clothes and other essential things for us to use every day,” the fourth-year student of a public institution of higher learning (IPTA) told The Borneo Post. Adding on, Russell said this incentive would alleviate some burden off the students and help to keep them focused on their studies, instead of having to do part-time jobs to cover their living expenses and also university fees. “Some of my friends said: ‘Abang Jo terbaik!’ (Premier Datuk Patinggi Tan Sri Abang Johari Tun Openg is the best!) as this initiative by him would reduce the burden of living costs and school fees off the students,” he added. Dzul Iqnizarith Zahren Mohamad Yakup Dzul Iqnizarith Zahren Mohamad Yakup, a third-year IPTA student, was also all praise for the aid programme. “Having pocket money from the Sarawak government eases the financial burden off from the students who live far from their families. “We, students, won’t have to stress about how to cover our daily expenses. It supports our social activities too, allowing us to attend gatherings, dine out with friends, or work on group projects without always depending on others. “Ultimately, this assistance helps us lead a more stable and productive life during our studies.” Private university student J. Lee agreed, calling the initiative a good way of promoting tertiary education. “It would help cover postgraduate study costs like printing materials and transportation.” However, not all students view the RM1,200 aid as a major lifeline. Anselm Mcbryan Devric For another IPTA student, Anselm Mcbryan Devric, he praised the initiative for helping those from the B40 (low-income) and M40 (medium-income) families, but also pointed out that RM1,200 would not be enough for the whole year. “At least, it alleviates our burden,” he said. Anselm, a member of his university’s Executive Welfare Committee, also said some of his friends were curious about the procedures involved in the channelling of the RM1,200. “They are eager to know clearer instructions on the distribution process.” Meanwhile, academician Prof Dr Jerome Kueh gave a more cautious perspective. The Associate Professor at the Faculty of Economics and Business at Universiti Malaysia Sarawak (Unimas) praised the ‘spirit of inclusivity’ in the initiative, but at the same time, questioned its sustainability. “This can continue if the state is able to maintain its revenue diversification. “Also, the funds used for students’ cash aid may divert the resources from long-term investments like educational infrastructure or skills programmes,” he said. Kueh also warned about ‘unintended consequences’ such as students becoming too reliant on government aid, or spending the funds on non-essential items. “Without financial literacy programmes, the students may misallocate the money, which would defeat the initiative’s purpose.” The lecturer also highlighted potential inflationary effects, saying increased student spending could drive up prices for food, accommodation and transportation near campuses. In this respect, he suggested that pairing the RM1,200 incentive with financial education could further maximise its benefits. “Teaching students to handle their budget wisely and to prioritise their expenses can foster financial independence and responsible-spending habits.”
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KNOXVILLE, Tenn. (AP) — Nico Iamaleava threw for 209 yards and four touchdowns to lead No. 10 Tennessee to a 56-0 victory over UTEP on Saturday. The Volunteers (9-2) overcame a sluggish start to roll up the impressive win. Both teams were scoreless in the first quarter, but Tennessee found its rhythm. Grad student receiver Bru McCoy, who hadn't caught a touchdown pass this season, had two. Peyton Lewis also ran for two scores. “Once we settled in and did the ordinary things, we had a real good day,” said Tennessee coach Josh Heupel, whose team scored touchdowns on all eight red zone visits. “We started off cold,” said Iamaleava. "We made too many errors. We picked it up as the game went on. “That first play (of the Vols' first series of the game — a long incomplete pass to Squirrel White) we missed for a touchdown. I really want that one back. All you can do is focus on the next play.” Tennessee's defensive line, which had no sacks in last week's loss to Georgia, had four against the Miners. UTEP (2-9) struggled with two missed field goals and three turnovers. It was the second time in Miners coach Scotty Wallen's seven-year coaching career that his team has been shut out. “I thought we took massive steps forward, even though the results weren't what we wanted,” said Wallen. “(Tennessee) is one of the best teams in the country, right there.” Just before halftime, UTEP lost starting quarterback Skyler Locklear with an injury. Backup JP Pickles had trouble getting anything going. “When Skyler went down, that kind of messed with us,” said Miners center Brennan Smith. Tennessee's offense came alive with 28 points in the second quarter. In the final four drives of the quarter, Iamaleava completed 11 of 12 passes for 146 yards and touchdowns to White, Ethan Davis and McCoy. “(That first touchdown) was special for me,” said McCoy. "I promised my mom I'd get into the end zone. I never worried (this season, about not scoring). You have to have faith. The timing will be right for it to happen.” UTEP was the dominant team in the first quarter. Tennessee managed just 37 offensive yards and, thanks to an interception near the end zone and a missed field goal by the Miners, both teams were scoreless after 15 minutes. POLL IMPLICATIONS Tennessee’s convincing victory, coupled with losses by Mississippi and Indiana, should put the Volunteers in a good position when the next College Football Playoff poll is released. The Vols were ranked No. 11 going into this week’s games. THE TAKEAWAY UTEP: The Miners will head into a very winnable game against New Mexico State having won two of their last five games. First-year coach Scotty Walden will try to build on that success in the offseason to help enhance his roster. Tennessee: Even a lopsided win won’t carry much weight where it means the most — in the College Football Playoff rankings. The Vols will have to rely on a convincing win against Vanderbilt next week, a team that has shown a lot of improvement this season, to help their standing for those coveted spots. UP NEXT UTEP: The Miners will finish their season at New Mexico State Saturday. Tennessee: The Vols will finish their regular season at Vanderbilt next Saturday. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballStarmer says ‘bulging benefits bill’ is ‘blighting our society’
Chiefs head to Pittsburgh on Christmas hoping to lock up the top seed in the AFC
Evaluating strategic options for iopofosine I 131 a late-stage clinical program with compelling Phase 2 data and a substantial market opportunity Focusing on advancing radiotherapeutic assets including alpha- and Auger-emitting radioconjugates into Phase 1 solid tumor studies FLORHAM PARK, N.J., Dec. 10, 2024 (GLOBE NEWSWIRE) -- Cellectar Biosciences, Inc. (NASDAQ: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, today announces a strategic update on its clinical development programs for its proprietary phospholipid ether drug conjugate platform that delivers a broad array of therapeutic modalities to target cancers. Due to recent communications with the U.S. Food and Drug Administration (FDA, or the Agency) regarding a confirmatory study to support accelerated approval and the regulatory submission for iopofosine I 131, the Company has decided to pursue strategic options for the further development and commercialization of this product candidate. The CLOVER-WaM study was conducted in accordance with earlier FDA communications from an end of Phase 2 meeting and from a meeting in early 2024, during which the Company was informed that positive results for major response rate (MRR) as the primary endpoint could be acceptable to support accelerated approval of iopofosine I 131 as a treatment for Waldenstrom's macroglobulinemia (WM). Based upon a recent Type-C meeting with the FDA, the Company now believes that a submission seeking accelerated approval would need to be based on the MRR data from CLOVER-WaM and enrollment in a randomized, controlled confirmatory study that is designed to generate data on progression-free survival (PFS). "While iopofosine I 131's positive WM data along with the high unmet medical need for these patients support further investment, we have determined that such a program may best be brought to market by a larger organization with greater resources. Importantly, partnering or divesting this program supports our commitment to providing this potentially life-saving drug to the patients who need it as quickly as possible,” stated James Caruso, president and CEO of Cellectar. "We believe iopofosine I 131 represents a compelling opportunity as it has shown strong efficacy and good tolerability based on our clinical studies. Moreover, the commercial work we conducted demonstrates iopofosine I 131's substantial market opportunity based upon the product profile, which includes off-the-shelf global distribution, orphan pricing and existing unmet medical need.” Cellectar remains confident in the potential of its phospholipid ether drug conjugate platform and the targeted radiotherapies in its development pipeline. Iopofosine I 131's clinical success validates the platform's ability to target cancers and Cellectar will leverage its experience to focus on the development of its earlier clinical programs. Specifically, Cellectar will focus on those assets it believes have the highest therapeutic potential and opportunity for value creation. As highlighted by recent acquisitions and collaborations within the radiopharmaceutical sector, precision isotopes like alpha- and Auger-emitters have emerged as the leading therapeutics of interest. Consequently, the Company will now focus its resources on targeting solid tumors by advancing CLR 121225, its actinium-225 based program, and CLR 121125, its iodine-125 Auger-emitting program into the clinic. Cellectar expects to file Investigational New Drug applications in the first half of 2025 for both CLR-121225 and CLR-121125, which will allow the initiation of Phase 1 clinical studies in solid tumor cancers. Both programs have demonstrated robust in vivo activity, tolerability, excellent targeting and uptake in preclinical solid tumor models. The Company believes this approach will provide an expedited timeframe to achieve safety and proof-of-concept data in patients. The Company's strategic reprioritization will impact all departments and result in an immediate reduction in headcount of approximately 60%, which should be complete by the end of the fourth quarter 2024. The Company anticipates that the implementation of the restructuring will extend its cash runway into the third quarter of 2025. "We are being methodical in our efforts to reorganize the company with the goal of conserving cash while maintaining the flexibility to execute immediate priorities and build for long-term growth and value creation. This reorganization is difficult but necessary for the future growth potential of Cellectar,” said Mr. Caruso. "I want to extend my deepest gratitude to our departing employees for their significant contributions to our work and their dedication to making a difference in the lives of patients.” About Cellectar Biosciences, Inc. Cellectar Biosciences is a late-stage clinical biopharmaceutical company focused on the discovery and development of proprietary drugs for the treatment of cancer, independently and through research and development collaborations. The company's core objective is to leverage its proprietary Phospholipid Drug Conjugate TM (PDC) delivery platform to develop the next-generation of cancer cell-targeting treatments, delivering improved efficacy and better safety as a result of fewer off-target effects. The company's product pipeline includes lead asset, iopofosine I 131, a small-molecule PDC designed to provide targeted delivery of iodine-131 (radioisotope), CLR 121225, an actinium-225 based program being targeted to several solid tumors with significant unmet need, such as pancreatic cancer, CLR 121125, an iodine-125 Auger-emitting program targeted in other solid tumors, such as triple negative breast, lung and colorectal, proprietary preclinical PDC chemotherapeutic programs and multiple partnered PDC assets. In addition, iopofosine I 131 is under evaluation in Phase 2b studies for relapsed or refractory multiple myeloma (MM) and central nervous system (CNS) lymphoma, alongside the CLOVER-2 Phase 1b study, targeting pediatric patients with high-grade gliomas, for which Cellectar is eligible to receive a Pediatric Review Voucher from the FDA upon approval. The FDA has also granted iopofosine I 131 Orphan Drug and Fast Track Designations for various cancer indications. New data from the CLOVER-WaM Phase 2 clinical trial were recently presented in an oral presentation at the 66th American Society of Hematology Annual Meeting and Exposition (ASH 2024). For more information, please visit www.cellectar.com or join the conversation by liking and following us on the company's social media channels: Twitter, LinkedIn, and Facebook. Forward-Looking Statement Disclaimer This news release contains forward-looking statements. You can identify these statements by our use of words such as "may," "expect," "believe," "anticipate," "intend," "could," "estimate," "continue," "plans," or their negatives or cognates. These statements are only estimates and predictions and are subject to known and unknown risks and uncertainties that may cause actual future experience and results to differ materially from the statements made. These statements are based on our current beliefs and expectations as to such future outcomes. Drug discovery and development involve a high degree of risk. Factors that might cause such a material difference include, among others, uncertainties related to the ability to raise additional capital, uncertainties related to the disruptions at our sole source supplier of iopofosine, the ability to attract and retain partners for our technologies, the identification of lead compounds, the successful preclinical development thereof, patient enrollment and the completion of clinical studies, the FDA review process and other government regulation, our ability to obtain regulatory exclusivities, the availability of priority review vouchers, our ability to successfully develop and commercialize drug candidates, competition from other pharmaceutical companies, product pricing and third-party reimbursement. A complete description of risks and uncertainties related to our business is contained in our periodic reports filed with the Securities and Exchange Commission including our Form 10-K/A for the year ended December 31, 2023, and our Form 10-Q for the quarter ended September 30, 2024. These forward-looking statements are made only as of the date hereof, and we disclaim any obligation to update any such forward-looking statements. Contacts MEDIA: Christy Maginn Bliss Bio Health 703-297-7194 [email protected] INVESTORS: Anne Marie Fields Precision AQ 212-362-1200 [email protected]Meet the ex Tory MP who wears starched pants, has never boiled an egg and eats foie gras (but loves a Greggs eclair)
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The 5 best electric vehicle chargers to use at home, according to experts12 tactics America's wealthiest use to save big on taxes, from putting mansions in trusts to stashing fortunes for a 1,000 yearsBusiness process visualization has emerged as a critical tool in enterprise optimization, with the global Business Process Management (BPM) market showing significant growth. As organizations seek to streamline operations and achieve success, professionals like Senior Process Analyst Gokul Ramadoss are implementing structured approaches to workflow documentation using established methodologies such as VISIO diagrams and SIPOC frameworks. Current Industry Landscape The business process management sector encompasses a range of visualization tools and methodologies, from traditional flowcharting to sophisticated digital platforms. BPMN (Business Process Model and Notation) standards have become particularly crucial in regulated sectors like finance, healthcare, and insurance, where process clarity directly impacts operational success. Many organizations are adopting lean management principles in their process documentation, reflecting a broader industry shift toward efficiency and waste reduction. This approach has particular relevance in highly regulated industries where process redundancy can significantly impact operational costs. Practical Implementation in Insurance In a recent large-scale implementation, Ramadoss and his team documented over 150 process flows for an insurance company, incorporating BPMN standards to ensure clarity and compliance. The project achieved notable improvements, reducing manual data entry work by half and decreasing approval process delays by twenty per cent. The Insurance industry is highly regulated but the processes involved can cause redundancies. Through careful GAP analysis, Ramadoss and his team also identified and eliminated redundant processes, improving overall workflow efficiency by eight per cent. Digital Transformation and Process Visualization As organizations undergo digital transformation, process visualization plays an increasingly vital role in application development and in understanding the business process to identify roadblocks. A recent benefits management application redesign project exemplifies this trend, where the re-design meant the current functionalities were enhanced and the navigational aspects of the app were to be changed. As a Solution lead, Ramadoss created Activity diagrams for the Health, Reimbursement and Retirement benefit functionalities within the app. This enabled the business to add value to the Customers and the App rating in general. Activity Diagrams helped map out health, reimbursement, and retirement functionalities, leading to improved user experience and system efficiency. Industry Challenges and Solutions Bringing in the benefits Ramdoss and his team faced several challenges in the business process management sector. Standardization across departments remains a significant hurdle, as does achieving consensus among cross-functional teams. Documentation projects often require balancing multiple perspectives while maintaining clarity in problem statements. Organizations must also navigate the complexities of technology adoption and compliance requirements while implementing new visualization tools. Bringing in the necessary outputs inspired them to bring in the results despite the challenges. Technological Evolution When asked about the trends of the industry, Ramadass acknowledged that it is difficult to predict the future, however, from his experience, he can guess that the industry is moving toward increased automation and intelligence in process documentation. Process visualization technology continues to advance, with new tools offering automated diagram generation, dynamic workflow mapping, and integration with existing enterprise systems. The integration of artificial intelligence with process documentation tools appears imminent, with systems being developed to generate processes based on specific user requirements/inputs. Ramadoss leaves us with this thought that ", With the AI driving the technological revolution, it becomes very important to embrace the finer aspects of the contribution that people make in the betterment of a process. The inputs that leaders provide in an organization ultimately decide the output of a particular process/commodity/product", emphasizing the importance of enabling leaders.YPSILANTI, Mich. (AP) — On a damp Wednesday night with temperatures dipping into the 30s, fans in sparsely filled stands bundled up to watch Buffalo beat Eastern Michigan 37-30 on gray turf. Read this article for free: Already have an account? To continue reading, please subscribe: * YPSILANTI, Mich. (AP) — On a damp Wednesday night with temperatures dipping into the 30s, fans in sparsely filled stands bundled up to watch Buffalo beat Eastern Michigan 37-30 on gray turf. Read unlimited articles for free today: Already have an account? YPSILANTI, Mich. (AP) — On a damp Wednesday night with temperatures dipping into the 30s, fans in sparsely filled stands bundled up to watch Buffalo beat Eastern Michigan 37-30 on gray turf. The lopsided game was not particularly notable, but it was played on one of the nights the Mid-American Conference has made its own: A weeknight. “A lot of the general public thinks we play all of our games on Tuesdays and Wednesdays, not just some of them in November,” MAC Commissioner Jon Steinbrecher said in a telephone interview this week. “What it has done is help take what was a pretty darned good regional conference and has given it a national brand and made it a national conference.” When the conference has played football games on ESPN or ESPN2 over the last two seasons, the linear television audience has been 10 times larger than when conference schools meet on Saturdays and get lost in the shuffle when viewers have many more choices. The most-watched MAC game over the last two years was earlier this month on a Wednesday night when Northern Illinois won at Western Michigan and there were 441,600 viewers, a total that doesn’t include streaming that isn’t captured by Nielsen company. During the same span, the linear TV audience has been no larger than 46,100 to watch two MAC teams play on Saturdays. “Having the whole nation watching on Tuesday and Wednesday night is a huge deal for the MAC,” Eastern Michigan tight end Jere Getzinger said. “Everybody wants to watch football so if you put it on TV on a Tuesday or Wednesday, people are going to watch.” ESPN has carried midweek MAC football games since the start of the century. ESPN and the conference signed a 13-year extension a decade ago that extends their relationship through at least the 2026-27 season. The conference has made the most of the opportunities, using MACtion as a tag on social media for more than a decade and it has become a catchy marketing term for the Group of Five football programs that usually operate under the radar in Michigan, Ohio, Indiana, Illinois and New York. Attendance does tend to go down with weeknight games, keeping some students out of stadiums because they have class or homework and leading to adults staying away home because they have to work the next morning. “The tradeoff is the national exposure,” Buffalo coach Pete Lembo said. “You know November nights midweek the average fan is going to park on the couch, have a bowl of chips and salsa out in front, and watch the game from there.” When the Bulls beat Ball State 51-48 in an overtime thriller on a Tuesday night earlier this month, the announced attendance was 12,708 and that appeared to be generous. There were many empty seats after halftime. “You watch the games on TV, the stadiums all look like this,” Buffalo fan Jeff Wojcicki said. “They are not packed, but it’s the only game on, and you know where to find it.” Sleep and practice schedules take a hit as well, creating another wave of challenges for students to attend class and coaches to prepare without the usual rhythm of preparing all week to play on Saturday. “Last week when we played at Ohio in Athens, we had a 4-four bus ride home and got home at about 3:30 a.m.,” Eastern Michigan center Broderick Roman said. “We still had to go to class and that was tough, but it’s part of what you commit to as an athlete.” That happens a lot in November when the MAC shifts its unique schedule. During the first two weeks of the month, the conference had 10 games on Tuesdays and Wednesdays exclusively. This week, there were five games on Tuesday and Wednesday while only one was left in the traditional Saturday slot with Ball State hosting Bowling Green. Next week, Toledo plays at Akron and Kent State visits Buffalo on Tuesday night before the MAC schedule wraps up with games next Friday and Saturday to determine which teams will meet in the conference title game on Dec. 7 in Detroit. In all, MAC teams will end up playing about 75% of their games on a Saturday and the rest on November weeknights. When the Eagles wrapped up practice earlier this week, two days before they played the Bulls, tight end Jere Getzinger provided some insight into the effects of the scheduling quirk. “It’s Monday, but for us it’s like a Thursday,” he said. Bowling Green coach Scot Loeffler said he frankly has a hard time remembering what day it is when the schedule shift hits in November. Winnipeg Jets Game Days On Winnipeg Jets game days, hockey writers Mike McIntyre and Ken Wiebe send news, notes and quotes from the morning skate, as well as injury updates and lineup decisions. Arrives a few hours prior to puck drop. “The entire week gets turned upside down,” Loeffler said. “It’s wild, but it’s great for the league because there’s two days a week this time of year that people around the country will watch MAC games.” ___ AP freelance writer Jonah Bronstein contributed to this report. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here. AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football Advertisement Advertisement
Elon Musk's X Refuses To Allow The Onion To Take Over Alex Jones' Social Media Accounts"Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum." Section 1.10.32 of "de Finibus Bonorum et Malorum", written by Cicero in 45 BC "Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" Thanks for your interest in Kalkine Media's content! To continue reading, please log in to your account or create your free account with us.
once wanted a “popular uprising” against fossil fuels, but as he has aligned himself with the political right, Musk’s plan for to fight the climate crisis by “accelerat[ing] the world’s transition to sustainable energy.” But as Tesla executives gathered in Palo Alto, California, earlier this year to pitch Musk, the billionaire rejected the idea, to buy computer chips to improve Tesla’s luxury vehicles. The discussions over what was known as the Tesla Model 2 reveal the change in Musk’s approach to the climate crisis as he becomes more and more embedded in President-elect ’s transition team. His change could help boost measures in the nation’s capital against clean energy and possibly even against electric cars. Musk called for a “popular uprising” against the fossil fuel industry in a film released in 2016, the year Trump was first elected to the White House. The world is “unavoidably headed toward some level of harm and the sooner we can take action, the less harm will result,” he told actor Leonardo DiCaprio at the time. “Tesla is working hard to help stop global warming,” he tweeted in 2019, also telling followers that the world was heading toward a “climate change meltdown.” All PowerPoint presentations at Tesla had to include data from former Vice President Al Gore’s documentary pointing to rising carbon dioxide in the atmosphere to remind employees of Tesla’s goals, according to But the information from the film is no longer required in the presentations. The climate crisis also appears to have dropped significantly as a priority for Musk. In August, he took part in a live stream on X with Trump, in which he said, “We don’t need to rush” to solve the climate issue. He also said that efforts to address climate change should take place without “demonizing people” and that “It’s not like the house is on fire immediately.” While those close to Musk told that he still thinks the climate crisis is a problem, he now believes that the risks of climate disasters have been overblown. “Global warming risk is overblown in the short term, but significant in the long term,” he wrote on X in May last year. Five people told the paper that his views have been affected by a right-wing media universe online and from his time in Texas. More recently, he’s grown fond of technological solutions to the climate crisis, including nuclear power and carbon capture. He’s now rarely seen talking about the climate crisis as a looming problem. Now, he is more focused on seeing robotics, AI, addressing population decline and getting to Mars as more important to human survival. Some executives at Tesla have left the business amid Musk’s change of heart, and Trump has campaigned on ending the electric vehicle tax credit which has been a boost for the company’s business. Musk has also noted that the tax credit will have to be removed. But he’s set to argue to Trump that he should help all his business ventures, such as and Starlink, not simply focus on Tesla, one person told The change in Musk’s views has been taking place over the course of years, five people told the paper, adding it comes after fights with environmentalists, a strained relationship with the Biden administration and a shift to the right in his views tied to the Covid-19 pandemic. “He used to be a Democrat who believed everything he was told was true about this,” one person told the paper. “And now he thinks for himself and realizes, yes, climate change is real, but it’s not nearly among the top problems right now.” In 2020, the pandemic began to change Musk’s views as lockdowns forced the closure of Tesla’s main plant. Musk began tearing down mask mandate posters, noted. Musk revealed in May 2020 that Tesla headquarters was leaving California. Musk’s transgender daughter Vivian Jenna Wilson received gender-affirming care around that same time, with those close to Musk saying that he was distraught at her transition. The pandemic and his daughter’s gender transition both pushed him to turn against Democrats and everything they stand for, including their views on climate change. “Anything the left saying [was] conspiratorial and bulls***,” one person told The following year, Musk grew irate after Tesla wasn’t invited to an EV summit at the White House. Musk began discussing climate issues with others who held skeptical views of climate predictions, such as Palantir co-founder Joe Lonsdale, and Florida Governor Ron DeSantis. Musk associate Robert Zubrin told the paper: “He decided he would join this camp, and this was more important than the whole climate cause. He decided to go all in,” Zubrin said. “And I guess in one sense, that is characteristic Musk – When he decides to do something, he goes all in.” Last year, Musk met entrepreneur and 2024 primary candidate Vivek Ramaswamy. The duo is now in charge of the outside commission the Department of Government Efficiency, or DOGE, . In a taste of what’s to come, last month Musk reposted the names and titles of four people with low-profile climate-related jobs in the government, prompting negative attention with at least one of the four women removing her social media accounts.
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