Amber Group's Subsidiary Amber DWM Holding Limited and Nasdaq-Listed iClick Interactive Asia Group Limited Enter into a Definitive Merger Agreement
LOCAL LEGENDS: Canadian Linen's journey to quality, community and careA new study published by the Anti-Defamation League (ADL) reveals significant workplace discrimination against Israeli-Americans and Jews in the U.S. According to the research, Israeli-American job seekers are required to submit 39% more applications to receive the same number of positive responses as their Western European counterparts applying for identical positions. For Jewish-American job seekers, the figure is 24% more applications. The city with the most significant disparity for Israelis is Seattle, the tech and coffee capital, home to major companies like Amazon, Microsoft, Costco and Starbucks. The study, conducted by Dr. Brian Tomlin, an economist at California State University Channel Islands (CSUCI), was based on an experiment in which 3,000 job applications were sent for administrative positions. The applications included identical resumes, except for details revealing the candidate's origin— whether they were Jewish, Israeli or Western European. The results show that cultural or religious backgrounds can be a significant barrier to employment opportunities, even when qualifications are identical. In addition to geographic differences, the study found that how information was presented on resumes had an impact. For instance, resumes with names strongly associated with Jewish or Israeli identities (e.g., "Lia Abraham" and "Rebecca Cohen") led to clear disparities in responses. Other factors, such as the use of Hebrew as a second language or listing an Israeli-associated workplace, contributed to the discrimination. The study also revealed local variations. Israeli-Americans received notably better responses in cities like New York and Philadelphia, where their positive response rates were similar to or slightly higher than Western European candidates. However, researchers note that the differences were not statistically significant, making it unclear whether this was due to genuine openness or random employer patterns. In contrast, Seattle showed a particularly negative disparity, where Israeli candidates received only a 6.8% positive response rate, compared to 23.1% for Western European candidates. Researchers suggest further study is needed to understand the underlying causes. 3 View gallery In Seattle, only 6.8% of Israeli candidates received positive responses to their job applications ( Photo: Shutterstock ) In most cities examined, Israeli-American and Jewish-American candidates faced some level of discrimination, though its severity varied across regions. In cities with higher unemployment rates, the disparities were more pronounced, likely due to increased competition for jobs, leading to more stringent candidate screening. Additionally, in cities with higher average salaries, Israeli and Jewish candidates were more likely to be rejected, hinting that employers in those areas tend to be particularly selective. These findings suggest that a combination of high competition and high wages may exacerbate discrimination against certain groups, even when candidates' skills and experience are equivalent. Cities with the most noticeable bias against Israelis and Jews included Atlanta, Baltimore, Portland, Minneapolis, Washington, D.C., Chicago, Denver, Houston, Miami, Phoenix and San Diego. On the other hand, cities where Israelis and Jews were treated more equally or even favorably included Los Angeles, Austin, Dallas, Boston, Trenton, San Francisco, San Antonio and Las Vegas. 3 View gallery Miami ( Photo: Shutterstock ) According to Tomlin, the data shows that Jewish and Israeli candidates are forced to prove themselves beyond typical expectations but are not treated fairly. "It is difficult, if not impossible, to prove discrimination in the job market—especially when it comes to Israelis or Jews, who are not defined as an ethnic minority group protected in the U.S.," he said. "However, the findings show that people lose job opportunities because of their identity, not due to a lack of qualifications." The study also found that some employers who identified Israeli candidates responded in Hebrew or made direct references to their Israeli background, such as offering greetings like "Good luck!" In contrast, no similar responses were recorded for Jewish or Western European candidates. The researchers noted that this indicates employers view an applicant's Israeli background as significant, either positively or negatively. Get the Ynetnews app on your smartphone: Google Play : https://bit.ly/4eJ37pE | Apple App Store : https://bit.ly/3ZL7iNv The study underscores a broader trend of increasing antisemitic incidents in the U.S. According to the ADL, more than 3,000 antisemitic events, including physical assaults, property damage, and verbal harassment, were recorded in the first three months of 2024 alone. Jonathan Greenblatt, CEO of the ADL, called the findings "unprecedented evidence of antisemitic discrimination in the job market." He added, "In addition to the rise in antisemitic incidents and beliefs, the study highlights the urgent need to combat prejudice against Jews and Israelis in the workplace. Beyond the legal aspects, organizations must recognize their social responsibility and ensure an inclusive work environment." >Canada's Trudeau returns home after Trump meeting without assurances that tariffs are off the table
The great British high street is on life support. Two years of pandemic restrictions, the rise of working from home, soaring energy prices and rising business rates and corporation tax have created the perfect storm. That said, its decline pre-dates the pandemic. Online retail has had a detrimental effect for years, turning and forcing others to reinvent themselves around services – think coffee shops and beauty salons – rather than shopping. Your typical 21st-century parade now consists of a Starbucks, a Greggs, a Specsavers, and a sorry assortment of bookmakers, phone repair shops and pound stores. But there are beacons of light piercing the gloom: thriving high streets in handsome towns that retain a healthy selection of quirky and independent businesses, giving shoppers a fine reason to escape the tyranny of Amazon. Here are 20 of the country’s finest, chosen by our UK destination experts. With its meandering streets and blush-sandstone castle wrapped in a loop of the Severn, Shropshire’s compact county town is ideal for wandering and window shopping. The covered market was voted the country’s best in 2024. But it’s hard to beat Wyle Cop, a curving, climbing high street lined with 39 listed buildings, ranging from medieval half-timbered to Victorian ornate. Henry Tudor stopped in one of them (now the ), before the Battle of Bosworth in 1485; Charles Darwin (Shrewsbury’s most famous son) liked to drink in its coaching inns. Today, Wyle Cop is said to be the longest run of independent shops in the country. Fashion stores and are great for one-off finds, while uses textile waste to make gorgeous new creations. Foodies should forage in , where hams dangle from the rafters and counters are crammed with cheese. will supply any pots, pans or plates required to feed extra Christmas guests. For gifts, is stocked with cheery, colourful things – happy socks, star-spangled throws. It also hosts creative workshops after hours, allowing local makers to showcase their skills: upcoming events include sip-and-paint classes and charm-necklace making – a good way to get out for some creative stimulation during the darker months. For artistic inspiration, visit art gallery’s winter exhibition. At the foot of Wyle Cop, the 16th-century has a two AA Rosette restaurant. – past winner of the ‘Best National Wine Shop’ – hosts tastings in store, and runs a tapas bar next door. The term “retail therapy” was never so apt. Because Norwich’s Royal Arcade is a pretty near perfect prescription for those who love to shop, but are allergic to the garish American-Mall-ification of the experience elsewhere. Opened in 1899, it sits at the very centre of “the fine city” yet is a haven from it. The Art Nouveau tiles that cover its walls were designed by WJ Neatby, who also dreamed up those in Harrods Food Hall. Decorative columns and stained-glass windows frame rows of identical, bowed mahogany shop fronts. Inside, independent boutiques tempt. Foodies will find plenty over which to salivate at – an award-winning patisserie. Children will adore , a treasure-trove of a toy shop that has been in Norwich since 1883. Men are catered for at – a super-chic male grooming and fragrance shop, all handmade in Norfolk – and women at , which sells its own vegan, organic and super-covetable cosmetics. The hosts workshops in which you can make your own tipple under the tutelage of an expert distiller. Named after the Norfolk word for “munch”, two-storey food hall opened in 2023 to showcase the region’s best independent cooks. Accordingly, upstairs hosts – among others – (from up on the North Norfolk coast), and taco bar (from the brains behind firm Norwich favourite ). Downstairs, there’s a fondue and wine bar, plus a coffee and cocktail joint. Belper is doing something right. This former powerhouse of the Industrial Revolution has successfully reinvented itself for the 21st century: it’s the only place in the country to have won the Great British High Street’s High Street of the Year award twice and is lauded for its community engagement and proactive association of independent businesses. “I love Belper,” says local chef Leo Hill. “I’ve watched it fight through recessions, win awards, help businesses grow and also band together to pull all of its people through the pandemic. The sense of community makes it stand out from most other towns.” Sitting handsomely in the Derwent Valley, Belper is only 11 minutes by train from Derby. Combine shopping here with a bracing walk – perhaps to the nearby, and excellent, . is something of a magic kingdom, full of sparkly delights – think glittery toadstools, giant gingerbread houses and circus-giraffe baubles. is hygge in retail form, with a cosy-cool array of Scandi blankets, linens and knick-knacks. Belper has several indie clothes stores – stocks heritage-inspired menswear, designed and manufactured in Britain. For an eclectic rummage, visit , where 40-plus retailers sell everything from old vinyl to vintage clobber. Try the pizzas at , which are made using ingredients foraged locally or sourced from Derbyshire suppliers. For homemade cakes and the best all-day breakfasts, head to . Bury St Edmunds is a fantasy Suffolk market town of Georgian squares, wonky medieval walls and prettily lit shop fronts that entice you like well-wrapped gifts. As Christmas creeps up, neo-Gothic lifts moods not only with glimpses of its kaleidoscope-like, fan-vaulted ceiling, but with festive events from wreath-making workshops, Christmas markets, concerts and candlelit parades. Over at the , Britain’s last-surviving Regency playhouse, a performance or panto comes with a shot of nostalgia. Post-shop, bundle up for a crisp walk through the , hugging the banks of the River Lark. Here among the herb and water gardens, you’ll find the enigmatic ruins of a once-splendid Benedictine abbey and impressively intact medieval ruins like the Great Gate and gargoyle-encrusted Norman Tower. Pilgrims once trudged here to visit Anglo-Saxon king Edmund the Martyr’s shrine. There’s still plenty of indie spirit in Bury – explore the backstreets and you’ll find gifts that go way beyond bog-standard stocking fillers. On St John’s Street, pop into for vintage clothing and old-fashioned service to match, and for one-off records. Closer to the cathedral, find moody Suffolk landscapes to grace a mantlepiece in the on Angel Hill, and a tasteful array of gifts (from plant-based Chalk cosmetics to ceramics, jewellery and Jellycat toys) at on Abbeygate Street. Food and drink? Head to Hatter Street for artisan cheeses at , or sip an espresso while choosing the perfect bottle of wine at . Bury’s twice weekly market (held on Wednesday and Saturday) is a feast of seasonal local produce – fruit and veg, fish and meat, pickles, chutneys, honey, you name it. Don’t rush off. Drop your bags at , an ivy-swaddled boutique stunner that swirls in history and romance, especially if you opt for one of Ivy View Copper Rooms with free-standing copper bathtub. Dickens sojourned in this former coaching inn, immortalising it in , and it hit screens in the 2020 film . Go for a Dickens-inspired Pickwick Afternoon Tea, with Victorian faves like ‘butterfingers’, hot sausage and mustard, and buttermilk scones (there’s also a children’s version). Or book dinner in The Eaterie to try the spot-on beef and red wine ‘Pickwick Pie’. Otherwise, snag a table at slickly intimate for hyper-local food with a Mediterranean twist in a former bus shelter. Or book well ahead for Michelin-starred, gorgeously rustic for inventive Moorish-inspired cooking that you’ll be raving about long after the tinsel comes down. A pint, you say? Squeeze into The Nutshell, a cheery, picture-plastered Victorian boozer that is Britain’s smallest pub according to Guinness (check out the mummified cat). Catnip to Instagrammers but also unexpectedly good for independent shops, the elegant yet whimsical double-decker curve of colourful Victoria Street (historically known as the West Bow) picturesquely connects the Grassmarket and the Royal Mile. It was designed by architect Thomas Hamilton in Flemish Revival style, although India Buildings on the south side of the street (now a swanky Virgin Hotel with a great cocktail bar) is pure Scottish Baronial. The upper terrace is still home to the Quaker Meeting House and curiously, a shop selling Masonic regalia. Widely considered J.K. Rowling’s inspiration for Diagon Alley, it is thought that the home of Thomas Weir (the “Wizard of West Bow” executed for witchcraft in 1670) was here, although a more benign wizarding link might be to the much-mourned Cresser’s brush shop. Virtually unchanged from its 1873 opening to closing in 2004 it sold every incarnation of brush imaginable, including made-to-order brooms. Harry Potter fantasy-themed shops will keep any youngster happy, leaving adults free to explore , then the Whisky Shop next door. Continue to ’s two shops selling luxurious country clothing, both off-the-peg and bespoke. For trendier tartan, there’s for tweed handbags, gloves and footwear. Passing the sword-maker on the left, cross the Grassmarket at the bottom for mouth-watering , , ’s vintage clothing and . Sunny day? Head to the terrace at . Or try its sibling restaurant just below; both serve good food all day and into the evening. Sir Walter Scott was certainly a fan: he called Stamford “the finest stone town in England”. More latterly, others have agreed: in 1967 this cluster of medieval and Georgian architecture became the first designated conservation area in the country. It’s a great hub for shopping: the high street is pedestrianised and many of the town’s 600-odd listed buildings house fabulous independents – speciality food stores, cafes, antique shops, clothing boutiques. The Lincolnshire limestone looks especially lovely in low winter sunshine or shimmering with fairy lights. sits on the outskirts. The Elizabethan house, which you may recognise from playing Windsor Castle in The Crown, is closed for winter but its Orangery serves festive afternoon teas. is the place for furniture, accessories and gifts, with a good seasonal selection – the Fairtrade robin hand warmers look especially appealing. Long-standing indie clothes shop is the place for thoughtfully-curated fashion; the Vogue Williams burgundy sequinned skirt would be perfect for festive party season. For an elevated Christmas cheese board, head for . Run by Mark Hulme and Perry James Wakeman – the UK’s first-ever ‘Affineur of the Year’ (that’s someone who knows A LOT about cheese) – the store champions the best of British. The Christas Edition Mystery Cheese Box will pride a festive surprise. The George is an institution; its speciality is roast sirloin of British beef, carved at your table from the silver trolley. For cocktails and modern fine dining, head to the . Chester was voted the world’s best-looking city after a study examined the golden ratio of its architecture. It’s certainly a beauty. A walk along its four, half-timbered main streets is like a promenade through 2,000 years of history from the Romans to the modern day. Tudor buildings, Georgian townhouses and statement Victorian centrepieces complete a history-spanning backdrop to mooching, gift hunting and hot-chocolate supping. Compact, bustling and packed with independent shops, Chester is big on festive atmosphere as well as rich with heritage. Look out for Christmas market on Town Hall Square from November 15 and Sleeping Beauty, the Christmas show at the Storyhouse arts centre from December 6. Or book a themed walking tour to explore lesser-known attractions, such as the café-bars of medieval Godstall Lane or the haunted pubs of Lower Bridge Street. No wonder Chester beat Venice to the top spot, and Chester now even has its very own Monopoly board. Chester’s unique, split-level shopping arcades, The Rows, date from the Middle Ages but are today home to interesting independent traders. Try Harriet & Dee on Watergate Row North for cards, gifts and toys, or fashion boutique Nichols & Co on Bridge Street Row for jewellery, candles and vintage pieces. Outside the Rows, hidden-gem locals indies include The Cheese Wedge and Amblongus Books for antiquarian treasures. There’s also a scattering of pop-up art galleries for souvenir images of the city and . The food court in New Chester Market offers all-day variety; otherwise, Pars Khave has tasty Turkish treats on Watergate Row and Arthouse Café on Bridge Street serves its chai lattes in a medieval crypt. The Brewery Tap has craft ales and hearty pub food to round off your visit. Totnes has become a bit of a cliché through its reputation for independent shopping, green thinking and “alternative” lifestyles. Its self-proclaimed status as a “Transition Town” – keen to wean itself off fossil fuels – is more a mental state than a political force, but Totnesians are proud defenders of the right to look and behave differently. The high street has more Tudor buildings than many cities, and it’s worth pausing on the hike up its steep incline to take in the facades, architectural features and window displays. St Mary’s Church is imposing and has a wonderful rood screen. There are some lovely walks nearby, including to the Dartington Estate and all along the Dart River; Vire Island is a nice place to sit back and relax when your shopping’s done. For stylish women and men’s fashions, is hard to beat; the lovely staff serve coffee (and even whisky) to waiting guests. record store at the top of town stocks a small but carefully curated selection of indy, ambient, classic rock and electronica vinyls. on the Rotherfold (the old market square for cattle-trading) opposite Drift is tiny but has some quirky gifts and décor items. There are dozens of independent shops along the one main street – including bookshops, fancy dress hire, ethnic clobber, design items, art galleries, instrument shops – so do some browsing before getting down to business. is very Totnes, sourcing produce locally and foraging for some items in the surrounding countryside. The £80 tasting menu features “hedgerow beignets” and seaweed-based sauce; wine pairing is £50. is a great gastropub, with rooms, and the down on the Plains (at the bottom of the high street) is the place to go for flat whites and gluten-free cakes. Deep in the Brecon Beacons, where hedgerows sweep up the hills and proper peaks are but a muddy boot stomp away, this cute-as-a-button town won Best High Street of the Year in 2018. Locals have staunchly resisted the tidal wave of chains and here the great British high street lives on, with a butcher, baker and a sprinkling of independent shops from delis to art galleries and bookshops. A vision of pastel-painted Georgian loveliness, Crickhowell feels especially festive in the blue of dusk, when there’s a nip in the air and the lights are aglow in its houses and pubs. Pleasingly old-school, it has changed little since Tolkien hung out here on his holidays (word has it the village inspired Crickhollow in The Hobbit). And it is fantasy stuff, especially if you ramble up to flat-topped, 451m Crug Hywel, where its Iron Age hillfort and views reaching for miles across the Black Mountains provide perk on even the drizzliest of days. Pleasingly old-school, it has changed little since Tolkien hung out here on his holidays (word has it the village inspired Crickhollow in The Hobbit). And it is fantasy stuff, especially if you ramble up to flat-topped, 451m Crug Hywel, where its Iron Age hillfort and views reaching for miles across the Black Mountains provide perk on even the drizzliest of days. Crickhowell is tiny, but you’ll nevertheless stop every few metres to nose around its shops. Dip into for one-of-a-kind Welsh paintings, prints, jewellery, ceramics, glass and sculpture, and , the indie bookshop dream, with a cracking café out the back. The spices up stockings with home-smoked and hill-sourced treats, from oak-smoked salmon to fancy pâtés, all-Welsh wines, craft beers, charcuterie, honeys, preserves and cheeses (pick up a smoky Pwll or Blaenavon Dragon’s Breath cheddar). You can’t miss , a glorious 600-year-old coaching inn with roaring fires and low beams. Go for a pint and well-done pub classics prepared with locally sourced produce, or nab a table at on the banks of the River Usk for a warmly rustic atmosphere and menu with season-led stunners like crab scotch egg with brown crab mayo and fennel, and dry-aged sirloin with oxtail, bone marrow sauce and triple cooked chips. The shops may have new names, but the look and feel of Fore Street has changed surprisingly little over the last century. Pretty slate-hung shops line the winding cobbled street and serve both locals and tourists. This is a proper mixed-purpose main street with a Post Office, the excellent St Ives Bakery, a bottle shop, a bookseller and leather goods and clothes shops to suit all ages and budgets. Most are independently owned and the many galleries reflect Penwith’s artistic heritage. at number 14 lets you make and label your own flavoured gin in a mini copper still and sells its delicious botanicals range. at number 28 is the best of the town’s art galleries. This is the place to come for stylish outdoor clothing. Cornish eco-brand has a store at number 10 and sells top-class gear from Australia and Japan, at number 30. Next door but one, at number 34, has been selling affordable fishermen’s wool jumpers and sheepskin slippers since the 1980s. For fresh Cornish seafood, is the place to go: owner chef Dorian Janmaat hails from Andalucia and serves authentic tapas. If you prefer a steak or a burger visit ; head upstairs for a window table and a grandstand view of the harbour. For coffee, cake and ciabatta sandwiches drop in at The Yellow Canary. Clitheroe is one of central Lancashire’s oldest towns. Established in the 12th century as a Norman stronghold and sited on a Roman Road, it hasn’t suffered quite the same cycles of boom and bust as nearby industrial centres. The castle ruins sit atop a hill inside the main park, affording awe-inspiring views over Bowland and Pendle Hill. The high street runs from the edge of the park, up and then down, and is full of shops and cafés, historic inns and hair salons – all well used by locals and popular with Lancastrians from outside the Ribble Valley and folk from West Yorkshire. Small but busy enough to sustain independent retail, Clitheroe is a lovely place to explore for itself and a great base for walking and cycling holidays. is a well-stocked, old-school, second-hand bookshop with a good number of local history and specialist books as well as hardback fiction. Outdoor clothing specialist has a great selection of hats, winter wear, wellies and “town and country” fashions. Clitheroe Market, as old as the town, operates Tuesday, Thursday and Saturday, and is good for fruit, veg, pies and samosas. Booths supermarket, the “Waitrose of the North”, is just opposite. New cocktail bar has great drinks and Italian nibbles. is a good example of how to repurpose former industrial buildings, with a smart dining and deli area, good wines and a pub housing old machinery. (cash only) does good coffee and cakes. Booth’s new café, , is also good for pastries and lattes. Petworth is picture-perfect. With its well-preserved Tudor and Georgian houses arranged along winding, chain-free streets, the market town oozes olde-worlde atmosphere. No surprise that Bridgerton crews have filmed here. JMW Turner was also keen (he painted in Petworth a lot in the 1820s), and art is still a big deal. The town’s hosts first-class exhibitions, currently focusing on Lee Miller and Picasso. Meanwhile, the National Trust’s Petworth House boasts one of the country’s largest art collections. There are many great independents to browse, from the Petworth Bookshop to Guilt Lingerie. Petworth is the only town outside London to have more than 30 arts and antiques dealers within a one-mile radius. Start at , where many gather under one roof, purveying vintage lace, gentleman’s paraphernalia and more. also sells antiques, plus modern pieces and homewares – the 1920s-style Madison Coupe glasses look just the thing for a happy new year. Award-winning deli, shop and bakery the stocks a cornucopia of artisanal treats. For high-end dining, majoring on quality local produce, head for the . is a historic coaching inn with cosy rooms, open fireplaces and good West Sussex menu, focused on local produce. With its narrow, age-worn streets and the powerful presence of the Minster in all its Gothic glory, there are few finer places for a day of shopping than York. Stonegate, with its hotch-potch of buildings – thick-walled medieval, half-timbered Tudor, red-brick Georgian and a dizzying array of window styles jutting out at first-floor level – lies directly above the Via Praetoria, the main route in Roman-age York. It continues to be a prime address, leading to the Minster which seems to fill the sky at the eastern end. Barley Hall, a medieval townhouse, was the home of Alderman William Snawswell, goldsmith and Lord Mayor of York, in the 15th century. Unbelievably it was hidden behind offices and only discovered, and restored, in the 1980s. The malevolent red devil face above number 33 indicated the building was once a printers – “printers devils” carried the hot metal type – while the street-spanning timber beam emblazoned with “Ye Olde Starre Inn” is an 18th-century bullish piece of advertising that still directs customers to the hostelry tucked down a snickleway (narrow lane). , a year-round Christmas shop, has everything imaginable, from snow globes and nativity scene figures to gingerbread earrings and snowman pillows. has offered Yorkshire-woven wool products for more than 180 years. As well as tailored jackets and trousers, you can find scarves, hats and gloves. sources and blends a wide range of brew that should satisfy the fussiest of palates. At , choose from one of three colourful themed rooms and a menu of brunch favourites or a full-on afternoon tea. , stepping distance from Stonegate down Coffee Yard snickleway, serves up colourful North African dishes such as Algerian merguez cassoulet and shakshuka. Chipping Campden is a Cotswolds showstopper of golden stone and gracious houses. Its high street is almost implausibly exquisite, a parade of dreamily handsome properties built by well-to-do wool merchants between the 14th and 17th centuries. At its centre is a 400-year-old market hall with arched open sides and a floor marked with the patina of time and trade (“Chipping” derives from the Old English word for market). The town became one of the richest places in the country, but it has another major story, too: in the early 1900s it became the headquarters of the Guild of Handicraft in the Arts & Crafts movement – and it continues to have a gently (and palpably) arty heartbeat today. Campden, as it’s known by locals, is on a network of minor roads going nowhere much, so it’s rarely engulfed by tourist coachloads. A steady trickle of savvy visitors comes for the wonderful mix the town offers – of beauty, history and enticing little stores. Head to for a tempting array of gifts, soaps and accessories. deli is where to go for flavours of the Cotswolds, from honey to fudge, ale and Cotswold Distillery Gin. offers such fabulously displayed dining and kitchen ware it looks like an art gallery. For a treat, stroll around the corner to the Old Silk Mill housing art cooperative store. Neat little is ideal for lunches of salads and toasties. Much-loved locally, offers great charm along with dishes such as vegetable moussaka and beef stifado. For historic atmosphere and an exotic touch head to the , dating from the 14th century and said to have been a refuge for the future Charles II on the run in the Civil War. Here you can tuck into hearty pub classics or an aromatic curry created by the Sri Lankan chef. The weather can be wicked and the storms wild, but Aberystwyth has its own moody magic in winter, with booming surf adding drama to a day of shopping. When you’re done browsing its boutiques, delis, galleries and craft shops, you’ll find some of the hottest places in Wales to eat and drink, not to mention two-Michelin-starred , with Gareth Ward at the helm, just a 30-minute drive up the road. Climb the hill for a post-shop culture shot. The harbours millions of rare and precious tomes and manuscripts, the medieval Nanteos Cup (a Holy Grail contender) and a terrific gift shop. Next door, the has Christmas crafts and performances. Back in town, walk to the Victorian pier to catch a smouldering sunset and starling murmurations arcing and swaying in the sky. Some 50,000 of these migratory birds roost here in winter. Kick off a festive shop at dinky, retro Italian deli , where Mario (from Milano) will sell you the finest salumi, Sardinian pecorino and Sicilian sweets. Nearby, is a rambling attic of gifts (from gladstone bags to kid-leather gloves), while brims to the rafters with second-hand titles. Swing over to for local beers and gins, or for upcycled arts and crafts in colours and patterns that pop (its lampshades are incredible). ’s sunny vibe, small plates menu and carefully-curated vinos and vermouths instantly transport you to a Madrid backstreet. Here tapas come with a Welsh twist, such as baked octopus served with olive oil, paprika and Halen Môn sea salt. Or swing by cosy, bohemian-flavoured to assemble your own Middle Eastern feast, with the likes of Lebanese chicken pitta with garlic mayo, cumin-fried whitebait with lemon, and courgette fries sprinkled with sumac. Sitting between the River Tweed and the Eildon Hills, Melrose has a mighty 12th-century ruined abbey and the high street of your nostalgic imagination. There are few chains here. Instead, it has butchers, bakers and candlestick-makers (well, Natural Crafts sells candle-making kits, along with other art supplies). It also has a greengrocer, a fishmonger and , well-stocked with handmade festive chocolates and Scottish tablet. Sir Walter Scott loved this area too, so much so that he built his home just west of town. Combine Melrose with a visit to see Scott’s Abbotsford. stocks 100-plus whiskies, plus boutique wines, local craft beers and Borders gins; tastings are held in its cafe bar. Pick up local-made textiles, ceramics and homewares at . Feeling nippy? is based in Melrose – its showroom is in a fine Georgian townhouse, near the main square. Pop in to browse hand-crafted Scottish-made woollens, including limited editions and one-offs – the ultimate Christmas jumper. The Country Kitchen Deli stocks lots of goodies, perfect for party nibbles – pick up macarons, dipping oils and chocolate and cranberry fudge; it also sells a wide range of world cheeses (Scottish blue, Spanish goat, Norwegian brown), all best with a loaf of slow-fermented sough dough from bakehouse next-door. creates delicious dishes from local, seasonal and sustainable ingredients. Or walk over the river to the in Gattonside, one of the smartest restaurants in the Borders. With its high street parade of wonky, half-timbered, pastel-painted Tudor houses (300 of them listed), the medieval Suffolk wool town of Lavenham is ridiculously lovely at any time of year. And if it feels like a film set, it is – the timber-framed Guildhall starred in the 2010 film Ha , and the town’s pretty lanes were the backdrop for the BBC drama . Lavenham’s good looks attract independent minds, with a sprinkling of shops and boutiques doing a brisk trade in everything from antiques to pottery, vintage teddy bears to bespoke jewellery. And during winter, when the town twinkles with lights, the town is a ready-made Christmas card. When you tire of shopping, spare a moment to visit the magnificent St Peter and St Paul, a church of cathedral-like proportions in Late Perpendicular Gothic style. On the fourth Sunday of the month, , held at the village hall, is one of Britain’s very best. Buy your Suffolk pork, Longhorn beef, venison, and homemade cakes, preserves, chutneys, honeys and cheeses here. has a thoughtful selection of local paintings, ceramics, prints, jewellery and sculpture, or try for cards, decorations, homeware, candles and one-of-a-kind gifts like handcrafted Moroccan babouche slippers. The most unmissable is tremendously festive , creaking with history and medieval beams, and with fireplaces and Christmas trees aglow. Dinner in its minstrels’ gallery is a season-spun feast of British flavours with a whisper of French finesse, with wintry mains like venison with braised and puréed salsify and garlic mash potato. Or if you just fancy tapas or a sharing platter with a nice glass of red, head to , a snug modern-rustic pub in a Grade II-listed building. Opposite the Guildhall, does a proper old-fashioned afternoon tea. Most visitors to Conwy are heading to its 13th-century castle, built as a symbol of military power by Edward I. The compact yet bustling high street is, however, just a short walk from the castle’s imposing towers and contained within the medieval town walls, both with World Heritage status. The town celebrates Winterfest on December 9 with an evening parade of street entertainers and a torch-lit procession of knights in armour. The main street is busy with high-summer day-trippers but retains a sense of Welsh with lots of independent retailers, such as book and gift shop Hinton’s, and great places to sample the award-wining local flavours. Having cruised the high street, cross over Castle Street and walk down to the quayside for a selfie outside the smallest house in Wales, an old fisherman’s cottage, and blast of sea air. It’s a short drive through the scenic Conwy Valley to Bodnant Gardens, an all-seasons haven of nature and wildlife. Dylans is a fabulous deli with an adjoining restaurant, part of a Welsh foodie group, while bottle shop Vinomondo has a selection of Welsh beers, wines and spirits to sample – try a Dark Side of the Moose ale from the Purple Moose Brewery. Just off Lancaster Square at the top of High Street, Baravelli’s is an artisan chocolatier, formally featured on TV’s Extreme Chocolatiers. The Erskine Arms is a cosy pub for real ales and good-quality food with a Welsh twist. For afternoon tea, Upstairs at Anna’s is stylish tearoom on the upper floor of a heritage building, while the Conwy Bakery across the road has take-away treats, including traditional Welshcakes and (a fruit bread) for a souvenir taste of Wales. Textile township turned right-on rural redoubt – formerly for hippies, these days more for hipsters – Hebden Bridge is a lovely place to spend a day or two. Surrounded by moorland, close to a river and a canal, beneath pretty Heptonstall, and well-placed for walks on the Pennine Way and its branches, it’s also on the railway line between Manchester and Halifax. Stone terraces climb up its steep sides, and the road-free centre is often busy with pub-goers and daytrippers. Twenty-five years ago, retail meant a scented candle, jos-sticks, crystals and clogs. Today, the West Yorkshire village packs a lot of places to eat, drink, shop and browse into a relatively compact area at the bottom of the steep cleft in which it sits. Toy shop stocks everything fun, from skateboards and board games to juggling kit and kites. Antiques and bric a brac are big business in mooch-friendly Hebden Bridge. Period furniture, vintage clothing and smaller items can be rummaged for at , – in the former police station – and the . – an outpost of Todmorden’s much-loved Crumbly Cheese – has cheeses from all over but is great if you’re after options from West and North Yorkshire. There are lots of cafes to choose from. , on Albert Street, is run by two cycling and outdoor enthusiasts. Leeds-roasted North Star coffee is served from behind the plywood counter, along with pastries and cakes. Casual and outdoor clothes are also on sale. Opened by the Hebden Bridge-based Vocation Brewery, the beer hall has brews on tap, with a kitchen run by Slap and Pickle that serves burgers made with 40-day dry-aged Swaledale beef, plus vegan options. With its knockout medieval cathedral and genteel High Street with Regency bow-fronted shop windows, Winchester is an instant heart-stealer. The city’s historic nooks and crannies look ripe for a bodice-ripping period drama, so it’s little surprise that Jane Austen lived, wrote and was buried here in 1817. During advent, the entire city seems sprinkled with fairy dust, with lights and trees aglow. Right at the heart is , an 11th-century stunner in warm stone, with a magnificent Perpendicular Gothic nave and a vaulted Norman crypt that floods when it rains, hiding Anthony Gormley’s statue of a contemplative man, The cathedral gets its festive groove on with events from chamber choir concerts to lantern parades, carol workshops and one of the country’s loveliest Christmas markets. More history? Check out the iconic Round Table of Arthurian legend in the hammer-beamed, stained glass-lit medieval . Combine a shop with a bracing winter walk. The city snuggles up to the pretty chalk hills of the South Downs National Park. A soul-stirring 11-mile stomp leads to Beacon Hill, where far-reaching views of the Solent and the Isle of Wight on clear days. Kick off with a spin of the (until December 22) in the atmospheric cathedral close. Here log cabins do a brisk trade in mulled wine and crafts from hand-carved toys and decorations to wreaths, beeswax candles, pottery and alpaca woollies. Year-round the cathedral has a cracking second-hand book stall, . There’s a tight cluster of independent shops in the cobbled lanes of , between the cathedral and the college, among them (for antique maps and engravings), (for quality one-off gifts and toys) and of , where Jane Austen once shopped for tomes. If you’re after gourmet stocking fillers, check out on St George’s Street for artisanal cheese, charcuterie and wine, and on the High Street for divine Christmas truffles. All wonky beams, cosy corners and medieval vibes, the 600-year-old, Grade II-listed is the must-score table. It’s run by a group of passionate foodie friends and it shows in festive, farm-to-fork menus starring dishes like confit pork and black pudding croquettes with mustard, lovage and bitter leaves, and Hampshire venison with peppered squash, sprout flowers, blackberries, boulangère potatoes and thyme jus. Or for brunch, coffee and cake, cocktails and wintry lunch specials like beef bourguignon, stop by the foliage-draped on The Square. Want to stay the night? Of course you do. A whisper away from the cathedral, the has a dash of historic flair and luxe rooms and suites – some with rolltop baths for a post-shop bubble.COPENHAGEN, Denmark--(BUSINESS WIRE)--Dec 8, 2024-- Genmab A/S (Nasdaq: GMAB): Genmab A/S (Nasdaq: GMAB) today announced results from the Phase 1b/2 EPCORE ® CLL-1 clinical trial evaluating epcoritamab (Abstract #883), a T-cell engaging bispecific antibody administered subcutaneously, demonstrated an overall response rate (ORR) of 61 percent and a complete response (CR) rate of 39 percent in difficult-to-treat adult patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) treated with epcoritamab monotherapy. These results, from the monotherapy expansion (EXP) cohort (n=23) of the trial, along with the first safety data from the optimization (OPT) cohort, were presented at the 66 th Annual Meeting and Exposition of the American Society of Hematology (ASH), during the ASH Annual Meeting Press Program. The data will be presented during an oral session on December 9, 2024. In the EXP cohort, the median time to response was two (2.0) months and the median time to CR was 5.6 months. Among all patients in the cohort, median progression-free survival (PFS) was 12.8 months and median overall survival (OS) was not reached (median follow-up was 22.8 months). An estimated 65 percent of patients were alive at 15 months. Among 12 responders evaluable for minimal residual disease (MRD) by next-generation sequencing in peripheral blood, nine patients (75 percent) had undetectable MRD. The most frequent non-hematologic treatment-emergent adverse events (TEAEs) in the EXP cohort were cytokine release syndrome (CRS; 96 percent), diarrhea (48 percent), peripheral edema (48 percent), fatigue (43 percent), and injection-site reaction (43 percent). Cytopenias were common (anemia, 65 percent; thrombocytopenia, 65 percent; neutropenia, 48 percent); however, most patients had baseline anemia and thrombocytopenia, suggesting that these events were largely disease-related. Three cases of immune effector cell-associated neurotoxicity syndrome (ICANS) were reported (one Grade 1; two Grade 2), and there was one clinical tumor lysis syndrome (CTLS) case (Grade 2). These cases did not lead to treatment discontinuation. Four fatal TEAEs occurred - two cases of pneumonia, one case of sepsis and one case of squamous cell carcinoma of the skin. The EXP cohort followed a 2-step step-up dose regimen, and CRS was manageable and primarily low grade (9 percent Grade 1, 70 percent Grade 2, 17 percent Grade 3). In the first data from the separate OPT cohort, which followed a 3-step step-up dose regimen, CRS severity was substantially reduced with only low-grade events (71 percent Grade 1, 12 percent Grade 2). In both cohorts, CRS events primarily occurred following the first full dose, and none led to treatment discontinuation. No ICANS or CTLS cases were reported in the OPT cohort. “These EPCORE CLL-1 data are encouraging, especially as the majority of patients were heavily pre-treated with at least four lines of therapy,” said Alexey Danilov, MD, PhD, Marianne and Gerhard Pinkus, Professor and Director of Early Clinical Therapeutics and Associate Director of the Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope. “Despite progress in treating chronic lymphocytic leukemia, there remains a tremendous need for additional therapeutic options for high-risk patients whose disease has progressed following standard chemoimmunotherapy and targeted therapies.” Additional data from the EXP cohort showed high response rates in patients with high-risk factors treated with epcoritamab, including TP53 aberrations, IGHV-unmutated disease and double-exposed disease – prognostic markers that are associated with disease progression and decreased survival. i,ii,iii In patients with TP53 aberrations (n=15), the ORR was 67 percent with a CR of 33 percent. Among patients with IGHV-unmutated disease (n=16), the ORR was 63 percent, and the CR was 44 percent. In double-refractory patients, the ORR was 53 percent, and the CR was 37 percent. All patients in the trial had prior chemoimmunotherapy, and most patients had previously received targeted therapies such as BTK and BCL2 inhibitors (double-exposed) and had high-risk disease characteristics. “Chronic lymphocytic leukemia is incurable, and patients often need a variety of treatments throughout their lifetime, especially if their disease has high-risk prognostic factors, has relapsed or has become refractory to the current standard-of-care, including targeted therapies,” said Dr. Judith Klimovsky, Executive Vice President & Chief Development Officer, Genmab. “These early data show the potential therapeutic applicability of epcoritamab in relapsed or refractory chronic lymphocytic leukemia, and further reinforce the potential of epcoritamab as a core therapy for the treatment of B-cell malignancies.” Use of epcoritamab in CLL is not approved in the U.S. or in the EU or in any other territory. The safety and efficacy of epcoritamab for use in CLL have not been established. About Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia, affecting over 200,000 people in the United States alone. iv Chronic lymphocytic leukemia can be classified as either slow growing (indolent) or fast growing (aggressive). v CLL is incurable, and many patients will likely relapse and progress on frontline therapies. vi Most patients will experience consecutive episodes of disease progression and will require several lines of treatment in their lifetime. vii,viii About the EPCORE ® CLL-1 Trial EPCORE ® CLL-1 is a Phase 1b/2, open-label, multi-center trial to evaluate the safety and preliminary efficacy of epcoritamab as a monotherapy and in combination with standard of care agents in patients with difficult-to-treat relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), R/R small lymphocytic lymphoma (SLL) and Richter's Syndrome (RS). The trial consists of two parts: a dose-escalation phase (Phase 1b) and an expansion phase (Phase 2). Patients with RS are only included in the expansion phase. The primary objective of Phase 1b is to determine the recommended Phase 2 dose and the maximum tolerated dose as well as establish the safety profile of epcoritamab monotherapy and epcoritamab plus venetoclax in participants with R/R CLL. The purpose of Phase 2 is to assess and evaluate the preliminary efficacy, safety and tolerability profiles of epcoritamab monotherapy and epcoritamab plus venetoclax for patients with R/R CLL and SLL. Additionally, epcoritamab monotherapy and combination therapy will be evaluated in patients with RS to assess their efficacy, safety and tolerability profiles. More information on this trial can be found at https://www.clinicaltrials.gov/ (NCT: 04623541). About Epcoritamab Epcoritamab is an IgG1-bispecific antibody created using Genmab's proprietary DuoBody ® technology and administered subcutaneously. Genmab's DuoBody-CD3 technology is designed to direct cytotoxic T cells selectively to elicit an immune response toward target cell types. Epcoritamab is designed to simultaneously bind to CD3 on T cells and CD20 on B cells and induces T-cell-mediated killing of CD20+ cells. ix Epcoritamab (approved under the brand name EPKINLY ® in the U.S. and Japan, and TEPKINLY ® in the EU) has received regulatory approval in certain lymphoma indications in several territories. Epcoritamab is being co-developed by Genmab and AbbVie as part of the companies' oncology collaboration. The companies will share commercial responsibilities in the U.S. and Japan, with AbbVie responsible for further global commercialization. Both companies will pursue additional international regulatory approvals for the investigational R/R FL indication and additional approvals for the R/R DLBCL indication. Genmab and AbbVie continue to evaluate the use of epcoritamab as a monotherapy, and in combination, across lines of therapy in a range of hematologic malignancies. This includes five ongoing Phase 3, open-label, randomized trials including a trial evaluating epcoritamab as a monotherapy in patients with R/R DLBCL compared to investigator's choice chemotherapy ( NCT04628494 ), a trial evaluating epcoritamab in combination with R-CHOP in adult patients with newly diagnosed DLBCL ( NCT05578976 ), a trial evaluating epcoritamab in combination with rituximab and lenalidomide (R 2 ) in patients with R/R FL ( NCT05409066 ), a trial evaluating epcoritamab in combination with rituximab and lenalidomide (R 2 ) compared to chemoimmunotherapy in patients with previously untreated FL ( NCT06191744 ), and a trial evaluating epcoritamab in combination with lenalidomide compared to chemotherapy infusion in patients with R/R DLBCL ( NCT06508658 ). The safety and efficacy of epcoritamab has not been established for these investigational uses. Please visit www.clinicaltrials.gov for more information. EPKINLY ® (epcoritamab-bysp) U.S. INDICATIONS & IMPORTANT SAFETY INFORMATION What is EPKINLY? EPKINLY is a prescription medicine used to treat adults with certain types of diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, or follicular lymphoma (FL) that has come back or that did not respond to previous treatment after receiving 2 or more treatments. EPKINLY is approved based on patient response data. Studies are ongoing to confirm the clinical benefit of EPKINLY. It is not known if EPKINLY is safe and effective in children. Important Warnings—EPKINLY can cause serious side effects, including: People with DLBCL or high-grade B-cell lymphoma should be hospitalized for 24 hours after receiving their first full dose of EPKINLY on day 15 of cycle 1 due to the risk of CRS and neurologic problems. Tell your healthcare provider or get medical help right away if you develop a fever of 100.4°F (38°C) or higher; dizziness or lightheadedness; trouble breathing; chills; fast heartbeat; feeling anxious; headache; confusion; shaking (tremors); problems with balance and movement, such as trouble walking; trouble speaking or writing; confusion and disorientation; drowsiness, tiredness or lack of energy; muscle weakness; seizures; or memory loss. These may be symptoms of CRS or neurologic problems. If you have any symptoms that impair consciousness, do not drive or use heavy machinery or do other dangerous activities until your symptoms go away. EPKINLY can cause other serious side effects, including: Your healthcare provider will monitor you for symptoms of CRS, neurologic problems, infections, and low blood cell counts during treatment with EPKINLY. Your healthcare provider may temporarily stop or completely stop treatment with EPKINLY if you develop certain side effects. Before you receive EPKINLY, tell your healthcare provider about all your medical conditions, including if you have an infection, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. If you receive EPKINLY while pregnant, it may harm your unborn baby. If you are a female who can become pregnant, your healthcare provider should do a pregnancy test before you start treatment with EPKINLY and you should use effective birth control (contraception) during treatment and for 4 months after your last dose of EPKINLY. Tell your healthcare provider if you become pregnant or think that you may be pregnant during treatment with EPKINLY. Do not breastfeed during treatment with EPKINLY and for 4 months after your last dose of EPKINLY. In DLBCL or high-grade B-cell lymphoma, the most common side effects of EPKINLY include CRS, tiredness, muscle and bone pain, injection site reactions, fever, stomach-area (abdominal) pain, nausea, and diarrhea. The most common severe abnormal laboratory test results include decreased white blood cells, decreased red blood cells, and decreased platelets. In follicular lymphoma the most common side effects of EPKINLY include injection site reactions, CRS, COVID-19, tiredness, upper respiratory tract infections, muscle and bone pain, rash, diarrhea, fever, cough, and headache. The most common severe abnormal laboratory test results include decreased white blood cells and decreased red blood cells. These are not all of the possible side effects of EPKINLY. Call your doctor for medical advice about side effects. You are encouraged to report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch or to Genmab US, Inc. at 1-855-4GENMAB (1-855-443-6622). Please see Full Prescribing Information and Medication Guide , including Important Warnings. Globally, prescribing information varies; refer to the individual country product label for complete information. About Genmab Genmab is an international biotechnology company with a core purpose of guiding its unstoppable team to strive toward improving the lives of patients with innovative and differentiated antibody therapeutics. For 25 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with knock-your-socks-off (KYSO ® ) antibody medicines. Established in 1999, Genmab is headquartered in Copenhagen, Denmark, with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X . This Media Release contains forward looking statements. The words “believe,” “expect,” “anticipate,” “intend” and “plan” and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with preclinical and clinical development of products, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products or technologies obsolete, and other factors. For a further discussion of these risks, please refer to the risk management sections in Genmab’s most recent financial reports, which are available on www.genmab.com and the risk factors included in Genmab’s most recent Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC), which are available at www.sec.gov . Genmab does not undertake any obligation to update or revise forward looking statements in this Media Release nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law. Genmab A/S and/or its subsidiaries own the following trademarks: Genmab ®; the Y-shaped Genmab logo ®; Genmab in combination with the Y-shaped Genmab logo ®; HuMax ®; DuoBody ®; HexaBody ®; DuoHexaBody ®, HexElect ® and KYSOTM. EPCORE ®, EPKINLY ®, TEPKINLY ® and their designs are trademarks of AbbVie Biotechnology Ltd. i Campo, et al. TP53 Aberrations in Chronic Lymphocytic Leukemia: An Overview of the Clinical Implications of Improved Diagnostics. Haematologica . 2018 Nov 15;103(12):1956–1968. https://haematologica.org/article/view/8691 . ii Galieni, et al. Unmutated IGHV at Diagnosis in Patients With Early Stage CLL Independently Predicts for Shorter Follow-Up Time to First Treatment (TTFT). Leukemia Research. 2024. https://doi.org/10.1016/j.leukres.2024.107541 . iii Zuber, et al. Efficacy and Effectiveness Outcomes of Treatments for Double-Exposed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Patients: A Systematic Literature Review. Cancer Medicine . 2024. https://doi.org/10.1002/cam4.70258 . iv Fedele, et al. Chronic Lymphocytic Leukemia: Time to Care for the Survivors. Journal of Clinical Oncology . 2024. https://ascopubs.org/doi/10.1200/JCO.23.02738 . v Penn Medicine. Chronic Lymphocytic Leukemia (CLL). Accessed November 2024. https://www.pennmedicine.org/cancer/types-of-cancer/leukemia/types-of-leukemia/chronic-lymphocytic-leukemia . vi Odetola, et al. Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL). Curr Hematol Malig Rep . 2023 Jun 6:1–14. doi: 10.1007/s11899-023-00700-z vii Moreno, Carol. Standard Treatment Approaches for Relapsed/Refractory Chronic Lymphocytic Leukemia After Frontline Chemoimmunotherapy. Hematology Am Soc Hematol Educ Program . 2020 Dec 4;2020(1):33-40. doi: 10.1182/hematology.2020000086. viii Leukemia & Lymphoma Society. Relapsed and Refractory CLL. Accessed November 2024. https://www.lls.org/leukemia/chronic-lymphocytic-leukemia/treatment/relapsed-and-refractory . ix Engelberts PJ, et al. DuoBody-CD3xCD20 Induces Potent T-Cell-Mediated Killing of Malignant B Cells in Preclinical Models and Provides Opportunities for Subcutaneous Dosing. EBioMedicine . 2020;52:102625. doi: 10.1016/j.ebiom.2019.102625. View source version on businesswire.com : https://www.businesswire.com/news/home/20241208951291/en/ CONTACT: David Freundel, Senior Director, Global R&D & Portfolio Communications T: +1 609 430 2481; E:dafr@genmab.com Andrew Carlsen, Vice President, Head of Investor Relations T: +45 3377 9558; E:acn@genmab.com KEYWORD: DENMARK EUROPE INDUSTRY KEYWORD: RESEARCH FDA CLINICAL TRIALS BIOTECHNOLOGY HEALTH PHARMACEUTICAL OTHER SCIENCE SCIENCE ONCOLOGY SOURCE: Genmab A/S Copyright Business Wire 2024. PUB: 12/08/2024 11:00 AM/DISC: 12/08/2024 11:02 AM http://www.businesswire.com/news/home/20241208951291/enMeta to build $10 billion AI data center in Louisiana as Elon Musk expands his Tennessee AI facility
Huda Beauty’s Black Friday sale is well underway, and with up to 80 per cent off, now is the perfect time to get some Christmas shopping sorted. There are super savings to be had across some of the brand’s bestselling hero products. With deals on bundles, their iconic eyeshadow palettes and that powder that you’ve likely seen all over TikTok. When shopping the Black Friday sales, there’s certainly no right or wrong way to do things – whether you’re armed with a list weeks before or go in blind to make exciting in-the-moment decisions. But, trying to make sense of what truly is a great buy can be difficult. As a beauty expert, I’ve worked my way through Huda Beauty’s Black Friday sale to handpick the buys that I wouldn’t miss. From the cult #fauxfilter concealer to vanilla royale sugared patchouli perfume , there are so many goodies in the sale. Better still, you’ll get free gifts when spending over a certain threshold. A much-loved brand among make-up fanatics, and with a huge following, it’s easy to see why Huda Beauty’s sales gather a lot of attention. The brand is well known for its offering of make-up with rich pigments and incredible formulas, along with false lashes, skincare and perfume. There are some great bargains to be had at Huda Beauty, so I’ve unpacked everything you need to know about their Black Friday sale, and how to get those exciting free gifts. Read more: Follow live – Black Friday deals and shopping tips The colour-correcting version of the famous Huda Beauty #fauxfilter concealer has been designed to correct, even out and brighten the undereye area, with a formulation that is creamy and comfortable. Making sure that transfer is minimal, and your eye area stays picture-perfect throughout the day, the non-comedogenic formulation is sweat- and crease-proof. Now, you can get 25 per cent off thanks to Huda Beauty’s Black Friday sale. Many of the shades are selling out fast, which is no surprise as it is one of Huda Beauty’s bestselling products. But, if you’re lucky enough to get one of the liquid matte ultra-comfort transfer-proof lipsticks in the Black Friday sale, I’d edge towards the classic red shade – ‘slaytina’. Perfect for the holiday season, the liquid lipstick is suitable for eight-hour wear, making it the ideal choice for a Christmas party. The Huda Beauty easy bake loose powder secured the top place in The Independent ’s review of the best setting powders , thanks to its air-brushed finish and long-lasting formulation. This Black Friday, you can get a set of five minis for just £57. With 40 per cent off, you’ll get a set containing some of the bestselling shades – banana bread, blondie, kunafa, pound cake, and cherry blossom cake. Make sure your eyelids are sparkling as we enter 2025 with this eyeshadow palette from Huda Beauty. A reimagination of the brand's bestselling new nude palette, it contains 18 magical shades in five different textures so that you can wear it from day to night. In the bottom left, the shade ‘slippery’ is there to highlight and brighten, with a very rich, bright pink pigment. While I will occasionally dabble in brighter shades, ‘flower power’, ‘tantric’ and ‘please me’ would be the first colours to get down to the pan for me. For a natural flush across the cheeks, Huda Beauty's cheeky tint blush stick glides on beautifully, allowing for a personalised level of intensity. There are four shades to choose from, and I’d go for ‘proud pink’, for a dewy and healthy complexion (even when the winter weather has sucked all the colour out). Every false eyelash lover needs a great lash glue, and the sticky tack latex-free lash glue is now half-price. The formulation is waterproof and fast drying, leaving behind a barely-there clear trace that lasts all day long. The precise brush is particularly handy for getting back in those corners if the edges start to lift. With the Huda Beauty Black Friday sale already underway, now is the time to shop. Many of the bestselling products are flying out of stock, so I wouldn’t hang around if you need to tick off your Christmas shopping or stock up on your favourites. Bundles are one of the best ways to shop the sale, as the already discounted prices have been hit with a further reduction. You can choose from products that sit in various discount categories, from up to 30 per cent off, right up to 80 per cent off. It's also worth noting, that if you spend £115, you'll get two free gifts. For a £155 spend it's three free gifts, and four when spending £190. Find out everything you need to know about Black Friday 2024, with our expert guide
Biden calls for Assad to be 'held accountable'
CORAL GABLES, Fla. (AP) — Miami probably was one win away from getting into the College Football Playoff. Iowa State definitely was one win away. Their consolation prize of sorts: playing one another. The Hurricanes and Cyclones — a meteorological matchup — have accepted bids to the Pop-Tarts Bowl, to be played Dec. 28 in Orlando, Florida. Iowa State (10-3) is looking for its first 11-win season in the program's 133-year history, and Miami (10-2) is seeking its first 11-win season since 2003. Miami's loss at Syracuse to close the regular season wound up being the game the Hurricanes could point to as the reason they missed out on the CFP. Iowa State could have played its way in and lost the Big 12 title game to CFP-bound Arizona State on Saturday. “I think everyone that doesn't get in feels disappointment,” Miami coach Mario Cristobal said. “We feel the onus of just doing better. Just do better, go forward, have an opportunity to get better.” It's essentially the same task for both teams: regrouping after seeing the playoff slip away. “I think that’s what’s made Iowa State football really special is our ability to have great resiliency," Cyclones coach Matt Campbell said. "And I know our kids are super-excited about the opportunity to finish off. Obviously (Saturday) was disappointing. But this group and this football team has the opportunity to just continue to fight.” A big question for Miami: whether quarterback Cam Ward will play. The likely Heisman Trophy finalist has thrown for 155 touchdown passes in his career at Incarnate Word, Washington State and Miami. That’s tied for the most by anyone in Division I (FBS and FCS) history; Case Keenum threw 155 in his career at Houston. Many draft-bound players not in the playoff will be opting out of bowl games over the coming weeks. There's been no indication from Miami yet that Ward or any other draft-bound player has made a decision. “I think it’s important that our guys, anyone playing and closing out the season, understands the importance of that next step for a program like ours," Cristobal said. "And I think our guys do.” Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.
WEST PALM BEACH, Fla. (AP) — President-elect Donald Trump said Saturday that he wants real estate developer Charles Kushner , father of Trump’s son-in-law Jared Kushner, to serve as ambassador to France. Trump made the announcement in a Truth Social post, calling Charles Kushner “a tremendous business leader, philanthropist, & dealmaker." Javascript is required for you to be able to read premium content. Please enable it in your browser settings.The DailyWire+ satirical documentary Am I Racist? broke records by making more than $12 million at the box office. It also landed a session in Deadline’s awards-season showcase Contenders Documentary . In the movie, director Justin Folk films Matt Walsh infiltrating leaders in diversity movements and causing a scene in disguise. Walsh interrupted a Saira Rao dinner lecture decrying white women by dropping stacks of plates. While Walsh and Folk disagree with the sentiments expressed by activists like Rao, they also spoke with regular Americans in Black and white communities. Walsh said the message is that Americans want to move on from discussing race. “I think for a lot of people, they feel like, ‘Let’s move on. Let’s not dwell on these things,’” Walsh said. “By the way, that was the message we heard in the film, not just from white people. We went down south to Louisiana — a Black community in Louisiana, New Orleans — and we heard the same thing. They said, ‘Look, I’m not focused on this racism thing. Let’s just live our lives.’” Folk agreed that people want to move on, adding that many they spoke with entertained discussions of race out of politeness. “I think people in general, whether it be white men or white women or anybody in between, even minorities, they’re polite,” Folk said. “They don’t want to be called haters. They don’t want to be called bigots. They don’t want to be called racist, and I think they’ve taken advantage of that and pushed an agenda and overstepped with that.” Asked whether they acknowledged that there has been structural racism in the past, they concurred there has been. Walsh said credit is also due for correcting those systems. RELATED: Contenders Documentary — Deadline’s Complete Coverage “We are a country that had slavery at one point,” Walsh said. “That’s a pretty good example. Now, although slavery existed as an institution all across the world for thousands of years, in this country it certainly was a racist institution. Nobody denies that. But, in modern America as it stands today, there are no laws or policies on the books that have the intention of disadvantaging Black people, people that we call, quote unquote, people of color. That doesn’t exist today, and I think you have to allow society to progress.” Walsh also pushed back on the notion that the legacies of racist policies, such as Black soldiers being excluded from the GI Bill, still have impacts on minorities. He suggested that one wouldn’t have to go back far to find oppression in anyone’s lineage. RELATED: The 2025 Oscars: Everything We Know So Far About The Nominations, Ceremony, Date & Host “If my Irish ancestors, for example, were not horrifically discriminated against in the early part of the 20th century, where would my life be today?” Walsh said. “At a certain point you have to decide either we are going to stay dwelling on the past and trying to cash in on things that didn’t even happen to us but happened to people 100 years ago. Or we’re going to just move on and say, ‘Now is today. It’s the present moment, and we now live in a situation in a country where we can take charge of our own lives.’” Folk agreed with the goal to move forward “and not repeat the same mistakes of the past, which were mistakes made because of race.” Check back Monday for the panel video.MADRID (AP) — Kylian Mbappé admitted he is going through a difficult moment as he missed another penalty kick and Real Madrid lost ground to Barcelona in the Spanish league after a 2-1 loss at Athletic Bilbao on Wednesday. Mbappé had his penalty saved by Athletic goalkeeper Julen Agirrezabala in the 68th minute, and later Federico Valverde gifted a late goal by losing possession on defense to allow an easy winner by Gorka Guruzeta in the 80th. “Bad result,” Mbappé posted on Instagram. “A big mistake in a match where every detail counts. I take full responsibility for it. A difficult moment but it's the best time to change this situation and show who I am.” Mbappé sent the penalty shot to his right and Agirrezabala dived that way to make the stop. “We knew that he is a good penalty taker,” Agirrezabala said. “He missed the last one and I believed that he was going to choose the same side and luckily that’s what happened.” Mbappé, who had a goal disallowed for offside in the 13th, had also missed a penalty in Madrid’s 2-0 loss at Liverpool in the Champions League last week. He didn’t take the one for the club in a Spanish league match on Sunday, but he scored in the 2-0 win over Getafe to ease some of the pressure on him and the club. But it was another lackluster outing for the France star, who continues to struggle in his first season since finally joining the Spanish powerhouse. “I won’t evaluate the performance of a player because of a missed penalty. Obviously he is sad and disappointed, but you have to move on,” Madrid coach Carlo Ancelotti said about Mbappé. “He is not at his best level, but you have to give him time to adapt. You have to give him time to be able to do better.” Ancelotti also downplayed the bad play by Valverde, saying that mistakes can happen to anyone. Valverde had control of the ball but gave it away while trying to get past a couple of Athletic players instead of passing it to a teammate, leaving Guruzeta with an easy run into the area for his goal. Álex Berenguer had put the hosts ahead in the 53td and Jude Bellingham equalized for Madrid in the 78th. The defeat left Madrid four points behind Barcelona, which on Tuesday ended a three-match winless streak in the league with a 5-1 rout at Mallorca. Madrid, which has a game in hand, had won three consecutive league games since a 4-0 loss at home in the “clasico” against Barcelona. Madrid has lost five of its last 11 matches in all competitions. Athletic moved to fourth place with the victory, its fourth consecutive across all competitions. Both matches on Tuesday and Wednesday were moved forward in the schedule because the clubs will be playing in the Spanish Super Cup in January. Copa del Rey In the Copa del Rey, first-division clubs Rayo Vallecano, Valencia and Real Betis all advanced over lower-division teams in the second round, but Villarreal lost 1-0 to fourth-division club Pontevedra and Girona fell on penalties to fourth-tier team Logrones. ___ AP soccer: https://apnews.com/hub/soccer Tales Azzoni, The Associated Press
Fashion event celebrates 75 years of Indonesia, PH diplomatic ties
Jenkins throws for 3 TDs to carry FIU to 35-24 win over Middle Tennessee