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On Wednesday, December 4, at 2:00pm ET , at the Center for Strategic and International Studies, National Security Advisor Jake Sullivan will deliver an address on sharpening America’s war-fighting edge and fortifying the U.S. defense industrial base—one of the most important aspects of America’s security and prosperity—for an era of strategic competition. Informed by the experiences of Russia’s full-scale invasion of Ukraine, the rapid advance of new technology, and the changing character of the strategic landscape, Mr. Sullivan will share steps the Biden administration has taken to rebuild the U.S. defense industrial base after decades of under-investment and the work that remains—at home and with allies—at this high-stakes moment. Mr. Sullivan will join Seth Jones, president of the CSIS Defense and Security Department, for a fireside chat following his keynote address. Jake Sullivan is the 28th Assistant to the President for National Security Affairs (National Security Advisor). In the Obama-Biden Administration, he served as Deputy Assistant to the President and National Security Advisor to then-Vice President Biden, Director of the Policy Planning Staff at the U.S. Department of State, and Deputy Chief of Staff to Secretary of State Hillary Clinton. This event is made possible through general support to CSIS.In a groundbreaking effort to enhance medical treatments for hearing loss and other inner ear conditions, a dedicated team of physicians and engineers has collaborated for over a decade to develop an innovative microneedle. This ultrathin and ultrasharp device is poised to change the precision medicine landscape for the inner ear. The creators of this cutting-edge needle, ENT surgeon Anil Lalwani and mechanical engineer Jeffrey Kysar from Columbia University, believe their invention will be a game-changer in delivering therapies to previously inaccessible areas within the cochlea—the spiral-shaped, fluid-filled structure in the inner ear responsible for hearing. “It’s not an exaggeration to say our microneedle could be key to precision medicine for the inner ear,” Lalwani remarked. The need for microneedle The development of this microneedle comes at a critical time when gene therapy can potentially restore hearing by regenerating cells damaged by loud noises. However, accurately and safely delivering these therapies has proven challenging due to the cochlea’s complex anatomy. Accessing the necessary cells requires navigating through a roughly 2 mm wide delicate membrane that often tears when traditional surgical instruments are used. This tearing can lead to irreversible hearing loss and balance issues. One of the primary objectives of this microneedle is to introduce treatments into the cochlea without damaging this fragile membrane. Additionally, the needle will enable fluid extraction from the cochlea, aiding in diagnosing inner ear disorders like Meniere’s disease, which causes dizziness, nausea, and hearing loss. Analyzing this fluid could enhance understanding of these conditions and facilitate the development of more effective treatments. A unique collaboration The partnership between Lalwani and Kysar began unexpectedly about twelve years ago when two mutual postdoctoral researchers saw the potential for collaboration. Initially, Kysar was surprised to learn about the challenges of accessing the inner ear. “I had imagined that doctors could access any place in the human body,” he admitted. However, the inner ear remained largely unexplored, presenting a unique opportunity for engineering innovation. Intrigued by the engineering challenges involved, Kysar dove into research, discovering scant literature addressing the intricacies of the cochlea’s membrane. This lack of existing knowledge further fueled his interest in developing a solution. Microneedle challenges and solutions Kysar explained that one of the core challenges in creating the needle lay in understanding the factors that cause materials to tear. The team conceptualized the cochlear membrane as a tightly stretched tarp—if a hole is too large, it will rip, but if it’s small enough, it can remain stable. The goal was to create a microneedle thinner than the critical size of the membrane, comparable to the width of a human hair. To achieve this, Kysar and Lalwani utilized advanced manufacturing techniques like two-photon photolithography, a 3D printing method capable of producing extremely fine-resolution structures. This technology allows them to create sharper needles than existing medical needles and is strong enough to withstand practical use. Through extensive testing, the team ensured that their microneedles could perform flawlessly. They conducted numerous animal surgeries without observing any negative effects or hearing loss. The microneedle creates a puncture no larger than its diameter, and the membrane heals within about two days. Looking ahead As they continue refining their design, Lalwani and Kysar are optimistic about the potential of their microneedle. They envision it transforming the treatment of inner ear conditions and paving the way for new therapeutic approaches in audiology. With ongoing advancements in medical technology and a focus on precise interventions, the future of hearing restoration and inner ear health looks promising.skygaming777 。

Ross Doohan determined to be Aberdeen’s No.1 – even after Dimitar Mitov returns from injuryWEST PALM BEACH, Fla. (AP) — President-elect Donald Trump said Wednesday that he has chosen Keith Kellogg, a highly decorated retired three-star general, to serve as his special envoy for Ukraine and Russia. Kellogg, who is one of the architects of a staunchly conservative policy book that lays out an “America First” national security agenda for the incoming administration, will come into the role as Russia’s invasion of Ukraine enters its third year in February. Trump, making the announcement on his Truth Social account, said, “He was with me right from the beginning! Together, we will secure PEACE THROUGH STRENGTH, and Make America, and the World, SAFE AGAIN!” Kellogg, an 80-year-old retired Army lieutenant general who has long been Trump’s top adviser on defense issues, served as national security adviser to Vice President Mike Pence , was chief of staff of the National Security Council and then stepped in as an acting security adviser for Trump after Michael Flynn resigned. As special envoy for Ukraine and Russia, Kellogg will have to navigate an increasingly untenable war between the two nations. The Biden administration has begun urging Ukraine to quickly increase the size of its military by drafting more troops and revamping its mobilization laws to allow for the conscription of those as young as 18. The White House has pushed more than $56 billion in security assistance to Ukraine since the start of Russia’s February 2022 invasion and expects to send billions more before Biden leaves office in less than two months. The U.S. has recently stepped up weapons shipments and has forgiven billions in loans provided to Kyiv. Trump has criticized the billions the Biden administration has spent in supporting Ukraine and has said he could end the war in 24 hours, comments that appear to suggest he would press Ukraine to surrender territory that Russia now occupies. As a co-chairman of the American First Policy Institute’s Center for American Security, Kellogg wrote several of the chapters in the group’s policy book. The book, like the Heritage Foundation’s “Project 2025,” is designed to lay out a Trump national security agenda and avoid the mistakes of 2016 when he entered the White House largely unprepared. Kellogg in April wrote that “bringing the Russia-Ukraine war to a close will require strong, America First leadership to deliver a peace deal and immediately end the hostilities between the two warring parties.” Trump's proposed national security adviser , U.S. Rep. Michael Waltz of Florida, tweeted Wednesday that “Keith has dedicated his life to defending our great country and is committed to bringing the war in Ukraine to a peaceful resolution.” Kellogg featured in multiple Trump investigations dating to his first term. He was among the administration officials who listened in on the July 2019 call between Trump and Volodymyr Zelenskyy in which Trump prodded his Ukrainian counterpart to pursue investigations into the Bidens. The call, which Kellogg would later say did not raise any concerns on his end, was at the center of the first of two House impeachment cases against Trump, who was acquitted by the Senate both times. On Jan. 6, 2021, hours before pro-Trump rioters stormed the U.S. Capitol, Kellogg, who was then Pence’s national security adviser, listened in on a heated call in which Trump told his vice president to object or delay the certification in Congress of President Joe Biden ’s victory. He later told House investigators that he recalled Trump saying to Pence words to the effect of: “You’re not tough enough to make the call.” Baldor reported from Washington. AP writer Eric Tucker in Washington contributed to this report.

Boeing has paused its efforts to install and use employee-monitoring sensors, including at its office in Everett, Washington, after media inquiries followed an employee's leak of the plans. An unnamed Boeing employee at Everett, a key manufacturing site for the aerospace giant's jumbojets, shared an internal PowerPoint presentation with The Seattle Times touting the benefits of the tracking technology. The plan reportedly called for installation of "workplace occupancy sensors" throughout Boeing's office that include motion sensors and cameras mounted in ceiling tiles, intended to monitor building occupancy. "As we shared with some employees last month, we were starting a pilot program using a system for managing energy and space usage in selected office areas," spokespeople for Boeing confirmed to The Register . "The system, used by other companies, analyzes motion data and environmental conditions and does not identify people or documents." "We have paused our pilot program at all locations and will keep employees updated," the aerospace goliath acknowledged. According to the leaked presentation, the system was at least deployed at Boeing's St Louis, Missouri offices in October, and work began on it in Everett on Monday. The planemaker declined to clarify exactly where and how the occupancy tracking technology had been rolled out before the pause. According to the newspaper's reading of the PowerPoint slides, the surveillance system, made by Avuity, is designed to gather information on office occupancy and usage of various spaces. The presentation tries to assuage employee fears about the workplace monitoring by noting the cameras used by the system only take blurry photos that don't identify individuals or the writing on documents, though that may not be sufficient to satisfy concerns. As we reported recently, workplace surveillance is quickly becoming the norm in offices around the world as businesses continue to push remote workers to return to the office - Boeing among them. There's a certain degree of reasonability to the presence of those systems, especially as post-pandemic work shifts have in many cases led to companies deciding to shrink their real-estate footprints. Boeing itself sold off a considerable amount of warehouse and office space in Everett in the wake of the pandemic, and may be looking to justify more offloading of space. That said, installing systems to visually track employees, with or without blurring, may not be the best approach, and Boeing's immediate course reversal on being questioned about the practice makes it seem like the jet builder knows that. "Employees should not accept any kind of indoor location tracking as long as there are no reliable safeguards that prevent employers from misusing the data for problematic purposes," Wolfie Christl, author of a report published last month about workplace surveillance, told The Register for an earlier story. "In Germany and Austria, an employer would need to negotiate the introduction of such a system with employees, who would have a right to audit how the employer uses the data." When it comes to worker's rights, the US and EU aren't exactly on the same page, though, which Christl said needs to change. "The US urgently needs appropriate laws that protect employees from disproportionate surveillance in the workplace," Christl said. Failing that, we'll just have to rely on more employees speaking up, which isn't necessarily a reliable strategy: the 737 Max manufacturer told its employees what it was doing, but not every company is likely to be as forthright, especially after this latest Boeing blowup. ®None

San Francisco quarterback Brock Purdy took part in some light throwing after missing his first career game due to an injury , and the 49ers are hoping he can return this week. Purdy hurt his throwing shoulder during a loss to Seattle on Nov. 17. Purdy underwent two MRIs last week that showed no structural damage. But Purdy he felt discomfort after making a few throws at practice on Thursday and was shut down for the game at Green Bay on Sunday that San Francisco lost 38-10 . Coach Kyle Shanahan said Monday that Purdy made it through the session without pain and will rest on Tuesday and hopefully be able to return to practice on Wednesday as the Niners prepare to play at Buffalo this coming week. "We rested it throughout the weekend hoping that would help," Shanahan said. "He threw lighter today to see if that rest helps and the rest did help him. So we'll see again, going through the same things we did last week. We're going to let him rest all the way up to Wednesday. We'll see how it feels on Wednesday and then we'll take the exact same course throughout the week. Hopefully it responds better this week than it did last week with the rest." Brandon Allen went 17 for 29 for 199 yards with a touchdown, an interception and a lost fumble in his first start since the 2021 season. Allen would play once again if Purdy is unable to go on Sunday at Buffalo. Purdy wasn't the only star player missing for the 49ers on Sunday with defensive end Nick Bosa missing the game with injuries to his left hip and oblique and left tackle Trent Williams out with an ankle injury. "Just waiting to see how they respond," Shanahan said. "They didn't respond great last week. That's why they weren't able to go. Nick and Trent are both in the same boat. ... We'll evaluate as this week progresses and hopefully it turns a better corner than it did last week." In other injury news, linebacker Dre Greenlaw will return to practice this week for the first time since tearing his Achilles tendon in the Super Bowl last season. Greenlaw will likely need at least a couple of weeks of practice before being able to return to play. Offensive lineman Jon Feliciano will be shut down for the rest of the season after his knee injury didn't fully heal. Feliciano's three-week practice window ended Monday and the Niners decided to keep him on injured reserve instead of activating him. Left guard Aaron Banks, defensive tackle Jordan Elliott and receiver Jacob Cowing all remain in concussion protocol to start this week and their status is unknown. Right guard Dominick Puni (shoulder) and cornerback Deommodore Lenoir (knee) underwent MRIs on Monday and the team is waiting for results. Cornerback Renardo Green (neck) and linebacker Demetrius Flannigan-Fowles (knee) are day to day. Defensive tackle Kevin Givens is expected to return to practice this week after missing the past four games with a groin injury.Nearly, hundreds of US Humvees were actually just left behind in the nation of Afghanistan , which are now rusting in scrapyards, approximately three years after the US withdrawal in the month of August in the year 2021, reported The Independent. ET Year-end Special Reads It's all Gucci for Indians' luxury craving even as economy shows wrinkles Investing in 2025: Will domestic funds continue to counter FPI sell-offs amid rising valuations? 2024 exposed the underbelly of India's Silicon Valley According to The Independent, numerous satellite images reveal these vehicles which are emblematic of the US military campaign are being actually dismantled and totally neglected at former NATO bases across various Afghan provinces. In spite of the efforts to destroy or dismantle military equipment during the chaotic pullout, significant amounts fell into Taliban hands as the US trained Afghan military totally collapsed. The Pentagon estimates that over $7.2 billion worth of military equipment was eventually abandoned with glimpses of this hardware appearing at several Taliban events, asserted The Independent. The Humvees were initially used for patrols by the Taliban but have now become increasingly impractical due to high fuel costs and a lack of spare parts, which are difficult to obtain outside US and European markets. Thus, as a result, the Taliban has resorted to using motorcycles for patrols and is cannibalizing the Humvees for parts. Eminent experts expressed their concern that the Taliban might eventually sell these vehicles on the black market specifically to neighboring countries like Pakistan and Iran, noted The Independent. 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Hundreds of US Humvees were actually just left behind in the nation of Afghanistan, which are now rusting in scrapyards, approximately three years after the US withdrawal in the month of August in the year 2021. How much worth of military equipment were abandoned in the Afghanistan? The Pentagon estimates that over $7.2 billion worth of military equipment was eventually abandoned with glimpses of this hardware appearing at several Taliban events. (You can now subscribe to our Economic Times WhatsApp channel )

Trump’s Cabinet And Key Jobs: Scott Bessent Expected As Treasury Secretary PickBiden opens final White House holiday season with turkey pardons and first lady gets Christmas tree

Trump selects longtime adviser Keith Kellogg as special envoy for Ukraine and RussiaWASHINGTON (AP) — President-elect Donald Trump's incoming administration is set to be less diverse than President Joe Biden's administration, but several people of color and women appear likely to serve in top roles. While Trump vigorously campaigned against diversity and inclusion efforts in business and government, his Cabinet selections and other high-profile staffing choices include some barrier-breaking nominations. The Cabinet, if confirmed, is set to be one-third women and include some historic firsts. Florida Sen. Marco Rubio, Trump’s pick to lead the State Department, would be the first Latino secretary of state. Scott Bessent, an American hedge fund manager and Trump’s pick to lead the Treasury Department, would be the first openly gay man in that post. Susie Wiles, Trump’s choice for White House chief of staff, will also be the first woman to serve in the position. Scott Turner, a former NFL player who led the White House Opportunity and Revitalization Council in the first Trump term, will serve as secretary of housing and urban development. Turner, who is Black, will be the fourth confirmed HUD secretary of color since 2014. Neurosurgeon Ben Carson, who is also Black, served in that post under Trump. Trump's first administration also included some historic firsts, including Veteran spy Gina Haspel serving as the first female director of the CIA, but, overall, it still lagged behind his predecessors on diversity. The incoming administration is set to include some people of color in other high-profile roles. Vivek Ramaswamy, a former biotechnology executive and 2024 GOP presidential candidate, will co-lead an outside advisory committee on government efficiency with billionaire Elon Musk. Tulsi Gabbard, a former Democratic congresswoman, is Trump's pick to serve as director of national intelligence, the chief coordinator of the nation's intelligence departments. Gabbard is of Samoan descent and Ramaswamy is Indian American. Mehmet Oz, a former TV doctor who unsuccessfully ran for Senate in Pennsylvania, has been tapped by Trump to lead the Centers for Medicare and Medicaid Services. And Janette Nesheiwat, a physician and Fox News personality, is Trump's pick to serve as surgeon general. Nesheiwat is the daughter of Christian Jordanian immigrants; Oz is Turkish American and would be the first Muslim to serve in the role. Trump’s Cabinet also includes a wide breadth of ideological diversity with some nominees holding views broadly considered eccentric in Washington. Others have clashing opinions on priorities for the incoming administration like trade and foreign policy. The Associated Press receives support from several private foundations to enhance its explanatory coverage of elections and democracy. See more about AP’s democracy initiative here . The AP is solely responsible for all content.What diversity does — and doesn't — look like in Trump's Cabinet