jiliko 747 live

France’s Michel Barnier faced an abrupt end to his premiership on Monday after key opposition parties said they would back a no-confidence motion against his government after only three months in power. Certain that the National Assembly would deny him a majority backing the government’s social security financing plan for next year, Barnier forced through the bill without a vote, using executive powers under article 49.3 of the French constitution. The conservative premier, who formed a minority government in September after an inconclusive general election, has lived under the constant threat of a no-confidence vote that could force him to quit. The government could be toppled as early as tomorrow, when a vote is expected. “I honestly believe that the French people will not forgive us if we prefer partisan interests to the best interest of the nation,” Barnier told the lawmakers. “This is a moment of truth in which everybody must take their responsibilities. I am taking mine,” he added. Far-left opposition party LFI said immediately it would bring a no-confidence motion which the far-right National Rally (RN) — the largest single party in France’s parliament — said it would vote in favour of, after accusing Barnier of failing to negotiate on some of the bill’s provisions. “We will vote no confidence,” the RN said on X. Key to any such vote is Marine Le Pen, the parliamentary leader of the RN that has opposed several parts of the government’s 2025 budget plan, including the social security financing bill submitted to the National Assembly on Monday. In a last-ditch concession to the RN, the prime minister’s office said it was scrapping plans for a less generous prescription drug reimbursement policy from next year. It was uncertain to the last moment whether the nod to Le Pen’s concerns would be enough to save the day for Barnier, who has little hope of finding any left-wing support. But in the end the “miracle” — which RN party leader Jordan Bardella said was needed to avoid the no-confidence motion — failed to materialise. LFI deputy Mathilde Panot said Barnier had sought to avoid the no-confidence vote by making “dishonourable” concessions to the RN. “On Wednesday he will get both, dishonour and the no-confidence vote,” she said, adding that the move would allow France to emerge from “a political impasse” and “political chaos”. If the government falls, it would be the first successful no-confidence vote since a defeat for Georges Pompidou’s government in 1962, when Charles de Gaulle was president. The life span of Barnier’s government would also be the shortest of any administration of France’s Fifth Republic since 1958. Le Pen had already reacted icily Sunday after Budget Minister Laurent Saint-Martin said the government did not plan any further changes to the social security budget plan. “We have taken note,” she told AFP, calling the stance “extremely closed-minded and partisan behaviour”. The RN is the largest single party in the 577-seat National Assembly, with more than 140 deputies. On Thursday, Barnier scrapped a previously planned increase on an electricity tax, in a concession to critics. Saint-Martin has highlighted that the budget proposals have already been discussed by a parliamentary commission ahead of Monday’s debate and changed following talks between National Assembly deputies and upper house senators. “To reject this text is to reject a democratic agreement,” he said. The Senate, where right-wing parties have a majority, partly approved the 2025 budget Sunday, giving a green light to government revenue projections, in a vote boycotted by the left. The Socialist party, part of the left-wing opposition, told Barnier it would vote against him if he used article 49.3 to push through a budget. Saint-Martin warned that the fall of the government would raise the risk premium on French government debt that has reached rare heights because of the country’s shaky financial situation.jiliko 747 live 。

Pressley: Biden 'must act' on clemency before leaving office

ENGLEWOOD, Colo. — John Elway says any remorse over bypassing Josh Allen in the 2018 NFL draft is quickly dissipating with rookie Bo Nix's rapid rise, suggesting the Denver Broncos have finally found their next franchise quarterback. Elway said Nix, the sixth passer selected in April's draft, is an ideal fit in Denver with coach Sean Payton navigating his transition to the pros and Vance Joseph's defense serving as a pressure release valve for the former Oregon QB. "We've seen the progression of Bo in continuing to get better and better each week and Sean giving him more each week and trusting him more and more to where last week we saw his best game of the year," Elway said in a nod to Nix's first game with 300 yards and four touchdown throws in a rout of Atlanta. For that performance, Nix earned his second straight NFL Rookie of the Week honor along with the AFC Offensive Player of the Week award. "I think the sky's the limit," Elway said, "and that's just going to continue to get better and better." In a wide-ranging interview with The Associated Press, Elway also touted former coach Mike Shanahan's Hall of Fame credentials, spoke about the future of University of Colorado star and Heisman favorite Travis Hunter and discussed his ongoing bout with a chronic hand condition. Elway spent the last half of his decade as the Broncos' GM in a futile search for a worthy successor to Peyton Manning, a pursuit that continued as he transitioned into a two-year consultant role that ended after the 2022 season. "You have all these young quarterbacks and you look at the ones that make it and the ones that don't and it's so important to have the right system and a coach that really knows how to tutelage quarterbacks, and Sean's really good at that," Elway said. "I think the combination of Bo's maturity, having started 61 games in college, his athletic ability and his knowledge of the game has been such a tremendous help for him,'" Elway added. "But also Vance Joseph's done a heck of a job on the defensive side to where all that pressure's not being put on Bo and the offense to score all the time." Payton and his staff have methodically expanded Nix's repertoire and incorporated his speed into their blueprints. Elway lauded them for "what they're doing offensively and how they're breaking Bo into the NFL because it's a huge jump and I think patience is something that goes a long way in the NFL when it comes down to quarterbacks." Elway said he hopes to sit down with Nix at some point when things slow down for the rookie. Nix, whose six wins are one more than Elway had as a rookie, said he looks forward to meeting the man who won two Super Bowls during his Hall of Fame playing career and another from the front office. "He's a legend not only here for this organization, but for the entire NFL," Nix said, adding, "most guys, they would love to have a chat with John Elway, just pick his brain. It's just awesome that I'm even in that situation." Orange Crush linebacker Randy Gradishar joined Elway in the Pro Football Hall of Fame this year, something Elway called "way, way overdue." Elway suggested it's also long past time for the Hall to honor Shanahan, who won back-to-back Super Bowls in Denver with Elway at QB and whose footprint you see every weekend in the NFL because of his expansive coaching tree. Elway called University of Colorado stars Travis Hunter and Shedeur Sanders "both great athletes." He said he really hopes Sanders gets drafted by a team that will bring him along like the Broncos have done with Nix, and he sees Hunter being able to play both ways in the pros — but not full time. Elway said he thinks Hunter will be primarily a corner in the NFL but with significant contributions on offense: "He's great at both. He's got great instincts, and that's what you need at corner." It's been five years since Elway announced he was dealing with Dupuytren's contracture, a chronic condition that typically appears after age 40 and causes one or more fingers to permanently bend toward the palm. Elway's ring fingers on both hands were originally affected and he said now the middle finger on his right hand is starting to pull forward. So, he'll get another injection of a drug called Xiaflex, which is the only FDA-approved non-surgical treatment, one that he's endorsing in an awareness campaign for the chronic condition that affects 17 million Americans. The condition can make it difficult to do everyday tasks such as shaking hands or picking up a coffee mug. Elway said what bothered him most was "I couldn't pick up a football and I could not imagine not being able to put my hand around a football." Get local news delivered to your inbox!

Bayer Leverkusen manager Xabi Alonso has confirmed that Victor Boniface sustained a minor injury during Nigeria’s 2-1 loss to Rwanda in a 2025 Africa Cup of Nations qualifying match at the Godswill Akpabio International Stadium in Uyo on Monday, November 18. Boniface featured for 89 minutes before being replaced by Umar Sadiq. Despite his efforts, the forward struggled to make an impact, extending his goal drought for the Super Eagles in official matches. Since his national team debut in 2023, Boniface has appeared in eleven games without finding the back of the net. Speaking at Friday’s pre-match press conference ahead of his side’s Bundesliga match against Heidenheim, Xabi Alonso confirmed that Boniface sustained a minor injury while on international duty with the Super Eagles. However, the former midfielder of Real Madrid and Liverpool was cautious about providing a recovery timeline. “He has a small injury in his thigh muscles,” Alonso was quoted as saying by Allgemeine Zeitung. “But it won’t be for six to eight weeks. We hope that he can play again this year. We now have to wait and see how he recovers.” The injury rules Boniface out of Bayer Leverkusen’s Bundesliga clash against FC Heidenheim at the BayArena on Saturday, as well as their crucial UEFA Champions League fixture against Red Bull Salzburg on Tuesday. Boniface’s absence will be a significant blow to Leverkusen’s campaign, as the team is battling to retain their Bundesliga title while pushing for a spot in the UEFA Champions League quarter finals. The Nigerian forward has been a key player for Die Werkself, contributing eight goals and providing one assist in fifteen games across all competitions.Trump expected to argue he has presidential immunity now, as president-elect, in new bid to dismiss hush-money case

Neurons are the fundamental building blocks of the brain. They share information through electrical signals. After receiving a stimulus, the neurons are activated via changes in membrane voltage. This induces quick variations in membrane voltage that travel through the cell as an electrical signal. Subsequently, intracellular calcium varies as a result of these modifications in membrane voltage. In the past, intrusive electrode approaches were needed to measure membrane voltage. Scientists have employed fluorescent proteins sensitive to calcium ions as a non-invasive way to assess neuron activity indirectly. However, because these techniques have usually been investigated independently, it is challenging to comprehend the real-time interactions between membrane voltage and calcium activity in living animals. Researchers from Kyushu University collaborated with Kyushu Institute of Technology’s Faculty of Computer Science and Systems Engineering to create a technique that allows them to simultaneously detect intracellular calcium and membrane voltage in living animal neurons. Researchers used high-speed imaging at 250 frames per second and sophisticated image processing to detect minute changes in the fluorescence intensity of calcium ion and membrane voltage sensors. This new method provides a more comprehensive understanding of neuron function, revealing that the two signals—calcium activity and membrane voltage—encode distinct information related to sensory stimuli. The team mainly focused on how olfactory neurons in Caenorhabditis elegans respond to odorants. They found that these neurons change their membrane voltage and intracellular calcium levels when exposed to odors. These signals are also found to encode separate information. Intracellular calcium levels showed the concentration of the odor, whereas membrane voltage showed its existence. By analyzing both signals simultaneously, the researchers were able to understand better how the brain interprets and distinguishes sensory inputs. The team also identified two ion channels essential for changing membrane voltages triggered by sensory stimulation. A protein called ODR-3 found to play a crucial role in stabilizing membrane voltage. This mechanism prevents neurons from firing in response to irrelevant stimuli and helps regulate the timing and intensity of reactions to odors. In the future, simultaneous membrane voltage and intracellular calcium measurements could be extended to neurons in more complex animals or different types of neurons, offering potential insights into how information is coded within neural circuits. Senior author Professor Takeshi Ishihara from Kyushu University’s Faculty of Science said , “These high-speed simultaneous measurements reveal the different functions of the membrane voltage and intracellular calcium ion signals induced by the sensory stimuli. These findings could lead to a better understanding of sensory processing in the central nervous system, in simple model systems like nematodes and higher organisms.” Journal Reference:

AP Sports SummaryBrief at 3:39 p.m. ESTLukas Kübler scored a brace, but Freiburg had to endure late pressure on their way to a 3-2 win against VfL Wolfsburg in the Bundesliga. Freiburg built a comfortable lead thanks to Kübler's brace and Michael Gregoritsch's effort, but Jonas Wind and Mattias Svanberg scored late goals for Wolfsburg on Friday. The match came down to some thrilling final minutes, with Freiburg having a goal ruled out in stoppage time, but still holding on to the three points and ending Wolfsburg's run of four consecutive league wins. Freiburg moved up to fifth in the standings, while Wolfsburg dropped to sixth. There were good chances at each end, with Kamil Grabara saving Ritsu Doan's effort for Freiburg in the 17th minute and Noah Atubolu diving to stop Konstantinos Koulierakis's header and deny Wolfsburg the opener in the 23rd. It was Freiburg, however, who found the net first. Vincenzo Grifo swung in a corner that Lucas Höler stylishly flicked to Kübler, who drove it home from close range in the 42nd. Kübler was on target again in the 51st heading in Gregoritsch's assist also from close range. Grifo almost got the third immediately after, but that eventually came in the 60th as Gregoritsch played a one-two with Doan before completing a delightful finish into the net. Freiburg thought the game was practically won, but were caught off guard when Wind pulled one back for Wolfsburg in the 75th and Svanberg added a second in the 83rd. The game was pretty much open in the final minutes and Freiburg even found the net again in stoppage time but Höler's effort was ruled out because he handled the ball as he slid to take it away from the goalkeeper before poking it into the goal.

6 tips to celebrate holidays with someone living with dementia