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paano maglaro ng fortune gems SOMERVILLE, Mass.--(BUSINESS WIRE)--Dec 8, 2024-- bluebird bio, Inc. (Nasdaq: BLUE) today announced new and updated data from LYFGENIATM (lovotobegligene autotemcel, or lovo-cel) gene therapy for patients with sickle cell disease who have a history of vaso-occlusive events (VOEs). The data will be presented at the 66 th American Society of Hematology (ASH) Annual Meeting and Exposition in an oral presentation on Sunday, December 8 at 9:30 a.m. Pacific Time and a poster presentation on Sunday, December 8 at 6 p.m. Pacific Time. As of July 2024, 70 patients were treated across the full lovo-cel clinical development program, with follow-up beyond 9 years in the earliest treated patients. “Data presented at ASH demonstrate that the potentially transformative benefits of LYFGENIA are sustained through additional long-term follow-up and consistent across sub-populations, including patients with overt stroke, not studied in any other clinical development program of gene therapy for sickle cell disease.” said Richard Colvin, M.D., Ph.D., chief medical officer, bluebird bio. “These data continue to distinguish LYFGENIA as the most deeply studied gene therapy for sickle cell disease, with the most patients treated, longest follow-up, and broadest range of clinical presentations evaluated across the field.” Updated efficacy data continue to support sustained, transformational impact on VOE burden and hematologic markers of disease An update on clinical response to lovo-cel in patients living with sickle cell disease focused on 58 patients who received lovo-cel in the HGB-206 Group C (n=36) and HGB-210 (n=22) studies, following enhancements to the manufacturing and treatment protocols, will be presented in Oral Presentation #511: An Update on Lovotibeglogene Autotemcel (lovo-cel) Clinical Trials for Sickle Cell Disease (SCD) and Analysis of Early Predictors of Response to Lovo-cel. Median follow-up time was 47.7 months (4.0 years), with 15 study participants having 5 or more years of follow-up. Stacy Rifkin-Zenenberg, DO, Hackensack Meridian Health said: “These data demonstrate that the significant clinical benefits of lovo-cel for people living with sickle cell disease are durable through continued long-term follow-up. Additionally, the number of patients treated, and duration of follow-up, has enabled detailed exploration of the pharmacology and mechanism of action of LVV gene therapy for sickle cell disease, providing even greater support that one-time treatment with lovo-cel has the potential to permanently address the underlying cause of sickle cell disease.” As of the July 2024 cutoff date, all patients continued to have stable production of anti-sickling adult hemoglobin after infusion through last follow-up (median >40% HbA T87Q ) and total Hb at last visit was 12.4 (6.6, 15.1) g/dL and was stable without transfusion support post engraftment. VOEs and severe vaso-occlusive events (sVOEs) were eliminated or significantly reduced in all patients. Specific findings include: The safety profile of the lovo-cel treatment regimen was generally consistent with underlying sickle cell disease and the known effects of myeloablative conditioning. There were no cases of graft failure or graft-versus-host disease (GVHD), no vector-related complications, and no insertional oncogenesis. For complete safety information please refer to the U.S. Prescribing Information noted below. Data from patients with sickle cell disease and a history of overt stroke show no recurrence of stroke following treatment with lovo-cel The first focused analysis of the clinical impact of lovo-cel on patients with sickle cell disease with a history of stroke, including overt stroke, will be presented in Poster Presentation #3576: Participants with a History of Stroke in Lovotibeglogene Autotemcel (lovo-cel) Clinical Trials. Data showed that patients with a history of overt stroke remained stable without recurrent stroke up to 9 years post-treatment (n=6), with median follow-up of 6.5 years. Jennifer Jaroscak, MD, Director, Pediatric Non-Malignant Transplant, Medical University of South Carolina, said “We are extremely pleased to report that no study participants with a history of overt or silent stroke experienced recurrent strokes following treatment with lovo-cel gene therapy, despite discontinuing transfusions. This finding is remarkable, as these patients face an exceedingly high risk of subsequent strokes, and transfusions alone provide only modest protection against secondary strokes. These data are unique in the field as lovo-cel is the only gene therapy for sickle cell disease with data on patients with a history of stroke.” Overt ischemic stroke is a devastating complication of sickle cell disease and requires lifelong chronic transfusions or allogeneic hematopoietic stem cell transplantation, which carry significant risk of complications. One in four patients living with sickle cell disease have a stroke by age 45. Other clinical outcomes in patients with a history of stroke—including expression of gene therapy derived anti-sickling hemoglobin (HBA T87Q ), improvements in total hemoglobin, and impact on other hematologic markers—were consistent with those patients’ respective study populations (HGB-206 Group A and HGB-206 Group C). The analysis also included 21 patients who had evidence of silent stroke based on available MRI data at screening. In this cohort there were no reports of recurrent overt or silent stroke among patients with follow-up MRIs, with a median 3.5 years follow-up (.48, 6.88 years). Silent ischemic stroke adversely affects neurocognitive function and is associated with increased risk of overt stroke. It occurs in an estimated 39% of patients with sickle cell disease. Safety findings for participants with a history of overt stroke did not differ from that in the overall treatment group. No increase in hypertension, bleeding issues, prolonged thrombocytopenia or catheter-related thromboses were observed. As previously reported, cases of acute myeloid leukemia were observed in two patients from the HGB-206 Group A cohort who were treated with an earlier version of the therapy prior to enhancements to the treatment and manufacturing processes. Both patients died due to aforementioned leukemia. About LYFGENIATM (lovotibeglogene autotemcel) or lovo-cel LYFGENIA is a one-time ex-vivo lentiviral vector gene therapy approved for the treatment of patients 12 years of age or older with sickle cell disease and a history of vaso-occlusive events (VOEs). LYFGENIA works by adding a functional β-globin gene to patients’ own hematopoietic (blood) stem and progenitor cells (HSPCs). Durable production of adult hemoglobin with anti-sickling properties (HbAT87Q) is possible following successful engraftment. HbAT87Q has a similar oxygen-binding affinity to wild-type HbA, limits sickling of red blood cells and has the potential to reduce VOEs. The Phase 1/2 HGB-206 study of LYFGENIA is complete and the Phase 3 HGB-210 study evaluating LYFGENIA is ongoing. bluebird bio is also conducting a long-term safety and efficacy follow-up study (LTF-307) for patients with sickle cell disease who have been treated with LYFGENIA in bluebird bio-sponsored clinical studies. Indication LYFGENIA is indicated for the treatment of patients 12 years of age or older with sickle cell disease and a history of vaso-occlusive events (VOEs). Limitations of Use Following treatment with LYFGENIA, patients with α-thalassemia trait (-α3.7/-α3.7) may experience anemia with erythroid dysplasia that may require chronic red blood cell transfusions. LYFGENIA has not been studied in patients with more than two α-globin gene deletions. Important Safety Information Boxed WARNING: HEMATOLOGIC MALIGNANCY Hematologic malignancy has occurred in patients treated with LYFGENIA. Monitor patients closely for evidence of malignancy through complete blood counts at least every 6 months and through integration site analysis at Months 6, 12, and as warranted. Hematologic Malignancy Hematologic malignancy has occurred in patients treated with LYFGENIA (Study 1, Group A). At the time of initial product approval, two patients treated with an earlier version of LYFGENIA using a different manufacturing process and transplant procedure (Study 1, Group A) developed acute myeloid leukemia (AML). One patient with α-thalassemia trait (Study 1, Group C) has been diagnosed with myelodysplastic syndrome (MDS). The additional hematopoietic stress associated with mobilization, conditioning, and infusion of LYFGENIA, including the need to regenerate the hematopoietic system, may increase the risk of a hematologic malignancy. Patients with sickle cell disease have an increased risk of hematologic malignancy as compared to the general population. Patients treated with LYFGENIA may develop hematologic malignancies and should have lifelong monitoring. Monitor for hematologic malignancies with a complete blood count (with differential) at least every 6 months for at least 15 years after treatment with LYFGENIA, and integration site analysis at Months 6, 12, and as warranted. In the event that a malignancy occurs, contact bluebird bio at 1-833-999-6378 for reporting and to obtain instructions on collection of samples for testing. Post-Marketing Long Term Follow-Up Study: Patients who intend to receive treatment with LYFGENIA are encouraged to enroll in the study, as available, to assess the long-term safety of LYFGENIA and the risk of malignancies occurring after treatment with LYFGENIA by calling bluebird bio at 1-833-999-6378. The study includes monitoring (at pre-specified intervals) for clonal expansion. Delayed Platelet Engraftment Delayed platelet engraftment has been observed with LYFGENIA. Bleeding risk is increased prior to platelet engraftment and may continue after engraftment in patients with prolonged thrombocytopenia. Two patients (4%) required more than 100 days post treatment with LYFGENIA to achieve platelet engraftment. Patients should be made aware of the risk of bleeding until platelet recovery has been achieved. Monitor patients for thrombocytopenia and bleeding according to standard guidelines. Conduct frequent platelet counts until platelet engraftment and platelet recovery are achieved. Perform blood cell count determination and other appropriate testing whenever clinical symptoms suggestive of bleeding arise. Neutrophil Engraftment Failure There is a potential risk of neutrophil engraftment failure after treatment with LYFGENIA. Neutrophil engraftment failure is defined as failure to achieve three consecutive absolute neutrophil counts (ANC) ≥ 0.5 × 109 cells/L obtained on different days by Day 43 after infusion of LYFGENIA. Monitor neutrophil counts until engraftment has been achieved. If neutrophil engraftment failure occurs in a patient treated with LYFGENIA, provide rescue treatment with the back-up collection of CD34+ cells. Insertional Oncogenesis There is a potential risk of lentiviral vector-mediated insertional oncogenesis after treatment with LYFGENIA. Hypersensitivity Reactions Allergic reactions may occur with the infusion of LYFGENIA. The dimethyl sulfoxide (DMSO) or dextran 40 in LYFGENIA may cause hypersensitivity reactions, including anaphylaxis. Anti-retroviral Use Patients should not take prophylactic HIV anti-retroviral medications for at least one month prior to mobilization and until all cycles of apheresis are completed. There are some long-acting anti-retroviral medications that may require a longer duration of discontinuation for elimination of the medication. If a patient is taking anti-retrovirals for HIV prophylaxis, confirm a negative test for HIV before beginning mobilization and apheresis of CD34+ cells. Hydroxyurea Use Patients should not take hydroxyurea for at least 2 months prior to mobilization and until all cycles of apheresis are completed. If hydroxyurea is administered between mobilization and conditioning, discontinue 2 days prior to initiation of conditioning. Iron Chelation Drug-drug interactions between iron chelators and the mobilization process and myeloablative conditioning agent must be considered. Iron chelators should be discontinued at least 7 days prior to initiation of mobilization or conditioning. Do not administer myelosuppressive iron chelators (e.g., deferiprone) for 6 months post-treatment with LYFGENIA. Non-myelosuppressive iron chelation should be restarted no sooner than 3 months after LYFGENIA infusion. Phlebotomy can be used in lieu of iron chelation, when appropriate. Interference with PCR-based Testing Patients who have received LYFGENIA are likely to test positive by polymerase chain reaction (PCR) assays for HIV due to integrated BB305 LVV proviral DNA, resulting in a possible false-positive PCR assay test result for HIV. Therefore, patients who have received LYFGENIA should not be screened for HIV infection using a PCR-based assay. Adverse Reactions The most common adverse reactions ≥ Grade 3 (incidence ≥ 20%) were stomatitis, thrombocytopenia, neutropenia, febrile neutropenia, anemia, and leukopenia. Three patients died during LYFGENIA clinical trials; one from sudden cardiac death due to underlying disease and two from acute myeloid leukemia who were treated with an earlier version of LYFGENIA using a different manufacturing process and transplant procedure (Study 1, Group A). Pregnancy/Lactation Advise patients of the risks associated with myeloablative conditioning agents, including on pregnancy and fertility. LYFGENIA should not be administered to women who are pregnant, and pregnancy after LYFGENIA infusion should be discussed with the treating physician. LYFGENIA is not recommended for women who are breastfeeding, and breastfeeding after LYFGENIA infusion should be discussed with the treating physician. Females and Males of Reproductive Potential A negative serum pregnancy test must be confirmed prior to the start of mobilization and re-confirmed prior to conditioning procedures and before LYFGENIA administration. Women of childbearing potential and men capable of fathering a child should use an effective method of contraception (intra-uterine device or combination of hormonal and barrier contraception) from start of mobilization through at least 6 months after administration of LYFGENIA. Advise patients of the options for fertility preservation. Please see full Prescribing Information for LYFGENIA including Boxed WARNING and Medication Guide . About bluebird bio, Inc. bluebird bio is pursuing curative gene therapies to give patients and their families more bluebird days. Founded in 2010, bluebird has been setting the standard for gene therapy for more than a decade—first as a scientific pioneer and now as a commercial leader. bluebird has an unrivaled track record in bringing the promise of gene therapy out of clinical studies and into the real-world setting, having secured FDA approvals for three therapies in under two years. Today, we are proving and scaling the commercial model for gene therapy and delivering innovative solutions for access to patients, providers, and payers. With a dedicated focus on severe genetic diseases, bluebird has the largest and deepest ex-vivo gene therapy data set in the field, with industry-leading programs for sickle cell disease, β-thalassemia and cerebral adrenoleukodystrophy. We custom design each of our therapies to address the underlying cause of disease and have developed in-depth and effective analytical methods to understand the safety of our lentiviral vector technologies and drive the field of gene therapy forward. bluebird continues to forge new paths as a standalone commercial gene therapy company, combining our real-world experience with a deep commitment to patient communities and a people-centric culture that attracts and grows a diverse flock of dedicated birds. Forward-Looking Statements This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. All statements that are not statements of historical facts are, or may be deemed to be, forward-looking statements, such as statements regarding the therapeutic potential of LYFGENIA. Such forward-looking statements are based on historical performance and current expectations and projections about bluebird’s future goals, plans and objectives and involve inherent risks, assumptions and uncertainties, including internal or external factors that could delay, divert or change any of them in the next several years, that are difficult to predict, may be beyond bluebird’s control and could cause bluebird’s future goals, plans and objectives to differ materially from those expressed in, or implied by, the statements. No forward-looking statement can be guaranteed. Forward-looking statements in this press release should be evaluated together with the many risks and uncertainties that affect bluebird bio’s business, particularly those identified in the risk factors discussion in bluebird bio’s Annual Report on Form 10-K for the year ended December 31, 2023, as updated by its subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the SEC. These risks and uncertainties include, but are not limited to: the risk that the efficacy and safety results from bluebird’s prior and ongoing clinical trials will not continue or be seen in the commercial context; the risk that there is not sufficient patient demand or payer reimbursement to support continued commercialization of LYFGENIA; the risk of insertional oncogenic or other safety events associated with lentiviral vector, drug product, or myeloablation, including the risk of hematologic malignancy; and the risk that bluebird’s products, including LYFGENIA, will not be successfully commercialized. The forward-looking statements included in this document are made only as of the date of this document and except as otherwise required by applicable law, bluebird bio undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, changed circumstances or otherwise. View source version on businesswire.com : https://www.businesswire.com/news/home/20241208134842/en/ CONTACT: Investors: Courtney O’Leary, 978-621-7347 coleary@bluebirdbio.com Media: Jess Rowlands, 857-299-6103 jess.rowlands@bluebirdbio.com KEYWORD: MASSACHUSETTS UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: SCIENCE OTHER SCIENCE BIOTECHNOLOGY RESEARCH GENERAL HEALTH HEALTH GENETICS OTHER HEALTH SOURCE: bluebird bio, Inc. Copyright Business Wire 2024. PUB: 12/08/2024 12:30 PM/DISC: 12/08/2024 12:30 PM http://www.businesswire.com/news/home/20241208134842/en Copyright Business Wire 2024.None

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A brand new, blank page in —or Google Sheets or Google Slides—can be daunting. Where to begin? What to say? One way of getting your next project moving is to load up one of the dozens of file templates provided in Docs, Sheets, and Slides. Not only do they give you a solid start with whatever you’re working on, they also give you a better idea of the capabilities of these online office tools. You might come across document types or layout features that you’d never known about. Templates are available across Google Docs, Google Sheets, and Google Slides (and a bunch of new ones ), but we’ll focus on Google Docs here—the approach for finding and setting up templates is very similar in the other web apps too. In , “templates help users save time since they don’t have to build documents from scratch, create more uniform, high-quality, visually appealing documents, and enable them to be more productive with the latest Docs features in their daily processes.” And getting started is simple. There are a few different ways to create a template. If you’re in on the web, you can click , which will bring up the template picker. You can also head to the dedicated portal page, where the templates are listed above your recent documents (click to see more). Templates are split up into sections such as letters, resumes, and newsletters, so make it easier to find something suitable—though of course there’s nothing to stop you opening a template created for one purpose and then using it for something else. Every part of a template can be edited, just like a normal document. Beyond the thumbnails and descriptions of each template, there’s no way to preview what a template looks like other than by opening it up and having a look (you can always delete the document later). Note that certain templates include a variety of page designs within them, so scroll down to see everything that’s on offer. When you’ve found something you think you like the look of, click on the template document to create the document thumbnail. You’ll get a new document based on the template in your Google Drive, with a generic title attached to it. Any subsequent changes you now make are saved to the new document—you won’t overwrite the template. Every part of a template can be edited, so you’re free to keep as much or as little of it as you want: You can adjust font styles and sizes, picture placement, paragraph spacing, and everything else that can be changed in a normal document. You won’t find anything locked or fixed just because you’re using a template. If there’s an image in the template, for example, click on it to bring up some alignment and text wrapping options underneath. On the same small toolbar that pops up, click the three dots then to see every property of the image, and to make changes where needed. You can rotate or recolor it, for example. You can replace template text anywhere in the document just by selecting it, and then typing out new text—if you’ve got the selection parameters right, the formatting should be retained. If you make a mistake, you can always use the undo reverse arrow button on the toolbar (or hit on Windows or on macOS). Another option is to open up the same template again and restart from scratch, of course. Templates can be thought of as giving you a solid foundation for the rest of your document, and saving you some time when it comes to formatting and layout—though they’re not going to do everything for you. You still get plenty of opportunity to stamp your own style on the various document properties, and adapt it to your needs. You can actually use any of your documents as a template, though they’re not officially labeled as such—it means you can use something you’ve made as a base for creating new files (you could create a custom company sales report template, for instance). Open the existing document you want to build on, then choose .

Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. The Carter Center said the 39th president died in Plains, Georgia, surrounded by his family. Carter had been in home hospice care since February 2023 after a series of short hospital stays. Carter, a Democrat, served a single term from 1977 to 1981, losing a reelection bid to Ronald Reagan. Despite his notable achievements as a peacemaker, Carter’s presidency is largely remembered as an unfulfilled four years shaken by blows to America’s economy and standing overseas. His most enduring legacy, though, might be as a globetrotting elder statesman and human rights pioneer during an indefatigable 43-year “retirement.” President Joe Biden said in a statement that “America and the world lost an extraordinary leader, statesman and humanitarian” as well as a man of “great character and courage, hope and optimism.” “With his compassion and moral clarity, he worked to eradicate disease, forge peace, advance civil rights and human rights, promote free and fair elections, house the homeless, and always advocate for the least among us. He saved, lifted, and changed the lives of people all across the globe,” Biden said, and officially ordered a state funeral to be held in Washington, DC. President-elect Donald Trump urged everyone to keep the Carter family in their prayers. “Those of us who have been fortunate to have served as President understand this is a very exclusive club, and only we can relate to the enormous responsibility of leading the Greatest Nation in History,” Trump wrote on Truth Social. “The challenges Jimmy faced as President came at a pivotal time for our country and he did everything in his power to improve the lives of all Americans. For that, we all owe him a debt of gratitude.” Carter became the oldest living former president when he surpassed the record held by the late George H.W. Bush in March 2019. Carter’s beloved wife, Rosalynn, died in November 2023. They had been inseparable during their 77-year marriage, and after she passed away, the former president said in a statement that “as long as Rosalynn was in the world, I always knew somebody loved and supported me.” The former president attended his wife’s memorial events, including a private burial and a televised tribute service in Atlanta, where he was seated in the front row in a reclined wheelchair. He did not deliver any remarks. Former U.S. president Jimmy Carter smiles during an interview in New York, Monday, Jan. 26, 2009. (AP Photo/Diane Bondareff) Carter took office in 1977 with the earnest promise to lead a government as “good and honest and decent and compassionate and filled with love as are the American people” following what had started as an unlikely long-shot bid for the Democratic Party’s nomination. The Southerner with a flashing smile did enjoy significant successes, particularly abroad. He forged a rare, enduring Middle East peace deal between Israel and Egypt that stands to this day, formalized President Richard Nixon’s opening to communist China and put human rights at the center of U.S. foreign policy. But Carter was ultimately felled by a 444-day hostage crisis in Iran, in which revolutionary students flouted the U.S. superpower by holding dozens of Americans in Tehran. The feeling of U.S. malaise triggered by the crisis was exacerbated by Carter’s domestic struggles, including a sluggish economy, inflation and an energy crisis. At times, Carter’s principled moral tone and determination to strip the presidency of ostentation, such as by selling the official yacht, Sequoia, seemed to verge on sanctimony. But out of office, Carter won admiration by living his values. Just a day after one of several falls he suffered in 2019, he was back out building homes for Habitat for Humanity, even with an ugly black eye and 14 stitches — and teaching Sunday school as he had done several hundreds of times . The devout Southern Baptist’s life’s work was only just beginning when he limped out of the White House, humiliated by Reagan’s 1980 Republican landslide, in which the incumbent won only six states and the District of Columbia. “As one of the youngest of former presidents, I expected to have many useful years ahead of me,” Carter wrote in his 1982 memoir, “Keeping Faith.” He proved as good as his word, going on to become a humanitarian icon, perhaps more popular outside the United States than he was at home. Over four decades, Carter, Rosalynn and his Atlanta-based organization monitored hot-spot elections, negotiated with despots, battled poverty and homelessness, fought disease and epidemics, and promoted public health in the developing world. In the process, Carter did nothing less than reinvent the concept of the post-presidency, blazing a philanthropic path since adopted by successors such as Bill Clinton and, in Africa, George W. Bush. His efforts on behalf of his Carter Center, founded to “wage peace, fight disease and build hope,” yielded a Nobel Peace Prize in 2002. Even into old age, Carter remained a polarizing political figure. He was an uneasy member of the ex-presidents’ club, sometimes frustrating successors like Clinton and criticizing the foreign policies of George W. Bush and Barack Obama, and of U.S. allies such as Israel. In recent years, he came full circle as he warned of the corrosive impact on American politics of a scandal-plagued White House — just as he did when his critique of the Nixon era helped him beat the disgraced Republican ex-president’s unelected successor, Gerald Ford, in 1976. (After Carter left office, he and Ford became close friends.) In September 2019, Carter warned Americans against reelecting Trump. “I think it will be a disaster to have four more years of Trump,” he said. In the subsequent presidential election, with Trump again on the ballot, Carter’s grandson Jason Carter told The Atlanta Journal-Constitution this year that the former president wanted to live long enough to cast a ballot for Democratic nominee Kamala Harris. He did just that, voting by mail for the vice president, who lost to Trump in November. After losing reelection, his work at the Carter Center became a great consolation. The ex-president said in a moving news conference detailing a cancer diagnosis in August 2015 that being president had been the highlight of his political career, even if it ended prematurely — though he would not swap another four years in the White House for the joy he had taken after leaving office in working with the Carter Center. And he said he was at peace with his legacy after a rich, fulfilling life: “I think I have been as blessed as any human being in the world.” Carter also said at that August news conference that marrying Rosalynn was the “pinnacle” of his life. He is survived by four children — Jack, Chip, Jeff and Amy — 11 grandchildren and 14 great-grandchildren, according to the Carter Center. In April 2021, President Joe Biden and first lady Jill Biden visited the Carters at their home in Plains, after the former presidential couple was unable to travel to Washington for the 46th president’s inauguration. U.S. president Jimmy Carter, right, and Queen Elizabeth II stand with French President Valery Giscard d'Estaing, at Buckingham Palace in London, In this photo dated May 1977. (AP Photo) An unlikely president Carter had always seemed an unlikely president. No one gave the Georgia governor and former Navy submariner a hope when he launched his campaign for the White House. But Carter spent months crisscrossing the cornfields and small towns of Iowa, building support voter by voter. In many ways, his success created the political lore of the modern Iowa caucuses as a place where little-known outsiders — Obama, for instance — could build a grassroots campaign that could lead to the White House. Democrats have recently downgraded the Hawkeye State’s role in their nominating process, reasoning that its mostly White demographic doesn’t represent the diversity of their supporters or the nation. Timing is crucial for presidential hopefuls, and as it turned out, Carter proved to be the right man at the right time in 1976. The deep political wounds of the Watergate scandal, which had forced the resignation of Nixon, remained raw. The nation was still deeply cynical about politicians following the social dislocation of the Vietnam War. “I’ll never lie to you,” Carter promised voters, forging a public image as an honest, humble, God-fearing, racially inclusive son of the “New South.” “He was never embarrassed to have a Georgian accent or be in blue jeans and play horseshoes and softball,” said his biographer Douglas Brinkley. That down-to-earth persona of Carter proved alluring. He followed up victory in the Iowa caucuses with wins in New Hampshire and Florida, beating out Democratic candidates including George Wallace of Alabama, Morris Udall of Arizona and Jerry Brown of California. “My name is Jimmy Carter and I’m running for president,” Carter said, poking fun at his leap from obscurity as he accepted his party’s nomination at the 1976 Democratic convention in New York City, where he tapped Sen. Walter Mondale of Minnesota as his running mate. Carter’s openness was crucial to his appeal with voters — but occasionally, his truth-telling appeared off-key. On one such occasion, Carter admitted to Playboy that he had looked on women with lust and “committed adultery in my heart many times.” Jimmy Carter, his wife Rosalynn and daughter Amy, lower left, respond to a huge crowd that welcomed them to New York, July 10, 1976. (AP Photo) A focus on human rights Carter beat Ford by 297 to 240 electoral votes and vowed in his inaugural address to put universal rights at the center of U.S. foreign policy. “Our moral sense dictates a clear-cut preference for those societies which share with us an abiding respect for individual human rights. We do not seek to intimidate, but it is clear that a world which others can dominate with impunity would be inhospitable to decency and a threat to the well-being of all people,” he said. Carter’s most significant achievement as president was the Camp David Accords, reached after exhaustive negotiations between Egypt and Israel that peaked at the presidential retreat in Maryland. It was the first peace deal between the Jewish state and one of its Arab enemies. The agreement, signed by Carter, Israeli Prime Minister Menachem Begin and Egyptian President Anwar Sadat in 1978, called for a formal peace between the foes and the establishment of diplomatic relations. It resulted in the Israeli withdrawal from the Sinai Peninsula and called for an Israeli exit from the West Bank and Gaza, with promised future negotiations to resolve the Palestinian question. While it did not settle the question of East Jerusalem, and subsequent violence and political unrest between Israel and the Palestinians meant the deal’s full potential was never realized, the enduring peace between Israel and Egypt remains a linchpin of U.S. diplomacy in the region. In subsequent decades, Carter soured on the Israeli leadership, becoming deeply critical of what he saw as a failure to live up to obligations toward the Palestinians. He sparked controversy in 2006 by saying that Israel’s settlement policies on the West Bank were tantamount to the apartheid policies of South Africa. The Carter administration also forged progress outside the Middle East, in Latin America and Asia. He countered growing hostility to the United States throughout the Western Hemisphere by concluding the Panama Canal treaties in 1977, which would return the strategic waterway between the Pacific and Atlantic Oceans to the control of its host nation in 1999. There had been fears that the Panamanians, increasingly resentful of U.S. sovereignty, could trigger a showdown by closing the canal — a step that would have had significant economic and strategic consequences. Carter also built on Nixon’s achievement of opening China by formalizing an agreement to establish full diplomatic relations in January 1979. An iconic visit to the United States by a cowboy-hat-wearing Chinese leader Deng Xiaoping followed. The decision was a tough one for Carter and required him to sever formal diplomatic relations with the renegade government and U.S. ally in Taiwan — which had claimed to be the legitimate government of China — in favor of the communists in Beijing. That June, Carter and Soviet Premier Leonid Brezhnev signed the treaty concluding the second round of the Strategic Arms Limitation Talks (SALT II), which placed broad limits on strategic nuclear arms. Some analysts also give Carter credit for beginning the buildup of sophisticated weaponry that later helped Reagan outpace the Soviet Union and win the Cold War — a heavy political lift as the Pentagon remained unpopular in the aftermath of the Vietnam War. Democratic presidential candidate Jimmy Carter is escorted by Massachusetts Sen. Edward M. Kennedy, Sept. 30, 1976, as Carter landed at Boston's Logan Airport for a campaign stop on his New England tour. (AP Photo/Jeff Taylor) Crises at home and abroad At home, meanwhile, Carter established the Department of Energy and exhorted Americans to cut down on consumption amid an oil price spike. He installed solar panels on the White House roof. He also began the process of deregulating the airline and trucking industries. But in 1979, Carter did himself significant political damage in an extraordinary address to the nation on the energy crisis in which he listed criticisms of his presidency, painting a picture of a listless nation trapped in a moral and spiritual funk. “It is a crisis of confidence. It is a crisis that strikes at the very heart and soul and spirit of our national will. We can see this crisis in the growing doubt about the meaning of our own lives and in the loss of a unity of purpose for our nation,” Carter said. Ultimately, the speech came back to haunt Carter and made it easy for opponents, not least Reagan, to portray him as a pessimistic and uninspiring leader. Still, in the late 1970s, it seemed conceivable that Carter’s command of foreign policy at the height of the Cold War would give him a fair shot at a second term. But a swelling of revolutionary Islam — heralding a trend that would confound future presidents — conspired to sweep him out of the White House. In October 1979, the United States let the shah of Iran, Reza Pahlavi — who had been overthrown by the Iranian Revolution a few months earlier — enter the country for medical treatment. That infuriated Islamic revolutionaries who saw him as an oppressive US puppet and wanted him returned to Iran for trial. On November 4, a year before the U.S. election, students who supported the Islamic revolution seized the U.S. Embassy in Tehran and took 66 Americans hostage. The 444-day standoff transfixed the nation, souring the national mood day by day as television news bulletins tallied how long the hostages had been in custody. Gradually it dashed Carter’s hopes of a second term. His fortunes were also battered by a daring and ultimately disastrous rescue bid in which a U.S. helicopter carrying special forces crashed in the desert, killing eight U.S. servicemen. At the same time, the Cold War was approaching a pivotal point. After the Soviets invaded Afghanistan in December 1979, Carter decided to boycott the Summer Olympics in Moscow and asked the Senate to delay ratification of SALT II. As November 1980 approached, a sense of Soviet belligerence and the lengthening humiliation of the hostage crisis fostered an impression of U.S. power under siege. “It was a perfect storm of unpleasant events, and that inability of Carter to get those Iranian hostages released before the 1980 elections spelled doomsday,” Brinkley said. Carter wrote in his memoirs that his destiny was out of his hands as the election approached, but he prayed the hostages would be released. “Now, my political future might well be determined by irrational people on the other side of the world over whom I had no control,” he said. “If the hostages were released, I was convinced my election would be assured; if the expectations of the American people were dashed again, there was little chance I could win.” Throughout the campaign, Reagan berated Carter as an ineffectual leader consigning America to perpetual decline. “A recession is when your neighbor loses his job. A depression is when you lose yours. And recovery is when Jimmy Carter loses his,” Reagan charged. The actor-turned-California governor pulled off a stunning landslide on Election Day 1980, winning 489 electoral votes. In the final humiliation for Carter, on January 20, 1981, 20 minutes after Reagan was sworn in, Iran released the hostages. Humble beginnings Carter was born on October 1, 1924, to James Earl Carter Sr. and Lillian Gordy Carter, who lived in a house without electricity in the south Georgia village of Plains. The oldest of four children, he was the first future U.S. president to be born in a hospital. Growing up during the Great Depression in the segregated Deep South, Carter showed a flair for music, art and literature, and often played with African American children — a factor influencing his thoughts on integration that played out in his political career. Jimmy Carter as Ensign, USN, circa Second World War. (Photo by PhotoQuest/Getty Images) After studying reactor technology and nuclear physics at Union College in Schenectady, N.Y., Carter was assigned to the submarine force. The future peacemaker served in the Atlantic and Pacific fleets before he was tapped by Adm. Hyman Rickover, the crotchety “Father of the Nuclear Navy,” to serve as a senior officer of the pre-commissioning crew of the Seawolf, the second U.S. nuclear submarine. After leaving active Navy duty in 1953, Carter spent time raising his children, running the family peanut farm and taking his first political steps, winning election to the Georgia Senate in 1962. He lost the Democratic nomination to run for governor to segregationist Lester Maddox in 1966 but ran successfully for the same office four years later. Political energy undimmed Carter was 56 when he left the White House, and he soon looked for new outlets for his undimmed political energy. “In the presidency, he got a sense of the fact that the world can be changed, and it doesn’t take a government to change it; it can be changed one person at a time, one disease at a time, building one house at a time,” said Andrew Young, who was a U.S. ambassador to the United Nations under Carter. The former president and first lady visited more than 130 countries to meet with foreign leaders and other prominent individuals. Carter was still traveling after his 90th birthday. As recently as May 2015, Carter went to Guyana to monitor the country’s most important election in two decades. The Carter Center has observed more than 125 elections in 40 nations since its founding in 1982. “We try to fill vacuums in the world,” Carter told an audience at the center in 2010, “by doing things that others don’t want to do or cannot do because of diplomatic niceties. That’s part of bringing peace.” Sometimes that meant mixing with unsavory company. In 1994, the United States and North Korea were edging toward conflict over U.S. concerns that Pyongyang was building a nuclear weapon. Absent diplomatic relations between the two countries, President Clinton gave Carter and Rosalynn permission to travel to the isolated Stalinist state to meet its supreme leader, Kim Il-Sung. In exchange for dialogue with the United States, North Korea agreed to freeze its nuclear program, which defused the crisis — for a few years at least. The same year, Carter was credited with helping avert a U.S. invasion of Haiti and restoring President Jean-Bertrand Aristide to power. In 2002, he became the first former or sitting U.S. president since 1928 to visit Cuba, where he called on the United States to end its “ineffective” economic embargo and challenged President Fidel Castro to hold free elections, grant more civil liberties and improve human rights. In 2008, he met with leaders from the Palestinian militant organization Hamas, designated a terrorist group by the U.S. State Department, and from Syria. At times, Carter also criticized the United States in public. In a June 2012 op-ed in The New York Times, Carter accused the United States of “abandoning its role as the global champion of human rights.” He cited revelations that officials were targeting people — including U.S. citizens — for assassination abroad as “disturbing proof” that the nation’s stance on human rights had changed for the worse. Former State Sen. Jimmy Carter listens to applause at the Capitol in Atlanta on April 3, 1970, after announcing his candidacy or governor. In background, his wife Rosalyn holds two-year-old daughter Amy who joined in the applause. (AP Photo/Charles Kelly) An enduring partnership In the summer of 1945, Carter, then a fresh-faced U.S. Naval Academy student, met Eleanor Rosalynn Smith and, after their first date, told his mother, “She’s the girl I want to marry.” Rosalynn rejected his first proposal but accepted the second a few weeks later. They wed in 1946 and would eventually become the longest-married presidential couple in history. Carter was asked the secret of his enduring marriage on CNN’s “The Lead” in July 2015. “Rosalynn has been the foundation for my entire enjoyment of life. ... First of all, it’s best to choose the right woman, which I did. And secondly, we give each other space to do our own things,” Carter told CNN’s Jake Tapper. “We try to be reconciled before we go to sleep at night and try to find everything we can think of that we like to do together. So we have a lot of good times.” When he published his book “A Full Life” shortly before he was diagnosed with cancer in 2015, Carter contemplated his own mortality. He wrote that he was at peace with his accomplishments as president as well as his unrealized goals. He said he and Rosalynn were “blessed with good health and look to the future with eagerness and confidence, but are prepared for inevitable adversity when it comes.” This story has been updated with additional information. Tom Watkins and CNN’s Jeff Zeleny and Haley Talbot contributed to this report. Shopping Trends The Shopping Trends team is independent of the journalists at CTV News. We may earn a commission when you use our links to shop. Read about us. 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These LEGO Kits Are On Sale For Boxing Day 2024 The Waterpik Advanced Water Flosser Will Make Cleaning Your Teeth So Much Easier — And It's 41% Off For Boxing Day CTVNews.ca Top Stories Trudeau, Biden, Trump, other world leaders remember former U.S. president Jimmy Carter Former U.S. president and Nobel Peace Prize winner Jimmy Carter died Sunday at the age of 100. Upon news of his death, political figures and heads of state from around the world gave praise to Carter, celebrating his faith and time both in office and afterwards. BREAKING | Jimmy Carter, a one-term president who became a globe-trotting elder statesman, dies at 100 Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. 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Canada Eastern Ontario police arrest Scarborough resident found with nearly $50K of cocaine Police in eastern Ontario charged a Toronto resident who was allegedly in possession of hundreds of grams of cocaine earlier this month. Police, coroner investigating two deaths at Brantford, Ont. encampment An investigation is underway into the deaths of two people at an encampment in Brantford, Ont. TSB investigating airplane landing incident at Halifax airport The Transportation Safety Board of Canada says they are investigating an aircraft incident at the Halifax Stanfield International Airport that caused temporary delays to all flight operations Saturday night. 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World BREAKING | Jimmy Carter, a one-term president who became a globe-trotting elder statesman, dies at 100 Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. Plane crashes and bursts into flames while landing in South Korea, killing 179 A jetliner skidded off a runway, slammed into a concrete fence and burst into flames Sunday in South Korea after its landing gear apparently failed to deploy. All but two of the 181 people on board were killed in one of the country’s worst aviation disasters, officials said. Azerbaijan's president says crashed jetliner was shot down by Russia unintentionally Azerbaijan’s President Ilham Aliyev said Sunday that the Azerbaijani airliner that crashed last week was shot down by Russia, albeit unintentionally, and criticized Moscow for trying to 'hush up' the issue for days. Russian man arrested for allegedly running LGBTQ2S+ travel agency found dead in custody A Russian man arrested for allegedly running a travel agency for gay customers was found dead in custody in Moscow, rights group OVD-Info reported Sunday, amid a crackdown on LGBTQ2S+ rights in Russia. An Israeli airstrike near the Syrian capital kills 11, war monitor says An Israeli airstrike in the outskirts of Damascus on Sunday killed 11 people, according to a war monitor, as Israel continues to target Syrian weapons and military infrastructure even after the ouster of former president Bashar Assad. Trump appears to side with Musk, tech allies in debate over foreign workers roiling his supporters U.S. president-elect Donald Trump appears to be siding with Elon Musk and his other backers in the tech industry as a dispute over immigration visas has divided his supporters. 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Toronto Pedestrian taken to hospital after hit-and-run in Mississauga A pedestrian has been taken to the hospital following a hit-and-run in Mississauga Sunday. Suspect charged after woman found dead at Niagara Falls home A suspect has been charged after a woman was found dead inside her Niagara Falls home. BREAKING | Jimmy Carter, a one-term president who became a globe-trotting elder statesman, dies at 100 Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. 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BREAKING | Jimmy Carter, a one-term president who became a globe-trotting elder statesman, dies at 100 Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. Bell Capital Cup debuts sledge hockey division for children with disabilities The Bell Capital Cup entered its halfway point on Sunday and the long-running tournament continues to make history. Montreal BREAKING | Jimmy Carter, a one-term president who became a globe-trotting elder statesman, dies at 100 Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. Grocery prices to rise in 2025, report says Canadians are bracing for higher grocery bills in 2025, with a new report projecting food prices will increase by 3 to 5 per cent nationwide—and up to 5 per cent in Quebec. Here's how you can watch CTV News Montreal at Six on Sundays during the NFL season With CTV broadcasting NFL football games on Sundays this season, CTV News Montreal at Six will be broadcasting live on our website and the CTV News App. Edmonton 2 vehicles fall through ice at Sylvan Lake, promoting police warning RCMP issued a warning Saturday after two vehicles fell through the ice on Sylvan Lake. Ducks come from behind to beat visiting Oilers Ryan Strome scored the go-ahead goal at 17:24 of the third period, and the Anaheim Ducks rallied from a two-goal deficit for a 5-3 home-ice win over the Edmonton Oilers on Sunday. Edmonton to start up cold weather response plan Monday morning The City of Edmonton is activating its extreme weather response plan with the weather forecast calling for cold temperatures over the next eight days. Atlantic TSB investigating airplane landing incident at Halifax airport The Transportation Safety Board of Canada says they are investigating an aircraft incident at the Halifax Stanfield International Airport that caused temporary delays to all flight operations Saturday night. BREAKING | Jimmy Carter, a one-term president who became a globe-trotting elder statesman, dies at 100 Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. N.B. entrepreneur honours memory of mother with 'thank you' note legacy N.B. entrepreneur Emily Somers honours her mother with 'thank you' notes. Winnipeg Stolen vehicle chase ends in arrest, drug seizure A Winnipeg man has been charged with several offences after a police chase involving a stolen vehicle and hundreds of dollars worth of drugs. Fifth night of Hanukkah celebrated ahead of Manitoba Moose hockey game As Jewish people around the world mark the fifth night of Hanukkah, members of Winnipeg’s Jewish community brought the celebration to Canada Life Centre. Winnipeg hotel fire forces residents to evacuate A fire at a Winnipeg hotel forced residents to leave the building Sunday morning. Regina Regina police charge 2 youths in city's 6th homicide of 2024 Two Regina teens are facing murder charges in connection to the death of a Regina man on Boxing Day. Hockey talent showcased in Regina for Male U15, Top 160 tournament The last weekend of 2024 saw Saskatchewan's best hockey players under 15 years of age showing off their skills at the Co-operators Centre in Regina. Regina man showcases local bead supply business Jeramy Hannah recently began selling beading supplies, after he realized the beaders in his life were struggling with a lack of local vendors, prompting him to create a business called Bead Bro. Kitchener Are fluctuating temperatures here to stay this winter? Waterloo Region residents traded snow boots for raincoats this weekend as temperatures soared above seasonal norms. Portion of Highway 6 closed following collision in Ennotville, Ont. A portion of Highway 6 is closed Sunday evening following a collision in Ennotville, Ont., just north of Guelph. Police, coroner investigating two deaths at Brantford, Ont. encampment An investigation is underway into the deaths of two people at an encampment in Brantford, Ont. Saskatoon U18 provincials curling tournament underway in PA Teams from across Saskatchewan are in Prince Albert for the U18 curling provincials. Police made two arrests following a shooting in Saskatoon A swift response from Saskatoon police led to the arrest of a man and woman following a reported shooting Friday afternoon. Saskatoon fire crews battle house fire Saskatoon firefighters responded to a house fire on the 100 block of Klassen Crescent Friday afternoon. Northern Ontario Mississauga tow truck driver charged for impersonating a cop in northern Ont. A southern Ontario resident has been charged for allegedly impersonating a peace officer during a towing incident in northwestern Ontario. BREAKING | Jimmy Carter, a one-term president who became a globe-trotting elder statesman, dies at 100 Former U.S. president Jimmy Carter, a Georgia peanut farmer who vowed to restore morality and truth to politics after an era of White House scandal and who redefined post-presidential service, died Sunday at the age of 100. 'Pretty limited' options for Liberal MPs calling for leadership change As calls mount within the federal Liberal Party for Prime Minister Justin Trudeau to step down as leader, one political analyst says there’s little his detractors can do to force his hand. London Fatal crash in Middlesex County Middlesex County OPP attended the scene of a fatal motor vehicle collision in Strathroy-Caradoc early Sunday morning. New Year’s Eve in London’s Victoria Park You can ring in 2025 this Tuesday night at London’s free New Year’s Eve in the Park celebration. Can you help solve this cold case in Sarnia? Sarnia police are seeking the public’s help in finding any new leads for a cold case from over 20 years ago. Barrie Deluxe taxi goes up in flames in Barrie parking lot Some locals were quick to pull out their cellphones and capture a minivan as it went up in hot flames in a Barrie parking lot. Region under rainfall warning, fog advisory Many areas across Simcoe Muskoka, upper York Region and Grey County are under rainfall warnings and fog advisories as of Sunday morning. $47K in drugs seized, man arrested in alleged domestic assault Police in Owen Sound made one arrest and seized a ‘large’ quantity of multiple drugs after responding to an alleged domestic assault on Saturday. Windsor Crews battle two apartment fires in under two hours Windsor Fire and Rescue responded to two calls at Ouellette Avenue apartment buildings Sunday morning. 'Pretty limited' options for Liberal MPs calling for leadership change As calls mount within the federal Liberal Party for Prime Minister Justin Trudeau to step down as leader, one political analyst says there’s little his detractors can do to force his hand. Woman with outstanding warrant arrested in Chatham One person has been arrested after Chatham-Kent police officers conducted a traffic stop Saturday in Chatham. Vancouver Island Victoria police seek witnesses, additional victims after hit-and-run spree A woman is facing seven charges after allegedly committing multiple hit-and-run crashes in a stolen vehicle while impaired, according to police in B.C.'s capital. Online child exploitation spiked during lockdowns. Police worry it's here to stay Online predators are becoming increasingly resourceful in trolling media platforms where children gravitate, prompting an explosion in police case loads, said an officer who works for the RCMP Integrated Child Exploitation Unit in British Columbia. Vancouver man defrauded Chinese developers of US$500K, court rules A Vancouver man has been ordered to pay more than US$500,000 after a B.C. Supreme Court judge found he had defrauded the would-be developers of a real estate project in China of that amount. Kelowna B.C. team building 100 beaver 'starter homes' in the name of wetland preservation More than 70 manmade beaver dams have been installed in Interior waterways since the B.C. Wildlife Federation project launched last year with the goal of building 100 dams by the end of 2025. B.C. man charged with drug trafficking and weapons offences after CBSA investigation A resident of B.C.'s Interior has been charged with weapon and drug trafficking offences after an investigation launched by border agents at Vancouver International Airport earlier this year. B.C woman awarded nearly $750K in court case against contractor A B.C. woman has been awarded nearly $750,000 in damages in a dispute with a contractor who strung her along for a year and a half and failed to complete a renovation, according to a recent court decision. Lethbridge Lethbridge residents pay it forward as Salvation Army’s Kettle Campaign exceeds fundraising goal with $232K The Salvation Army surpassed what it considered to be an ambitious fundraising goal for this holiday season. Lethbridge fire crews greet Christmas putting down structure fire at oil change business Lethbridge firefighters started off Christmas morning responding to a major structure fire at an oil change business. Lethbridge Police investigating suspicious death inside motel room Lethbridge Police are investigating after a body was found inside a southside motel room on Saturday. Sault Ste. Marie Provincial police investigate fatal commercial vehicle crash in northwestern Ont. Ontario Provincial Police are investigating a fatal crash on Highway 17 between Sistonen's Corner to Upsala in northwestern Ontario. Mississauga tow truck driver charged for impersonating a cop in northern Ont. A southern Ontario resident has been charged for allegedly impersonating a peace officer during a towing incident in northwestern Ontario. Man shot by officer after firing at police car near Thunder Bay: SIU Ontario's Special Investigations Unit is probing a shooting near Thunder Bay in which a man was shot and wounded by a police officer on Boxing Day. N.L. Icebreaker on hand in Labrador to guide season's last freight arrivals by ferry A Canadian Coast Guard icebreaker is in central Labrador until Saturday to guide the Kamutik W ferry on its last freight deliveries of the season. Whooping cough in Canada: Outbreaks or case increases reported in these provinces Canadian health officials say they're seeing spikes in whooping cough cases in parts of the country as the U.S. deals with case numbers not seen in more than a decade. Her son needed help with addiction. Instead, he's spending Christmas in N.L. jail. As Gwen Perry prepares for a Christmas without contact from her son, who is locked inside a notorious St. John's, N.L., jail, she wants people to understand that many inmates need help, not incarceration. Stay Connected

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About 25 per cent of the population aged between 16 and 64 in Manchester — more than 100,000 people — were classed as “economically inactive” last year. This proportion is 4 percentage points higher than the average across the UK, and one in five people in the city’s working-age population claim out-of-work benefits. If Labour is to bring down Britain’s growing welfare bill, it must tackle the deepening worklessness crisis in cities such as Manchester. People on benefits in the southern suburb of Wythenshawe back Sir Keir Starmer and Liz Kendall’s bid to cut the bloated welfare system. Tracey Baxter, 54, a former airport worker, receives a range of disability benefits after being diagnosed with heart and lung conditions, high blood pressure and blood cancer.

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Jimmy Carter dies: The 39th U.S. president and global humanitarian was 100

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Slate Office REIT ( TSE:SOT.UN – Get Free Report )’s stock price rose 53.7% during mid-day trading on Friday . The company traded as high as C$0.65 and last traded at C$0.63. Approximately 754,588 shares traded hands during mid-day trading, an increase of 749% from the average daily volume of 88,912 shares. The stock had previously closed at C$0.41. Slate Office REIT Stock Performance The stock has a fifty day simple moving average of C$0.51 and a two-hundred day simple moving average of C$0.44. The company has a debt-to-equity ratio of 329.26, a quick ratio of 0.14 and a current ratio of 0.47. The stock has a market cap of C$50.64 million, a price-to-earnings ratio of -0.19 and a beta of 1.35. Slate Office REIT Company Profile ( Get Free Report ) Slate Office REIT is an open-ended real estate investment trust. The REIT's portfolio currently comprises 43 strategic and well-located real estate assets located primarily across Canada's major population centres including one downtown asset in Chicago, Illinois. The REIT is focused on maximizing value through internal organic rental and occupancy growth and strategic acquisitions. See Also Receive News & Ratings for Slate Office REIT Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Slate Office REIT and related companies with MarketBeat.com's FREE daily email newsletter .Jollof rice, a cherished culinary tradition in West Africa , boasts countless variations, each a delicious testament to the region's vibrant cultural tapestry. This savory one-pot rice delicacy, typically seasoned with tomatoes, onions, and chili peppers, holds a special place at celebrations and gatherings. With each country and individual household claiming their distinct jollof rice recipe, this versatile dish promises a unique gastronomic adventure with every serving. Nigerian jollof: A spicy delight Nigerian jollof rice packs a spicy punch with its bold, layered flavors. They use long-grain parboiled rice. It gets its bold flavor from curry powder, thyme, and ginger, with Scotch bonnet peppers serving as the real game-changer. Bay leaves are added for their distinctive fragrance. Paired with sweet fried plantains and smoky grilled chicken, it's not just a dish, but a whole meal. Ghanaian jollof: The perfect balance Ghanaian jollof rice shines with a well-rounded tomato taste and subtle smokiness, offering a less spicy but equally delicious alternative to the Nigerian version. Ghanaians opt for basmati or jasmine rice, resulting in a lighter, fluffier texture. The secret to Ghanaian jollof's depth lies in the addition of smoked fish or shrimp powder, lending a unique umami kick that sets it apart. Senegalese jollof: A cultural heritage Locally referred to as Thieboudienne , Senegalese jollof rice isn't just a dish, it is a cultural heritage of the nation. This variant is unique because it doesn't depend solely on tomato paste for its color, instead, it uses tamarind juice, which imparts a tangy taste. Additionally, it incorporates veggies like carrots, cabbage, and okra, ensuring the dish is not only flavorful but also healthy. Liberian jollof: A creamy twist The secret ingredient in Liberian jollof is coconut milk! It adds a creamy richness and hint of sweetness that sets this version apart. You'll also find a mix of meats (think chicken and beef) in Liberian jollof, but you can easily make it vegetarian by leaving these out. And, get this: Liberians love their jollof with sliced avocados on top! Talk about a refreshing twist. Tips for perfecting your jollof rice To master jollof rice, concentrate on rice choice and heat control. Opt for long-grain parboiled rice for its sturdiness in withstanding the sauce. Start cooking on high to develop flavors, then reduce to a low simmer to avoid burning the bottom. This technique guarantees evenly cooked, tasty rice without any sogginess.

S itting in a white armchair on the Sunday morning after Thanksgiving, the soft bayou light streaming into her family home, something is bugging Gypsy-Rose Blanchard. “It feels like a circus,” she tells Rolling Stone in her distinctive, high-pitched voice. All around her, there are family photos and reminders of people who love her. There’s a sign across from her that reaffirms this. Family: A little bit of crazy. A little bit of loud. And a whole lot of love. But she keeps no pictures of her mother around. Blanchard, 33, spent more than eight years incarcerated for her involvement in the 2015 murder of Clauddine “Dee Dee” Blanchard. Since she was released last year, the attention has been constant. “I’m not an animal in a cage,” she says. Blanchard’s private life is better now in the small bayou town where she lives, about an hour outside of New Orleans. She is staying at the home of her father, Rod, and stepmother, Kristy, and is experiencing a lot of new things — grocery shopping, paying bills, doing laundry. She just returned from Florida, where she spent the holiday with her boyfriend, Ken Urker, and swam in the ocean for the first time. “I got water in my mouth and was like, ‘Oh, it’s salty!’ I didn’t expect that,” she says in an almost childlike tone. The couple, who first met through a pen-pal program in 2017 and reconnected after her release, is expecting their first child — a daughter — in January. Blanchard hopes she can go to cosmetology school later on to become a hairdresser. But her life is anything but normal. In the near-decade since her then-boyfriend, Nicholas Godejohn, fatally stabbed Dee Dee at her Springfield, Missouri, home, Blanchard’s saga has become fodder for everything from long-form podcasts to prestige documentaries to a scripted Hulu series starring Patricia Arquette and Joey King, which she says she still hasn’t watched. “To be quite honest, I didn’t know how big this story was until I got out of prison,” she admits. Editor’s picks The 100 Best TV Episodes of All Time The 250 Greatest Guitarists of All Time The 500 Greatest Albums of All Time The 200 Greatest Singers of All Time While Godejohn was convicted of first-degree murder and sentenced to life without the possibility of parole, Blanchard was given 10 years in prison for second-degree murder, and was released last year after serving about seven. (She spent a year in a half incarcerated waiting for trial.) Since then, she’s been torn between reclaiming her life story and coming to grips with the fact that some of her legions of followers might be paying attention for the wrong reasons. “I don’t want people to follow me because of the crime that I committed,” Blanchard says. “I don’t want to have fans because they feel like what I did was right.” Dressed in a slouchy yellow sweater, she hands me her phone. (The left sleeve is pulled up to reveal a tattoo of a husky on her forearm, with Urker having a matching one.) The screen shows a photo, taken without Blanchard’s consent, of her in the waiting room of her OB-GYN’s office with Urker, which was subsequently posted to a Reddit forum dedicated to dragging her. On Facebook, she shows me, there’s a photo someone snapped of Blanchard talking to a teller at the bank, along with comments trolling her appearance, her relationship and the crime itself. When she was released in December 2023, Blanchard believed that she could — and would — live a normal life. “And then,” she says, “I started to understand that is not reality.” Instead, her reality is much more complicated. It’s why, she says, she felt compelled to tell her story in full. On Dec. 10, Blanchard will release her memoir, My Time to Stand , which details her mother’s suspected case of Munchausen syndrome by proxy — a mental illness in which a caretaker makes up fake symptoms or causes real ones to appear that a healthy child is sick — and the abuse Gypsy suffered as a result. (Her mother, for instance, subjected her to endless medical procedures for diseases she didn’t have.) Related Content Unraveling the 50-Year Mystery of the Body in the Basement Menendez Brothers' Aunts Beg Judge to Let Them Out as Hearing Pushed to Late January L.A. Elected a New District Attorney. What Does This Mean for the Menendez Brothers? A Jury Wouldn't Convict Karen Read. Now She Wants Her Charges Dismissed It also covers the family dysfunction and trauma she experienced as a child, from her grandfather’s sexual abuse of both her and her mother, to the lies her mother told to government agencies and charities to scam benefits, including a house from Habitat for Humanity. She talks about the men, including Godejohn, with whom she began relationships online, and the multiple attempts she made to escape from her mother’s home. All the while, Dee Dee was godlike to her, her sole caretaker who was always hovering. “Gypsy-Rose will never find true love,” Blanchard claims her mother would tell her. “Gypsy-Rose will never find happiness.” The memoir’s release comes at a time of radical change for Blanchard. In the past year, she divorced her ex-husband, whom she married in 2022; became pregnant; and had to learn life skills, like balancing a budget, that she was never taught growing up. While Blanchard’s story has been across numerous platforms, she says the memoir is the first time she has full control of her narrative and the events leading up to and after the murder. After years of trying to move away from the crime, she is returning to the scene in her memory and in her own words. An author’s note in the beginning of the book says that while some of Blanchard’s memories have faded, the memoir is “true to my memory, and these memories have shaped my perceptions, many of which are also shared here.” The book itself outlines the story of a young, poor girl growing up in Louisiana and Missouri, bound to a single mother who made Blanchard think that it was them against the world. To win, Dee Dee had to lie, cheat, and steal, with Blanchard as an accomplice to her mother’s fraud and a victim of her abuse. She worked with two co-writers for it, Melissa Moore and Michele Matrisciani, who began working with her when she was still in prison and uncertain of any early release. “She’s lived a lot of life, a life of ups and downs — but more ups than downs,” says her stepmother, Kristy, who’s been married to her father, Rod, for 25 years. “She’s doing all the things that her mom said she couldn’t do — falling in love, getting married, getting divorced, reuniting with the love of her life, having their child. And even cutting the grass or taking out the garbage, those are the things she couldn’t do.” Since her conviction, she’s appeared on The View , Dr. Phil , and The Kardashians , with both the Cut and Slate dubbing her “America’s sweetheart.” In the process, she’s become a polarizing figure. Her supporters maintain she is a survivor who has done her time and should be able to live a private life. On TikTok and Reddit, her detractors loudly flood the platforms with a mix of legitimate criticism, conspiracy theories, and unflattering memes, calling Blanchard a liar and grifter who is profiting from her crime. The memoir is also getting review-bombed on sites like Goodreads with one-star ratings before anyone has read a page. This reality can be depressing for Blanchard, who is preparing for possible protesters at a book-signing event in New Orleans later this month. She has publicly disavowed what she did to her mother, as well as supporters who feel killing her mom was somehow the cool thing to do. But each time someone secretly takes a photo of her in public or posts a video slamming her, she wonders if there is any path toward a normal life, or if she’s even capable of living such a life by the time she becomes a mother of her own. “When people come up to me and are like, ‘I don’t blame you, I would have done the same thing,’ I’m disgusted,” she says. “It’s not like I look back on my past and am proud of what I did. I’m very ashamed of it, so I honestly get offended whenever someone says things [to me] like that because they are missing the whole point.” DEE DEE’S SCREMS STAY with Blanchard. So does the total silence that followed the murder. “To this day, I have never seen [the] crime-scene pictures,” she tells Rolling Stone . “I heard her scream, but the aftermath of what happened is unknown to me.” When she was recording the audiobook for her memoir, Blanchard broke down recalling her breaking point leading to the death: When Dee Dee lied to doctors and pushed for an exploratory surgery on her larynx, which could have potentially silenced her voice — literally — forever. To Blanchard, it felt like her mother was lying to doctors as her way to cut her daughter’s throat. “I started to think if nothing happens, how old will I be until this stops? Will I be in my forties? Will I be in my fifties? Will I die?” she says. “That was the moment when I was like, ‘OK, something needs to happen right now.’” She then struggled recounting how she lay in a fetal position with her hands pressed over her ears, as Godejohn repeatedly stabbed Dee Dee as she called out for her daughter. In that moment, Gypsy couldn’t think about the years of abuse she suffered; she could only focus on her breathing. For a while, Blanchard had a recurring nightmare that had her reliving her mother’s murder each night, as an observer witnessing the crime. “I didn’t want to make [Dee Dee’s death] the sole point of the book, but I did want readers to understand that there is a level of trauma,” she says. “It’s not something that happens and then you just go back to your daily life and you’re fine. It’s something that doesn’t go away.” In the book, Blanchard examines her mother’s motivations, particularly how Dee Dee was keenly aware that she was creating a world of lies and lore from an early age. “I heard from her brothers, her sisters, that she was kind of the black sheep. She didn’t just quite fit in,” Blanchard says. “There were certain aspects of her personality that were manipulative [and] controlling. But there wasn’t enough awareness at the time [in] the Eighties [and] Nineties about mental health issues. So it just very much went undetected.” I ask Blanchard, who admits in the book that she was taught to live a life of deception, the greatest lie that Dee Dee told her. “This is gonna sound a little harsh,” Blanchard says. “But I think the greatest lie she ever told was that she loved me.” Matrisciani, one of the memoir’s co-writers, understood early on that Blanchard did not want to make the book a justification for murder as a response to lifelong physical, mental, and emotional abuse. “This is a young woman who is really trying to make sense of why things happened the way they did, and how things are not black and white,” Matrisciani tells Rolling Stone . “It’s very hopeful. It’s dark, but it’s hopeful.” Blanchard knows she’s not alone in the morbid club of people who murdered family members who they claim abused them. She hopes the Menendez brothers, who are serving life in prison without the possibility of parole for the 1989 murder of their parents, are granted their freedom. (A resentencing hearing for the brothers is scheduled for January .) “I feel like they have paid their dues to society. Thirty years is a long time,” Blanchard says. “I’m one of those people that feels that they did their time for the crime. Let them have their freedom. I am in support of anyone that has been a victim of abuse like that because it’s not something anyone should ever go through.” “When people come up to me and are like, ‘I don’t blame you, I would have done the same thing,’ I’m disgusted.” IT’S A LITTLE AFTER 9 a.m., and for now, the house — which is covered in portraits of the family, including the pregnancy photos of a smiling Blanchard and Urker basking in joy and golden-hour lighting — is relatively quiet. Later, the family will watch the Saints play the Rams, and put up Christmas decorations; white stockings already hang above the fireplace. In the coming days, a TV crew will arrive to shoot the second season of her Lifetime reality show, Gypsy Rose: Life After Lock Up . She’s planning to pre-sign hundreds of books ahead of the event in New Orleans, where online critics who don’t want her to profit off her past say they’re threatening to protest. “Nobody’s ever come up to me with anything negative to say,” Blanchard says. Leaning back in her green recliner, Kristy succinctly guesses why none of the online hate shows itself in-person: “They don’t have the balls.” Blanchard maintains that she doesn’t see herself as famous and never sought out attention. She can talk endlessly about how much the guilt, shame, and responsibility for her mother’s murder weigh on her, but that still doesn’t deter some young people from approaching the person they see as TikTok famous and saying they support her because she helped kill her mom. It leaves her in no-man’s land: appreciative of the support, but decrying the catalyst for why some of her fans are there in the first place. “There’s Gypsy-Rose Blanchard from the media and documentaries, and then there’s the Gypsy that my family knows, that my partner knows, that I know,” she says. “The two are in the same body, but I just kind of feel like nobody really knows the real me.” Blanchard knows that some people will never let her live down her sins or the sins of her mother. She says that she recently tried to volunteer for Habitat for Humanity, which built and gifted the home to Dee Dee after the mother and daughter lost their Louisiana home to Hurricane Katrina. But Blanchard says the organization declined her offer, in part because Lifetime wanted to film the experience for the reality show. “I did express that I would like to make amends for what my mom did, and I got rejected,” she tells me. “I’ve found that not everybody forgives.” (A spokesperson for Habitat for Humanity did not respond to a request for comment.) She also understands that there appears to be a disconnect between saying she wants a private and quiet life with her burgeoning career as a social-media influencer and reality-TV star. Blanchard has recently stayed in the headlines on gossip sites thanks to her posting the results of a paternity test to prove that Urker is the father and quell rumors that the child was her ex’s. “It’s how it is right now,” she says. “I don’t think the public will ever let me fade into obscurity altogether. I think there will always be curiosity about what I’m doing in my life. And I have come to accept it.” But after the show is finished filming what she says will be the last season, Blanchard wants to disconnect and plan her exit from the public eye. That off-ramp includes backing away from her public social media accounts, which she says she only uses for promotion these days, as well as raising her daughter, whom she and Urker plan to name Aurora. She eventually wants to get her own place and be closer to Urker, who lives in Dallas. Blanchard is also taking driver’s education, which terrifies her. “I’m very scared to drive because I’m like, what if I hit [someone], and it turns into a whole big thing, and I go back to prison?” she says. “I need to be responsible enough as a mom to do that.” As part of her consideration of motherhood, Blanchard must confront what she plans to tell her daughter about Dee Dee. Whether it’s on TikTok, the book, or her nightmares, her mother’s murder remains. When the time comes to talk to her daughter about who her grandmother was and what happened to her, Blanchard wants there to be no more lies. “I feel like [the book] is a nice segue into when Aurora is older, and a lot of people might give her shit or bully her over it,” she says. “In essence, this [book] is for her. This is so she can have a place of comfort that is safe for her.” Blanchard’s relationship with her mother was based on lies; now the adult, she plans to tell Aurora the truth about how every choice she made in her life, whether it was right or very wrong, has been with the hope of having her own daughter. “’Where do I go from here?’ is constantly what I’m asking myself, because I’m trying not to look back,” she says. “I’m always like, ‘This is what happened. Now, what do I have to live for?’”

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Transcript: Rep. Mike Turner on "Face the Nation with Margaret Brennan," Dec. 8, 2024The Fine Gael leader was asked about the controversy in the first question posed during the second and final TV leaders’ debate of Ireland’s General Election campaign. Mr Harris apologised over the weekend for his handling of the discussion with Charlotte Fallon while canvassing in Kanturk in Co Cork on Friday evening. The Taoiseach was accused of dismissing concerns that Ms Fallon raised about Government support for the disability sector during the exchange filmed by RTE in a supermarket. Mr Harris rang Ms Fallon on Saturday and said he unreservedly apologised for the way he treated her, however focus has since shifted to Fine Gael’s interactions with the national broadcaster about the social media video. At the outset of Tuesday’s TV debate, co-host Miriam O’Callaghan directly asked the Fine Gael leader whether a member of his party contacted RTE to ask for the clip to be taken down. “I have no knowledge of that whatsoever, because this clip was entirely appropriate,” said Mr Harris. “It was a very important moment on the campaign. “And RTE and indeed many media outlets have been with me throughout the campaign, covering many interactions that I’ve had with many, many people right across this country.” The Taoiseach said the approach by his team member was part of the “normal contact that happens between party politics and broadcasters on a daily basis”. Mr Harris’s partner-in-government in the last coalition, Fianna Fail leader Micheal Martin, said he was not aware of the approach to RTE by Fine Gael. “I didn’t realise this had happened,” he said. “I think Simon has given his explanation to it. I’m not sure it’s as normal or as usual. I just get on with it every day. But, again, I think, you know, I’m not au fait with the details behind all of this, or the background to it. “The video didn’t come down, and it was seen by many, many people. “And I think it illustrates that out there, there are a lot of people suffering in our society. “Notwithstanding the progress we’ve made as a country, a lot of people are facing a lot of individual challenges, and our job as public representatives and as leaders in travelling the country is to listen to people, hear their cases, to understand the challenges that they are going through in their lives. “And when we go about in election campaigns, we have to open up ourselves to criticism and to people calling us to account.” Sinn Fein leader Mary Lou McDonald had earlier in the day described reports of the Fine Gael approach to RTE as “chilling”. However, at the start of the debate, she was asked about a media-focused issue related to her own party, namely the controversial manifesto proposal for an independent expert review of RTE’s objectivity in its coverage of the war in Gaza and other international conflicts. Mr Harris previously branded the proposal a “dog whistle to conspiracy theorists” while Mr Martin said it was a “dangerous departure”. Ms McDonald defended the idea during the RTE Prime Time debate on Tuesday. “Politics and politicians should not try to influence editorial decisions or try and have clips taken down because they are inconvenient to them,” she said. “There has to be distance, there has to be objectivity. But I would say I am struck by the very defensive reaction from some to this (the review proposal). “The BBC, for example, a peer review looked at their coverage on migration. Politicians didn’t put their hands on it, and rightly so. “I think in a world where we have to rely on quality information, especially from the national broadcaster, which is in receipt of very substantial public funding, that has to be the gold standard of reliability. I think peer reviews like that are healthy.”

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