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FANS of The Great British Bake Off claimed one finalist was 'robbed' of the win. The Channel 4 series faces backlash from viewers as the hit show made history with its first ever Welsh winner . Paediatric nurse Georgie Grasso, 34, was awarded the coveted glass cake dish that was presented by Alison Hammond and Noel Fielding . This was despite never receiving one the highly sought after handshakes from Paul Hollywood , 58. She impressed Prue Leith , 84, with her incredible three tier lemon and elderflower hanging cake after she performed solidly in the technical. By comparison, fan favourite Great British Bake Off contestant Dylan Bachelet, 20, was having an off week. READ MORE ON BAKE OFF Throughout the show, he won acclaim for his innovative flavours and impeccable presentation. The retail assistant won the title of star baker twice, and was in the top two on three additional occasions. He failed to impress the judges with his scones, he came third in the technical and Paul Hollywood critiqued the proportions of each element of his showstopper. Viewers were left utterly devastated at the unfolding scenes as they took to social media in droves. Most read in News TV Writing on X - formerly known as Twitter - one fan stated: "I demand a recount. Dylan was robbed." A second user simply put: "Dylan. Robbed." "Dylan was robbed. Gutted," wrote a third viewer. As someone else noted: "So gutted for #Dylan he has been the winner all the way through the competition then stuffed it up in the final." Meanwhile, a fifth fan commented: "The story of Dylan in the final is a story ripped straight from ancient Greece . I've never watched a show about baking with such abject dread." And another added: "Watching Dylan lose the bake off after a great season was gutting." The Great British Bake Off is back for another series of the heartwarming Channel 4 show. Legendary judges Paul Hollywood and Prue Leith are back to give their expert opinion, while hosts Noel Fielding and Alison Hammond are on hand to lift the bakers spirits. Here are the amateur bakers all taking part in 2024. Andy, 44, car mechanic. Christiaan, 33, menswear designer. Dylan, 20, retail assistant. Georgie, 34, paediatric nurse. Gill, 53, senior category manager. Hazel, 71, former nail technician. Illiyin, 31, birth trauma specialist midwife. Jeff, 67, former university lecturer. John, 37, NHS directorate support manager. Mike, 29, farmer. Nelly, 44, palliative care assistant. Sumayah, 19, student. You can watch all the episodes of The Great British Bake Off 2024 on Channel 4 on demand.Valens Semiconductor Unveils Major Financial Strategy ShiftMALAGA, Spain (AP) — The last man to face — and beat — Rafael Nadal in professional tennis, 80th-ranked Botic van de Zandschulp , converted his 10th match point Friday to finally close out a 6-4, 6-7 (12), 6-3 victory over Daniel Altmaier and help the Netherlands reach its first Davis Cup final by sweeping Germany. Tallon Griekspoor, who is ranked 40th, sealed the 2-0 win for the Dutch in the best-of-three-match semifinal by hitting 25 aces and coming back to defeat Jan-Lennard Struff 6-7 (4), 7-5, 6-4. When it ended, appropriately, on an ace, Griekspoor shut his eyes, dropped to his knees and spread his arms wide. “We have been talking about this for two, three years,” Griekspoor said. “We believed in ourselves so much. We always felt like this was possible. To do it now feels unbelievable.” The other semifinal is Saturday, with No. 1-ranked Jannik Sinner and defending champion Italy taking on Australia . The championship will be decided Sunday. “We don’t have that top 5 player. We don’t that top 10 player. We don’t have that top 15 player,” Dutch captain Paul Harhuuis said. “But it’s a team effort. ... So proud of these guys.” In Friday's opener, van de Zandschulp was up a set and just a point away from leading 5-2 in the second when Altmaier began playing more aggressively and interacting more with the German fans, yelling and throwing uppercuts or raising his arms after key points. In the tiebreaker, Altmaier managed to save five match points before converting his own fourth set point to extend the contest. But van de Zandschulp — who upset four-time Grand Slam champion Carlos Alcaraz at the U.S. Open — quickly moved out front in the final set, even if he eventually needed five more match points in the last game before serving it out. “At some point, I didn’t know what to do any more on the match points,” van de Zandschulp said. “I had the toughest match of my life on Tuesday (against Nadal), so everything that comes next is maybe a little bit easier.” In the quarterfinals, van de Zandschulp outplayed Nadal for a 6-4, 6-4 result that marked the end of the 22-time Grand Slam champion’s career because the Netherlands went on to eliminate Spain 2-1. The 38-year-old Nadal announced last month that the Davis Cup would be his final event before retiring. Presumably because people purchased tickets ahead of time with plans to watch Nadal compete in the semifinals, there were hundreds of unoccupied blue or gray seats surrounding the indoor hard court at the Palacio de Deportes Jose Maria Martina Carpena in southern Spain on Friday. Now truly a neutral site, the place was not nearly as loud and rowdy as on Tuesday, although there were shouts of “Vamos, Rafa!” that drew laughter while van de Zandschulp played the 88th-ranked Altmaier. It took Griekspoor more than 75 minutes and nearly two full sets to figure out how to break No. 43 Struff and then did it twice in a row — to lead 6-5 in the second set, and then go up 1-0 in the third. That was plenty, because Griekspoor saved the only two break points he faced. The Netherlands hadn’t been to the semifinals since 2001. The Germans — whose best current player, two-time major finalist Alexander Zverev, is not on the team in Malaga — have won three Davis Cups, but not since 1993, when 1991 Wimbledon champion Michael Stich led them to the title. AP tennis: https://apnews.com/hub/tennis
The Conservatives stalled debate on an NDP opposition day motion in the House of Commons on Friday, a day after the New Democrats intervened in the Tories' own opposition day. The NDP was set to begin debate on a motion calling on the government to extend the upcoming GST break to what the party calls "essentials," including prepared foods at grocery stores, home heating and cellphone and internet bills. The motion also calls on the government to expand the proposed $250 "working Canadians rebate" to include fully retired seniors, people who rely on disability benefits and others who did not have employment income in 2023 — a key condition of the Liberal government's rebate. Conservative deputy leader Melissa Lantsman raised a point of privilege about a protest that happened earlier this week, saying three NDP members voiced support for protesters who blocked MPs from doing their work. Members of the Parliamentary Protective Service and Ottawa Police detain participants in an anti-war protest that occupied the lobby of the Confederation Building Tuesday morning. The building houses MPs' offices. (Raffy Boudjikanian/CBC) On Tuesday, about 100 protesters held a sit-in at the Confederation Building — which houses MPs' offices — to call for an arms embargo against Israel. Most of Friday's debate time was eaten up by Lantsman's privilege motion and a series of points of order raised by MPs who seemed bent on stalling NDP Leader Jagmeet Singh's opposition motion. It was just the latest episode of procedural hijinks among opposition parties, after the NDP had delayed debate on a Conservative non-confidence motion on Thursday by forcing a debate on abortion instead. The House adjourned for the week just before 2 p.m. on Friday. Deputy Speaker Chris d'Entremont said the debate on the privilege motion will resume on Monday. The votes on both the NDP GST motion and the Conservative non-confidence motion are scheduled to take place that day. The House of Commons has been in gridlock since late September, when the Conservatives began a filibuster on a separate privilege debate. That debate centres on the Liberals' refusal to provide unredacted documents about a now-defunct green technology fund to Parliament and the RCMP. The government has provided redacted copies of the documents, citing privacy concerns, and has said it would not be appropriate for Parliament to provide documents to the police. The RCMP says it is investigating the fund and that it likely could not use documents obtained through Parliament in that investigation. Still, the Tories say they will force the debate to continue until the Liberals hand over the documents or the NDP agrees to bring down the government. Because questions of privilege take precedence over nearly all other House business, the government has not been able to advance legislation. Parliament was heading toward an unprecedented situation of being unable to vote on a request from the government for more than $21 billion in spending. Earlier this week, House Speaker Greg Fergus intervened to pause the filibuster and schedule the four remaining days for opposition business and the vote on supplementary spending. Singh has said he will not vote in favour of the latest Conservative non-confidence motion. The NDP and Bloc Quebecois have voted down the Conservatives' two previous attempts to bring down the government this fall.LDI 2025 Announced for December 3-9 in Las Vegas NEW YORK, Dec. 19, 2024 (GLOBE NEWSWIRE) -- Questex’s Live Design International (LDI) 2024 delivered an unforgettable experience, bringing together over 13,000 global live event and entertainment design technology professionals and over 350 exhibitors. Packed with groundbreaking gear and technology, unparalleled education, and industry-defining moments, LDI 2024 proved why it remains the ultimate gathering for live entertainment and production technology. A Milestone Year for LDI 2024 Bursting with cutting-edge technology, unmatched education programs, and unforgettable networking opportunities, LDI 2024 reached new heights. The event featured the largest professional training program in its history, a 50% increase in LDInstituteTM classes, more than 125 LDInnovationTM Conference sessions, and a 10% larger exhibit floor showcasing over 350 exhibitors. “LDI 2024 was a vibrant celebration of the creativity, innovation, and community that power the live entertainment industry,” said Jessi Cybulski, Show Director, LDI. “With outstanding professional training, an electric show floor, and countless opportunities to connect, this year’s event exceeded expectations. We can’t wait to see what the industry will create in the coming year and showcase at LDI 2025.” LDI 2024 Highlights: A Buzzing Expo Hall : The expo floor was alive with energy for three days, featuring over 350 state-of-the-art exhibits where attendees experienced the latest gear, technologies, and trends shaping the future of live entertainment. For more information on exhibiting companies and products click here . Keynote Excellence: Visionary speakers like Thibaut Duverneix (Gentilhomme); Sharon Huizinga (Rock Lititz); Emily Malone (Disguise); and Craig Winslow (Experiential Designer) captivated audiences with their insights into the future of entertainment technology. Expanded Training Programs: This year’s educational offerings reached unprecedented levels, including 75 LDInstituteTM classes, 125 LDInnovationTM Conference sessions, and 200+ industry-leading speakers. Attendees participated in hands-on technology training, in-depth case studies, and behind-the-scenes tours, including expanded Rigging Training, the Stage Managers’ Academy, and the Architectural Lighting Design Focus. Unrivaled Networking Opportunities : From A La Carte Lunches and Brunches to exclusive After Dark parties hosted by Tao Group Hospitality, LDI 2024 fostered invaluable connections among industry professionals. Behind-the-Scenes Access: The Backstage Las Vegas Tours offered attendees rare insights into tech-savvy venues like Speigelworld’s DiscoShow culminating in a live performance of Cirque du Soleil’s Mystère, with its all-new lighting design. Fierce Battle of Busk Competition: An electrifying showdown over three days of intense busking training and competition, sponsored by industry leaders such as ACT Entertainment, AV Stumpfl/Pixera, ACME, Chauvet, Elation, ETC, hazebase, LINK, Pathway Connectivity Solutions, RCF, and StagePro, kept attendees on the edge of their seats. Inspiring the Next Generation: The Foster the Future program continued to champion emerging talent through initiatives like the Young Career Professionals Program, the Pat MacKay Diversity in Design Scholarships, and hands-on event production opportunities for aspiring industry professionals. What attendees and sponsors had to say about LDI 2024: “As far as the quality of programming and the quality of showroom floor, it's definitely some of the top memories I'll have when it goes to conferences and attending events,” said Michaela Ternasky-Holland, Creator, Immersive, Spatial, & Interactive Experiences (VR, AR, AI). “It's been really, really great to come back and experience LDI and just seeing the growth that has happened in just a short amount of time, both in the size of the overall event and then also the technology. If you're thinking about coming to LDI or getting into this industry, I would certainly recommend you taking advantage of this amazing opportunity that happens every year. Just great exposure to many of the manufacturers, all of the technology that you see on any of the events that are happening out there is here at the LDI conference. Even better are the people and the relationships that make all the live events in the industry happen. It's all about the people and the products, and it all happens here at LDI,” said Shane Smith, Sr. Director Technology, LMG, Inc. “It’s the perfect opportunity to see a showcase of the latest and greatest in tech, and also network and meet with the movers and shakers who are in this exciting field. As a first-time attendee when the Expo Floor opened, I was like a kid walking into a candy store. It was just incredible. The lights, the sounds, the noises, the people, the technology. Yeah, this is a great experience,” said Brian Crane, Founder, Crane Light & Design. “This is the conference that I go to because all of my friends are here. I was a lighting person back in the day. And this is the place that I come to see all the new technology, the new equipment. And now that I'm working more on the rigging side of things, I get a chance to come and talk about that this year,” said Kristi Ross-Clausen, Director of Education and Training, TheaterHealthandSafety.com. “LDI is a wonderful thing every year where all the vendors come together and you get an opportunity to see all of the new things out there. But, also, it's really a meeting of the minds where you get all the people who are actually creating this cutting-edge technology into one space. So, it's a great place to talk to people, pick up on what's coming up as far as ideas goes and what people have in the pipeline,” said Tyler DeLong, Managing Partner, DeLong Rigging Solutions. “LDI to me is the mecca for theater technology around the planet. If you want to broaden your horizons and know more about your craft, whatever that craft is, whether it's rigging, whether it's lighting, whatever it is, you come to LDI to see the latest products, to talk to the leaders in the industry and learn more about what it is that they do that makes them successful. It's honestly just a great place to get together with the OGs in the industry to swap stories, meet new people, encourage the young ones today to get into the business and help it grow, because this business is growing exponentially every day,” said Tracy Nunnally, Owner, Vertigo. “This is my favorite show. Not only do a lot of our customers come here, you have end users and production companies from some of the leading companies. So, we've met so many incredible contacts here. Many touring companies have come to visit our booth, and we're really excited for them to use INFiLED with some of the top performers in the country. Such amazing contacts, just a real incredible place, and really just a fun place to be. So, I definitely recommend everyone to be at LDI,” said Larry Lipsie, Senior Sales Manager, INFiLED. “It's been a great show. We've had a lot of really great interactions with tons of different people. Attendance has been really good this year,” said Will Komassa, President/CEO, Blizzard Lighting LLC. “It's been a fantastic show. We've seen all kinds of people here from students who are just starting out in their careers in the entertainment technology world, all the way up to the most seasoned professionals that we've ever seen at this show,” said Ryan Hindinger, Market Manager CT≤, ACT Entertainment. Looking Ahead to LDI 2025 LDI 2025 will take place December 3-9, 2025 at the West Hall in the Las Vegas Convention Center in Las Vegas, NV, with the conference starting December 3 and the expo floor open December 7-9. For sponsorship opportunities, contact Kelly Turner, Director of Sales, at kturner@questex.com . About Live Design International (LDI) Established in 1988, Live Design International (LDI) is built on a 36-year history as the essential trade show and conference for global live design professionals. Attendees come to LDI to see the latest gear and entertainment technology in action, covering audio, lighting, projection, video, staging, special effects, and XR. It is also a great opportunity to refresh knowledge and professional training, in addition to networking and finding inspiration from colleagues, manufacturers, and distributors at the vanguard of entertainment technology. For more information, visit http://www.ldishow.com/ . LDI will take place December 3-9, 2025, at the West Hall in the Las Vegas Convention Center in Las Vegas, NV. About Questex Questex helps people live better and longer . Questex brings people together in the markets that help people live better : hospitality and wellness; the industries that help people live longer : life science and healthcare; and the technologies that enable and fuel these new experiences . We live in the experience economy – connecting our ecosystem through live events, surrounded by data insights and digital communities. We deliver experience and real results. It happens here. Media Contact Charlene Soucy LDI csoucy@questex.com
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Traditionally, the holidays are for spending time with family and friends, perhaps with a varying degree of religious rituals or practices. There's also pressure not to miss certain family celebrations, but there will be times you can't make it – whether by choice or circumstance. So, if you're spending the holidays alone this year, you're actually not alone in wondering if it's OK to be alone. You hold the ticket to your happiness, even if you're spending the holidays (or any special day of the year) in a less conventional way—all by yourself. There's no correct formula for how to spend the holidays, experts say, and keeping that in mind is key when you're not going to be around your loved ones. Spending the holidays alone can feel lonely or empty, but it doesn't have to be that way. Loneliness is an issue during the winter holidays for many students and other clients, according to Diana Winston, director of UCLA Mindful , the mindfulness education center at UCLA Health. Not having people to spend the days with, "can compound any existing loneliness and worsen it during the holiday times," Winston said. New York psychologist Dr. Bryant Williams agreed, noting that being alone during the holidays "accentuates existing problems." Both experts suggest taking action to strengthen your mindset and fill your days with activities that you know nurture you. Go on a hike, take a walk in a park, visit the beach or engage in nature in a way that suits your lifestyle and location. Get out into "whatever nature you have available to you," Winston said, highlighting the importance of seizing opportunities to be outdoors. The benefits of simply being outside and surrounding yourself with nature are plenty, and why not rack up those benefits when you're spending the day or week alone? In the practice of forest bathing, one spends time in nature through activities like a walk or sitting and enjoying the environment, Dr. Leana Wen previously told CNN. "Forest therapy" can lower anxiety, improve mood and reduce blood pressure, studies show . You can simply take a walk, and make the most of that walk. A higher daily step count is linked to fewer depressive symptoms, according to a recent study in the journal JAMA Network Open. And it's not an impossible number—even 7,000 steps can lead to better mental health, said clinical psychologist Dr. Karmel Choi, who previously spoke to CNN. You don't have to miss out on all the fun just because you can't be there to celebrate in person. Williams recommended people take action to reach out to people with a phone or video call. Do something "similar to what people did during the pandemic, when people were so isolated," he said. "People, because they weren't spending time with each other in person, started spending a lot of time on Zoom." Social experiences are important to health, so carving out time for this can improve your well-being. More specifically, reach out to loved ones who make you feel good about yourself since positive social interactions are linked to better coping and lower stress, research shows. If your schedule and circumstances allow for catching up in-person, aim for a spontaneous coffee meetup with a friend or accept your colleague's invitation to join their festivities. None of the plans have to be grand, orchestrated celebrations. The point is to connect with someone at some point during the holidays if possible. Volunteering, such as at a children's hospital or at a nursing home, can be beneficial for those spending this season alone. You can also find opportunities to serve meals at a soup kitchen or food bank in your community. Some locations could use the help to hand out food at a holiday meal pick-up center. "There's all sorts of structured activities that people can engage in when they're spending time with other people, even strangers, and they're doing something thoughtful and nice for them," Williams said. That kind of an activity can impact one's brain in a positive way. "If someone takes action, they get outside of themselves, then they're thinking about other people," Williams said. "People generally feel better when that happens." You might be missing only your grandma's mac-and-cheese or wishing you were baking pies for many to enjoy. It's common for holidays to evoke images of people gathering around a shared meal. If you're alone, try to cook something special, order takeout or order something delicious at a restaurant, Winston said. If you're going to be out of town on a work trip, research the best nearby restaurants to your liking and splurge on a nice dinner. If you're choosing to be a homebody this year, be as lazy or as complex as you'd like with the meal—if it nurtures you. Rituals and fun family routines around the holidays are an important part of celebrating and maybe what you are missing most this time of year. "Can they perform some ritual that punctuates the day and makes it feel special in some way?" Williams said. Taking a hot bath, getting a massage or playing a sport can be nurturing to some people, Winston said. Light the menorah, hang up a stocking on your fireplace, or do the New Year's Eve countdown for yourself. You can observe the days however you'd like without disagreements with others, judgment or the pressure of expectations. Having a sense of accomplishment, such as by working on a home project, during this solitary time can also be one way to get through the holidays, Winston said. "People can be creative about their use of their time," she said. Seasonal chores like raking leaves or shoveling snow, decorating your house or decluttering your closets can also count as functional exercise without hitting the gym. Another more introspective activity is to take advantage of the solitude to plan for the new year or review the past year. "Especially for (the) new year, people love to reflect on the previous year," Williams said. "And doing that in an intentional, structured way and even outlining the ways they want the new year to be different or even citing specific goals for the new year." Spend the holiday creating new traditions, like creating a vision board or reviewing the highs and lows of your year in a journal. Winston suggests coupling actions with a strong mental approach—a mindfulness perspective— to help one with loneliness feelings. "Paying attention to our present moment experiences with openness, curiosity and a willingness to be with that experience" is mindfulness, according to Winston. "It's really about learning to live in the present moment, not lost in the past or the future." Understandably, the willpower to focus only on the now and block out the other noise can be challenging, and fully accepting that present reality is key. When things look and feel different and when one is in a transition period, clinical psychologist Dr. Adam Brown previously told CNN that there is no requirement to have the holidays look or feel the same as they had in the past. "Be compassionate with yourself and do the best that you can and know that this is a particular moment in the year," Winston said. "There's nothing wrong with you and you will get through it." It's also helpful to remember that not all those who are spending their holidays surrounded by people are having a good time. "We have a lot of input, demands and stress in general that is elevated during the holidays, so it is extra important to be attentive to your need for alone time," Sophie Lazarus, a clinical psychologist in the department of psychiatry and behavioral health at Ohio State University told CNN earlier this month. Due to some last-minute logistical challenges last month, I was unable to spend Thanksgiving with my family. Even though I knew I would be able to fly home the next day, I was still bummed to miss my family traditions. To make the best of the situation, I did as many of my favorite things as I could: I walked around my neighborhood, read news magazines and sat for hours in a bustling coffee shop to write. To cap it off, I went to a special Thanksgiving dinner by myself at a local restaurant. I missed time with my family, but I would say I still had an experts-approved day. I highly recommend turning your day alone into a gratifying one, and even if you're not going to be alone, try to carve out time for yourself in the midst of social obligations to help keep you grounded and serene.By Haripriya Suresh BENGALURU (Reuters) - India's Tech Mahindra is stepping up focus on its banking, financial services and insurance (BFSI) business in a bid to bridge the gap with larger peers which have historically made more revenue from the lucrative segment, its CEO said in an interview. Mohit Joshi, who took the helm of India's No.5 software services exporter in December 2023 after more than two decades at Infosys, wants to increase the share of BFSI in Tech Mahindra's revenue mix by up to 25% by March 2027, from about 16% currently. Some of Tech Mahindra's peers in the $254 billion Indian IT sector already make as much as a third of their revenue from this sector. "We still have a lot of room to catch up," said Joshi, who started out as a banker with ABN Amro and ANZ before joining Infosys. "I do expect that the relative share of BFSI revenue within TechM will increase, but...organically." Unlike its peers, Tech Mahindra has relied heavily on telecom clients to boost revenue. That will change as Joshi tries to take advantage of his own expertise and experience dealing with financial services firms to turn the company around. "BFSI is the single largest spender from a tech services perspective. It's very important for us to play aggressively in this space. Large banks typically spend over $10 billion a year in terms of technology," Joshi said. Tech Mahindra, which has lagged its peers in both revenue and profit, will focus on core banking, payments, asset and wealth management and custodian services, as well as insurance, he said. Joshi has already shored up its BFSI leadership. GENERATIVE AI Generative artificial intelligence is a friend and not a foe for the sector, according to Joshi. "GenAI is the best spokesperson for why we need more money to be spent on technology," he said, adding it is not the end of the road for software developers. "I do feel that the overall demand for developers is not going to reduce, because there is a lot more work to be done candidly than there are people just now." Joshi played down concerns about any potential hit to customer service roles at Tech Mahindra. "I'm very skeptical about whether we'll see a wholesale replacement of contact centers with GenAI because when it comes to critical issues, people prefer to speak with human beings." (Reporting by Haripriya Suresh; Editing by Dhanya Skariachan and Varun H K)
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Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.Dolby Laboratories SVP John Couling sells $4.57 million in stockCredit: Adobe Stock Deucravacitinib (Bristol Myers Squibb) was superior to placebo in achieving American College of Rheumatology 20 (ACR20) response in people with psoriatic arthritis (PsA) after 16 weeks of treatment, leading 2 pivotal phase 3 trials, POETYK PsA-1 (IM011-054) and POETYK PsA-2 (IM011-055), to achieve their primary endpoints. 1 "Psoriatic arthritis is a heterogenous disease that causes a range of different symptoms, including joint pain and swelling, as well as psoriatic skin lesions. Despite available therapies, rheumatologists continue to express a need for a safe and effective oral treatment," Roland Chen, MD, senior vice president and head, Immunology, Cardiovascular and Neuroscience development, Bristol Myers Squibb, said in a statement. 1 "These POETYK PsA-1 and POETYK PsA-2 findings demonstrate that oral Sotyktu has the potential to be the first TYK2 inhibitor for people living with psoriatic arthritis and reinforce the established efficacy and safety profile of Sotyktu. We are encouraged by the positive data across both Phase 3 trials and look forward to discussing the results with health authorities." Bristol Myers Squibb also announced that the 2 trials had met important secondary endpoints across PsA disease activity at Week 16, and the overall safety profile of deucravacitinib through 16 weeks of treatment was consistent with its established safety profile in a Phase 2 PsA clinical trial and Phase 3 trials in moderate-to-severe plaque psoriasis (PsO). Both trials were multicenter, randomized, double-blind, placebo-controlled trials that enrolled adults with active PsA. POETYK PsA-1 enrolled approximately 670 patients with biologic disease-modifying antirheumatic (bDMARD) drug-naïve active PsA. POETYK PsA-2 enrolled approximately 730 patients with active PsA who were bDMARD naïve or had previously received TNFα inhibitor treatment. Both trials were conducted over 52 weeks, with a placebo-controlled treatment period through Week 16, followed by a reallocation and continued active treatment period from Week 16 to Week 52. POETYK PsA-2 also included an apremilast safety reference arm. Patients that completed either study are potentially eligible to enroll in the open-label long-term extension (LTE) study. 1 Deucravacitinib is currently FDA approved under the name Sotyktu as an oral treatment for adults with moderate-to-severe plaque PsO. 2 Bristol Myers Squibb also recently announced data that demonstrate a consistent safety profile and durable clinical response with continuous deucravacitinib therapy through 3 years of use among people with PsO. 3 Among the 1519 individuals who were given at least a single administration of deucravacitinib, 513 maintained continuous treatment with the drug from the beginning of the parent trials and entered the LTE phase. Investigators found that exposure-adjusted incidence rates (EAIRs) per 100 person-years for adverse events (AEs), discontinuations due to treatment-related AEs, and deaths were all found to have either been lowered or remained consistent when comparing the 1-year and 3-year cumulative periods. 3 Specifically, from the 1-year point to the 3-year point, discontinuations were at 4.4 compared to 2.4, AEs had rates of 229.2 compared to 144.8, SAEs at 5.7 compared to 5.5, and deaths at 0.2 compared to 0.3. These adverse events (AEs) included COVID-19, nasopharyngitis, and upper respiratory tract infections, highlighting the varying rates of AE incidence across the cumulative periods. 3 Bristol Myers Squibb Announces Positive Topline Results from Two Pivotal Phase 3 Trials Evaluating Sotyktu (deucravacitinib) in Adults with Psoriatic Arthritis. News release. Bristol Myers Squibb. December 23, 2024. https://news.bms.com/news/details/2024/Bristol-Myers-Squibb-Announces-Positive-Topline-Results-from-Two-Pivotal-Phase-3-Trials-Evaluating-Sotyktu-deucravacitinib-in-Adults-with-Psoriatic-Arthritis/default.aspx U.S. Food and Drug Administration Approves SotyktuTM (deucravacitinib), Oral Treatment for Adults with Moderate-to-Severe Plaque Psoriasis. News release. Bristol Myers Squibb. September 9, 2022. https://news.bms.com/news/details/2022/U.S.-Food-and-Drug-Administration-Approves-Sotyktu-deucravacitinib-Oral-Treatment-for-Adults-with-Moderate-to-Severe-Plaque-Psoriasis/default.aspx Armstrong AW, Lebwohl M, Warren RB, et al. Safety and Efficacy of Deucravacitinib in Moderate to Severe Plaque Psoriasis For Up to 3 Years: An Open-Label Extension of Randomized Clinical Trials. JAMA Dermatol. Published online November 27, 2024. doi:10.1001/jamadermatol.2024.4688.
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EKF Brand Representative in Russia Electrical Solutions Recognized for Industry ContributionsIn 2008, Ankit tried again and secured an impressive 400th rank in the IIT entrance exam. He was admitted to IIT Delhi Published: November 27, 2024 5:20 AM IST By Edited by Ankit Prasad is a young entrepreneur from the small town of Chaibasa in Jharkhand. His father initially worked as a lab in-charge at Tata College in Chaibasa. He later secured a position at IIT Jamshedpur. From a young age, Ankit and his brother Rahul developed a strong interest in web designing. During their school years, they began exploring various websites and turned their passion into a small venture. Their craze for computers was further encouraged when their father gifted them a computer in 1995. By the age of six, Ankit had already started learning programming. Balancing Studies and Earnings Ankit ranked among the top three in his class 10th examinations. In 2005, while attending college, Ankit and Rahul started earning through web services. They designed websites for hotels, restaurants, and other businesses. Like many youngsters from small towns, Ankit dreamt of cracking the IIT entrance exams. In 2007, he appeared for the exam and secured a rank of over 5,000. Though eligible for admission to NIT Jamshedpur, he decided to aim higher. Journey to IIT In 2008, Ankit tried again and secured an impressive 400th rank in the IIT entrance exam. He was admitted to IIT Delhi, where he pursued Mathematics and Computer Programming. During his time at IIT Delhi, he was exposed to a variety of people that shaped his innovative mindset. Ankit recalls how witnessing the rise of companies like Zomato and Flipkart in Delhi’s budding startup ecosystem inspired him. The exposure pushed him to dream big and think innovatively. Left IIT Ankit shares that during his time at IIT Delhi, he worked with several companies and gained valuable experience. He then created a social networking platform called Touch Talent, but it didn’t achieve significant success. in 2012, Ankit left IIT to pursue his dream. In 2015, he co-founded Bobble AI with his brother Rahul. The app applies a user’s selfie to a database of emojis, stickers, and GIFs, among other graphics in order to make texting more expressive and visual. Success with Bobble AI Their company developed the “Bobble Indic Keyboard,” which supports 37 Indian languages and over 120 global languages. By 2023, Bobble AI had achieved a remarkable revenue of Rs 750 crore. In 2018, Ankit was included on the Forbes 30 under 30 list because of his remarkable achievement. He also appeared in Business World magazine’s list of the 40 under 40. For breaking news and live news updates, like us on or follow us on and . Read more on Latest on . TopicsUnrivaled, the new 3-on-3 women's basketball league launching this winter, signed LSU star guard Flau'jae Johnson to a name, image and likeness deal. Johnson is the second college player to ink an agreement with Unrivaled, following UConn's Paige Bueckers. They won't be participating in the upcoming inaugural season, but Johnson and Bueckers will have equity stakes in the league. Unrivaled dropped a video on social media Thursday showing Johnson -- who also has a burgeoning rap career -- performing a song while wearing a shirt that reads, "The Future is Unrivaled." The deal will see Johnson create additional promotional content for the league. Johnson, 21, was a freshman on the LSU team that won the 2023 national championship. Now in her junior year, Johnson is averaging career highs of 22.2 points, 6.0 rebounds and 3.3 assists per game through 10 games for the No. 5 Tigers (10-0). She ranks eighth in Division I in scoring. Johnson has career averages of 14.1 points, 5.8 rebounds and 2.3 assists per game in 82 career appearances (80 starts) for LSU. --Field Level Media