777 jili apk
El Salvador's president is triumphant after his bet on bitcoin comes trueChance of direct attack by Russia ‘remote’, says UK armed forces chiefUnlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. Recommended Videos For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.
Democrat Bob Casey concedes to Republican David McCormick in Pennsylvania Senate contest
Anthem Blue Cross Blue Shield reverses decision to put time limit on anesthesiaWhat happens when 'The Simpsons' join 'Monday Night Football'? Find out during Bengals-Cowboys
None
Ottawa customers turning to couriers to get holiday packages shipped as Canada Post strike continuesThe San Francisco 49ers suffered two key injuries to their offensive backfield during their 35-10 "Sunday Night Football" loss to the Buffalo Bills in Week 13. Early in the contest, starting running back Christian McCaffrey left the game after suffering a knee injury. He was replaced by his top backup, Jordan Mason . However, Mason suffered an ankle injury later in the game and had to exit as well. On Monday, 49ers coach Kyle Shanahan revealed that McCaffrey had suffered a PCL injury that would likely end his season, while Mason suffered a high-ankle sprain. Both running backs ended up on IR , further depleting a running back room that had already lost veteran Elijah Mitchell to a season-ending hamstring injury. Who do the 49ers have left in their running back room? Here's a look at the thin, inexperienced crew looking to lead the San Francisco backfield over the season's final five weeks. BILLS VS. 49ERS: Winners and losers from Buffalo's dominant 'Sunday Night Football' victory NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more. 49ers RB depth chart After McCaffrey and Mason's injuries, the 49ers have just two healthy running backs remaining in their organization. One is on the 53-man roster, and the other is on the practice squad. They are as follows: Guerendo, a fourth-round rookie out of Louisville, is expected to have a chance to operate as San Francisco's lead back with McCaffrey and Mason sidelined. Isaac Guerendo fantasy outlook Guerendo has been used sparingly but has racked up 246 yards and two touchdowns on 42 rushes, good for a 5.9 yards per carry average. Guerendo has often shown off his impressive speed (he ran the 40-yard dash in 4.33 seconds at the 2024 NFL Combine) when on the field. He tallied 19 yards and a touchdown on four carries against the Bills. He had a career-high 17 touches and 102 total yards when the 49ers beat the Dallas Cowboys 30-24 in Week 8, so it appears that the 6' 0'', 221-pound back is capable of handling a full workload. Taylor is more experienced than Guerendo, as he is in his fifth NFL season. He spent most of his career with the Green Bay Packers and has tallied 286 yards and a touchdown on 72 carries (good for a yards-per-carry average of 4). Taylor has just eight total touches and 37 yards in eight games for the 49ers this season. He will likely see more action after the injuries to the backs ahead of him. San Francisco will likely add another running back to its roster to ensure the team is three-deep at the position. Fullback Kyle Juszczyk and wide receiver Deebo Samuel could also see an uptick in carries as the team figures out the best way to replace McCaffrey and Mason.Bitcoin shot past $100,000 for the first time on Thursday, taking the limelight away from stock markets that wavered as investors tracked political crises in France and South Korea. Oil prices fell modestly despite a move by the OPEC cartel and its allies to extend their supply cuts amid concerns about oversupply. Wall Street's main stock indexes retreated from records, while Paris and Frankfurt forged higher despite political uncertainty in Paris. Bitcoin reached a high of $103,800.45 before dipping below the symbolically important level to $99.154 near 2200 GMT. The digital asset has now soared more than 50 percent since the election of Donald Trump, who has vowed to make the United States the "bitcoin and cryptocurrency capital of the world". "Bitcoin smashed through $100,000 as the Trump Trade powered on with force," noted Dan Coatsworth, investment analyst at AJ Bell. The historic level was broken after Trump picked crypto proponent Paul Atkins to take over as chair of the Securities and Exchange Commission, the markets regulator. Atkins is founder of risk consultancy firm Patomak Global Partners, whose clients include companies in the banking, trading and cryptocurrency industries. Atkins "is unlikely to be as anti-crypto as his predecessor Gary Gensler", said Kathleen Brooks, research director at XTB trading platform. "Thus, politics is driving bitcoin. We doubt that the rally will stop here," she added. Stock markets struggled for direction ahead of important US jobs figures on Friday. Aaron Clark, an equity portfolio manager at GW&K, said investors "are probably not willing to step in" ahead of Friday's November employment data. "We've seen record inflows into equities," said Clark, who thinks the market could be poised for additional gains later in December. Paris closed higher despite the historic no-confidence vote that ousted the government of French Prime Minister Michel Barnier. President Emmanuel Macron vowed to name a new prime minister in the coming days to prevent France from sliding deeper into political turmoil, rejecting growing pressure from the opposition to resign "The French political crisis failed to knock European indices off course," said Coatsworth, an analyst at AJ Bell. Frankfurt was also in the green but London was flat. Most Asian stock markets finished higher but Seoul closed in the red. South Korean President Yoon Suk Yeol clung to power Thursday, his party announcing they will oppose an impeachment motion after his short-lived imposition of martial law stunned the world. Sign up to get our free daily email of the biggest stories! "The silver lining we think is that the swift reversal of the martial law underscores the resilience of South Korea's institutions," said analysts at BMI, a unit of Fitch Solutions. "For now, we expect limited implications for the economy and financial markets as the Bank of Korea and the ministry of finance have responded swiftly by reassuring investors," they added. New York - Dow: DOWN 0.6 percent at 44,765.71 (close) New York - S&P 500: DOWN 0.2 percent at 6,075.11 (close) New York - Nasdaq: DOWN 0.2 percent at 19,700.26 (close) London - FTSE 100: UP 0.2 percent at 8,349.38 (close) Paris - CAC 40: UP 0.4 percent at 7,330.54 (close) Frankfurt - DAX: UP 0.6 percent at 20,358.80 (close) Tokyo - Nikkei 225: UP 0.3 percent at 39,395.60 (close) Hong Kong - Hang Seng Index: DOWN 0.9 percent at 19,560.44 (close) Shanghai - Composite: UP 0.1 percent at 3,368.86 (close) Euro/dollar: UP at $1.0591 from $1.0511 on Wednesday Pound/dollar: UP at $1.2760 from $1.2701 Dollar/yen: DOWN at 150.09 yen from 150.59 yen Euro/pound: UP at 82.97 from 82.75 pence Brent North Sea Crude: DOWN 0.3 percent at $72.09 per barrel West Texas Intermediate: DOWN 0.4 percent at $68.30 per barrel burs-jmb/arp
Cowboys G Zack Martin, CB Trevon Diggs out vs. CommandersISU makes changes as state lawmakers take aim at DEI programs
Police release new photos as they search for the gunman who killed UnitedHealthcare CEO NEW YORK (AP) — Two law enforcement officials say a masked gunman who stalked and killed the leader of one of the largest U.S. health insurance companies on a Manhattan sidewalk used ammunition emblazoned with the words “deny,” “defend” and “depose." The official were not authorized to publicly discuss details of the ongoing investigation and spoke Thursday to The Associated Press on condition of anonymity. Police also released photos of a person they say is wanted for questioning in the ambush the day before of UnitedHealthcare CEO Brian Thompson. The words on the ammunition may have been a reference to tactics insurance companies use to avoid paying claims. Elon Musk and Vivek Ramaswamy are bringing Trump's DOGE to Capitol Hill WASHINGTON (AP) — It’s DOGE time at the U.S. Capitol. Billionaire Elon Musk and fellow business titan Vivek Ramaswamy arrived on Capitol Hill for meetings with lawmakers. The two are heading up President-elect Donald Trump's Department of Government Efficiency, or DOGE, with its plans to “dismantle” the federal government. Trump tapped the duo to come up with ways for firing federal workers, cutting government programs and slashing federal regulations — all part of Trump's agenda for a second-term at the White House. House Speaker Mike Johnson said there's going to be “a lot of change” in Washington. Hegseth faces senators' concerns not only about his behavior but also his views on women in combat WASHINGTON (AP) — Pete Hegseth has spent the week on Capitol Hill trying to reassure Republican senators that he is fit to lead President-elect Donald Trump’s Department of Defense in the wake of high-profile allegations about excessive drinking and sexual assault. But senators in both parties have also expressed concern about another issue — Hegseth’s frequent comments that women should not serve in frontline military combat jobs. As he meets with senators for a fourth day Thursday, his professional views on women troops are coming under deeper scrutiny. Hegseth said this week that “we have amazing women who serve our military.” Pressed if they should serve in combat, Hegseth said they already do. Hamas official says Gaza ceasefire talks have resumed after weekslong hiatus ISTANBUL (AP) — A Hamas official says that after a weekslong hiatus international mediators have resumed negotiating with the militant group and Israel over a ceasefire in Gaza, and that he was hopeful a deal to end the 14-month war was within reach. Ceasefire negotiations were halted last month when Qatar suspended its talks with mediators from Egypt and the United States over frustration with a lack of progress between Israel and Hamas. But Bassem Naim, an official in Hamas’ political wing, said Thursday in an interview with The Associated Press that there has been a “reactivation” of efforts to end the fighting, release hostages from Gaza and free Palestinian prisoners in Israel. Why the rebel capture of Syria's Hama, a city with a dark history, matters BEIRUT (AP) — One of the darkest moments in the modern history of the Arab world happened more than four decades ago, when then-Syrian President Hafez Assad launched what came to be known as the Hama Massacre. The slaughter was named for the Syrian city where 10,000 to 40,000 people were killed or disappeared in a government attack that began on Feb. 2, 1982, and lasted for nearly a month. Hama was turned into ruins. The memory of the assault and the monthlong siege on the city remains visceral in Syrian and Arab minds. Now Islamist insurgents have captured the city in a moment many Syrians have awaited for over 40 years. France's Macron vows to stay in office till end of term, says he'll name a new prime minister soon PARIS (AP) — French President Emmanuel Macron has vowed to stay in office until the end of his term in 2027 and announced that he will name a new prime minister within days. In his address to the nation on Thursday, Macron came out fighting, laying blame at the door of his opponents on the far right for bringing down the government of Michel Barnier. He said they chose “not to do but to undo” and that they “chose disorder.” The president also said the far right and the far left had united in what he called “an anti-Republican front.” He said he’ll name a new prime minister within days but gave no hints who that might be. 7.0 earthquake off Northern California prompts brief tsunami warning SAN FRANCISCO (AP) — The National Weather Service has canceled its tsunami warning for the U.S. West Coast after there was a 7.0 magnitude earthquake. According to the U.S. Geological Survey on Thursday, at least 5.3 million people in California were under a tsunami warning after the earthquake struck. It was felt as far south as San Francisco, where residents felt a rolling motion for several seconds. It was followed by multiple smaller aftershocks. There were no immediate reports of major damage or injury. Yoon replaces the defense minister as South Korea's parliament moves to vote on their impeachments SEOUL, South Korea (AP) — South Korea’s president has replaced his defense minister as opposition parties moved to impeach both men over the stunning-but-brief imposition of martial law that brought armed troops into Seoul streets. Opposition parties are pushing for a vote on motion to impeach President Yoon Suk Yeol on Saturday evening. They hold 192 seats but need 200 votes for the motion to pass. Yoon’s office said he decided to replace Defense Minister Kim Yong Hyun with Choi Byung Hyuk, a retired general who is South Korea’s ambassador to Saudi Arabia. Kim earlier apologized and said he ordered troops to carry out duties related to martial law. The Foreign Ministry also worked to mitigate the backlash and concern over South Korea's democracy. The US government is closing a women's prison and other facilities after years of abuse and decay WASHINGTON (AP) — The Associated Press has learned that the federal Bureau of Prisons is permanently closing its “rape club” women’s prison in California and will idle six facilities in a sweeping realignment after years of abuse, decay and mismanagement. The agency informed employees and Congress on Thursday that it plans to shutter the Federal Correctional Institution in Dublin, California, and its deactivate minimum-security prison camps in Wisconsin, Minnesota, Colorado, Pennsylvania, West Virginia and Florida. Staff and inmates are being moved to other facilities. The closures come amid an AP investigation that has uncovered deep, previously unreported flaws within the Bureau of Prisons. From outsider to the Oval Office, bitcoin surges as a new administration embraces crypto NEW YORK (AP) — Bitcoin burst on the scene after trust had withered in the financial system and Washington’s ability to protect people from it. Now, it’s Washington’s embrace of bitcoin that’s sending it to records. Bitcoin briefly surged above $103,000 after President-elect Donald Trump said he will nominate Paul Atkins, who's seen as friendly to crypto, to be the Securities and Exchange Commission's next chair. The crypto industry, meanwhile, did its part to bring politicians friendly to digital currencies into Washington. It's a twist from bitcoin's early days, when it was lauded as a kind of electronic cash that wouldn’t be beholden to any government or financial institution.