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golden empire jili png Apple, the tech giant renowned for its meticulous product launches and polished software updates, appears to be facing challenges in its ambitious pursuit of artificial intelligence. Recent reports from Bloomberg indicate that a “larger-than-usual” number of features planned for iOS 19 have been pushed back to 2026, raising concerns about the pace of Apple Intelligence development. This delay follows earlier reports of postponements for key Apple Intelligence features, including a major Siri upgrade, initially slated for iOS 19. These setbacks raise critical questions about Apple’s AI strategy and its ability to compete in the rapidly evolving AI landscape. This isn’t the first time Apple has taken a cautious approach with its software releases. With iOS 18, the company opted for a staggered rollout of features, prioritizing stability and refinement over a rushed launch. While this strategy has its merits, the repeated delays, particularly in the crucial domain of AI, suggest a potential struggle to integrate advanced AI capabilities seamlessly into its ecosystem. Delays and the AI Race: Apple’s deliberate approach to AI development stands in stark contrast to the aggressive strategies of competitors like Google and Microsoft. While Google’s Gemini and OpenAI’s ChatGPT have made significant strides, Apple seems to be taking a more measured path, focusing on individual feature refinement. However, these delays raise concerns about whether Apple risks falling behind in the AI race. The iOS 19 Delay: A Closer Look: While Apple hasn’t officially disclosed the specific iOS 19 features facing delays, Bloomberg’s report suggests that the postponements extend beyond the Siri upgrade. This implies that various AI-powered functionalities, potentially including enhancements to Apple Intelligence across core apps, may be impacted. Impact on User Experience: The delay of iOS 19 features could disappoint users anticipating significant AI advancements in their Apple devices. Features like enhanced contextual awareness, personalized automation, and improved predictive capabilities might be pushed further down the roadmap. This could affect user productivity and the overall Apple ecosystem experience . Challenges and Opportunities: The delays highlight the challenges Apple faces in developing and integrating sophisticated AI features while maintaining its high standards for user experience and privacy. However, this also presents an opportunity for Apple to refine its AI strategy, potentially focusing on deeper integration and more unique applications of AI that differentiate its offerings from competitors. My Perspective: As a technology enthusiast and long-time Apple user, I’ve been closely following the development of Apple Intelligence. While I appreciate Apple’s commitment to quality and privacy, I believe a more accelerated approach to AI development is crucial. The delays, especially with core features like Siri, raise concerns about Apple’s ability to keep pace with the rapid advancements in the AI field. Looking Ahead: Apple’s success in the AI arena hinges on its ability to balance its cautious approach with the need to deliver innovative AI experiences promptly. It remains to be seen how the company addresses these challenges and whether it can leverage its strengths in hardware and software integration to carve a unique space in the AI landscape . The coming months will be crucial for Apple as it navigates the complexities of AI development and strives to meet user expectations in an increasingly AI-driven world. The delays in iOS 19 features underscore the complexities Apple faces in its AI journey. While the company’s cautious approach has its merits, a more accelerated development cycle is crucial to remain competitive in the rapidly evolving AI landscape. Apple needs to strike a balance between its commitment to quality and privacy and the need to deliver timely and innovative AI experiences to its users. The future of Apple Intelligence depends on its ability to navigate these challenges and leverage its strengths to carve a unique position in the AI-powered world.Founder and CEO of Advonics Services Nigeria Limited, Emmanuel Egboh, is one of the few patriotic Nigerian businessmen focused on helping to enthrone and entrench a safer country. Turning entrepreneurial excellence and acclaim into an art form is not the stuff of vacuous or unambitious individuals. It requires passion and perseverance, ingenuity and industry, as well as the uncanny ability to see goldmines where mere mortals see landmines. Though a self-effacing and silent force of nature, Emmanuel Egboh, founder and CEO of Advonics Services Nigeria Limited, a best-in-class security company offering a wide range of high-tech security products and services for the telecoms, maritime, aviation, transportation, and logistics industries, represents the best of Nigeria’s new breed of businessmen identifiable by their peerless grit and guts, crystal-clear vision, patriotism, and relentless pursuit of excellence against all odds, the accretion of which has seen them breaking the glass ceilings. Egboh’s business aptitude and leadership approach in the security sector are helping to push and challenge the bounds of entrepreneurship while garnering jaw-dropping successful results. Indeed, he would have been forgiven or overlooked by society if, like his contemporaries, he profited from the widespread insecurity in the nation by joining in fanning its embers. After all, fuel subsidy profiteers and enablers are still roaming the streets freely and enjoying their loot. However, Egboh’s patriotic instincts would not permit such. He took the road less travelled by opting to help his beloved nation to sanitise and stamp out insecurity through an ethical and humane approach that led to the recalibration of the corporate identity and objectives of Advonics Services Nigeria Limited, a company he founded in 2003 as a carrier for private sector services in specialised home automation. Under Egboh’s leadership, ASNL has grown from a peripheral player into a trusted name and partner in the security industry with a proven track record of delivering innovative and reliable solutions on a regional and global scale while offering a wide range of high-tech security products and services tailored to the telecoms, maritime, aviation, transportation, and logistics industries. He cites 2007 as the year the company’s clientele tripled in size. “Thanks to the purchase of hi-tech security and safety equipment,” he recalls with gratitude. Between 2009 and 2013, ASNL successfully partnered the Imo State Government in municipal transportation transformation and security support equipment for the Government House and the State House of Assembly. In 2018, the company signed a deal with the Federal Ministry of Transportation and Ministry of Aviation to secure the railway terminals across the federation and deploy its high-tech liquid explosive detection system at the airports and borders. A year later, it introduced the EI-LS1525 Liquid Security Inspection System to the Federal Airport Authority of Nigeria (FAAN), which adopted and launched it across Nigerian airports. This device can detect hazardous and explosive liquid gels in sealed containers at airports. The company has introduced other innovative security solutions to solving insecurity at airports, train stations, and borders. Egboh says the years between 2020 and 2024 were the period the company took a quantum leap towards attaining its growth trajectory with major footprints in the aviation and rail infrastructure. Egboh is now recognised as an entrepreneurial genius for adroitly positioning ASNL as the leader in the deployment of tomorrow’s technology in both the rail and air transportation systems, critical government infrastructure, and border security to protect the country and its citizens from major internal and external threats. No wonder some of ASNL’s clients include federal ministries and agencies notably Aviation, Transportation, FAAN, and even the Department of State Security. What more? Awards and applauses have continued to flood in from all over the world. For helping to tackle insecurity in the most populous black nation in the world, Egboh was the recipient of the 2023 African Leaders of Integrity Merit Award by African Integrity Magazine in Accra, Ghana. The president of African Integrity Magazine, Ambassador Onwordi Onichabor, disclosed that the international recognition of integrity is bestowed on citizens of all nations, who have proven themselves as an embodiment of integrity, honesty, transparency, and accountability, and distinguished themselves in business and notable contributions to society. Egboh was also the recipient of Africa’s Most Outstanding Maritime Security and Logistics Services CEO of the Year 2024 by the Board of African Leadership Review. The board states that it remains committed to showcasing the continent’s brightest talents and highlighting the impactful work being done to drive Africa forward. The African Leadership Review Awards aims to recognise the outstanding contributions and achievements of African leaders in various sectors on the continent. “We started this journey in 2003 and today the story is different. Going beyond boundaries has been our watchword and now, we are on a mission of endless possibilities,” he says in one of those moments he looked back in gratitude to the almighty.Musk's Controversial Endorsement Sparks German Political StormWe’re counting down our top 10 stories of the year as they were covered in the pages of the Herald-Zeitung: 6. Tragic crashes claim lives of NB youth By Erica Wilson | The Herald-Zeitung The New Braunfels community mourned the loss of two local youths this year who died in vehicle accidents. Layne Adams was an eighth-grader at Oak Run Middle School. He died in January after a utility task vehicle accident, and his death was felt across the New Braunfels community. “He was one of our eighth-grade athletes and one of the most popular kids in the class, from a great family — a wonderful family,” said New Braunfels ISD athletic director Jim Streety following the accident. Hundreds of parents and students gathered at Unicorn Stadium, dressed in Unicorn blue, to mourn the loss in a moment of public grief on Jan. 7. “That’s what New Braunfels is,” Streety said. “That’s what our school and our school district is. That’s part of who we are. There’s a lot of love throughout our community.” A few months later in April, a 16-year-old New Braunfels boy died in a crash near Garden Ridge in Comal County. The crash occurred on Farm to Market Road 3009, about half a mile south of the intersection with FM 1863, according to the Texas Department of Public Safety. A 31-year-old San Antonio man was driving a 2023 Isuzu box truck north on FM 3009 about half a mile south of FM 1863. The 16-year old New Braunfels boy was driving a 2010 Toyota Sienna minivan southbound on FM 3009. The truck lost control after going too fast on a wet road, according to a Texas Department of Public Safety investigation report. The truck was driving “at an unsafe speed for the road/weather conditions” on the wet two-way road, according to the crash report. The truck “lost control and slid into the southbound lane of FM 3009,” striking the minivan. The 16-year-old minivan driver was pronounced dead at the scene. The truck driver was treated at a hospital for serious injuries. 5. Growth sparks even more developments By Kaitlynn Hutchins | The Herald-Zeitung No. 5 on this year’s countdown is the plethora of neighborhood developments being built around Comal County. From groundbreaking on the Mayfair development off of I-35 in New Braunfels to approval of the 400-acre Canyon Ranch development in Spring Branch, the new communities and new developments being built kept popping up in the H-Z’s headlines. Growth in Veramendi has been underway for many years now, but this year, the Del Webb company broke ground on the active adult section of the development designed for homebuyers ages 55 and up. The Del Webb section will include amenities such as a fitness center, clubhouse and pool, as well as proximity to nearby medical complexes and other amenities throughout Veramendi. Del Webb is known for building active adult communities throughout the country, including the 4,750-acre Sun City Texas development in Georgetown. “Our vision for Del Webb Veramendi is to create more than just a place to live; it’s to cultivate a lifestyle that encourages wellness, connection, and enjoyment,” said Shawn Seaberg, division president at PulteGroup – San Antonio. “Whether you’re passionate about fitness, socializing, or simply enjoying nature, there’s something for everyone here. We offer more than a beautiful home; we offer a place to belong.” Down the road in an unincorporated portion of the county near Spring Branch, Comal County commissioners approved the first and second phases of the Canyon Ranch development. The development is situated on a plot of land totaling 400 acres, with the first phase offering 118 lots on 32 acres and the second phase offering 52 lots on 13 acres. Mayfair, a new community featuring homes, parks, a Canyon ISD middle and elementary school, a farmer’s market, retail space and more amenities, made several headlines this year. Paving of roads in the development has begun and the community held its inaugural Mayfest this year, a family-friendly event that included activities such as hot air balloon rides, a bier and wein garten and a petting zoo. “I think Mayfair is different than other communities, and we want to do things that are fun and we will have events throughout the year,” said Kristi Robinson, Southstar marketing and community relations director. “This will be our big festival that we’ll have annually, but we plan to have concerts, different activities, social clubs — everything.”

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Plenoptic Camera Market Size, Regional Analysis, and Forecast 2024-2031 11-23-2024 07:19 PM CET | IT, New Media & Software Press release from: SkyQuest Technology The Plenoptic Camera Market is a dynamic and rapidly growing sector, driven by technological advancements in hardware, software, and digital infrastructure. It covers a diverse range of services such as cloud computing, cybersecurity, data analytics, and artificial intelligence. The increasing need for digital transformation across industries is propelling market growth. Emerging technologies like 5G, blockchain, and IoT are further unlocking new opportunities. With continuous innovation, the IT sector is poised for significant expansion in the coming years, particularly in the areas of automation and remote work solutions. Download a detailed overview: https://www.skyquestt.com/sample-request/plenoptic-camera-market Market Size and Growth: Global Plenoptic Camera Market size was valued at USD 1.52 billion in 2022 and is poised to grow from USD 1.8 billion in 2023 to USD 6.99 billion by 2031, growing at a CAGR of 18.5% in the forecast period (2024-2031). The most valuable investment indicators are insights into key market trends, making it easier for potential participants to make informed decisions. The research seeks to identify numerous growth opportunities that readers can consider and capitalize on by utilizing all the relevant information. By closely analyzing critical factors that influence growth, such as pricing, production, profit margins, and value chain dynamics, future market expansion can be predicted with greater precision. Key Market Players: Canon Inc. Lytro Inc. Apple Inc. Samsung Electronics OTOY Inc. Lenovo Logitech Rebellion Photonics Inc. Sony Corporation Panasonic Corporation Raytrix GmbH Microsoft Pelican Imaging Corp. Razer Inc. 10Moon Xiaomi Region-wise Sales Analysis: This chapter presents market data by region, including revenue, sales, and market share breakdowns. It also offers forecasts for sales growth rates, pricing strategies, revenue, and other key metrics for each analyzed regional market. Regions covered include: North America: United States, Canada, Mexico Europe: Germany, France, UK, Russia, Italy Asia-Pacific: China, Japan, Korea, India, Southeast Asia South America: Brazil, Argentina, Colombia Middle East & Africa: Saudi Arabia, UAE, Egypt, Nigeria, South Africa Discover Key Trends, Speak with Our Experts @: https://www.skyquestt.com/speak-with-analyst/plenoptic-camera-market Segments covered in the Plenoptic Camera Market include: Product Cable Assemblies, Connectors, Free Space Optics, Fiber, And Waveguides, Silicon Photonics, PIC-Based Interconnects, And Optical Engines Application Telecommunication, Data Communication Plenoptic Camera Market Size and Scope The Plenoptic Camera market has shown significant growth in recent years, fueled by rising demand for power electronics across industries such as automotive, telecommunications, and renewable energy. This market is set to grow further as the global adoption of electric vehicles and renewable energy increases. Plenoptic Camera are highly valued for their superior thermal conductivity, electrical insulation, and mechanical strength, making them essential components in power modules and electronic devices. With ongoing technological and manufacturing advancements, the applications of Plenoptic Camera are expected to expand, encompassing a broader range of uses in the near future. For a Comprehensive Report on the Plenoptic Camera Market 2024, Visit @: https://www.skyquestt.com/report/plenoptic-camera-market Frequently Asked Questions: 1. What are the global trends in sales, production, consumption, imports, and exports across regions (North America, Europe, Asia-Pacific, South America, Middle East, and Africa)? 2. Who are the leading manufacturers dominating the global market? 3. What is their production capacity, sales, pricing, cost, and revenue structure? 4. What are the risks and opportunities in the market? About Us: SkyQuest is an IP-focused Research and Investment Bank and Technology Accelerator. We offer access to technologies, markets, and financing across sectors like Life Sciences, CleanTech, AgriTech, NanoTech, and Information & Communication Technology. We collaborate closely with innovators, entrepreneurs, companies, and investors to help them leverage external R&D sources and optimize the economic potential of their intellectual assets. Our expertise in innovation management and commercialization spans North America, Europe, ASEAN, and Asia Pacific. Contact: Mr. Jagraj Singh Skyquest Technology 1 Apache Way, Westford, Massachusetts 01886, USA (+1) 351-333-4748 Visit our website: Skyquest Technology This release was published on openPR.

CARLSBAD, Calif. , Dec. 19, 2024 /PRNewswire/ -- Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that the U.S. Food and Drug Administration (FDA) has approved TRYNGOLZATM (olezarsen) as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS), a rare, genetic form of severe hypertriglyceridemia (sHTG) that can lead to potentially life-threatening acute pancreatitis (AP). TRYNGOLZA is the first-ever FDA-approved treatment that significantly and substantially reduces triglyceride levels in adults with FCS and provides clinically meaningful reduction in AP events when used with an appropriate diet (≤20 grams of fat per day). TRYNGOLZA is self-administered via an auto-injector once monthly. Experience the full interactive Multichannel News Release here: https://www.multivu.com/ionis-pharmaceuticals/9295551-en-tryngolza-olezarsen-fda-approval "Today's FDA approval of TRYNGOLZA heralds the arrival of the first-ever FCS treatment in the U.S. – a transformational moment for patients and their families. For the first time, adults with FCS can now access a treatment that substantially reduces triglycerides and the risk of debilitating and potentially life-threatening acute pancreatitis," said Brett P. Monia , Ph.D., chief executive officer, Ionis. "We are proud of our long-standing partnership with the FCS community and are grateful to the patients, families and investigators who participated in our clinical studies, enabling Ionis to make this new treatment a reality. The FDA approval of TRYNGOLZA is also a pivotal moment for Ionis, representing our evolution into a fully integrated commercial-stage biotechnology company – a goal we set out to achieve five years ago. With our rich pipeline of potentially life-changing medicines, we expect TRYNGOLZA to be the first in a steady cadence of innovative medicines we will deliver independently to people living with serious diseases." The FDA approval was based on positive data from the global, multicenter, randomized, placebo-controlled, double-blind Phase 3 Balance clinical trial in adult patients with genetically identified FCS and fasting triglyceride levels ≥880 mg/dL. In the Balance study, TRYNGOLZA 80 mg demonstrated a statistically significant placebo-adjusted mean reduction in triglyceride levels of 42.5% from baseline to six months (p=0.0084). Reductions from baseline to 12 months were further improved, with TRYNGOLZA achieving a placebo-adjusted 57% mean reduction in triglycerides. TRYNGOLZA also demonstrated a substantial, clinically meaningful reduction in AP events over 12 months; one patient (5%) experienced one episode of AP in the TRYNGOLZA group compared with seven patients (30%) who experienced 11 total episodes of AP in the placebo group. TRYNGOLZA demonstrated a favorable safety profile. The most common adverse reactions (incidence >5% of TRYNGOLZA-treated patients and at a >3% higher frequency than placebo) were injection site reactions (19% and 9%, respectively), decreased platelet count (12% and 4%, respectively) and arthralgia (9% and 0%, respectively). Results from the Phase 3 Balance study were previously published in The New England Journal of Medicine (NEJM). "With no treatment options previously available, we were limited to relying only on extremely strict diet and lifestyle changes as the sole preventative treatment option," said Alan Brown , M.D., FNLA, FACC, FAHA, clinical professor of medicine, Rosalind Franklin University of Medicine and Science ; Balance trial investigator. "The FDA approval of TRYNGOLZA is an important moment for people living with FCS, their families and physicians who now, for the first time, have a treatment that significantly lowers triglycerides and decreases the risk of potentially life-threatening acute pancreatitis events, as an adjunct to a low-fat diet. I am excited to have a medicine I can prescribe to my patients that has been shown to change the course of their disease." FCS is a rare, genetic, potentially life-threatening form of sHTG that prevents the body from breaking down fats and severely impairs the body's ability to remove triglycerides from the bloodstream due to an impaired function of the enzyme lipoprotein lipase (LPL). While healthy levels for adults are below 150 mg/dL, people with FCS often have triglyceride levels of more than 880 mg/dL and often have a history of pancreatitis. Those living with FCS have a high risk of potentially fatal AP, which is a painful inflammation of the pancreas, and chronic health issues such as fatigue and severe, recurrent abdominal pain. People living with FCS can also experience psychological and financial stress, which can significantly impact their quality of life. In the U.S., FCS is estimated to impact up to approximately 3,000 people, the vast majority of whom remain undiagnosed. "As a rare and difficult to diagnose disease, FCS has a profound impact on the lives of patients and families. Many people living with FCS have experienced severe pain their whole lives – sometimes so intense they require lengthy hospitalization stays – and struggle through life with daily fatigue, nausea, brain fog and stomach pain," said Lindsey Sutton Bryan , co-founder and co-president, FCS Foundation. "Until now, our treatment options have been limited, relying on diet alone to try to manage triglyceride levels and keep acute pancreatitis attacks at bay. For the first time, adults with FCS have seen their hope for a treatment become a reality." TRYNGOLZA will be available in the U.S. before year end. Ionis is committed to helping people access the medicines they are prescribed and will offer a suite of services designed to meet the unique needs of the FCS community through Ionis Every StepTM. As part of Ionis Every Step , patients and healthcare providers will have access to services throughout the treatment journey provided by dedicated Patient Education Managers and Ionis Every Step Case Managers, including insurance and affordability support, as well as services and resources, such as disease and nutrition education. Visit TRYNGOLZA.com for more information. TRYNGOLZA was reviewed by the FDA under Priority Review and had previously been granted Fast Track designation for the treatment of FCS, Orphan Drug designation and Breakthrough Therapy designation. Olezarsen is undergoing review in the European Union and regulatory filings in other countries are planned. Olezarsen is currently being evaluated in three Phase 3 clinical trials – CORE, CORE2 and ESSENCE – for the treatment of sHTG. Olezarsen has not been reviewed or approved for the treatment of sHTG by regulatory authorities. Webcast Ionis will hold a webcast today at 6:45pm ET to discuss the FDA approval. Interested parties may access the webcast here . A webcast replay will be available for a limited time. About TRYNGOLZATM (olezarsen) TRYNGOLZATM (olezarsen) was approved by the U.S. Food and Drug Administration as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS). TRYNGOLZA is an RNA-targeted medicine designed to lower the body's production of apoC-III, a protein produced in the liver that is a key regulator of triglyceride metabolism. It is the only treatment currently indicated in the U.S. for FCS, a potentially life-threatening disease. For more information about TRYNGOLZA, visit TRYNGOLZA.com . IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS TRYNGOLZA is contraindicated in patients with a history of serious hypersensitivity to TRYNGOLZA or any of the excipients in TRYNGOLZA. Hypersensitivity reactions requiring medical treatment have occurred. WARNINGS AND PRECAUTIONS Hypersensitivity Reactions Hypersensitivity reactions (including symptoms of bronchospasm, diffuse erythema, facial swelling, urticaria, chills and myalgias) have been reported in patients treated with TRYNGOLZA. Advise patients on the signs and symptoms of hypersensitivity reactions and instruct patients to promptly seek medical attention and discontinue use of TRYNGOLZA if hypersensitivity reactions occur. ADVERSE REACTIONS The most common adverse reactions (incidence >5% of TRYNGOLZA-treated patients and >3% higher frequency than placebo) were injection site reactions, decreased platelet count and arthralgia. Please see full Prescribing Information for TRYNGOLZA. About Familial Chylomicronemia Syndrome (FCS) FCS is a rare, genetic disease characterized by extremely elevated triglyceride levels. It is caused by impaired function of the enzyme lipoprotein lipase (LPL). Because of limited LPL production or function, people with FCS cannot effectively break down chylomicrons, lipoprotein particles that are 90% triglycerides. FCS is estimated to impact up to approximately 3,000 people in the U.S. People living with FCS are at high risk of acute pancreatitis (AP) in addition to other chronic health issues such as fatigue and severe, recurrent abdominal pain. People living with FCS are sometimes unable to work, adding to the burden of disease. About the Balance Study Balance is a global, multicenter, randomized, double-blind, placebo-controlled Phase 3 study evaluating the efficacy and safety of olezarsen in patients with FCS at six and 12 months. The primary endpoint was the percent change from baseline in fasting triglyceride levels at six months compared to placebo. Secondary endpoints included percent changes in triglyceride levels at 12 months, percent changes in other lipid parameters and adjudicated acute pancreatitis event rates over the treatment period. Following treatment and the end-of-trial assessments, patients were eligible to enter an open-label extension study to continue receiving olezarsen once every four weeks. About Ionis Pharmaceuticals, Inc. For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis has discovered and developed six marketed medicines for serious diseases, including breakthrough medicines for neurologic and cardiovascular diseases. Ionis has a leading pipeline in neurology, cardiology and other areas of high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep understanding of disease biology and industry-leading technology propels our work, coupled with a passion and urgency to deliver life-changing advances for patients. To learn more about Ionis, visit Ionis.com and follow us on X (Twitter) , LinkedIn and Instagram . Ionis Forward-Looking Statements This press release includes forward-looking statements regarding Ionis' business and the therapeutic and commercial potential of TRYNGOLZA, Ionis' technologies and other products in development. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, including but not limited to those related to our commercial products and the medicines in our pipeline, and particularly those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. Except as required by law, we undertake no obligation to update any forward-looking statements for any reason. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended Dec. 31, 2023 , and most recent Form 10-Q, which are on file with the SEC. Copies of these and other documents are available at www.Ionis.com . Ionis Pharmaceuticals® and TRYNGOLZATM are trademarks of Ionis Pharmaceuticals, Inc. Ionis Investor Contact: D. Wade Walke , Ph.D. info@ionis.com 760-603-2331 Ionis Media Contact: Hayley Soffer media@ionis.com 760-603-4679 View original content: https://www.prnewswire.com/news-releases/tryngolza-olezarsen-approved-in-us-as-first-ever-treatment-for-adults-living-with-familial-chylomicronemia-syndrome-as-an-adjunct-to-diet-302336747.html SOURCE Ionis Pharmaceuticals, Inc.

ZAGREB, Croatia (AP) — Croatia’s incumbent President Zoran Milanovic has a sweeping lead in Sunday’s election and could win the five-year presidency in the first round, according to an exit poll released immediately after the voting. The poll by the Ipsos polling agency and released by the state HRT television showed Milanovic winning over 50% of the votes, while his main challenger Dragan Primorac, a candidate of the conservative HDZ ruling party trailed far behind with 19%. Milanovic thanked voters in a post on social networks. The first official results are yet to be published. Pre-election polls predicted that the two would face off in the second round on Jan. 12, as none of all 8 presidential election contenders were projected to get more than 50% of the vote. Left-leaning Milanovic is an outspoken critic of Western military support for Ukraine in its war against Russia. He is often compared to Donald Trump for his combative style of communication with political opponents. The most popular politician in Croatia, 58-year-old Milanović has served as prime minister in the past. Populist in style, he has been a fierce critic of current Prime Minister Andrej Plenković and continuous sparring between the two has lately marked Croatia’s political scene. Plenković, the prime minister, has sought to portray the vote as one about Croatia’s future in the EU and NATO. He has labeled Milanović “pro-Russian” and a threat to Croatia’s international standing. “The difference between him and Milanović is quite simple: Milanović is leading us East, Primorac is leading us West,” he said. Though the presidency is largely ceremonial in Croatia, an elected president holds political authority and acts as the supreme military commander. Milanović has criticized the NATO and European Union support for Ukraine and has often insisted that Croatia should not take sides. He has said Croatia should stay away from global disputes, though it is a member of both NATO and the EU. Milanović has also blocked Croatia’s participation in a NATO-led training mission for Ukraine, declaring that “no Croatian soldier will take part in somebody else’s war.” His main rival in the election, Primorac, has stated that “Croatia’s place is in the West, not the East.” His presidency bid, however, has been marred by a high-level corruption case that landed Croatia’s health minister in jail last month and featured prominently in pre-election debates. During the election campaign, Primorac has sought to portray himself as a unifier and Milanović as divisive. “Today is an extremely important day,” Primorac said after casting his ballot. "Croatia is going forward into the future. Croatia needs unity, Croatia needs its global positioning, and above all Croatia needs peaceful life.” Trailing a distant third in the pre-election polls is Marija Selak Raspudić, a conservative independent candidate. She has focused her election campaign on the economic troubles of ordinary citizens, corruption and issues such as population decline in the country of some 3.8 million. Sunday’s presidential election is Croatia’s third vote this year, following a parliamentary election in April and the European Parliament balloting in June.

PHILADELPHIA (AP) — Corey McKeithan scored 28 points as La Salle beat Temple 83-75 on Saturday night. McKeithan shot 10 of 19 from the field, including 3 for 6 from 3-point range, and went 5 for 5 from the line for the Explorers (6-2). Demetrius Lilley added 13 points while shooting 5 for 12, including 2 for 4 from beyond the arc while he also had six rebounds. Jahlil White shot 3 of 13 from the field and 5 of 5 from the free-throw line to finish with 11 points, while adding 12 rebounds. Quante Berry led the Owls (4-3) in scoring, finishing with 18 points, 15 rebounds and two blocks. Temple also got 15 points from Jamal Mashburn Jr.. William Settle had 13 points and seven rebounds. La Salle took the lead with 14:45 to go in the first half and did not relinquish it. The score was 42-33 at halftime, with McKeithan racking up 16 points. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Mumbai: Adani Enterprises ' chief financial officer Jugeshinder Robbie Singh on Saturday defended the group against the US authorities' bribery accusations, saying that they pertain to only one contract that accounts for roughly 10% of Adani Green Energy 's overall business. Assembly Election Results Live Updates Maharashtra Election Results Jharkhand Election Results Bypoll Election Results In a post on microblogging site X, Singh also said the Adani group has a portfolio of 11 public companies and "none of the issuers (i.e., companies in our portfolio or specific issuers that are subsidiaries of the public companies) are accused of any wrongdoing in the said legal filing." On Thursday, the US Department of Justice and the US Securities and Exchange Commission charged Adani Group chairman Gautam Adani , his nephew Sagar Adani and Adani Green Energy managing director and CEO Vineet Jain among others for allegedly bribing government officials with over $250 million to help Adani Green secure solar energy contracts from state power distribution companies through Solar Energy Corporation of India (SECI). It also linked project finance entity Adani Green Energy Ltd Restricted Group 2 (AGEL RG2), a subsidiary of Adani Green, to the allegations. Adani Green is the group's renewable energy arm. 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The SEC move comes as the company looks at operationalising more capacity at its Khavda project in Gujarat, where it is building a 30 GW solar project, claimed to be the world's largest renewable energy park. About 2.2 GW of the facility has been operationalised until September. Adani Green Energy currently has a renewable energy capacity of 11.2 GW and plans to take that up to 50 GW by 2030. The controversy revolves around an 8 GW of solar+manufacturing linked project won by Adani Green Energy wherein the company has signed the majority of power purchase agreements. "The assets are being built under multiple special purpose vehicles where we can see existing exposure of ₹5,200 crore by financial institutions , none by banks and ₹2,700 crore in foreign currency borrowings," Bernstein Research said in a report on Friday. Even in the worst case, if the power purchase agreement gets terminated, the land and solar assets are still there and can be sold off or used for another contract, it said. "Renewable assets are literally like bonds." On the back of the charges, Adani Green Energy cancelled plans to raise $600 million in US dollar-denominated bonds on Thursday. The bond had been priced but was pulled after US prosecutors charged Adani in the alleged bribery scheme. Assembly Election Results Live Updates Maharashtra Poll Results Highlights 2024 Jharkhand Poll Results Highlights 2024 (You can now subscribe to our Economic Times WhatsApp channel )None

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Hayleys Energynet partners Hengyang Ritar Power for greener energy futureBy DEE-ANN DURBIN and MANUEL VALDES, Associated Press SEATAC, Washington (AP) — Background music is no longer an afterthought at many airports, which are hiring local musicians and carefully curating playlists to help lighten travelers’ moods . London’s Heathrow Airport built a stage to showcase emerging British performers for the first time this summer. The program was so successful the airport hopes to bring it back in 2025. Nashville International Airport has five stages that host more than 800 performances per year, from country musicians to jazz combos. In the Dominican Republic , Punta Cana International Airport greets passengers with live merengue music. Tiffany Idiart and her two nieces were delighted to hear musicians during a recent layover at Seattle-Tacoma International Airport . “I like it. There’s a lot of people here and they can all hear it,” said Grace Idiart, 9. “If their flight got delayed or something like that, they could have had a hard day. And so the music could have made them feel better.” Airports are also carefully curating their recorded playlists. Detroit Metro Airport plays Motown hits in a tunnel connecting its terminals. Austin-Bergstrom International Airport in Texas has a playlist of local artists compiled by an area radio station. Singapore’s Changi Airport commissioned a special piano accompaniment for its giant digital waterfall. Music isn’t a new phenomenon in airport terminals. Brian Eno’s “Music for Airports,” an album released in 1978, helped define the ambient music genre. It’s minimalist and designed to calm. But Barry McPhillips, the head of international creative for Mood Media, which provides music for airports and other public spaces, said technology is enabling background music to be less generic and more tailored to specific places or times of day. Mood Media – formerly known as Muzak – develops playlists to appeal to business travelers or families depending on who’s in the airport at any given time. It might program calmer music in the security line but something more energizing in the duty-free store. “We see it as a soundscape,” McPhillips said. “We design for all of these moments.” There’s a science to Mood Music’s decisions on volume, tempo, even whether to play a song in a major key versus a minor one, he added. “How do we want to affect their mood at that moment?” McPhillips said. “It’s not just like, ‘Here’s a load of songs.’ It’s a load of songs for that 10-minute segment, and then we move to the next 10 minutes.” At the same time, many airports are going low-tech, hiring local musicians to serenade travelers and give them a sense of the place they’re passing through. Chicago’s O’Hare and Midway airports have more than 100 live performances each year. Phoenix’s Sky Harbor International Airport began a live music program five years ago and now has two stages featuring local artists. Tami Kuiken, the manager of airport music in Seattle, said the Seattle-Tacoma airport launched its live music program about a decade ago after a city commissioner heard live music at the airport in Austin, Texas . “The idea was like, ’Man, why doesn’t Seattle have music? We’re a music city too,” Kuiken said. At first, the airport created a playlist featuring emerging artists along with famous ones like Pearl Jam . Then it decided to try live musicians for a 12-week trial. It was so successful that the airport now features live musicians daily and is building new performance spaces. “People’s anxiety levels are very high when they’re traveling,” Kuiken said. “The feedback that we started getting was that once they got through the checkpoint and they were greeted with music, all of a sudden their anxiety and stress levels dropped.” Related Articles The programs also benefit musicians, who get paid to perform and gain wider exposure. When Colorado Springs Airport announced a live music program in March, more than 150 musicians applied. It now hosts two two-hour performances each week. David James, a singer and guitarist who plays at Seattle’s airport about once a week, said waking up in time for a daytime gig took some adjustment. But he’s gained new fans from all over the world. “I get really sweet responses from people all the time, saying, ‘That was so soothing to be able to just sit and listen to music in between flights,’” James said. “So it feels like it’s especially therapeutic for people.” Country stars like Blake Shelton and Keith Urban have come through Nashville’s airport and interacted with local musicians, said Stacey Nickens, the airport’s vice president of corporate communications and marketing. Shelton even gave one his guitar. Otto Stuparitz, a musicologist and lecturer at the University of Amsterdam who has studied airport music, said airports should think carefully about their selections. Music that’s meant to be actively listened to – like live music or catchy pop songs – can be very distracting in an already chaotic environment, he said. He has noticed some airports – especially in Europe — turning off piped melodies altogether. But McPhillips said big spaces like airports can feel cold and unwelcoming without background music. “A well-crafted audio strategy is one that people aren’t particularly cognizant of,” he said. “They just know they’re having a good time and that it’s appropriate.” Durbin reported from Detroit.

On a bitterly cold Tyneside night West Ham finally remembered how to fight back. Even better for their beleaguered manager, Julen Lopetegui, a team inspired by standout performances from Tomas Soucek and Jarrod Bowen exhibited the sort of ruthless precision strangely absent from Newcastle’s game. Expertly taken goals from Soucek and Aaron Wan-Bissaka reinforced Lopetegui’s fragile job security, lifting West Ham to 14th , three points behind Eddie Howe’s team, as Newcastle’s hopes of Champions League qualification sustained a dent. Before a potentially tenure-defining match, Lopetegui took time to revisit the bronze statue of Sir Bobby Robson that stands just outside St James’ Park. During his days as a goalkeeper, West Ham’s manager played under Robson at Barcelona and learned a lot from him. Three decades on and with his team three points clear of the relegation zone at kick-off, Lopetegui desperately needed to coax the sort of performance Robson would have treasured from his West Ham players here. Although the east London club rarely change managers mid-season there were strong suggestions that the former Spain coach’s future hinged on his team’s performance on Tyneside and then at home against Arsenal on Saturday. Lopetegui knew that, with the former Borussia Dortmund coach Edin Terzic among those reportedly waiting in the wings, a heavy defeat could ruin his hopes of surviving until at least the weekend but, for once, the manager was not the only one in the firing line. Tim Steidten, West Ham’s technical director, is primarily responsible for the summer’s £100m-plus spending splurge and now finds himself under forensic scrutiny. Undeterred by all this off-field politicking, Soucek revelled in placing Howe’s defence under an unflattering microscope as, completely unmarked, he headed Lopetegui’s side into a 10th-minute lead following Emerson’s fine corner. With Lloyd Kelly suffering an alarming concentration lapse, Newcastle suddenly felt the suspended Dan Burn’s absence. They had been on top, with Alexander Isak having an early goal disallowed for offside but, despite subsequently spurning a series of half chances, Howe’s players were frustrated by Lopetegui’s five-man midfield. With the tension rising, West Ham’s manager received a yellow card for dissent after his lively left winger, Crysencio Summerville, was contentiously adjudged to have fouled Sean Longstaff. Given it was the Spaniard’s third booking of the season, he must now watch the Arsenal game from the stands while serving a one-game touchline ban. Howe’s decision to start Joelinton on the right rather than the left wing did not work well. The idea was presumably to offer Anthony Gordon the freedom of his preferred left flank but the England winger let himself down when he shot straight at Lukasz Fabianski, allowing the goalkeeper to save smartly with a leg, following Jean-Clair Todibo’s defensive error. The second period began with a relocation for Joelinton to midfield as Howe introduced Harvey Barnes wide on the left. Sign up to Football Daily Kick off your evenings with the Guardian's take on the world of football after newsletter promotion Barnes impressed but, unfortunately for Howe, his presence served to persuade Soucek and Bowen to redouble their efforts. While Soucek strained every sinew to hold his midfield together, Bowen showed off quick feet and an even faster brain down the right. Bowen played a key role in West Ham doubling their advantage after Lucas Paquetá pinched possession from Bruno Guimarães and played in the England forward. All that remained was for a player much admired by Howe to set up Aaron Wan-Bissaka on the underlap, leaving the right-back to take a touch before evading Nick Pope’s reach courtesy of a shot that brushed a post en route to the back of the net. It was only the third goal of Wan-Bissaka’s career. It proved the signal for Callum Wilson to step off the home bench for his first appearance of another injury-blighted season. He had scored 12 goals in 14 previous appearances against West Ham and quickly saw a penalty appeal rejected, but this was Lopetegui’s night and even Wilson could not spoil it.Teenage student philanthropist spreads Christmas cheer at Ocho Rios drop-in centreCreative Global Technology Holdings Limited Announces Pricing of Its Initial Public OfferingCarlsquare Advises Boomi on Acquisition of Data Integration Provider Rivery

The UCLA women’s basketball team is ranked No. 1 in the Associated Press women’s basketball poll for the first time in program history. The Bruins beat defending national champion South Carolina , the previous top team in the polls, on Sunday afternoon to rise from the No. 5 spot. The Gamecocks are now No. 4. UCLA is out to a 5-0 start this season and took down South Carolina 77-62 in a sold-out Pauley Pavilion. The accomplishment marked the first time in program history that the Bruins beat a No. 1 team. It’s the first time South Carolina lost a game in 602 days after a 43-game winning streak and it was the largest loss for South Carolina since March 2019 (15 points). “This means a lot because of the respect we have (for South Carolina),” UCLA head coach Cori Close said after the game. “That being said, we expected to win.” Bruins center Lauren Betts made the Big Ten Basketball Weekly Honor Roll after recording a double-double of 11 points and 14 rebounds in Sunday’s game. Londynn Jones led UCLA with 15 points and went a perfect 5-for-5 on 3-pointers. UCLA next heads to Honolulu for the Rainbow Wahine Showdown, which begins on Friday against UT Martin. Big Ten Conference play begins on Dec. 8 at Washington.What do Elon Musk and Vivek Ramaswamy plan to do with DOGE?

If you need a screen to go with the upgrade that you made with desktop computer deals , and you’re willing to spend for a top-of-the-line display, then you may want to set your sights on the LG 40WP95C-W UltraWide curved 5K monitor. From its original price of $1,800, you can get it for $1,240 from Walmart for huge savings of $560, or for $1,275 from Amazon for a $525 discount. You should complete your purchase quickly if you’re interested though, as there’s no telling when the offers for this monitor will expire. Why you should buy the LG 40WP95C-W UltraWide curved 5K monitor 5K monitors are highly recommended for serious creative professionals, such as graphic designers and filmmakers, for their extremely sharp details and precise colors, and the LG 40WP95C-W UltraWide curved 5K monitor is an excellent choice. We’ve tagged it as the best ultrawide 5K monitor in our roundup of the best 5K monitors , with its huge 40-inch curved screen featuring 5120 x 2160 resolution, 98% coverage of the DCI-P3 spectrum, and support for HDR10 providing striking visuals that you won’t enjoy from most of the other options in the market. The LG 40WP95C-W UltraWide curved 5K monitor works with Thunderbolt 4 for faster bandwidth, alongside a DisplayPort, two HDMI ports, a 3.5mm audio jack, and two USB 3.0 Type-A ports. You can use it for gaming as it’s equipped with AMD’s FreeSync technology that eliminates screen tearing and stuttering, and it also comes with built-in 10W speakers if you prefer not to use headphones or external speakers. The LG 40WP95C-W UltraWide curved 5K monitor also has a low blue light filter mode and auto-brightness with ambient light sensor, to keep your eyes comfortable while you look at its screen. While some monitor deals offer affordable screens at even lower prices, you can also enjoy huge savings on premium models like the LG 40WP95C-W UltraWide curved 5K monitor. Originally sold for $1,800, Walmart is offering a $560 discount that brings it down to $1,240, but it’s also available from Amazon for $1,275 for $525 in savings. No matter where you decide to buy the LG 40WP95C-W UltraWide curved 5K monitor, you need to act fast because these bargains may end at any moment, and once they’re gone, we’re not sure when you’ll get another chance at them.Guebert: Just how expensive is U.S. food?

Arclin unveils striking new brand that stands out in the material science industry with exacting precision and a bold new lookMALAGA, Spain (AP) — No. 1-ranked Jannik Sinner won matches in singles and doubles to lead defending champion Italy to a 2-1 comeback victory over Argentina on Thursday, earning a return trip to the Davis Cup semifinals. “I’m here trying to do the best I can in the singles,” Sinner said. “If they put me on the court in doubles, I’ll also try my best.” On Saturday, Italy will face Australia in a rematch of last year's final, but this time it will only be for a chance to play for the championship. Australia eliminated the U.S. 2-1 earlier Thursday to reach the final four at the team competition for the third consecutive year. The other semifinal, to be contested Friday, is the Netherlands against Germany. The Dutch got past Rafael Nadal and Spain in the quarterfinals earlier in the week, sending the 22-time Grand Slam champion into retirement. Italy fell behind 1-0 in the quarterfinals when Argentina’s Francisco Cerúndolo defeated Lorenzo Musetti 6-4, 6-1 on an indoor hard court at the Palacio de Deportes Jose Maria Martina Carpena in southern Spain. But then in stepped Sinner, whose season already includes two Grand Slam trophies — at the Australian Open and U.S. Open — plus the title at the ATP Finals last weekend in Turin, Italy. First he overwhelmed Sebastián Báez 6-2, 6-1. Then Sinner teamed with 2021 Wimbledon runner-up Matteo Berrettini in the deciding doubles match to win 6-4, 7-5 against Andres Molteni and Maximo Gonzalez. “He carried me today,” Sinner said about Berrettini. After arriving late to Malaga from Turin, Sinner did not get a chance to practice on the Davis Cup competition court before taking on Báez and stretching his streak to 22 sets won in a row. “In three minutes, he was perfectly comfortable on court,” Italy captain Filippo Volandri said. “He’s a special one.” Volandri swapped out his original doubles team, Simone Bolelli and Andrea Vavassori, for Sinner and Berrettini, and the change paid dividends. Australia, the Davis Cup runner-up the last two years, advanced when Matt Ebden and Jordan Thompson beat the surprise, last-minute American pairing of Ben Shelton and Tommy Paul 6-4, 6-4 in that quarterfinal's deciding doubles match. The Shelton-Paul substitution for Paris Olympics silver medalists Austin Krajicek and Rajeev Ram was announced about 15 minutes before the doubles match began. Ebden and John Peers beat Krajicek and Ram in the Summer Games final in August. The Australians broke once in each set of the doubles. In the second, they stole one of Shelton’s service games on the fourth break opportunity when Ebden’s overhead smash made it 5-4. Thompson then served out the victory, closing it with a service winner before chest-bumping Ebden. The 21st-ranked Shelton made his Davis Cup debut earlier Thursday in singles against 77th-ranked Thanasi Kokkinakis, who emerged from a tight-as-can-be tiebreaker by saving four match points and eventually converting his seventh to win 6-1, 4-6, 7-6 (14). No. 4 Taylor Fritz , the U.S. Open runner-up, then pulled the Americans even with a far more straightforward victory over No. 9 Alex de Minaur , 6-3, 6-4. When their match finally ended, on a backhand by Shelton that landed long, Kokkinakis dropped onto his back and pounded his chest. After he rose, he threw a ball into the stands, then walked over to Australia’s sideline, spiked his racket and yelled, before hugging captain Lleyton Hewitt. “I don’t know if I’ve been that pumped up in my life. I wanted that for my team,” said Kokkinakis, who won the 2022 Australian Open men’s doubles title with Nick Kyrgios. “It could have gone either way, but I kept my nerve.” AP tennis: https://apnews.com/hub/tennisNo ex-president had a more prolific and diverse publishing career than Jimmy Carter. His more than two dozen books included nonfiction, poetry, fiction, religious meditations and a children’s story. His memoir “An Hour Before Daylight” was a Pulitzer Prize finalist in 2002, while his 2006 best-seller “Palestine: Peace Not Apartheid” stirred a fierce debate by likening Israel’s policies in the West Bank to the brutal South African system of racial segregation. > Philadelphia news 24/7: Watch NBC10 free wherever you are And just before his 100th birthday, the Dayton Literary Peace Prize Foundation honored him with a lifetime achievement award for how he wielded "the power of the written word to foster peace, social justice, and global understanding.” In one recent work, “A Full Life,” Carter observed that he “enjoyed writing” and that his books “provided a much-needed source of income.” But some projects were easier than others. “Everything to Gain,” a 1987 collaboration with his wife, Rosalynn, turned into the “worst threat we ever experienced in our marriage,” an intractable standoff for the facilitator of the Camp David accords and winner of the Nobel Peace Prize. According to Carter, Rosalynn was a meticulous author who considered “the resulting sentences as though they have come down from Mount Sinai, carved into stone.” Their memories differed on various events and they fell into “constant arguments.” They were ready to abandon the book and return the advance, until their editor persuaded them to simply divide any disputed passages between them. “In the book, each of these paragraphs is identified by a ‘J’ or an ‘R,’ and our marriage survived,” he wrote. Here is a partial list of books by Carter: “Keeping Faith: Memoirs of a President” “The Blood of Abraham: Insights into the Middle East” (With Rosalynn Carter) “Everything to Gain: Making the Most of the Rest of Your Life” “An Outdoor Journal: Adventures and Reflections” “Turning Point: A Candidate, a State, and a Nation Come of Age” “Always a Reckoning, and Other Poems” (With daughter Amy Carter) “The Little Baby Snoogle-Fleejer” “Living Faith” “The Virtues of Aging” “An Hour Before Daylight: Memories of a Rural Boyhood” “Christmas in Plains: Memories” “The Hornet’s Nest: A Novel of the Revolutionary War” “Our Endangered Values: America’s Moral Crisis” “Faith & Freedom: The Christian Challenge for the World” “Palestine: Peace Not Apartheid” “A Remarkable Mother” “Beyond the White House” “We Can Have Peace in the Holy Land: A Plan That Will Work” “White House Diary” “NIV Lessons from Life Bible: Personal Reflections with Jimmy Carter” “A Call to Action: Women, Religion, Violence, and Power” “A Full Life: Reflections at Ninety”