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On Wednesday, Atea Pharmaceuticals, Inc. AVIR released Phase 2 study data from the regimen of bemnifosbuvir and ruzasvir for the hepatitis C virus infection that causes liver swelling and can lead to serious liver damage . The study met its primary endpoints of safety and sustained virologic response at 12 weeks post-treatment (SVR12). Primary endpoint results demonstrated a 98% (208/213) SVR12 rate in the per-protocol treatment adherent patient population after eight weeks of treatment with a regimen of bemnifosbuvir and ruzasvir. Also Read: Atea Pharmaceuticals’ COVID-19 Treatment Flunks In Late-Stage Study, Blames’ Constantly Evolving’ Virus The efficacy evaluable patient population, which included 17% treatment non-adherent patients, achieved a 95% (242/256) SVR12 rate demonstrating the potency and forgiveness of the regimen. In June, Atea Pharmaceuticals shared new data from the lead-in cohort (n=60) of its ongoing Phase 2 combination study of bemnifosbuvir and ruzasvir for hepatitis C virus . The regimen was generally safe and well-tolerated, with no drug-related serious adverse events or treatment discontinuations. Full data for the Phase 2 study will be presented at a scientific meeting during the first half of 2025. In the Phase 2 study, 99% (178/179) of treatment-adherent patients who were non-cirrhotic and infected with genotypes 1-4 achieved SVR12, demonstrating robust pan-genotypic potency and supporting an eight-week treatment in the Phase 3 program. Treatment adherent patients with cirrhosis achieved a 88% (30/34) SVR12 rate. Viral kinetics were slower in these cirrhotic patients. However, all patients achieved 100% end-of-treatment response. To maximize efficacy, the Phase 3 program will extend treatment duration to 12 weeks in patients with cirrhosis. Atea is preparing for the Phase 3 program, which is expected to follow an End of Phase 2 meeting with the FDA anticipated for early 2025. The Phase 3 program is expected to use a fixed-dose combination tablet, reducing the daily pill count from four to two tablets and enhancing patient convenience, with no food effect. Price Action: AVIR stock is down 9.63% at $3.15 at the last check on Wednesday. Read Next: Southland Holdings Lands $60M Wastewater Deal: Details © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.F1 Don't miss out on the headlines from F1. Followed categories will be added to My News. Daniel Ricciardo and Ash Barty have lost their jobs as Optus ambassadors. The telco giant quietly made the move this year after using the two widely-adored athletes as the face of the company during its recent turbulence. It appears even using two of the country’s most popular figures hasn’t been enough to cover for the fundamental issues that have plagued the telecommunications organisation. Watch every ball of Australia v India LIVE & ad-break free during play in 4K on Kayo | New to Kayo? Get your first month for just $1. Limited time offer. Ricciardo has been particularly synonymous with the brand after taking up a marketing position as Optus’ Chief of Optimism . The role included fronting several campaigns for the brand and featuring in viral stunts, including last year’s gimmick of the Formula 1 star going undercover as a storefront Optus employee. Ricciardo and Optus have worked together for four years, but the partnership will not be progressing, as exposed in changes to the former Red Bull driver’s LinkedIn profile which no longer mentions his ties with the company. Barty was also on the Optus payroll as the so-called Chief of Inspiration for the past two years. Ash Barty and Daniel Ricciardo. MORE: 8 things you didn’t know you could be fired for Their separation comes after Optus’ former chief executive Kelly Bayer Rosmarin was replaced by Stephen Rue in September. Optus confirmed the parting of ways with a brief message first issued to The Australian Financial Review . “The decision was taken as we looked to rebuild customer trust and focus on the fundamentals that we know are important to them – a resilient network, great value products and services, and simple, efficient customer service,” an Optus spokesperson said. Ricciardo is heading into the unknown in 2025. Having been cut by Red Bull’s junior team VCARB earlier this year, the 35-year-old has been linked with many new jobs that will keep him on the track. Right now he is without a seat for next year and is coming off one of the hardest years of his career where he was out-performed by his former teammate Yuki Tsunoda and replaced by Kiwi Liam Lawson. It’s why The Australian Financial Review’s Myriam Robin described Optus’ move as a “one-two kick in the guts for Daniel”. It emerged this week the axed F1 driver has been enjoying the unemployed life but still has plenty of options on the table. F1’s loss could be another category’s gain with the Aussie’s marketability and global recognition making him a prime target for the right team. While some have suggested the veteran could be a target for the new Cadillac team set to join the F1 grid in 2026 due to Ricciardo’s popularity in the US, his future has still not been publicly decided. Daniel Ricciardo poses for a photo with Ashleigh Barty at the Aussie Grand Prix Photo by Mark Thompson/Getty Images. MORE: Can I be fired for that? Which makes the latest rumblings out of Toyota all the more intriguing. Toyota are not on the F1 grid as a stand-alone team but have been in the past. Toyota Gazoo Racing was announced as a technical partner for the Haas F1 Team as of October and will provide design, technical and manufacturing services. However, Toyota has strong motorsport roots around the world, featuring in NASCAR and, as of 2026, will join Australia’s Supercars Championship with its GR Supra. Race.news reported last week that the company was prepared to make a “whatever it takes” bid to lure Ricciardo out of retirement. Believed to potentially be a $10m offer, similar to what he was reportedly earning at VCARB this season, it’s been described as a “blank cheque operation”. Barty, meanwhile, is sadly loving her life in retirement. The three-time grand slam champion retired in the prime of her career aged 25 and is loving life as a mum. The Aussie tennis champion and husband Garry Kissick, welcomed their first child, Hayden, in July 2023. Australia would dearly love to see both of them back in action. More Coverage Australia’s hottest WAG drops huge news Entire nation humiliated as Aussie quits Tyson Otto Originally published as Ash Barty, Daniel Ricciardo lose jobs as social update exposes truth Join the conversation Add your comment to this story To join the conversation, please log in. Don't have an account? Register Join the conversation, you are commenting as Logout More related stories F1 Lawyer erupts as Schumacher trial explodes The bombshell court case into a Michael Schumacher blackmail plot has exploded in court with a lawyer blowing up over one interview. Read more F1 Oscar Piastri celebrates huge personal news Oscar Piastri has every reason to smile after some huge news dropped at the end of the Aussie’s successful F1 season with McLaren. Read more
Fundador da Xsolla, Shurick Agapitov, lança Once Upon Tomorrow Fortnite Island: uma experiência imersiva inovadora que dá vida ao universo do livroIt’s the season of celebrations, indulgence, and gift-giving! If you have a friend, family member, or co-worker who’s notoriously hard to shop for, consider the gift of spirits. Whether they’re a craft cocktail enthusiast or a whiskey connoisseur, we’ve got recommendations to suit everyone on your list. And while you’re at it, don’t forget to treat yourself and stock up for those holiday gatherings! Whenever friends ask me for a bourbon recommendation, my top pick is any bourbon from Garrison Brothers . They are my all-time favorite Texas distillery, and their whiskeys can compete with the best whiskeys from Kentucky. So, it should be no surprise there are two bourbons from Garrison Brothers in our 2024 Spirits gift guide. If Willy Wonka made a bourbon, it would be the Balmorhea from Garrison Brothers. While you could call the amber liquid ‘dessert in a glass’, it’s not sickly sweet or artificial. It’s a rich bourbon that tastes incredible whether enjoyed neat or on the rocks, and the afterburn reminds you this isn’t candy, but an adult beverage crafted with attention to detail. Official tasting notes: Bourbon candy: frozen fudgesicle bars, amaretto coffee, sticky buns, and pecan brittle. Thick, white chocolate syrup. Award-winning: 2-time US Micro Whisky of the Year and San Francisco Double Gold winner There’s no better description than that of Garrison Brothers: “Guadalupe is a sensuous, creamy liquid, exploding with unique flavors and character, making it the perfect bourbon for the connoisseur with a sophisticated palate.” Officially the tasting notes are: Full-on berry fruit. Ripe plums. Strawberry butter on flaky morning biscuits. Chocolate and cinnamon. Lavender honey. Toasted coffee beans. Unofficially this is one of the most unique and delicious bourbons we’ve ever tried and it makes the perfect gift for any bourbon lover. Aviation American Gin is created by a unique bartender / distiller partnership and now co-owned by actor and entrepreneur Ryan Reynolds, Aviation American Gin is crafted with a blend of botanicals delivering an approachable and balanced flavor profile. The perfect addition to any favorite cocktail and smooth enough to fly solo, “gin is just vodka after its wish was granted” Ryan Reynolds jokes. West End Gin is a premium, locally-crafted spirit that debuted this summer. This citrus-forward gin boasts 14 botanicals including juniper, orange peel, coriander, and cardamom. It’s a delightful dance between classic London Dry and contemporary styles, offering a clean, crisp, yet smooth taste profile (44% ABV). Every bottle sold donates $1 to community initiatives, starting right in Louisville’s West End. It’s like giving two gifts in one! Toki brings together old and new – the House of Suntory’s proud heritage and its innovative spirit – to create blended Japanese whisky that is both groundbreaking and timeless. This is a blended whisky with a blend of malt and grain whiskies from Suntory’s Hakushu, Yamazaki, and Chita distilleries. On the nose are aromas of basil, green apple, and honey, a light and refreshing whisky that mixes well. Haku Vodka is a craft vodka made with 100% Japanese white rice. Haku is distillation process involves being carefully filtrated through bamboo charcoal to produce a soft, mellow vodka. Koloa Rum was the first licensed distillery on the island of Kauaʻi, where sugarcane production is a traditional way of life. This award-winning island rum is crafted from pure cane sugar and rainwater from Mount Waiʻaleʻale. Koloa rum comes in several varieties and any bottle would make a great gift, but I recommend checking out the Koloa Kaua`i Coffee. Buchanan’s 18 Special Reserve Whisky is a blend of grain whiskies and single malts aged for at least 18 years in oak barrels that used to hold sherry. With a silky and delicate liquid, Buchanan’s 18 Special Reserve Whisky is a distinctive, rich, and well-rounded whisky with flavors of citrus, nuts, honey, and oak. Buchanan’s 18 Year Old Special Reserve is an icon of excellence among Scotch connoisseurs. The DELEÓN® bespoke-style bottle makes a bold statement and is a great addition to anyone’s home bar. DELEÓN® Tequila is aged in bold American Oak then finished in delicate French Oak wine casks, creating a balanced profile of rich caramel, toasted oak and dried fruit with a hint of silky vanilla on the finish. It is made from 100% Highland Blue Weber Agave. The original additive-free tequila. In 2023, Partida was awarded The Fifty Best’s Gold Medal for ‘Best Blanco Tequila. A wide and complex variety of herbal, earthy, and citrus notes dominate. There are hints of tropical fruits, vanilla, cooked agave, sweet potatoes, black pepper, volcanic minerals, and grapefruit. Origami Sake, is the first and only sake brewery in Arkansas. They use 100% locally sourced ingredients like the Arkansas rice and local mineral water. Silky-smooth, the White Lotus sake is simultaneously the most dynamic, drinkable, and versatile nigori (hazy)-style sake on the market. Its profile adapts to the flavors, feelings and temperatures of every season. It pairs perfectly with tacos, buffalo wings, pork roast, and caprese. Available at select retailers including H-E-B, Total Wine and More, Spec’s, etc (locate stores here ). SRP $24.99 /750mL bottle This vibrant sake has ripe cantaloupe, honeydew, and pear notes with a subtle umami backbone. It’s a versatile food-pairing sake that is equally enjoyable on its own. Pairs perfectly with gouda, smoked salmon, smash burgers and ramen. Available at select retailers including H-E-B, Total Wine and More, Spec’s, etc (locate stores here ). SRP $24.99/750mL bottle
A teen riding an e-bike has been hit by a ute after swerving into traffic on the Central Coast, prompting a police appeal for information. Login or signup to continue reading Police were called to Minnesota Road, Hamlyn Terrace about 8.15pm December 12 after reports a cyclist was hit by a car. Police were told a 14-year-old boy was riding an e-bike in a southerly direction in a bike lane, when it veered into traffic and was struck by a white utility. The white utility failed to stop and left before police arrived. The boy was treated by paramedics and taken to John Hunter Hospital for treatment. He remains there in a stable condition. A crime scene was established and police started investigating the circumstances surrounding the crash. As inquiries continue, investigators have released an image of a vehicle seen in the area at the time of the incident. Police wish to speak with the driver of the vehicle, who may be able to assist with inquiries. Anyone with information, CCTV footage and or dashcam vision in relation to the crash is urged to contact Crime Stoppers on 1800 333 000. Sage Swinton is a news reporter who was born and bred in the Hunter. She has been with the Newcastle Herald since June 2020. Sage Swinton is a news reporter who was born and bred in the Hunter. She has been with the Newcastle Herald since June 2020. DAILY Today's top stories curated by our news team. Also includes evening update. WEEKDAYS Grab a quick bite of today's latest news from around the region and the nation. WEEKLY The latest news, results & expert analysis. WEEKDAYS Catch up on the news of the day and unwind with great reading for your evening. WEEKLY Get the editor's insights: what's happening & why it matters. WEEKLY Love footy? We've got all the action covered. WEEKLY Every Saturday and Tuesday, explore destinations deals, tips & travel writing to transport you around the globe. WEEKLY Get the latest property and development news here. WEEKLY Going out or staying in? Find out what's on. WEEKDAYS Sharp. Close to the ground. Digging deep. Your weekday morning newsletter on national affairs, politics and more. WEEKLY Follow the Newcastle Knights in the NRL? Don't miss your weekly Knights update. TWICE WEEKLY Your essential national news digest: all the big issues on Wednesday and great reading every Saturday. WEEKLY Get news, reviews and expert insights every Thursday from CarExpert, ACM's exclusive motoring partner. TWICE WEEKLY Get real, Australia! Let the ACM network's editors and journalists bring you news and views from all over. AS IT HAPPENS Be the first to know when news breaks. DAILY Your digital replica of Today's Paper. Ready to read from 5am! DAILY Test your skills with interactive crosswords, sudoku & trivia. Fresh daily!‘Access Hollywood’ host Kit Hoover, husband Crowley Sullivan separating after 25 years of marriage