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NoneeGain Announces Extension to Stock Repurchase Program
NoneThe military's tradition of tracking Santa Claus on his gravity-defying sweep across the globe will carry on this Christmas Eve, even if the U.S. government shuts down, officials said Friday. Each year, at least 100,000 kids call into the North American Aerospace Defense Command to inquire about Santa’s location. Millions more follow online. “We fully expect for Santa to take flight on Dec. 24 and NORAD will track him," the U.S.-Canadian agency said in a statement. On any other night, NORAD is scanning the heavens for potential threats, such as last year's Chinese spy balloon. But on Christmas Eve, volunteers in Colorado Springs, Colorado, are fielding questions like, “When is Santa coming to my house?” and, “Am I on the naughty or nice list?” The endeavor is supported by local and corporate sponsors, who also help shield the tradition from Washington dysfunction. Bob Sommers, 63, a civilian contractor and NORAD volunteer, told The Associated Press that there are "screams and giggles and laughter” when families call in, usually on speakerphone. Sommers often says on the call that everyone must be asleep before Santa arrives, prompting parents to say, "Do you hear what he said? We got to go to bed early." NORAD's annual tracking of Santa has endured since the Cold War, predating ugly sweater parties and Mariah Carey classics. Here's how it began and why the phones keep ringing. The origin story is Hollywood-esque It started with a child's accidental phone call in 1955. The Colorado Springs newspaper printed a Sears advertisement that encouraged children to call Santa, listing a phone number. A boy called. But he reached the Continental Air Defense Command, now NORAD, a joint U.S. and Canadian effort to spot potential enemy attacks. Tensions were growing with the Soviet Union, along with anxieties about nuclear war. Air Force Col. Harry W. Shoup picked up an emergency-only “red phone” and was greeted by a tiny voice that began to recite a Christmas wish list. “He went on a little bit, and he takes a breath, then says, ‘Hey, you’re not Santa,’” Shoup told The Associated Press in 1999. Realizing an explanation would be lost on the youngster, Shoup summoned a deep, jolly voice and replied, “Ho, ho, ho! Yes, I am Santa Claus. Have you been a good boy?” Shoup said he learned from the boy's mother that Sears mistakenly printed the top-secret number. He hung up, but the phone soon rang again with a young girl reciting her Christmas list. Fifty calls a day followed, he said. In the pre-digital age, the agency used a 60-by-80-foot (18-by-24-meter) plexiglass map of North America to track unidentified objects. A staff member jokingly drew Santa and his sleigh over the North Pole. The tradition was born. “Note to the kiddies,” began an AP story from Colorado Springs on Dec. 23, 1955. “Santa Claus Friday was assured safe passage into the United States by the Continental Air Defense Command.” In a likely reference to the Soviets, the article noted that Santa was guarded against possible attack from "those who do not believe in Christmas.” Is the origin story humbug? Some grinchy journalists have nitpicked Shoup's story, questioning whether a misprint or a misdial prompted the boy's call. In 2014, tech news site Gizmodo cited an International News Service story from Dec. 1, 1955, about a child's call to Shoup. Published in the Pasadena Independent, the article said the child reversed two digits in the Sears number. "When a childish voice asked COC commander Col. Harry Shoup, if there was a Santa Claus at the North Pole, he answered much more roughly than he should — considering the season: ‘There may be a guy called Santa Claus at the North Pole, but he’s not the one I worry about coming from that direction,'" Shoup said in the brief piece. In 2015, The Atlantic magazine doubted the flood of calls to the secret line, while noting that Shoup had a flair for public relations. Phone calls aside, Shoup was indeed media savvy. In 1986, he told the Scripps Howard News Service that he recognized an opportunity when a staff member drew Santa on the glass map in 1955. A lieutenant colonel promised to have it erased. But Shoup said, “You leave it right there,” and summoned public affairs. Shoup wanted to boost morale for the troops and public alike. “Why, it made the military look good — like we’re not all a bunch of snobs who don’t care about Santa Claus,” he said. Shoup died in 2009. His children told the StoryCorps podcast in 2014 that it was a misprinted Sears ad that prompted the phone calls. “And later in life he got letters from all over the world,” said Terri Van Keuren, a daughter. "People saying ‘Thank you, Colonel, for having, you know, this sense of humor.’” A rare addition to Santa's story NORAD's tradition is one of the few modern additions to the centuries-old Santa story that have endured, according to Gerry Bowler, a Canadian historian who spoke to the AP in 2010. Ad campaigns or movies try to “kidnap” Santa for commercial purposes, said Bowler, who wrote “Santa Claus: A Biography.” NORAD, by contrast, takes an essential element of Santa's story and views it through a technological lens. In a recent interview with the AP, Air Force Lt. Gen. Case Cunningham explained that NORAD radars in Alaska and Canada — known as the northern warning system — are the first to detect Santa. He leaves the North Pole and typically heads for the international dateline in the Pacific Ocean. From there he moves west, following the night. “That's when the satellite systems we use to track and identify targets of interest every single day start to kick in,” Cunningham said. “A probably little-known fact is that Rudolph’s nose that glows red emanates a lot of heat. And so those satellites track (Santa) through that heat source.” NORAD has an app and website, www.noradsanta.org, that will track Santa on Christmas Eve from 4 a.m. to midnight, mountain standard time. People can call 1-877-HI-NORAD to ask live operators about Santa’s location from 6 a.m. to midnight, mountain time.
Alberta announces future coal mining policy plan, industry consults
The advancement of technology never stops, and with it, the demands of apps and operating systems evolve continuously. WhatsApp , the world’s most widely used messaging platform, adapts to the latest innovations to ensure optimal security and functionality. However, these improvements come at a cost: every year, some older devices fall off the compatibility list. Starting in 2025, a new range of smartphones will no longer support WhatsApp, forcing their users to consider upgrading their devices if they wish to continue using the service. Below, we explain the details and share the full list of affected phones. Why Does WhatsApp Stop Supporting Certain Phones? WhatsApp periodically reviews the operating systems it can support to implement its security updates and features. According to the platform, older devices often lack the technical capacity to meet these new demands. “Every year, we analyze which devices and software are the oldest and have the fewest users. It’s also possible that those devices lack the latest security updates or the functionality required to run WhatsApp,” states WhatsApp’s help center. From May 5, 2025, WhatsApp will only be compatible with devices running Android OS 5.0 and later, as well as iPhones with iOS 15.1 and above. This decision excludes a range of models from different brands that will no longer support the app. Updated List of Affected Devices The official list published by WhatsApp includes several popular models that were once trendsetters but will now become obsolete for the application. Apple Samsung Motorola Sony LG Lenovo Huawei Notifications and Measures for Users WhatsApp has confirmed that before the application ceases to support an operating system, users will receive in-app notifications. These alerts will include reminders about the need to update the device’s operating system. In some cases, updating the software might be enough to continue using WhatsApp. However, many of the devices listed will not be able to support newer versions of their operating systems due to hardware limitations, meaning a device upgrade will be inevitable. What Are Your Options if Your Phone Is on the List? If your smartphone is among the affected models, it’s essential to evaluate whether it’s time to upgrade. The current market offers devices that are safer, faster, and equipped with better features, even in budget-friendly ranges. Additionally, upgrading your device will not only ensure uninterrupted access to WhatsApp but also provide an enhanced experience with other applications. The advancement of technology is inevitable, but it’s also an opportunity to adapt to new standards and enjoy the benefits of innovation. If your phone is one of those losing compatibility in 2025, consider this an invitation to explore the modern options the smartphone world has to offer. Nació en Lima en 1992. Ejerció estudios de traducción y pedagogía, pero su amor por el fútbol hizo que se interesara por el periodismo deportivo. En 2013 entró al Diario Depor para cubrir el campo de las noticias internacionales y desde ese entonces ha ganado mucha experiencia en medios digitales.
Alberta announces future coal mining policy plan, industry consults
Aadi Bioscience Transforms with In-Licensing of Novel ADC Portfolio, $100 Million Sale of FYARRO® and $100 Million PIPE Financing
Irvine, Dec. 20, 2024 (GLOBE NEWSWIRE) -- Irvine, California, December 20, 2024 – UnitedAg is proud to announce its recognition as a Top Workplaces 2024 winner by the Orange County Register . This esteemed award is based on employee feedback gathered through a confidential survey conducted by Energage, LLC, a leading employee engagement technology partner. The survey evaluated key facets of workplace culture, including feeling Respected & Supported , being Enabled to Grow , and feeling Empowered to Execute . "Earning a Top Workplaces award is a badge of honor for companies, especially because it comes authentically from their employees," said Eric Rubino, CEO of Energage. "In today's market, it's vital for leaders to listen to and amplify employee voices. Top Workplaces do this exceptionally well, and it pays dividends." UnitedAg's survey results placed it among the industry's best: Top 9% for having staff that believes in the organization's values and goals. Top 1% for providing exceptional benefits. Top 2% for encouraging new ideas and innovation. Top 12% for upholding and demonstrating strong core values. "At UnitedAg, we are dedicated to fostering an environment where employees feel valued, supported, and empowered to grow," shared Chana Hauben, Vice President of Human Resources. "This recognition underscores the passion and dedication of our entire team. We are honored to be named a Top Workplace." UnitedAg's workplace culture thrives on collaboration, trust, and a shared commitment to excellence . By emphasizing teamwork, accountability, and respect , UnitedAg ensures its employees are not only supported but also equipped to make a lasting impact on its members and the agricultural community. Through open communication, a can-do attitude, and continuous improvement , UnitedAg is proud to champion a culture of empowerment, adaptation, and purposeful leadership. For more information about UnitedAg and its innovative solutions for the agricultural community, visit www.unitedag.org. ### About UnitedAg: UnitedAg is a member-owned agricultural trade association dedicated to providing comprehensive health benefits, fostering the next generation of agricultural leaders, and advocating for members' interest with lawmakers. Our mission is to support the sustainability and success of our members and the agricultural sector through tailored health benefits, leadership development, and legislative advocacy. Attachment Top Workplace Award © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
The Russian Direct Investment Fund (RDIF) has announced the launch of an alliance within the BRICS group aimed at joint development of Artificial Intelligence (AI). RDIF chief executive, Kirill Dmitriev made the announcement on Wednesday on the sidelines of the AI Journey conference in Moscow. Over 20 companies from six of the bloc’s member-states (Russia, China, India, Brazil, Iran and the UAE) have already joined the BRICS+AI alliance. Among the 50+ companies reportedly in favour of creating an alliance are universities, medical companies, pharmaceutical developers, financial infrastructure developers, telecommunications innovators, manufacturers of electric batteries and of semiconductors, according to Dmitriev. The new alliance will focus on digital technologies in the public and commercial sectors, according to RDIF. “This is particularly important given the fact that many Western countries are seeking to limit the access of BRICS to AI technologies,” Dmitriev said, underlining the “important role” of the new alliance. The alliance could ensue that the BRICS group develops AI technologies “faster and more powerfully,” through joint developments, the RDIF chief executive stressed. RDIF is Russia’s sovereign wealth fund created by the government in 2011 to make investments in companies of high-growth sectors of the Russian economy. The idea of creating BRICS+AI alliance was presented to Russian President Vladimir Putin during the BRICS Kazan Summit in October. Addressing the AI conference on Wednesday, Putin said that the development of the technology is crucial for Russia’s scientific and ideological sovereignty, while stressing the country’s readiness to partner internationally with innovators. BRICS was initially comprised of Brazil, Russia, India, China, and South Africa, and expanded when Egypt, Iran, Ethiopia, and the United Arab Emirates officially became members on January 1, 2024. Last month, Russian ally Belarus announced that it had also officially become a BRICS partner country. Such status has been also awarded to Indonesia, according to Russian Deputy Foreign Minister Aleksandr Pankin. ‘Partner country’ status provides for permanent participation in special sessions of BRICS summits and foreign ministers’ meetings, as well as other high-level events. Partners can also contribute to the group’s outcome documents. Bolivian Foreign Minister Celinda Sosa Lunda revealed in November that her nation had received an invitation from Russia to become a partner country of BRICS, saying they “responded positively to the invitation.” The list of aspiring partners has not been officially announced, but media reports have also mentioned Algeria, Cuba, Kazakhstan, Nigeria, Türkiye, Uganda, Uzbekistan, and Vietnam as potential candidates.Lefant M210 Pro Robot vacuum: Powerful, affordable, and smart cleaning for just $169.90
Russian military personnel killed five unarmed Ukrainian prisoners of war last month, the Donetsk Region Prosecutor's Office reported on Friday. The prosecutor's office said that Russian troops stormed Ukrainian positions near the city of Vuhledar, in Donetsk Oblast, during an offensive in which five defenders were captured on October 2. Citing operational data, it said one was killed in a forest belt, while four were taken to the road at gunpoint, where they too were shot. "The killing of prisoners of war is a gross violation of the Geneva Conventions and qualifies as a serious international crime," the report said. It added that investigative actions are being carried out to establish the full circumstances of the incident, with the pre-trial investigation being carried out by the Main Directorate of the Security Service of Ukraine in Donetsk and Luhansk regions. Newsweek has contacted the Russian defense ministry for comment via email on Saturday outside of standard working hours. On Saturday, Lieutenant General Kyrylo Budanov said Kyiv is aware of Russian "execution lists" targeting Ukrainian teachers, journalists, priests, and others. "[The execution lists] were supposed to include teachers of the Ukrainian language, literature, history, ATO [Anti-Terrorist Operation] veterans, journalists, scientists, writers, priests of the Orthodox Church of Ukraine and other denominations who supported Ukraine, public and political figures, heads of state authorities and self-government," said Budanov. The intelligence head also said that "Ukrainophobia" has affected the entire society of Russia. "The genocide of Ukrainians is not only the state policy of the Russian Federation, but also a mandatory social conviction from above," he said. Moscow launched a hypersonic missile strike this week on the central Ukrainian city of Dnipro, targeting a military facility. The attack utilized the experimental Oreshnik hypersonic missile, an intermediate-range weapon that can reportedly be equipped with either nuclear or conventional warheads. In a televised address, Russian President Vladimir Putin said the strike was a response to Ukraine's deployment of U.S. and British long-range missiles, which have been used to target sites within Russia. "No one in the world has weapons like these," Putin said. President Joe Biden greenlit the use of U.S.-supplied Army Tactical Missile Systems (ATACMS) for strikes inside Russian territory in a significant policy shift announced last weekend. Biden justified the move as a response to the involvement of North Korean troops in the conflict. Do you have a story we should be covering? Do you have any questions about this article or the war in Ukraine? Contact LiveNews@newsweek.comSocial Security tackles overpayment ‘injustices,’ but problems remain
Visa Teams With WhiteBIT to Offer Crypto-Focused Debit CardAadi Enters into Exclusive License for Three-Asset ADC Portfolio Developed through a Collaboration between WuXi Biologics and HANGZHOU DAC Aadi Enters Agreement to Sell FYARRO ® and Associated Infrastructure to KAKEN Pharmaceutical for $100M ; Announces PIPE Financing of $100M Cumulative Capital Expected to Fund Operations into Late 2028, Including Anticipated Clinical Data for the ADC Portfolio Co-Founder and Former CEO of ProfoundBio, Baiteng Zhao, Appointed to Aadi Board of Directors Aadi to Hold Webcast and Conference Call on December 20 at 8:00 AM EST LOS ANGELES , Dec. 19, 2024 /PRNewswire/ -- Aadi Bioscience, Inc. (NASDAQ: AADI) today announced it has entered into an exclusive license agreement for development and global commercialization of a three-asset portfolio of preclinical, next-wave antibody-drug conjugates (ADCs), in collaboration with WuXi Biologics (2269.HK), a leading global Contract Research, Development and Manufacturing Organization (CRDMO), and HANGZHOU DAC BIOTECHNOLOGY CO., LTD. ( HANGZHOU DAC), a global leader in ADC innovation. Per the terms of the license agreement, Aadi is granted exclusive rights to certain patents and know-how pertaining to three preclinical ADC programs leveraging HANGZHOU DAC's CPT113 linker payload technology targeting each of Protein Tyrosine Kinase 7 (PTK7), Mucin-16 (MUC16) and Seizure Related 6 Homolog (SEZ6). Aadi will pay aggregate upfront payments of $44 million for in-licensing such ADC programs. Additionally, Aadi is obligated to pay cumulative development milestone payments of up to $265 million , cumulative commercial milestone payments of up to $540 million and single-digit royalties of sales. To support this transaction, Aadi entered into a subscription agreement with certain qualified institutional buyers and accredited investors for a private investment in public equity ("PIPE") financing that is expected to result in gross proceeds of approximately $100 million , before deducting placement agent fees and other offering expenses. The Company is selling an aggregate of 21,592,000 shares of its common stock ("Common Stock") at a price of $2.40 per share, representing a premium of approximately 3.4% to the closing price on December 19, 2024 on Nasdaq, and pre-funded warrants ("Pre-Funded Warrants") to purchase up to an aggregate of 20,076,500 shares of Common Stock at a purchase price of $2.3999 per Pre-Funded Warrant share. The syndicate was led by Ally Bridge Group, with participation from new investors OrbiMed, Invus, Kalehua Capital and other accredited investors, Tae Han co-founder of ProfoundBio, as well as existing investors, including Avoro Capital, KVP Capital and Acuta Capital Partners. The PIPE financing is expected to close in the first half of 2025, subject to stockholder vote and satisfaction of customary closing conditions. "I'm thrilled to announce our partnership with WuXi Biologics and HANGZHOU DAC to bring forward this thoughtfully selected ADC portfolio. We were deliberate in identifying broadly expressed tumor targets where first-generation ADCs have already shown proof of concept. With our next wave ADC portfolio, we aim to build upon these earlier therapies to deliver improved outcomes for people living with cancer," said David Lennon , PhD, President and CEO of Aadi Bioscience. "The financing underscores the confidence our investors have in both the potential of this portfolio and the strength of Aadi's management team." About the ADC Portfolio Each of the three ADC assets utilizes HANGZHOU DAC's CPT113 ADC platform, which consists of a highly stable yet cleavable linker that delivers a Topoisomerase I (TOPO1) inhibitor payload. The CPT113 platform's linker stability and novel payload has the potential to be highly competitive among the next generation ADC platforms. To effectively leverage the CPT113 platform, Aadi selected tumor targets that are upregulated in high-potential cancer indications and where clinical efficacy has been demonstrated by first-generation ADCs. These assets were discovered through the collaborative efforts of WuXi Biologics and HANGZHOU DAC, utilizing the innovative antibody discovery platform provided by WuXi Biologics and advanced linker-payload technology provided by HANGZHOU DAC. "Leveraging our advanced antibody discovery service, we're glad to enable Aadi to accelerate the discovery of precision therapies targeting some of the most challenging cancers," said Dr. Chris Chen , CEO of WuXi Biologics. "This collaboration underscores our wide recognition as an industry leader in discovery service solutions, and further validates our ability to provide integrated discovery technology platforms for global partners to develop next-generation modalities. We look forward to partnering with Aadi and HANGZHOU DAC to expeditiously move these assets forward into clinical development and benefit patients worldwide." " HANGZHOU DAC's CPT-ADC platform is designed to enable next wave ADC capabilities that surpass first-generation technologies, including two programs already in clinical development in China ," said Dr. Robert Y. Zhao , President and CEO of HANGZHOU DAC Biotechnology. "As a global leader in ADC innovation, we are excited to partner with Aadi and WuXi Biologics to deliver this promising portfolio to patients." Aadi to Sell FYARRO for $100 Million , Cumulative Capital Expected to Fund Operations into Late 2028 In a separate agreement, KAKEN Pharmaceutical Co., Ltd., an R&D driven pharmaceutical company in Japan , has entered into a stock purchase agreement under which KAKEN will acquire Aadi Subsidiary, Inc. and all of its assets, including FYARRO ® (sirolimus protein-bound particles for injectable suspension) (albumin-bound) and associated infrastructure, including the majority of Aadi employees who support the FYARRO ® business. FYARRO is approved by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa), with cumulative revenue of $25.2 million reported over the prior four quarters ended September 30, 2024 . Per the terms of the agreement, Kaken will pay Aadi $100 million in cash at closing, subject to certain adjustments. The transaction is expected to close in the first half of 2025, subject to Aadi stockholder approval and certain closing conditions. Upon the closing of this transaction, KAKEN will also acquire the rights to the Aadi name and trademark. "We are enormously proud of the impact FYARRO has had for people with PEComa, and Kaken's capabilities, coupled with the proven track record of the Aadi team, ensures physicians and patients will continue to have access to this critical treatment," said Lennon. The net proceeds from the PIPE financing and the sale of FYARRO, together with the Company's existing cash, cash equivalents and marketable securities are expected to fund operations into late-2028, including anticipated clinical data readouts for the ADC portfolio. Baiteng Zhao Appointed to the Board of Directors, Brings Significant ADC Expertise Baiteng Zhao, PhD, joins Aadi's board of directors. Zhao co-founded ProfoundBio, a clinical stage next-gen ADC developer, in 2018 and served as the Chairman and CEO of the company until it was acquired by Genmab for $1.8 billion in May 2024 . Prior to ProfoundBio, Dr. Zhao worked at Seagen (now part of Pfizer) for more than eight years and was responsible for the modeling and simulation strategies for the development pipeline and supported preclinical and clinical development of ADC drug candidates. "We are delighted to welcome Baiteng to our Board. His deep expertise and successful track record in ADC development will be instrumental as we tenaciously move this exciting portfolio forward," said Caley Castelein , MD, Chair of the Board of Directors of Aadi Bioscience. "I am thrilled to join the Board at this pivotal moment for Aadi," said Baiteng Zhao, PhD, Board of Directors of Aadi Bioscience and co-founder of ProfoundBio. "PTK7, MUC16 and SEZ6 represent highly promising targets that are commonly overexpressed in cancers with significant unmet therapeutic needs. Coupled with an advanced linker-payload platform that has the potential to enable next-gen ADCs, I believe Aadi is uniquely positioned to make a meaningful impact on patient outcomes. I look forward to collaborating with the leadership team and fellow Board directors to advance these innovative programs and drive transformative progress for patients." Advisors Leerink Partners is serving as financial advisor to Aadi on the sale of FYARRO and the licensing of the ADC portfolio. Jefferies LLC is acting as exclusive placement agent for the PIPE financing. Wilson Sonsini Goodrich & Rosati, P.C. is serving as legal counsel to Aadi. McDermott Will & Emery LLP is serving as legal counsel to Kaken. Cooley LLP is serving as legal counsel to Jefferies LLC. Nomura Securities Co., Ltd. is serving as financial advisor to KAKEN. Conference Call Information The Aadi management team is hosting a conference call and webcast tomorrow, Friday, December 20 th at 8:00 AM EST ( 5:00 AM PST ) to discuss these updates. Participants may access a live webcast of the call and the associated slide presentation on these data through the "Investors & News" page of the Aadi Bioscience website at aadibio.com . To participate via telephone, please register in advance at this link . Upon registration, all telephone participants will receive a confirmation email detailing how to join the conference call, including the dial-in number along with a unique passcode and registrant ID that can be used to access the call. A replay of the conference call and webcast will be archived on the Company's website for at least 30 days. Additional Information for Stockholders This communication relates to the proposed sale of FYARRO and the proposed PIPE financing and may be deemed to be solicitation material in respect of such transactions. In connection with these proposed transactions, Aadi will file a Proxy Statement with the SEC. This communication is not a substitute for the Proxy Statement or any other documents that Aadi may file with the SEC or send to Aadi stockholders in connection with the proposed transactions. Before making any voting decision, investors and securityholders are urged to read the Proxy Statement and all other relevant documents filed or that will be filed with the SEC in connection with the proposed transactions as they become available because they will contain important information about the proposed transactions and related matters. Stockholders may obtain a copy of the Proxy Statement and other documents the Company files with the SEC (when they are available) through the website maintained by the SEC at www.sec.gov , as well as on the Investor and News section of Aadi's website at www.aadibio.com . Certain stockholders of Aadi holding approximately 36% of Aadi's outstanding shares, as of the date hereof, including members of its board of directors and related entities, have entered into voting and support agreements in favor of KAKEN Pharmaceutical and Aadi, pursuant to which such stockholders have agreed to vote in favor of the stock purchase transaction with KAKEN Pharmaceutical and the other transactions described above. Participants in the Solicitation Aadi and its respective directors and executive officers may be deemed to be participants in the solicitation of proxies from the stockholders of Aadi in connection with the proposed transactions. Information about Aadi's directors and executive officers is set forth in Aadi's definitive proxy statement filed with the SEC on April 26, 2024 , and in subsequent filings made by Aadi with the SEC. Other information regarding the interests of such individuals, as well as information regarding Aadi's directors and executive officers and other persons who may be deemed participants in the proposed transactions, will be set forth in the Proxy Statement and other relevant materials to be filed with the SEC when they become available. You may obtain free copies of these documents as described in the preceding paragraph. No Offer or Solicitation This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities nor a solicitation of any vote or approval with respect to the proposed transactions or otherwise, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction. The offer and sale of securities of Aadi described above are being made in a transaction not involving a public offering and the securities have not been registered under the Securities Act of 1933, as amended, and may not be reoffered or resold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements. Concurrently with the execution of the subscription agreement, the Company and the investors entered into a registration rights agreement pursuant to which the Company has agreed to file, following the closing of the PIPE financing, a registration statement with the SEC registering the resale of the shares of Common Stock and the shares of Common Stock underlying the Pre-Funded Warrants sold in the PIPE financing. About Aadi Bioscience Aadi is a precision oncology company with a vision to make bold choices in applying technology to efficiently deliver improved precision oncology therapies for people living with difficult-to-treat cancers. More information on the Company is available on the Aadi website at www.aadibio.com and connect with us on LinkedIn. Forward-Looking Statements This press release contains certain forward-looking statements regarding the business of Aadi Bioscience that are not a description of historical facts within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are based on the Company's current beliefs and expectations and may include, but are not limited to, statements relating to: the timing and completion of the proposed sale of FYARRO to Kaken Pharmaceuticals and the anticipated timing of the closing of the transaction; expectations regarding the timing, closing and completion of the PIPE financing; Aadi's expected cash position at the closing and cash runway of the company following the sale of FYARRO and PIPE financing; the future operations of Aadi; the development and potential benefits of any of Aadi's product candidates, including the preclinical ADC assets proposed to be licensed from WuXi; anticipated preclinical and clinical development activities and related timelines, including the expected timing for announcement of data and other preclinical and clinical results and potential submission of IND filings for one or more product candidates; and other statements that are not historical fact. Actual results could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks associated with (i) the risk that the conditions to the closing of the proposed sale of FYARRO or the PIPE financing are not satisfied, including the failure to timely obtain stockholder approval for the transactions, if at all; (ii) uncertainties as to the timing of the consummation of the proposed transactions and the ability of each of Kaken and Aadi to consummate the proposed sale of FYARRO; (iii) risks related to Aadi's ability to manage its operating expenses and its expenses associated with the proposed transactions pending the closing; (iv) risks related to the failure or delay in obtaining required approvals from any governmental or quasi-governmental entity necessary to consummate the proposed transactions; (v) unexpected costs, charges or expenses resulting from the transactions; (vii) potential adverse reactions or changes to business relationships resulting from the announcement or completion of the proposed sale of FYARRO or the proposed PIPE financing; (vii) the uncertainties associated with Aadi's product candidates, as well as risks associated with the preclinical and clinical development and regulatory approval of product candidates, including potential delays in the completion of preclinical studies and clinical trials; (viii) risks related to the inability of Aadi to obtain sufficient additional capital to continue to advance these product candidates; (ix) uncertainties in obtaining successful preclinical and clinical results for product candidates and unexpected costs that may result therefrom; (x) risks related to the failure to realize any value from product candidates being developed and anticipated to be developed in light of inherent risks and difficulties involved in successfully bringing product candidates to market; and (xi) risks associated with the possible failure to realize certain anticipated benefits of the proposed sale of FYARRO or the proposed PIPE financing, including with respect to future financial and operating results. Additional risks and uncertainties that could cause actual outcomes and results to differ materially from those contemplated by the forward-looking statements are included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 , including under the caption "Item 1A. Risk Factors," and in Aadi's subsequent Quarterly Reports on Form 10-Q, and elsewhere in Aadi's reports and other documents that Aadi has filed, or will file, with the SEC from time to time and available at www.sec.gov . All forward-looking statements in this press release are current only as of the date hereof and, except as required by applicable law, Aadi undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise. All forward-looking statements are qualified in their entirety by this cautionary statement. This cautionary statement is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Contact: IR@aadibio.com View original content to download multimedia: https://www.prnewswire.com/news-releases/aadi-bioscience-transforms-with-in-licensing-of-novel-adc-portfolio-100-million-sale-of-fyarro-and-100-million-pipe-financing-302336743.html SOURCE Aadi BioscienceKYIV, Ukraine — NATO and Ukraine will hold emergency talks Tuesday after Russia attacked a central city with an experimental, hypersonic ballistic missile. escalating the nearly 33-month-old war. The conflict is “entering a decisive phase,” Poland’s Prime Minister Donald Tusk said Friday, and “taking on very dramatic dimensions.” Ukraine’s parliament canceled a session as security was tightened following Thursday’s Russian strike on a military facility in the city of Dnipro. In a stark warning to the West, President Vladimir Putin said in a nationally televised speech the attack with the intermediate-range Oreshnik missile was in retaliation for Kyiv’s use of U.S. and British longer-range missiles capable of striking deeper into Russian territory. Russian President Vladimir Putin speaks Friday during a meeting with the leadership of the Russian Ministry of Defense, representatives of the military-industrial complex and developers of missile systems at the Kremlin in Moscow. Putin said Western air defense systems would be powerless to stop the new missile. Ukrainian military officials said the missile that hit Dnipro reached a speed of Mach 11 and carried six nonnuclear warheads, each releasing six submunitions. Speaking Friday to military and weapons industries officials, Putin said Russia will launch production of the Oreshnik. “No one in the world has such weapons,” he said. “Sooner or later, other leading countries will also get them. We are aware that they are under development. “We have this system now,” he added. “And this is important.” Putin said that while it isn’t an intercontinental missile, it’s so powerful that the use of several of them fitted with conventional warheads in one attack could be as devastating as a strike with strategic — or nuclear — weapons. Gen. Sergei Karakayev, head of Russia’s Strategic Missile Forces, said the Oreshnik could reach targets across Europe and be fitted with nuclear or conventional warheads, echoing Putin’s claim that even with conventional warheads, “the massive use of the weapon would be comparable in effect to the use of nuclear weapons.” In this photo taken from a video released Friday, a Russian serviceman operates at an undisclosed location in Ukraine. Kremlin spokesman Dmitry Peskov kept up Russia's bellicose tone on Friday, blaming “the reckless decisions and actions of Western countries” in supplying weapons to Ukraine to strike Russia. "The Russian side has clearly demonstrated its capabilities, and the contours of further retaliatory actions in the event that our concerns were not taken into account have also been quite clearly outlined," he said. Hungarian Prime Minister Viktor Orbán, widely seen as having the warmest relations with the Kremlin in the European Union, echoed Moscow’s talking points, suggesting the use of U.S.-supplied weapons in Ukraine likely requires direct American involvement. “These are rockets that are fired and then guided to a target via an electronic system, which requires the world’s most advanced technology and satellite communications capability,” Orbán said on state radio. “There is a strong assumption ... that these missiles cannot be guided without the assistance of American personnel.” Orbán cautioned against underestimating Russia’s responses, emphasizing that the country’s recent modifications to its nuclear deployment doctrine should not be dismissed as a “bluff.” “It’s not a trick ... there will be consequences,” he said. Czech Republic's Foreign Minister Jan Lipavsky speaks to journalists Friday during a joint news conference with Ukraine's Foreign Minister Andriiy Sybiha in Kyiv, Ukraine. Separately in Kyiv, Czech Foreign Minister Jan Lipavský called Thursday’s missile strike an “escalatory step and an attempt of the Russian dictator to scare the population of Ukraine and to scare the population of Europe.” At a news conference with Ukrainian Foreign Minister Andrii Sybiha, Lipavský also expressed his full support for delivering the necessary additional air defense systems to protect Ukrainian civilians from the “heinous attacks.” He said the Czech Republic will impose no limits on the use of its weapons and equipment given to Ukraine. Three lawmakers from Ukraine's parliament, the Verkhovna Rada, confirmed that Friday's previously scheduled session was called off due to the ongoing threat of Russian missiles targeting government buildings in central Kyiv. In addition, there also was a recommendation to limit the work of all commercial offices and nongovernmental organizations "in that perimeter, and local residents were warned of the increased threat,” said lawmaker Mykyta Poturaiev, who said it's not the first time such a threat has been received. Ukraine’s Main Intelligence Directorate said the Oreshnik missile was fired from the Kapustin Yar 4th Missile Test Range in Russia’s Astrakhan region and flew 15 minutes before striking Dnipro. Test launches of a similar missile were conducted in October 2023 and June 2024, the directorate said. The Pentagon confirmed the missile was a new, experimental type of intermediate-range missile based on its RS-26 Rubezh intercontinental ballistic missile. Thursday's attack struck the Pivdenmash plant that built ICBMs when Ukraine was part of the Soviet Union. The military facility is located about 4 miles southwest of the center of Dnipro, a city of about 1 million that is Ukraine’s fourth-largest and a key hub for military supplies and humanitarian aid, and is home to one of the country’s largest hospitals for treating wounded soldiers from the front before their transfer to Kyiv or abroad. We're all going to die someday. Still, how it happens—and when—can point to a historical moment defined by the scientific advancements and public health programs available at the time to contain disease and prevent accidents. In the early 1900s, America's efforts to improve sanitation, hygiene, and routine vaccinations were still in their infancy. Maternal and infant mortality rates were high, as were contagious diseases that spread between people and animals. Combined with the devastation of two World Wars—and the Spanish Flu pandemic in between—the leading causes of death changed significantly after this period. So, too, did the way we diagnose and control the spread of disease. Starting with reforms as part of Roosevelt's New Deal in the 1930s, massive-scale, federal interventions in the U.S. eventually helped stave off disease transmission. It took comprehensive government programs and the establishment of state and local health agencies to educate the public on preventing disease transmission. Seemingly simple behavioral shifts, such as handwashing, were critical in thwarting the spread of germs, much like discoveries in medicine, such as vaccines, and increased access to deliver them across geographies. Over the course of the 20th century, life expectancy increased by 56% and is estimated to keep increasing slightly, according to an annual summary of vital statistics published by the American Academy of Pediatrics in 2000. Death Records examined data from the Centers for Disease Control and Prevention to see how the leading causes of death in America have evolved over time and to pinpoint how some major mortality trends have dropped off. According to a report published in the journal Annual Review of Public Health in 2000, pneumonia was the leading cause of death in the early 1900s, accounting for nearly 1 in 4 deaths. By the time World War I ended in 1918, during which people and animals were housed together for long periods, a new virus emerged: the Spanish Flu. Originating in a bird before spreading to humans, the virus killed 10 times as many Americans as the war. Many died of secondary pneumonia after the initial infection. Pneumonia deaths eventually plummeted throughout the century, partly prevented by increased flu vaccine uptake rates in high-risk groups, particularly older people. Per the CDC, tuberculosis was a close second leading cause of death, killing 194 of every 10,000 people in 1900, mainly concentrated in dense urban areas where the infection could more easily spread. Eventually, public health interventions led to drastic declines in mortality from the disease, such as public education, reducing crowded housing, quarantining people with active disease, improving hygiene, and using antibiotics. Once the death rates lagged, so did the public health infrastructure built to control the disease, leading to a resurgence in the mid-1980s. Diarrhea was the third leading cause of death in 1900, surging every summer among children before the impacts of the pathogen died out in 1930. Adopting water filtration, better nutrition, and improved refrigeration were all associated with its decline. In the 1940s and 1950s, polio outbreaks killed or paralyzed upward of half a million people worldwide every year. Even at its peak, polio wasn't a leading cause of death, it was a much-feared one, particularly among parents of young children, some of whom kept them from crowded public places and interacting with other children. By 1955, when Jonah Salk discovered the polio vaccine, the U.S. had ended the "golden age of medicine." During this period, the causes of mortality shifted dramatically as scientists worldwide began to collaborate on infectious disease control, surgical techniques, vaccines, and other drugs. From the 1950s onward, once quick-spreading deadly contagions weren't prematurely killing American residents en masse, scientists also began to understand better how to diagnose and treat these diseases. As a result, Americans were living longer lives and instead succumbing to noncommunicable diseases, or NCDs. The risk of chronic diseases increased with age and, in some cases, was exacerbated by unhealthy lifestyles. Cancer and heart disease shot up across the century, increasing 90-fold from 1900 to 1998, according to CDC data. Following the post-Spanish Flu years, heart disease killed more Americans than any other cause, peaking in the 1960s and contributing to 1 in 3 deaths. Cigarette smoking rates peaked at the same time, a major risk factor for heart disease. Obesity rates also rose, creating another risk factor for heart disease and many types of cancers. This coincides with the introduction of ultra-processed foods into diets, which plays a more significant role in larger waistlines than the increasing predominance of sedentary work and lifestyles. In the early 1970s, deaths from heart disease began to fall as more Americans prevented and managed their risk factors, like quitting smoking or taking blood pressure medicine. However, the disease remains the biggest killer of Americans. Cancer remains the second leading cause of death and rates still indicate an upward trajectory over time. Only a few types of cancer are detected early by screening, and some treatments for aggressive cancers like glioblastoma—the most common type of brain cancer—have also stalled, unable to improve prognosis much over time. In recent years, early-onset cancers, those diagnosed before age 50 or sometimes even earlier, have seen a drastic rise among younger Americans. While highly processed foods and sedentary lifestyles may contribute to rising rates, a spike in cancer rates among otherwise healthy young individuals has baffled some medical professionals. This follows the COVID-19 pandemic that began in 2020. At its peak, high transmission rates made the virus the third leading cause of death in America. It's often compared to the Spanish Flu of 1918, though COVID-19 had a far larger global impact, spurring international collaborations among scientists who developed a vaccine in an unprecedented time. Public policy around issues of safety and access also influences causes of death, particularly—and tragically—among young Americans. Gun control measures in the U.S. are far less stringent than in peer nations; compared to other nations, however, the U.S. leads in gun violence. Firearms are the leading cause of death for children and teens (around 2 in 3 are homicides, and 1 in 3 are suicides), and deaths from opioids remain a leading cause of death among younger people. Globally, the leading causes of death mirror differences in social and geographic factors. NCDs are primarily associated with socio-economic status and comprise 7 out of 10 leading causes of death, 85% of those occurring in low- and middle-income countries, according to the World Health Organization. However, one of the best health measures is life expectancy at birth. People in the U.S. have been living longer lives since 2000, except for a slight dip in longevity due to COVID-19. According to the most recent CDC estimates, Americans' life expectancy is 77.5 years on average and is expected to increase slightly in the coming decades. Story editing by Alizah Salario. Additional editing by Kelly Glass. Copy editing by Paris Close. Photo selection by Lacy Kerrick. This story originally appeared on Death Records and was produced and distributed in partnership with Stacker Studio. Get local news delivered to your inbox!
Dy CM inaugurates IT Expo 20243 Penny Stocks With 10% to 210% Upside PotentialROME (AP) — In 2020, it was a run to the Champions League quarterfinals just as Bergamo was becoming the epicenter of the coronavirus pandemic . Last season, it was an upset victory over Bayer Leverkusen in the Europa League final to end the German club’s European-record unbeaten run at 51 games. Atalanta keeps on surprising and its latest exploit was moving atop Serie A following a 3-1 win at Parma on Saturday for its seventh straight win in the Italian league. And to think that coach Gian Piero Gasperini considered leaving Atalanta toward the end of last season. Now, Gasperini has the chance to guide “La Dea” (The Goddess), as the team is nicknamed, to its first ever Italian league title. There’s a long way to go, though, and it should be noted that Atalanta is level on points with second-place Inter Milan, which routed Hellas Verona 5-0 earlier, and that Napoli has a chance to reclaim the lead when it hosts Roma on Sunday. Also Saturday, AC Milan and Juventus drew 0-0 at the San Siro in a match with few chances from both sides. Milan produced one shot on goal and Juventus created two. Atalanta's Mateo Retegui scored his league-leading 12th goal of the season, Ederson made it 2-0 before the break and Europa League final hero Ademola Lookman restored the two-goal advantage after Matteo Cancellieri had pulled one back for Parma. Retegui’s fourth headed goal of the season put him atop that category across Europe’s five major leagues, according to Opta, while Lookman volleyed in a cross from Juan Cuadrado after having two goals disallowed. Gasperini was sent off midway through the second half for protests. But he was smiling in the stands at the final whistle. Atalanta's 34 goals are the most in Italy, and trail only Barcelona (42), Bayern Munich (36) and Paris Saint-Germain (36) across Europe's top five leagues. Atalanta has won two and drawn two in the Champions League this season. Marcus Thuram scored twice for defending champion Inter at Verona. Inter was missing top striker Lautaro Martinez, who was out sick. But five goals in the first half made Lautaro’s absence a non-issue. Joaquin Correa opened the scoring 17 minutes in, Thuram then scored twice before more goals from Stefan de Vrij and Yann Aurel Bisseck. Correa nearly added another in second-half stoppage time but his effort hit the woodwork. Inter's only loss across all competitions this season was a derby defeat to Milan in September. AP soccer: https://apnews.com/hub/soccer
Russia announces BRICS+AI allianceChinese President Xi Jinping will preside over a day of celebrations in Macau and inaugurate the city's new leader on Friday to mark 25 years since the former colony was returned to China. Macau is regarded by China as a shining example of its "One Country, Two Systems" model, and Xi praised the city as a "pearl in the nation's palm" at the start of his three-day visit. The Chinese casino hub has grown from a Portuguese trading outpost to the world's casino capital by gaming revenue and a popular destination for Chinese tourists. When Macau reverted to Chinese rule on December 20, 1999, Beijing promised that the city's "capitalist system and way of life shall remain unchanged for 50 years". Arriving in the city on Wednesday, Xi lauded Macau's "world-recognised success" in implementing the "One Country, Two Systems" framework and said the city had a bright future. "Macau is a pearl in the nation's palm, and I have always kept in my thoughts its development and the welfare of all its people," Xi said. The Chinese president added that he would use his trip for "extensive and in-depth exchanges with our friends from all places, and discuss plans for Macau's development". Friday's festivities will be centred around the inauguration of Sam Hou-fai, the former president of Macau's apex court, as the city's fourth post-handover leader, replacing Ho Iat-seng. Security was tight around the city on Thursday, with roadblocks set up around an event venue and authorities increasing checks on inbound visitors. - Casino hub - Following the end of 442 years of Portuguese rule, Macau's fortunes have risen in lockstep with China's economic growth. It is the only place in China where casino gambling is permitted and has long surpassed Las Vegas as the world's top casino hub, fuelled by two decades of Chinese visitor spending. Macau, which has a resident population of 687,000, saw just over 29 million visitor arrivals in the first 10 months of the year. Its GDP has soared from $6.4 billion in 1999 to more than $47 billion last year, and its population is the richest in China on a per capita basis. Under orders from Beijing to diversify the economy, Macau leaders have proposed fields such as financial services, technology and Chinese medicine as new economic drivers. But as of November, gaming-related taxes still made up 81 percent of government revenue and experts say Macau is years away from weaning itself off casino wealth. Xi on Thursday visited the Macau University of Science and Technology and was "briefed on the development of two state-level key laboratories" that involved Chinese medicine and planetary science, according to state news agency Xinhua. He also visited the Guangdong-Macao In-Depth Cooperation Zone on Hengqin Island, speaking to residents and people there in charge of planning, construction, management and services, Xinhua reported. Hengqin Island, a landmass adjacent to Macau and three times its size, was partly leased by Beijing to Macau to boost its land supply for non-gaming development. hol/oho/sco
Stock market today: Wall Street ends little changed after giving up a big morning gain
This Futurist Predicts a Coming ‘Living Intelligence’ and AI SupercycleOur community members are treated to special offers, promotions and adverts from us and our partners. You can check out at any time. More info The unsolved murder of child beauty queen JonBenet Ramsey, which has left detectives stumped for nearly 30 years, could finally be seeing a breakthrough. For ages, suspicion has loomed over JonBenet's family, despite them being cleared by police in 2008 with an apology when DNA evidence indicated an "unknown male" at the crime scene. JonBenet was only six years old when she endured torture, sexual assault, and was murdered on Boxing Day in 1996. Her mother, Patsy Ramsey, discovered a ransom note demanding £94,000 ($118,000) for her daughter's safe return on their Boulder, Colorado mansion's staircase on the morning of December 26. But later that day, JonBenet's lifeless body was found by her father in a disused boiler room in the basement. The case went cold for decades, with the investigation reaching a standstill, but now a Netflix documentary series exploring the enigma has sparked renewed public interest. JonBenet's father, John Ramsey, now 81, is hopeful that the fresh focus from the series, Cold Case: Who Killed JonBenet Ramsey? will bring them closer to securing justice for his daughter, even if it means confronting the bizarre theories that often accompany such attention. John, whose wife Patsy tragically lost her battle with cancer in 2006, was recently left stunned after receiving an anonymous letter from a woman who sensationally alleged that her ex-husband was the person responsible for the death of their young daughter. The cryptic message, which included a phone number, read: "I've kept this inside for as long as I can - please, please call me," However, when John tried to call the number, it went unanswered. In an interview with the Daily Mail, John revealed that he did not feel negatively about the incident, nor did he harbour any anger towards the person who sent the letter, whom he suspected was likely a prankster. Instead, he viewed it as a positive development, as it helped shift the focus away from suspicions that a member of his family was responsible. He said: "You know, the police were doing nothing and had done nothing for 28 years, quite frankly, other than trying to explain away the evidence so they could prosecute Patsy or me." "And they couldn't do it so they thought "oh well, we know who did it, but we can't prove it so we'll just forget about it. I've kept this inside for as long as I can - please, please call me," "I think the documentary has brought a lot of renewed interest and it has kept pressure on the police to do their job." JonBenet's body was found with her mouth covered in duct tape, her hands bound, and a garotte made from cord and a paintbrush from Patsy's art supplies lodged in her neck. Initially, local police were unwilling to accept that an intruder was responsible, instead convincing themselves that JonBenet's parents were to blame. Their speculation was that Patsy may have unintentionally killed her daughter over a bed-wetting incident, or that Burke, then nine years old, could have been responsible due to a sibling dispute, and the couple then staged it as a murder scene. The public was captivated, especially when videos of JonBenet participating in beauty pageants, where she won titles such as Little Miss Colorado and National Miss Tiny Beauty, surfaced. Misinformation given to local and international media, who descended on the affluent suburb in the foothills of the Rocky Mountains, only fueled the suspicion surrounding the Ramseys. However, there have now been two significant developments: one of the original detectives on the case, seen by the Ramseys as a "roadblock" in the investigation, has been disciplined and is now retired. A new police chief was brought in, with whom John claims to have a good relationship, and he is pleading with him to use the latest technology to conduct more testing on the unidentified male DNA. John says this method has been successful in cracking many cold cases. Secondly, the FBI is now involved, and they have a profile of the killer, which John says was someone in their 20s or 30s, who was obsessed with movies. He also says the agents believe that the murder wasn't about JonBenet, but possibly someone with a grievance against him.