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WALTHAM, Mass., Dec. 03, 2024 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology therapies for people living with cancer, today announced that, effective December 1, 2024, the company granted non-qualified stock options to purchase 8,400 shares of its common stock to one new employee under Xilio Therapeutics' 2022 Inducement Stock Incentive Plan. The stock options have an exercise price of $1.09 per share, which is equal to the closing price of the company's common stock on November 29, 2024. Each stock option will have a ten-year term and will vest as to 25% of the shares underlying the stock option on the first anniversary following commencement of employment, and the remaining 75% of the shares underlying each stock option will vest in 36 equal monthly installments thereafter, subject to continued service with the company or any of its subsidiaries through each applicable vesting date. The stock options are subject to the terms and conditions of Xilio Therapeutics' 2022 Inducement Stock Incentive Plan, as well as the terms and conditions of the stock option agreement covering the grant and were made as an inducement material to the individual entering into employment with the company in accordance with Nasdaq Listing Rule 5635(c)(4). About Xilio Therapeutics Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines, antibodies, bispecifics and immune cell engagers. Learn more by visiting www.xiliotx.com and follow us on LinkedIn ( Xilio Therapeutics, Inc .). This press release contains hyperlinks to information that is not deemed to be incorporated by reference in this press release. Investor and Media Contact: Scott Young Vice President, Investor Relations and Corporate Communications [email protected]
Donald Trump Jr. has emerged as the most influential Trump family member in the transition as the president-elect builds the most controversial cabinet in modern U.S. history, according to a half dozen sources with knowledge of his role, elevating inexperienced loyalists over more qualified candidates for top positions in his administration. Trump, who fiercely prizes loyalty, has long relied on family members for political advice, but which relative has his ear is known to vary. This time, it is Don Jr., who has helped cabinet contenders sink or rise to the fore – from championing Senator JD Vance as Trump's running mate to blocking former Secretary of State Mike Pompeo from joining the cabinet, according to the sources, who include donors, personal friends and political allies. Don Jr. is due to join conservative venture capital fund 1789 Capital, although one of the sources said he will continue to host his politics-focused podcast and support candidates that espouse Trump's brand of politics. He will provide advice to his father in the White House, the source added, although they cautioned that Don Jr. was unlikely to be involved in day-to-day deliberations. Sign-up for Your Vote: Text with the USA TODAY elections team. Don Jr. and the Trump-Vance transition team did not respond to a request for comment. In addition to ensuring candidates are loyal to his father, Don Jr. typically seeks out contenders who embrace an anti-establishment worldview, including protectionist economic policies, and a reduction in military interventions and overseas aid, according to a handful of the sources and Don Jr.'s own comments on social media site X and in public. Two of the candidates Don Jr. championed may face a rocky confirmation process in the Senate: Robert F. Kennedy Jr., who Trump plans to nominate as the top U.S. health official, and Tulsi Gabbard, who Trump plans to nominate as intelligence chief. Kennedy is an environmental activist who has spread misinformation on vaccines. Gabbard, a former Democratic congresswoman, implied that Russian President Vladimir Putin had valid grounds for invading Ukraine and stirred controversy when she met Syrian President Bashar al-Assad in the midst of his bloody crackdown on dissidents in 2017. Influential – to a point Don Jr. was also instrumental in lobbying his father to pick his close friend Vance as Trump's running mate. Vance was popular with Trump's base, but his anti-corporate rhetoric, opposition to Ukraine aid and past comments panning some Democratic women as "childless cat ladies" gave some donors and supporters pause. Trump was ultimately happy with Vance, giving Don Jr. extra political capital as an adviser during the transition, one of the sources added. Not all of Don Jr.'s picks have landed jobs. He was keen on Ric Grenell, a personal friend and former ambassador to Germany, getting secretary of state, according to a separate source familiar with the matter. His father ended up picking Senator Marco Rubio, whose views are deemed by Trump's core supporters as too traditional and internationalist. Two of the sources close to Don Jr. said he does not weigh in on all personnel decisions and is not working on the transition process or at Mar-a-Lago full time. He is also not expected to play a big role in vetting candidates for lower-level jobs, one of the sources close to him said. "The reality this time is we actually know what we're doing," Don Jr. told Fox News earlier this month. "And it's about surrounding my father with people who are both competent and loyal." Following in his sister's footsteps Trump's daughter Ivanka and her husband Jared Kushner were prominent in his 2016 presidential campaign, the subsequent transition and throughout his first term. This time, they are far less active, although Kushner, formerly Trump's senior adviser who focused on the Middle East, told Reuters that he is briefing real estate investor Steve Witkoff on his new job as special envoy to the region. "I have been working with Witkoff to get him up to speed on Trump's past efforts," Kushner said through a spokesperson. A half-dozen sources close to Kushner said they expect him to be involved in Middle Eastern policy in an unofficial capacity, with the goal of normalizing relations between Israel and Saudi Arabia under an expansion of the 2020 Abraham Accords. Kushner helped broker the accords, a series of normalization agreements between Israel and Arab nations. Kushner, Ivanka and sibling Eric Trump, who runs the Trump Organization business, do not plan to join the new administration, according to their representatives as well as sources. One source close to the transition said Trump does not appear to need his family for advice as much as in the past because of aides like Susie Wiles, who helped to run the most disciplined of his election campaigns to date. Trump has named Wiles as his chief of staff, a powerful position in Washington. "Stuff is really buttoned down," the source said of Trump's current team. "He may not need the family this time like he used to."Jamichael Stillwell scores 22 to lead Milwaukee to 69-65 victory over St. Thomas-Minnesota
The Toronto Transit Commission will continue to accept tokens, tickets and day passes until the end of May next year, reversing a contentious decision to stop accepting the legacy fares . The change was made this week after TTC chair Jamaal Myers put forward a motion at Tuesday’s TTC board meeting to continue accepting the legacy fares until June 1. “Our customers bought this in good faith,” Myers said at the meeting. “They paid money for it ... I think it’s only fair and reasonable just to give customers the opportunity to spend the tickets that they paid for.” The motion, which was adopted by the board, also includes a provision that gives Wheel-Trans riders until Dec. 31, 2025 to use the fares, a decision made because they potentially use the TTC less frequently than other riders. The TTC said it wants to get rid of the legacy fares in order to streamline payments across the system. The Eglinton Crosstown and Finch LRTs will not accept tickets or tokens when they open. Less than one per cent of riders pay with tickets and tokens, according to the TTC, which stopped selling them near the end of 2019. Third-party retailers sold them . But many riders were surprised by the transit commission’s announcement in October that it intended to discontinue the fares as of Jan. 1, although the TTC said at Tuesday’s meeting that it had announced the possibility of phasing out tickets and tokens as early as 2019, and had handed out information pamphlets about the change to customers as well as posted information on social media. At the board meeting, a number of speakers complained about the lack of a trade-in program and the lack of time the TTC gave riders to use the legacy fares, both of which could have contributed to a windfall for the transit agency of $24 million, the value of tokens and tickets still in circulation. The transit advocate group TTCriders was one of a number of community organizations that signed an the TTC to let transit user exchange tokens and tickets for single-use Presto tickets. Rev. Maria Christina Conlon of the Davenport Perth Community Ministry, a United Church in Toronto’s west end, told the Star she put her name to the petition because she’d heard from several individuals who were concerned about using the tokens and tickets that the ministry had given them before Jan. 1. “If they stop accepting them or using them, where did the money go?” said Conlon, adding it would have been “another blow for people that need transportation.” Conlon said one man had saved 100 tokens, which represented a sizable sum for anyone who is helped by her ministry, which she said includes people working multiple jobs or on social assistance. Tickets have been used since the TTC came into existence in 1921. Tokens were introduced in 1954, the year that the TTC opened Canada’s first subway, the Yonge line, in 1954.
Multi-year collaboration aims to expand artificial intelligence (AI) adoption, foster innovation, and enhance industry-specific solutions for diverse business leaders NEW YORK , Dec. 3, 2024 /PRNewswire/ -- Genpact (NYSE: G), a global professional services and solutions firm delivering outcomes that shape the future, today announced a multi-year Strategic Collaboration Agreement (SCA) with Amazon Web Services (AWS) with plans to accelerate the adoption of AI and empower business leaders across functions to harness its transformative potential. By simplifying access to cutting-edge data and AI technologies, Genpact and AWS are allowing a broad range of decision-makers—from CFOs and COOs to procurement and operations leaders—to drive innovation within their organizations. "Our collaboration with AWS is focused on bringing AI innovations directly to the forefront of decision-making across every line of business," said Murat Aksu , Global Leader for Partnerships, Genpact. "This Strategic Collaboration Agreement will break down traditional barriers to AI adoption, making it accessible to business leaders beyond the CIO's office, and help our clients accelerate value through AI-driven insights and solutions." While AI innovations were previously centralized within IT functions, this expanded collaboration ensures that advanced technologies can now be seamlessly integrated into all business lines. Genpact's collaboration with AWS democratizes AI capabilities, offering tailored solutions that meet the unique needs of multiple business areas, empowering them to solve complex challenges with agility and efficiency. "Thanks to the Genpact and AWS collaboration, we've been able to become a fully cloud-native fixed-annuity provider," said Bob Guilmette , Chief Information Officer, Revol One Financial. "With AWS and Genpact's advanced technology expertise, we are streamlining operations, accelerating product launches, and enhancing digital customer experiences, positioning ourselves for sustainable growth and a competitive edge over legacy insurers." As an AWS Premier Tier Services Partner, Genpact brings deep expertise in AI, data and analytics. With nearly 1,000 certified AWS professionals, Genpact helps clients unlock the full potential of AWS services, including Amazon Connect and Amazon OpenSearch, to modernize operations and scale AI solutions. Genpact's numerous offerings in AWS Marketplace include: "We are expanding our collaboration with Genpact to drive AI transformation across industries," said Rima Olinger , Managing Director, North America Partners, AWS. "Genpact's industry expertise and advanced technology capabilities make them a valuable partner in helping organizations harness AI effectively, empowering business leaders to leverage data-driven insights and achieve their strategic objectives." This collaboration underscores the value of Genpact and AWS to provide flexibility and unlock greater business value for customers across industries. To learn how Genpact and AWS help enterprises across every industry and function, click here . About Genpact Genpact (NYSE: G) is a global professional services and solutions firm delivering outcomes that shape the future. Our 125,000+ people across 30+ countries are driven by our innate curiosity, entrepreneurial agility, and desire to create lasting value for clients. Powered by our purpose – the relentless pursuit of a world that works better for people – we serve and transform leading enterprises, including the Fortune Global 500, with our deep business and industry knowledge, digital operations services, and expertise in data, technology, and AI. Get to know us at genpact.com and on LinkedIn , X , YouTube , and Facebook . MEDIA CONTACT: Sue Martenson Genpact Media Relations +1 978-905-9582 susan.martenson@genpact.com View original content to download multimedia: https://www.prnewswire.com/news-releases/genpact-signs-strategic-collaboration-agreement-with-aws-to-accelerate-ai-adoption-302321582.html SOURCE Genpact Ltd.
Heavy travel day starts with brief grounding of all American Airlines flights
Dispatch from South Korea (3)
NoneWASHINGTON — American Airlines briefly grounded flights nationwide Tuesday because of a technical problem just as the Christmas travel season kicked into overdrive and winter weather threatened more potential problems for those planning to fly or drive. Government regulators cleared American flights to get airborne about an hour after the Federal Aviation Administration ordered a national ground stop for the airline. The order, which prevented planes from taking off, was issued at the airline's request. The airline said in an email that the problem was caused by trouble with vendor technology that maintains its flight operating system. An American Airlines employee wearing looks toward quiet check-in counters Tuesday in the American terminal at Miami International Airport in Miami. Dennis Tajer, a spokesperson for the Allied Pilots Association, a union representing American Airlines pilots, said the airline told pilots at 7 a.m. Eastern that there was an outage affecting the system known as FOS. It handles different types of airline operations, including dispatch, flight planning, passenger boarding, as well as an airplane's weight and balance data, he said. Some components of FOS have gone down in the past, but a systemwide outage is rare, Tajer said. Flights were delayed across American's major hubs, with only 37% leaving on time, according to Cirium, an aviation analytics company. Out of the 3,901 domestic and international American Airlines flights scheduled for Tuesday, 19 were canceled. Cirium noted that the vast majority of flights departed within two hours of their scheduled departure time. A similar percentage — 36% — arrived at their destinations as scheduled. Meanwhile, the flight-tracking site FlightAware reported that 3,712 flights entering or leaving the U.S., or serving domestic destinations, were delayed Tuesday, with 55 flights canceled. It did not show any flights from American Airlines. Cirium said Dallas-Fort Worth, New York's Kennedy Airport and Charlotte, North Carolina, saw the greatest number of delays. Washington, Chicago and Miami experienced considerably fewer delays. Travelers wait in line for security checks Tuesday at the Los Angeles International Airport in Los Angeles. Amid the travel problems, significant rain and snow were expected in the Pacific Northwest at least into Christmas Day. Showers and thunderstorms developed in the South. Freezing rain was reported in the Mid-Atlantic region near Baltimore and Washington, and snow fell in New York. Because the holiday travel period lasts weeks, airports and airlines typically have smaller peak days than they do during the rush around Thanksgiving, but the grind of one hectic day followed by another takes a toll on flight crews. Any hiccups — a winter storm or a computer outage — can snowball into massive disruptions. That is how Southwest Airlines stranded 2 million travelers in December 2022, and Delta Air Lines suffered a smaller but significant meltdown after a worldwide technology outage in July caused by a faulty software update from cybersecurity company CrowdStrike. Many flights during the holidays are sold out, which makes cancellations even more disruptive than during slower periods. That is especially true for smaller budget airlines that have fewer flights and fewer options for rebooking passengers. Only the largest airlines, including American, Delta and United, have "interline agreements" that let them put stranded customers on another carrier's flights. An American Airlines employee wearing a Santa Claus hat walks through the American terminal Tuesday at Miami International Airport in Miami. This will be the first holiday season since a Transportation Department rule took effect that requires airlines to give customers an automatic cash refund for a canceled or significantly delayed flight. Most air travelers were already eligible for refunds, but they often had to request them. Passengers still can ask to get rebooked, which is often a better option than a refund during peak travel periods. Finding a last-minute flight on another airline tends to be expensive. An American spokesperson said Tuesday was not a peak travel day for the airline — with about 2,000 fewer flights than the busiest days — so the airline had somewhat of a buffer to manage the delays. The groundings happened as millions of travelers were expected to fly over the next 10 days. The Transportation Security Administration expects to screen 40 million passengers through Jan. 2. Airlines expect to have their busiest days on Thursday, Friday and Sunday. American Airlines employees check in travelers Tuesday in the American terminal at Miami International Airport in Miami. Many flights during the holidays are sold out, which makes cancellations more disruptive than during slower periods. Even with just a brief outage, the cancellations have a cascading effect that can take days to clear up. About 90% of Americans traveling far from home over the holidays will be in cars, according to AAA. "Airline travel is just really high right now, but most people do drive to their destinations, and that is true for every holiday," AAA spokesperson Aixa Diaz said. Gasoline prices are similar to last year. The nationwide average Thursday was $3.04 a gallon, down from $3.13 a year ago, according to AAA. Charging an electric vehicle averages just under 35 cents per per kilowatt hour, but varies by state. Transportation-data firm INRIX says travel times on the nation's highways could be up to 30% longer than normal over the holidays, with Sunday expected to see the heaviest traffic. "It's not the destination, it's the journey," said American essayist Ralph Waldo Emerson. Ralph clearly was not among the travellers on one of more than 350 cancelled or 1,400 delayed flights after a worldwide tech outage caused by an update to Crowdstrike's "Falcon Sensor" software in July of 2023. U.S. airlines carried nearly 863 million travellers in 2023, with Canadian carriers accounting for another 150 million, many of whom experienced lost luggage, flight delays, cancellations, or were bumped off their flights. It's unclear how many of them were compensated for these inconveniences. Suffice it to say, posting a crabby rant on social media might temporarily soothe anger, but it won't put wasted money back in pockets. Money.ca shares what to know in order to be compensated for the three most common air travel headaches. Bags elected to go on a vacay without you? Check off the following: If you expect a large payout, think again. Tariffs (air carrier contracts) limit the compensation amounts for "loss of, damage to, or the delay in delivery of baggage or other personal property." In the case of Air Canada, the maximum payout is $1,500 per passenger in the currency of the country where the baggage was processed. To raise that limit, purchase a Declaration of Higher Value for each leg of the trip. The charge is $0.50 for each $100, in which case the payout limit is $2,500. For Delta Air Lines, passengers are entitled to up to $3,800 in baggage compensation, though how much you'll receive depends on your flight. Delta will pay up to $2,080 for delayed, lost, and damaged baggage for international travellers, almost half of what U.S. domestic passengers can claim. If your flight is marked delayed for more than 30 minutes, approach the gate agent and politely request food and hotel vouchers to be used within the airport or nearby. Different air carriers and jurisdictions have their own compensation policies when flights are delayed or cancelled. For example, under European Union rules, passengers may receive up to 600 Euros, even when travelling on a non-EU carrier. Similarly, the DOT states that travellers are entitled to a refund "if the airline cancelled a flight, regardless of the reason, and the consumer chooses not to travel." However, US rules regarding delays are complicated. Some air carriers, such as Air Canada, do not guarantee their flight schedules. They're also not liable for cancellations or changes due to "force majeure" such as weather conditions or labour disruptions. If the delay is overnight, only out-of-town passengers will be offered hotel accommodation. Nevertheless, many airlines do offer some compensation for the inconvenience. If your flight is marked delayed for more than 30 minutes, approach the gate agent and politely request food and hotel vouchers to be used within the airport or nearby. In terms of cash compensation, what you'll get can differ significantly based on things like departure location, time, carrier, and ticket class. The DOT offers a helpful delay and cancellations dashboard designed to keep travellers informed about their compensation rights. The dashboard is particularly helpful because, as the DOT states on its website, "whether you are entitled to a refund depends on a lot of factors—such as the length of the delay, the length of the flight, and your particular circumstances." The Canadian Transportation Agency is proposing air passenger protection regulations that guarantee financial compensation to travellers experiencing flight delays and cancellations, with the level of compensation varying depending on the situation and how much control the air carrier had. The proposed regulations include the following: The airline is obligated to complete the passenger's itinerary. If the new ticket is for a lower class of service, the air carrier would have to refund the cost difference; if the booking is in a higher class of service, passengers cannot be charged extra. If the passenger declines the ticket, the airline must give a full refund, in addition to the prescribed compensation. For overnight delays, the air carrier needs to provide hotel accommodation and transportation free-of-charge. Again, if you are unsatisfied, the Canadian Transportation Agency or Department of Transportation may advocate on your behalf. Passengers get bumped because airlines overbook. When this happens, the air carrier must compensate you. For international flights in the US, the rate is 200% of your one-way fare to your final destination, with a $675 maximum. If the airline does not make travel arrangements for you, the payout is 400% of your one-way fare to a maximum of $1,350. To qualify, you must check-in by the stated deadline, which on international flights can be up to 3 hours ahead. Keep in mind that if you accept the cash, you are no longer entitled to any further compensation, nor are you guaranteed to be rebooked on a direct flight or similar type of seat. Don't be too quick to give up your boarding pass. Negotiate for the best compensation deal that would include cash, food and hotel vouchers, flight upgrade, lounge passes, as well as mileage points. But avoid being too greedy—if the gate attendant is requesting volunteers and you wait too long, you'll miss the offer. According to Air Canada's tariff, if a passenger is involuntarily bumped, they'll receive $200, in cash or bank draft, for up to a two-hour delay; $400 for a 2-6 hours delay; and $800 if the delay is over six hours. (Air Canada was forced to raise its payouts in 2013 due to passenger complaints.) The new rules would raise the payout significantly: $900 for up to six hours; $1,800 for 6-9; and $2,400 for more than nine hours, all to be paid within 48 hours. Statistically speaking, Delta Airlines is the carrier most likely to bump. A few years ago, Delta raised its payout maximum to $9,950, while United Airlines tops out at $10,000. This story was produced by Money.ca and reviewed and distributed by Stacker. Get local news delivered to your inbox!
NEW YORK (AP) — The man accused of burning a woman to death inside a New York City subway train used a shirt to fan the flames, a prosecutor said Tuesday at his arraignment on murder charges. Sebastian Zapeta, 33, who federal immigration officials said is a Guatemalan citizen who entered the U.S. illegally, was not required to enter a plea and did not speak at the hearing in Brooklyn criminal court. Zapeta, wearing a white jumpsuit over a weathered black hooded sweatshirt, will remain jailed at the city's Rikers Island complex and is due back in court on Friday. His lawyer did not ask for bail. Zapeta is charged with two counts of murder, accusing him of intentionally killing the woman and killing her while committing arson. He is also charged with one count of arson. The top charge carries a maximum sentence of life in prison without parole. Brooklyn District Attorney Eric Gonzalez called the attack a “gruesome and senseless act of violence” and said it would be “met with the most serious consequences.” The apparently random attack occurred Sunday morning on an F train that was stopped at the Coney Island station. The victim's identification is still pending. Authorities say Zapeta approached the woman, who may have been sleeping in the train, and set her clothing on fire with a lighter. Zapeta then fanned the flames with a shirt, engulfing her in fire, Assistant District Attorney Ari Rottenberg said in court Tuesday. Zapeta then sat on a bench on the subway platform and watched, Rottenberg said. According to Rottenberg, Zapeta told detectives that he didn’t know what happened but identified himself in images of the attack. Zapeta's lawyer, public defender Andrew Friedman, did not speak to reporters after the arraignment. A message seeking comment was left for him. Video on social media appears to show some people looking on from the platform and at least one police officer walking by while the woman is on fire inside the train. NYPD Transit Chief Joseph Gulotta said Sunday that several officers responded to the fire and one stayed to keep the crime scene “the way it’s supposed to be" while the others went to get fire extinguishers and transit workers. “Officers who were on patrol on an upper level of that station smelled and saw smoke and went to investigate. What they saw was a person standing inside the train car fully engulfed in flames,” Police Commissioner Jessica Tisch said. They eventually put the fire out, but “unfortunately, it was too late,” Tisch said, and the woman was pronounced dead at the scene. Zapeta was taken into custody Sunday afternoon while riding a train on the same subway line after teenagers recognized him from images circulated by the police. A Brooklyn address for Zapeta released by police matches a shelter that provides housing and substance abuse support. The shelter did not immediately respond to a request for comment. Federal immigration officials said Zapeta was deported in 2018 but later reentered the U.S. illegally. The crime deepened a growing sense of unease among some New Yorkers about the safety of the subway system, amplified by graphic video of the attack that ricocheted across social media. “It creeped me out real bad,” said Deandre Nelson, 22. Others said the attack hasn’t changed their daily routine or how they feel about the subway. “I don’t think it gave me pause," said Collin Burroughs, 24. “I think it mostly just made me sad.” Overall, crime is down in the transit system compared to last year. Major felonies declined 6% between January and November compared to the same time period last year, according to data from the Metropolitan Transportation Authority. But murders are up, with nine killings this year through November compared to five during the same period last year. There have also been several high-profile incidents, including one in September where police inadvertently shot two bystanders and a fellow officer when they opened fire on a man holding a knife in front of a train. Earlier this month, a Manhattan jury acquitted former Marine Daniel Penny in the chokehold death last year of an agitated subway rider. The case became a flashpoint in debates over safety, homelessness and mental illness on the system. Policing the subway is difficult, given the vast network of trains moving between 472 stations. Each stop contains multiple entry points and, in many stations, multiple floors and platforms. This story has been corrected to show that the name of Zapeta's lawyer is Andrew Friedman, not Ed Friedman. Associated Press reporter Melissa Goldin contributed to this report.