
Seattle capital gains tax proposal falls short again
Moreover, the incident involving Big Bear serves as a reminder of the need for better education and awareness about wildlife conservation and coexistence. It is crucial for photographers and nature enthusiasts to understand the impact of their actions on wildlife and to take steps to minimize their disturbance. This includes following ethical guidelines for wildlife photography, such as maintaining a safe distance, using non-invasive equipment, and avoiding behaviors that could agitate or provoke animals.If you're looking for top stocks, there's no need to reinvent the wheel. The Securities and Exchange Commission makes it a breeze to follow the world's greatest investors. Every three months, the regulator has everyone with more than $100 million under management share their trading details with the public on a Form 13F filing. One billionaire investor whom investors of all sizes follow closely is Philippe Laffont of Coatue Management. Known for investing in a combination of tech and healthcare stocks, Laffont grew his fund to $26.9 billion at the end of September. Laffont and Coatue made a lot of money with Nvidia in the first half of 2024. At the end of June, Wall Street's favorite artificial intelligence ( AI ) stock was the fund's fourth-largest holding at a value of roughly $1.2 billion. His love for Nvidia found a limit. During the third quarter, Coatue sold 3.6 million shares of the high-flying AI stock, which was enough to reduce its stake by 26%. Nvidia has fallen out of favor at Coatue and been replaced by a pair of two drugmakers leading the anti-obesity niche. During the third quarter, Laffont increased his firm's stake in Novo Nordisk ( NVO -0.32% ) more than ninefold to $39 million. Coatue already had a large Eli Lilly ( LLY -1.38% ) stake that it raised by 20% to $220 million. 1. Novo Nordisk The drugs that Novo Nordisk and Eli Lilly market for the treatment of obesity and diabetes are flying off pharmacy shelves and have further to climb. A report from Morgan Stanley suggests the market for anti-obesity drugs could rise from $6 billion in 2023 to $105 billion in 2030. Novo's lead drug is semaglutide, a glucagon-line peptide-1 (GLP-1) agonist that the Food and Drug Administration (FDA) approved as Ozempic and Rybelsus to treat diabetes and later as Wegovy to treat obesity. In the first nine months of 2024, total semaglutide sales grew about 41% year over year to $19.8 billion. In a clinical trial leading to its approval as a weight management drug, Wegovy reduced patients' weight by 12.4% compared to a placebo. Novo Nordisk isn't stopping at Wegovy. It's developing a next-generation weight management treatment made from semaglutide and an amylin analog called CagriSema (cagrilintide). Treatment with CagriSema lowered patients' weight by a placebo-adjusted 20.4% on average after 68 weeks of treatment. 2. Eli Lilly Eli Lilly is another large pharmaceutical company with a blockbuster GLP-1 drug. Tirzepatide first earned FDA approval to treat diabetes in 2022 under the brand name Mounjaro. The FDA approved the same drug to treat obesity in 2023 under the brand name Zepbound. While semaglutide acts on GLP-1 alone, tirzepatide is a dual GLP-1 and GIP agonist. The dual action has improved its efficacy and sales trajectory. In trials leading to Zepbound's approval, it reduced patients' weight by a placebo-adjusted 17.8% on average after 72 weeks. Novo Nordisk still has a leading share of the market for GLP-1 drugs, but tirzepatide is gaining fast. Despite just two short years on the market, total tirzepatide sales during the first nine months of 2024 rose above $11 billion. CagriSema could disrupt tirzepatide's upward trajectory, but there's a good chance Eli Lilly will overtake Novo Nordisk as the leading seller of GLP-1 drugs. Although CagriSema's pivotal trial results were impressive, they pale in comparison to retatrutide, a triplet therapy Eli Lilly is testing. Retatrutide is a GLP-1/GIP agonist that also acts on glucagon receptors. In 2023, a phase 2 trial showed it lowered patients' weight by a placebo-adjusted 22.1% after 48 weeks. Time to buy? The GLP-1 drug market will be stuck in a game of tug-of-war between Eli Lilly and Novo Nordisk for the next several years. Tirzepatide will likely overtake semaglutide in another year or two, but it could fall to CagriSema. Novo Nordisk's next-generation anti-obesity candidate already finished a phase 3 trial and could earn FDA approval in 2025. Retatrutide began a phase 3 study in May of 2023 that should wrap up in January of 2026. If all goes as expected, CagriSema could be the top obesity treatment for about a year before the FDA looks at an application from Lilly for retatrutide. While we can reasonably look forward to rapid sales growth from their still-experimental GLP-1 candidates, the stock market is already pricing in a lot of success. Expectations are so high for Eli Lilly that it's probably best to avoid the stock for now. It's been trading for about 60 times forward-looking earnings estimates. At this steep valuation, any sign of trouble for tirzepatide or retatrutide could lead to heavy losses. Shares of Novo Nordisk recently tanked because CagriSema results don't appear competitive against retatrutide. At its recently beaten-down price, the pharmaceutical giant is trading for 27.9 times forward-looking earnings expectations. That's a steep price to pay for a drugmaker, but soaring demand for its GLP-1 drugs could allow it to grow into its valuation and provide market-beating gains to patient investors.
Giants' offense explodes in 45-33 win, knocking Colts out of playoff raceMany employees who have dedicated years of their lives to the club now find themselves questioning their place within the organization and wondering if they too could be targeted for removal. The swift and seemingly arbitrary nature of Ashworth's dismissal has left many staff members feeling vulnerable and exposed, unsure of where they stand in the eyes of the club's leadership.Ultimately, the property dispute was settled in court, but the damage done to the family's relationship was irreparable. The once-close bond between the parents and their daughter had been fractured beyond repair, leaving scars that would take a long time to heal.
The Xiaomi Smart Socket 3 is a popular choice among tech-savvy consumers for its reliability, functionality, and affordability. With the additional discount offered by South Hill, this smart home accessory becomes even more attractive to those looking to upgrade their living spaces with cutting-edge technology.Donald Trump Says Country Owes Jimmy Carter A 'Debt of Gratitude'
Jimmy Carter had the longest post-presidency of anyone to hold the office, and one of the most active. Here is a look back at his life. 1924 — Jimmy Carter was born on Oct. 1 to Earl and Lillian Carter in the small town of Plains, Georgia. 1928 — Earl Carter bought a 350-acre farm 3 miles from Plains in the tiny community of Archery. The Carter family lived in a house on the farm without running water or electricity. 1941 — He graduated from Plains High School and enrolled at Georgia Southwestern College in Americus. 1942 — He transferred to Georgia Institute of Technology in Atlanta. 1943 — Carter’s boyhood dream of being in the Navy becomes a reality as he is appointed to the U.S. Naval Academy in Annapolis, Maryland. 1946 — He received his naval commission and on July 7 married Rosalynn Smith of Plains. They moved to Norfolk, Virginia. 1946-1952 — Carter’s three sons are born, Jack in 1947, Chip in 1950 and Jeff in 1952. 1962-66 — Carter is elected to the Georgia State Senate and serves two terms. 1953 — Carter’s father died and he cut his naval career short to save the family farm. Due to a limited income, Jimmy, Rosalynn and their three sons moved into Public Housing Apartment 9A in Plains. 1966 — He ran for governor, but lost. 1967 — Jimmy and Rosalynn Carter’s fourth child, Amy, is born. 1971 — He ran for governor again and won the election, becoming Georgia’s 76th governor on Jan. 12. 1974 — Carter announced his candidacy for president. 1976 — Carter was elected 39th president on Nov. 2, narrowly defeating incumbent Gerald Ford. 1978 — U.S. and the Peoples’ Republic of China establish full diplomatic relations. President Carter negotiates and mediates an accord between Egypt and Israel at Camp David. 1979 — The Department of Education is formed. Iranian radicals overrun the U.S. Embassy and seize American hostages. The Strategic Arms Limitations Treaty is signed. 1980 — On March 21, Carter announces that the U.S. will boycott the Olympic Games scheduled in Moscow. A rescue attempt to get American hostages out of Iran is unsuccessful. Carter was defeated in his bid for a second term as president by Ronald Reagan in November. 1981 — President Carter continues to negotiate the release of the American hostages in Iran. Minutes before his term as president is over, the hostages are released. 1982 — Carter became a distinguished professor at Emory University in Atlanta, and founded The Carter Center. The nonpartisan and nonprofit center addresses national and international issues of public policy. 1984 — Jimmy and Rosalynn Carter volunteer one week a year for Habitat for Humanity, a nonprofit organization that helps needy people in the United States and in other countries renovate and build homes, until 2020. He also taught Sunday school in the Maranatha Baptist Church of Plains from the mid-’80s until 2020. 2002 — Awarded the Nobel Peace Prize. 2015 — Carter announced in August he had been diagnosed with melanoma that spread to his brain. 2016 — He said in March that he no longer needed cancer treatment. 2024 — Carter dies at 100 years old. Sources: Cartercenter.org, Plains Historical Preservation Trust, The Associated Press; The Brookings Institution; U.S. Navy; WhiteHouse.gov, Gallup
Fee Xiang, known for his impeccable timing and uproarious on-screen presence, is a veteran in the comedy scene, having charmed audiences with his quick wit and infectious energy for decades. Ma Dongxi, equally revered for his comedic prowess and versatile acting skills, brings a touch of sophistication and hilarity to every project he undertakes. Finally, Song Xiaobao, with his signature slapstick humor and endearing charm, rounds out the trio, completing a formidable lineup of comedic genius.
---In December 1978, Jimmy Carter – who has died aged 100 – outlined his belief that American strategic decisions abroad should be shaped by an adherence to human rights. “ Human rights is the soul of our foreign policy ... because human rights is the soul of our sense of nationhood.” In the sphere of foreign affairs, Jimmy Carter’s one term as US president (1977-1981) had some notable achievements. The most significant was the 1978 Camp David accords . Carter, Israeli prime minister Menachem Begin, and Egyptian president Anwar Sadat signed an agreement that saw Begin agree to relinquish the entire Sinai Peninsula, captured by Israel in the 1967 six-day war, in exchange for peace and full diplomatic relations with Egypt. This exemplified Carter’s belief in the power of American diplomacy and why US presidents should courageously assume the difficult task of peace-making . Twenty-five years later, and against the backdrop of the build-up to the second Gulf war, Carter was recognised for his role in the accords and awarded the 2002 Nobel peace prize. The Nobel committee said that while President George W. Bush was planning an invasion of Iraq: “former President Jimmy Carter was awarded the Peace Prize for undertaking peace negotiations, campaigning for human rights, and working for social welfare”. They added that the prize was in recognition of “his decades of untiring effort to find peaceful solutions to international conflicts, to advance democracy and human rights, and to promote economic and social development”. On leaving office in January 1981, Carter sought to use his status as a former president to engage in the issues and causes that mattered to him most. He established the Carter Center to pursue his own course of personal diplomacy. Starting in 1982, the centre has monitored more than 110 elections in 39 countries. Ahead of the 2020 US presidential election and as then president Donald Trump on refused to commit to a peaceful transition should he lose, the Carter Center took the extraordinary step of designating the US as a “backsliding” democracy . Devout diplomacy Carter, a devout Christian, maximised his personal relationships with former world leaders to promote democracy and human rights, support scientific work on eliminating diseases, and to mediate where possible to prevent conflict. His activism was not always appreciated by some of his White House successors, both Republican and Democrat. Randall Balmer , professor of religion at Dartmouth College, said that the former president’s personal brand of diplomacy could often complicate and even contradict contemporary US diplomatic initiatives. Carter was a member of The Elders , an independent group of global leaders working on peace promotion, social justice, climate change and global human rights. During his years of active membership Carter dedicated significant energy to the Israeli-Palestinian conflict , visiting the region on a number of occasions to support the Elders’ work. In the early 1990s the former president became involved in mediation work between the US State Department and several rogue states including North Korea and Libya. In 1994, Carter supported the US government’s diplomatic efforts to resolve an increasingly tense nuclear weapons’ situation with North Korean leader Kim Il Sung. Carter met with Kim in June 1994, becoming the first former US president to visit the country. The trip laid the groundwork for an eventual bilateral deal between North Korea and the US. The agreement saw North Korea pledge to freeze its plutonium weapons programme, while the US agreed to offer aid. Continued work in his 90s Carter continued to weigh-in on contemporary geopolitical events well into his 90s. He was openly critical when Trump announced in May 2018 that he was withdrawing the US from the Iran nuclear agreement , which had been negotiated by the Obama administration in 2015. He called Trump’s move a “serious mistake” . Carter felt that an international agreement made by an American president needed to be binding on all their successors and that by walking away from the Iran deal the US was signalling a “message to North Korea that if the United States signs an agreement, it may or may not be honored”. One of Carter’s major accomplishments since leaving office was his centre’s work in health care, and specifically the eradication of Guinea-worm disease. This is a parasitic infection caused by drinking contaminated water. The consequences of the illness , while not fatal, can incapacitate the sufferer and lead to permanent disability. The Carter Center committed to training over 100,000 village-based health care workers, invested in education programmes and provided water filters to protect people from swallowing the parasite. The results have been highly successful. According to the centre: “incidences of Guinea-worm disease have been reduced from an estimated 3.5 million in 1986 to 13 in 2023 , with the disease being eliminated in 17 countries”. Jimmy Carter’s commitment to human rights never went away and his concept of a human-rights focused foreign policy has become permanently encoded in the global conversation . The former president’s work brought him international acclaim, and illustrated why the nation’s leaders should reject short-sighted calculations that risk the US being complicit in human rights violations . Richard Hargy does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.
As the reigning UK Champion and the world number one, Trump's influence on the sport extends beyond his on-table success. He has become a role model for aspiring snooker players, a source of inspiration for fans, and a true ambassador for the game. His charisma, sportsmanship, and dedication to the sport have endeared him to millions and elevated snooker to new heights of popularity and relevance.