
Unlike scores of people who for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It’s a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It’s all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person’s response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn’t happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It’s not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn’t respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I’m hoping it’s slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content. Jonel Aleccia, The Associated PressNYT's Brooks: I Agree More with Musk, Vivek, But You Have to Secure Border FirstThe Detroit Lions will play without two high draft picks in rookie cornerbacks Terrion Arnold and Ennis Rakestraw Jr. while possibly getting back veteran Emmanuel Moseley against the host Indianapolis Colts on Sunday. Arnold was downgraded Saturday from questionable to out because of a groin injury. He was limited at practice on Thursday and participated in a full practice on Friday. The Lions drafted Arnold with the 24th overall pick of the 2024 NFL Draft out of Alabama. Arnold, 21, has started all 10 games and has 38 tackles and six passes defended. Rakestraw (hamstring) was placed on injured reserve after not practicing all week. He already had been ruled out for Sunday's game. Detroit picked Rakestraw in the second round (61st overall) out of Missouri. He has played in eight games and has six tackles. Rakestraw, 22, has played on 46 defensive snaps (8 percent) and 95 special teams snaps (42 percent). Moseley had full practice sessions all week and was activated from injured reserve on Saturday but was listed as questionable for Sunday. The 28-year-old is in his second season with Detroit and appeared in one game last season before going on IR in October 2023. He was placed on IR on Aug. 27 with a designation to return. Moseley played from 2018-22 for the San Francisco 49ers and had 162 tackles, four interceptions -- one returned for a touchdown -- and 33 passes defensed in 46 games (33 starts). Detroit elevated linebacker David Long on Saturday for game day. Long, 28, signed with the practice squad on Tuesday after the Miami Dolphins released him on Nov. 13. He had started six of eight games for the Dolphins this season and had 38 tackles. In other Lions news, the NFL fined wide receiver Jameson Williams $19,697 for unsportsmanlike conduct for making an obscene gesture during a touchdown celebration in last Sunday's 52-6 home win over the Jacksonville Jaguars, the NFL Network reported Saturday. Williams, 23, scored on a 65-yard pass from Jared Goff with 12:55 remaining in the third quarter. --Field Level MediaPresident-elect Donald Trump on Thursday named former Florida Attorney General Pam Bondi as his pick to serve as U.S. attorney general in his incoming administration, after Matt Gaetz withdrew from consideration earlier in the day. “For too long, the partisan Department of Justice has been weaponized against me and other Republicans - Not anymore,” Trump said in a Thursday post announcing the pick on his Truth Social platform. “Pam will refocus the DOJ to its intended purpose of fighting Crime, and Making America Safe Again. I have known Pam for many years — She is smart and tough, and is an AMERICA FIRST Fighter, who will do a terrific job as Attorney General!” Bondi is a longtime Trump ally and was one of his lawyers during his first impeachment trial when he was accused — but not convicted — of abusing his power as he tried to condition U.S. military assistance to Ukraine on that country investigating then-former Vice President Joe Biden. She has been a chair at the America First Policy Institute, a think tank set up by former Trump administration staffers. Bondi is from Tampa and spent more than 18 years as a prosecutor. She was Florida’s first female attorney general. This is a developing story and will be updated. The Associated Press contributed to this report.
Toxic site is leaking cancer-causing chemicals in Grand Prairie, Texas. When will it be cleaned?and AP The Libyan State Minister for communications and political affairs arrived in Damascus on Saturday to hold meetings with new Syrian officials. At the Al-Shaab Palace in Damascus, Libyan State Minister Walid Al-Lafi held talks with the Syrian HTS (Hayat Tahrir Al-Sham) leader Ahmad al-Sharaa. After the meeting, Al-Lafi told reporters that he discussed with the Syrian new Syrian officials the military and security issues between the two countries. “It was an important meeting, its importance is because of the timing and the cross files between Libya and Syria especially the military and security files and the consequences of the major events that took place in Syria on the region,” said Walid Al-Lafi. Foreign and Arab officials are flocking to Syria after the toppling of the former Syrian President Bashar Assad’s government, pledging cooperation, and support for the reconstruction of the devastated country and the peaceful transition of power.
FIFA report praises Saudi Arabia 2034 World Cup bid
FBI investigating ‘numerous bomb threats’ against Trump administration nomineesChampionship volleyball game featuring transgender player opens with players kneeling during national anthem
Florida 6, Carolina 0
US reels from rain and snow as second round of bad weather approaches for Thanksgiving weekWisconsin faces its first losing season in 23 years and the end of a bowl streak when the Badgers host arch-rival Minnesota on Friday in the annual Big Ten battle for Paul Bunyan's Axe. Minnesota (6-5, 4-4) lost to No. 4 Penn State 26-25. Wisconsin (5-6, 3-5 Big Ten) lost its fourth straight, 44-25, at Nebraska in a game that was not as close as the score. "Well 1890 is the first time we played this football team coming up and this is what it's all about," Minnesota coach P.J. Fleck said of the rivalry. "And you wouldn't want to have it any other way, being able to end the season with one of your biggest rivals. I know our guys will be ready to go, ready to play." Wisconsin has 22 consecutive winning seasons since going 5-7 under Barry Alvarez in 2001, the longest active streak among Power 4 teams. The Badgers also have played in a bowl game in each of the last 22 seasons, the longest active streak in the Big Ten and third-longest in FBS. Wisconsin coach Luke Fickell is more concerned with the rivalry game than the winning season and bowl streaks. "I'm not downplaying it, I'm not saying it's not important, I'm not saying it's another thing that's on our plate," Fickell said Monday. "But when it gets down to this last week, it's about one thing, it's about the rivalry. It's about preparing to play in the most important game of the year." The Gophers have dropped their last two games after winning four in a row. Minnesota averages 26.6 points per game, while allowing 18.5, 15th-best in the country. Max Brosmer has completed 67 percent of his passes for 221 per game with 15 touchdowns and five interceptions. Daniel Jackson is the top target with 69 catches for 802 yards and three scores, and Darius Taylor is the top rusher with 730 yards at 4.8 per carry with nine touchdowns. One week after leading Oregon after three quarters, the Wisconsin defense was shredded for 473 yards and five touchdowns by Nebraska. Braedyn Locke, who took over at quarterback when Tyler Van Dyke suffered an early season-ending knee injury, has thrown at least one interception in eight consecutive games. Locke has completed 56.4 percent of his passes for 180.6 yards per game, with 12 touchdowns and 10 picks. Tawee Walker is the leading rusher with 828 yards at 4.7 per carry with 10 touchdowns. He has failed to reach 60 yards in three of the last four games. Former Wisconsin and NFL standout JJ Watt posted on social media his assessment - and frustration - with the Badgers after the Nebraska game. "Losing happens, it's part of the game. Hearing announcers talk about how much tougher and more physical Nebraska & Iowa are while getting blown out ... that's the issue," Watt wrote on X. "We are Wisconsin. Physicality, running game, great O-Line and great defense. That is our identity." Wisconsin defeated the Gophers 28-14 last after Minnesota had won the previous two meetings. The Badgers have won 7 of the last 10 and lead the storied series 63-62-8. --Field Level Media