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Glufosfamide is under clinical development by Eleison Pharmaceuticals and currently in Phase III for Metastatic Adenocarcinoma of The Pancreas. According to GlobalData, Phase III drugs for Metastatic Adenocarcinoma of The Pancreas have a 38% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Glufosfamide overview Glufosfamide is under development for the treatment of metastatic pancreatic adenocarcinoma. The drug candidate is administered intravenously. Glufosfamide is beta-D-glucosyl-isophosphoramide mustard and a glucose-conjugated prodrug. It is an analogue of ifosfamide. It acts as an alkylating agent and stops tumor growth by cross-linking bases in DNA double-helix strands, directly attacking DNA. The drug candidate was also under development for the treatment of recurrent sensitive small-cell lung cancer, soft tissue sarcoma, epithelial ovarian cancer, peritoneal serous cancer, or carcinoma of the fallopian tube.It was under development for the treatment of metastatic pancreatic adenocarcinoma. Eleison Pharmaceuticals overview Eleison Pharmaceuticals is a drug development company that acquires, develops, and commercializes clinical stage drug candidates for orphan cancers. The company’s pipeline products include glufosfamide and inhaled lipid-complexed cisplatin. Its glufosfamide is an analog of chemotherapeutic agent for treatment of metabolically active tumors and hypoxic tumor regions. Eleison Pharmaceuticals’ inhaled lipid-complexed cisplatin is a sustained release formulation of cisplatin in a nanoscale lipid based complex used for pediatric osteosarcoma – bone cancer. The company provides clinical trials for pancreatic cancer and osteosarcoma. Eleison Pharmaceuticals is headquartered in Princeton, New Jersey, the US. For a complete picture of Glufosfamide’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Luke Williams feels Swansea ‘lost grip’ on game despite sealing victory at DerbyWashington: US President Joe Biden on Sunday said deposed Syrian leader Bashar Al Assad should be "held accountable" but called the nation's political upheaval a "historic opportunity" for Syrians to rebuild their country. In the first full US reaction to Assad's overthrow by an Islamist-led coalition of rebel factions, Biden expressed optimism. However, he also warned that Washington would "remain vigilant" against the emergence of terrorist groups. "The fall of the regime is a fundamental act of justice," Biden said, speaking from the White House. "It's a moment of historic opportunity for the long-suffering people of Syria." Asked by reporters what should happen to the deposed president, who reportedly has fled to Moscow, Biden said that "Assad should be held accountable." Biden, who is set to step down in January and make way for Republican Donald Trump's return to power, said Washington will assist Syrians in rebuilding. "We will engage with all Syrian groups, including within the process led by the United Nations, to establish a transition away from the Assad regime toward independent, sovereign" Syria "with a new constitution," he said. However, Biden cautioned that hardline Islamist groups within the victorious rebel alliance will be under scrutiny. "Some of the rebel groups that took down Assad have their own grim record of terrorism and human right abuses," Biden said. The United States had "taken note" of recent statements by rebels suggesting they had since moderated, he said, but cautioned: "We will assess not just their words, but their actions." Biden said Washington is "clear eyed" that the Islamic State extremist group, often known as ISIS, "will try to take advantage of any vacuum to reestablish" itself in Syria. "We will not let that happen," he said, adding that on Sunday alone, US forces had conducted "a dozen" strikes against ISIS inside Syria. Earlier, Biden met with his national security team at the White House to discuss the crisis. Assad's reported departure comes less than two weeks after the Islamist Hayat Tahrir al-Sham (HTS) group challenged more than five decades of Assad family rule with a lightning rebel offensive that broke long-frozen frontlines in the country's civil war. They announced Sunday they had taken Damascus and that Assad had fled, prompting celebrations around the country and a ransacking of Assad's luxurious home. A Kremlin source told Russian news agencies that the deposed leader was now in Moscow, along with his family. The US military has around 900 troops in Syria and 2,500 in Iraq as part of the international coalition that was established in 2014 to help combat the Islamic State jihadist group. It has regularly struck targets in the country including those linked to Iranian-backed militias. Tehran was a major backer of Assad's government. Biden also confirmed that US authorities believe the American journalist Austin Tice, who was abducted in Syria in 2012, still lives. "We believe he's alive," Biden said, but the US has yet "to identify where he is."Global stocks mostly rose Thursday following strong earnings from artificial intelligence leader Nvidia as bitcoin prices zoomed near $100,000 and oil prices rose. Nvidia itself had a volatile day, finishing modestly higher after several reversals. The chip company reported a whopping $19 billion in profits, although investors wondered if its current rate of stupendous growth is sustainable. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
Mumbai: Pakistan's secret service, the Inter-Services Intelligence (ISI), is reportedly plotting a major terror strike on India. According to sources in intelligence agencies, the ISI has studied the Israeli spy agency Mossad's use of pager bombs and is planning to have a similar operation in India. The agencies suspect that the blueprint reflects a deliberate strategy to cause maximum damage while bypassing traditional security measures. An intelligence document accessed by FPJ reveals that Pakistan-based intelligence operatives (PIOs) are actively gathering information on Indian companies in the defence sector, specially those engaged in drone component supplies. According to sources, few days ago the Central Intelligence Apparatus shared intelligence with the Ministry of Home Affairs and other sister agencies, indicating that the ISI’s covert operation mimics tactics used by Mossad, which executed the infamous "pager bomb" plot- one of the most daring and sophisticated deception operations ever against the Hezbollah. The drone strikes, similar to those modeled on the covert nature of pager bomb plot, are believed to form a part of a larger strategy by PIOs targeting high-value assets across India's political, military, and economic landscapes, a senior intelligence officer revealed, speaking on the condition of anonymity. Security agencies are taking this threat seriously, specially after a similar pager attack pattern was observed in Lebanon this September, targeting Hezbollah. On the same model, PIOs have begun scouting for drone component suppliers in South Asia, particularly in China, to establish a network capable of delivering high-tech, precision weaponry. Intelligence officials fear that, similar to how Mossad hacked into pagers and walkie-talkies to execute attacks, PIOs might tamper with key drone security components, which can later be triggered to explode whenever required, in the same manner as Mossad. As India braces for the New Year celebrations for 2025, Tourist centres are expected to be crowded, hence security has been beefed up. Several vulnerable places have been identified and are being monitored by the police through drones, including the site of the Kumbh mela where millions are expected to converge next month. They have also hired some drone agencies for the aerial recce. Officials from India's premier external intelligence agency, speaking on the condition of anonymity, described the situation as complicated, specially after alarming reports about the active terror plans of PIOs. These drone attacks could be used to target key infrastructure, defense officials, or political leaders, making them a potent weapon in the hands of terror operatives. Just like pager bombs and walkie talkie bombs, drones can be disguised as innocuous objects, making them difficult to detect until it’s too late. This new form of warfare presents a great challenge for Indian security agencies, who must adapt to the emerging threats that could be just as lethal as the traditional bombings India has faced in the past. In response, India's counter-terrorism and defense agencies have bolstered security around critical infrastructure. Moreover, Indian intelligence has ramped up surveillance on drone component suppliers and manufacturers within the region. Authorities are also collaborating with international counterparts to track drone technology sales, aiming to prevent any illegal transactions that might strengthen PIOs or other adversaries.Giants release quarterback Daniel Jones just days after benching him EAST RUTHERFORD, N.J. (AP) — The Daniel Jones era in New York is over. The Giants quarterback was granted his release by the team just days after the franchise said it was benching him in favor of third-stringer Tommy DeVito. New York president John Mara said Jones approached the team about releasing him and the club obliged. Mara added he was “disappointed” at the quick dissolution of a once-promising relationship between Jones and the team. Giants coach Brian Daboll benched Jones in favor of DeVito following a loss to the Panthers in Germany that dropped New York's record to 2-8. Conor McGregor must pay $250K to woman who says he raped her, civil jury rules LONDON (AP) — A civil jury in Ireland has awarded more than $250,000 to a woman who says she was raped by mixed martial arts fighter Conor McGregor in a Dublin hotel penthouse after a night of heavy partying. The jury on Friday awarded Nikita Hand in her lawsuit that claimed McGregor “brutally raped and battered” her in 2018. The lawsuit says the assault left her heavily bruised and suffering from post-traumatic stress disorder. McGregor testified that he never forced her to do anything and that Hand fabricated her allegations after the two had consensual sex. McGregor says he will appeal the verdict. Week 16 game between Denver Broncos and Los Angeles Chargers flexed to Thursday night spot The Los Angeles Chargers have played their way into another prime time appearance. Justin Herbert and company have had their Dec. 22 game against the Denver Broncos flexed to Thursday night, Dec. 19. Friday’s announcement makes this the first time a game has been flexed to the Thursday night spot. The league amended its policy last season where Thursday night games in Weeks 13 through 17 could be flexed with at least 28 days notice prior to the game. The matchup of AFC West division rivals bumps the game between the Cleveland Browns and Cincinnati Bengals to Sunday afternoon. NBA memo to players urges increased vigilance regarding home security following break-ins MIAMI (AP) — The NBA is urging its players to take additional precautions to secure their homes following reports of recent high-profile burglaries of dwellings owned by Milwaukee Bucks forward Bobby Portis and Kansas City Chiefs teammates Patrick Mahomes and Travis Kelce. In a memo sent to team officials, a copy of which was obtained by The Associated Press, the NBA revealed that the FBI has connected some burglaries to “transnational South American Theft Groups” that are “reportedly well-organized, sophisticated rings that incorporate advanced techniques and technologies, including pre-surveillance, drones, and signal jamming devices.” Red Bull brings wrong rear wing to Las Vegas in mistake that could stall Verstappen's title chances LAS VEGAS (AP) — Max Verstappen is suddenly in jeopardy of being denied a fourth consecutive Formula 1 title Saturday night. Red Bull apparently brought the wrong rear wing to Las Vegas and GPS data showed its two cars to be significantly slower on the straights than both McLaren and Mercedes, which led both practice sessions. Red Bull says it doesn’t have a replacement rear wing in Las Vegas to fix the issue and little chance of getting two flown in from England ahead of the race. Caitlin Clark to join Cincinnati bid for 16th National Women's Soccer League team WNBA star Caitlin Clark has joined Cincinnati’s bid for an expansion National Women’s Soccer League team. Major League Soccer franchise FC Cincinnati is heading the group vying to bring a women’s pro team to the city. The club issued a statement confirming Clark had joined the bid group. NWSL Commissioner Jessica Berman has said the league plans to announce the league’s 16th team by the end of the year. The league's 15th team will begin play in 2026 in Boston. Aaron Judge won't be bothered if Juan Soto gets bigger contract from Yankees than his $360M deal NEW YORK (AP) — Aaron Judge won’t be bothered if Juan Soto gets a bigger deal from the New York Yankees than the captain’s $360 million, nine-year contract. Speaking a day after he was a unanimous winner of his second MVP, Judge says “It ain’t my money” and adds "that’s never been something on my mind about who gets paid the most.” Judge led the major leagues with 58 homers, 144 RBIs and 133 walks while hitting .322. Soto batted .288 with 41 homers, 109 RBIs and 129 walks in his first season with the Yankees, then became a free agent at age 26. In a 'Final Four-type weekend,' two top-6 clashes put women's college basketball focus on West Coast LOS ANGELES (AP) — Two games featuring four powerhouse teams has put the focus in women's college basketball on the West Coast this weekend. JuJu Watkins and No. 3 Southern California host Hannah Hidalgo and No. 6 Notre Dame on Saturday. Top-ranked South Carolina visits Lauren Betts and fifth-ranked UCLA on Sunday. Both games are nationally televised and the arenas are expected to be packed. WNBA scouts will be on hand to check out some of the nation's top talent. Two teams will come away with their first losses of the season. USC coach Lindsay Gottlieb calls it “a Final Four-type weekend.” A documentary featuring Watkins will air on NBC ahead of USC's game, which leads into the Army-Notre Dame football game. Noodles and wine are the secret ingredients for a strange new twist in China's doping saga Blame it on the noodles. That's what one Chinese official suggested when anti-doping leaders were looking for answers for the doping scandal that cast a shadow over this year's Olympic swim meet. Earlier this year, reports that 23 Chinese swimmers had tested positive for a banned heart medication emerged. None were sanctioned because Chinese authorities determined the swimmers were contaminated by traces of the drug spread about a hotel kitchen. In a strange twist, the leader of China's anti-doping agency suggested this case could have been similar to one in which criminals were responsible for tainting noodles that were later eaten by another Chinese athlete who also tested positive for the drug. Athletes see climate change as threatening their sports and their health. Some are speaking up BAKU, Azerbaijan (AP) — Pragnya Mohan has been a professional triathlete for nearly a decade, but summers in her native India are now so hot that she can’t train there anymore. And she worries about a day when heat around the world kills her sport entirely. She was among athletes who spoke at the United Nations climate summit in Azerbaijan about the threat global warming poses to them, to fans and to sport itself. They described how extreme weather is making training and competing difficult or impossible. With billions of fans worldwide, some athletes and leagues are trying to get more people to care, and act, on climate change.
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Hackers for the Chinese government were able to deeply penetrate U.S. telecommunications infrastructure in ways that President Joe Biden’s administration hasn’t yet acknowledged, according to new reports from the Washington Post and New York Times. The hackers were able to listen to phone calls and read text messages, reportedly exploiting the system U.S. authorities use to wiretap Americans in criminal cases. The worst part? The networks are still compromised and it may take incredibly drastic measures to boot them from U.S. systems. The hackers behind the infiltration of U.S. telecom infrastructure are known to Western intelligence agencies as Salt Typhoon, and this particular breach of U.S. equipment was first reported in early October by the Wall Street Journal . But Sen. Mark Warner, a Democrat from Virginia, spoke with the Washington Post and New York Times this week to warn the public that this is so much worse than we initially thought, dubbing it “the worst telecom hack in our nation’s history.” And those articles based on Warner’s warnings were published late Thursday. Warner is chairman of the U.S. Senate Intelligence Committee and a former venture capitalist who bet big on telecom in the 1980s and 90s, making him uniquely qualified to talk about threats to U.S. communications infrastructure. And he says it’s really bad. “My hair’s on fire,” Warner told the Post. Hackers weren’t able to monitor or intercept anything encrypted, according to the Times, which means that conversations over apps like Signal and Apple’s iMessage were probably protected. But end-to-end encryption over texts between Apple devices and Android devices, for instance, aren’t encrypted in the same way, meaning they were vulnerable to interception by Salt Typhoon, according to the Times. Warner told the Post that the infiltration wasn’t directly related to the U.S. elections on Nov. 5, noting that hackers breached the system “months earlier,” and in some cases more than a year ago, though that logic is a bit confusing. If you wanted to hack a system and be prepared to gather intelligence for the election, you’d naturally want to do that well before the election. A spokesperson for Warner clarified through email Friday morning that the senator was saying this was “an espionage effort as opposed to an effort to influence the election.” As for the targets, the Post reports fewer than 150 people have been identified as having their text messages or phone calls monitored and the FBI has been in contact with them. Most of the people are in the Washington DC area, which makes sense if the hackers were interested in political targets. But 150 people can communicate with a lot of people, even in a short period, so the number of targets could be in the “millions,” according to Warner. You get the sense U.S. authorities have no real idea how many people have been impacted, given the scope of the intrusion. The details about how the hackers were able to push so deeply into U.S. systems are still scarce, but it has something to do with the ways in which U.S. authorities wiretap suspects in this country with a court order. The monitoring of phone calls wasn’t 24/7, according to Warner, but he didn’t seem to elaborate on what that meant to the Times. From the Times: All the major U.S. carriers, including AT&T, Verizon, and T-Mobile, were impacted, according to the Post. Incredibly, Warner says the hackers are still inside the U.S. system and there’s no obvious way to get them out that doesn’t involve physically replacing old equipment, according to Warner. “This is massive, and we have a particularly vulnerable system,” Warner told the Post. “Unlike some of the European countries where you might have a single telco, our networks are a hodgepodge of old networks. [...] The big networks are combinations of a whole series of acquisitions, and you have equipment out there that’s so old it’s unpatchable.” With less than two months before inauguration day, this will soon become the problem of President Donald Trump, who talks tough on China but received at least $7.8 million from the country through payments to Trump Tower in New York and Trump hotels in DC and Las Vegas, according to a report in early 2024 from the House Oversight Committee . Trump’s pick for head of the FCC, Brendan Carr, told the Post he’d received briefings on Salt Typhoon but spoke very generally about what was ahead. “Cybersecurity is going to be an incredibly important issue,” Carr said, according to the Post. “National security is going to be a top priority.”Film Certification Board: Ambitious plans, lingering challengesHow to Find Success Despite Wild Stock Market Volatility
US President Joe Biden on Sunday said deposed Syrian leader Bashar al-Assad should be "held accountable" but called the nation's political upheaval a "historic opportunity" for Syrians to rebuild their country. In the first full US reaction to Assad's overthrow by an Islamist-led coalition of rebel factions, Biden also warned that Washington will "remain vigilant" against the emergence of terrorist groups, announcing that US forces had just conducted fresh strikes against militants from the Islamic State organization. "The fall of the regime is a fundamental act of justice," Biden said, speaking from the White House. "It's a moment of historic opportunity for the long-suffering people of Syria." Asked by reporters what should happen to the deposed president, who reportedly has fled to Moscow, Biden said that "Assad should be held accountable." Biden -- set to step down in January and make way for Republican Donald Trump's return to power -- said Washington will assist Syrians in rebuilding. "We will engage with all Syrian groups, including within the process led by the United Nations, to establish a transition away from the Assad regime toward independent, sovereign" Syria "with a new constitution," he said. However, Biden cautioned that hardline Islamist groups within the victorious rebel alliance will be under scrutiny. "Some of the rebel groups that took down Assad have their own grim record of terrorism and human right abuses," Biden said. The United States had "taken note" of recent statements by rebels suggesting they had since moderated, he said, but cautioned: "We will assess not just their words, but their actions." Biden said Washington is "clear eyed" that the Islamic State extremist group, often known as ISIS, "will try to take advantage of any vacuum to reestablish" itself in Syria. "We will not let that happen," he said, adding that on Sunday alone, US forces had conducted strikes against ISIS inside Syria. The US military said the strikes were conducted by warplanes against Islamic State operatives and camps. Strikes were carried out against "over 75 targets using multiple US Air Force assets, including B-52s, F-15s, and A-10s," the US Central Command said on social media. Earlier, Biden met with his national security team at the White House to discuss the crisis. Assad's reported departure comes less than two weeks after the Islamist Hayat Tahrir al-Sham (HTS) group challenged more than five decades of Assad family rule with a lightning rebel offensive that broke long-frozen frontlines in Syria's civil war. They announced Sunday they had taken the capital Damascus and that Assad had fled, prompting celebrations nationwide and a ransacking of Assad's luxurious home. A Kremlin source told Russian news agencies that the deposed leader was now in Moscow, along with his family. The US military has around 900 troops in Syria and 2,500 in Iraq as part of the international coalition established in 2014 to help combat the Islamic State jihadist group. It has regularly struck targets in the country including those linked to Iranian-backed militias. Tehran was a major backer of Assad's government. Biden also confirmed US authorities believe the American journalist Austin Tice, who was abducted in Syria in 2012, still lives. "We believe he's alive," Biden said, but the US has yet "to identify where he is." bur-sms/mlm