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2025-01-23
Daraz announces 12.12 Grand Christmas Sale until 18 Dec.NoneOffering patients an injection is more effective than the current care of steroid tablets and cuts the need for further treatment by 30%, according to a study. Benralizumab is a monoclonal antibody that targets specific white blood cells, called eosinophils, to reduce lung inflammation. It is currently used as a repeat treatment for severe asthma at a low dose, but a new clinical trial has found that a higher single dose can be very effective if injected at the time of a flare-up. The findings, published in the Lancet Respiratory Medicine, included 158 people who needed medical attention in A&E for their asthma or COPD attack (COPD is a group of lung conditions that cause breathing difficulties). Patients were given a quick blood test to see what type of attack they were having, with those suffering an “eosinophilic exacerbation” involving eosinophils (a type of white blood cell) being suitable for treatment. Around 50% of asthma attacks are eosinophilic exacerbations, as are 30% of COPD ones, according to the scientists. The clinical trial, led by King’s College London and carried out at Oxford University Hospitals NHS Foundation Trust and Guy’s and St Thomas’ NHS Foundation Trust, saw patients randomly split into three groups. One group received the benralizumab injection and dummy tablets, another received standard care (prednisolone steroids 30mg daily for five days) and a dummy injection, and the third group received both the benralizumab injection and steroids. After 28 days, respiratory symptoms of cough, wheeze, breathlessness and sputum were found to be better in people on benralizumab. And after 90 days, there were four times fewer people in the benralizumab group who failed treatment compared with those receiving steroids. Treatment with the benralizumab injection also took longer to fail, meaning fewer visits to a GP or hospital for patients, researchers said. Furthermore, people also reported a better quality of life on the new regime. Scientists at King’s said steroids can have severe side-effects such as increasing the risk of diabetes and osteoporosis, meaning switching to benralizumab could provide huge benefits. Lead investigator Professor Mona Bafadhel, from King’s, said: “This could be a game-changer for people with asthma and COPD. “Treatment for asthma and COPD exacerbations have not changed in 50 years, despite causing 3.8 million deaths worldwide a year combined. “Benralizumab is a safe and effective drug already used to manage severe asthma. “We’ve used the drug in a different way – at the point of an exacerbation – to show that it’s more effective than steroid tablets, which is the only treatment currently available.” Researchers said benralizumab could also potentially be administered safely at home or in a GP practice, as well as in A&E. First author Dr Sanjay Ramakrishnan, clinical senior lecturer at the University of Western Australia, said: “Our study shows massive promise for asthma and COPD treatment. “COPD is the third leading cause of death worldwide but treatment for the condition is stuck in the 20th century. “We need to provide these patients with life-saving options before their time runs out.” Dr Samantha Walker, director of research and innovation at Asthma and Lung UK, welcomed the findings but said: “It’s appalling that this is the first new treatment for those suffering from asthma and COPD attacks in 50 years, indicating how desperately underfunded lung health research is.” AstraZeneca provided the drug for the study and funded the research, but had no input into trial design, delivery, analysis or interpretation.best casino sites reddit

Washington, Nov 21 (AP) While Matt Gaetzhas withdrawn from the nomination process for attorney general, President-elect Donald Trump has picked several other people for his Cabinet and key staff positions who have been accused of some form of sexual misconduct. Trump himself has long been accused of abusing or mistreating women and once was caught bragging about grabbing women by the genitals. He was found liable by a New York City jury for sexual abuse and defamation and eventually ordered to pay the woman, E. Jean Carroll, USD 83 million in damages. Taken together, there are a striking number of incidents in which potential high-ranking government officials in Trump's second administration face allegations of sexual abuse. Trump and all of his picks for government have denied the claims against them, with some of the people accused arguing the cases are driven by politics. Here's a look at what's known about the cases: President-elect Donald Trump Jurors in New York last year found Trump liable for sexually abusing Carroll, an advice columnist, in 1996. The verdict was split: Jurors rejected Carroll's claim that she was raped, finding Trump responsible for a lesser degree of sexual abuse. Jurors also found Trump liable for defaming Carroll over her allegations. Trump did not attend the civil trial and was absent when the verdict was read. Carroll was one of more than a dozen women who have accused Trump of sexual assault or harassment. She went public in a 2019 memoir with her allegation that the Republican raped her in the dressing room of a posh Manhattan department store. Trump denied it, saying he never encountered Carroll at the store and did not know her. He has called her a “nut job” who invented “a fraudulent and false story” to sell a memoir. He has similarly denied claims by other women. Pete Hegseth, nominee for secretary of defence A woman told police that she was sexually assaulted in 2017 by Hegseth after he took her phone, blocked the door to a California hotel room and refused to let her leave, according to a detailed investigative report made public this week. Hegseth told police at the time that the encounter had been consensual and denied any wrongdoing, the report said. News of the allegations surfaced last week when local officials released a brief statement confirming that a woman had accused Hegseth of sexual assault in October 2017 after he had spoken at a Republican women's event in Monterey. Hegseth's lawyer, Timothy Parlatore, said in a statement that the police report confirms “what I have said all along that the incident was fully investigated and police found the allegations to be false, which is why no charges were filed.” Parlatore said a payment was made to the woman as part of a confidential settlement a few years after the police investigation because Hegseth was concerned that she was prepared to file a lawsuit that he feared could have resulted in him being fired from Fox News, where he was a popular host. Parlatore would not reveal the amount of the payment. Robert F. Kennedy Jr., nominee for secretary of health and human services A woman who babysat for Kennedy and his second wife told Vanity Fair magazine that he groped her in the late 1990s, when she was 23. Kennedy did not deny the allegation, telling a podcast: “I had a very, very rambunctious youth.” He texted the woman an apology after the story was published. According to an interview the woman gave this week with USA Today, she said she was babysitting for his children at Kennedy's home in Mount Kisco, New York. She said that the assault happened soon after she began working there. During a kitchen table meeting with Kennedy and another person, she said she felt him rubbing her leg under the table. She told the newspaper that another time, Kennedy, then 46, asked her to rub lotion on him when he was shirtless and she obliged because she wanted to get it over with. And he grabbed her in a kitchen pantry and groped her, blocking her exit. She stayed on the job for a few more months before leaving. Linda McMahon, nominee for secretary of education A lawsuit filed last month alleges that McMahon knowingly enabled sexual exploitation of children by a World Wrestling Entertainment employee as early as the 1980s. She denies the allegations. The suit was filed in October in Maryland, where a recent law change eliminated the state's statute of limitations for child sex abuse claims, opening the doors for victims to sue regardless of their age or how much time has passed. The complaint alleges that Melvin Phillips, who died in 2012, would target young men from disadvantaged backgrounds and hire them as “ring boys” to help with the preparations for wrestling matches. Phillips would then assault them in his dressing room, hotels and even in the wrestlers' locker room, according to the complaint, which was filed on behalf of five men. The abuse detailed in the lawsuit occurred over several years during Phillips' long tenure with the organization spanning from the 1970s to the early 1990s. Because of his death, Phillips is not among the named defendants. Instead, the complaint targets WWE founders Linda McMahon and her husband Vince, who grew the organization into the powerhouse it is today. The couple was well aware of Phillips' brazen misconduct but did little to stop him, according to the complaint. “This civil lawsuit based upon thirty-plus year-old allegations is filled with scurrilous lies, exaggerations, and misrepresentations regarding Linda McMahon,” said Laura Brevetti, Linda McMahon's lawyer, in a statement. “The matter at the time was investigated by company attorneys and the FBI, which found no grounds to continue the investigation. Ms. McMahon will vigorously defend against this baseless lawsuit and without doubt ultimately succeed.” Brevetti confirmed Linda and Vince McMahon are separated. Elon Musk, Trump's choice to lead the new Department of Government Efficiency Tesla and SpaceXCEO Elon Musk was accused of sexual misconduct by a flight attendant contracted by SpaceX who worked on his private jet in 2016. He denied the claim. A 2022 report by Business Insider said SpaceX paid the woman USD 250,000 in severance in 2018 in exchange for her agreeing not to file a lawsuit over her claim. The Business Insider report was based on an account by the flight attendant's friend, who said the flight attendant told her about the incident shortly after it happened. The report also said the flight attendant was required to sign a non-disclosure agreement that prohibits her from discussing the payment or anything else about Musk and SpaceX. SpaceX didn't respond to emails seeking comment Friday. Musk responded to the allegations on Twitter, which he was in the process of buying at the time they surfaced. “And, for the record, those wild accusations are utterly untrue,” he wrote in response to one user who tweeted in support of him. He replied to another: “In my 30 year career, including the entire MeToo era, there's nothing to report, but, as soon as I say I intend to restore free speech to Twitter and vote Republican, suddenly there is ...” Matt Gaetz, who withdrew as Trump's choice for attorney general The former Florida congressman was embroiled in a sex trafficking investigation by the Justice Department he had been tapped to lead. He also was under scrutiny by the House Ethics Committee over allegations including sexual misconduct — until he resigned from Congress this week. He then withdrew his name for consideration. Gaetz has vehemently denied any wrongdoing and said last year that the Justice Department's investigation into sex trafficking allegations involving underage girls had ended with no federal charges against him. Federal investigators scrutinised a trip that Gaetz took to the Bahamas with a group of women and a doctor who donated to his campaign, and whether the women were paid or received gifts to have sex with the men, according to people familiar with the matter who were not allowed to publicly discuss the investigation. Two women House investigators that Gaetz paid them for sex and one of the women testified she saw him having sex with a 17-year-old, according to an attorney for the women. The committee began its review of Gaetz in April 2021, deferred its work in response to a Justice Department request, and renewed its work shortly after Gaetz announced that the Justice Department had ended a sex trafficking investigation. (AP) PY PY (This story has not been edited by THE WEEK and is auto-generated from PTI)

Clay scores 16, Morehead State defeats Kentucky Christian 86-63

By JUAN A. LOZANO, Associated Press HOUSTON (AP) — An elaborate parody appears to be behind an effort to resurrect Enron, the Houston-based energy company that exemplified the worst in American corporate fraud and greed after it went bankrupt in 2001. If its return is comedic, some former employees who lost everything in Enron’s collapse aren’t laughing. “It’s a pretty sick joke and it disparages the people that did work there. And why would you want to even bring it back up again?” said former Enron employee Diana Peters, who represented workers in the company’s bankruptcy proceedings. Here’s what to know about the history of Enron and the purported effort to bring it back. Once the nation’s seventh-largest company, Enron filed for bankruptcy protection on Dec. 2, 2001, after years of accounting tricks could no longer hide billions of dollars in debt or make failing ventures appear profitable. The energy company’s collapse put more than 5,000 people out of work, wiped out more than $2 billion in employee pensions and rendered $60 billion in Enron stock worthless. Its aftershocks were felt throughout the energy sector. Twenty-four Enron executives , including former CEO Jeffrey Skilling , were eventually convicted for their roles in the fraud. Enron founder Ken Lay’s convictions were vacated after he died of heart disease following his 2006 trial. On Monday — the 23rd anniversary of the bankruptcy filing — a company representing itself as Enron announced in a news release that it was relaunching as a “company dedicated to solving the global energy crisis.” It also posted a video on social media, advertised on at least one Houston billboard and a took out a full-page ad in the Houston Chronicle In the minute-long video that was full of generic corporate jargon, the company talks about “growth” and “rebirth.” It ends with the words, “We’re back. Can we talk?” Enron’s new website features a company store, where various items featuring the brand’s tilted “E” logo are for sale, including a $118 hoodie. In an email, company spokesperson Will Chabot said the new Enron was not doing any interviews yet, but that “We’ll have more to share soon.” Signs point to the comeback being a joke. In the “terms of use and conditions of sale” on the company’s website, it says “the information on the website about Enron is First Amendment protected parody, represents performance art, and is for entertainment purposes only.” Documents filed with the U.S. Patent and Trademark Office show that College Company, an Arkansas-based LLC, owns the Enron trademark. The co-founder of College Company is Connor Gaydos, who helped create a joke conspiracy theory that claims all birds are actually surveillance drones for the government. Peters said that since learning about the “relaunch” of Enron, she has spoken with several other former employees and they are also upset by it. She said the apparent stunt was “in poor taste.” “If it’s a joke, it’s rude, extremely rude. And I hope that they realize it and apologize to all of the Enron employees,” Peters said. Peters, who is 74 years old, said she is still working in information technology because “I lost everything in Enron, and so my Social Security doesn’t always take care of things I need done.” “Enron’s downfall taught us critical lessons about corporate ethics, accountability, and the consequences of unchecked ambition. Enron’s legacy was the employees in the trenches. Leave Enron buried,” she said. Follow Juan A. Lozano on X at https://x.com/juanlozano70HDMI 2.2 Set to Revolutionize Home Entertainment at CES 2025Nikita Hand, who accused the sportsman of raping her in a Dublin hotel in December 2018, won her claim against him for damages in a civil case at the High Court in the Irish capital. The jury delivered its verdict on Friday. The total amount of damages awarded to Hand by the jury was 248,603.60 euros (£206,714.31). Mr McGregor made no comment as he left court but later posted on social media that he intends to appeal. The Irish athlete has featured in multiple video games, including voice-acting a character bearing his likeness in additional downloadable content in the Hitman series. Mr McGregor’s character featured as a target for the player-controlled assassin in the game. In light of the recent court ruling regarding Conor McGregor, IO Interactive has made the decision to cease its collaboration with the athlete, effective immediately. We take this matter very seriously and cannot ignore its implications. Consequently, we will begin removing all... — HITMAN (@Hitman) November 25, 2024 IO Interactive, the Danish developer and publisher of Hitman, said in a statement: “In light of the recent court ruling regarding Conor McGregor, IO Interactive has made the decision to cease its collaboration with the athlete, effective immediately. “We take this matter very seriously and cannot ignore its implications. “Consequently, we will begin removing all content featuring Mr McGregor from our storefronts starting today.” Mr McGregor had faced an accusation that he “brutally raped and battered” Ms Hand at a hotel in south Dublin in December 2018. The Irish sports star previously told the court he had consensual sex with Ms Hand in a penthouse at the Beacon Hotel. Ms Hand was taken in an ambulance to the Rotunda Hospital the following day where she was assessed in the sexual assault treatment unit. A paramedic who examined Ms Hand the day after the assault had told the court she had not seen “someone so bruised” in a long time.

Craft scores 34, Miami (OH) takes down Bethany (WV) 112-70

49ers QB Brock Purdy resumes throwing but status for this week remains unknown

Oliver Glasner declared Crystal Palace are on the right path after they finally broke their away duck with a 1-0 win at Ipswich. Jean-Philippe Mateta struck in the second half with the only real piece of quality in a nervy encounter between two struggling teams. It is now two wins and three draws from the last six matches for Glasner’s side, whose winter revival is gathering pace nicely following a sticky start to the campaign. “I feel very happy, we’re all very pleased with the result, it was not the best performance but the result was more important,” said the Eagles boss. “Most of the time we controlled the game and we scored an amazing goal, a fantastic finish from JP. “We had more chances to decide the game but we couldn’t, but I think the win was well deserved. “We didn’t give them any chances from open play and with a clean sheet you can always take the win. “It’s a big win. Now it’s not time to sit back and relax but to keep going. In four days we face Manchester City. We stay humble. There are still many things to improve but we are on the right path.” Ipswich looked the likelier to score as a low-key first half drew to a close and were denied by a point-blank save by Dean Henderson from Harry Clarke’s near-post header. Shortly after the interval Wes Burns got clear down the right and lifted an inviting cross towards Liam Delap, whose header was straight at Henderson. However, from out of nowhere Palace conjured up a lightning counter-attack to go ahead on the hour. Eberechi Eze led the charge before feeding Mateta, who surged forward with a couple of stepovers before brushing off the attention of Jacob Greaves and finishing superbly past Arijanet Muric. It was the French forward’s sixth goal of the season, and his first away from Selhurst Park. Back came Ipswich with Leif Davis fizzing in another cross for Delap, who somehow mistimed his jump and completely missed the ball from six yards. As time ticked down Greaves looped a header against the far post, with the rebound just eluding substitute Ali-Al Hamadi. “Frustrating night,” said Town boss Kieran McKenna. “It was a tight first half, we weren’t fantastic in terms of the flow of the game and didn’t create as many opportunities as we wanted. But having said that neither did our opponents. “In the second half we conceded a really poor goal and that proved decisive. We can do better than we did tonight.”

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