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Chiefs edge Panthers, Lions rip Colts as Dallas stuns WashingtonPresident, Alliance Advisors IR Age 38 Building a business that has a strong reputation on Wall Street, all driven from my home in British Columbia. That makes me proud. The toughest business decision I faced was venturing out on my own to start my business. It meant leaving stability behind, taking significant risks and navigating a challenging market. This decision tested me more than I could have anticipated. I want my team to win together, grow together and have a rewarding, fulfilling career with us. It’s about setting the example, pushing boundaries and building an environment where everyone thrives and succeeds. The biggest lesson I’ve learned in business is that there’s no way to truly understand how resourceful you can be until you become an entrepreneur. It tests every skill and pushes you beyond your limits, revealing super powers you never knew you had. The best piece of advice I ever received was: “Iron sharpens iron. You need to be iron.” It’s a reminder to stay resilient, seek out challenges and surround myself with people who push me to grow and be stronger. Success, for me, is about creating an authentic legacy—building a strong team and disrupting an industry. It’s about leaving a meaningful impact that drives lasting change, empowers others and inspires transformation. Outside of work, I seek adventures. Whether it’s exploring new places with my family, trying new experiences or stepping outside of my comfort zone, I’m driven by curiosity and a passion for discovering the world around me. Everything. I’m on a mission to build the best IR firm in the world, and we’re just getting started. To my family: Thank you for your patience with the travel, the work calls in the car and the “one more email” moments. You are my everything. How you do anything is how you do everything We do a lot as a family to feed families in our community Listening to music is a great way to wind-down Osoyoos is my serenity Family night Keg dinners are a ritual we cherish by Anthony Pompliano—it’s my current favourite read and book to gift to others My work ethic. For me, it’s about going above and beyond—not just meeting expectations but exceeding them Samir Manji—my mentor, champion and former Forty under 40 Award recipient I was a concert review writer in high school, combining my love for music and writing

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Scheifele notches hat trick as Jets top Maple Leafs 5-2 ahead of NHL's holiday breakBiden signs defense bill despite objections to ban on transgender health care for military childrenTopline The Santa Claus stock market rally got off to a sizzling start Tuesday, as stocks leapt to their strongest Christmas Eve showing in five decades, stuffing the stockings of many investors. Key Facts Tangent There were no major economic, earnings or news catalysts Tuesday, reflected in the unusually low trading activity even for a holiday-shortened session (markets closed at 1 p.m. EST). In fact, Tuesday was the lowest volume day for the S&P since March 2, 2011, according to Yahoo Finance data. What Is The Santa Claus Rally? The term refers to the phenomenon of better-than-average stock market returns over the final five trading days of a year and first two sessions of the following year. Since 1950, the S&P has gained 1.3% on average over that seven-session period, far outstripping the 0.3% average advance over a typical seven-day stretch, according to LPL Financial research. This year’s Santa Claus rally lasts from Tuesday to next Friday. Surprising Fact It’s been a December to remember for stock market historians. Earlier this month, the Dow Jones Industrial Average suffered its longest losing streak in 50 years, falling for 11 consecutive trading sessions. The Dow, which tracks 30 American companies, has gained more than 2% since breaking the losing streak last week. Further Reading

December 23, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Michael Pearson, Georgia Institute of Technology When it comes to finding solutions to climate change, there's no shortage of technologies vying for attention, from renewable energy to electric vehicles to nuclear energy. One such contender, solar geoengineering, is favored by proponents who say it could quickly cool the planet and give the world time to fully implement efforts to limit emissions and remove carbon from the atmosphere. But that promise comes with risks, which include potentially poorer air quality or depleted atmospheric ozone—both of which can cause serious health issues of their own. A new Georgia Tech School of Public Policy-led study published in the Proceedings of the National Academy of Sciences suggests that while those risks deserve further consideration, solar geoengineering could save as many as 400,000 lives a year through a reduction in temperature-related deaths attributable to climate change . "An important question is how the reduction in climate risks from solar geoengineering compares to the additional risks its use entails," said lead author Anthony Harding of the School of Public Policy. "This study offers a first step in quantifying the risks and benefits of solar geoengineering and shows that, for the risks we considered, the potential to save lives outweighs the direct risks," Harding co-authored the PNAS article with Gabriel Vecchi and Wenchang Yang of Princeton University and David Keith from the University of Chicago. The researchers studied a climate change mitigation strategy called stratospheric aerosol injection (SAI), a type of solar geoengineering that involves spraying tiny reflective particles into the upper atmosphere. Those particles would then redirect some sunlight back to space and help cool Earth. The authors used computer models and historical data on how temperature affects death rates to see how much solar geoengineering might affect death rates , assuming a 2.5-degree Celsius increase in average temperature from pre-industrial levels and similar approaches to climate change as seen in the world currently. They found that cooling global temperatures by 1 degree Celsius with solar geoengineering would save 400,000 lives each year, outweighing deaths caused by solar geoengineering's direct health risks from air pollution and ozone depletion by a factor of 13. This means that the number of lives saved due to solar geoengineering-caused cooling would be 13 times the number of lives potentially lost from solar geoengineering's known risks. Many of those deaths would be avoided in hotter, poorer regions, the study notes. Cooler, wealthier regions could actually face increased cold-related deaths. Solar geoengineering has generated millions of dollars in funding and a recommendation by the National Academies of Science that the federal government should provide millions more toward research and the development of a risk-risk analysis similar to what Harding's team produced. But the tech has also drawn concern, including from the Union of Concerned Scientists. That group says there's too much environmental, ethical, and geopolitical risk to proceed without much more research. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . The authors caution that their study is an important starting point in better understanding solar geoengineering's promise and peril but is far from a comprehensive evaluation of the technology's risks and benefits. They say their models are based on idealized assumptions about aerosol distribution, population and income growth, and other factors. They also can't capture all of the real-world complexities that solar geoengineering would entail. They note their study also does not address all of the potential risks of solar geoengineering, such as possible impacts on ecosystems, global politics, or the possibility governments will rely on the technology to delay politically difficult emissions cuts. Still, the researchers say, the study suggests that for many regions, solar geoengineering could well be more effective at saving lives than emissions reductions alone and is worth keeping in the mix as the world searches for the optimal ways to cool our warming planet. "There's no perfect resolution to the climate crisis," said Harding. "Solar geoengineering entails risks, but it could also alleviate real suffering, so we need to better understand how the risks compare to the benefits to inform any potential future decisions around the technology." More information: Anthony Harding et al, Impact of solar geoengineering on temperature-attributable mortality, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2401801121 Journal information: Proceedings of the National Academy of Sciences Provided by Georgia Institute of Technology

Unai Emery felt his Aston Villa side restored confidence by returning to winning ways with a 3-1 victory over Brentford in the Premier League. Morgan Rogers’ fourth goal of the season, an Ollie Watkins penalty and Matty Cash’s finish put Villa 3-0 up after 34 minutes. Mikkel Damsgaard pulled one back for Brentford in the second half but the damage had been done as Villa ended their eight-match winless run in all competitions. Emery was relieved to end the unwanted streak but quickly turned his attention to the next fixture against Southampton on Saturday. “We broke a spell of bad results we were having,” the Villa boss said. “We started the first five or 10 minutes not in control of the game but then progressively we controlled. “Today we achieved those three points and it has given us confidence again but even like that it’s not enough. We have to keep going and think about the next match against Southampton on Saturday. “The message was try to focus on each match, try to forget the table. How we can recover confidence and feel comfortable at home. Today was a fantastic match.” Tyrone Mings returned to the starting line-up in the Premier League for the first time since August 2023. Emery admitted it has been a long road back for the 31-year-old and is pleased to have him back. He added: “Mings played in the Champions league but it’s the first time in the league for a year and three months. “I think he played fantastic – he might be tired tomorrow but will be ready for Saturday again. “It was very, very long, the injury he had. His comeback is fantastic for him and everybody, for the doctor and physio and now he’s training everyday.” Brentford fell to a sixth away defeat from seven games and have picked up only a solitary point on the road this season. They have the best home record in the league, with 19 points from seven matches, but they have the joint worst away record. Bees boss Thomas Frank is confident form will improve on the road. He said: “On numbers we can’t argue we are better at home than away, but on numbers it’s a coincidence. I think two of the seven away games have been bad. “The other games we performed well in big spells. I’m confident at the end of the season we will have some wins away from home.” Frank felt Villa should not have been given a penalty when Ethan Pinnock brought Watkins down. He added: “I want to argue the penalty. I don’t think it is (one). I think Ollie kicked back and hit Ethan, yes there is an arm on the shoulder but threshold and all that – but that’s not the reason we lost.”Pakistani police arrest thousands of Imran Khan supporters ahead of rally in the capital

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NoneDec 16, 2024 Researchers create microchips capable of detecting and diagnosing diseases ( Nanowerk News ) In a world grappling with a multitude of health threats — ranging from fast-spreading viruses to chronic diseases and drug-resistant bacteria — the need for quick, reliable, and easy-to-use home diagnostic tests has never been greater. Imagine a future where these tests can be done anywhere, by anyone, using a device as small and portable as your smartwatch. To do that, you need microchips capable of detecting miniscule concentrations of viruses or bacteria in the air. Now, new research from NYU Tandon faculty including Professor of Electrical and Computer Engineering Davood Shahrjerdi; Herman F. Mark Professor in Chemical and Biomolecular Engineering Elisa Riedo; and Giuseppe de Peppo, Industry Associate Professor in Chemical and Biomolecular Engineering and who was previously at Mirimus, shows it’s possible to develop and build microchips that can not only identify multiple diseases from a single cough or air sample, but can also be produced at scale. “This study opens new horizons in the field of biosensing. Microchips, the backbone of smartphones, computers, and other smart devices, have transformed the way people communicate, entertain, and work. Similarly, today, our technology will allow microchips to revolutionize healthcare, from medical diagnostics, to environmental health” says Riedo, “The innovative technology demonstrated in this article uses field-effect transistors (FETs) — miniature electronic sensors that directly detect biological markers and convert them into digital signals — offering an alternative to traditional color-based chemical diagnostic tests like home pregnancy tests,” said Shahrjerdi. “This advanced approach enables faster results, testing for multiple diseases simultaneously, and immediate data transmission to healthcare providers” says Sharjerdi, who is also the Director of the NYU Nanofabrication Cleanroom, a state-of-the-art facility where some of the chips used in this study were fabricated. Riedo and Shahrjerdi are also the co-directors of the NYU NanoBioX initiative. Field-effect transistors, a staple of modern electronics, are emerging as powerful tools in this quest for diagnostic instruments. These tiny devices can be adapted to function as biosensors, detecting specific pathogens or biomarkers in real time, without the need for chemical labels or lengthy lab procedures. By converting biological interactions into measurable electrical signals, FET-based biosensors offer a rapid and versatile platform for diagnostics. Recent advancements have pushed the detection capabilities of FET biosensors to incredibly small levels — down to femtomolar concentrations, or one quadrillionth of a mole — by incorporating nanoscale materials such as nanowires, indium oxide, and graphene. Yet, despite their potential, FET-based sensors still face a significant challenge: they struggle to detect multiple pathogens or biomarkers simultaneously on the same chip. Current methods for customizing these sensors, such as drop-casting bioreceptors like antibodies onto the FET’s surface, lack the precision and scalability required for more complex diagnostic tasks. To address this, these researchers are exploring new ways to modify FET surfaces, allowing each transistor on a chip to be tailored to detect a different biomarker. This would enable parallel detection of multiple pathogens. Enter thermal scanning probe lithography (tSPL), a breakthrough technology that may hold the key to overcoming these barriers. This technique allows for the precise chemical patterning of a polymer-coated chip, enabling the functionalization of individual FETs with different bioreceptors, such as antibodies or aptamers, at resolutions as fine as 20 nanometers. This is on par with the tiny size of transistors in today’s advanced semiconductor chips. By allowing for highly selective modification of each transistor, this method opens the door to the development of FET-based sensors that can detect a wide variety of pathogens on a single chip, with unparalleled sensitivity. Riedo, who was instrumental in the development and proliferation of tSPL technology, sees its use here to be further evidence of the groundbreaking way this nanofabrication technique can be used in practical applications. “tSPL, now a commercially available lithographic technology, has been key to functionalize each FET with different bio-receptors in order to achieve multiplexing,” she says. In tests, FET sensors functionalized using tSPL have shown remarkable performance, detecting as few as 3 attomolar (aM) concentrations of SARS-CoV-2 spike proteins and as little as 10 live virus particles per milliliter, while effectively distinguishing between different types of viruses, including influenza A. The ability to reliably detect such minute quantities of pathogens with high specificity is a critical step toward creating portable diagnostic devices that could one day be used in a variety of settings, from hospitals to homes. The study, now published by the Royal Society of Chemistry in Nanoscale ( "Nanoscale-localized multiplexed biological activation of field effect transistors for biosensing applications" ), was supported by Mirimus, a Brooklyn-based biotechnology company, and LendLease, a multinational construction and real estate company based in Australia. They are working with the NYU Tandon team to develop illness-detecting wearables and home devices, respectively. “This research shows off the power of the collaboration between industry and academia, and how it can change the face of modern medicine,” says Prem Premsrirut, President and CEO of Mirimus. “NYU Tandon’s researchers are producing work that will play a large role in the future of disease detection.” “Companies such as Lendlease and other developers involved in urban regeneration are searching for innovative solutions like this to sense biological threats in buildings.” says Alberto Sangiovanni Vincentelli of UC Berkeley, a collaborator on the Project. “Biodefense measures like this will be a new infrastructural layer for the buildings of the future” As semiconductor manufacturing continues to advance, integrating billions of nanoscale FETs onto microchips, the potential for using these chips in biosensing applications is becoming increasingly feasible. A universal, scalable method for functionalizing FET surfaces at nanoscale precision would enable the creation of sophisticated diagnostic tools, capable of detecting multiple diseases in real time, with the kind of speed and accuracy that could transform modern medicine. Source: NYU Tandon School of Engineering (Note: Content may be edited for style and length)

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It is truly a headline many Calgary Flames fans thought they may never see. Left winger Jonathan Huberdeau has been tremendously disappointing ever since he was acquired from the Florida Panthers back in the summer of 2022. As the centrepiece of a trade package for young All-Star Matthew Tkachuk and a former 115 point scorer himself, Huberdeau had immense pressure to perform. Playing for a Canadian market and signing a franchise record 8-year, $84 million contract drove expectations up even further. In his first season in Cowtown, Huberdeau put up just 15 goals and 40 assists in 79 games to set an NHL record for the largest season-to-season point drop off ever recorded. Many pointed the finger at then-head-coach Darryl Sutter, whom Huberdeau and other veterans clashed with frequently. Some stated that the move across the continent and overall adjustment to life in the Great White North was the culprit. However, with a new head coach and more social stability in 2023-24, he scored only 12 times and had 52 points in 81 games, along with a career-worst minus-29 rating. Many fans and media personalities were quick to point out that Huberdeau’s 2023-24 was a tale of two seasons; in the first 41 games he scored six goals and 21 points but heated up to the tune of six goals and 31 points in the following 40 contests. Now 34 games into the 2024-25 season it seems as though “Huby” has built upon this pace as he currently leads the Flames with 13 goals and 25 points. His hot start is more than worthy of a closer look. A December to Remember Much of Huberdeau’s success has come due to an impressive recent stretch of play. From Nov. 30 until the time of writing (10 games), he has rippled the twine six times and added seven helpers for 13 points. After two-and-a-half seasons of trying, he has finally found chemistry with fellow 2022 acquisition Nazem Kadri , who has six goals and nine points in the same span. Huberdeau’s six-game point streak from Nov. 30 until Dec. 12 is tied for the best mark of his Flames tenure. Over the past summer, the French-Canadian forward stated that he had been working intensely on his shot, which has seemingly paid off in full. As a career playmaker, Huberdeau characteristically elects to distribute the puck rather than put it on net. He now has more confidence shooting and during this same hot streak has accumulated 23 shots on goal. His higher volume has contributed to more success; he is shooting at a career-best 21.7% clip. With his tally on Dec. 21 against the Chicago Blackhawks, Huberdeau registered his 13th goal of the season, already surpassing the 12 he had in all of 2023-24. The team has been iffy during the past 10 games, but still captured 11 out of a possible 20 points with a 4-3-3 record. Over this period, the team has scored 29 goals for a rate of 2.9 per contest, meaning Huberdeau has factored into approximately 45% of his team’s offence during his streak. For comparison, the only Flames to register more than five points during this time are Kadri, Connor Zary , and Matt Coronato. Any time Huberdeau is on the ice this season, the Flames control the puck; he has registered a 56% Corsi For rating, which means the Flames have more shot attempts than their opponents. There are even defensive improvements as the winger is on pace for a career-high 68 blocked shots. Is Huberdeau Officially Back? Now, is this type of Huberdeau one that Flames fans should get used to? Not yet. This is a very impressive stretch of hockey even beyond the past 10 games. In total over his past 74 appearances, Huberdeau has 19 goals and 56 points. He is currently on pace to finish the 2024-25 campaign with 31 goals and 60 points, which would both shatter his previous highest Flames totals. Huberdeau hasn’t reached the 30-goal plateau since the 2021-22 season, his last with the Panthers. It is something the pass-first forward has also only done twice in his career. However, the second half of this season should once and for all determine what Huberdeau can bring to the table moving forward. Fans should prepare for regression. It is important to note a few things in helping determine the sustainability of Huberdeau’s recent play. First of all, his aforementioned 21.7% shooting success rate is likely not something he can maintain for the next 48 games. He is also playing more than ever before as a Flame, with an 18:30 average time on ice. Should the team’s performance start to decline, head coach Ryan Huska will probably play the younger forwards more often, which would eat into Huberdeau’s ice time. In addition, his line mate Kadri’s name has come up in trade talks and his movement could disrupt Huberdeau’s performance. If Huberdeau can navigate through all of these challenges and the others every season brings and keep on producing, his identity as a Flame will become more concrete. All in all, Huberdeau has been showing glimpses of the player the Flames thought they were getting back in 2022. If he can sustain his recent play, he will offer more hope to the many fans that have always believed in him as an on-ice contributor. While 60 points a season may not be worth $10.5 million, it is certainly an improvement on the production thus far and a step in the right direction for both team and player. At the end of the day, the Flames are relatively competitive and Huberdeau is currently leading the team in scoring. Things are good in Cowtown for the moment. This article first appeared on The Hockey Writers and was syndicated with permission.Samsung’s The Premiere 8K Display Becomes the World’s First Certified 8K ProjectorThe Gunners took two points out of Liverpool’s lead at the summit of the Premier League after Jurrien Timber and William Saliba struck in the second half – both from corners – to condemn Amorim to his first defeat as United boss. The hosts’ second-half strikes took their goals-from-corners tally to 22 since the start of last season – a statistic that is unmatched by any other team in the division. Asked if Arsenal are one of the best teams he has come up against on corners, Amorim replied: “If you follow the Premier League for a long time you can see that. “They are also big players and you see every occasion when (Gabriel) Martinelli and (Bukayo) Saka have one-on-ones, a lot of times they go outside and they cross, and they know that if the cross goes well, they can score, and if it is a corner they can score, too, so we have to be better on that. “You have seen in all Arsenal games that every team have had problems with that (corners). And the difference today was the set-pieces. “You see a goal and then the momentum changed, and it is really hard for us to take the full control of the game after that.” Timber leaned into Rasmus Hojlund at the front post before diverting Declan Rice’s set-piece into the back of Andre Onana’s net after 54 minutes to send Arsenal into the lead. Thomas Partey’s header from Saka’s corner then deflected in off Saliba’s shoulder with 17 minutes left. Arteta and the club’s set-piece guru Nicolas Jover embraced on the touchline as Amorim was left with his head in his hands. The Arsenal supporters cheered raucously every time they won a corner – landing 13 in all without reply. However, Arteta moved to play down the significance of Arsenal’s set-piece threat. “We need that, but we want to be very dangerous and very effective from every angle and every phase of play,” said Arteta. “Today we could have scored from open play like we did against West Ham and Sporting. Last year we scored the most goals in the history of this football club. Arsenal have won four consecutive Premier League matches against Man Utd for the first time ever! 💫 pic.twitter.com/biv1kvsJEP — Premier League (@premierleague) December 4, 2024 “Not because of only set-pieces, but because of a lot of things that we have. We want to create individual and magic moments, too.” Arsenal’s win against United – the first time they have recorded four victories in a row against the Red Devils in the league – was their fourth in succession since the international break. They will head to Fulham on Sunday bidding to keep the momentum going. Arteta continued: “The will to win is there. We try our best to do that. We won four in a row, but it doesn’t matter. We have to go to Fulham now, try to be better than them and try win the game. “It’s every three days that we play. It’s a crazy schedule. We’re going to need everybody and to mentally be very strong.”

That Time Robert Pattinson Was Accused Of Quitting Acting Years After Twilight And Provided A Funny Two-Word ResponsePORT-AU-PRINCE, Haiti (AP) — Two reporters were killed and several were wounded Tuesday in a gang attack in Haiti on the reopening of Port-au-Prince’s biggest public hospital, Haiti’s online media association said. A police officer was also killed in the attack. Street gangs forced the closure of the General Hospital early this year and authorities had pledged to reopen the facility in Haiti’s capital on Christmas Eve. But as journalists gathered to cover the event, suspected gang members opened fire. Robest Dimanche, a spokesman for the Online Media Collective, identified the killed journalists as Markenzy Nathoux and Jimmy Jean. Dimanche said an unspecified number of reporters were also been in the attack, which he blamed on the Viv Ansanm coalition of gangs. The Haitian Association of Journalists confirmed two reporters and a police officer were killed, and seven reporters were wounded in what it called “a macabre scene comparable to terrorism, pure and simple.” Haiti’s interim president, Leslie Voltaire, said in an address to the nation that journalists and police were among the victims of the attack. He did not specify the casualty numbers or provide a breakdown. “I send my sympathies to the people who were victims, the national police and the journalists,” Voltaire said. Later, the government put out a statement saying it is “responding firmly to the attack.” “This heinous act, which targets an institution dedicated to health and life, constitutes an unacceptable attack on the very foundations of our society,” it said. Earlier, a video posted online by the reporters trapped inside the hospital shows what appeared to be two lifeless bodies of men on stretchers, their clothes bloodied. One of the men had a lanyard with a press credential around his neck. Radio Télé Métronome initially reported that seven journalists and two police officers were wounded. Police and officials did not immediately respond to calls for information on the attack. Another video posted online, which also could not be immediately verified, showed reporters inside the building and at least three lying on the floor, apparently wounded. Street gangs have taken over an estimated 85% of Port-au-Prince and have also targeted the main international airport and Haiti’s two largest prisons. Johnson “Izo” André, considered Haiti’s most powerful gang leader and part of the Viv Ansanm group of gangs, which that has taken control of much of Port-au-Prince , posted a video on social media claiming responsibility for the attack. The video said the gang coalition had not authorized the hospital’s reopening. Haiti has seen journalists targeted before. In 2023, two local journalists were killed in the space of a couple of weeks — radio reporter Dumesky Kersaint was fatally shot in mid-April that year, while journalist Ricot Jean was found dead later that month. In July, former Prime Minister Garry Conille visited the Hospital of the State University of Haiti, more widely known as the General Hospital, after authorities regained control of it from gangs. The hospital had been left ravaged and strewn with debris. Walls and nearby buildings were riddled with bullet holes, signaling fights between police and gangs. The hospital is across the street from the national palace, the scene of several battles in recent months. Gang attacks have pushed Haiti’s health system to the brink of collapse with looting, setting fires, and destroying medical institutions and pharmacies in the capital. The violence has created a surge in patients and a shortage of resources to treat them. Haiti’s health care system faces additional challenges during the rainy season, which is likely to increase the risk of water-borne diseases. Poor conditions in camps and makeshift settlements have heightened the risk of diseases like cholera, with over 84,000 suspected cases in the country, according to UNICEF. ___ Follow AP’s coverage of Latin America and the Caribbean at https://apnews.com/hub/latin-americaConnor Clark & Lunn Investment Management Ltd. Boosts Stake in Castle Biosciences, Inc. (NASDAQ:CSTL)

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