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NoneNoneLesabelimab is under clinical development by Dragonboat Biopharmaceutical (Shanghai) and currently in Phase I for Endometrial Cancer. According to GlobalData, Phase I drugs for Endometrial Cancer have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Lesabelimab overview lesabelimab is under development for the treatment of advanced malignant tumors including invasive bladder cancer, head and neck squamous cell carcinoma, esophageal squamous cell carcinoma and penile squamous cell carcinoma, endometrial cancer, cervical cancer, ovarian cancer, colorectal cancer, advanced non-clear cell renal cancer and advanced penile cancer, and unspecified indication. It acts by targeting PD L1. The drug candidate is administered as injection. lesabelimab is under development for the treatment of nasopharyngeal carcinoma and solid tumors. Dragonboat Biopharmaceutical (Shanghai) overview Dragonboat Biopharmaceutical (Shanghai) (Dragonboat Biopharmaceutical), a subsidiary of Guilin Sanjin Pharmaceutical Co Ltd, is a biopharmaceutical company that researches and develops biologics for cancers and autoimmune diseases. The company pipeline product includes BC003, BC001, BC005, BC006, BC007, BC008, BC010, BC011 and BCT2101. Dragonboat Biopharmaceutical drug candidate indications include solid tumors, tenosynovial giant cell tumors, asthma, gastric cancer and pancreatic cancer among others. It also utilizes an In-house systemic platform. The company operates a drug research and development center that covers early discovery, preclinical research, IND, clinical research, biologics license application and manufacturing. Dragonboat Biopharmaceutical is headquartered in Shanghai, China. For a complete picture of Lesabelimab’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
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Zifa Normalisation Committee chairman Lincoln Mutasa says they are on course for the eagerly awaited Zifa elections after unveiling the road map in Harare on Monday. The elective congress, which is the last item on the Fifa-appointed committe’s bucket list, will mark the end of its mandate on January 25, 2025. Addressing a press conference in Harare, Mutasa, who was flanked by Normalisation Committee members Rosemary Mugadza and lawyer Nyasha Sanyamandwe, said they have achieved results on the six points in their revised mandate. “We have put a roadmap for the upcoming elective congress, which will be held in January. As the NC, we had six points to fulfill,” he said. “We have covered most of them, that is running the affairs of Zifa, restructuring the secretariat, review of the Zifa statutes. We also signed an MOU with the SRC, which is a collaborative agreement where we sort of agreed with them on the modus operandi and areas of cooperation, in particular paying attention to the issue of sexual harassment. “Another part of the mandate was the hand-over of the audited finances to the incoming executive committee. “At the AGM we had last month, we managed to get the 2021 and 2022 audited accounts handed over and we are hoping that by the time of the elective congress, we would have the 2023 audited accounts completed, as well as the 2024 accounts put together. “Our final mandate was to act as the electoral committee to conduct the elections for the incoming Zifa executive committee. This we feel is an important role and an important milestone towards bringing our football back to normalcy,” said Mutasa. Source: Herald
After absorbing their worst defeat of the year , the San Jose Sharks will be looking for a response Saturday against the Florida Panthers. The Sharks reverted to some bad habits during their 8-1 loss to the Tampa Bay Lightning on Thursday, as they strayed from their identity and were generally outworked from start to finish. The seven-goal loss was the Sharks’ most lopsided of the season, unceremoniously ending a three-game winning streak. While the Sharks have been playing better hockey l ately, the loss in Tampa offered a blunt reminder that they can still get embarrassed when their details and competitive level are not where they need to be, particularly against playoff-caliber teams. “Break out pucks, defend hard, box out, you name it,” Sharks coach Ryan Warsofsky told reporters when asked about the defense’s shortcomings. “What a defenseman’s responsibilities are, we could have done a lot better.” The forward group wasn’t let off the hook, either. “Didn’t pay a price,” Warsofsky said. “You watch (the Lightning), they’re blocking shots. (Mikey) Eyssimont), (Luke) Glendining (when it’s) 8-1. And that’s the price to pay to win games in this league and that’s what we’ve got to learn.” The Sharks have done a fairly good job this season of responding after blowout defeats. After an 8-3 road loss to the Winnipeg Jets on Oct. 18, they returned home and played a much more competitive game two days later against the Colorado Avalanche in a 4-1 loss. Two days after getting blown out 7-3 by the Vegas Golden Knights on Oct. 26, the Sharks erased a three-goal deficit in the final five minutes of the third period against the Utah Hockey Club and won 5-4 in overtime. Now the Sharks face the reigning Stanley Cup champion Panthers, who, before Friday, were the third-highest scoring team in the NHL at 3.78 goals per game. Florida entered Friday tied for first place in the Atlantic Division with the Toronto Maple Leafs. “I’m not deflated. It’s an 82-game season,” Sharks defenseman Mario Ferraro said after Thursday’s loss. “We’ve got another game in a couple of days and another opportunity to play a really good hockey team and surprise them. So it’s not deflating, but it’s definitely not something that’s acceptable, so we’ve got to be better.” The Sharks have lost 10 straight games to the Panthers, with their last victory in South Florida coming on Dec.1, 2017. The Sharks might have to face the Panthers without rookie forward Will Smith, who did not practice Friday. Warsofsky told San Jose Hockey Now that Smith is day-to-day with an upper-body injury, although it remained unclear when the 19-year-old was injured. Against the Lightning, Smith played late into the third period and finished with 15:50 in ice time. Smith has 11 points in 23 games this season and has recently been playing on a line with Mikael Granlund and Klim Kostin. Regardless of who plays against the Panthers, the Sharks still need to prove that they can consistently produce a strong performance against quality opponents. “We’ll obviously take a look at everything and talk within the group and figure it out,” Sharks winger Luke Kunin said, “so it doesn’t happen again.” GOODROW RETURNS: Forward Barclay Goodrow, who has been on injured reserve since Nov. 28 with an upper-body ailment, skated Friday, per San Jose Hockey Now. Goodrow was injured by a high hit from Ridly Greig in the Sharks’ Nov. 27 game against the Ottawa Senators. He is questionable to play against the Panthers. TEDDY BEAR TOSS: The San Jose Barracuda are hosting its annual Teddy Bear Toss at Tech CU Arena on Saturday when it plays the Coachella Valley Firebirds at 6 p.m. Fans are urged to bring stuffed animals to the game and throw them on the ice after the Barracuda scores its first goal. The Barracuda will then distribute some of the stuffed animals to children at local Kaiser Permanente hospitals, as well as other kids who might not get a gift during this time of year. The AHL franchise is also joining forces with San Jose-based Working Partnerships USA, which, per the team, helps to tackle “the root causes of inequality and poverty by leading collaborative campaigns for quality jobs, healthy communities, equitable growth, and a vibrant democracy.” For Saturday’s game, the Barracuda will also wear specialty jerseys that will be auctioned off after the game, with part of the proceeds going to Working Partnerships. The team is also giving away Barracuda stockings to the first 1,500 fans in the building.Rimini Street Announces New Management Console for Rimini ConnectTM Suite of Interoperability Solutions
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AP Sports SummaryBrief at 6:11 p.m. ESTAfter Trump’s win, Black women are rethinking their role as America’s reliable political organizers