
Travelling on a budget in winter has been challenging and as many of you may know, it is almost impossible to fit all the thick sweaters and jacket in one under-seat bag. As a fashion writer, I gave myself a mission to look for a winter coat that keeps me warm in the Baltic while keeping my outfit alpine-chic during my weekend trip in Vilnius, Lithuania. To keep my luggage as light as possible, I opted for lululemon's Wunder Puff Cropped Jacket in Textured Fleece , £228, and I will explain why it's perfect for a trip and cold weather. There's a limitation in planning outfits when you ideally want to have different looks. The lululemon Wunder Puff Jacket has been a fan favourite for years and the textured fleece is a new addition this year. I'd normally go for a classic black but for winter, I think the bone colour brightens my complexion and it fits well into the theme of "dreaming of a white Christmas ". READ MORE: Oddbox offers £8 veg boxes as a savvy alternative to Lidl for Christmas dinner READ MORE: Kayali's new perfume causes a stir with its irresistible marshmallow scent The cropped length is better for movement as I planned to hike up the Hill of Three Crosses in Kalnai Park, Lithuania, and I could show more of my outfit under the coat compared to a full length coat. The Wunder Puff Jacket is more than a puffer jacket, its 550-fill-power goose down is a high quality down insulation that stops my body shivering in the cold. I was wearing thin tops underneath my jacket and walking in -7°C weather was absolutely fine, except my hands were feeling cold. Luckily, I had a 2-in-1 power bank that doubled as a hand warmer , which costs £29.99 on Amazon. The lululemon jacket is also made for wind and water protection and I could swap between styles should I want to remove the hood . With the hood, it blocked the wind out and kept my ears warm but it's a more sporty and I looked like an urban explorer. Personally I preferred the "hood off" look - it's more versatile in terms of matching outfits and the high neck opening protected my neck against all wind, rain and cold. Not only did I not have to bring a scarf with me, I also ditched my handbag because the jacket comes with two zipped hand pockets and two extra interior pockets (perfect for cards and keys). For the price of £228, it's expensive for outerwear. However, I see it as an investment because I know I will make the most wear out of it and textured fleece is always a winter staple - it's cosy, puffy and warm. But one shopper decided to return the coat as she shared: "Very cute and warm, however I returned it because it’s quite heavy, and looks like it’s easy to get dirty." The lovely bone colour is selling fast and there's only UK4 left (which in my opinion, can comfortably fit for UK6) but all sizes are in stock if you want to choose the black colour - you can shop lululemon Wunder Puff Cropped Jacket in Textured Fleece here . A longer version is available in more colours and has a length that covers the bum and it's £20 more than the cropped version . Alternatively Columbia's Bulo Point III Hooded Down Puffer Jacket , £270, is also an excellent cropped winter jacket and instead of down insulation, it incorported NASA-inspired technology and created a gold panel called Omni-Heat technology that traps heat in the cold. If that's out of your budget, Uniqlo has a similar style for less. The Seamless Stlye Short Jacket has a count of over 750 fill power and a 'superior water-repellent functionality' and it retails for £109.90 but it doesn't come with a hood.10 budget-friendly Christmas gifts for employeesATLANTIC CITY, N.J. (AP) — New Jersey gambling regulators have handed out $40,000 in fines to two sportsbooks and a tech company for violations that included taking bets on unauthorized events, and on games that had already ended. In information made public Monday, the New Jersey Division of Gaming Enforcement fined DraftKings $20,000. It also levied $10,000 fines on Rush Street Interactive NJ and the sports betting technology company Kambi. According to documents released by the state, Rush Street accepted 16 bets worth $1,523 in Nov. 2021 on a college basketball game between the University of North Carolina-Asheville and Tennessee Tech University after the game had already concluded with a UNC victory. Kambi told the enforcement division that a trader had failed to manually remove that game from its betting markets, saying it had stopped receiving messages from its own sports data provider due to a network connectivity error. Kambi said it has updated its guidelines and retrained its traders to prevent a recurrence. Kambi, which is based in Malta, did not immediately respond to a message seeking comment Monday. Rush Street declined comment, and DraftKings had no immediate comment Monday. DraftKings stopped using Kambi in 2021. In March 2022 Rush Street took seven bets totaling just under $2,900 on three Magic City Jai Alai games after the results were already known. Kambi told the division it experienced a connectivity issue that allowed the bets to be accepted after the games were over. An explanation of what Kambi did to address the situation was blacked out in documents released by the division. A month earlier Rush Street took 13 wagers worth $8,150 with pre-match odds on a Professional Golf Association match after the event had already begun. In this case, Kambi told the division a newly hired trader failed to enter the correct closing time time for bets on the event. The trader and a supervisor underwent retraining. DraftKings was fined for taking bets on unapproved events including Russian basketball for nine months in 2020 and 2021. It eventually voided over $61,000 in bets and returned the money to customers after being directed to do so by the state. In this case, Kambi told the division it misidentified this particular Russian basketball league as one that was approved for wagering in New Jersey. DraftKings told the state it did not catch the error, either. In 2020, DraftKings accepted 484 wagers on unapproved table tennis matches. Kambi incorrectly enabled the events for wagering without conditions required by the state, the division said. In Feb. 2022, the division said DraftKings took pre-season NFL bets involving specific players but did not give the state specific information on what information was to be included in the bets, drawing 182 wagers worth nearly $7,000 that were later voided and refunded to customers. Follow Wayne Parry on X at www.twitter.com/WayneParryACGophers senior linebacker Cody Lindenberg has declined to use his final season of eligibility in 2025 and instead declared for the NFL draft on Friday. Lindenberg was healthy and highly productive in 2024, leading Minnesota with 94 total tackles as well as one sack and one interception in all 12 games. The Anoka native overcame injuries in both 2023 and ’21 to be an all-Big Ten selection this fall. “Every single day for the past five seasons has been a dream come true playing for and in front of you all in the maroon and gold!” Lindenberg wrote on social media. “Representing this university, this program and this state means more to me than anyone will ever know.” With Lindenberg leaving, the need to add a linebacker via the NCAA transfer portal grows more important. They have yet to add a linebacker among the 11 new additions for next season.
Article content ‘Tis the season to start shopping for loved ones – family, friends, and colleagues you care about – and perhaps putting something for yourself under the tree this year. Recommended Videos Hey, there is a sales tax freeze, after all. And if it’s a tech toy you want to give, there’s no shortage of sleek screens, great games, and smart home-related gear worthy of your consideration. The following are a few thought-starters to suit varying budgets and tastes. For (cold) music lovers You’ve heard of Bluetooth, but what about a Blue Toque? Dress warm for the winter and still take calls and hear your tunes. As the name suggests, the $59 Caseco Blu Toque Cable Knit Bluetooth Beanie is a Bluetooth-enabled toque with built-in headphones that you wirelessly stream music, podcasts, audiobooks or calls from your nearby smartphone – all controlled via onboard controls. Battery life tops six hours between charges. Remove the electronics from its small inside pouch before washing. For budding astronomers (or insomniacs) Project an “out of this world” moving image onto your bedroom ceiling with the Govee Star Light Projector ($89). Capable of creating a stunning 650-square-foot image with a button press on the app (or on the unit itself), with 16 million colours, flowing aurora effects, and 52 scene modes. There are optional white noise tracks, too, and it’s a Bluetooth speaker, if you want to play your own songs. For avid readers Gift the gift of reading with Amazon’s new Kindle Paperwhite (from $185) and Kindle Paperwhite Kids (from $215), both with sharp, anti-glare, 7-inch screens. Now with 20% faster page turns, the new Kindles are also waterproof, so you can take it to the beach, pool, or a bubble bath. An optional backlight lets you read in bed without disturbing anyone. The Paperwhite Kids model also includes a protective folio screen, parental controls, and six months of the Amazon Kids+ service that offers a ton of free content. For gamers on the go The versatile Nintendo Switch ($399) can be played at home on your big-screen TV (in its dock, included), perhaps in a multiplayer match with the family, but it can also be played on the go, such as in the backseat of a car on a road trip, via its built-in screen. A holiday bundle includes the Nintendo Switch console, a digital copy of Mario Kart 8 Deluxe, and a 12-month individual membership to the Nintendo Switch Online subscription service, to play with others over the internet ($100 value). For online shoppers After connecting the $29 Chamberlain Smart Garage Control to your existing garage door system, use the free myQ app (iPhone or Android) to open and close your garage door, anywhere in the world, so you’ll never have to worry about accidentally leaving the garage door open. Or set an open and close schedule. This small doohickey works with Amazon Key In-Garage Delivery, an exclusive Prime member benefit that protects your packages from porch pirates and inclement weather. For thrill seekers From $399 (for 128GB), the new Meta Quest 3S lets you experience mind-blowing 360-degree virtual reality content. Plus, this device supports augmented reality (AR), too, since you can also see the real-world around you in some apps and games (like aliens hiding behind your sofa). Beyond games, Meta Quest 3S is also great for fitness and meditation exercises, chat rooms, virtual concerts and more. It includes a downloadable copy of Batman: Arkham Shadow. For fitness and health nuts Among several other features, Apple Watch can gauge your heart health, track sleep and fitness, show notifications, stream music, and let you pay for items at retail by simply waving your watch over a contactless sensor. Apple Watch Series 10 (from $549) offers a thinner design, bigger and better display, new colours and band options. If you’re shopping for an Android user, the Pixel Watch 3 (from $479) is a stellar pick. For AI lovers (or don’t know it yet) Powered by Google’s ChromeOS, this 14-inch HP x360 laptop (from $699) delivers an enhanced Chromebook experience, with a vibrant touchscreen display that bends back to become a tablet – and twice the storage, speed and memory compared to a regular Chromebook. Google AI tools let you get more done in less time, including handy features like Help Me Write and Magic Editor (to fix up your photos). The Intel Core-powered laptop has an all-day battery, B&O audio, and integrated Google Play store. For speed demons Now available in Ontario and Quebec, TELUS PureFibre is a 100% fibre optic connection to your home that yields internet speeds up to 1.5 gigabits per second (yes, that’s superfast), and complimentary professional installation of award-winning Wi-Fi 6 technology. These kinds of speeds are ideal for 4K streaming, online gaming, and support for multiple devices on the network at the same time (without any lag). TELUS PureFibre Internet starts from $79/month, when bundling with TELUS mobility. For the person who has everything The RayNeo Air 2S ($439) “XR” glasses house twin Micro-OLED 1080p displays that mimic a 201-inch picture for binging TV shows and blockbuster movies – on a plane, in bed, anywhere. And since these 16:9 screens each boast a 120Hz refresh rate, they’re also ideal for fast-moving videogames and sports. Weighing 78 grams and with four integrated speakers, these glasses work with a host of USB-C devices, including newer iPhones, Android devices, computers and game consoles. For nomadic TV bingers For public viewing, on the other hand, the Epson EpiqVision Mini EF22 Portable Smart Laser Projector ($999) produces a superbright image, up to 1000 lumens of colour and white brightness – and no lamp to replace. The 360-swivel stand lets you beam the up-to-150-inch image against a wall or ceiling, or to the backyard for summer movie nights. The Google TV platform is built-in with thousands of apps, such as popular Paramount+ streaming service with exclusive TV shows and movies (from $6.99/month). For serious home theatre enthusiasts Available in six screen sizes ranging, from 42 to 83 inches, and with multiple mounting options, the LG OLED evo C4 TV (from $1,299) features a stunningly sharp display, AI-powered upscaling and a Smart TV powered by webOS. Self-lit pixels create perfect black levels and luminous colours, and so it’s easy to see why OLED is the most desirable panel technology on the market. Along with being ultra-slim and light, the glare-free picture looks great from any angle, so there’s not a bad seat in the room. – Marc Saltzman is the host of the Tech It Out podcast and the author of the book, Apple Vision Pro For Dummies (Wiley)1,591 Graduates Shine at IoBM’s 27 th Convocation “Let us leverage our education to champion corporate social responsibility and actively create a lasting positive impact on society,” remarked Rida Asif, the Valedictorian of the 27 th Convocation of the Institute of Business Management (IoBM). She was also the recipient of the Shahjehan Syed Karim Gold Medal, awarded in honor of IoBM’s late Founder President. This Convocation ceremony, held on Saturday, December 14, 2024, saw 1,591 graduates clad in gowns and caps, their eyes beaming with excitement and a vision for the future. The graduates, awarded degrees in programs ranging from BBA and BS to MBA, MS, MPhil, and PhD, aspire to become future leaders and entrepreneurs. They are eager to put into action the lessons learned in their classrooms. Among the graduating class, 24 distinguished students were awarded gold medals, while 44 received merit certificates. IoBM’s 27 th Convocation was a testament to the diverse journeys of its graduates, each aspiring to make a positive impact on the world through their professional endeavors. The event was honored by the presence of distinguished guests, including Governor Sindh Kamran Khan Tessori as the Chief Guest; Dr. Gohar Ejaz, former caretaker Federal Minister of Commerce, Industry, and Production, as the Guest of Honor; and former caretaker Prime Minister of Pakistan, Anwaarul Haq Kakar. The Keynote Speaker was Yasmin Fasih, an IoBM alumna from the first batch (1997), currently serving as the Regional Human Resource Manager for Operations Execution in the Asia-Pacific region at Maersk, Singapore. Governor Sindh Kamran Tessori, in his address, encouraged the graduates to reflect on the day their parents accompanied them on their first day of school and how their unwavering support has guided them to this significant milestone. He praised the visionary leadership of IoBM’s late Founder President, Shahjehan Syed Karim, for establishing this prestigious institute of higher learning. Tessori called upon the youth to raise their voices, take initiative, and work toward creating a brighter and more promising future for themselves and the nation. The Governor, highlighting the invaluable contributions of IoBM’s late Founder President, Shahjehan Syed Karim, to the field of education, announced his intention to recommend to the President of Pakistan that he be posthumously honored with the prestigious Hilal-e-Imtiaz. Dr. Gohar Ejaz highlighted that the seats occupied by the graduates today represent less than one percent of all graduates, emphasizing the exclusivity and privilege of their achievement. He noted the immense opportunities available in Pakistan and presented an economic overview of the country, illustrating how graduates can contribute to various sectors. “We have immense potential to grow, and what we need today is you!” he concluded. IoBM President Talib Karim presented the Institute’s Progress Report, underscoring IoBM’s dedication to achieving AACSB accreditation, expanding global partnerships for alumni, and integrating advanced technology into the curriculum to enhance the learning experience. He also highlighted the efforts of IoBM’s Center for Islamic Business and Finance, which is actively aligning its initiatives with the broader developmental goals set by the government. In his Welcome Address, IoBM Chancellor Bashir Janmohammad advised the graduates to always respect their parents. He encouraged them to dream big and develop entrepreneurial skills to add value to their lives and careers. He also acknowledged the unwavering support of parents in helping students achieve their dreams. Anwaarul Haq Kakar expressed his excitement about being among the youth, stating, “I feel energized when I am surrounded by young minds brimming with vigor. A formal education helps channel this energy toward meaningful objectives.” He encouraged the graduates to actively contribute to building an egalitarian society where everyone fulfills their role according to their abilities, describing it as the Pakistani dream we must collectively strive to achieve. He also urged the graduates to embrace new aspirations, emphasizing that creativity is deeply connected to the essence of life. During her keynote speech, Yasmin Fasih remarked, “Today, we celebrate the beginning of a new chapter in your lives.” She commended the graduates for their hard work and perseverance, reflecting on her own journey at IoBM and how it played a pivotal role in her success. “Remain deliberate and purposeful in your approach, embrace lifelong learning, and don’t hesitate to take chances in life,” she encouraged. Valedictorian Rida Asif, the proud recipient of the Shahjehan Syed Karim Gold Medal, highlighted the importance of corporate social responsibility in her address. She encouraged her fellow graduates to utilize their education and skills to drive meaningful change and make a positive impact on society. IoBM’s 27th Convocation marked a significant milestone for a diverse group of graduates, culminating their academic journeys and preparing them to embark on impactful professional careers. This milestone event ushered in a new chapter for these graduates, empowering them to contribute meaningfully to Pakistan. As they transition into the professional world, these proud graduates carry with them the values and knowledge instilled by IoBM, equipping them to navigate challenges and seize opportunities with confidence. IoBM boasts a distinguished history of producing successful graduates who now hold prominent positions across diverse sectors, including corporate, banking, and entrepreneurial ventures, both domestically and internationally. This graduation ceremony further solidifies IoBM’s tradition of excellence, reinforcing its position as a leading institution in higher education. The twenty-seven Convocations hosted by IoBM are a testament of the vision of its Late Founder President, Mr. Shahjehan Syed Karim, who established an institute of higher education in 1995. Guided by the principles established by its founder, IoBM, under the current leadership of President Mr. Talib Syed Karim, Vice President of the Foundation for Higher Education and Chief Advisor to IoBM Ms. Sabina Mohsin, along with the Senior Management and Head of Departments, continues to strive for excellence. IoBM comprises four constituent colleges: the College of Business Management (CBM), the College of Computer Science and Information Systems (CCSIS), the College of Engineering and Sciences (CES), and the College of Economics and Social Development (CESD). These colleges offer a diverse range of degree programs encompassing disciplines such as business management, accounting and finance, entrepreneurship, computer science, data science, software engineering, technology management, engineering management, psychology, economics, and media studies, among others. Across over thirty disciplines, IoBM emphasizes a comprehensive curriculum that extends beyond traditional classroom learning. Students not only explore core subject areas but also cultivate essential skills such as leadership, social awareness, and innovation. Experiential learning is central to the academic experience, fostering teamwork, interpersonal communication, foreign language proficiency, and the ability to navigate diverse work environments. The 24 recipients of the gold medals at the IoBM Convocation were: Fatima Sarwar (BBA (Honors) – Janmohammad Dawood), M. Mohib Zafar (BBA (Honors) – Meezan Bank), Laiba Gul Durrani (BBA (Honors) – Ghulam Faruque), Tahreem d/o Aqeel Ahmed Shaikh (BBA (Honors)- Shan Foods), Maaha Jetha (BBA (Honors) – Mondelez Pakistan), Sandesh Kumar (BS (Honors) Accountancy, Management and Law – Faizan Steel), Muhammad Faizan Abid (BS (Actuarial Science and Risk Management) – EFU Life Assurance), Simran Ashok (BS (Computer Science- PayPak), Yameena Nasir (BS (Honors) Accounting and Finance – EFU Life Assurance), Syeda Manahil Amin (BS (Honors) Accounting and Finance – Westbury Group of Companies), Madiha Zehra Misri (BS (Data Science) – Dr. Ahmer Syed Karim), Aiyza Ahmed (BS (Mathematics and Economics) – Imam Ali Kazi Memorial), Maira Rais (BS (Social Entrepreneurship and Leadership) – Management Association of Pakistan), Zulekha Adnan (BS (Industrial Management) – Upfield Pakistan), Siddiqa Asim (BS (Entrepreneurship) -Tufail Industries), Alishba Khursheed (BS (Economics, Law and International Relations) – S. H. Hashmi Memorial), Laiba Adnan (BS (Honors) Business and Psychology – DVAGO), Eisha Wahid (BS (Logistics and Supply Chain Management) – Afeef Packages), Rida Asif (BS (Honors) Economics and Finance – Shahjehan Syed Karim), Alifya Tinwala (BS (Education) – Dr. Essa’s Laboratory), Ursalan Ilyas (MBA (Industrial Management) – President IoBM), Lalit Kumar (MBA (Weekend) – Orient McCann), Yaseen Raza Haider (MBA (Logistics and Supply Chain Management) – Jubilee General Insurance) and Muhammad Abbas (MSc in Organizational Psychology and HRM – Tabba Foundation). Merit certificates were awarded to students across various degree programs, as follows: BBA (Honors): Ayesha Khan, Haris Muhammad Shahid, Fiza d/o Imtiaz Hassan, Amina Butt, Maria Nisar, Zainab d/o Muhammad Javed, Shamikh Pervez, Humza Ahmed Khan, Bushra Nadeem, Haya Khan, Mohammad Hamza Brohi, Ayesha Abdul Samad, Khadija Siddiqi, Aimen Adnan, Unzilla Shaikh, Farzeen d/o Karim, Maham Saqib, Tooba Najm-ul-Hasan, Sara Ghani, Umm-e-Abiha Ameer and Saad Iftikhar. BS (Honors) Accountancy, Management and Law: Areeba d/o Muhammad Jawaid and Minahil Fakhir. BS (Computer Science): Mubashir Bhania. BS (Honors) Accounting and Finance: Rizwan Abbas, Muhammad Ali Imran Mamsa, Syed Mohammad Saud Tauqir and Daniya Nadir Merchant. BS (Social Entrepreneurship and Leadership): Hira Sohail and Asma d/o Abdul Hafeez. BS (Honors) Business and Psychology: Manal Tariq, Ayesha Tariq Khan, Sania Khalid, Fatima Ahmed, Aqsa d/o Muhammad Shahid and Rihab Khalid Khan. BS (Honors) Economics and Finance: Ramsha Shaikh. BS (Education): Arwa Abbas. B.Ed.: Eman Sadiq, Hira Ahmed and Maria Ahmed. M.Phil (Organizational Psychology): Tayyiba Imtiaz. PhD (Education): Diana Louisa Ambrose and Dania Shoaib Khan. IoBM’s graduating class of 2024 joins a distinguished lineage of IoBM alumni, carrying forward the legacy of its Late Founder President, Mr. Shahjehan Syed Karim. Established under his guidance, IoBM has consistently strived to cultivate intellectual growth and social responsibility within its students. This commitment, rooted in the belief in education’s transformative power, has propelled IoBM to its position as a leading institution of higher learning in Pakistan. As these graduates embark on their professional journeys, they carry with them the core values instilled by IoBM: academic excellence, ethical conduct, and a commitment to making a positive impact on society. IoBM’s 27 th Convocation was more than just a graduation ceremony. It was a celebration of triumph, a testament to the dedication and hard work of the graduating class, and a recognition of the unwavering support of parents and faculty members. This momentous occasion served as a reminder of the bright future that awaits these accomplished individuals. Save my name, email, and website in this browser for the next time I comment. Δ document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() );
The TOI Entertainment Desk is a dynamic and dedicated team of journalists, working tirelessly to bring the pulse of the entertainment world straight to the readers of The Times of India. No red carpet goes unrolled, no stage goes dark - our team spans the globe, bringing you the latest scoops and insider insights from Bollywood to Hollywood, and every entertainment hotspot in between. We don't just report; we tell tales of stardom and stories untold. Whether it's the rise of a new sensation or the seasoned journey of an industry veteran, the TOI Entertainment Desk is your front-row seat to the fascinating narratives that shape the entertainment landscape. Beyond the breaking news, we present a celebration of culture. We explore the intersections of entertainment with society, politics, and everyday life. Read More Malavika Mohanan redefines elegance in a timeless red chiffon saree 9 morning habits to get rid of stomach discomfort 9 popular Korean desserts to try before 2024 ends Inside Alia Bhatt's love-filled Christmas celebration with Ranbir Kapoor, Raha and family 10 perfect baby names for kids born on a Thursday 10 countries with most cancer rates, see where India stands 10 things true friends don't do New Year dishes traditionally prepared in various Indian states In pics: Anil Ambani's grand and luxurious home 'Abode'The standard Lorem Ipsum passage, used since the 1500s "Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum." Section 1.10.32 of "de Finibus Bonorum et Malorum", written by Cicero in 45 BC "Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?" Thanks for your interest in Kalkine Media's content! To continue reading, please log in to your account or create your free account with us.
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Did Luigi Mangione and lawyer wear matching outfits? Why was Brian Thompson's accused killer smiling in court?Colin Smalls puts up 23 points as American tops UAlbany 81-77 at Puerto Rico ClassicoRosen Law Firm Encourages Franklin Resources, Inc. Investors to Inquire About Securities Class Action Investigation - BEN
Democratising AI needs a radically different approachInside Tess Daly's incredible home with Vernon Kay - from quirky pets to one thing causing unbelievable stressPeople comfort their children suffering from dengue fever at a government hospital in Dhaka on ... [+] October 19, 2022. (Photo by Munir uz ZAMAN / AFP) (Photo by MUNIR UZ ZAMAN/AFP via Getty Images) Dengue is a miserable illness caused by infection with any of the four dengue viruses (dengue-1, -2, -3, and -4). Infections have increased dramatically over the past two years while, at the same time, developers of anti-dengue drugs and vaccines have abandoned their research and development efforts. As a result, public health officials and clinicians are becoming increasingly concerned about their limited options to keep their populations and patients safe. The Dengue Problem is Worsening The dengue viruses primarily circulate in the tropics and subtropics and are transmitted to people by infected mosquitoes. There are an estimated 400 million infections every year making about 100 million people ill. Many recovering patients have told me dengue made them feel so sick they thought they were going to die. Annual dengue fatalities range between 8,000-40,000 people per year, with many deaths occurring in children. Once infected with a specific dengue virus, the individual will develop immunity against that virus and be protected from future illnesses for years. However, a person can always be infected a second time with a different dengue virus. It is these second infections where the risk of severe dengue and death is highest. Third or fourth infections usually do not make people very ill because of the immunity developed from the first two infections. Beginning in 2023, the global dengue problem started to significantly worsen. Dengue cases skyrocketed around the world not only in locations known to be endemic for the viruses like Central and South America and Southeast Asia, but also in new locations such as Nepal and Bangladesh. Infections this year alone are more than 300 % higher in the Caribbean and Americas compared to the average of the last five years. Cases have also started popping up in more temperate climates. France had more locally acquired dengue virus infections in 2024 than any year prior . In 2023 and 2024 the U.S. experienced an increase in the number of people becoming infected while traveling (4,730). There was also a rise in locally acquired dengue infections in places like Florida (249), Texas (2) and California (17). Puerto Rico frequently has dengue outbreaks and experienced a rise in infections with 6,452 reported cases. The Fed’s ‘Biggest Nightmare’ Is Suddenly Coming True As Bitcoin Price Surges Elon Musk Xmail Teaser Poses New Threat For Billions Of Gmail Users Mystery Drones Saga: Rand Paul Blocks Expedited Drone Bill (Updated) Where Are the Anti-Dengue Vaccines and Drugs? At the same time dengue infections are surging, vaccine and drug developers have started calling it quits in the fight against dengue. Sanofi had one of only two licensed dengue vaccines (Dengvaxia), and the only vaccine licensed in the United States. The company recently announced it will stop manufacturing Dengvaxia and existing supplies will fade away by August 2026. The company cited low global demand as the reason for discontinuing a vaccine which took over two decades and cost more than $1.5 billion dollars to develop. The other licensed dengue vaccine (TAK-003) is made by the Japanese vaccine developer Takeda. Although TAK-003 is a modest improvement over Sanofi’s vaccine, it too has significant limitations. The vaccine has a better safety profile than Dengvaxia, but it does not seem to work against the dengue-3 virus, only the dengue-1 and dengue-2 viruses. It is unclear if works against dengue-4. Millions of TAK-003 vaccine doses were provided to countries in Latin America during the recent dengue surge and observations on safety and effectiveness from real world use will be available in the coming years. The U.S. may or may not benefit from this data because the company pulled out of the Food and Drug Administration review process required for vaccine licensure. It remains to be seen whether Takeda will re-engage with the FDA and if TAK-003 will ever be available in the United States. Janssen, a company of Johnson & Johnson, has also recently thrown in the towel in the fight against dengue. The company announced that it will cease development of a drug candidate (Mosnodenvir) designed to be the first anti-viral treatment for dengue. It is unclear if another developer will license the drug and continue its development. As with Dengvaxia, Janssen’s decision represents years of lost effort and millions of dollars. (Disclosure: Throughout my career I have consulted with anti-dengue vaccine and drug developers to include Sanofi, Takeda, Janssen and Merck.) Are We Losing the Dengue War? There are plenty of reasons to be pessimistic about our ability to confront the global dengue problem and prevent its further expansion into the United States. Changing temperature and rainfall patterns have allowed the mosquito species that transmit dengue to flourish in the U.S. and extend to areas where they were not seen previously. This is a similar trend to what is being observed for diseases transmitted by ticks . A second reason for concern is that every year more than 15 million travelers enter the U.S. coming from areas where dengue viruses circulate. More than 30 million Americans travel to and return from similar areas. Every traveler has the potential to introduce a dengue virus into the country. More dengue viruses and more mosquitoes capable of transmitting them does not bode well for populations like the U.S. where most people lack immunity to any of the four dengue viruses. Air-conditioning, indoor plumbing, and window screens can limit high intensity human and mosquito interactions lowering the likelihood the U.S. will experience major dengue epidemics similar to those in Latin America and Southeast Asia. However, smaller local outbreaks like those in Key West, Florida (2009-2010) and Hawaii (2015-2016) remain possible and will stress local health care systems and cost millions of dollars to manage. Another potential bright spot is that some scientists continue to develop anti-dengue vaccine and drug candidates. There is also interest in using newer antibody infusion technologies, like what was used to treat COVID-19 patients, to prevent or treat dengue virus infections. Antibody preparations could provide short term protection from dengue during outbreaks or as a treatment for people already infected. The Serum Institute of India is field testing an antibody preparation designed to treat dengue virus infected patients. The antibodies are supposed to interrupt the virus’s multiplication in the body, thereby reducing the severity of illness patients experience. Academic groups and U.S. government agencies are also exploring the use of manufactured anti-dengue antibodies. On the vaccine front, the Instituto Butantan (Brazil) licensed dengue vaccine technology from the U.S. National Institutes of Health and have completed a large (~16,000 people) field trial testing their vaccine formulation (Butantan-DV). The vaccine appears well tolerated and prevents a significant proportion of dengue-1 and dengue-2 illnesses. The company announced it has provided Brazilian regulators (Anvisa) all the final documentation required for them make a determination on whether the vaccine can be registered and made available in Brazil. Panacea Biotech in India licensed the same NIH materials and started a large-scale vaccine field trial in 2024 . Merck (MSD) is another licensee and is also expected to launch field trials . If the vaccine is successful and MSD pursues a license in the U.S., access remains years away. What About the Future of Dengue Research? Even though academic, government, and industry groups are working on developing dengue prevention and treatment options now, there is a real risk that the resources supporting this work could soon dry up. For over a century, the U.S. government has played an important role in advancing dengue research through work in the Department of Defense , Centers for Disease Control and Prevention, and the NIH. The government has also influenced scientific advancement through its various external funding mechanisms. These activities have incentivized industry to take on the financial and scientific risk associated with developing vaccines and drug candidates where the market for the final products is unpredictable. The shared risk approach has been productive. Depending on who Congress confirms to lead the U.S. Health and Human Services and its family of subordinate agencies, infectious diseases research could be significantly de-prioritized and under resourced in both money and human capital. This would certainly limit the U.S. government’s footprint in the dengue research landscape, but also dissuade other entities from starting or continuing their dengue work. All of this would be bad news for countries like the U.S. who are almost certainly going to confront a worsening dengue problem, but currently have very few tools at their disposal to prevent or manage the infections.( MENAFN - KNN India) New Delhi, Dec 14 (KNN) In a significant stride towards self-reliance in defence, India's Ordnance Parachute Factory (OPF) in Kanpur has begun manufacturing pilot parachutes for the indigenous Tejas fighter aircraft. This development marks a critical milestone in reducing dependence on foreign imports for essential defence equipment. Previously, the Indian Air Force relied on parachutes imported from Europe and the U.S. to ensure the safety of fighter pilots during emergency ejections. The new indigenous parachutes, tailored for the high-speed Tejas aircraft, are designed to function effectively at speeds up to 2,205 km/h and altitudes of 50,000 feet, meeting the exacting demands of modern air combat. The Defence Research and Development Organisation's (DRDO) Aerial Delivery Research and Development Establishment (ADRDE) played a pivotal role in designing the parachutes, which are being manufactured by OPF, a unit of Gliders India Limited under the Ministry of Defence. These parachutes are engineered to integrate seamlessly with Tejas' ejection systems, ensuring pilot safety during high-stakes operations. A standout feature of these parachutes is their cost-effectiveness. Priced at ₹8 lakh each, they are nearly half the cost of imported equivalents while maintaining international standards of reliability and strength. Weighing approximately 8 kg with a total length of 12 meters, the parachutes are versatile enough to be used in various aircraft, including the Sukhoi, Mirage, Jaguar, and MiG. Additionally, OPF has established a dedicated workshop for producing these parachutes, employing 65 women, aligning with the government's push for gender inclusion in defence manufacturing. This initiative not only supports self-reliance but also empowers women in a traditionally male-dominated industry. With OPF becoming Asia's first factory to produce such advanced, affordable parachutes, India is solidifying its position as a leader in aerospace technology. This achievement enhances the safety of fighter pilots, bolsters indigenous capabilities, and underscores India's commitment to self-reliance in critical defence sectors. (KNN Bureau) MENAFN14122024000155011030ID1108993093 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.
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