Steam Week Sales Chart: "Path of Exile 2" Takes the Top Spot, "PUBG" Ranks Third
SEATTLE (AP) — The Seattle Seahawks were struggling a week ago, coming off their bye having lost five of their last six games. That included a gut-punch overtime defeat at home against the Los Angeles Rams on Nov. 3. The outlook for the last-place Seahawks (5-5) was beginning to look grim. They suddenly have renewed optimism this week after an uplifting victory over the San Francisco 49ers that snapped a six-game losing streak against their arch-rival that dated to 2021. Seattle will play the first-place Arizona Cardinals (6-4) on Sunday for a share of the NFC West lead. How quickly things change in the NFL. “We’ve earned the opportunity to be fighting for the lead in the division going into the home stretch,” Seahawks coach Mike Macdonald said. “So that’s the way we’re treating it. It’s very much like a playoff mindset for us at this point.” The win over the 49ers, which was capped by a 13-yard touchdown run by quarterback Geno Smith with 18 seconds left, put the Seahawks in a much better place mentally than they’d been in over the previous six weeks. They're hoping it's just the start of something even bigger. “It can just spark something that you’ve been looking for this whole year,” wide receiver DK Metcalf said. “I know we started off very hot with the first three games, but, you know, when adversity hit, it’s all about how you respond. I think we responded the right way, and it’s going to carry us throughout the rest of the season.” While the Seahawks are feeling better this week, the Cardinals have plenty of reason to feel optimistic, too. After starting the season 2-4, Arizona has won four straight to put itself in first place in the NFC West. The Cardinals have a defense that is making big strides under the leadership of veteran safety Budda Baker and a top-five running game behind the dual threat of running back James Conner, who has 697 yards rushing, and quarterback Kyler Murray, who seems to be hitting his stride in his sixth NFL season. Murray has 2,058 yards passing with 12 touchdowns, and has rushed for 371 yards and four scores. Second-year head coach Jonathan Gannon has been impressed with Murray’s improved decision-making as Murray has thrown just three interceptions through 10 games. “There’s times that he probably wants to try to thread it a little bit, but understands when to pick and choose his spots,” Gannon said. “I think he’s done a phenomenal job with that and there are a lot of times throughout the game where you could say we like to put it in the quarterback’s hands, and you trust him to make the right decision for that point in the game.” Reunited Seahawks wide receiver Jaxon Smith-Njigba will see a familiar face on the other sideline Sunday in rookie Marvin Harrison Jr., who was Smith-Njigba’s college teammate at Ohio State in 2021 and 2022. The pair each caught three touchdowns in the Buckeyes’ wild win over Utah in the 2022 Rose Bowl, with Smith-Njigba having 347 yards receiving on what was a 573-passing yard day for C.J. Stroud, now the quarterback of the Houston Texans. “Late his freshman year, he really just stood out,” Smith-Njigba said of Harrison. “You could just see the growth and kind of who he is becoming. ... He’s passed a lot of people’s expectations, of course, but I knew he was going to be elite later on freshman year.” MVP-level Murray Murray is coming off one of the best games of his career after completing 22 of 24 passes for 266 yards and a touchdown against the Jets two weeks ago. He also ran for 21 yards and two TDs. Murray currently ranks No. 3 in the NFL in quarterback rating behind Cincinnati's Joe Burrow and Baltimore's Lamar Jackson. That has put him in the MVP conversation, particularly since Arizona has won four straight games. “I don’t play the game for the validation of others," Murray said. "But as a player, of course, sometimes the recognition and the words being said feel good. But it doesn’t satisfy me.” Defensive improvement The most surprising part of Arizona’s four-game winning streak is the rapid improvement of the defense, which has allowed just 9 and 6 points, respectively, over the past two games. No touchdowns have been allowed – just five field goals. It’s just the second time over the past 30 years that the franchise has allowed 10 points or less over back-to-back games. Baker, a Bellevue native and former University of Washington football star, is the unquestioned leader of the bunch – he already has 100 tackles over 10 games - but the team also has a strong core of linebackers in Kyzir White, Mack Wilson and Zaven Collins. Metcalf and Baker have gone up against each other many times before, most famously when Metcalf ran Baker down on an interception return in 2020. “You really can’t prepare for a guy like that because his engine never stops,” Metcalf said. “He’s always going to be around the ball. He’s always going to affect the game with just his play effort and play style. ... Just got to try to minimize his playmaking ability as much as we can on offense.” ___ AP Sports Writer David Brandt in Phoenix, Arizona, contributed to this report. ___ AP NFL: https://apnews.com/hub/nfl Shane Lantz, The Associated Press
Tinubu Arrives Paris For Three-day State Visit To FranceNatixis Advisors LLC Has $3.10 Million Position in Camden Property Trust (NYSE:CPT)Alibaba Cloud emphasized its commitment to the highest standards of safety and security for its data centers and facilities. The company stated that a thorough investigation would be conducted to determine the cause of the fire and to implement any necessary enhancements to prevent similar incidents in the future. Additionally, Alibaba Cloud reiterated its dedication to ensuring the continuity and reliability of its services for customers across the globe.
PLEASANTON, Calif. , Dec. 23, 2024 /PRNewswire/ -- 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today it had secured a permanent injunction in the U.S. District Court for the District of Delaware against the GeoMx products sold by Bruker Corporation (Nasdaq: BRKR), which acquired the product line from NanoString Technologies. To minimize the risk of disruption to ongoing research, 10x Genomics requested a carve-out for GeoMx users who installed an instrument prior to the trial in November 2023 . The injunction, which the Court said it will enter in January 2025 , is expected to prohibit Bruker from making, using, selling or offering to sell in the United States its GeoMx Digital Spatial Profiler and associated instruments, reagents and services for RNA and protein detection. At the request of 10x Genomics, the injunction will not block ongoing research by researchers who installed a GeoMx instrument prior to November 18, 2023 . Such customers can continue to purchase GeoMx reagents for use with existing GeoMx instruments for purposes of continuing their ongoing research. The Court found that making such an exception for ongoing research strikes a "workable balance between protecting the patentee's rights and protecting the public from the injunction's adverse effects." In addition, the Court affirmed the $31 million damages awarded by the November 2023 jury verdict, as well as supplemental damages and interest that will be added to the total damages when final judgment is entered. "Today's decision helps to safeguard our decade-long investment in innovation and ensures we can continue to develop groundbreaking technologies that help our customers revolutionize science," said Eric Whitaker , Chief Legal Officer at 10x Genomics. "10x exists to fuel scientific progress – not stifle it – and that is why we've done our utmost to ensure this injunction was structured to protect both our intellectual property and existing GeoMx customers' ongoing research." The Court recognized the harm NanoString's infringing conduct caused 10x when it wrote in its ruling, "Having been careful not to license its technology, 10x suffers when it proclaims itself as an innovator in spatial genomics but a competitor is using the same innovative, patented technology." Today's Court decision follows a November 2023 jury verdict that found that NanoString's GeoMx products willfully infringed seven patents exclusively licensed to 10x Genomics by Prognosys. During the trial, the jury heard testimony from the sole inventor of the patents, Illumina co-founder Mark Chee , and NanoString CEO Brad Gray and NanoString CSO Joe Beechem. After hearing all of the evidence, the jury determined that all seven patents had been infringed by NanoString, that each patent was valid, that NanoString willfully infringed those patents and that monetary damages were owed to 10x for the infringement of all seven patents. In affirming the jury's finding that NanoString willfully infringed, the Court relied on the evidence showing that NanoString knew or was willfully blind that its acts would cause infringement of 10x's rights. The asserted patents in Case No. 21-cv-653-MFK include (a) U.S. Patent No. 10,472,669; (b) U.S. Patent No. 10,961,566; (c) U.S. Patent No. 10,983,113; (d) U.S. Patent No. 10,996,219; (e) U.S. Patent No. 11,001,878; (f) U.S. Patent No. 11,008,607 and (g) U.S. Patent No. 11,293,917. About 10x Genomics 10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter) . Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the "safe harbor" created by those sections. All statements included in this press release, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may," "might," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "see," "estimate," "predict," "potential," "would," "likely," "seek" or "continue" or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding litigation and remedies as well as possible outcomes of litigation. These forward-looking statements do not reflect that our success will depend on our ability to obtain, maintain and protect our intellectual property rights, intellectual property litigation could be expensive, time-consuming, unsuccessful and could interfere with our ability to develop, manufacture and commercialize our products or technologies, litigation outcomes are unpredictable or there may be changes in our litigation strategy. These statements are based on management's current expectations, forecasts, beliefs, assumptions and information currently available to management. Actual outcomes and results could differ materially from these statements due to a number of factors and such statements should not be relied upon as representing 10x Genomics, Inc.'s views as of any date subsequent to the date of this press release. 10x Genomics, Inc. disclaims any obligation to update any forward-looking statements provided to reflect any change in 10x Genomics' expectations or any change in events, conditions or circumstances on which any such statement is based, except as required by law. The material risks and uncertainties that could affect 10x Genomics, Inc.'s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in the company's most recently-filed 10-K for the fiscal year ended December 31, 2023 and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time. Disclosure Information 10x Genomics uses filings with the Securities and Exchange Commission, our website ( www.10xgenomics.com ), press releases, public conference calls, public webcasts and our social media accounts as means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD. Contacts Investors: investors@10xgenomics.com Media: media@10xgenomics.com View original content to download multimedia: https://www.prnewswire.com/news-releases/us-district-court-awards-10x-genomics-permanent-injunction-in-patent-infringement-lawsuit-against-bruker-corporations-geomx-products-302338627.html SOURCE 10x Genomics, Inc.Had the United Conservative Party (UCP)’s John Middleton-Hope won Wednesday’s by-election in Lethbridge-West, one wonders if Health Minister Adriana LaGrange would have invited him along yesterday to help her make her long-overdue announcement of the government’s funding agreement with Alberta doctors? Alas for the UCP, Middleton-Hope was not the winner of the by-election. The Alberta NDP’s Rob Miyashiro was, so Premier Danielle Smith had to satisfy herself by publishing a longish post on social media congratulating Middleton-Hope for losing the election. There was nary of a word of congratulations for the winner, of course, but that’s how the UCP rolls. Alberta Conservatives are poor losers. But it’s always worth keeping in mind that, as Smith’s government illustrates daily, they’re worse winners! Smith’s note congratulating the loser for his loss included this interesting phrase: “While we did not come away with a win, our candidate and the UCP gained a higher percentage of votes than we had earned in the 2023 General Election.” Let’s pause for a moment to examine this bit of hyperbole: On Wednesday, Middleton-Hope captured 44.9 per cent of the vote, an increase of a whopping 2.4 per cent over the 42.5-per-cent accumulated UCP candidate Cheryl Seaborn in the 2023 general election. By this standard, the UCP would also be entitled to boast that Mr. Middleton-Hope’s tally also topped party standard-bearer Karri Flatla’s 44.3 per cent in the 2019 general election. Another way to describe this phenomenon, of course, would be to say that no matter how many people vote in Lethbridge-West – 13,561 on Wednesday compared to 22,635 in the 2023 general election – the UCP just can’t seem to get past 45 per cent. There are about 37,000 eligible voters in the riding nowadays. Indeed, the last time a Conservative candidate got more than that – 48 per cent – the winner was Progressive Conservative Clint Dunford, the premier was named Ralph Klein, and the year was 2001. Dunford passed away in 2021. On Wednesday, Miyashiro, the winner, captured 53.4 per cent of the ballots cast, compared with the 53.9 per cent taken by former MLA Shannon Phillips in 2023 – so, a Conservative might argue, this was a percentage loss almost as huge as the increase posted by Middleton-Hope! Pay deal for family docs is finally official – almost Getting back to LaGrange’s announcement, the deal agreed to by the government and the Alberta Medical Association (AMA), which bargains collectively for the province’s physicians, will provide a new payment option to family docs who have a full-time practice with 500 or more patients. It is expected to increase pay for many physicians. This may in fact make it a little easier to recruit more doctors to Alberta. The big mystery that went unacknowledged in the government’s press release yesterday is why a deal has that was first announced by the government on April 17 has been sitting on a desk in the provincial Treasury Department for almost long enough to bring a baby to term while AMA leaders pleaded with the government to sign and implement what they’d agreed to. “This agreement should have been done back in May when the premier promised it would be signed within a couple of weeks,” NDP Health Critic Sarah Hoffman remarked yesterday. Speculation has been that the government didn’t want to reveal anything that might impact ongoing negotiations with other health care workers such as nurses, medical technologists and care aids, not to mention civil servants, municipal employees, schoolteachers and other education workers. An additional $250 million a year for physician compensation might well have an impact on their demands. The agreement still hinges on the willingness of a minimum of 500 doctors to take part in the new funding formula, so while the deal is done, it’s not really a done deal just yet. UCP claims Chief Actuary’s CPP pullout estimate is missing According to a political aide to Finance Minister Nate Horner, a report by the Chief Actuary of Canada on the UCP’s scheme to pull Alberta out of the Canada Pension Plan is missing an estimate of how much the province would be entitled to get from the CPP’s huge investment fund. “We received their interpretation of the legislation, but it did not contain a number or even a formula for calculating a number,” the CBC quoted press secretary Justin Brattinga saying yesterday. Just a suggestion, but before we all freak out, perhaps someone should put in a call to the office of Chief Actuary Assia Billig to see what’s going on. There has been, for one thing, some stuff taking place in Ottawa in the past few days related to federal government financing, and the finance minister who asked the Chief Actuary to deliver the report is no longer on the job. Moreover, even without a need to replace a federal finance minister in a hurry and deliver a financial update, the week before Christmas seems like a peculiar time for the Chief Actuary’s estimate to have been expected by the province. One thing that can be safely assumed is that with or without the Chief Actuary’s full report, the UCP’s estimate that Alberta, with about 11.5 per cent of Canada’s population, is owed 53 per cent of the CPP fund is both preposterous and obviously politically motivated. Meanwhile, the UCP continues to refuse to provide any details of what the 94,000 Albertans who filled out the government’s flawed online survey last fall on replacing the CPP with an Alberta pension plan had to say. It’s not hard to guess why. The Sovereignty Act : Sound and fury, signifying nothing If you have time this holiday season, it would be well spent reading the latest post on the University of Calgary Law Faculty’s blog , in which Professor Emeritus Nigel Banks and Assistant Professor Martin Z. Olszynski examine the Smith Government’s use of its Sovereignty Act to try to try to derail the federal greenhouse gas emissions cap. With a Shakespearean flourish, they find the government’s legal strategy to be “a tale told by an idiot, full of sound and fury, signifying nothing.” ( The Tragedy of Macbeth , Act V, Scene 5, in case you missed the performance.) “Such motions, even when implemented, can do nothing to better the legal position of the province when faced with federal statutes and regulations with which it does not agree,” the authors conclude. “This is indeed political theatre.” Support rabble today! We’re so glad you stopped by! Thanks for consuming rabble content this year. rabble.ca is 100% reader and donor funded, so as an avid reader of our content, we hope you will consider gifting rabble with a donation during our summer fundraiser today. Nick Seebruch, editor Whether it be a one-time donation or a small monthly contribution, your support is critical to keep rabble writers producing the work you’ve come to rely on as a part of a healthy media diet. Become a rabble rouser — donate to rabble.ca today. Nick Seebruch, editor Support rabble.caThe avian influenza outbreak in Japan serves as a stark reminder of the constant threat posed by infectious diseases in the agriculture sector. It highlights the need for robust biosecurity measures, effective disease management strategies, and close cooperation between farmers, government agencies, and health authorities to mitigate the impact of such outbreaks. As the poultry industry grapples with the aftermath of the culling, efforts are being made to strengthen defenses against avian influenza and protect the livelihoods of poultry farmers across Japan.
As the rumors of marriage troubles continue to swirl, fans can only wait and hope for a statement from the couple to address the speculation once and for all. With both Chen Xiao and Michelle Chen maintaining their silence on the matter, the true state of their relationship remains a mystery.Iranian Ambassador Warns of Consequences of Assad Regime's Collapse, Potential Regional Conflict
In the midst of this uncertainty, Defense Minister Suh Wook's steadfast leadership and the Ministry of National Defense's reaffirmation of the military's allegiance provide a sense of reassurance to the South Korean public and international observers. The maintenance of the military chain of command and operational readiness is vital to ensuring that national security interests are protected and that the country is prepared to respond to any external threats or emergencies.From its inception, Xiaomi Automotive has positioned itself as a disruptor in the traditional automotive space, leveraging its tech prowess to create cutting-edge electric vehicles that are both efficient and environmentally friendly. With a focus on smart features and connectivity, Xiaomi's electric cars have captured the imaginations of tech-savvy consumers who value a seamless integration of technology into their daily lives.
Looking back on the changes that occurred in 2004, it's clear that the seeds of the digital future were being sown. Little did we know then that the innovations of that time would continue to evolve and shape the world we live in today.In conclusion, the full rollout of personal pension systems and the ongoing optimization of these schemes are essential steps towards strengthening retirement security for individuals. By expanding access, improving investment choices, and enhancing regulations, personal pensions can play a significant role in ensuring a comfortable and financially stable retirement for people around the world. As we continue to navigate the challenges posed by an aging population, the development of robust and effective personal pension systems will be instrumental in creating a more secure and prosperous future for retirees.As a result of these issues, the number of complaints regarding Tencent Video membership benefits has reached a concerning level. Users have taken to social media, forums, and review sites to express their discontent and call for improvements. It is clear that Tencent Video must take action to address these criticisms and make necessary changes to regain the trust and loyalty of its user base.
Beyond her achievements on the volleyball court, Lang Ping is admired for her humility, integrity, and grace. She serves as a role model for athletes around the world, demonstrating the power of hard work, perseverance, and sportsmanship. Her influence extends far beyond the boundaries of the volleyball court, inspiring individuals from all walks of life to strive for excellence and push past their limits.
Chiefs win at the buzzer again, topping Panthers 30-27 with field goal
The investigation by CCTV has shed light on the hidden truth behind virtual live streaming rooms, revealing the extent of deception and manipulation that takes place in this booming industry. The "factory" where green screen synthesis occurs is a testament to the lengths that streamers will go to in order to attract viewers and boost their popularity.Brown & Brown ( NYSE:BRO – Free Report ) had its target price increased by Barclays from $108.00 to $119.00 in a report published on Thursday morning, Benzinga reports. They currently have an equal weight rating on the financial services provider’s stock. BRO has been the topic of several other reports. Truist Financial upped their price target on shares of Brown & Brown from $116.00 to $118.00 and gave the stock a “buy” rating in a research report on Wednesday, October 30th. Keefe, Bruyette & Woods raised their target price on shares of Brown & Brown from $86.00 to $92.00 and gave the company an “underperform” rating in a research note on Friday, July 26th. Wells Fargo & Company lifted their price target on Brown & Brown from $112.00 to $114.00 and gave the stock an “overweight” rating in a report on Thursday, October 10th. Royal Bank of Canada upped their price objective on Brown & Brown from $113.00 to $118.00 and gave the company an “outperform” rating in a research note on Wednesday, October 30th. Finally, Jefferies Financial Group lifted their target price on Brown & Brown from $98.00 to $104.00 and gave the stock a “hold” rating in a research note on Wednesday, October 9th. One analyst has rated the stock with a sell rating, five have issued a hold rating and seven have assigned a buy rating to the stock. According to MarketBeat, the stock currently has a consensus rating of “Hold” and a consensus price target of $107.42. Check Out Our Latest Report on BRO Brown & Brown Trading Up 1.2 % Brown & Brown ( NYSE:BRO – Get Free Report ) last posted its quarterly earnings results on Monday, October 28th. The financial services provider reported $0.91 earnings per share for the quarter, beating analysts’ consensus estimates of $0.88 by $0.03. Brown & Brown had a return on equity of 17.12% and a net margin of 22.65%. The firm had revenue of $1.19 billion during the quarter, compared to the consensus estimate of $1.16 billion. During the same period last year, the company earned $0.71 earnings per share. The business’s revenue was up 11.0% compared to the same quarter last year. On average, equities analysts expect that Brown & Brown will post 3.74 earnings per share for the current fiscal year. Brown & Brown Increases Dividend The firm also recently disclosed a quarterly dividend, which was paid on Wednesday, November 13th. Shareholders of record on Wednesday, November 6th were issued a $0.15 dividend. The ex-dividend date was Wednesday, November 6th. This represents a $0.60 dividend on an annualized basis and a yield of 0.54%. This is an increase from Brown & Brown’s previous quarterly dividend of $0.13. Brown & Brown’s payout ratio is currently 16.35%. Insider Transactions at Brown & Brown In other news, Chairman Hyatt J. Brown sold 134,640 shares of the company’s stock in a transaction on Thursday, August 29th. The stock was sold at an average price of $104.51, for a total transaction of $14,071,226.40. The transaction was disclosed in a filing with the Securities & Exchange Commission, which is available through this hyperlink . Insiders own 17.02% of the company’s stock. Institutional Inflows and Outflows A number of hedge funds and other institutional investors have recently bought and sold shares of BRO. Studio Investment Management LLC raised its holdings in shares of Brown & Brown by 1.5% during the 3rd quarter. Studio Investment Management LLC now owns 6,513 shares of the financial services provider’s stock worth $675,000 after buying an additional 96 shares in the last quarter. Oregon Public Employees Retirement Fund grew its holdings in shares of Brown & Brown by 0.5% during the second quarter. Oregon Public Employees Retirement Fund now owns 20,339 shares of the financial services provider’s stock worth $1,819,000 after purchasing an additional 100 shares during the last quarter. Trust Point Inc. increased its stake in shares of Brown & Brown by 4.3% in the third quarter. Trust Point Inc. now owns 2,519 shares of the financial services provider’s stock valued at $261,000 after buying an additional 103 shares during the period. Creative Planning raised its holdings in Brown & Brown by 0.4% in the 3rd quarter. Creative Planning now owns 29,892 shares of the financial services provider’s stock valued at $3,097,000 after buying an additional 112 shares during the last quarter. Finally, Crossmark Global Holdings Inc. grew its holdings in Brown & Brown by 0.5% during the 3rd quarter. Crossmark Global Holdings Inc. now owns 22,929 shares of the financial services provider’s stock worth $2,375,000 after acquiring an additional 113 shares during the last quarter. Institutional investors and hedge funds own 71.01% of the company’s stock. About Brown & Brown ( Get Free Report ) Brown & Brown, Inc markets and sells insurance products and services in the United States, Canada, Ireland, the United Kingdom, and internationally. It operates through four segments: Retail, National Programs, Wholesale Brokerage, and Services. The Retail segment provides property and casualty, employee benefits insurance products, personal insurance products, specialties insurance products, risk management strategies, loss control survey and analysis, consultancy, and claims processing services. 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