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Ronaldo lifts Al Nassr to brink of Champions League last 16The police are reporting that the teen boys seen in a video sexually assaulting a schoolgirl have been arrested. The video, which came to light sometime last week and has been circulated on social media platforms, depicts inappropriate behaviour involving the girl and multiple boys. The police are urging the public to refrain from sharing the video as they say this can further traumatise the victim and by extension affect the successful outcome of the case. The lawmen are also reminding citizens that sharing such content may constitute a breach of the Child Pornography (Prevention Act), and persons found guilty are subject to imprisonment for up to 20 years. Meanwhile, Gender Minister Olivia Grange and Minister of Education Dr Dana Morris Dixon, in a jointed media statement, have both condemned the incident. Grange said she is outraged and deeply concerned about the sexual assault of the young female student. She said it was a heinous act of violence which demands swift justice for the victim. "This is appalling and despicable and has no place in our society. It shows why as a nation, we must come together to protect our women and girls. It is heartbreaking to see this kind of violence, especially against our children, who should be nurtured and protected in every space they occupy." Grange called for all Jamaicans to take a stand against gender-based violence and emphasised the importance of fostering a culture of respect and safety for women and girls. "It is our collective responsibility to ensure that our children are safeguarded, both physically and emotionally, and that perpetrators of such crimes are held accountable.” For her part, Morris Dixon said this horrifying incident not only highlights the pervasive issue of violence against women and girls but also underscores the urgent need to address this scourge through education, awareness, and enforcement of the law. "The Ministry of Education stands ready to provide counselling and psycho-social support to the student, families and members of the community affected by this traumatic event. This type of violence being perpetuated by students cannot not be tolerated.” Follow The Gleaner on X, formerly Twitter, and Instagram @JamaicaGleaner and on Facebook @GleanerJamaica. Send us a message on WhatsApp at 1-876-499-0169 or email us at onlinefeedback@gleanerjm.com or editors@gleanerjm.com .
Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor. Thus, for over 50 years now, scientists have been on a quest to identify which malignant mutations within the tumor allow rogue cells to break away from the primary tumor and travel through the bloodstream and lymphatic system to metastasize throughout the body. But new research suggests an alternative mechanism has been overlooked—elusive mutations driving metastasis may not be developing within the twisted DNA of tumors themselves, but within the patient's regular, inherited DNA. The findings, published in Cell , provide the first evidence of genetic predisposition to breast cancer metastasis, with far-reaching clinical implications—including a potential therapy that could prevent it. "Metastasis we believe is, at least in part, a hereditary disorder," says Sohail Tavazoie, the Leon Hess Professor at Rockefeller. "We have been so focused on the cancer cells , the 'seeds," that we've ignored the germline—'the soil." It's now clear that focusing on the soil is critical." Root of the problem Although scientists have rigorously investigated metastasis for decades, extensive genomic sequencing of metastatic tumors have come up empty. Patient tumors are full of mutated genes, but none have been shown to specifically drive metastasis. "So, we hypothesized instead that maybe the host's own genetics, not the tumor, is providing those mutations," Tavazoie says. In fact, Tavazoie and colleagues had previously demonstrated that various germline alleles of APOE can enhance or suppress melanoma metastasis. To find out whether breast cancer metastasis operates in a similar manner, the Tavazoie lab dove into human genetics with large patient cohorts from multiple countries. A common variant of the PCSK9 gene immediately caught their attention. Present in the germlines of 70 percent of white women, this gene variant was associated with reduced breast cancer survival. And when the team engineered mice with the relevant variant form of human PCSK9, the rate of metastasis increased. Colleagues at Lund University in Sweden further validated these results with an analysis of a large Scandinavian cohort of early-stage breast cancer patients. Their findings were stark: patients with the PCSK9 variant faced a 22 percent risk of metastasis within 15 years, compared to a 2 percent risk among those without it. "Our results emphasize the importance of international collaboration, which by definition involves researchers and patient cohorts from multiple countries," says Wenbin Mei, a graduate fellow in Tavazoie's lab and lead author on the paper. "Further, this demonstrates just how powerful human genetics has become. With new technologies that combine computational analysis with experimental models, we're in a great era to answer difficult questions." Digging deeper The study also sheds light on how the PCSK9 variant drives metastasis. By degrading the LRP1 receptor on cancer cells, the variant appears to unleash a cascade of gene activation ideal for metastatic initiation. Interestingly, the lab's prior work on melanoma found that the APOE alleles that promote or suppress metastasis also act on LRP1. "It's remarkable that, in two different cancers, the mechanism of metastasis converges on this one receptor," Tavazoie says. Future work from the lab will focus on LRP1's suspiciously consistent role in metastasis. Despite the evidence now linking the PCSK9 variant to metastatic disease, Tavazoie clarifies that patients with this variant should not be alarmed. The data suggests that patients with the variant have a 22 percent risk of metastasis, as compared to a 2 percent risk without the variant. "The majority of patients with early-stage breast cancers harboring either variant will still never develop metastasis," he says. But he now is optimistic about the possibility of reducing metastatic disease among the less fortunate 22 percent. The present study includes preliminary work suggesting that PCSK9 can be suppressed with an antibody that blocks the activity of PCSK9 that is already approved for high cholesterol. "This is a safe and well-tolerated drug," Tavazoie says, while cautioning that clinical trials will be necessary to demonstrate its efficacy in cancer. "Our hope is that high-risk patients with this variant could one day be treated proactively, reducing their chances of metastasis by targeting the specific signals that elicit this outcome." More information: Wenbin Mei et al, A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor, Cell (2024). DOI: 10.1016/j.cell.2024.11.009
STANFORD, Calif. — Andrew Luck is returning to Stanford in hopes of turning around a struggling football program that he once helped become a national power. Athletic director Bernard Muir announced Saturday that Luck has been hired as the general manager of the Stanford football team, tasked with overseeing all aspects of the program that just finished a 3-9 season under coach Troy Taylor. “I am a product of this university, of Nerd Nation; I love this place,” Luck said. “I believe deeply in Stanford’s unique approach to athletics and academics and the opportunity to help drive our program back to the top. Coach Taylor has the team pointed in the right direction, and I cannot wait to work with him, the staff, and the best, brightest, and toughest football players in the world.” Luck has kept a low profile since his surprise retirement from the NFL at age 29 when he announced in August 2019 that he was leaving the Indianapolis Colts and pro football. Cardinal alum Andrew Luck, left, watches a Feb. 2 game between Stanford and Southern California on Feb. 2 in Stanford, Calif. Josie Lepe, AP File In his new role, Luck will work with Taylor on recruiting and roster management, and with athletic department and university leadership on fundraising, alumni relations, sponsorships, student-athlete support and stadium experience. “Andrew’s credentials as a student-athlete speak for themselves, and in addition to his legacy of excellence, he also brings a deep understanding of the college football landscape and community, and an unparalleled passion for Stanford football,” Muir said. “I could not think of a person better qualified to guide our football program through a continuously evolving landscape, and I am thrilled that Andrew has agreed to join our team. This change represents a very different way of operating our program and competing in an evolving college football landscape.” Luck was one of the players who helped elevate Stanford into a West Coast powerhouse for several years. He helped end a seven-year bowl drought in his first season as starting quarterback in 2009 under coach Jim Harbaugh and led the Cardinal to back-to-back BCS bowl berths his final two seasons, when he was the Heisman Trophy runner-up both seasons. Stanford quarterback Andrew Luck throws a pass during the first quarter of a Nov. 27, 2010 game against Oregon State in Stanford, Calif. Paul Sakuma, AP File That was part of a seven-year stretch in which Stanford posted the fourth-best record in the nation at 76-18 and qualified for five BCS bowl berths under Harbaugh and David Shaw. But the Cardinal have struggled for success in recent years and haven't won more than four games in a season since 2018. Stanford just finished its fourth straight 3-9 campaign in Taylor's second season since replacing Shaw. The Cardinal are the only power conference team to lose at least nine games in each of the past four seasons. Luck graduated from Stanford with a bachelor’s degree in architectural design and returned after retiring from the NFL to get his master’s degree in education in 2023. He was picked No. 1 overall by Indianapolis in the 2012 draft and made four Pro Bowls and was AP Comeback Player of the Year in 2018 in his brief but successful NFL career. Before the 2023 National Football League season started, it seemed inevitable that Bill Belichick would end his career as the winningest head coach in league history. He had won six Super Bowls with the New England Patriots and 298 regular-season games, plus 31 playoff games, across his career. Then the 2023 season happened. Belichick's Patriots finished 4-13, the franchise's worst record since 1992. At the end of the year, Belichick and New England owner Robert Kraft agreed to part ways. And now, during the 2024 season, Belichick is on the sideline. He's 26 wins from the #1 spot, a mark he'd reach in little more than two seasons if he maintained his .647 career winning percentage. Will he ascend the summit? It's hard to tell. Belichick would be 73 if he graced the sidelines next season—meaning he'd need to coach until at least 75 to break the all-time mark. Only one other NFL coach has ever helmed a team at age 73: Romeo Crennel in 2020 for the Houston Texans. With Belichick's pursuit of history stalled, it's worth glancing at the legends who have reached the pinnacle of coaching success. Who else stands among the 10 winningest coaches in NFL history? Stacker ranked the coaches with the most all-time regular-season wins using data from Pro Football Reference . These coaches have combined for 36 league championships, which represents 31.6% of all championships won throughout the history of pro football. To learn who made the list, keep reading. You may also like: Ranking the biggest NFL Draft busts of the last 30 years Bettmann/Contributor // Getty Images - Seasons coached: 23 - Years active: 1969-91 - Record: 193-148-1 - Winning percentage: .566 - Championships: 4 Chuck Noll's Pittsburgh Steelers were synonymous with success in the 1970s. Behind his defense, known as the Steel Curtain, and offensive stars, including Terry Bradshaw, Franco Harris, and Lynn Swann, Noll led the squad to four Super Bowl victories from 1974 to 1979. Noll's Steelers remain the lone team to win four Super Bowls in six years, though Andy Reid and Kansas City could equal that mark if they win the Lombardi Trophy this season. Noll was elected to the Pro Football Hall of Fame in 1993, two years after retiring. His legacy of coaching success has carried on in Pittsburgh—the club has had only two coaches (Bill Cowher and Mike Tomlin) since Noll retired. Focus on Sport // Getty Images - Seasons coached: 25 - Years active: 1946-62, '68-75 - Record: 213-104-9 - Winning percentage: .672 - Championships: 7 The only coach on this list to pilot a college team, Paul Brown, reached the pro ranks after a three-year stint at Ohio State and two years with the Navy during World War II. He guided the Cleveland Browns—named after Brown, their first coach—to four straight titles in the fledgling All-America Football Conference. After the league folded, the ballclub moved to the NFL in 1950, and Cleveland continued its winning ways, with Brown leading the team to championships in '50, '54, and '55. He was fired in 1963 but returned in 1968 as the co-founder and coach of the Cincinnati Bengals. His other notable accomplishments include helping to invent the face mask and breaking pro football's color barrier . Bettmann/Contributor // Getty Images - Seasons coached: 33 - Years active: 1921-53 - Record: 226-132-22 - Winning percentage: .631 - Championships: 6 An early stalwart of the NFL, Curly Lambeau spent 29 years helming the Green Bay Packers before wrapping up his coaching career with two-year stints with the Chicago Cardinals and Washington. His Packers won titles across three decades, including the league's first three-peat from 1929-31. Notably, he experienced only one losing season during his first 27 years with Green Bay, cementing his legacy of consistent success. Born in Green Bay, Lambeau co-founded the Packers and played halfback on the team from 1919-29. He was elected to the Hall of Fame as a coach and owner in 1963, two years before his death. You may also like: Countries with the most active NFL players Bettmann/Contributor // Getty Images - Seasons coached: 29 - Years active: 1960-88 - Record: 250-162-6 - Winning percentage: .607 - Championships: 2 The first head coach of the Dallas Cowboys, Tom Landry held the position for his entire 29-year tenure as an NFL coach. The Cowboys were especially dominant in the 1970s when they made five Super Bowls and won the big game twice. Landry was known for coaching strong all-around squads and a unit that earned the nickname the "Doomsday Defense." Between 1966 and 1985, Landry and his Cowboys enjoyed 20 straight seasons with a winning record. He was elected to the Hall of Fame in 1990. Focus on Sport // Getty Images - Seasons coached: 26 - Years active: 1999-present - Record: 267-145-1 - Winning percentage: .648 - Championships: 3 The only active coach in the top 10, Andy Reid has posted successful runs with both the Philadelphia Eagles and Kansas City. After reaching the Super Bowl once in 14 years with the Eagles, Reid ratcheted things up with K.C., winning three titles since 2019. As back-to-back defending champions, Reid and Co. are looking this season to become the first franchise to three-peat in the Super Bowl era and the third to do so in NFL history after the Packers of 1929-31 and '65-67. Time will tell if Reid and his offensive wizardry can lead Kansas City to that feat. Jamie Squire // Getty Images - Seasons coached: 29 - Years active: 1991-95, 2000-23 - Record: 302-165 - Winning percentage: .647 - Championships: 6 The most successful head coach of the 21st century, Bill Belichick first coached the Cleveland Browns before taking over the New England Patriots in 2000. With the Pats, Belichick combined with quarterback Tom Brady to win six Super Bowls in 18 years. Belichick and New England split after last season when the Patriots went 4-13—the worst record of Belichick's career. His name has swirled around potential coaching openings , but nothing has come of it. Belichick has remained in the media spotlight with his regular slot on the "Monday Night Football" ManningCast. Tom Pennington // Getty Images - Seasons coached: 40 - Years active: 1920-29, '33-42, '46-55, '58-67 - Record: 318-148-31 - Winning percentage: .682 - Championships: 6 George Halas was the founder and longtime owner of the Chicago Bears and coached the team across four separate stints. Nicknamed "Papa Bear," he built the ballclub into one of the NFL's premier franchises behind players such as Bronko Nagurski and Sid Luckman. Halas also played for the team, competing as a player-coach in the 1920s. The first coach to study opponents via game film, he was once a baseball player and even made 12 appearances as a member of the New York Yankees in 1919. He was inducted into the Hall of Fame in 1963 as both a coach and owner. Bettmann/Contributor // Getty Images - Seasons coached: 33 - Years active: 1963-95 - Record: 328-156-6 - Winning percentage: .677 - Championships: 2 The winningest head coach in NFL history is Don Shula, who first coached the Baltimore Colts (losing Super Bowl III to Joe Namath and the New York Jets) for seven years before leading the Miami Dolphins for 26 seasons. With the Fins, Shula won back-to-back Super Bowls in 1972 and 1973, a run that included a 17-0 season—the only perfect campaign in NFL history. He also coached quarterback great Dan Marino in the 1980s and '90s, but the pair made it to a Super Bowl just once. Shula was inducted into the Hall of Fame in 1997. Story editing by Mike Taylor. Copy editing by Robert Wickwire. Photo selection by Lacy Kerrick. You may also like: The 5 biggest upsets of the 2023-24 NFL regular season Bettmann/Contributor // Getty Images
Gov Okpebholo suspends free bus services earlier approved for Edo residentsGREEN BAY, Wis. (AP) — Jasin Sinani's 22 points helped Campbell defeat Green Bay 72-66 on Saturday. Sinani had eight rebounds for the Fighting Camels (4-4). Cameron Gregory scored 11 points while shooting 4 for 9, including 1 for 4 from beyond the arc and added seven rebounds. Colby Duggan went 4 of 8 from the field (3 for 6 from 3-point range) to finish with 11 points. Anthony Roy led the Phoenix (2-6) in scoring, finishing with 20 points, nine rebounds and two steals. Marcus Hall added 13 points for Green Bay. Campbell went into halftime ahead of Green Bay 33-27. Sinani put up 12 points in the half. Campbell went on an 18-0 run to take a 51-31 lead with 14:07 left in the half. Sinani scored 10 second-half points. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
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After his team's 102-89 home win on Wednesday night over Purdue Fort Wayne, Penn State coach Mike Rhoades challenged his team's fan base to show up and make more noise. "Sweat with us," he said at one point. At 5-0, the Nittany Lions haven't had to sweat much to get off to a fast start. They might not have to expend much perspiration to make it 6-0 on Monday when they meet Fordham in a semifinal matchup at the Sunshine Slam tournament in Daytona Beach, Fla. Penn State hasn't played a strong schedule so far, but the team has been impressive. It's averaging 98.2 points per game and 13.8 steals per game, both of which ranked second in Division I through Saturday's play. The Nittany Lions were seventh per kenpom.com in turnover rate, forcing 25.3 per 100 possessions. Point guard Ace Baldwin Jr. is leading the charge, scoring 16.4 points and dishing out 7.8 assists while chipping in 2.6 steals. Zach Hicks has nearly doubled his scoring average from 8.4 last season to 15.8 this season, while Northern Illinois transfer Yanic Konan Niederhauser has beefed up the interior, tallying 12.2 points and 7.2 rebounds. Meanwhile, Fordham (3-3) is coming off a 73-71 home loss Friday night against Drexel in New York. The Rams blew a seven-point lead early in the second half and missed a chance to force overtime when leading scorer Jackie Johnson III missed a layup as time expired. Johnson, a UNLV transfer, is averaging 19 points per game and is making nearly 48 percent of his shots as one of three Rams with double-figure scoring averages. Jahmere Tripp scores at an 11.0 clip while Japhet Medor is contributed 10.5, but Fordham is struggling to make shots, canning only 41.5 percent from the field. The Rams were picked for a 14th-place finish in the Atlantic 10 despite returning more scoring than any team in the league except for VCU. Third-year coach Keith Urgo thinks his team can defy low external expectations. "We're experienced and I think we're poised to have a tremendous year," he said. --Field Level MediaArmed Arizona man 'threatened to kill Donald Trump and his family' in series of unhinged videos Manuel Tamayo-Torres posted videos brandishing high-powered weapons CLICK HERE: Sign up for DailyMail.com's daily U.S. politics newsletter Follow DailyMail.com's politics live blog for all the latest news and updates By JON MICHAEL RAASCH, U.S. POLITICAL REPORTER FOR DAILYMAIL.COM Published: 19:32 GMT, 27 November 2024 | Updated: 19:36 GMT, 27 November 2024 e-mail 1 View comments An Arizona man has been arrested after posting numerous videos online brandishing rifles, shotguns and a high-capacity AR-15 while threatening to kill Donald Trump and his children. Manuel Tamayo-Torres posted 'numerous lengthy videos' on Facebook threatening Trump and his family and even attended one of the president-elect's rallies in Arizona, court documents show. 'You're gonna die, your son's gonna die,' Tamayo-Torres said in a scary video posted Thursday. 'Your whole family is going to die.' 'This is reality for you now. This is the only reality you have in your future, dying,' the clip continued. 'Secret Service, FBI , CIA and the military are all defenseless.' Tamayo-Torres was charged with making threats against the president-elect, who is referred to as 'Individual 1' in the court filings. In another video Tamayo-Torres threatens to shoot Trump before holding up 'what appears to be a white AR-15 style rifle with a 30-round magazine inserted into it,' according to officials. The officials also describe in the court filings how the Arizona man made threats 'on a near-daily basis.' Almost everyday Tamayo-Torres posted videos 'where he talks about [Individual 1] and his family kidnapping and sex-trafficking his children.' An Arizona man was arrested for making threats to kill Donald Trump and his family Manuel Tamayo-Torres, who made repeated threats on Trump and his family, was at Trump's August 23 rally in Glendale Arizona, court documents reveal Tamayo-Torres said he witnessed the president-elect and the Secret Service 'kidnap his daughter' at the Glendale rally Even more shockingly, Tamayo-Torres even appeared at a Trump campaign rally in August. A video from August 23 shows Tamayo-Torres at a Trump campaign rally at the Desert Diamond Arena in Glendale, Arizona. In the video the man claims he 'observed [Individual 1] and Secret Service kidnap his daughter there.' Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) officials claim they discovered images on Facebook showing Tamayo-Torres holding a verified arsenal of weaponry. He brandished an AR-15, a rifle and a shotgun in one video, ATF officials claim in the court documents. Tamayo-Torres was arrested in California after videos showed him around the San Diego area, though the charges were filed in Arizona. This is just one of the latest threats made against the president-elect in what has been a tumultuous year for his personal safety. While visiting a section of the U.S.-Mexico border wall in Arizona in August, DailyMail.com tipped off Trump that another Arizona man who had made death threats against the Republican was on the loose. Republican presidential nominee former President Donald Trump tours the southern border with Mexico, Thursday, Aug. 22, 2024, in Sierra Vista, Arizona Ronald Lee Syvrud, 66, is being sought by Arizona authorities in connection with an alleged assassination plot on Donald Trump Trump thanked DailyMail.com for letting him know, saying 'Thank you for telling me.' Then with a chuckle he said: ' Let's get out of here right now!' It was a surprisingly chipper response just over a month after the first attempt on his life. Notoriously Trump was shot in the ear during a July 13 campaign rally in Butler, Pennsylvania. Shooter Thomas Matthew Crooks struck the president and several others, killing father Corey Comperatore as he shielded his family from incoming fire. Crooks was killed by Secret Service shortly after opening fire with an AR-15. The horrific rally prompted a review of the Secret Service, and soon thereafter its ex-director, Kimberly Chealte, resigned after getting ridiculed by Democrats and Republicans in Congress for the innumerable security failures that day. Again on September 15 Trump was targeted by another would-be assassin. Secret Service counter snipers keep watch during a campaign rally with Donald Trump Ryan Wesley Routh following his arrest in Martin County, Florida, on September 15. The gunman accused of planning to kill Donald Trump at his Florida golf course was indicted September 24, 2024 on three additional counts, including attempted assassination of a major presidential candidate Ryan Routh, 58, hid in the hedges near Trump's West Palm Beach golf course Trump International with an AK-47 and cameras before fleeing after being fired upon by Secret Service. Routh is currently being held in a federal detention center in Miami. Earlier this month, the Justice Department announced charges in an alleged Iranian plot to try to kill Trump. Donald Trump Arizona Share or comment on this article: Armed Arizona man 'threatened to kill Donald Trump and his family' in series of unhinged videos e-mail Add commentNone