top 646 jili
AMMAN: Syrian rebels battled government forces for control of the key city of Homs on Saturday (Dec 7) and advanced towards the capital Damascus as front lines collapsed across the country, throwing President Bashar al-Assad's 24-year rule into the balance. Since the rebels' sweep into Aleppo a week ago , government defences have crumbled at dizzying speed as insurgents seized a string of major cities and rose up in places where the rebellion had long seemed over. The twin threats to strategically vital Homs and the capital Damascus now pose an existential danger to the Assad dynasty's five-decade reign over Syria and the continued influence there of its main regional backer Iran. A Homs resident, and army and rebel sources said the insurgents had breached government defences from the north and east of the city. A rebel commander said they had taken control of an army camp and villages outside the city. State television reported that the insurgents had not penetrated into Homs although it said they were on the city outskirts, where it said the military was striking them with artillery and drones. Insurgents have seized almost the entire southwest within 24 hours, and they have advanced to within 30 km (20 miles) of Damascus as government forces fell back, rebels said. Underscoring the possibility of an uprising in the capital, protesters took to the streets in several Damascus suburbs, ripping up Assad posters and tearing down a statue of his father, former President Hafez al-Assad, uncontested by army or police. Some were joined by soldiers who had changed into civilian clothes and deserted, residents said. However, the state news agency reported that Assad remains in Damascus, and the military said it was reinforcing around the capital and south. The pace of events has stunned Arab capitals and raised fears of a new wave of regional instability. Syria's civil war, which erupted in 2011 as an uprising against Assad's rule, dragged in big outside powers, created space for jihadist militants to plot attacks around the world and sent millions of refugees into neighbouring states. Assad had long relied on allies to subdue the rebels. Russian warplanes conducted bombing while Iran sent allied forces including Lebanon's Hezbollah and Iraqi militia to reinforce the Syrian military and storm insurgent strongholds. But Russia has been focused on the war in Ukraine since 2022 and Hezbollah has suffered big losses in its own gruelling war with Israel, significantly limiting its ability or that of Iran to bolster Assad. US President-elect Donald Trump said the US should not be involved in the conflict and should "let it play out". RUSSIA, IRAN, TURKEY The foreign ministers of Russia, Iran and the rebels' main backer Turkey met on Saturday and agreed on the importance of Syria's territorial integrity and on restarting a political process, they said. But there was no indication they agreed on any concrete steps, with the situation inside Syria changing by the hour. Russia has a naval base and airbase in Syria that have not only been important for its support of Assad, but also for its ability to project influence in the Mediterranean and Africa. Moscow has been supporting government forces with intense air strikes but it was not clear if it could easily step up this campaign. Iran has said it would consider sending forces to Syria, but any immediate extra assistance would likely depend on Hezbollah and Iraqi militias. The Lebanese group sent some "supervising forces" to Homs on Friday but any significant deployment would risk exposure to Israeli airstrikes, Western officials said. Iran-backed Iraqi militias are on high alert, with thousands of heavily armed fighters ready to deploy to Syria , many of them amassed near the border. Iraq does not seek military intervention in Syria, a government spokesman said on Friday. Britain warned Assad that any chemical weapons use was a red line and would be met with "appropriate action". A rebel operations room led by the main rebel group, the militant Hayat Tahrir al-Sham, a former al Qaeda affiliate, said in a statement that it has no intention of using chemical weapons now controlled by Syrian authorities "under any circumstances". BATTLE FOR HOMS The Homs resident said he had seen the rebels advance past a Syrian Air Force base in the north of the city that was considered a major defensive area. The resident later said fighting was audible in the city outskirts. An opposition figure in touch with rebel command and a Syrian army source both also said the insurgents were inside the city. Seizing Homs, an important crossroads between the capital and the Mediterranean, would cut off Damascus from the coastal stronghold of Assad's minority Alawite sect, and from Russia's air and naval base. In the south, the rapid collapse of government control could allow a concerted assault on the capital, the seat of Assad's power, where residents said electricity cut out on Saturday. The Syrian military pulled back as far as Saasa, 30 km (20 miles), from Damascus to regroup, a Syrian army officer said. In the city's southern suburb of Jarmana, protesters pulled down a statue of Hafez al-Assad, the president's father. Soldiers were deserting in the former rebel stronghold of Daraya and in Mezzeh, near a major airbase, residents said. Hayat Tahrir al-Sham said it had a duty to protect governmental, international and UN offices in Syria. In a sign of government forces' collapse in the east, around 2,000 Syrian soldiers crossed the border into Iraq to seek sanctuary, the mayor of Iraqi border town al-Qaem said. Syrian Kurdish fighters captured eastern Deir el-Zor on Friday, jeopardising Assad's land connection to allies in Iraq.Tweet Facebook Mail Radio icon Ray Hadley has bid an emotional farewell to the airwaves, capping a 43-year career in a lengthy interview with fellow 2GB host Ben Fordham. The pair took calls from Hadley's huge audience of listeners, including Sue from the Gold Coast, who said she had been listening to Hadley's "cheeky sense of humour" for 25 years. "I don't know if I'll ever receive a nicer phone call in my life", Hadley said after. READ MORE: Millions brace for scorching heat with mercury tipped to hit 40s The wide-ranging conversation between Fordham and Hadley also saw them discussing his career. "What you've got to be confident in, is your own ability, and the ability of your colleagues," he said. "My best focus group is between my ears." READ MORE: Little girl floats alone for three days after shipwreck Ray Hadley on air in his studio. (Supplied) He recalled bringing the topic of confronting child sex abuse to the airwaves, saying he was initially told people didn't want to hear that on the radio. "Well, that's why I'm doing it," he remembered replying. Hadley, 70, also shared some memories of his late mother Elsie, including her meeting with then-NSW Premier Bob Carr as the president of a local war widows association. READ MORE: McDonald's employee who called 911 in CEO's shooting eligible for reward Long quest for vanished dictator ends View Gallery The elder Hadley apparently told Carr if he didn't agree to their demands, she would go straight to her son. "I rang her up and said ... 'Mum, you cannot threaten the premier of NSW with the fact that I'm your son'," he said. "She said, 'well, it worked, because he gave us everything we wanted'." You can listen to the full interview in the embedded player above. DOWNLOAD THE 9NEWS APP : Stay across all the latest in breaking news, sport, politics and the weather via our news app and get notifications sent straight to your smartphone. Available on the Apple App Store and Google Play . DK Metcalf is happy to block as Seahawks ride streak into Sunday night matchup with Packers
REDWOOD CITY, Calif., Dec. 05, 2024 (GLOBE NEWSWIRE) -- Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for patients with RAS-addicted cancers, today announced the closing of its underwritten public offering of 16,576,088 shares of its common stock at a public offering price of $46.00 per share, before underwriting discounts and commissions, and, in lieu of shares of common stock, to certain investors, pre-funded warrants to purchase 2,173,917 shares of common stock at a public offering price of $45.9999, which represents the per share public offering price for the common stock less the $0.0001 per share exercise price for each pre-funded warrant. The shares of common stock issued and sold in the offering include 2,445,652 shares issued upon exercise in full by the underwriters of their option to purchase additional shares of common stock at the public offering price, less underwriting discounts and commissions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Revolution Medicines, were $862.5 million. All shares and pre-funded warrants in the offering were offered by Revolution Medicines. J.P. Morgan, TD Cowen, Goldman Sachs & Co. LLC and Guggenheim Securities acted as joint book-running managers for the offering. UBS Investment Bank acted as lead manager. A shelf registration statement relating to these securities was filed with the U.S. Securities and Exchange Commission (SEC) on March 4, 2024, and automatically became effective upon filing. This offering was made solely by means of a prospectus. A copy of the final prospectus supplement and the accompanying prospectus relating to this offering may be obtained for free by visiting EDGAR on the SEC’s website at www.sec.gov. Alternatively, a copy of the final prospectus supplement and the accompanying prospectus relating to this offering may be obtained by contacting: J.P. Morgan Securities LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, New York 11717, by email at prospectus-eq_fi@jpmchase.com and postsalemanualrequests@broadridge.com; TD Securities (USA) LLC, 1 Vanderbilt Avenue, New York, New York 10017, by telephone at (855) 495-9846 or by email at TD.ECM_Prospectus@tdsecurities.com; Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, by telephone at (866) 471-2526 or by email at prospectus-ny@ny.email.gs.com; and Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison Avenue, 8th Floor, New York, New York 10017, by telephone at (212) 518-9544 or by email at GSEquityProspectusDelivery@guggenheimpartners.com. This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction. About Revolution Medicines, Inc. Revolution Medicines is a clinical-stage oncology company developing novel targeted therapies for RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors RMC-6236, a RAS(ON) multi-selective inhibitor, RMC-6291, a RAS(ON) G12C-selective inhibitor, and RMC-9805, a RAS(ON) G12D-selective inhibitor, are currently in clinical development. Additional development opportunities in the company’s pipeline focus on RAS(ON) mutant-selective inhibitors, including RMC-5127 (G12V), RMC-0708 (Q61H) and RMC-8839 (G13C), in addition to RAS companion inhibitors RMC-4630 and RMC-5552. Revolution Medicines Investors & Media Contacts: investors@revmed.com; media@revmed.comShould the U.S. increase immigration levels for highly skilled workers?
The Liberal government is pulling out the federal wallet to put more money into people’s pockets over the holidays, but its recently announced affordability measures create winners and losers. Prime Minister Justin Trudeau announced on Thursday that the federal government will remove the goods and services tax on a slew of items for two months, starting Dec. 14. But in provinces where the provincial and federal sales taxes are blended together into a harmonized sales tax, Canadians will get a larger break. The federal government also plans to send $250 cheques to Canadians who were working in 2023 and earned up to $150,000. That means Canadians who were not working in 2023, including those who were receiving social assistance or were in retirement, will not be sent a cheque in April. In the House of Commons on Friday, NDP MP Peter Julian called the government out for not including Canadians with fixed incomes. “Why are Liberals excluding seniors and people with disabilities from the real help they need this holiday season? Why won’t Liberals help them, too?” Julian asked during question period. At a news conference on Friday, Trudeau said that the federal government has already stepped up to help the most vulnerable Canadians and that it is now time to give a hand to workers. “Over the past number of years, we have been extraordinarily present in helping the most vulnerable Canadians,” Trudeau said, mentioning the boost to old-age security for seniors aged 75 and older and the Canada Child Benefit. “But as I travel across the country, I do regularly hear from working Canadians who are having trouble making ends meet, but saying, ‘look, I don’t have kids. I’m not a senior yet, and I’m facing challenges.’” The GST break, which is expected to cost the federal government $1.6 billion, will apply to a number of items including children’s clothing and shoes, toys, diapers, restaurant meals and beer and wine. It also applies to Christmas trees — both natural and artificial — along with a variety of snack foods and beverages, and video game consoles. Meanwhile, 18.7 million people will receive a check this spring, costing the government about $4.7 billion.
The Eagles are looking to clinch the NFC East title while completing a rare sweep of the rival Dallas Cowboys on Sunday in Philadelphia. The Eagles (12-3) will have to play without starting quarterback Jalen Hurts, who sustained a concussion during last weekend's 36-33 loss at Washington that snapped their team-record 10-game winning streak. He was ruled out on Friday after missing practice all week. Backup quarterback Kenny Pickett suffered a rib injury against the Commanders, but he was a full participant at Thursday's practice and was limited on Friday. Pickett is expected to start, with Tanner McKee his backup on Sunday as Philadelphia tries to sweep Dallas for the first time since 2011. Meanwhile, the Cowboys (7-8) are clicking with their own QB2 at the controls. Cooper Rush has guided Dallas to wins in four of the last five games, throwing nine touchdown passes and just one interception in that span. The Cowboys are in the unfamiliar position of playing spoiler, missing the playoffs for the first time since 2020. Two more wins would give Dallas its fourth straight winning season under fifth-year coach Mike McCarthy. "It's hard to win games in this league. It's definitely an end goal just to have a winning season," Cowboys right guard Brock Hoffman said. "... But definitely where we've been at on this journey, take it week by week, win these last two games, have a winning season, and it's definitely a big boost going into next season." The Eagles cruised to a 34-6 win over the Cowboys in Arlington, Texas, in the first meeting in Week 10, with Hurts throwing two touchdown passes and rushing for two scores. Rush finished with just 45 yards on 13-of-23 passing. Pickett replaced a woozy Hurts in the first quarter against Washington and finished the drive with a touchdown pass to A.J. Brown. "I thought it was so cool for our guys to have the confidence in (Pickett) to just hop in there and handle a third down, handle another completion, throw a third-down touchdown in the red zone," Eagles offensive coordinator Kellen Moore said Tuesday. "I thought that was a really cool moment." A sixth-round pick out of Stanford in 2023, McKee has yet to appear in a regular-season game. "I feel like I've always been preparing to be the starter and preparing to play, and so my preparation is going to stay the same," McKee said Tuesday. "And you know, I'm obviously excited for any opportunity that I do get, but we're going to take it day by day for those guys." No matter who plays QB, the Eagles likely will lean heavily on Saquon Barkley. With a league-leading 1,838 rushing yards, he needs 268 in the last two games to break Eric Dickerson's 1984 NFL single-season record of 2,105. Philadelphia's injury report Friday also included the team ruling out wide receiver Britain Covey (neck), who also returns punts, and running back Will Shipley (concussion), a contributor on kickoff return duty. Linebacker Nakobe Dean (abdomen) is doubtful after limited participation on Friday, while defensive end Bryce Huff (wrist) was a full participant and listed as questionable. He would need to be activated from injured reserve to play on Sunday. The Cowboys have shut down star wideout CeeDee Lamb for the rest of the season because of a sprained right shoulder. Also ruled out for Sunday are cornerbacks Kemon Hall (hamstring) and Amani Oruwariye (foot). Guard TJ Bass (thigh) is doubtful, while those with questionable status are wide receivers Jalen Brooks (knee) and Jalen Tolbert (finger), offensive tackles Chuma Edoga (toe) and Asim Richards (ankle), linebackers Eric Kendricks (calf) and Nick Vigil (foot), and safety Donovan Wilson (knee). --Field Level Media
An Israeli strike has killed at least 30 Palestinians and wounded 50 others who were sheltering in a post office in central Gaza Strip, bringing the death toll on Thursday in the enclave to 66. or signup to continue reading With no sign of let-up in the 14-month-old conflict, the strike hit a postal facility in Nuseirat camp where displaced families had sought refuge and also damaged several nearby houses, medics told Reuters. The Israeli military did not immediately respond to a request for comment. Nuseirat is one of the Gaza Strip's eight historic camps originally for Palestinian refugees from the 1948 war around the establishment of Israel. Today, it is part of a dense urban area crowded with displaced people from throughout the enclave. Earlier on Thursday, two Israeli strikes in southern Gaza killed 13 Palestinians who Gaza medics and Hamas said were part of a force protecting humanitarian aid trucks. Israel's military said they were Hamas militants trying to hijack the shipment. Many of those killed in the attacks on Rafah and Khan Younis had links to Hamas, according to sources close to the group. The Israeli military said in a statement the two air strikes aimed to ensure the safe delivery of humanitarian aid and accused Hamas members of planning to prevent the aid from reaching Gaza civilians who need it. The statement said the Hamas members aimed to hijack the aid "in support of continuing terrorist activity". Armed gangs have repeatedly hijacked aid trucks, and Hamas has formed a task force to confront them. The Hamas-led forces have killed over two dozen members of the gangs in recent months, Hamas sources and medics said. Hamas said Israeli military strikes have killed at least 700 police tasked with securing aid trucks in Gaza since the war began on October 7, 2023. It has accused Israel of trying to protect looting and "creating anarchy and chaos to prevent aid from reaching the people of Gaza". Separately, the Israeli military on Thursday ordered residents of several districts in the heart of Gaza City to evacuate, saying it would respond to rockets launched from those areas. "This is a pre-warning before an attack," read a military statement posted on X that some residents also received as text and audio alerts on their mobile phones. The evacuation orders caused a new wave of displacement. At nightfall, dozens of families streamed out of the areas heading toward the centre of the city. Israeli bombings of a residential building in Gaza City's al-Jalaa Street and a house west of Nuseirat killed 22 people, medics and the Palestinian news agency WAFA said. In the northern Gaza refugee camp of Jabalia, where the army has operated since October, health officials said an orthopaedic doctor, Saeed Judeh, was shot dead by Israeli forces while on his way to Al-Awda Hospital where he usually treated patients. The health ministry said his death raised to 1057 the number of healthcare workers killed since the war began. Months of ceasefire efforts by Arab mediators, Egypt and Qatar, backed by the United States, have failed to conclude a deal between the two warring sides. On Wednesday, the United Nations General Assembly overwhelmingly voted to demand an immediate, unconditional and permanent ceasefire and the immediate release of all hostages seized in Israel in October 2023 and held by Hamas in Gaza. The war in the Palestinian enclave began after Hamas gunmen stormed into Israeli communities, killing around 1200 people and taking about 250 hostages back to Hamas-run Gaza, according to Israeli tallies. Since then, Israel's military has levelled swathes of Gaza, driving nearly all of its 2.3 million people from their homes, giving rise to deadly hunger and disease and killing more than 44,800 people, according to Palestinian health authorities. DAILY Today's top stories curated by our news team. WEEKDAYS Grab a quick bite of today's latest news from around the region and the nation. WEEKLY The latest news, results & expert analysis. WEEKDAYS Catch up on the news of the day and unwind with great reading for your evening. WEEKLY Get the editor's insights: what's happening & why it matters. WEEKLY Love footy? We've got all the action covered. WEEKLY Every Saturday and Tuesday, explore destinations deals, tips & travel writing to transport you around the globe. WEEKLY Going out or staying in? Find out what's on. WEEKDAYS Sharp. Close to the ground. Digging deep. Your weekday morning newsletter on national affairs, politics and more. TWICE WEEKLY Your essential national news digest: all the big issues on Wednesday and great reading every Saturday. WEEKLY Get news, reviews and expert insights every Thursday from CarExpert, ACM's exclusive motoring partner. TWICE WEEKLY Get real, Australia! Let the ACM network's editors and journalists bring you news and views from all over. AS IT HAPPENS Be the first to know when news breaks. DAILY Your digital replica of Today's Paper. Ready to read from 5am! DAILY Test your skills with interactive crosswords, sudoku & trivia. Fresh daily! Advertisement AdvertisementTrump names Andrew Ferguson as head of Federal Trade Commission to replace Lina Khan
Women more likely to need walking aids but less likely to use them – studyCaves of Qud is leaving Early Access (and Earth’s gravity) in this poetic new launch trailer
Sony’s cloud streaming makes the PlayStation Portal far more usefulCenk Uygur Tells Brian Tyler Cohen He’s ‘Wrong’ About Trump Supporters Having ‘No Long-Standing Principles’