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NoneNovember 26, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Andreas Rothe, Institute of Science and Technology Austria Virus. When you hear the word, you probably shudder. But not all viruses are bad or cause disease. Some are even used for therapeutic applications or vaccination. In basic research, they are often employed to infect certain cells, genetically modify them, or visualize neurons in the organism's central nervous system (CNS)—the command center made up of the brain, spinal cord, and nerves. The highlighting process now finally works in amphibians. This has been shown in a new study published in Developmental Cell by an international EDGE consortium jointly led by the Sweeney Lab at the Institute of Science and Technology Austria (ISTA) and the Tosches Lab at Columbia University. The researchers established a new technique that uses adeno-associated viruses (AAVs) to track a frog's nervous system throughout its metamorphosis—a developmental transition from the early tadpole stages to its adult form. A breakthrough that can help usher amphibian neurobiology into a new era. Swimming vs. walking David Vijatovic and Lora Sweeney enter a laboratory full of water tanks. Vijatovic taps on one of them. Inside, a small mottled greenish-brown African clawed frog (Xenopus laevis) appears. Its limbs are prominent, gracefully maneuvering and gripping its surroundings. In another tank, tadpoles are swirling around using simple swimming motions. It is remarkable to think that one transforms into the other. "Frogs undergo metamorphosis," Sweeney says, "making them a great model organism for studying the transition between two movement modes—swimming and walking." A frog's development spans over 12 to 16 weeks, giving scientists time to study each stage. During these weeks, a frog embryo develops to a young tadpole, a tadpole with two legs, and a young froglet with four legs before reaching the adult stage. "By looking at the several stages of development, we can investigate these locomotive behaviors and the underlying changes in the nervous system," Vijatovic adds. Just like an electrical circuit: How frogs are wired An organism's nervous system is referred to as the neural circuit because it resembles an electrical circuit . "Nerve cells (neurons) are connected to other neurons, transmitting electrical information. How we behave, what we sense, and how we interact with the world are the product of the way our neurons communicate with each other within these circuits," explains Sweeney. The critical piece is how the circuit is wired. We know that neurons are connected but which neuron connects to which? Which other cells does a single cell talk to, and what messages does it convey? To learn more about this wiring, researchers have been using viruses, proven to be a powerful tool. Adeno-associated viruses (AAVs) are ideal in that regard. They are non-pathogenic while being able to infect a wide range of cell types, including neurons. AAVs can be modified to glow in bright green fluorescent colors under the microscope as they travel along neurons, whether in retrograde (backward, from the synapse toward the cell body) or anterograde (forward, from the cell body toward the synapse). In other words, AAVs can be used to illuminate the neural circuit from the broadcasting end to the receiving end or vice-versa. "This is a common technique used in neuroscience, especially in well-studied organisms like mice. For amphibians, it was thought that it could not be done," says Vijatovic. That was the general belief until now. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . The power of scientific collaboration To make AAV labeling work in amphibians, Sweeney and Vijatovic joined forces with an international team of scientists from Maria Tosches' group at Columbia University, where the study's other two co-first authors Eliza Jaeger and Astrid Deryckere are based. The consortium also included researchers from Tel Aviv University, the University of Utah, the Scripps Research Institute, and the California Institute of Technology. The researchers put their heads together, drew expertise from each other, visited conferences, had countless Zoom calls, and came up with different perspectives and ideas. "When you start researching an organism that is not yet well understood, it is great to have a community where you can share information," says Sweeney. They screened existing AAVs to find what was suitable for amphibians and optimized the infecting strategy eventually developing a "how-to guide" for frogs and newts. Vijatovic summarizes his Ph.D. journey, "We started with young tadpoles, made our way to older tadpoles, and finally moved to juvenile and then adult frogs as well as adult newts. We tailored the tool to each life stage." Comparing frogs to humans: What this research says about us With this new technique, the scientists managed to apply AAVs for tracing neuron connections in amphibians. This will help them find out more about how the amphibian brain compares to that of mammals. Besides that, the new approach also opens doors to further analyzing neuronal development. With some of the screened AAV variants, the researchers can label progenitor cells at a specific point in time during the circuit's development and follow them to see what neurons they become. "This way, we can resolve the whole circuit by its development, see how it changes over time, and how the whole nervous system is built," Sweeney says. Although amphibians and mammals last shared a common ancestor about 360 million years ago, they share common traits. "By comparing the details of a frog's nervous system to a human's, we can see what we don't have and what we have," Sweeney continues. This knowledge can help us understand how the human nervous system became specialized over time. "The better we understand the basic building blocks of the nervous system, the more we understand how we can replace them during disease and injury." More information: Eliza C.B. Jaeger et al, Adeno-associated viral tools to trace neural development and connectivity across amphibians, Developmental Cell (2024). DOI: 10.1016/j.devcel.2024.10.025 Journal information: Developmental Cell Provided by Institute of Science and Technology AustriaIngram Micro Holding Corp. (NYSE:INGM) Receives Consensus Rating of “Moderate Buy” from Brokerages
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Trump asks Supreme Court to delay TikTok ban so he can weigh in after he takes officeThailand remains a top target for cyberthreats and financial phishing attacks among the countries of Southeast Asia, according to global cybersecurity company Kaspersky. During the first six months of 2024, Kaspersky blocked more than 23 million bruteforce attacks targeting businesses in Southeast Asia. A bruteforce attack is a method employed by cybercriminals to guess login info, encryption keys, or to find a hidden web page by systematically attempting all possible character combinations until they find the correct one. It allows attackers to obtain personal data and other valuable information, plant and spread malware, and even hijack a system for malicious activities. A total of 23,491,775 bruteforce generic Remote Desktop Protocol (RDP) attacks were detected and foiled by Kaspersky products installed at companies of various sizes in the region. RDP is Microsoft's proprietary protocol, providing a user with a graphical interface to connect to another computer via a network. Vietnam, Indonesia and Thailand registered the highest number of RDP attacks during the first half of the year, with over 8.4 million, 5.7 million and 4.2 million attacks recorded, respectively. Moreover, Kaspersky detected 336,294 phishing attacks launched at organisations and businesses in Southeast Asia. The attacks were impersonating e-commerce, banking and payment brands, and were aimed at stealing credentials and other sensitive data. Thailand logged the highest number of financial phishing attacks at 141,258, followed by Indonesia with 48,439. Thailand and Singapore both registered the two largest increases of such attacks of 582% and 406%, respectively, compared to the corresponding period last year. Through financial phishing, attackers deceptively manipulate victims to divulge their personal and valuable information such as login credentials to financial accounts, as well as other personal or corporate information that is stored in those accounts. They are employing advanced social engineering schemes masquerading as financial institutions to deceive, invoke fear and exhort victims, and in some instances impersonating charitable organisations to trick victims into making contributions. Adrian Hia, managing director for Asia-Pacific at Kaspersky, earlier told the Bangkok Post that the company has committed to significant investment in Thailand as a growing digital economy and favourable government initiatives such as joining Brics. Brics is a bloc of major emerging economies, comprising Brazil, Russia, India, China, South Africa, the United Arab Emirates, Iran, Egypt and Ethiopia as full members. This has led Kaspersky to expand its team and services, targeting both the small and medium-sized enterprise and enterprise sectors. Thailand is expected to play a pivotal role in the company's APAC expansion, potentially becoming one of its top five markets by 2026, Mr Hia said. "We're committed to doubling our investment in the country over the next two years," he said. He added that the geopolitical landscape is seen as both a challenge and an opportunity. While there are "good" and "not-so-good" markets for the company, the favourable environment in Thailand, especially with the government's digital initiatives, provides an optimistic outlook. These initiatives include the promotion of digital currency, the widespread adoption of cryptocurrencies, and digital services that fuel the digital transformation of the economy. Mr Hia also sees opportunities in SIEM (Security Information and Event Management), as solutions are becoming increasingly important as businesses need to store and analyse security incidents.
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HAUPPAUGE, N.Y., Nov. 26, 2024 (GLOBE NEWSWIRE) -- AmpliTech Group, Inc. (Nasdaq: AMPG, AMPGW) (the “Company”), a designer, developer, and manufacturer of state-of-the-art signal processing components for satellite, Public and Private 5G, and other communications networks, including the design of complete 5G/6G systems and a global distributor of packages and lids for integrated circuits assembly, today announced it has closed on its previously announced registered direct offering for the sale of 1,603,259 shares of common stock (or pre-funded warrants in lieu thereof) (“the Securities”) at an offering price of $0.92 per share. The gross proceeds to the Company from the registered direct offering were approximately $1,475,000 before deducting the placement agent’s fees and other offering expenses. Maxim Group LLC acted as the sole placement agent in connection with the offering. The Securities were offered pursuant to a shelf registration statement on Form S-3 (File No. 333-278657), which was declared effective by the U.S. Securities and Exchange Commission (the “SEC”) on April 24, 2024. The offering was made only by means of a prospectus supplement that forms a part of such registration statement. This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these Securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction. A prospectus supplement relating to the Securities offered in the registered direct offering was filed by the Company with the SEC. Copies of the prospectus supplement relating to the registered direct offering, together with the accompanying prospectus, can be obtained at the SEC's website at www.sec.gov or from Maxim Group LLC, 300 Park Avenue, New York, NY 10022, Attention: Syndicate Department, or via email at syndicate@maximgrp.com or telephone at (212) 895-3500. About AmpliTech Group AmpliTech Group, Inc., comprising five divisions—AmpliTech Inc., Specialty Microwave, Spectrum Semiconductors Materials, AmpliTech Group Microwave Design Center, and AmpliTech Group True G Speed Services is a leading designer, developer, manufacturer, and distributor of cutting-edge radio frequency (RF) microwave components and 5G network solutions. Serving global markets, including satellite communications, telecommunications (5G & IoT), space exploration, defense, and quantum computing, AmpliTech Group is committed to advancing technology and innovation. Forward-Looking Statements All statements in this release that are not based on historical fact are “forward-looking statements” including within the meaning of the Private Securities Litigation Reform Act of 1995 and the provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The information in this announcement may contain forward-looking statements and information related to, among other things, statements regarding the Company, its business plan and strategy, and its industry. Such forward statements include, but are not limited to, that the booking of orders and anticipation of booking of orders, including LNB and 5G products and Fujitsu Spain, will lead to sales of products, These statements reflect management’s current views with respect to future events based on information currently available and are subject to risks and uncertainties that could cause the Company’s actual results to differ materially from those contained in the forward-looking statements, including risks related to market conditions, and other risks described in the Company’s filings with the SEC. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date on which they are made. The Company does not undertake any obligation to revise or update these forward-looking statements to reflect events or circumstances after such date or to reflect the occurrence of unanticipated events. Contacts: Corporate Social Media Twitter: @AmpliTechAMPG Instagram: @AmpliTechAMPG Facebook: AmpliTechInc Linked In: AmpliTech Group Inc Investor Social Media Twitter: @AMPG_IR StockTwits: @AMPG_IR Company Contact: Jorge Flores Tel: 631-521-7831 Investors@amplitechgroup.com
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NoneChairman of NPP UK chapter, Kingsley Adumattah Agyapong The Chairman of the New Patriotic Party(NPP)UK chapter, Kingsley Adumattah Agyapong, commonly known as Wofa K, has claimed that the Akufo-Addo-led administration is leaving behind a strong economy. He argued that the incoming Mahama-led administration should have no excuse to send the country back to the dark days. “If Mahama fails to build on the growth we have achieved, the growth rate will drop and the country will head back to the challenges and difficulties we complained about,” he said. He asserted that Mr Mahama has a poor track record of mismanaging the economy, and the example could be traced to when the Atta Mills increased our GDP from 8% under Kufuor to 14%, which dropped to 3.5%. Mahama destroyed all the gains made and plunged us into five years of dumsor with the collapse of industries, which cost the country an annual figure of GHC 10.88 billion. That was the state of the country. He added the NPP came in with every fibre in us and worked hard; in 2017, 2018, and 2019, Ghana was the fastest-growing economy in the whole world. If not for the outbreak of Covid-19, we would have experienced something different. He stressed the need for Mahama not to have any excuse but to put in motion all his promises to make the living conditions of the people better than what the NPP had done
A Michigan man now has a college fund for his children thanks to work by Iowa Treasurer Roby Smith and State Rep. Mike Vondran, who helped reunite him with more than $317,000 in lost property. Smith and Vondran marked the found funds with an event at the Scott County Treasurer's Office Tuesday morning. The connection was made as part of the Great Iowa Treasure Hunt . Each year, millions of dollars are turned over to the state treasurer for safekeeping after financial institutions and businesses lose contact with the owner. Every effort is made to return the assets back to the rightful owner or their heirs. Examples include dormant checking and savings accounts, uncashed checks, lost stocks and bonds, utility security refunds and insurance benefits, according to a news release. People are also reading... Smith said he gave Vondran a list of the top 100 people in his district with unclaimed property. This was by far the largest amount, Vondran said. "Mine range from a low of $12,000 to a high of $317,000. It's an amazing thing when you find these resources, these legacies have just kind of disappeared on people and they wind up here," Vondran said. "These dollars have to go somewhere, by law, so they wind up in this account, and many people just lose track of things." The check presented on Tuesday was a result of a family member passing and their assets getting lost in the process, he said. "This individual's legacy was sitting in the account without an attachment to family and heirs, and we were able to find the single heir," he said. But, there was a catch. When Vondran called the heir — a man named Robert who resides in Michigan — Robert thought it was all a lie. "(Robert) actually called me one day out of the blue, after me leaving repeated messages, and said, 'Hey, I'm so sorry. I thought it was a scam. I was actually traveling through the Quad-Cities ... visiting with family, and referenced this and said, 'You can't believe what just happened to me,''" Vondran recounted. "And his distant cousin said, 'Well, I know Mike. He's my representative.' And then we called and made the connection." Vondran sent over the proper paperwork and in less than two weeks, Robert, who was not present Tuesday, was united with the lost family money, which he plans to use for his children's college fund, Vondran said. "It's a great story, and it's one of the largest (returns) in the history of Scott County," Smith said. "We gave out a record number last year, almost $35 million was the record in the history of Iowa, that we've given back. And the top amount was around the $4 million but I can tell you, as part of the history, this is up there for Scott County." The state has more than $566 million it is looking to return to its rightful owners, Smith said. Anyone who would like to search for a claim can go to www.greatiowatreasurehunt.gov and type in their information. Illinois residents can search a similar program in their state at icash.illinoistreasurer.gov . Iowa's Lucy Olsen and Taylor Stremlow discuss the Hawkeyes' win over Washington State in Iowa City at Carver-Hawkeye Arena on Sunday, Nov. 24. (Ethan Petrik/Quad-City Times) Photos: Quad City Arts Festival of Trees Parade and opening of Festival of Trees Exchange students visiting the Quad-Cities through the Rotary Young Exchange of the Moline Rotary got to see the 32nd annual Quad City Arts Festival of Trees Holiday Parade and partake in the 39th annual Festival of Trees at the Davenport RiverCenter. Former KWQC TV personality Paula Sands waves to the crowd. Sands was Parade Marshal for Channel 6. Santa and Mrs. Claus wave to the crowd during the 32nd annual Quad City Arts Festival of Trees Parade in downtown Davenport on Saturday. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. Arts for the kids is one of the many attractions this year at the Quad City Arts Festival of Trees being held through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. Kids play in the globe at the Quad City Arts Festival of Trees which opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. The Quad City Arts Festival of Trees opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. Braelynn Armstrong, 4, holds onto her mother's hand as she tells Santa her Christmas wishes from a distance. Santa will be hearing wishes during the 39th annual Quad City Arts Festival of Trees that opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. Bentley Armstrong, 11 months, sits quietly on Santa's lap on Saturday during the 39th annual Quad City Arts Festival of Trees that opened Saturday and runs through Dec. 1 at the Davenport RiverCenter. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Davenport Police Sgt. Eric Gruenhagen watches the route of the 32nd annual Quad City Arts Festival of Trees Holiday Parade on Saturday in Davenport. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people, young and old, lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people, young and old, lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Davenport police take the point and begin the 32nd annual Quad City Arts Festival of Trees Holiday Parade on Saturday in downtown Davenport. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. The Moline Maroons March Band makes its way down Davenport's 3rd Street as part of the 32nd annual Quad City Arts Festival of Trees Holiday Parade on Saturday. The Moline Maroons Marching band high steps it down Davenport's 3rd Street during the 32nd annual Quad City Arts Festival of Trees Holiday Parade held Saturday. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people young and old lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Parade goers young and old found the candy during the 32nd annual Quad City Arts Festival of Trees Holiday Parade held Saturday in Davenport. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people young and old lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Thousands of people lined the streets of downtown Davenport on Saturday for the 32nd annual Quad City Arts Festival of Trees Parade. Get Government & Politics updates in your inbox! Stay up-to-date on the latest in local and national government and political topics with our newsletter. {{description}} Email notifications are only sent once a day, and only if there are new matching items.
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What to know about Scott Turner, Trump's pick for housing secretary