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CAPITAL IDEAS: What was the buzz in 2024?ARTHEx-01 is under clinical development by ARTHEx Biotech and currently in Phase II for Myotonic Dystrophy. According to GlobalData, Phase II drugs for Myotonic Dystrophy does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. ARTHEx-01 overview ARTHEx-01 is under development for the treatment of myotonic dystrophy type 1 (DM1), myotonic dystrophy type 2 (DM2) and congenital DM1. It acts by targeting microRNA 23b (miR-23b) which is associated with regulating the expression of MBNL protein. It is administered through intravenous ARTHEx Biotech overview ARTHEx Biotech, is a spin-off company of the University of Valencia that is developing advanced RNA treatments against genetic diseases. The company is headquartered in Spain. For a complete picture of ARTHEx-01’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
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Bad call! Miserable millennials least likely to call family on Christmas Day but Gen Z WILL pick up the phone - here is why Research by Vodafone UK found half of Brits aged 28 to 43 will text this Christmas READ MORE: Gen Z mocks millennials for the way they purchase big-ticket items By JOWENA RILEY Published: 14:27 GMT, 8 December 2024 | Updated: 14:27 GMT, 8 December 2024 e-mail View comments Miserable millennials are more likely to send a WhatsApp message to their family than speak over the phone this Christmas . According to new research by Vodafone UK, the generation that grew up with Nokia phones is leaning on typing over talking to spread festive cheer this year, with nearly half (49 per cent) of Brits aged 28 to 43 planning to ping loved ones a text. While Millennials might be hitting 'send' rather than dialing, their tech habits set them apart from younger and older generations. Despite texting being the preferred method of communication for Gen Z , they are most likely to opt for a video call to wish loved ones a 'Happy Christmas.' Meanwhile, the Baby Boomer generation, champions of tradition, are sticking to classic phone calls this year. The survey also found that connectivity is central to Christmas in the modern world, with more than half of Brits admit they struggle to imagine the holiday without it. Besides staying in touch, the top ways Brits use phones, tablets and laptops at Christmas include shopping, finding discounts, social media - and tracking when to take their turkey out of the oven. For some, tech plays an even bigger role - over two in five parents say digital tools help make Christmas more magical, from streaming festive music and videos to tracking Santa's sleigh. Miserable millennials are more likely to send a WhatsApp message to their family than speak over the phone this Christmas (stock image) However, Britons most appreciate the opportunity to reconnect and get together with loved ones, with over two thirds valuing hearing from loved ones more than Christmas dinner (47 per cent), presents (23 per cent), or family games (18 per cent). But not everyone is feeling the digital warmth this Christmas, as nearly half of Brits report experiencing loneliness during the holidays, citing reasons like not having loved ones nearby or lacking the skills or means to connect digitally. According to the study, a third of Brits will be spending this Christmas apart from their loved ones, for reasons such as being with a partner's family or working. This includes a quarter (24 per cent) of both Gen Z and Millennials who will be spending their first Christmas away from their parents. Nicki Lyons from Vodafone UK said: 'Connecting with loved ones is a hugely important part of the festive season and if you aren't together in person, technology becomes central to making that connection. 'But for those without access to this, due to a lack of skills or the means to get online, the simple act of having a voice call with a faraway family member or messaging a friend at work is out of reach.' The research comes as Vodafone announced it has helped three million digitally excluded people and businesses cross the digital divide as part of its everyone.connected initiative. Meanwhile, a study has shown young Britons want to ditch turkey from their Christmas dinner along with other much-loved festive traditions. Despite texting being the preferred method of communication for Gen Z , they are most likely to opt for a video call to wish loved ones a 'Happy Christmas' (stock image) Read More My snowflake Gen-Z staff terrified me into quitting. And I'm SO glad I did! Gen Z are keen for a meat-alternative on December 25 and would also rather replace an after dinner cheese board, the research by Costa Coffee has revealed. Despite 68% of Brits stating that their households enjoy the same 'traditional' Christmas meal, the findings show that younger and older generations have very different views about Christmas food, treats and even baubles. It's due to the younger generations changing attitudes on booze, with an increasing number of young people reducing their alcohol intake or adopting teetotal lifestyles. Though revellers will wave goodbye to alcohol, they can expect to enjoy a solid night's sleep in its place. Mistletoe is also a firm no-no because, according to renowned auctioneer Nick 'Mr Mistletoe' Champion, whose mistletoe sales have plummeted in recent years, 'young people aren't interested in kissing under the mistletoe anymore'. Whatsapp Share or comment on this article: Bad call! Miserable millennials least likely to call family on Christmas Day but Gen Z WILL pick up the phone - here is why e-mail Add commentAcross Europe, Syrians hold joyful rallies to celebrate fall of Assad BERLIN: Thousands of jubilant Syrians rallied in Berlin and cities across Europe on Sunday, waving flags and singing with joy to celebrate the fall of President Bashar al-Assad. “Finally we are free!” exclaimed a smiling Bassam Al-Hamada, 39, among 5,000 people at an exuberant rally in the capital of Germany, the country home to the largest Syrian community in Europe. Many waved the flag of the Syrian opposition and signs that read “Free Syria” and “Freedom”. Others flashed the “V” for victory sign, sang and shouted “Allahu Akbar!” Many came with their families, braving a cold drizzle. Children ́s faces were painted in the Syrian national colours at the packed square in Berlin ́s Kreuzberg district, where chants mingled with the honking horns of passing cars. Germany is home to more than a million Syrians, the largest diaspora in the European Union, most of them asylum seekers who fled the civil war raging since 2011. Many live in Berlin ́s working-class district of Neukoelln, where a spontaneous outpouring of relief began early on Sunday -- a day that also saw Syrian community rallies in Athens, London, Vienna and other cities. Hundreds celebrated in joyous scenes outside the Fatih Mosque in central Istanbul, one of the focal points for their 500,000-strong Syrian community in the Turkish city. “We ́re happy. The dictatorship is over. Assad has gone,” said 39-year-old Berlin resident Ahmed, who preferred not to give his last name. “All Syrians are together now,” said the railway technician, who fled the northern Syrian city of Aleppo in 2015. Also joining the happy crowd in Berlin was Ahmad al-Hallabi, 27, a mechanic, also from Aleppo, who fled via Turkey and Greece to Germany in 2015, the peak of the migrant influx to the EU. “Ten years ago, I was in Syria and saw things no-one should have to see, things that are impossible to wipe from your memory,” he said. “Assad is the worst terrorist imaginable ... I hope there ́ll be peace and everything Assad and his men destroyed will be rebuilt.” Many at the rally expressed cautious hope they would soon be able to return to their war-battered home country. “Like many Syrians, I would like to return to my country to help rebuild it,” said Bassam Al-Hamada, a social worker who arrived in Germany in early 2016. His compatriot Sabreen, 36, an architect, said she planned for the moment to “help from Germany”. “They mainly need expertise and money. All of that, we can gather here for the moment,” added the young woman. Like many of the protesters in Berlin, Sabreen called for Assad to be held accountable for killing and torturing his own people. “He must be tried in the international court in The Hague,” she said. Hundreds of ecstatic Syrians celebrated the fall of Assad on London ́s Trafalgar Square, hugging each other and chanting “Mabrouk!” (Congratulations!). Syrians greeted each other, many with the opposition flag draped over their shoulders, and singing: “Syria is ours, not the Assad family ́s”. Several hundred Syrians also rallied outside parliament in central Athens. “Allah, Syria, freedom!” and “together, together, together,” they chanted in a jubilant atmosphere.
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AP News Summary at 1:11 p.m. ESTThe military's tradition of tracking Santa Claus on his gravity-defying sweep across the globe will carry on this Christmas Eve, even if the U.S. government shuts down , officials said Friday. Each year, at least 100,000 kids call into the North American Aerospace Defense Command to inquire about Santa’s location. Millions more follow online — in nine languages — as St. Nick swoops along the earth's meridians. “We fully expect for Santa to take flight on Dec. 24 and NORAD will track him," the U.S.-Canadian agency said in a statement. On any other night, NORAD is scanning the heavens for potential threats , such as last year's Chinese spy balloon . But on Christmas Eve, volunteers in Colorado Springs, Colorado, are fielding questions like, “When is Santa coming to my house?” and, “Am I on the naughty or nice list?” The endeavor is supported by local and corporate sponsors, who also help shield the tradition from Washington dysfunction. Bob Sommers, 63, a civilian contractor and NORAD volunteer, told The Associated Press that there are "screams and giggles and laughter” when families call in, usually on speakerphone. Sommers often says on the call that everyone must be asleep before Santa arrives, prompting parents to say, "Do you hear what he said? We got to go to bed early." NORAD's annual tracking of Santa has endured since the Cold War , predating ugly sweater parties and Mariah Carey classics . Here's how it began and why the phones keep ringing. It started with a child's accidental phone call in 1955. The Colorado Springs newspaper printed a Sears advertisement that encouraged children to call Santa, listing a phone number. A boy called. But he reached the Continental Air Defense Command, now NORAD, a joint U.S. and Canadian effort to spot potential enemy attacks. Tensions were growing with the Soviet Union, along with anxieties about nuclear war. Air Force Col. Harry W. Shoup picked up an emergency-only “red phone” and was greeted by a tiny voice that began to recite a Christmas wish list. “He went on a little bit, and he takes a breath, then says, ‘Hey, you’re not Santa,’” Shoup told The Associated Press in 1999. Realizing an explanation would be lost on the youngster, Shoup summoned a deep, jolly voice and replied, “Ho, ho, ho! Yes, I am Santa Claus. Have you been a good boy?” Shoup said he learned from the boy's mother that Sears mistakenly printed the top-secret number. He hung up, but the phone soon rang again with a young girl reciting her Christmas list. Fifty calls a day followed, he said. In the pre-digital age, the agency used a 60-by-80-foot (18-by-24-meter) plexiglass map of North America to track unidentified objects. A staff member jokingly drew Santa and his sleigh over the North Pole. The tradition was born. “Note to the kiddies,” began an AP story from Colorado Springs on Dec. 23, 1955. “Santa Claus Friday was assured safe passage into the United States by the Continental Air Defense Command.” In a likely reference to the Soviets, the article noted that Santa was guarded against possible attack from "those who do not believe in Christmas.” Some grinchy journalists have nitpicked Shoup's story, questioning whether a misprint or a misdial prompted the boy's call. In 2014, tech news site Gizmodo cited an International News Service story from Dec. 1, 1955, about a child's call to Shoup. Published in the Pasadena Independent, the article said the child reversed two digits in the Sears number. "When a childish voice asked COC commander Col. Harry Shoup, if there was a Santa Claus at the North Pole, he answered much more roughly than he should — considering the season: ‘There may be a guy called Santa Claus at the North Pole, but he’s not the one I worry about coming from that direction,'" Shoup said in the brief piece. In 2015, The Atlantic magazine doubted the flood of calls to the secret line, while noting that Shoup had a flair for public relations. Phone calls aside, Shoup was indeed media savvy. In 1986, he told the Scripps Howard News Service that he recognized an opportunity when a staff member drew Santa on the glass map in 1955. A lieutenant colonel promised to have it erased. But Shoup said, “You leave it right there,” and summoned public affairs. Shoup wanted to boost morale for the troops and public alike. “Why, it made the military look good — like we’re not all a bunch of snobs who don’t care about Santa Claus,” he said. Shoup died in 2009. His children told the StoryCorps podcast in 2014 that it was a misprinted Sears ad that prompted the phone calls. “And later in life he got letters from all over the world,” said Terri Van Keuren, a daughter. "People saying ‘Thank you, Colonel, for having, you know, this sense of humor.’” NORAD's tradition is one of the few modern additions to the centuries-old Santa story that have endured, according to Gerry Bowler, a Canadian historian who spoke to the AP in 2010. Ad campaigns or movies try to “kidnap” Santa for commercial purposes, said Bowler, who wrote “Santa Claus: A Biography.” NORAD, by contrast, takes an essential element of Santa's story and views it through a technological lens. In a recent interview with the AP, Air Force Lt. Gen. Case Cunningham explained that NORAD radars in Alaska and Canada — known as the northern warning system — are the first to detect Santa. He leaves the North Pole and typically heads for the international dateline in the Pacific Ocean. From there he moves west, following the night. “That's when the satellite systems we use to track and identify targets of interest every single day start to kick in,” Cunningham said. “A probably little-known fact is that Rudolph’s nose that glows red emanates a lot of heat. And so those satellites track (Santa) through that heat source.” NORAD has an app and website, www.noradsanta.org , that will track Santa on Christmas Eve from 4 a.m. to midnight, mountain standard time. People can call 1-877-HI-NORAD to ask live operators about Santa’s location from 6 a.m. to midnight, mountain time.
HOUSTON (AP) — Tyler Herro scored 27 points before being one of six people ejected after a fight in the final minute of the Miami Heat’s 104-100 victory over the Houston Rockets on Sunday night. Herro was thrown to the ground by the Rockets’ Amen Thompson with 35 seconds left and the Heat leading 99-94. Players and coaches from both benches then came onto the court. Both players were thrown out along with Rockets guard Jalen Green, coach Ime Udoka and assistant coach Ben Sullivan. Terry Rozier was also ejected for Miami. Houston led 92-85 after Fred VanVleet’s layup with 8:10 to play, but the Rockets missed their next 11 shots, allowing Miami to tie the game when Herro found Haywood Highsmith for a 3-pointer with 4:47 to play. Herro’s jumper with 1:56 to play put the Heat on top for good. MAGIC 102, NETS 101 ORLANDO, Fla. (AP) — Cole Anthony drove for a layup with 0.2 seconds left to complete Orlando's 17-point fourth-quarter comeback in a win over Brooklyn. Cam Thomas missed a jumper from the corner at the final horn. Anthony scored 10, and Tristan da Silva scored 13 of his 21 points in the fourth quarter for Orlando, which was down 71-51 midway through the third quarter. Goga Bitadze added 19 points, 11 rebounds and five assists. The Magic’s comeback was their second in eight days after Orlando rallied from 25 points down to beat Miami 121-114 on Dec. 21. Thomas came off the bench with 25 points to lead the Nets in his first game since Nov. 25. Jalen Wilson added 16 points including two free throws with 6.2 seconds left. Thomas, Brooklyn’s leading scorer with 24.7 points per game, played 25 minutes after missing 13 games with a strained left hamstring. PACERS 123, CELTICS 114 BOSTON (AP) — Tyrese Haliburton scored 31 points and Indiana rebounded from a 37-point loss to Boston two nights earlier by winning the rematch. Andrew Nembhard, who returned after missing Friday’s game with tendinitis in his left knee, added 17 points, eight rebounds and eight assists for the Pacers. Pascal Siakam chipped in with 17 points and Bennedict Mathurin had 14. Jaylen Brown led Boston with 31 points and six assists. Jayson Tatum had 22 points, nine boards and six assists. Payton Pritchard added 21 points and Derrick White scored 17. The Celtics lost their sixth game at home already this season. Last season, they went 37-4 at TD Garden during the regular season and 9-2 in the playoffs en route to the NBA championship. HAWKS 136, RAPTORS 107 TORONTO (AP) — Trae Young had 34 points and 10 assists, De’Andre Hunter scored 22 points and Atlanta routed Toronto for their fourth straight win. Clint Capela had 11 points and 13 rebounds as the Hawks opened a six-game trip by handing the reeling Raptors their 10th consecutive loss. Scottie Barnes scored 19 points and RJ Barrett had 17, but the Raptors fell behind by more than 30 points and allowed more than 130 for the second straight game. Toronto gave up a franchise-worst 155 points in Thursday’s loss at Memphis. Young shot 7 for 13 from 3-point range, singlehandedly making as many shots from distance than the entire Raptors team, who combined to go 7 for 24. Toronto’s Bruce Brown made his season debut after sitting out the first 31 games recovering from right knee surgery. Brown soared for a one-handed dunk for his first points shortly after entering the game in the first quarter. He finished with 12 points in 19 minutes. THUNDER 130, GRIZZLIES 106 OKLAHOMA CITY (AP) — Shai Gilgeous-Alexander scored 35 points and Oklahoma City won their 11th straight game, beating short-handed Memphis in a matchup of Western Conference leaders that turned lopsided before halftime. Rookie Ajay Mitchell scored 17 points, Aaron Wiggins contributed 16 and Jalen Williams added 14 points and 10 rebounds for the Thunder (26-5), who opened a five-game lead over second-place Memphis. Gilgeous-Alexander made 14 of 19 shots to go along with seven assists, six rebounds and a team-high four blocks. He sat most of the fourth quarter. Oklahoma City blocked nine shots, including three by center Isaiah Hartenstein. The Thunder led 76-50 at halftime behind 23 points from Gilgeous-Alexander and 12 each from Mitchell and Kenrich Williams, who combined to go 5 for 7 on 3-point shots. Oklahoma City outscored the Grizzlies 42-19 in the second quarter to take control. Desmond Bane had 22 points and nine rebounds for Memphis (22-11), which played without star Ja Morant (shoulder) and Zach Edey, the team’s No. 9 overall draft pick, who was in concussion protocol. Jay Huff added 17 points but Jaren Jackson Jr., the team’s leading scorer at 21.9 points per game, managed 13 points on 3-of-17 shooting.