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Researchers have found a way to program immune cells to attack glioblastoma and treat the inflammation of multiple sclerosis in mice. The technology will soon be tested in a clinical trial for people with glioblastoma. UCSF scientists have developed a "molecular GPS" to guide immune cells into the brain and kill tumors without harming healthy tissue. This living cell therapy can navigate through the body to a specific organ, addressing what has been a major limitation of CAR-T cancer therapies until now. The technology worked in mice and the researchers expect it to be tested in a clinical trial next year. The scientists showed how the immune cells could eliminate a deadly brain tumor called glioblastoma and prevent recurrences. They also used the cells to tamp down inflammation in a mouse model of multiple sclerosis. "Living cells, especially immune cells, are adapted to move around the body, sense where they are, and find their targets," said Wendell Lim, PhD, UCSF professor of cellular and molecular pharmacology and co-senior author of the paper, which appears in Science on Dec. 5. Navigating to the source of disease Nearly 300,000 patients are diagnosed with brain cancers each year in the United States, and it is the leading cause of cancer mortality in children. Brain cancers are among the hardest cancers to treat. Surgery and chemotherapy are risky, and drugs can't always get into the brain. To get around these problems, the scientists developed a "molecular GPS" for immune cells that guided them with a "zip code" for the brain and a "street address" for the tumor. They found the ideal molecular zip code in a protein called brevican, which helps to form the jelly-like structure of the brain, and only appears there. For the street address, they used two proteins that are found on most brain cancers. The scientists programmed the immune cells to attack only if they first detected brevican and then detected one or the other of the brain cancer proteins. Related Stories Brain scan could predict success of spinal surgery for chronic pain Frontotemporal dementia disrupts empathy for pain, study reveals Spider brain studies lead to breakthrough in understanding human brain diseases Once in the bloodstream, they easily navigated to the mouse's brain and eliminated a growing tumor. Immune cells that remained in the bloodstream stayed dormant. This prevented tissues elsewhere in the body that happened to have the same protein "address" from being attacked. One hundred days later, the scientists introduced new tumor cells into the brain, and enough immune cells were left to find and kill them, a good indication that they may be able to prevent any remaining cancer cells from growing back. The brain-primed CAR- T cells were very, very effective at clearing glioblastoma in our mouse models, the most effective intervention we've seen yet in the lab. It shows just how well the GPS ensured that they would only work in the brain. The same strategy even worked to clear brain metastases of breast cancer." Milos Simic, PhD, the Valhalla Foundation Cell Design Fellow and co-first author of the paper In another experiment, the researchers used the brain GPS system to engineer cells that deliver anti-inflammatory molecules to the brain in a mouse model of multiple sclerosis. The engineered cells reached their target, and the inflammation faded. The scientists hope this approach will soon be ready for patients with other debilitating nervous system diseases. "Glioblastoma is one of the deadliest cancers, and this approach is poised to give patients a fighting chance," said Hideho Okada, MD, UCSF oncologist and co-senior author of the paper. "Between cancer, brain metastases, immune disease and neurodegeneration, millions of patients could someday benefit from targeted brain therapies like the one we've developed." University of California San Francisco Simic, M. S., et al . (2024) Programming tissue-sensing T cells that deliver therapies to the brain. Science . doi.org/10.1126/science.adl4237 .Reeling Cowboys visit Dan Quinn's overachieving Commanders in a franchise role reversalMusk's millions for Trump make him biggest US political donorLindsey Vonn to enter World Cup ski races next weekend in Switzerland in her comeback at age 40 BEAVER CREEK, Colo. (AP) — Lindsey Vonn will return to World Cup ski racing next weekend for a pair of super-G events in St. Moritz, Switzerland, as she continues her comeback at 40 years old. Vonn teased her return in an Instagram post through her sponsor, Red Bull, on Friday morning. She said “I hear St. Moritz is pretty nice this time of year.” The U.S. Ski Team then confirmed she will race in St. Moritz. She’s won five of her 82 World Cup races on the venue at St. Moritz. Picabo Street, a two-time Olympic medalist and Vonn’s former teammate, says “it’s the coolest thing ever.” De'Vondre Campbell won't be part of the 49ers after his refusal to enter a game, Kyle Shanahan says SANTA CLARA, Calif. (AP) — San Francisco coach Kyle Shanahan said linebacker De’Vondre Campbell won’t be part of the 49ers moving forward after he refused to enter a game after losing his starting job. Shanahan said the team is still working through the options of how to deal with Campbell after he walked to the locker room in the middle of a 12-6 loss to the Los Angeles Rams. Shanahan says the team is weighing its options, which could include a suspension or release, but that Campbell won't be part of the team for the final three weeks of the season. Saudi Arabia's plans to host the men's World Cup 2034 will be harmful for the climate, experts say Saudi Arabia says that to host the 2034 World Cup in men’s soccer, it will build or renovate 15 stadiums, create a futuristic city and expand airports and public transport in a massive buildout to accommodate millions of athletes, coaches and spectators. That will emit tons of planet-warming greenhouse gases as concrete and steel are manufactured and transported, diesel-powered excavators and trucks move material and new buildings are powered and cooled. The buildings and construction sector, taken together, is the largest emitter of greenhouse gases globally. Because of the scale of the building plans and travel needed for the event, experts say the toll on the climate could be enormous. Yankees get closer Devin Williams from Brewers for Nestor Cortes, Caleb Durbin NEW YORK (AP) — The New York Yankees acquired All-Star closer Devin Williams from the Milwaukee Brewers for left-hander Nestor Cortes and infield prospect Caleb Durbin. The Yankees also will send $2 million to the Brewers as part of the trade. A 30-year-old right-hander, Williams and his signature “Airbender” changeup are eligible for free agency after the 2025 season. He was diagnosed during spring training with two stress fractures in his back and didn’t make his season debut until July 28. Williams was 14 for 15 in save chances with a 1.25 ERA, striking out 38 and walking 11 in 21 2/3 innings. Cubs acquiring All-Star outfielder Kyle Tucker in trade with the Astros, AP source says CHICAGO (AP) — The Chicago Cubs are acquiring All-Star outfielder Kyle Tucker in a trade with the Houston Astros, paying a big price for one of baseball’s best hitters, a person familiar with the situation said. The person spoke to the AP on condition of anonymity because the move was pending a review of medical reports. The Cubs are sending third baseman Isaac Paredes, right-hander Hayden Wesneski and Cam Smith, one of their top infield prospects, to the Astros for Tucker, who is eligible for free agency after the 2025 season. Tucker was limited to 78 games this year because of a fractured right shin, but he hit .289 with 23 homers and 49 RBIs for the AL West champions. US Olympic and Paralympic officials put coach on leave after AP reports sexual abuse allegations The U.S. Olympic & Paralympic Committee has placed an employee on administrative leave after The Associated Press reported that one of its coaches was accused of sexually abusing a young biathlete, causing her so much distress that she attempted suicide. USOPC officials sent an email to the U.S. Biathlon national team saying it wanted to commend the athletes who came forward with the “concerning allegations of abuse." The email, which did not name the employee, said officials were conducting an internal investigation. USOPC spokesperson Jon Mason said no further information would be released while the inquiry is underway. Woman who falsely accused Duke lacrosse players of rape in 2006 publicly admits she lied RALEIGH, N.C. (AP) — The woman who in 2006 falsely accused three Duke University lacrosse players of raping her has admitted publicly for the first time that she made up the story. The accusations made national headlines at the time, stirring tensions about race, class and the privilege of college athletes. Crystal Mangum, who is Black, said in an interview with the “Let’s Talk with Kat” podcast that she “made up a story that wasn’t true” about the white players who attended a party where she was hired to perform as a stripper “because I wanted validation from people and not from God.” The former Duke players were declared innocent in 2007 after Mangum’s story fell apart under legal scrutiny. Analysis: Only LeBron James knows what's happening right now, and what's in his future LAS VEGAS (AP) — LeBron James was starring in Las Vegas at this time last year, the headline attraction while he and the Los Angeles Lakers were about to win the inaugural version of the event now known as the NBA Cup. That's not the case this year. “Personal reasons ... he’s taking some time” is what Lakers coach JJ Redick said this week when detailing why James was missing from practice. “Left foot soreness” is the reason why the Lakers have ruled him out of Friday’s game in Minnesota. There’s been trade speculation in recent days. It's all very different than a year ago at Cup time. Does the NBA Cup need star power or does Las Vegas sell itself? LAS VEGAS (AP) — The NBA In-Season Tournament semifinals and final debuted last season in Las Vegas. The championship game between the Los Angeles Lakers and Indiana Pacers sold out. The renamed NBA Cup is back beginning Saturday. The question is whether star power will help sell the event on a neutral site or if Las Vegas is enough of a sell itself. Former two-time NBA MVP Giannis Antetokounmpo and this season’s second-best bet in Shai Gilgeous-Alexander will be the featured names. Belichick's bid to reshape football at UNC another sign of rising pro influence on college level CHAPEL HILL, N.C. (AP) — North Carolina's hiring of NFL coaching great Bill Belichick marks another sign of the growing influence of the NFL on college football. The challenges of managing the transfer portal and looming revenue sharing for athletes has led teams to take on more NFL-like structures to their programs. Belichick is set to structure North Carolina's program like an NFL front office. That includes hiring former NFL executive Michael Lombardi as general manager. At Florida, coach Billy Napier is interviewing general managers while saying the program is going to “a business model” to deal with a “major math puzzle.”
Rachel Christian | (TNS) Bankrate.com Just because retirement planning involves some guesswork doesn’t mean it has to be a total mystery. Related Articles Business | Nearly half of US teens are online ‘constantly,’ Pew report finds Business | How to protect your communications through encryption Business | About 2.6 million Stanley cups recalled after malfunctions caused burns. Is your mug included? Business | Musk says US is demanding he pay penalty over disclosures of his Twitter stock purchases Business | Bank groups sue the Consumer Financial Protection Bureau over a proposed cap on overdraft fees Whether you’ve been saving since your first job or you’re getting a late start, you can leverage expert-recommended strategies to gauge your progress on the road to retirement. And if you’re not quite on track, don’t sweat it — the experts we spoke to offered actionable tips to help you close the gap. 5 ways to tell if you’re on track for retirement You might have a general idea of how much money you need to save for retirement . A few quick calculations can give you an estimate, but to truly appreciate where you stand, you’ll need to dive into the numbers. Here’s how to get started. 1. Use the Rule of 25 to get a ballpark number A good rule of thumb to estimate your retirement savings goal is the Rule of 25 . Simply multiply your desired annual retirement income by 25. The result is roughly how much you’ll need to save before hitting retirement. For example, if you plan to spend $50,000 a year, you’ll need about $1.25 million to make it a reality. The Rule of 25 is based on the idea that withdrawing 4% annually from your retirement savings should last you about 30 years. While it’s not an exact science by any means — health care costs and lifestyle changes can skew the numbers, for example — the Rule of 25 can be a good starting point to figure out how much you need to save. 2. Compare your savings to Fidelity guidelines Fidelity Investments, a behemoth in the retirement planning space, offers savings guidelines to help you determine if you’re on track . —By age 30: Save 1x your annual salary —By age 40: Save 3x your annual salary —By age 50: Save 6x your annual salary —By age 60: Save 8x your annual salary —By age 67: Save 10x your annual salary For example, if you earn $60,000 annually, you should aim for $600,000 in savings by age 67. But like the Rule of 25, Fidelity’s guidelines offer a 10,000-foot look at retirement goals, and they’re not customized to your situation. Maybe you earned a low salary in your 20s, but you’re working hard in your 30s to make up for it. Use these estimates as a benchmark — but don’t get discouraged if you’re lagging behind. 3. Use an online retirement calculator Now it’s time to zoom in a little. To get a clearer snapshot of your progress, use an online retirement calculator. These tools factor in your age, current savings, income and lifestyle goals to estimate whether you’re on track. You’ll get a more refined estimate without crunching the numbers yourself. Bankrate’s retirement calculator even lets you input different rates of return on your investments and accounts for estimated annual salary increases. 4. Map out your retirement budget Having a general savings goal is nice, but to avoid falling short in retirement, you’ll need more than a ballpark figure. Experts recommend creating a retirement budget to get an up-close-and-personal look at how much you’ll really need once you leave the workforce. First, estimate how much you’ll spend per month in retirement. While some costs will increase, like health care, others will likely decrease, like dining out and commuting. “Estimating expenses can be challenging for some people, so as a starting point, I often use your net take-home pay,” says Jeff DeLarme, a certified financial planner and president of DeLarme Wealth Management. For example, if you receive a direct deposit of $2,500 every two weeks from work, use $5,000 as your estimated monthly spending in retirement. “Assuming this was enough to pay the bills while working, we can use $5,000 a month as a starting budget to plan for,” says DeLarme. Next, map out your sources of income in retirement. Social Security is the largest income stream for most retirees, but don’t neglect other inflows, such as: —Workplace retirement accounts, like 401(k)s —Personal retirement accounts, like a traditional or Roth IRA —Pensions —Annuities —Selling your home or business —Rental income —Inheritance “If there’s a gap between your expected expenses and income, you’ll have a good idea of how much you need to save,” says Mike Hunsberger, a certified financial planner and owner of Next Mission Financial Planning. From there, you can adjust your savings and investment strategy accordingly. 5. Talk to a financial adviser For something as important (and complex) as retirement planning, it pays to speak with a professional. Financial advisers can analyze your savings, investments and retirement goals to create a personalized plan. Advisers use special planning software that account for more variables than an online calculator, giving you a much more precise, granular look at your financial life in retirement. Many financial advisers can also help you optimize your tax strategy, which can potentially save you thousands of dollars over time. Make sure the adviser you hire is a fiduciary , meaning they’re legally obligated to prioritize your interests over their own. A fiduciary won’t push investments to earn a commission or recommend products that aren’t aligned with your needs. A certified financial planner is one of the most well-recognized designations for fiduciaries. You can use Bankrate’s adviser matching tool to find a certified financial planner in your area in minutes. 5 ways to catch up on retirement savings Maybe you did the math and realized you’re not quite where you need to be. Don’t panic if you’re behind schedule. Here are five strategies experts recommend to help you catch up on your retirement savings . 1. Scale back your spending now and in retirement Cutting expenses now frees up more cash to invest in your retirement accounts. Evaluate your budget and identify areas where you can cut costs, like dining out, streaming subscriptions or shopping. Don’t rule out bigger lifestyle changes either, especially if retirement is rapidly approaching. Housing is the biggest monthly expense for most people. Getting creative here can help amplify the amount you can sock away, says Joseph Boughan, a certified financial planner and managing member at Parkmount Financial Partners. It can also reduce your expenses in retirement, so you may not need to save as much as before. “Downsizing can be a great way to cut expenses,” says Boughan. “This can even free up cash if you don’t end up needing all that money for a new home.” Moving somewhere with lower property taxes or income taxes can also help bring your retirement plan back in line. And if you’re a renter, making tough short-term decisions, like taking on a roommate or moving to a lower cost-of-living area, can free up hundreds of dollars a month for your retirement. “Everyone’s plan is unique, so exploring all the options is important,” Boughan says. Joe Conroy, a certified financial planner and owner of Harford Retirement Planners, recommends taking a “retirement test drive” as you near your target date. “Start to live on what income you think you can afford in retirement and stash all the extra income into savings and investments,” says Conroy. “If you can make it through each month, you’re ready for retirement. If you run short, then adjust your plan accordingly.” 2. Delay retirement by a year or two Working a little longer can be a game-changer for your retirement nest egg. Not only does it give you more time to save, it also gives your investments room to grow. “Working longer or even just part time for a few years early in retirement is one of the best ways to reduce the amount of money you need to save,” says Hunsberger. Postponing retirement can also boost your Social Security benefits . “You can claim as early as 62, but your benefits will be reduced significantly,” says Hunsberger. Meanwhile, each year you delay claiming Social Security benefits beyond your full retirement age , your monthly check will increase by 8%, though this benefit maxes out at age 70. So waiting can really pay off. 3. Save more It may seem obvious, but if you’re behind on retirement savings, you’ll need to boost your contributions as much as possible. Here are a few ways to make saving for retirement easier: —Increase your contribution rate: Allocate a larger portion of your paycheck to a workplace retirement plan. Even bumping up your contributions by 1% or 2% can make a huge difference down the road. —Take advantage of your employer match: Don’t leave free money on the table. Many employers will chip in between 3 and 5% depending on your plan, so make sure you’re contributing enough to take advantage of the benefit. —Use “unexpected” money to catch up: If you get a raise or bonus at work, funnel part of it directly into your 401(k). And if you get a refund at tax time, siphon some of it off to beef up your IRA. 4. Invest more aggressively If you’ve been investing in low-risk, low-return investments, you may not be keeping up with inflation, let alone growing your nest egg. Reallocating part of your portfolio to stocks or low-cost growth exchange-traded funds (ETFs) is one way to get your money working harder. Higher-risk investments like stocks carry more volatility but also offer higher potential returns. Work with a financial adviser or use a robo-adviser to strike the right balance between growth and your personal risk tolerance. 5. Take advantage of new retirement account catch-up contributions Contribution limits for 401(k) plans and IRAs are higher for people over 50. For 2025, employees aged 50 and up who participate in most 401(k) plans or the federal government’s Thrift Savings Plan can save up to $31,000 annually, including a $7,500 catch-up contribution . But thanks to SECURE 2.0 , a sweeping retirement law, a new higher catch-up contribution limit of $11,250 applies for employees ages 60 to 63. So, if you’re in this age group, you can squirrel away a whopping $34,750 a year during the final stretch of your career. Of course, you’ll need a big salary (think six figures) in order to take full advantage of such massive contribution limits. But if you can afford it, these catch-up allowances can put your plan back on track, especially if you struggled to save much early in your career. Bottom line There’s no GPS to gauge your progress on the road to retirement. If you’ve veered off course or aren’t sure where to start, begin by getting a quick estimate of how much you’ll need before mapping out a retirement budget. And if you’re behind, don’t panic — adjusting your spending, boosting your contributions and speaking with a financial adviser can help you catch up. ©2024 Bankrate.com. Distributed by Tribune Content Agency, LLC.
Thomas Jefferson girls fall to PurdyShare this Story : Impaired driving arrests up in week two of RIDE program, OPP East Region reports Copy Link Email X Reddit Pinterest LinkedIn Tumblr Breadcrumb Trail Links News Local News Impaired driving arrests up in week two of RIDE program, OPP East Region reports Officers in the region have conducted more than 380 Festive RIDE programs since this year's efforts began on Nov. 21. Author of the article: Staff Reporter Published Dec 06, 2024 • Last updated 21 minutes ago • 1 minute read Join the conversation You can save this article by registering for free here . Or sign-in if you have an account. An OPP officer speaks with a driver during a Festive RIDE spot check near Simcoe, Ont., in late November. Photo by Brian Thompson / POSTMEDIA Article content Ontario Provincial Police officers across the East Region have charged a total of 45 motorists with impaired driving since the Festive RIDE (Reduce Impaired Driving Everywhere) initiative began two weeks ago, the force said Friday. Article content Article content The previous week’s total was 23. “We know people are getting into the holiday spirit, but impaired driving can instantly change a celebration to a tragedy. It’s a simple message: If you drink or consume drugs, don’t get behind the wheel,” Chief Supt. Lisa Wilhelm, OPP East Region Commander, said in a news release. Advertisement 2 Story continues below This advertisement has not loaded yet, but your article continues below. THIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLY Subscribe now to read the latest news in your city and across Canada. Exclusive articles from Elizabeth Payne, David Pugliese, Andrew Duffy, Bruce Deachman and others. 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Activate your Online Access Now Article content Officers in the region have conducted more than 380 Festive RIDE programs since Nov. 21, stopping nearly 1,000 vehicles to assess whether the drivers were impaired by alcohol or drugs. Besides the 45 impaired driving arrests, officers issued 14 warnings, the release added, meaning those drivers were issued licence suspensions and had their vehicles impounded. RIDE programs can happen anywhere anytime — day or night — the OPP said. Our website is your destination for up-to-the-minute news, so make sure to bookmark our homepage and sign up for our newsletters so we can keep you informed. Recommended from Editorial Ottawa man and woman face drug charges after south-end traffic stop Ottawa's Trillium Line LRT to open Jan. 6 Article content Share this article in your social network Share this Story : Impaired driving arrests up in week two of RIDE program, OPP East Region reports Copy Link Email X Reddit Pinterest LinkedIn Tumblr Comments You must be logged in to join the discussion or read more comments. Create an Account Sign in Join the Conversation Postmedia is committed to maintaining a lively but civil forum for discussion. Please keep comments relevant and respectful. Comments may take up to an hour to appear on the site. You will receive an email if there is a reply to your comment, an update to a thread you follow or if a user you follow comments. Visit our Community Guidelines for more information. Trending Brady Tkachuk to New York Rangers rumour is 'Total bulls--t' and 'garbage' Ottawa Senators Pure Kitchen shuts doors on Rideau Street location Local Business Ottawa's Trillium Line LRT to open Jan. 6 Local News Ottawa man and woman face drug charges after south-end traffic stop News Former Ottawa Senators star Dany Heatley says criticism hurt, turns jeers to cheers in return Ottawa Senators Read Next Latest National Stories Featured Local SavingsFACT FOCUS: Inspector general’s Jan. 6 report misrepresented as proof of FBI setup
According to UFC President Dana White, No. 2-ranked Umar Nurmagomedov is next in line for a title shot against reigning bantamweight champion Merab Dvalishvili. However, Nurmagomedov might have irritated White and the rest of the UFC brass with an image he posted on his social media on Sunday. Nurmagomedov has been embroiled in a feud with Dvalishvili on social media. Dvalishvili’s perceived hesitation to face Nurmagomedov in his first title defense—after winning the belt in September in the main event of Noche UFC —is at the root of the conflict. Dvalishvili took to social media on Saturday morning to praise No. 3-ranked Petr Yan’s win over Deiveson Figueiredo. Yan challenged Dvalishvili to a rematch, as the champion defeated him in March 2023, and Dvalishvili accepted. This sparked a tirade on social media from Nurmagomedov. Some suspect that Nurmagomedov’s manager, Ali Abdelaziz, runs his social media account, but a short video featuring Nurmagomedov was posted to refute those suspicions. Amid the string of posts, Nurmagomedov shared an image of himself working out alongside his cousin and former lightweight champion, Khabib Nurmagomedov. In the image, Umar is wearing a PFL T-shirt. The PFL (Professional Fighters League) is a rival mixed martial arts organization that currently has Umar’s cousin, Usman Nurmagomedov, under contract. Usman is the Bellator welterweight champion, a title now owned by the PFL. It’s entirely possible Umar was simply wearing a random T-shirt available to him—especially if Usman was in the gym and, as family, they share clothing. However, the peculiar aspect is that someone chose to post an image of a high-profile UFC fighter wearing a PFL T-shirt. White has criticized the PFL throughout the year, focusing on its acquisition of Bellator and other business decisions. The biggest sticking point for White has been related to former UFC heavyweight champion and reigning PFL Super Fights champion Francis Ngannou. Ngannou left the UFC as its heavyweight champion and signed with the PFL. After scoring a KO win over Renan Ferreira in his only MMA bout since leaving the UFC, many still consider Ngannou the lineal heavyweight champion of the world. Ngannou’s departure represents perhaps the only significant loss the UFC has suffered in fighter acquisition and retention. Beyond the natural competition between the two promotions, Ngannou’s situation has added to the tension. That tension makes it unusual to see a UFC fighter posting an image of themselves wearing a PFL T-shirt. We’ll see if Nurmagomedov holds his position as the next challenger for Dvalishvili. Nurmagomedov will not fight during Ramadan (Feb. 28–March 25), and Dvalishvili seems to want to fight in March. If Nurmagomedov doesn’t get the first shot, it won’t be because of the T-shirt; it’ll be because Dvalishvili is ready to defend and doesn’t want to wait for the challenger.Republicans Rally Around Hegseth, Trump's Pentagon Pick, as Gaetz Withdraws for Attorney General
India, ISA ink agreement for solar projects in four Indo-Pacific countries