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zombie jollibee Authorities in Pakistan launch operation to clear Khan supporters from capitalCOPENHAGEN, Denmark--(BUSINESS WIRE)--Dec 8, 2024-- Genmab A/S (Nasdaq: GMAB): Preliminary analyses from the EPCORE ® CLL-1 trial demonstrates overall response rate (ORR) of 61 percent and complete response (CR) rate of 39 percent in heavily pretreated patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) who received epcoritamab monotherapy In the study, 75 percent of evaluable responders achieved undetectable minimal residual disease (MRD), indicating no detectable disease following treatment with epcoritamab The data were selected as part of the 2024 American Society of Hematology’s (ASH’s) Annual Meeting Press Program in the Diagnosing and Treating Blood Cancers and “Almost Cancers” briefing Genmab A/S (Nasdaq: GMAB) today announced results from the Phase 1b/2 EPCORE ® CLL-1 clinical trial evaluating epcoritamab (Abstract #883), a T-cell engaging bispecific antibody administered subcutaneously, demonstrated an overall response rate (ORR) of 61 percent and a complete response (CR) rate of 39 percent in difficult-to-treat adult patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) treated with epcoritamab monotherapy. These results, from the monotherapy expansion (EXP) cohort (n=23) of the trial, along with the first safety data from the optimization (OPT) cohort, were presented at the 66 th Annual Meeting and Exposition of the American Society of Hematology (ASH), during the ASH Annual Meeting Press Program. The data will be presented during an oral session on December 9, 2024. In the EXP cohort, the median time to response was two (2.0) months and the median time to CR was 5.6 months. Among all patients in the cohort, median progression-free survival (PFS) was 12.8 months and median overall survival (OS) was not reached (median follow-up was 22.8 months). An estimated 65 percent of patients were alive at 15 months. Among 12 responders evaluable for minimal residual disease (MRD) by next-generation sequencing in peripheral blood, nine patients (75 percent) had undetectable MRD. The most frequent non-hematologic treatment-emergent adverse events (TEAEs) in the EXP cohort were cytokine release syndrome (CRS; 96 percent), diarrhea (48 percent), peripheral edema (48 percent), fatigue (43 percent), and injection-site reaction (43 percent). Cytopenias were common (anemia, 65 percent; thrombocytopenia, 65 percent; neutropenia, 48 percent); however, most patients had baseline anemia and thrombocytopenia, suggesting that these events were largely disease-related. Three cases of immune effector cell-associated neurotoxicity syndrome (ICANS) were reported (one Grade 1; two Grade 2), and there was one clinical tumor lysis syndrome (CTLS) case (Grade 2). These cases did not lead to treatment discontinuation. Four fatal TEAEs occurred - two cases of pneumonia, one case of sepsis and one case of squamous cell carcinoma of the skin. The EXP cohort followed a 2-step step-up dose regimen, and CRS was manageable and primarily low grade (9 percent Grade 1, 70 percent Grade 2, 17 percent Grade 3). In the first data from the separate OPT cohort, which followed a 3-step step-up dose regimen, CRS severity was substantially reduced with only low-grade events (71 percent Grade 1, 12 percent Grade 2). In both cohorts, CRS events primarily occurred following the first full dose, and none led to treatment discontinuation. No ICANS or CTLS cases were reported in the OPT cohort. “These EPCORE CLL-1 data are encouraging, especially as the majority of patients were heavily pre-treated with at least four lines of therapy,” said Alexey Danilov, MD, PhD, Marianne and Gerhard Pinkus, Professor and Director of Early Clinical Therapeutics and Associate Director of the Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope. “Despite progress in treating chronic lymphocytic leukemia, there remains a tremendous need for additional therapeutic options for high-risk patients whose disease has progressed following standard chemoimmunotherapy and targeted therapies.” Additional data from the EXP cohort showed high response rates in patients with high-risk factors treated with epcoritamab, including TP53 aberrations, IGHV-unmutated disease and double-exposed disease – prognostic markers that are associated with disease progression and decreased survival. i,ii,iii In patients with TP53 aberrations (n=15), the ORR was 67 percent with a CR of 33 percent. Among patients with IGHV-unmutated disease (n=16), the ORR was 63 percent, and the CR was 44 percent. In double-refractory patients, the ORR was 53 percent, and the CR was 37 percent. All patients in the trial had prior chemoimmunotherapy, and most patients had previously received targeted therapies such as BTK and BCL2 inhibitors (double-exposed) and had high-risk disease characteristics. “Chronic lymphocytic leukemia is incurable, and patients often need a variety of treatments throughout their lifetime, especially if their disease has high-risk prognostic factors, has relapsed or has become refractory to the current standard-of-care, including targeted therapies,” said Dr. Judith Klimovsky, Executive Vice President & Chief Development Officer, Genmab. “These early data show the potential therapeutic applicability of epcoritamab in relapsed or refractory chronic lymphocytic leukemia, and further reinforce the potential of epcoritamab as a core therapy for the treatment of B-cell malignancies.” Use of epcoritamab in CLL is not approved in the U.S. or in the EU or in any other territory. The safety and efficacy of epcoritamab for use in CLL have not been established. About Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia, affecting over 200,000 people in the United States alone. iv Chronic lymphocytic leukemia can be classified as either slow growing (indolent) or fast growing (aggressive). v CLL is incurable, and many patients will likely relapse and progress on frontline therapies. vi Most patients will experience consecutive episodes of disease progression and will require several lines of treatment in their lifetime. vii,viii About the EPCORE ® CLL-1 Trial EPCORE ® CLL-1 is a Phase 1b/2, open-label, multi-center trial to evaluate the safety and preliminary efficacy of epcoritamab as a monotherapy and in combination with standard of care agents in patients with difficult-to-treat relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), R/R small lymphocytic lymphoma (SLL) and Richter's Syndrome (RS). The trial consists of two parts: a dose-escalation phase (Phase 1b) and an expansion phase (Phase 2). Patients with RS are only included in the expansion phase. The primary objective of Phase 1b is to determine the recommended Phase 2 dose and the maximum tolerated dose as well as establish the safety profile of epcoritamab monotherapy and epcoritamab plus venetoclax in participants with R/R CLL. The purpose of Phase 2 is to assess and evaluate the preliminary efficacy, safety and tolerability profiles of epcoritamab monotherapy and epcoritamab plus venetoclax for patients with R/R CLL and SLL. Additionally, epcoritamab monotherapy and combination therapy will be evaluated in patients with RS to assess their efficacy, safety and tolerability profiles. More information on this trial can be found at https://www.clinicaltrials.gov/ (NCT: 04623541). About Epcoritamab Epcoritamab is an IgG1-bispecific antibody created using Genmab's proprietary DuoBody ® technology and administered subcutaneously. Genmab's DuoBody-CD3 technology is designed to direct cytotoxic T cells selectively to elicit an immune response toward target cell types. Epcoritamab is designed to simultaneously bind to CD3 on T cells and CD20 on B cells and induces T-cell-mediated killing of CD20+ cells. ix Epcoritamab (approved under the brand name EPKINLY ® in the U.S. and Japan, and TEPKINLY ® in the EU) has received regulatory approval in certain lymphoma indications in several territories. Epcoritamab is being co-developed by Genmab and AbbVie as part of the companies' oncology collaboration. The companies will share commercial responsibilities in the U.S. and Japan, with AbbVie responsible for further global commercialization. Both companies will pursue additional international regulatory approvals for the investigational R/R FL indication and additional approvals for the R/R DLBCL indication. Genmab and AbbVie continue to evaluate the use of epcoritamab as a monotherapy, and in combination, across lines of therapy in a range of hematologic malignancies. This includes five ongoing Phase 3, open-label, randomized trials including a trial evaluating epcoritamab as a monotherapy in patients with R/R DLBCL compared to investigator's choice chemotherapy ( NCT04628494 ), a trial evaluating epcoritamab in combination with R-CHOP in adult patients with newly diagnosed DLBCL ( NCT05578976 ), a trial evaluating epcoritamab in combination with rituximab and lenalidomide (R 2 ) in patients with R/R FL ( NCT05409066 ), a trial evaluating epcoritamab in combination with rituximab and lenalidomide (R 2 ) compared to chemoimmunotherapy in patients with previously untreated FL ( NCT06191744 ), and a trial evaluating epcoritamab in combination with lenalidomide compared to chemotherapy infusion in patients with R/R DLBCL ( NCT06508658 ). The safety and efficacy of epcoritamab has not been established for these investigational uses. Please visit www.clinicaltrials.gov for more information. EPKINLY ® (epcoritamab-bysp) U.S. INDICATIONS & IMPORTANT SAFETY INFORMATION What is EPKINLY? EPKINLY is a prescription medicine used to treat adults with certain types of diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, or follicular lymphoma (FL) that has come back or that did not respond to previous treatment after receiving 2 or more treatments. EPKINLY is approved based on patient response data. Studies are ongoing to confirm the clinical benefit of EPKINLY. It is not known if EPKINLY is safe and effective in children. Important Warnings—EPKINLY can cause serious side effects, including: Cytokine release syndrome (CRS), which is common during treatment with EPKINLY and can be serious or life-threatening. To help reduce your risk of CRS, you will receive EPKINLY on a step-up dosing schedule (when you receive 2 or 3 smaller step-up doses of EPKINLY before your first full dose during your first cycle of treatment), and you may also receive other medicines before and for 3 days after receiving EPKINLY. If your dose of EPKINLY is delayed for any reason, you may need to repeat the step-up dosing schedule. Neurologic problems that can be life-threatening and lead to death. Neurologic problems may happen days or weeks after you receive EPKINLY. People with DLBCL or high-grade B-cell lymphoma should be hospitalized for 24 hours after receiving their first full dose of EPKINLY on day 15 of cycle 1 due to the risk of CRS and neurologic problems. Tell your healthcare provider or get medical help right away if you develop a fever of 100.4°F (38°C) or higher; dizziness or lightheadedness; trouble breathing; chills; fast heartbeat; feeling anxious; headache; confusion; shaking (tremors); problems with balance and movement, such as trouble walking; trouble speaking or writing; confusion and disorientation; drowsiness, tiredness or lack of energy; muscle weakness; seizures; or memory loss. These may be symptoms of CRS or neurologic problems. If you have any symptoms that impair consciousness, do not drive or use heavy machinery or do other dangerous activities until your symptoms go away. EPKINLY can cause other serious side effects, including: Infections that may lead to death. Your healthcare provider will check you for signs and symptoms of infection before and during treatment and treat you as needed if you develop an infection. You should receive medicines from your healthcare provider before you start treatment to help prevent infection. Tell your healthcare provider right away if you develop any symptoms of infection during treatment, including fever of 100.4°F (38°C) or higher, cough, chest pain, tiredness, shortness of breath, painful rash, sore throat, pain during urination, or feeling weak or generally unwell. Low blood cell counts, which can be serious or severe. Your healthcare provider will check your blood cell counts during treatment. EPKINLY may cause low blood cell counts, including low white blood cells (neutropenia), which can increase your risk for infection; low red blood cells (anemia), which can cause tiredness and shortness of breath; and low platelets (thrombocytopenia), which can cause bruising or bleeding problems. Your healthcare provider will monitor you for symptoms of CRS, neurologic problems, infections, and low blood cell counts during treatment with EPKINLY. Your healthcare provider may temporarily stop or completely stop treatment with EPKINLY if you develop certain side effects. Before you receive EPKINLY, tell your healthcare provider about all your medical conditions, including if you have an infection, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. If you receive EPKINLY while pregnant, it may harm your unborn baby. If you are a female who can become pregnant, your healthcare provider should do a pregnancy test before you start treatment with EPKINLY and you should use effective birth control (contraception) during treatment and for 4 months after your last dose of EPKINLY. Tell your healthcare provider if you become pregnant or think that you may be pregnant during treatment with EPKINLY. Do not breastfeed during treatment with EPKINLY and for 4 months after your last dose of EPKINLY. In DLBCL or high-grade B-cell lymphoma, the most common side effects of EPKINLY include CRS, tiredness, muscle and bone pain, injection site reactions, fever, stomach-area (abdominal) pain, nausea, and diarrhea. The most common severe abnormal laboratory test results include decreased white blood cells, decreased red blood cells, and decreased platelets. In follicular lymphoma the most common side effects of EPKINLY include injection site reactions, CRS, COVID-19, tiredness, upper respiratory tract infections, muscle and bone pain, rash, diarrhea, fever, cough, and headache. The most common severe abnormal laboratory test results include decreased white blood cells and decreased red blood cells. These are not all of the possible side effects of EPKINLY. Call your doctor for medical advice about side effects. You are encouraged to report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch or to Genmab US, Inc. at 1-855-4GENMAB (1-855-443-6622). Please see Full Prescribing Information and Medication Guide , including Important Warnings. Globally, prescribing information varies; refer to the individual country product label for complete information. About Genmab Genmab is an international biotechnology company with a core purpose of guiding its unstoppable team to strive toward improving the lives of patients with innovative and differentiated antibody therapeutics. For 25 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with knock-your-socks-off (KYSO ® ) antibody medicines. Established in 1999, Genmab is headquartered in Copenhagen, Denmark, with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X . This Media Release contains forward looking statements. The words “believe,” “expect,” “anticipate,” “intend” and “plan” and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with preclinical and clinical development of products, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products or technologies obsolete, and other factors. For a further discussion of these risks, please refer to the risk management sections in Genmab’s most recent financial reports, which are available on www.genmab.com and the risk factors included in Genmab’s most recent Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC), which are available at www.sec.gov . Genmab does not undertake any obligation to update or revise forward looking statements in this Media Release nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law. Genmab A/S and/or its subsidiaries own the following trademarks: Genmab ®; the Y-shaped Genmab logo ®; Genmab in combination with the Y-shaped Genmab logo ®; HuMax ®; DuoBody ®; HexaBody ®; DuoHexaBody ®, HexElect ® and KYSOTM. EPCORE ®, EPKINLY ®, TEPKINLY ® and their designs are trademarks of AbbVie Biotechnology Ltd. i Campo, et al. TP53 Aberrations in Chronic Lymphocytic Leukemia: An Overview of the Clinical Implications of Improved Diagnostics. Haematologica . 2018 Nov 15;103(12):1956–1968. https://haematologica.org/article/view/8691 . ii Galieni, et al. Unmutated IGHV at Diagnosis in Patients With Early Stage CLL Independently Predicts for Shorter Follow-Up Time to First Treatment (TTFT). Leukemia Research. 2024. https://doi.org/10.1016/j.leukres.2024.107541 . iii Zuber, et al. Efficacy and Effectiveness Outcomes of Treatments for Double-Exposed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Patients: A Systematic Literature Review. Cancer Medicine . 2024. https://doi.org/10.1002/cam4.70258 . iv Fedele, et al. Chronic Lymphocytic Leukemia: Time to Care for the Survivors. Journal of Clinical Oncology . 2024. https://ascopubs.org/doi/10.1200/JCO.23.02738 . v Penn Medicine. Chronic Lymphocytic Leukemia (CLL). Accessed November 2024. https://www.pennmedicine.org/cancer/types-of-cancer/leukemia/types-of-leukemia/chronic-lymphocytic-leukemia . vi Odetola, et al. Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL). Curr Hematol Malig Rep . 2023 Jun 6:1–14. doi: 10.1007/s11899-023-00700-z vii Moreno, Carol. Standard Treatment Approaches for Relapsed/Refractory Chronic Lymphocytic Leukemia After Frontline Chemoimmunotherapy. Hematology Am Soc Hematol Educ Program . 2020 Dec 4;2020(1):33-40. doi: 10.1182/hematology.2020000086. viii Leukemia & Lymphoma Society. Relapsed and Refractory CLL. Accessed November 2024. https://www.lls.org/leukemia/chronic-lymphocytic-leukemia/treatment/relapsed-and-refractory . ix Engelberts PJ, et al. DuoBody-CD3xCD20 Induces Potent T-Cell-Mediated Killing of Malignant B Cells in Preclinical Models and Provides Opportunities for Subcutaneous Dosing. EBioMedicine . 2020;52:102625. doi: 10.1016/j.ebiom.2019.102625. View source version on businesswire.com : https://www.businesswire.com/news/home/20241208951291/en/ CONTACT: David Freundel, Senior Director, Global R&D & Portfolio Communications T: +1 609 430 2481; E:dafr@genmab.com Andrew Carlsen, Vice President, Head of Investor Relations T: +45 3377 9558; E:acn@genmab.com KEYWORD: DENMARK EUROPE INDUSTRY KEYWORD: RESEARCH FDA CLINICAL TRIALS BIOTECHNOLOGY HEALTH PHARMACEUTICAL OTHER SCIENCE SCIENCE ONCOLOGY SOURCE: Genmab A/S Copyright Business Wire 2024. PUB: 12/08/2024 11:00 AM/DISC: 12/08/2024 11:02 AM http://www.businesswire.com/news/home/20241208951291/en

Paul Sullivan: Leave it to the Bears to botch a coach firing even your Aunt Martha could see comingWashington Commanders place key weapon on injured reserve | Sporting News

Riley scores 18, Utah Tech beats Denver 68-54SAN DIEGO, Calif. — Central Washington may have finally found a signature nonconference win Saturday afternoon at the PLNU Tournament. The Wildcats found an antidote to some of their early season struggles and held off a late rally to win 69-68 at No. 13 Point Loma, a team ranked as high as sixth earlier this season. Garrett Anderson led the way with 17 points and Mitch Brizee contributed a double-double with 10 points and rebounds. A 13-0 run helped Central dig out of a 12-point hole in the first half and it led by as much as nine before the Sea Lions' Zack Paulsen hit three 3-pointers in the last 26 seconds. But two free throws by Anderson and another by Brizee ensured the Wildcats stayed in front. Central, which began the season ranked No. 15, opened the tournament with an 85-76 loss to Vanguard, despite 20 points and 11 rebounds from Garrett Anderson. The Wildcats (4-3) will return home to host Simon Fraser in their GNAC opener next Thursday night. CENTRAL WASHINGTON — Garrett Anderson 17, Jordan Clark 15, Mitch Brizee 10, Sanders 9, Holden 8, Parlin 6, Williams 2, Sisk 2, Kamalu-Vargas 0, Harris 0. 25-61 11-17 69. POINT LOMA — Anthony Tello 15, Bryson Metz 15, Jackson Larsen 14, Leonard Turner 12, Chiles 9, Carson Frawley 12, Momar Cisse 2, Ujadughele 2, Carson 2, Swartz 2, Johnson 0. 31-56 14-18 85. Halftime: 40-39 Vanguard. CWU highlights: Brizee 10 rebs; Anderson 7 rebs; Clark 4 assts; Sanders 4 stls. CENTRAL WASHINGTON — Garrett Anderson 20, Maverick Sanders 17, Cavin Holden 15, Clark 8, Brizee 4, Williams 8, Parlin 2, Sisk 2, Harris 0, Pepper 0. 24-58 21-26 76. VANGUARD — Zack Paulsen 20, Coby Barnes 12, Luke Haupt 11, Wynton Brown 10, Paulsen 4, Matingou 6, Hommes 5, Smith 0, Davis 0. 27-58 6-14 68. Halftime: 31-30 CWU. CWU highlights: Anderson 11 rebs; Sanders 7 rebs; Kobe Parlin 3 stls. YVC falls to No. 4 Skagit MOUNT VERNON — Yakima Valley couldn't keep up with No. 4 Skagit Valley in a 91-65 road loss Saturday night. Davis graduate Jose Brown and Zillah grad Clay Delp led the Yaks with 16 points each and former West Valley standout Jaxson Goldsmith added 13 points off the bench. Yakima Valley, which beat Peninsula 97-84 in its season opener Friday. YAKIMA VALLEY — Jose Brown 16, Clay Delp 16, Wright 6, Dorsett 4, Harris 2, Jaxson Goldsmith 13, Jones 6, Alvarado 2. 26-61 11-15 65. SKAGIT VALLEY — Bennett O'Connor 16, Amare Jackson 16, Sylas Williams 15, Gooding 7, Mkpa 7, Nickerson 9, Russ 9, Nelson 7, Howe 3, Wilson 2, Marong 0, Parker 0. 38-79 7-11 91. Halftime: 53-29 SVC. YVC highlights: Brown 7 rebs. Central rolls past Biola ELLENSBURG — The Central Washington women's basketball team continued its unbeaten start to the season thanks to strong defense in a pair of comfortable home wins at Nicholson Arena. Sunny Huerta scored a team-high 21 points to lead the Wildcats to a 59-48 win over Biola Saturday, the day after she posted a double-double with 11 points and 10 rebounds in a 54-36 win over Westminster. Central's defense held the Griffins to under 25% shooting from the field and gave up the fewest points by any opponent since a 48-32 win over Hawai'i Hilo in November 2016. Asher Cai tallied 18 points Saturday, including the last five points of a 12-0 run to begin the second half and put the Wildcats firmly in control. The standout junior guard also added four steals for a defense that has only given up 60 points once in its last five games. Central Washington (6-0) will begin conference play at home against Northwest Nazarene next Saturday. BIOLA — Sammie Henley 14, Jessa Thurman 12, Walker 7, Miller 6, Kamelamela 0, Goldsmith 9, Michel 0, Moran 0. 18-50 7-9 48. CENTRAL WASHINGTON — Sunny Huerta 21, Asher Cai 18, Coronado 6, Blodgett 6, Sims 2, Finch 4, Marsh 2, Smith 0, Demott 0, Leishman 0. 22-56 9-14 59. BU=16=9=10=13=—=48 CWU=10=15=17=17=—=59 CWU highlights: Huerta 6 rebs, 4 assts; Capri Sims 10 rebs; Cai 9 rebs, 4 stls. WESTMINSTER — Abby Conlee 11, Ellis 6, Nawahine 4, Harrigfeld 3, Rhay 2, Reed 4, Okada 2, Javillo 2, Aberle 2, Robinson 0, Tausinga 0, Staff 0. 14-57 7-10 36. CENTRAL WASHINGTON — Asher Cai 21, Sunny Huerta 11, Capri Sims 10, Coronado 4, Blodgett 0, Smith 3, Finch 3, Marsh 2, DeMott 0, Leishman 0, Shaw 0. 22-54 4-7 54. WC=15=10=3=8=—=36 CWU=15=11=14=14=—=54 CWU highlights: Cai 6 rebs; Huerta 10 rebs, 4 assts; Sims 7 rebs; Shelby Blodgett 3 stls. LA SALLE 92, RIVERSIDE CHRISTIAN 63: At La Salle, RIVERSIDE CHRISTIAN — Micah Morgan 20, Micah Rivera 20, Haydn Edwards 15, Bowden 2, Lee 0, C. Palma 3, Fry 2, Omlin 1, Johnson 0, J. Palma 0, Smith 0. LA SALLE — Hayden Brumback 29, Jaxton Caffrey 26, Aden Gonzalez 15, Aba Bocoum 14, Dufault 4, Abeyta 2, Mendoza 2, M. Berger 0, A. Berger 0. Riverside Christian=15=20=12=16=—=63 La Salle= WHITE SWAN 61, RIVERSIDE CHRISTIAN 43: At Riverside Christian, Daunte VanPelt recorded a double-double with 20 points and 16 rebounds to lead the Cougars to a season-opening win Friday night. White Swan lost 49-41 to Wahluke Saturday night, while Kittitas beat Granger 57-54, Yakama Tribal beat Highland 65-37 and La Salle beat Riverside Christian 92-63 in other nonleague matchups. In Saturday's girls basketball games, Kittitas beat Granger 50-11 and White Swan beat Wahluke 74-21 one night after knocking off Riverside Christian 74-21. WHITE SWAN — Daunte VanPelt 20, Jeff Bill 12, Braden Blodgett 11, Scabbyrobe 6, Shavehead 3, Sampson 4, Jaramillo 0, Saina 0. RIVERSIDE CHRISTIAN — Haydn Edwards 16, Norgon 7, Rivera 7, Klee 5, Bowden 0, Fry 4, Dalin 4, Palma 0. White Swan=6=18=22=15=—=61 Riverside Christian=10=12=7=14=—=43 WS highlights: VanPelt 5 rebs, Blodgett 9 rebs, 5 assts; Jeff Bill 12 rebs; Jaydn Scabbyrobe 7 rebs, 4 assts.

Ireland ran out 22-19 winners in Dublin but the Wallabies have restored pride on their European tour, after a dismal World Cup campaign last year. Australia had chances to win and looked a thoroughly different side to the one that was thumped 40-6 by Wales in September last year. Coach Joe Schmidt has shown the Wallabies have enough firepower to challenge the British and Irish Lions next year when at one stage it looked like the upcoming series would be a completely one-sided affair. How Australia’s players fared against Ireland 1) James Slipper - 6.5 Gave his all for 50 minutes but was penalised for collapsing a scrum just before half-time that led to an Ireland three-pointer. In Dublin in 2022, Slipper made the bold call that he wanted to play against the Lions and at 36 next year, looks set to do so. 2) Brandon Paenga-Amosa - 7 Australia didn’t lose a lineout all night, with Paenga-Amosa having a pleasing end to the tour. It was a major improvement from last week against Scotland. Jake Gordon sprints away for the Wallabies. Credit: AP 3) Taniela Tupou - 7.5 Picked off an intercept and streaked down the field but threw a loose pass to ruin the good work. His scrum work was good but certainly not dominant like we know he can be. Came off after 45 minutes in a more polished performance than some this year. 4) Nick Frost - 6.5 Second on the tackle count for Australia (17). Won five lineouts, the same as Ireland’s James Ryan and Tadhg Beirne. Was excellent in Dublin two years ago and backed that up here. Involved in a nice breakaway link play with Harry Wilson that once again highlighted Frost’s athleticism. 5) Jeremy Williams - 6.5 A solid 59-minute shift from someone who was not in the Wallabies frame last year. Did his job at the lineout and will feature next year against the Lions after a good spring tour. 6) Rob Valetini - 8 Valetini’s bad games are few and far between. Made 14 carries - four more than any other Australian player - to go with 10 tackles. Was almost yellow-carded for a forearm while carrying the ball into his former Brumbies teammate Mack Hansen. Pictured next to Hansen after the match, with the latter enjoying a Guinness. 7) Fraser McReight - 8.5 One of his best games in a gold jersey. Pulled off three turnovers at critical moments that gave the men in gold a major energy lift. Only blemish was an inaccurate, rushed pass to Tom Wright that was put down with four minutes to go with the Wallabies searching for a match-winning try. Tim Horan described McReight’s timing at breakdowns “amazing”. Topped the tackle count with 21. 8) Harry Wilson - 7.5 The sight of red headgear in space is becoming more common as Wilson and Frost combined with Ireland on the back foot. 13 tackles and 10 carries rounded out a productive day for the skipper. After not featuring for the Wallabies at last year’s World Cup, it has been some turnaround. 9) Jake Gordon- 7 A reasonable 61-minute shift with no major issues. Kicked high in midfield for Suaalii, a play which we could see more of during the Lions series. Service was solid as always and gets to rucks quickly. 10) Noah Lolesio - 7 Nailed all his kicks at goal, including a 48-metre penalty in the final quarter of the match. His wrap-around and service out the back in the lead-up to Jorgensen’s try was outstanding and shows what he’s capable of at this level. The Wallabies have lost their final game of 2024 to Ireland. Credit: AP 11) Max Jorgensen - 7 Finished off a nice team try in the 18th minute to put Australia up 8-0 but barely got his hands on the ball after that. Eight tackles across his 80 minutes. 12) Len Ikitau - 7 Tried to get into the game but didn’t have as big an impact as other games on the tour. Is No.12 his best position? Jury is out. How the Wallabies backline shapes for the Lions will be fascinating. Made more tackles than any Wallabies back (13). 13) Joseph-Aukuso Suaalii - 6 Certainly not as spectacular as he was on debut. Put a huge shot on Keenan early. Not as effective winning balls back from restarts. Five carries for 15 metres. Threw the ball away with three minutes to go and the Wallabies searching for a five-pointer. Got found out a few times defensively in the notoriously difficult No.13 channel. 14) Andrew Kellaway - 7 Ever reliable. Won a turnover and made nine carries for 25 metres. Great try-saving tackle that knocked the ball clean out of an Ireland player’s hand. 15) Tom Wright - 6.5 Standard showing without any major highlights. Ran the ball for more metres (42) than any Wallaby. Threw the final pass for Jorgensen’s try. 16) Billy Pollard - 5: No dramas with any throws after coming on with 23 minutes to go. 17) Isaac Kailea - 5.5: A late replacement with Angus Bell ruled out ill. Footwork into contact a highlight. Made eight tackles in his 30-minute stint on the park. 18) Allan Alaalatoa - 6: Did his job and the stuff no one looks closely at. Gave Ireland prop Cian Healy a hard time. 19) Lukhan Salakaia-Loto - 5: Came on with 21 minutes to go. No real highlights. Seven tackles. 20) Langi Gleeson - 5: Same boat as Salakaia-Loto, coming on with six minutes to go. 21) Tate McDermott - 6: Ireland kept a close eye on McDermott in a period where the home side had a lot of the ball. 22) Tane Edmed - n/a: Beaming with pride at becoming Wallaby No.709, Edmed’s debut only lasted three minutes as he came off for a Head Injury Assessment. He looked shattered. “Are you serious?” Edmed said as he walked off. 23) Harry Potter - n/a: Came on with 95 seconds to go. Not enough time for any wizardry.CWTI Provides Revised Update on Canada Postal Strike Delay Mailing of the Company’s 2024 Annual General Meeting MaterialsOhio State, Michigan players involved in postgame scuffle

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