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AP Sports SummaryBrief at 5:30 p.m. ESTFormer Mansfield MP Ben Bradley misses out on Tory mayoral nomination to Rob WalthamGeorgia QB Carson Beck's status for Sugar Bowl uncertain as he considers treatment options on elbow
KNOXVILLE, Tenn. (AP) — Nico Iamaleava threw for 209 yards and four touchdowns to lead No. 10 Tennessee to a 56-0 victory over UTEP on Saturday. The Volunteers (9-2) overcame a sluggish start to roll up the impressive win. Both teams were scoreless in the first quarter, but Tennessee found its rhythm. Grad student receiver Bru McCoy, who hadn't caught a touchdown pass this season, had two. Peyton Lewis also ran for two scores. “Once we settled in and did the ordinary things, we had a real good day,” said Tennessee coach Josh Heupel, whose team scored touchdowns on all eight red zone visits. “We started off cold,” said Iamaleava. "We made too many errors. We picked it up as the game went on. “That first play (of the Vols' first series of the game — a long incomplete pass to Squirrel White) we missed for a touchdown. I really want that one back. All you can do is focus on the next play.” Tennessee's defensive line, which had no sacks in last week's loss to Georgia, had four against the Miners. UTEP (2-9) struggled with two missed field goals and three turnovers. It was the second time in Miners coach Scotty Wallen's seven-year coaching career that his team has been shut out. “I thought we took massive steps forward, even though the results weren't what we wanted,” said Wallen. “(Tennessee) is one of the best teams in the country, right there.” Just before halftime, UTEP lost starting quarterback Skyler Locklear with an injury. Backup JP Pickles had trouble getting anything going. “When Skyler went down, that kind of messed with us,” said Miners center Brennan Smith. Tennessee's offense came alive with 28 points in the second quarter. In the final four drives of the quarter, Iamaleava completed 11 of 12 passes for 146 yards and touchdowns to White, Ethan Davis and McCoy. “(That first touchdown) was special for me,” said McCoy. "I promised my mom I'd get into the end zone. I never worried (this season, about not scoring). You have to have faith. The timing will be right for it to happen.” UTEP was the dominant team in the first quarter. Tennessee managed just 37 offensive yards and, thanks to an interception near the end zone and a missed field goal by the Miners, both teams were scoreless after 15 minutes. POLL IMPLICATIONS Tennessee’s convincing victory, coupled with losses by Mississippi and Indiana, should put the Volunteers in a good position when the next College Football Playoff poll is released. The Vols were ranked No. 11 going into this week’s games. THE TAKEAWAY UTEP: The Miners will head into a very winnable game against New Mexico State having won two of their last five games. First-year coach Scotty Walden will try to build on that success in the offseason to help enhance his roster. Tennessee: Even a lopsided win won’t carry much weight where it means the most — in the College Football Playoff rankings. The Vols will have to rely on a convincing win against Vanderbilt next week, a team that has shown a lot of improvement this season, to help their standing for those coveted spots. UP NEXT UTEP: The Miners will finish their season at New Mexico State Saturday. Tennessee: The Vols will finish their regular season at Vanderbilt next Saturday. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football
Northern elders reject tax reform bill, warn of socio-economic crisisHowever, some state workers failed to return to their jobs and a United Nations official said the country’s public sector had come “to a complete and abrupt halt”. Meanwhile, streams of refugees crossed back into Syria from neighbouring countries, hoping for a more peaceful future and looking for relatives who disappeared during Mr Assad’s brutal rule. There were already signs of the difficulties ahead for the rebel alliance now in control of much of the country. The alliance is led by a former senior al-Qaida militant, who severed ties with the extremist group years ago and has promised representative government and religious tolerance. The rebel command said they would not tell women how to dress. “It is strictly forbidden to interfere with women’s dress or impose any request related to their clothing or appearance, including requests for modesty,” the command said in a statement on social media. Nearly two days after rebels entered the capital, some key government services had shut down after state workers ignored calls to go back to their jobs, the UN official said, causing issues at airports and borders and slowing the flow of humanitarian aid. Rebel leader Ahmad al-Sharaa, who was known by his nom de guerre Abu Mohammed al-Golani, also met with Prime Minister Mohammad Ghazi Jalali for the first time. Mr Jalali stayed in Syria when Mr Assad fled and has sought to project normalcy since. “We are working so that the transitional period is quick and smooth,” he told Sky News Arabia TV on Monday, saying the security situation had already improved from the day before. At the court of Justice in Damascus, which was stormed by the rebels to free detainees, Judge Khitam Haddad, an aide to the justice minister in the outgoing government, said that judges were ready to resume work quickly. “We want to give everyone their rights,” Mr Haddad said outside the courthouse. “We want to build a new Syria and to keep the work, but with new methods.” But a UN official said some government services had been paralysed as worried state employees stayed at home. The public sector “has just come to a complete and abrupt halt,” said Adam Abdelmoula, UN resident and humanitarian co-ordinator for Syria, noting, for example, that an aid flight carrying urgently needed medical supplies had been put on hold after aviation employees abandoned their jobs. “This is a country that has had one government for 53 years and then suddenly all of those who have been demonised by the public media are now in charge in the nation’s capital,” Mr Abdelmoula told The Associated Press. “I think it will take a couple of days and a lot of assurance on the part of the armed groups for these people to return to work again.” In a video shared on a rebel messaging channel, Mr al-Sharaa said: “You will see there are skills” among the rebels. The Kremlin said Russia has granted political asylum to Mr Assad, a decision made by President Vladimir Putin. Kremlin spokesperson Dmitry Peskov declined to comment on Mr Assad’s specific whereabouts and said Mr Putin did not plan to meet with him. Damascus was quiet Monday, with life slowly returning to normal, though most shops and public institutions were closed. In public squares, some people were still celebrating. Civilian traffic resumed, but there was no public transport. Long lines formed in front of bakeries and other food stores. There was little sign of any security presence though in some areas, small groups of armed men were stationed in the streets.
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The Maharashtra assembly elections saw several candidates winning by narrow margins, highlighting intense electoral battles across the state. In Malegaon Central, AIMIM's Mufti Mohammad Ismail Abdul Khalique narrowly defeated Asif Shaikh Rasheed by just 162 votes. Similarly, Maharashtra Congress chief Nana Patole won in Sakoli against BJP's Avinash Brahmankar by 208 votes. Other close contests included BJP's Manda Mhatre's victory in Belapur by 377 votes and Shiv Sena's Sanjay Gaikwad's win in Buldhana by 841 votes. Rohit Pawar and Dilip Walse Patil also retained their seats with slim margins for NCP. (With inputs from agencies.)NoneWASHINGTON (AP) — A person accused of accosting U.S. Rep. Nancy Mace in a Capitol Office building pleaded not guilty on Wednesday to a misdemeanor assault charge. Witnesses told police that James McIntyre, 33, of Chicago, shook Mace's hand in an “exaggerated, aggressive” manner after approaching the South Carolina Republican in the Rayburn House Office Building on Tuesday evening, according to a police affidavit. Mace, who is identified only by her initials in a court filing, posted a string of social media messages about the incident. She said she was “physically accosted” at the Capitol, and she thanked President-elect Donald Trump for calling her Wednesday morning to check on her condition. “I’m going to be fine just as soon as the pain and soreness subside,” Mace wrote. Mace declined to be treated by a paramedic after her encounter with McIntyre, who was arrested Tuesday by the Capitol Police, the affidavit says. Mace told police that McIntyre said, “Trans youth serve advocacy,” while shaking her hand. Last month, Mace proposed a resolution that would prohibit any lawmakers and House employees from “using single-sex facilities other than those corresponding to their biological sex.” Mace said the bill is aimed specifically at Delaware Democrat Sarah McBride — the first transgender person to be elected to Congress. A magistrate judge ordered McIntyre’s release after an arraignment in Superior Court of the District of Columbia. Efforts to reach an attorney for McIntyre weren't immediately successful. The Associated Press
MGX-001, utilizing a highly specific and efficient MG29-1 nuclease, exhibits no identifiable off-target editing MG29-1 nuclease targeting the albumin safe harbor locus showed no evidence of translocations in primary human hepatocytes Metagenomi Adenine Base Editor (ABE) demonstrates no detectable translocations and no significant genomic base composition differences in primary T-cells EMERYVILLE, Calif., Dec. 11, 2024 (GLOBE NEWSWIRE) -- Metagenomi, Inc. (Nasdaq: MGX), a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary gene editing toolbox, today presented a talk titled “Specific and efficient genome editing with metagenomics-derived tools for in vivo and ex vivo therapeutic applications” at the Nature Conference: RNA at the Bench and Bedside IV. “We believe the value proposition for single-dose gene editing therapies requires exquisite specificity characterization to ensure safety and efficacy. Today’s presentation highlights the precision of Metagenomi’s next-generation nucleases and ABEs, discovered through the company’s proprietary metagenomics platform and tailored for both in vivo and ex vivo therapeutic applications,” said Alan Brooks, SVP and Head of Preclinical. “MGX-001, Metagenomi’s development candidate for hemophilia A, which utilizes the novel nuclease MG29-1, exhibits no identifiable off-target editing using a series of orthogonal assays employed to evaluate potential off-target sites in the genome. The MG29-1 nuclease targeting the albumin safe harbor locus showed no evidence of translocations in primary human hepatocytes. For Metagenomi’s novel next-generation ABE for ex vivo cell therapy indications via multiplex editing, the data showed no detectable translocations and no significant genomic base composition differences in primary T-cells when compared to unedited cells. These examples demonstrate our strong capabilities in developing highly specific next-generation gene editing tools and support the company’s ability to potentially progress these systems toward the clinic for the benefit of patients.” About Metagenomi Metagenomi is a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary, comprehensive metagenomics-derived toolbox. Metagenomi is harnessing the power of metagenomics, the study of genetic material recovered from the natural environment, to unlock four billion years of microbial evolution to discover and develop a suite of novel editing tools capable of correcting any type of genetic mutation found anywhere in the genome. Its comprehensive genome editing toolbox includes programmable nucleases, base editors, and RNA and DNA-mediated integration systems (including prime editing systems and clustered regularly interspaced short palindromic repeat associated transposases (CAST)). Metagenomi believes its diverse and modular toolbox positions the company to access the entire genome and select the optimal tool to unlock the full potential of genome editing for patients. For more information, please visit https://metagenomi.co. Cautionary Note Regarding Forward‐Looking Statements This press release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions, include, but are not limited to, any statements relating to our growth strategy and product development programs, including the timing of and our ability to conduct IND-enabling studies, make regulatory filings such as INDs, statements concerning the potential of therapies and product candidates, and any other statements that are not historical facts. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in “Risk Factors,” in our most recent Form 10-K and our most recent 10-Qs on file with the Securities and Exchange Commission. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Contact: Simon Harnest - CIO, SVP Investor Relations IR@metagenomi.coClick celebrates significant growth milestones while introducing a new initiative to support and empower photojournalists in sharing authentic, impactful stories through the platform. SAN FRANCISCO , Dec. 11, 2024 /PRNewswire/ -- Click , a groundbreaking mobile app that fights misinformation by making it simple to capture and publish authenticated content, powered by the Nodle Network , has recently launched the Click Photojournalism Fellowship, to empower photojournalists to join Click's mission to build a more truthful future. Joining the fellowship will give photojournalists exposure of their work via the Click app and Nodle Network and allow each photojournalist to share their stories and their photos. Additionally, Click has just reached two growth milestones in its first year of operation, passing 50,000 users and over 1,000 new photos authenticated by Click daily. These follow Click's public beta launch in March. The Click camera app is currently available for download on both iOS or Android , and all content captured with Click can be accessed through the app and on Click's website at clickapp.com . The first two photojournalists to join the Click Fellowship are: "We're thrilled to collaborate with photojournalists, empowering them to share their authentic stories through Click. In an era where digital content authenticity is crucial, we're leveraging blockchain to support journalists in building transparency and trust. The Click Photojournalism Fellowship sets a new standard for credibility in journalistic content on social media," says Micha Benoliel , CEO and co-founder of Intergalactic Labs, the team behind Click and Nodle. Click aims to grow the fellowship to over 20 photojournalists in early 2025 and is currently seeking more photojournalist partners. Photojournalists who join the program will share their recent work via Click's blog (both Click and non-Click photos), that represent their photojournalistic perspective, share their journalist story and be promoted across the Click and Nodle communities. Journalists will also provide feedback on the Click app periodically via scheduled sessions with Click's team. To apply and join the fellowship, photojournalists can fill out this short application and share samples of their work. About Click: Click is a new mobile app empowering everyone to easily create authentic media content. Click is on a mission to combat misinformation and bring truthful photos and videos aka "Deep Reals" to everyone via immutable digital proofs of authenticity. With Click, you can confirm content is real and happened at a specific location, time and via a specific mobile device and camera. This is all made possible by ContentSign , Click's proprietary technology which proves the integrity of data from its moment of capture on-chain. Click is built on ZKsync , the leading Ethereum Layer 2 blockchain and is powered by the Nodle DePIN. Click supports the Coalition for Content Provenance and Authenticity (C2PA) and is a member of the Adobe-led Content Authenticity Initiative (CAI). Download Click on iOS or Android and visit us at clickapp.com to learn more and see recent press coverage. View original content to download multimedia: https://www.prnewswire.com/news-releases/click-camera-app-announces-new-photojournalism-fellowship-as-app-reaches-50-000-users-signing-1-000-authenticated-photos-daily-302329583.html SOURCE Nodle
From left, Hwang Dong-hyuk, Kim Ji-yeon and Lee Jung-jae attend Netflix's FYSEE Showcase Photocall for "Squid Game" Season 2 at TUDUM Theater, Nov. 3, in Hollywood, Calif., U.S. AFP-Yonhap Netflix's "Squid Game" Season 2 has been nominated for best drama at the 82nd Golden Globe Awards, making history as one of the few shows to secure a nomination prior to its release. According to the list of nominees announced by the awards Monday (U.S. time), the Korean survival thriller set for release Dec. 26 was nominated for the Best Television Series - Drama category. It will compete against Peacock's "The Day of the Jackal," Netflix's "The Diplomat," Prime Video's "Mr. & Mrs. Smith," FX/Hulu's "Shogun" and Apple TV+'s "Slow Horses." U.S. media outlets, including The Hollywood Reporter and Deadline, noted the rarity of a prereleased series receiving a nomination. The unusual move was made possible because Netflix submitted the series early to the Golden Globe jury, according to the reports. 'Squid Game' creator calls Season 2 'chilling reflection' of Korea's martial law chaos 2024-12-09 17:01 | Shows & Dramas PHOTOS 'Squid Game' becomes reality in Seoul 2024-12-09 17:52 | Photos Under the awards' rules, entries must air within the calendar year and be submitted to organizers by Nov. 4. The decision to release "Squid Game" Season 2 during the holiday season marks a break from traditional practices. Most U.S. broadcasters avoid debuting new content at the end of the year, but Netflix's timing allowed the series to qualify for this year's competition. The first season of the Korean thriller made waves at the 79th Golden Globes in 2022, earning three nominations: best TV drama, best actor for Lee Jung-jae and best supporting actor for O Yeong-su. O, who portrayed the elderly participant Oh Il-nam, became the first Korean actor to win a Golden Globe. The 82nd Golden Globe Awards will take place Jan. 5. (Yonhap)