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wolf casino washington Mumbai: When 45-year-old Kaustubh*, a Bandra (West) resident, was diagnosed with cancer in 2018, support poured in from family, friends and doctors. Even health insurance companies and their third-party administrators were quick with the paperwork. He found a similar response in 2021 when he met with an accident and needed a leg surgery. But the next year when he was diagnosed with HIV, all the well-wishers disappeared. "People are sympathetic with cancer as it's not considered to be the fault of the patient. But, for HIV, the patients are always blamed," he said. Kaustubh is one of the 40,658 people living with HIV-AIDS (PLHA) in the city who are on medication to ensure their viral load is too low to be recorded. He could be a poster boy for the Indian healthcare system's response to HIV, but instead he and other PLHAs are stuck in the same social crisis that emerged after the virus was detected in India 38 years back. For most PLHAs, stigmatisation and discrimination attached to HIV— which spreads due to unsafe sex, needles or blood transfusion— is a grim day-to-day reality. Kaustubh has now stopped visiting fancy hospitals; when he developed an infection on the leg that was operated on, he got admitted to BMC's Bhabha Hospital. Overcrowded public hospitals have their own problems, but Kaustubh doesn't have to fear being overcharged or denied insurance. His fear isn't unreasonable. "At private hospitals, the charges for HIV patients seeking unrelated treatments, procedures or consultations can be more than for other patients," said HIV/AIDS specialist Dr Ishwar Gilada. Hospitals justify this by saying they have to spend on special equipment and infection-control protocols to treat positive people. HIV care has evolved a great deal since Mumbai's Jaslok Hospital treated the first HIV case in 1986. A sizable number of the 25.4 lakh people living with HIV (PLHIV) in India now get free medicines. This year, Mumbai tested 7.3 lakh for HIV and found 3,383 to be positive while the rest of the state tested 24 lakh between April and Sept and found 7,234 positive cases. Doctors from the public health department say the numbers have been dropping every successive year. Dr J K Maniar, HIV specialist at Jaslok Hospital, said, "Things have certainly improved, at least in cities and towns if not in our villages. It is true that PLHIV are denied admission in hospitals and that needs attention, at the same time, the extent of help available to such patients has boomed with govt and civil society initiatives." For many like Kaustubh, though, the HIV status results in abandonment. A bioethics conference on stigma was held at KEM Hospital in Oct with Humsafar Trust's representatives. Its founder Suhail Abbasi told TOI: "While more and more people in the community are being open about their identities, there is still a lot of fear on opening up to their loved ones if they are HIV positive." Insurance companies were expected to be more accepting of PLHIV after Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (Prevention and Control) Act, 2017, which reads: "No person shall discriminate against the protected person on any ground including "the denial of, or unfair treatment in, the provision of insurance unless supported by actuarial studies". Kavi, a 62-year-old resident of Bandra, found out otherwise. He has had health insurance since 2005 and was diagnosed with HIV in 2010. When he sought insurance for a medical procedure for sinus in 2021, his provider refused. So, while PLHAs live longer and normal lives due to medication, and develop age-related ailments needing knee replacements, angioplasties or transplants, insurance cover is a grey zone. Gaurav Dubey, CEO of Livlong insurance, a brokerage house, said, "Even for unrelated treatments, hospital costs for HIV patients are comparatively more. Insurance companies are not incentivised enough to design tailored plans for HIV patients and there is ambiguity in prevailing laws." Ganesh Acharaya, the city's TB-HIV co-infection survivor and activist, said a few insurers offer coverage to PLHAs but the process is difficult. "Agents do not know the procedure. When I have tried approaching insurance companies, officials shut their doors on us." Jaanvi (32) who has lived with HIV since birth, has found a way around the insurance hassle. "The one time I needed a health procedure unrelated to HIV, I found a hospital that protected my HIV status from my insurance company." Nonetheless, there is hope. In 2021, Jaanvi took a leap of faith and revealed her status to a potential partner, who is not HIV positive. They married, have a healthy sex life with minimum transmission risk, and have a healthy kid. (*Names changed)Local Heroes awards: 'It captures Butte at its best'A Vermonter’s guide to navigating holiday stress

SAN JUAN, Puerto Rico (AP) — The U.S. territory of Puerto Rico has yet to produce a certified vote tally for a single district almost a month after holding historic general elections . Then on Wednesday, a judge issued a ruling that sparked an outcry and threatened to further delay the certification process as the Jan. 2 swearing in looms. The judge, in response to a lawsuit, ordered Puerto Rico’s State Elections Commission to count early votes following ID verification even if the postal address used to request those votes is different from the one in the general voter registration. “Contrary to what some actors in our society may have encouraged in public opinion, our legal framework in electoral matters is covered with guarantees of reliability, which leave no room for speculation or doubts about the validity of early votes,” Judge Raúl A. Candelario López wrote. The Nov. 21 lawsuit was filed by a dozen voters affiliated with the pro-statehood New Progressive Party, which won the gubernatorial race, according to preliminary results. The ruling noted that those voters alleged “their rights are being violated since they requested early voting, complied with all the requirements for it, and their votes are being subject to additional requirements without any legal basis.” The judge’s decision angered many including Karla Angleró, electoral commissioner for the opposing Popular Democratic Party, one of Puerto Rico’s two main parties, She said the party would appeal Wednesday’s ruling. In September, Angleró and electoral commissioners from other parties agreed that if they uncovered addresses that didn't match, officials would call people to confirm that they indeed requested an early vote to prevent any fraud. Angleró and other commissioners had recently requested that the elections commission investigate how more than 40 ballots with different residential addresses were requested from the same P.O. box in the southern coastal town of Santa Isabel. “We’ve been waiting for weeks,” she told reporters on Wednesday of the investigation. Judicial officials already are investigating allegations made before Nov. 2 about electoral crimes including people who said they received confirmations for early voting when they had made no such request. As those investigations continue, workers are certifying ballots with the aim to finish by Dec. 20 or 22, according to Jessika Padilla, alternate president for the elections commission. The aim was to finalize the district of the capital of San Juan on Wednesday, but that was pushed back to Sunday, she told reporters. Numerous obstacles have delayed the certification process, including an increase in write-in votes and a flurry of errors detected in bedside ballots, prompting all electoral commissioners to agree to start counting more than 60,000 such votes from scratch. The delay prompted electoral commissioners last week to temporarily halt the counting of ballots cast in a nonbinding referendum also held Nov. 2 on Puerto Rico’s political status so they could focus on election ballots. Local law dictates that the certification process must be completed by Dec. 31.Finding the the perfect holiday gift for everyone on your wishlist can be overwhelming, especially if you’re looking for a deal. Thankfully, Black Friday is here and you can score major discounts on everything on your Christmas shopping list from handbags to tech products and more. To make sure you find the best prices, we’ve compiled all the top Black Friday sales from A to Z — and everything in between. You’ll find big Black Friday sales at Coach , Crocs and Stanley . There’s even more deals at Amazon , Walmart and Nordstrom . Shop for big sneaker discounts at Hey Dude , HOKA and Nike . Plus, you’re not going to want to miss all the streaming discounts at Hulu , Disney+ and Paramount+ — just to name a few. There’s an endless list of Black Friday sales going on now and these are some of the best you’re going to want to shop now. The best Black Friday deals in 2024 A Abercrombie : MyAbercrombie Members get 25% off everything – and it is free to sign up ! As if 25% off isn’t enticing enough, Abercrombie has a fun little surprise waiting at checkout for Black Friday. You can use promo code WISHLIST for an extra 15% off. Alo Yoga : For Black Friday, Alo Yoga has brought back its popular 30% off sitewide sale . This includes markdowns on best-selling products like the 7/8 High-Waist Airbrush Legging for $75, instead of $108 or the Unisex Half-Crew Throwback Sock for $19, instead of $28. Plus, you’ll get free shipping and extended returns through Jan. 10, 2025. Amazon : Amazon’s Black Friday Sale kicked off Thursday, Nov. 21, and lasts through Monday, Dec. 2, with huge savings on top brands like Apple , Bose , Dyson , KitchenAid , Samsung , and more. Away : You can shop on AwayTravel.com for 25% off everything. We’re serious when we say everything, too, as the promotion extends site-wide — from best-sellers and fan-favorite luggage , both hard and soft-side, to travel bags and totes , packing extras , and just-landed launches in any silhouette, size, and color you’re crushing on. B Beis Travel : This huge Black Friday sale starts on Nov. 29 with sitewide discounts on Beis popular luggage pieces. You can also score a chance to grab up to 50% off select luggage in the Daily Flash Sale through Dec. 2 by joining the virtual cue at 11:30 a.m. ET. But all these rare luggage markdowns are only available while supplies last. Bloomingdales : For Black Friday, Bloomingdales is hosting 7 Days of Savings now through Sun, Dec. 1. Shoppers can save 25% on thousands of products. Brooks Running : Save up to 41% on select Brooks Running styles for Black Friday and Cyber Monday. Shop women’s and men’s styles to get markdowns on beloved sneakers, like the Adrenaline GTS 23 for 29% off or the Catamount 3 for 41% off. Buffy : During Buffy’s Black Friday sale , you can save 30% off everything sitewide, including best-sellers like the Breeze Sheet Set ($146, instead of $195) or the internet-famous Cloud Comforter ($146, instead of $195). C Casper : During Casper’s Black Friday sale , you can score up to 30% off all mattresses and up to 35% off everything else on Casper’s website. The Casper Snow Cooling Hybrid Mattress is currently $750 off during this promotion. Coach: Take an up to 40% off the best Coach handbag styles during this Holiday Sale , with deep discounts on satchels, shoulder bags, totes, crossbodies and more. Coach wallets, wristlets, shoes, clothing and accessories are also on sale for up to 40% off. Coach Outlet : Get an extra 25% off sitewide at Coach Outlet for Black Friday. You can get Coach wristlets for $41, Signature Canvas bags for under $100, wallets for under $70, and so much more. Converse : For Cyber Week, Converse has up to 50% off almost everything on site. You can find huge markdowns on over 500 styles, including one of the brand’s most popular styles, the Chuck Taylor All Star Lift Platform Canvas . Just use promo code CYBERWEEK at checkout. Crocs : Get up to 60% off for Croc’s “Bright Friday” sale , with deals on the Classic Clog (20% off select colors), the Mega Crush Sandal (50% off), the Brooklyn Buckle (25% off), and so much more. D Dick’s Sporting Goods : Get up to 50% off sneakers, athletic wear, sports equipment, outdoor gear and so much more from this massive Black Friday Now! sale . These deals extend to top athletic brands, such as Nike, HOKA, Brooks, Adidas, Hydro Flask, Stanley and more favorites. The sale runs through Dec. 2. Disney+ : You can get a Disney+ and Hulu bundle for a massive 70% off; you can get this ad-supported bundle for $2.99/month for 12 months during this Black Friday promotion. The offer is valid for new and returning customers. Disney Store : Disney’s big Black Friday sale has markdowns of up to 50% off. Everything sitewide is 25% off, with free shipping on orders of $40 or more with promo code GIFT . That includes a whopping 25% off Loungefly backpacks , Disney x Starbucks Christmas tumblers , and more. DSW : You can save up to 60% on a huge selection of styles during DSW’s Black Friday Sale . That includes UGG boots and slippers for up to 40% off, up to 30% off Nike , and up to 25% off select Adidas styles . Dyson : Save up to $300 on select Dyson technology for Black Friday . That includes major deals on Dyson vacuums, like the Dyson V12 Detect Slim on sale for $400, instead of $650. The Dyson Supersonic hair dryer is $330, instead of $430, plus it comes with a presentation case (worth $60) and two free gifts (worth $80). The Dyson Purifier Big+Quiet Formaldehyde BP04 is a whopping $300 off during this promotion. E Etsy : Big deals are dropping at Etsy with up to 60% off at participating shops in a Cyber Savings Spectacular. This includes gift ideas for kid’s, pet presents, holiday decor, home finds, personalized gifts and more unique picks. Expedia : Save on travel with this Black Friday sale that offers 30% off or more for One Key members at select hotels through Dec. 4. You can sign up to become an Expedia One Key member for free online and you’ll also receive more savings through out the year. F Fanatics : Shop this Holiday Savings Event and save on a sports apparel and gear, including jerseys from your favorite team, using the promo code GIFT . There are also Holiday Doorbusters up to 50% off on hats, hoodies T-shirts and more. Fossil : Take up to 30% off almost everything for Black Friday through Dec. 8. Save on watches, handbags, wallets, jewelry and other holiday gifts. G GAP : This Black Friday Sale is offering 50% off sitewide, with “really big deals” that are marked down 60% off or more through Nov. 29. You can shop discounted sweaters, sweats, pajamas, jeans, accessories and much more during this huge holiday sale. Gilt : Save on designer finds as a Gilt member with deep discounts up to 75% off or more on top brands like Canadian Goose, Gucci, Burberry, Saint Laurant, FENDI and other favorites. But these limited-time sales go fast, so you’ll want to grab these low prices when they drop and before they’re sold out. Glossier : You can save 25% off almost everything for Glossier’s Black Friday Sale , but the more you spend, the more you save! You’ll unlock 30% off when you spend over $100 or more during this sale. Gravity Blankets : For Cyber Week, Gravity Blankets is running up to 70% off everything promotion, with the Gravity Weighted Blanket costing only $95, instead of $250, during this sale . H Hey Dude : Take up to 60% off almost everything for Black Friday using the promo code CYBER, including those beloved Wally and Wendy sneaker styles. You’ll also want to check out the Doorbuster deals that start at just $30, HOKA : Shop for the best HOKA sneaker deals up to $72 off, including the ever-popular Bondi 8 in more than 30 color options and the top-selling Clifton 9 sneaker. But the markdowns in this huge Black Friday sale are selling fast, so you’ll want to grab your favorite before it disappears. The Home Depot : For Black Friday , Home Depot is running flash sales daily through the end of November, with thousands off of appliance packages. You can get DEWALT power tools on sale , HUSKY tool kits , and so much more. Hydro Flask : Take 30% off Hydro Flask’s online exclusive drinkware styles but only for a limited time. This includes its popualr water bottles and Travel Tumblers in top colors, like Mint, Eggplant, Clementine and more favorites. Hulu : Eligible new and returning subscribers can get this year’s Hulu Black Friday deal which offers Hulu (With Ads) for just $0.99/month for a year, a savings of over $100 for the year. I Indochino : Custom suits are starting at just $329 during Indochino’s Black Friday sale. Plus, you can get an extra 25% off two suits from the Harrogate collection when you use promo code BLKFRI24 . J J. Crew : Shop this Black Friday Event for up to 50% off almost everything, including clothing and shoes for men, women and children. You can also take an extra 50% off already reduced styles. K Kate Spade : You can save up to 50% off during Kate Spade’s Black Friday Preview Sale . This includes designer handbags, jewelry, wallets, and more. Kate Spade Outlet : Save on handbags, wallets and more during this Black Friday Sale with markdowns up to 70% off and an extra 25% off everything. You can also shop the Black Friday Deal of the Day and discounts on jewelry, shoes and more. Kohl’s : Shop these Black Friday Deals and take an extra 15% off with coupon on select finds for the holidays through Nov. 29. You’ll also earn $15 in Kohl’s Cash for every $50 spent with free shipping on online orders over $25. L Litter Robot : For 2024, our favorite robot litter brand , Litter Robot, has $100 off select Litter Robot bundles , 30% off new subscriptions, and 35% off 2+ new subscriptions for Black Friday. M Macy’s : This Black Friday Sale has the top deals the whole family, including 50-65% off coats, boots starting at $20, LEGO sets for 20% off, Ninja appliances for 20-50% off and more. You can also save on Macy’s Parade of Deals with a new daily deal dropped each day. Max : One of the best streaming Black Friday deals we’ve seen so far is this Max offer . You can save 70% on memberships, with prices starting at $2.99 per month with ads for six months. N Nike : Get up to 60% off must-have holiday gift items at Nike during the Black Friday Early Access sale, when you use promo code ACCESS at checkout. NinjaKitchen : Ninja is offering up to 48% off select best-selling products for Black Friday , plus exclusive bundles for the holidays. The Ninja WoodfireTM Outdoor Grill & Smoker is $270, instead of $490, plus it comes with a free grill stand. Ninja is one of the few places that actually has the SLUSHi in stock and not price-gouged. Nordstrom : The early Nordstrom Black Friday sale has top holiday deals of up to 60% off on big brands, including HOKA , Dyson , Tumi , Ralph Lauren , UGG , and more. Nordstrom Rack : Nordstrom Rack has up to 70% off unbeatable deals for Black Friday , with huge markdowns on top brands including Kate Spade, UGG, and more. The North Face : During North Face’s Black Friday sale , you can get up to 30% off select styles, including the Women’s Explore Farther Parka and Men’s Explore Farther Parka for $90 off. O Oura : The Oura Ring is down to its lowest price ever for Black Friday, with up to $200 off Oura Ring Gen3 (now $249). Our Place : The Our Place Black Friday Sale has a staggering 40% off top-selling products, like the Always Pan ($95, instead of $150) and Perfect Pot ($105, instead of $165). Plus, Our Place is hosting daily flash deals for extra savings during Cyber Week. Owala : The Merry & Bright Collection of water bottles and tumblers is still available for purchase for a special-edition holiday gift. You can shop Owala’s full lineup of drinkware, including its beloved FreeSip and FreeSip Twist water bottles in a extensive array of color options P Paramount + : For Black Friday, Paramount+ has up to 76% off. This limited-time Black Friday offer gets you access to Paramount+ Essential OR Paramount+ with SHOWTIME for $2.99/month for the first 2 months. This is eligible for new and former subscribers. Peacock : You can save 75% on an annual membership during this Peacock 2024 Black Friday offer . You have two options, you can either get a whole year of Peacock for just $19.99 or get $1.99/mo for 6 months. Q Quay : For Black Friday, Quay has brought back its popular BOGO offer. When you buy one, you’ll get one free during this Quay Black Friday promotion . R REI : There are a flurry of Cyber Deals to shop at REI, including big discounts on outdoor apparel, shoes, camping gear, cycling gear, climbing gear and other outdoor essentials. This includes deals on HOKA, Altra, Garmin, Columbia, The North Face, Patagonia, Marmot and more favorite brands. Plus, more markdowns will drop on Nov. 30. S Samsung : Save up to $1,700 during Samsung’s Black Friday Sale on the popular OLED TV . There are huge markdowns on refrigerators as well, with up to $1,700 off Samsung fridges . Shark : Receive $350 off Shark MatrixTM Plus 2-in-1 Robot Vacuum and Mop with XL HEPA Self-Empty Base and a free gift Shark® WANDVACTM Cordless Handheld Vacuum with purchase, which is a $130 value . Stanley : Get 25% off select best-selling Stanley products , including The AeroLightTM Transit Bottle and The IceFlowTM Flip Straw Jug when you use the promo code BLACKFRIDAYSALE25 at checkout. T Target : Target’s official Black Friday sale is here and live now through Saturday, Nov. 30 , while supplies last. Kitchen appliances and dining items are up to 50% off, though in some rare cases, you’ll find up to 69% off, like this Henckels Knife Block Set . You can also get up to 50% off a number of vacuum and floor care products , like this Dyson stick vacuum which is 50% off and down to $250. Tory Burch : Take 30% off your purchase of $250 or more during this Holiday Event . This includes savings on handbags, shoes and fashion, with even more markdowns continuously added to the sale. The discount is automatically applied at checkout. U UGG : UGG is offering up to 70% off a slew of UGG styles , including those popular slipper and boot designs we’ve been waiting for all year to go on sale. This includes major discounts on UGGs for men , women , and children . We’re seeing over 200 markdowns for Black Friday, including on popular Women’s Tazz styles and Men’s Tasman styles. Ulta : Get up to 50% off new Black Friday deals from Ulta. You can shop discounts on hair products, styling tools, fragrances, skincare products, makeup, nail essentials and other markdowns. V Vera Bradley : Get 30% off almost everything when you shop Vera Bradley’s Black Friday sale . Plus, new customers will get an extra 20% off their first order when they sign up for text rewards. Victoria’s Secret : Fortunately, Victoria’s Secret and its sister brand, PINK , have our backs. Now through Nov. 25, you can shop the “Black Friday Energy” sale at both sites for 30% off nearly everything (clearance items, non-VS brands and select product categories, like swimwear, may be excluded): sleepwear , loungewear , activewear , underwear , accessories , beauty and fragrances , gift sets and more. W Walmart : The biggest sales day of the year is coming to Walmart this week. Starting Nov. 25, you can score huge Black Friday savings at Walmart on brands like Dyson, Apple, and Shark. Select Smart TVs will be on sale for hundreds of dollars off. Wayfair : Now through Dec. 3, you can shop Wayfair’s Black Friday sale for everything you need to make your home the one everyone wants to hunker down in. Sleeper sofas, spacious sectionals , slumber-worthy memory foam mattresses , snuggly throws, comforters, pillows , and more are all marked down up to 80% off . X X-Chair : Save 25% off everything on the website, including $475 off office chairs during this Cyber Sale . You can also shop desks, tables and other office accessories at a discount online. Y RECOMMENDED • nj .com Dick’s Sporting Goods Black Friday sale has HOKA, Nike, New Balance, more top sneakers up to 50% off — but on Nov. 26, 2024, 2:15 p.m. UGG just dropped its huge Black Friday sale with up to 70% off, including Tasman slippers — but these deals w Nov. 27, 2024, 6:55 a.m. YETI : The Yeti Gear Garage is now open with exclusive daily drops for the next six days, including rare gear and limited-edition picks and more. You’ll find Tundra coolers, Rambler drinkware and more outdoor necessities. Plus, you can save 20% off the seasonal King Crab Collection while supplies last when you sign into your Yeti account. Z Zappos : Huge deals on shoes and fashion are available online for Black Friday . You can shop sneakers for up to 60% off, boots up to 40% off, coats up to 60% off, slippers up to 60% off and tons of Daily Deals for up to 50% off from several popular brands.

TORONTO (AP) — Mark Scheifele scored a hat trick and an assist while Kyle Connor collected two goals and an assist to spark the NHL-leading Winnipeg Jets to a 5-2 win over the Toronto Maple Leafs on Monday. The Jets enter the Christmas break with back-to-back wins, while the Maple Leafs dropped their second in a row at Scotiabank Arena without wounded captain Auston Matthews, out with an upper-body injury. Gabriel Vilardi added three assists. Jets goalie Connor Hellebuyck made 23 saves. Jets defenseman Josh Morrissey had two assists to reach 30 for the season. John Tavares scored twice for the Maple Leafs, and Joseph Woll stopped 22 shots. Maple Leafs forward William Nylander extended his point streak to seven games with assists on both of Tavares' goals. Toronto: Defender Chris Tanev missed his first game this year with a lower-body ailment after skating in the pre-game warmup. Winnipeg: As impressive as the Jets (25-10-1) have played before the break, they are only one point ahead of the 36-game pace of 23-9-4 set a year ago. After Jets defenseman Neal Pionk had his shot blocked, the puck bounded to Mitch Marner for a breakaway. Pionk hustled back to lift Marner’s stick to foil his shot attempt early in the second period to preserve Winnipeg’s 2-0 lead. The Maple Leafs have gone 7-4-0 with Matthews on the sidelines this season and 42-23-2 in his career. Toronto returns to action after the holiday break on Friday, visiting the Detroit Red Wings. On Saturday, the Jets host the Ottawa Senators. AP NHL: https://apnews.com/hub/nhlmade history a year ago this month when the FDA approved Casgevy (exagamglogene autotemcel), the CRISPR-edited therapy it co-developed with , to treat sickle cell disease (SCD). A month later, the agency authorized Casgevy to treat transfusion-dependent beta thalassemia in patients 12 years and older. Yet CRISPR Therapeutics’ stock has failed to sustain the momentum it built when it reached its 52-week high of $91.10 on February 22, a day after the company reported positive fourth-quarter and full-year 2023 results. Since then, Casgevy’s patient uptake has progressed slower than analysts expected. While some have cited Casgevy’s list price of $2.2 million per course of treatment as a cost that insurers have balked at bearing, Kevin Niehoff, associate director at IPD Analytics told Managed Healthcare Executive (MHE) he believed price was less a barrier than the fact that SCD patients have many other treatment alternatives, such as stem cell or bone marrow transplants, as well as hydroxyurea. From a 52-week high of $91.10 on February 22, CRISPR Therapeutics shares have to $49.51 as of Thursday, though they Friday to $51.56 in afternoon trading as of 2 p.m. ET. Over the past month, two electronic transfer funds (ETFs) of ARK Investment Management (ARK Invest)—the high-profile firm led by chief investment officer and portfolio manager Catherine D. (Cathie) Wood—have largely been swimming against the investor tide by snapping up more than 1 million shares of CRISPR Therapeutics shares, mostly raising its stake in the company in recent weeks. From a reported market value of $352,285,403 at the end of the third quarter, ARK’s holdings in CRISPR Therapeutics climbed 16% to $409,634,402.21 as of Friday, based on its holdings of 8,273,771 shares. Most of ARK’s stake in CRISPR Therapeutics consists of the 6,453,394 shares held by Ark Invest’s , with a market value of $319,507,536.94—the seventh highest market value among the 33 companies in which ARKG holds shares—and a portfolio weight of 4.56% The remaining 1,820,377 shares valued at $90,126,865.27 are held by the firm’s . CRISPR Therapeutics holds the second largest market value among ARKG’s 37 portfolio companies—and a portfolio weight of 7.68%. Without citing CRISPR Therapeutics by name, Wood offered a likely explanation on a recent podcast for why the ARK ETFs have been bullish on the company in recent weeks. “Many healthcare analysts think that curing a disease is not going to be good business, even though it’s amazing for humanity. They think that a cure is one and done, which it is with gene editing,” Wood observed on the November 25 episode of “The Important Part: Investing with Liz Thomas.” “The old model is almost like an annuity, a regular payment monthly for that prescription, out for however long the patent lasts. We believe a cure in business terms is going to be worth two to—depending on the indication—20 times more valuable than a traditional medication,” Wood projected. “So, stay tuned for our research. We’re putting out a lot in that area because we believe it is so misunderstood.” A closer look between Wednesday and Friday, however, shows that the ARK funds followed dips in CRISPR Therapeutics’ share price late last week with selloffs of shares in the company. On Thursday, when CRSP shares from $51.24 to $51.14, ARK trimmed its holdings by 5,864 shares (down 0.1% from Wednesday), reducing its total market value by 0.3% or $1,135,639.78. But by Friday, when the stock to $49.51, ARKK and ARKG shrunk their combined holdings by 78,936 shares (down nearly 1% from Thursday), a market value decline of 4% or $17,523,136.05. So as with other investors, the ARK funds appear to have moved beyond the positive commercial momentum for Casgevy shown in third-quarter results released last month by CRISPR Therapeutics and Vertex. Vertex leads global development, manufacturing, regulatory and commercialization of Casgevy, with support from CRISPR Therapeutics. According to Vertex: • As of mid-October, 45 of the planned 75 authorized treatment centers (ATCs) have been activated in all regions of the world where Casgevy has been approved—the U.S., the European Union, Great Britain, Saudi Arabia, Bahrain, Canada, and Switzerland. • Cell collection had begun in about 40 patients, double the approximately 20 reported after the second quarter, while additional patients have received infusions. • The first $2 million in revenue has been generated from the first commercial patient dosed with Casgevy during Q3. That revenue was included within the $2.772 billion in product revenue that Vertex reported for the quarter. “We view the Casgevy progress as a (+)ve [positive] indicator of getting pts [patients] in the funnel, and expect a majority of ~40 pts will get tx’d [treated] w/in 1–2 quarters,” Maury Raycroft, PhD, equity analyst with Jefferies, projected in a November 5 research note. “It can take ~5–6mos from cell collection to tx. Pt demand is high, and VRTX is adding a 3rd manuf[acturing] facility w/ Lonza.” Raycroft added that Casgevy’s opportunity to attract patients in the Middle East region was “underappreciated and appealing,” with about 23,000 patients eligible. Following a meeting between CRISPR Therapeutics executives and Jefferies analysts at the firm’s London Healthcare Conference late last month, Raycroft reported that management “is pleased w/ how the ‘funnel’ trajectory is playing out commercially as underlying demand/interest has been very strong WW [worldwide] along w/ payer support. It’s only a mechanics question now as more centers get activated.” Writing in a November 20 research note, Raycroft and four Jefferies colleagues reported CRISPR Therapeutics executives expect momentum to build up in coming months, referring to the slow but steady and gradually progressing launch of Yescarta (axicabtagene ciloleucel), the chimeric antigen receptor T-cell (CAR-T) cancer treatment marketed by the Kite subsidiary of following FDA approval in 2017. CRISPR Therapeutics executives told Jefferies analysts the market potential for Casgevy stems from the presence of some 25,000 severe SCD patients in the U.S., another roughly 30,000 in the Middle East, and unspecified growing numbers in the U.K. & France than originally envisioned. In its third-quarter investor presentation, CRISPR Therapeutics pinpointed about 23,000 patients in Saudi Arabia and Bahrain alone, plus about 35,000 patients in the U.S. and Europe combined. “Mgmt [management] noted two areas, where they continue to invest are on global extension and capacity expansion, anticipating the demand,” Raycroft wrote adding that 2024 Casgevy-related expenses have been trending around ~$0.5 billion. Vertex shoulders 60% of costs and enjoys that percentage of profits, with the remaining 40% of costs and profits going to CRISPR Therapeutics. Also positive on Vertex’s commercial progress with Casgevy has been analyst Sami Corwin, PhD, and two colleagues at William Blair. “We view the treatment of the first commercial Casgevy patient as a milestone for the companies and believe they have established the infrastructure to support significant revenue generation in 2025 as more cell collections are converted into cell infusions,” Corwin and colleagues wrote November 5 in a research note. • shares from 74 cents to 49 cents in after-hours trading Wednesday after the company said it will carry out a 1-for-20 reverse stock split following approval by both its board and stockholders at a reconvened annual meeting held that day. Bluebird acknowledged that its primary goal is to increase the per share market price of its common stock to regain compliance with NASDAQ’s minimum bid price requirement for continued listing. The reverse stock split is expected to become effective at 5 p.m. ET on December 12, and the first reverse-split shares will start trading the following day. The drop partially wiped out a 105% gain earlier that day, from 36 cents to 74 cents, after the company announced that it reached agreement with the Center for Medicare and Medicaid Innovation(also called the CMS Innovation Center) to offer an outcomes-based agreement for the gene therapy LyfgeniaTM (lovotibeglogene autotemcel) under the Cell and Gene Therapy Access Model. • shares from $20.04 to $29.85 on December 2, after the company joined Zai Lab (NASDAQ: ZLAB; HKEX: 9688) to announce positive topline results from the pivotal Phase III PANOVA-3 trial (NCT03377491) assessing its Tumor Treating Fields (TTFields) therapy as a first-line treatment for unresectable, locally advanced pancreatic adenocarcinoma. TTFields met the study’s primary endpoint by showing a statistically significant improvement in median overall survival (mOS) versus gemcitabine and nab-paclitaxel alone, Novocure said. In the intent-to-treat population, patients treated with TTFields plus gemcitabine and nab-paclitaxel had an mOS of 16.20 months vs. 14.16 months in patients treated with gemcitabine and nab-paclitaxel alone. • shares from $3.36 to $8.40 on December 2 after the company reported positive final results from the randomized Phase II trial (NCT04731467) evaluating its lead oncology drug CM24 in patients with pancreatic ductal adenocarcinoma (PDAC). Those results showed a consistent and continuous decrease of the PDAC biomarker CA19-9 in the experimental arm reaching a median percentage reduction from baseline of approximately 80%, vs. a 40% increase in the control arm. The trial assessed CM24—a humanized monoclonal antibody designed to block CEACAM1—in combination with Bristol Myers Squibb’s immune checkpoint inhibitor Opdivo (nivolumab) plus standard-of-care (SoC) chemotherapy in second-line metastatic PDAC patients vs. SoC chemotherapy alone. • shares over two days after the company said it will evaluate potential next steps for REL-1017 after acknowledging that the NMDA inhibitor was unlikely to meet with statistical significance the primary efficacy endpoint of the Phase III Reliance II trial (NCT06011577), which is assessing the drug for use in combination with other approved anti-depressants for major depressive disorder (MDD). The trial’s Independent Data Monitoring Committee (DMC) concluded during a pre-planned interim analysis that continuing Reliance II would be futile. Shares from $2.77 to 63 cents Wednesday, then Thursday to 45 cents after Mizuho Securities analyst Uy Ear downgraded the stock from “Outperform” to “Neutral” and slashed the firm’s 12-month price target 96% from $23 to $1. • shares from 95 cents to 51 cents Tuesday after the company said it entered into a definitive agreement to immediately exercise warrants to purchase up to 4,064,040 shares of common stock issued by the company on August 22, at $1 per share. The sale is designed to generate more than $4 million in gross proceeds—about double the company’s $2.168 million market capitalization. A day earlier, Revelation shares rose 25% after the FDA accepted the company’s investigational new drug (IND) application for Gemini, a proprietary formulation of phosphorylated hexaacyl disaccharide (PHAD ). The decision allowed Revelation to launch a U.S.-based Phase Ib trial assessing Gemini as a preconditioning treatment in patients with chronic kidney disease. Revelation shares have cratered 98% over the past year, from $22.95 on December 4, 2023.

SHAREHOLDER INVESTIGATION: Halper Sadeh LLC Investigates ALTR, SASR, AUB, CYTH on Behalf of Shareholders

MILAN, Italy (AP) — Atalanta went to the top of Serie A when Ademola Lookman scored with three minutes remaining to beat AC Milan 2-1 on Friday. Atalanta’s ninth win in a row was a fitting gift to coach Gian Piero Gasperini, who was awarded the coach of the month award earlier in the day for guiding his team to a perfect record in November. Charles De Ketelaere put the home side ahead with a towering header after 11 minutes only for Milan to level 11 minutes later. Theo Hernández released Rafael Leão on the right wing and his inviting cross was converted by Álvaro Morata. Milan, which lost Christian Pulišić to a knock before halftime, looked set to end Atalanta’s impressive run but Lookman nipped in at the back post to nod home a corner in the dying moments. Atalanta has 34 points, two more than Napoli, which has a game in hand against Lazio on Sunday. Milan was in seventh place. Serie A champion Inter defeated Parma 3-1 and extended the Milan club’s unbeaten run to 13 games. Federico Dimarco put the home side ahead five minutes before halftime when he worked a neat one-two with Henrikh Mkhitaryan and fired a low shot past Zion Suzuki. Nicolò Barella made it two eight minutes into the second half when he finished a fast counterattack with aplomb. Marcos Thuram's 10th goal of the season made it 3-0 in the 66th. A Matteo Darmian own goal gave some late consolation for Parma. AP soccer: https://apnews.com/hub/soccerOfficers investigating Louise Haigh's "stolen" phone believed a photo she submitted of the handset had been taken after the alleged theft, Sky News has been told. Two sources said after looking at metadata attached to the photo - information that often details when photos were captured - officers believed it had been taken after the date at which Ms Haigh alleged the phone had been stolen. Sources close to Ms Haigh did not respond when approached about the allegation. The Sheffield MP on Friday after Sky News revealed she and was convicted in 2014 in relation to an allegedly stolen phone. The conviction is believed to relate to fraud. The now former transport secretary claims the incident was a "genuine mistake" from which she did not benefit. However, Sky News has spoken to three sources who say the stolen phone report was pursued by Ms Haigh for her own personal gain. Sky News had also spoken to one source who alleged that the handset was used to call Ms Haigh's mother soon after the reported theft, but had been unable to verify the allegation. On Thursday night, Ms Haigh said the incident arose after she was "mugged while on a night out" in 2013. She said she reported the incident to the police and gave officers a list of items she believed had been taken - including a work mobile phone. However, in her statement to Sky News, she said she discovered "some time later" that "the mobile in question had not been taken". In the interim she was issued with another work phone. When she turned on the original work device, it "triggered police attention and I was asked to come in for questioning", she said. "My solicitor advised me not to comment during that interview and I regret following that advice," she added. "Under the advice of my solicitor I pleaded guilty - despite the fact this was a genuine mistake from which I did not make any gain. "The magistrates accepted all of these arguments and gave me the lowest possible outcome (a discharge) available." It is understood Ms Haigh believes she disclosed the incident in full when she was appointed to the shadow cabinet in 2020. However, Downing Street said on Friday that Ms Haigh resigned after "new information" emerged, but declined to say officially if the prime minister knew about the conviction when he appointed his cabinet in July. On Friday, a source told Sky News' political editor Beth Rigby that the story that emerged on Thursday was "inconsistent" with what Sir Keir had been told when Ms Haigh was appointed to his shadow cabinet. It is understood the prime minister was "not able to square the circle" and as a result the cabinet minister was advised to resign. Friends of Ms Haigh insist she shared the "full facts" of the conviction and that Sir Keir "had expressed sympathy that police had taken the decision to prosecute her".