Liudmila Chernetska/iStock via Getty Images Cidara Therapeutics ( NASDAQ: CDTX ) has been making significant progress in developing its drug-FC conjugate [DFC] using its proprietary Cloudbreak technology platform. What makes these molecules ideal is that they are designed to both inhibit proliferation of This article is published by Terry Chrisomalis, who runs the Biotech Analysis Central pharmaceutical service on Seeking Alpha Marketplace. If you like what you read here and would like to subscribe to, I'm currently offering a two-week free trial period for subscribers to take advantage of. My service offers a deep-dive analysis of many pharmaceutical companies. The Biotech Analysis Central SA marketplace is $49 per month, but for those who sign up for the yearly plan will be able to take advantage of a 33.50% discount price of $399 per year. Terry Chrisomalis is a private investor in the Biotech sector with years of experience utilizing his Applied Science background to generate long term value from Healthcare. He is the author of the investing group Biotech Analysis Central which contains a library of 600+ Biotech investing articles, a model portfolio of 10+ small and mid-cap stocks with deep analysis for each, live chat, and a range of analysis and news reports to help Healthcare investors make informed decisions. Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.Currencynewsbreaks Dealflow Events' Upcoming Conference To Showcase Insights, Foster Connections In The Microcap Community
World Bank raises China’s GDP forecast for 2024, 2025Former Green Party leader Caroline Lucas has also resigned as vice-president of the animal welfare organisation, with both of them expressing their “sadness” over leaving the roles. It comes after an Animal Rising investigation made claims of cruelty at “RSPCA Assured” slaughterhouses in England and Scotland, with the campaign group sharing footage of alleged mistreatment. RSPCA Assured is a scheme whereby approved farms must comply with the organisation’s “stringent higher welfare standards”, according to its website. Mr Packham shared the news of his resignation on social media, saying: “It is with enormous sadness that I have resigned from my role as president of the RSPCA. “I would like to register my respect and admiration for all the staff and volunteers who work tirelessly to protect animals from cruelty.” Ms Lucas said she and Mr Packham failed to get the charity’s leadership to act. She posted on X, formerly Twitter: “With huge sadness I’m resigning as VP of the RSPCA, a role I’ve held with pride for over 15 years. “But their Assured Schemes risk misleading the public & legitimising cruelty. “I tried with @ChrisGPackham to persuade the leadership to act but sadly failed.” In June, the RSPCA commissioned an independent review of 200 farms on its assurance scheme which concluded the scheme was “operating effectively” to assure animal welfare on member farms. Following Animal Rising’s release of footage last week, the charity said it was “appalled” by what was shown, adding that it launched an immediate investigation and suspended three slaughterhouses from the scheme. In the wake of Mr Packham and Ms Lucas’ resignations, an RSPCA spokesperson said it is “simply not true” that the organisation has failed to take urgent action. They said: “We agree with Chris and Caroline on so many issues and have achieved so much together for animals, but we differ on how best to address the incredibly complex and difficult issue of farmed animal welfare. “We have discussed our work to drive up farmed animal welfare standards openly at length with them on many occasions and it is simply not true that we have not taken urgent action. “We took allegations of poor welfare incredibly seriously, launching an independent review of 200 farms which concluded that it was ‘operating effectively’ to improve animal welfare. “We are taking strong steps to improve oversight of welfare, implementing the recommendations in full including significantly increasing unannounced visits, and exploring technology such as body-worn cameras and CCTV, supported by £2 million of investment.” The charity insisted that while 94% of people continue to choose to eat meat, fish, eggs and dairy, it is the “right thing to do” to work with farmers to improve the lives of animals. “RSPCA Assured visit all farms on the scheme every year, but last year just 3% of farms were assessed for animal welfare by state bodies,” the spokesperson continued. “No-one else is doing this work. We are the only organisation setting and regularly monitoring animal welfare standards on farms. “We have pioneered change through RSPCA Assured, which has led to improvements throughout the industry including CCTV in slaughterhouses, banning barren battery cages for hens and sow stalls for pigs, giving salmon more space to swim and developing slower growing chicken breeds who have better quality of life.”
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The auto parts aftermarket sector has been battling financial distress over the last year with companies considering strategic alternatives, restructurings, and in some cases filing for bankruptcy. PartsID, which operates an e-commerce auto parts retail business, closed out 2023 by filing for Chapter 11 in December. The company sold auto parts to consumers online through various websites, such as TruckID.com , CardID.com , and CamperID.com . 💸 💰 Don't miss the move: Subscribe to TheStreet's free daily newsletter 💰 💸 Wheel Pros, which operates as auto parts distributor and retailer Hoonigan, filed for a prepackaged Chapter 11 bankruptcy on Sept. 9 to eliminate $1.2 billion in debt and provide about $570 million in new capital through an exit facility. Related: Another major auto parts brand files for Chapter 11 bankruptcy Under a prepackaged bankruptcy, Wheel Pros reached agreements with its equity sponsor Clearlake Capital Group and lenders for a consensual restructuring that would hand 85% of its new equity interests to holders of first-lien claims and the remaining 15% to new first-lien lenders who will backstop the debtor's exit term loan. Another leading manufacturer of wheels and wheel end products for commercial trucks and trailers, Accuride Corp., on Oct. 9 filed for Chapter 11 bankruptcy protection seeking a consensual restructuring of its debt to continue operating as a going concern. Shutterstock Advance Auto Parts closes over 700 stores Finally, giant auto parts retailer Advance Auto Parts revealed that it will close 727 stores and four distribution centers and lay off a significant number of its over 65,000 workers by mid-2025 as part of a strategic turnaround plan. Advance Auto Parts ( AAP ) said it will close 523 corporate-owned stores, exit 204 independent locations, and shut down four West Coast-based distribution centers as part of its asset optimization program, the company said in a Nov. 14 statement reporting its third quarter 2024 results. The Raleigh, N.C.-based auto parts retailer operates 4,781 stores mostly in the U.S., and 1,125 independently-owned Carquest branded stores as of Oct. 5, 2024. Related: Another giant auto parts brand files for Chapter 11 bankruptcy The reduction of company-owned stores amounts to about 10% of its corporate stores, while the elimination of the independent locations amounts to 20% of Advance Auto Parts' non-corporate locations. Under the strategic plan, the company will consolidate its distribution centers to 13 large facilities around the nation by 2026. More auto parts news: The company estimated in its earnings call that it would save about $60 million to $80 million in operating costs related to its store closures, but the elimination of the 727 stores would also reduce its annual net sales by about $700 million. The company did not estimate the amount of layoffs it plans, but it said the reduction in personnel would yield about $50 million in annual savings. The launch of its strategic plan to improve business performance follows the Nov. 1 completion of its sale of auto parts wholesaler and distributor Worldpac for $1.5 billion. "We are pleased to have made progress on our strategic actions, including the completion of the sale of Worldpac and a comprehensive operational productivity review of our business,” CEO Shane O’Kelly said in a statement. “We are charting a clear path forward and introducing a new three-year financial plan, with a focus on executing core retail fundamentals to improve the productivity of all our assets and to create shareholder value." Advance Auto Parts reported a $6 million loss on $2.1 billion in revenue for the third quarter ending Oct. 5, 2024, an improvement compared to a $62 million loss on $2.2 billion in revenue for the same period in 2023. Related: Veteran fund manager sees world of pain coming for stocksRihanna shares why she's proud of ‘baby daddy' A$AP Rocky
After Terry McLaurin weaved his way past five defenders for an 86-yard touchdown catch from Jayden Daniels to cut the Cowboys lead to 27-26 with 21 seconds left, Fox's No. 2 broadcast crew captured the chaos before admonishing the audience not to count on anything as a certainty on this helter-skelter afternoon. "Lightning strikes twice in Washington!" Davis shouted in an homage to Daniels' 52-yard Hail Mary to Noah Brown that stunned the Bears last month. "They dropped 11 guys in coverage," Olsen marveled. "If they just tackle him inbounds the game is over. I don't even know what to say. I'm absolutely speechless." Not for long he wasn't. Olsen quickly cautioned the audience that "Automatic" Austin Siebert had already missed an extra point along with a field goal Sunday in his return from a right hip injury. "Before anyone in Washington gets too fired up, remember, we've seen a missed PAT already," Olsen said. "Yeah, you hold your breath with anything special teams-related on this day," Davis agreed. After all, this was the first game in NFL history to feature two kickoff returns for touchdowns, two errant extra points and a blocked punt. In the 41-point fourth quarter that erased the game's snoozer status, Washington allowed KaVontae Turpin's 99-yard kickoff return for a score. Earlier, the Cowboys missed a field goal and saw another one blocked along with a punt. Sure enough, the snap was low ... the hold was better ... "It is no good!" Davis hollered. "And the worst special teams day in history has a fitting finish!" Actually, no. More ruckus remained. Siebert's onside kick bounced twice in front of safety Juanyeh Thomas, who gathered it in and returned it 43 yards for Dallas' second kickoff return for a touchdown. If Thomas takes a knee short of the goal line, he effectively seals the Cowboys' win. Instead, the score, while pushing Dallas' lead to 34-26, also left enough time for Daniels and the Commanders for a shot at yet another miracle touchdown. Austin Ekeler returned the kickoff to the Washington 36 and after a short gain, Daniels' Hail Mary was intercepted by Israel Mukuamu as time expired. And that's how what Davis called the "worst special teams day in NFL history" came to an end. "What a wild special teams moment of blocked punts, kicks, kickoff returns, blocked field goals," Commanders coach Dan Quinn said. In keeping with the not-so-special-teams theme, there were several foibles in the kicking game across the NFL in Week 12, where the Broncos gave up a 34-yard pass completion on a fake punt that Denver coach Sean Payton swore the team saw coming — and not as it was unfolding, either, but five days earlier. "We met Tuesday as a staff. It wasn't a matter of if, it was when they were going to run a fake punt," Payton said. "You're struggling as a team like this, we had it on the keys to victory, so credit them, they executed it." Thanks to AJ Cole's 34-yard pass to linebacker Divine Deablo that set up a second-quarter field goal, the reeling Raiders took a 13-9 advantage into the locker room, just their second halftime lead of the season. In the second half, the Raiders succumbed to surging rookie QB Bo Nix and veteran wide receiver Courtland Sutton in their 29-19 loss. That's seven straight losses for the Raiders, their longest skid in a decade. The Broncos (7-5), who blew a chance to beat the Chiefs in Week 10 when their 35-yard field goal try was blocked as time ran out, also allowed a 59-yard kickoff return that led to Las Vegas' only touchdown Sunday. The Texans (7-5) lost for the third time in four games after Ka'imi Fairbairn shanked a 28-yard field goal try that would have tied the Titans just after the two-minute warning. Like the Broncos, the Vikings (9-2) overcame a special teams blunder and escaped Soldier Field with a 30-27 overtime win against the Bears after allowing Chicago (4-7) to recover an onside kick with 21 seconds left. Caleb Williams followed with a 27-yard pass to D.J. Moore to set up Cairo Santos' tying 48-yard field goal as the fourth-quarter clock hit zeros.
RSU 9 students utilize iPads in classrooms, tools that Director of Technology Kevin Bremner emphasizes are designed to prepare them for modern workforce demands. The RSU 9 board of directors regularly meet at the Mt. Blue Campus, seen here. File photo/Franklin Journal FARMINGTON — Regional School Unit 9 Director of Technology Kevin Bremner has addressed questions regarding the district’s use of iPads, teacher feedback on Apple Classroom, and efforts to resolve technology challenges in classrooms. Bremner emphasized that the tools provided to students are designed to prepare them for modern workforce demands. Responding to concerns about whether iPads adequately prepare students for “real-world technology” use, Bremner stated, “The idea that iPads aren’t adequately preparing students for ‘real-world technology’ use isn’t accurate.” He highlighted how mobile devices, including iPads, are widely used in industries such as retail, hospitality, technical services and sales. “Business is less about coming to the office and more about bringing your office to them,” Bremner said, explaining how mobile devices are integral to many professions. He added that workers in fields such as engineering, sales estimating, commercial arts, and insurance adjusting often use mobile devices in addition to desktops or laptops. While acknowledging that workers in traditional office settings may use desktops or laptops more frequently, Bremner noted, “The work they do on that will not be different from what they are doing on iPads in school.” He pointed to common tasks such as managing email, word processing and working in proprietary web-based or cloud-based applications, saying, “The form factor may be a little different but the usability experience will be similar.” Bremner reported that teachers have shared “largely positive” feedback about Apple Classroom and Managed Apple IDs. “Depending on the grade level, the app gives the teacher the ability to monitor student work habits [see what’s on their screen]; direct students to specific apps or resources so everyone is working on the same page [this cuts down on wasted time waiting for all students to find their way]; share documents from the teacher to all students at once, instantly, and project a specific student’s iPad to the classroom projector for sharing,” he explained. He also highlighted the convenience of allowing teachers to reset students’ Managed Apple ID passwords when forgotten. On the topic of stylus usage, Bremner confirmed that there are “no plans to expand the use of styluses at this time.” He noted that the district has extra styluses available for teachers to distribute as needed, but compatibility issues with newer iPads have limited their use. “Because of the recent switch from Apple to move from using a lightning port for charging to USB-C port charging for the 10th gen iPad, the charging cables with the iPad models at the elementary level aren’t compatible with the styluses we purchased,” he said. Printing challenges and compatibility with Google apps are being addressed through education and trial-and-error, Bremner explained. “After examining the pros and cons of using the iPadOS app versus the web interface for each of the Google Workspace applications on ease of use and available features, we pushed out the app or webclip based on those discussions so end users are using the most appropriate form without extra effort on their part,” he said. While printing from the web interface presents some challenges, Bremner pointed to an unexpected benefit: “The steps now in place have also created savings in previous wasted printing, which is a significant benefit to RSU 9.” Comments are not available on this story. Send questions/comments to the editors.
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