BLINCYTO® (BLINATUMOMAB) ADDED TO CHEMOTHERAPY SIGNIFICANTLY IMPROVES SURVIVAL IN NEWLY DIAGNOSED PEDIATRIC PATIENTS WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL)Let's be honest, 2024 was a hard year. But even though things didn't always go our way, it doesn't mean we still can't celebrate the accomplishments we finally tackled. So when Reddit user headfullofGHOST asked the r/AskWomenOver30 community: "What's one thing you did this year that you're proud of?" I thought it would be helpful to share their wins (and for you to share your wins in the comments below!). Here are some of their answers: 1. "I ended a toxic relationship that I’ll likely spend years recovering from. I’m only slightly better after nearly a year later." — RebelFemme47 "I also ended a relationship this year (in January) that was going nowhere, and I’m really proud of myself for actually taking the time to be alone and heal. No one talks about how hard it really is to do this. That is probably why a lot of people don’t. I’m praying it’s worth it, though, and next year can be a better year for me. 12 months of these types of feelings hasn’t been easy." — ivegotcharisma 2. "I haven’t had a drink all year." — GrayLightGo 3. "I’ve had driving anxiety my whole life and have been working on it for the past two years. Well, last year, I did a 7-hour road trip to a different state all by myself." — BooBaddy "Congratulations! Seven hours alone in the car is huge!! I have driving anxiety as well. I'm very much not quite where you are yet, but this year, with my boyfriend's help, I started to drive to work about once a week, instead of always taking public transport." — chocolateismynemesis 4. "I got on an airplane for the first time in almost 25 years!" "I took medicine, so that helped a ton — but really, it was completely fine. I brought my laptop and noise-canceling headphones and watched a movie the entire time for both flights, which kept me distracted. I loved the window seat and was actually in awe of seeing the landscape from the sky!" — singtomeepaolo 5. "I bought a house for me and my teen! It felt awesome. I'm a single parent, so going against all the sh%*t people say about us not making it feels awesome. Lol." — TheGrassWasGreener77 6. "I defended my thesis and was awarded distinction. Fucking crushed it. " — rockwrite 7. "I came out to my Chinese family and moved in with my girlfriend (I'm a female). Even when they threatened me with a lot of things, I didn't budge and didn't let it affect me." — watchnoobnoobnoob 8. "I asked for a raise; I’d never done that. I laid out all the ways my work had raised the company’s profits — and I got it!" — MDFUstyle0988 9. "I took an actual vacation with my best friend for the first time in years. We went to Costa Rica to celebrate turning 40 together." — moonshade17 10. "I quit my job of five years in May. It was a toxic environment, and my career was going nowhere. I got an offer at a great company in town, and although it’s been a challenging six months of settling in, I regret nothing." — Lost-Fox-9786 11. "My agoraphobia got bad after COVID, but I've really worked on it this year. It's not perfect; I still chicken out all the time, but I've gotten more accustomed to going to the store on my own, walking into new places by myself, and going out at the last minute without psyching myself up for two days. " — jorgentwo 12. "Started therapy. Best thing!" — LyssQueen "Oh heeyyyyy!! Therapy twin, lol. I also did that this year! I love it when people say they're going to therapy. That's a great thing! It gives you a better perspective on things or how to deal with and unpack. Happy for you!" — headfullofGHOST 13. "Overcoming the cycle of abuse and being the mother I always needed for myself." — JustWordsInYourHead 14. "Finally did my first pull-up! I’m hoping to do three in a row by the end of the year." — tnbunk 15. "Setting boundaries and letting go of unnecessary guilt. I am a recovering people-pleaser and used to feel horrible saying no to things like last-minute invites for family outings when I already had plans. Now, it rolls right off the tongue, 'Hey, thanks! Bummed we can’t be there — but we do have another commitment, and please include us next time!'" — ladyluck754 16. "I let go of some of my hyper-independent tendencies, leaned on friends during some really tough times, and was rewarded leaps and bounds with the knowledge that I’ve got some absolutely solid friends. Also, I somehow tricked my brain into enjoying going to the gym. I feel restless if I don’t go at least twice a week now." — shm4y 17. "Moved to a new country all alone. Not only that, but I made a home here, got to know the city, and even made a few friends. 11 months later, and I feel like I’m settled in." — MPD1987 18. "I joined Big Brothers Big Sisters as a Big and have been hanging out with a Little once a week(ish) since March. I’ve been curious about mentorship for years but have always been afraid that I would not be good enough or that there were too many women who volunteered and they wouldn’t need me. It was a big deal for me to finally just sign up and go through the application process." "And I’m so thankful I finally did it. It’s the single most beneficial thing I’ve done for my mental health and work-life balance this year. It also just feels like a super big responsibility to spend quality time with someone else’s kid and be committed to caring about their life and their potential. We’ve both benefitted enormously from our match." — StrongBad_IsMad 19. "I read 62 books! I'm shooting for 65 before the year ends." — sharonspeaks 20. "I paid off my $26k of credit card debt and started investing my money in the stock market! So far, I have $14k saved, and it’s making money! So cool" "Call Vanguard (it’s free) and speak with a rep to set up a personal investment account. You can use it for savings (totally safe with a current 4.55% interest accrual), and what I’ve been doing now is throwing some money into index funds (VTI & VOO). This will fluctuate with the market, so don’t get scared if you lose money. This is meant to stay in an account for many, many years (it’ll grow, on average, around 10%, with inflation at 7%). In the last month alone, I made $100 on my money just sitting there. Just make sure that whatever money you throw into your portfolio, you commit to leaving it there." — Actual-Employment663 21. "Last year, I finally learned to drive at the age of 33. This year, I drove the first five hours of a nine-hour road trip and the last four hours on the trip back. I was pretty proud of that. Also, I left the house more. Said yes to friends’ invites instead of 'No, thanks' like I always do. Went to four concerts (including the Eras tour ) and several other events instead of just sitting at home 24/7. I’m also learning to keep stuff to myself and stop being nosey when gossiping. Those all sound like 'teenage stuff,' but I’m an extremely late bloomer, and proud of me." — SegoGenesis 22. "Survived. It's been a tough year. Pulling off a transatlantic trip while still being quite deep in depression/grief may come as a close second. I was impressed how I struggled to feed myself on a daily basis but knew exactly how to handle airports and planes." — Valhallan_Queen92 People who identify as women, share with us the one thing you did this year that you're so proud of doing in the comments below. Note: Some responses have been edited for length and/or clarity.None
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San Francisco 49ers quarterback Brock Purdy was limited with the right shoulder injury that sidelined him last week and there is growing concern about the long-term status of left tackle Trent Williams. Wednesday's practice was not the start to the NFL workweek head coach Kyle Shanahan had hoped after Purdy was unable to bounce back from a shoulder injury in Week 11. Brandon Allen started at Green Bay and the 49ers (5-6) lost 38-10 with the backup-turned-starter committing three turnovers. Williams was reportedly spotted in the locker room with a knee scooter and is experiencing pain walking. He played through an ankle injury against the Seattle Seahawks Nov. 17. Defensive end Nick Bosa (hip, oblique) also missed practice Wednesday, leaving the 49ers to spend the holiday plotting to play the Buffalo Bills (9-2) without the three Pro Bowlers again. "I don't know anyone who gets Thanksgiving off unless maybe you have a Monday night game. You just start a lot earlier and get the players out," Shanahan said. "We cram everything in so the players get out, tries to be home with the family by 5. I usually get home by 7 and they're all mad at me, then get back to red-zone (installation)." The 49ers are in danger of a three-game losing streak for the first time since Oct. 2021. Injuries have been a common thread since September when running back Christian McCaffrey was a surprise scratch with an Achilles injury for the opener. Wide receiver Brandon Aiyuk (ACL) is out for the season at a position dinged from top to bottom. Star linebacker Fred Warner also is ailing and said Wednesday that he fractured a bone in his ankle on Sept. 29 against the New England Patriots. The game against the Bills will mark his eighth straight game playing with the injury. "It's something I deal with every game," Warner said. "I get on that table before every game and get it shot up every single game just to be able to roll. But it's not an excuse. It's just what it is. That's the NFL. You're not going to be healthy. You've got to go out there, you've got to find ways to execute, to play at a high level and to win every single week." Shanahan wasn't interested in injury talk. He said the 49ers have not played well in the past two weeks, and puts part of his focus on getting more out of the running game with snow in the forecast on Sunday night. He's not in agreement with pundits who doubt McCaffrey's ability early into his return from injured reserve, with a per-carry average of 3.5 yards compared to 5.4 in 2023. "The speculation on Christian is a little unfair to him," Shanahan said. "Christian is playing very well. He's playing his ass off. To think a guy who misses the entire offseason is going to come back and be the exact same the day he comes back would be unfair to any player in the world." San Francisco opened the 21-day practice window for linebacker Dre Greenlaw, who tore his Achilles in the Super Bowl in February. His return date is unclear. --Field Level Media'Open your doors': Notre Dame re-opens after five-year refit
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Biden says he was ‘stupid’ not to put his name on pandemic relief checks like Trump didNone
Bitcoin has surpassed the $100,000 mark as the post-election rally continues. What's next?When it comes to built-in TV speakers, you’ll be hard-pressed to find a pair of drivers that deliver the volume, clarity, and soundstage that a more robust audio system can provide. We’re talking about soundbars and full surround sound configurations . And while some of these home theater components can cost hundreds (or thousands) of dollars, every once in a while, an amazing discount creeps its way into our crosshairs. As luck would have it, we came across this doorbuster sale when looking through Best Buy deals : Right now, when you purchase the Samsung B Series 2.1ch Soundbar at Best Buy, you’ll only pay $100. At full price, this soundbar once sold for $280. Why you should buy the Samsung B Series 2.1ch Soundbar Plug-and-play connectivity is the name of the game with any soundbar purchase , and the Samsung B Series couldn’t be easier to hook up to your TV. With just one digital optical connection (or Bluetooth TV connection), whatever components are wired to your TV will output sound through the Samsung B Series. Expect bold sound quality with powerful low-end support, too, thanks to the included wireless subwoofer! The Samsung B Series also includes a Bluetooth input, allowing you to stream music and other device audio from a phone, tablet, or PC to your Samsung soundbar. We’re also glad to see a Night Mode for reduced volume when others are trying to sleep, as well as a Voice Enhance feature for louder, more precise dialogue. As a Best Buy doorbuster, there’s a good chance we’ll wake up tomorrow to find the Samsung B Series out of stock, so today is definitely the best day to buy! Take $180 off the Samsung B Series 2.1ch Soundbar when you purchase at Best Buy, and be sure to check out our lists of the best soundbar deals and best Samsung deals for even more discounts.None
AMHERST, Mass. (AP) — Quinton Mincey had 27 points in UMass-Lowell's 96-83 victory over UMass on Saturday. Mincey added six rebounds for the River Hawks (6-4). Martin Somerville scored 22 points and added five assists. Yuri Covington had 19 points and shot 5 of 9 from the field, including 2 for 5 from 3-point range, and went 7 for 8 from the line. Jayden Ndjigue led the way for the Minutemen (3-7) with 17 points, eight rebounds, five assists and two steals. Jaylen Curry added 17 points and two steals for UMass. Marqui Worthy finished with 15 points. UMass-Lowell took a 17-13 lead in the first half with a 10-0 run. Led by 12 first-half points from Covington, UMass-Lowell carried a 40-38 lead into the break. UMass-Lowell took the lead for what would be the final time on Xzavier Lino's jump shot with 15:41 left in the contest. His team would outscore UMass by 11 points in the final half. Story continues below video UMass-Lowell plays Wednesday against LIU at home, and UMass hosts UMass-Boston on Saturday. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
Enstar subsidiary completes deal with James River Group