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2025-01-25
December 24, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Liu Jia, Chinese Academy of Sciences A research team led by Prof. Nie Guangjun from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) and collaborators have demonstrated a tumor membrane antigens-based nanovaccine derived from liposomal doxorubicin treated tumor tissues, which is efficacious in inducing a potent immunological defense against tumors. The study is published online in Cell Reports Medicine . For solid tumor surgeries, challenges remain in postoperative tumor recurrence and metastasis. The correlation between postoperative tumor recurrence and metastasis and the host's antitumor immune status is well-established. Personalized cancer vaccines, using the patient's own tumor as an antigen source, stimulate a robust immune response that is efficacious in eliminating residual neoplastic foci following surgical intervention as well as in targeting metastatic lesions at a distance, significantly reducing the risk of postoperative tumor recurrence and metastasis. The efficacy of autologous tumor cells in clinical trials has been limited by their weak immunogenicity. The tumor membrane contains tumor-presented antigens and associated antigens, which can be developed into a personalized antigen library that more accurately reflects the expression of tumor antigens. Vaccines based on autologous tumor cell membrane antigens have been developed. In clinical practice, patients administered autologous tumor cell membrane-based vaccines (TMVs) frequently have a history of prior therapeutic interventions with chemotherapy being the predominant modality. However, chemotherapy has the potential to alter the immunogenic properties of tumor cell membranes, consequently impacting the therapeutic efficacy of the TMVs. In this study, researchers investigated the effects of preoperative chemotherapy on the efficacy of TMVs employing nano-formulated liposomal doxorubicin (NP-Dox) as a preoperative medication. For the formulation of the TMVs, they obtained the tumor membrane as the antigen, and resiquimod (R848), a potent dual Toll-like receptor 7/8 agonist with excellent efficacy, was encapsulated in Poly (lactide-co-glycolic acid) (PLGA) nanoparticles to act as the adjuvant of the vaccine. The TMVs formulated from liposomal doxorubicin-treated tumors induced superior dendritic cell maturation and T cell activation compared to doxorubicin, demonstrating better efficacy in preventing recurrence and metastasis in the postoperative murine model, as well as in extending postoperative survival. Mechanistically, researchers demonstrated that NP-Dox, as a paradigmatic inducer of immunogenic cell death in tumors, upregulates the expression of immune-related molecules on the tumor cell membrane, enhancing the immunogenicity of tumor membrane antigens. Moreover, they showed that NP-Dox improves the immunological status of the tumor microenvironment, creating favorable conditions for subsequent nanovaccine immunization. "In a previous study, we developed an integrated vaccine formulation based on autologous tumor membrane antigens and bacterial cytoplasmic membrane adjuvants, which could achieve enhanced antitumor immune responses with a favorable biosafety profile," said Assoc. Prof. Zhao Ruifang from NCNST and the first author of this study. "However, for its clinical applications, we found that patients had undergone various treatments before using autologous tumor membrane vaccines with chemotherapy being relatively common." "This study provides valuable insights into the clinical application of TMVs, demonstrating its potential in solid tumor treatments. Concurrently, in this study, we employ nano-drugs both pre-and postoperatively, and showcase the superiority of nanotechnology in the integrated application of neoadjuvant chemotherapy and tumor immunotherapy," said Prof. Nie Guangjun from NCNST and another first author of this study. More information: Yang Chen et al, Neoadjuvant chemotherapy by liposomal doxorubicin boosts immune protection of tumor membrane antigens-based nanovaccine, Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101877 Journal information: Cell Reports Medicine Provided by Chinese Academy of Sciencesjili mk

Tiny council pushing for fibre connectivity for inland residents



Nanovaccine derived from pre-chemotherapy tumors combats multiple tumors in miceAP Trending SummaryBrief at 2:28 p.m. EST

Former Virginia guard Jalen Warley is transferring to Gonzaga, according to several reports Monday. Gonzaga appeared to confirm the transfer by reposting the news on social media. Warley, who has 96 college games (58 starts) under his belt, will use a redshirt this year and spend 2025-26 in Spokane, Wash. Warley played three seasons at Florida State before transferring to Virginia before the 2024-25 season. He was allowed to enter the transfer portal again following the surprise retirement of coach Tony Bennett just three weeks before the season. With the Seminoles, Warley averaged 6.0 points, 2.9 assists, 2.5 rebounds and 1.3 steals per game. His junior year was his best, as he put up 7.5 points, 2.8 assists, 2.6 rebounds and 1.3 steals per game over 33 appearances (32 starts). --Field Level Media

Pennsylvania State Police said remains found 51 years ago in a wooded area of Lebanon County have been identified as 14-year-old Ruth Brenneman, of York County, who disappeared after going to school one day. Two game wardens found her body under a tarp and brush on Oct. 10, 1973. The area where the decomposed body was found — near Fort Indiantown Gap — is about 47 miles from where she lived. Lebanon and York counties are located outside of Harrisburg, Pennsylvania. "Ruth was last seen in the beginning of the 1973 school year after she left for school and never returned home. Ruth Brenneman was a young female just shy of her 15 th birthday and known for her long blonde hair. We continue to investigate the circumstances around Ruth Brenneman’s discovery," Sgt. John Lacey said at a Thursday afternoon news conference. Police did not say how she died or whether her death was a homicide. Investigators said the key to identifying Brenneman was genealogy technology that was gathered using her DNA. Brenneman’s family prepared a statement, which Lacey read at the news conference: "The family wishes to extend our gratitude to Trooper Keck and the others on the Pennsylvania State Police team, who worked diligently to identify Ruthie. Their work has provided us with some closure on questions that have lingered for the past 51 years." Police are asking anyone who knew her or has information about her to contact the Pennsylvania State Police Jonestown station at 717-865-5067. You can also call the PSP tip line at 1-800-472-8477. The tips can be anonymous. Over the years, investigators tried various methods to identify the person they then referred to as "Jane Doe." In 2015, police released a bust that was recreated based on her remains. But no family members or friends came forward. In 2016, investigators exhumed "Jane Doe's" body. "We already have a DNA profile. So one of the ideas is they're going to do an isotope test," Pennsylvania State Police Trooper David Beohm told sister station WGAL at the time. Investigators hoped that the isotope test might tell them where she lived. "Anything at this point is more than what we have," Beohm said. "We'll do whatever we can to find out who this person is."

(NAPSI)—The holidays are the most wonderful time of the year, but when the average American is spending nearly $1,000 on gifts, food, and decorations, they can also be the most stressful. For many, the pressure to create a picture-perfect holiday can stretch budgets a bit too far. Many of today’s shoppers seek advice from their favorite online influencers, sourcing creative hacks, recipes, DIY projects, and tips to keep the holidays magical without overspending. In fact, 69% of consumers say they value and actively seek out influencer recommendations. Now, questions don’t need to get buried in the comments. This December, TextNow is flipping the script on holiday stress by introducing the Holiday Hotline , a free resource to help you navigate the season, with advice a mere text away. Whether it’s finding affordable gifts, creating a festive dinner on a budget, or even learning how to save on your monthly bills, the Holiday Hotline can make things simpler, cheaper, and—perhaps most importantly—more joyful. TextNow Holiday Hotline: Expert Advice at Your Fingertips From December 5–10, TextNow’s Holiday Hotline connects you with relatable experts (aka some of your favorite influencers including social media creator and podcast host Remi Cruz, Kayla Savings, and Melissa Weiss) who will share their go-to tips for a budget-friendly holiday. Here’s what you can expect: • Holiday Budgeting 101: Learn simple ways to stretch every dollar and avoid those dreaded post-holiday bills. • Affordable Gift-Giving Ideas: Thoughtful, creative gifts that won’t break the bank. • Festive Decorating on a Dime: Transform your home into a holiday wonderland with budget-friendly hacks. • Stress-Free Holiday Cooking: Recipes and meal-planning tips to impress your guests. Need more advice? Just text the hotline at 310-299-3584, and you’ll get personalized, practical tips sent straight to your phone. Win $1,000 for Your Holiday Dinner As if free expert advice wasn’t enough, TextNow is also giving you the chance to win big this holiday season. Enter the $1,000 Dinner Giveaway for a shot at a $1,000 gift card to cover your holiday expenses—whether it’s for food, gifts, travel, or whatever else makes your season special. Entering is simple: 1.Head to TextNow’s Instagram . 2.Like the giveaway post. 3.Share your best holiday tip in the comments (bonus: share the post to your story for an extra entry). 4.The giveaway runs from December 5-12, with winners announced from December 13-16. Save More This Holiday Season TextNow is more than just a phone service—it’s a way to take control of your budget, not just during the holidays but year-round. • Free Phone Service: Unlimited calling and texting on the nation’s largest 5G network free. No gimmicks, no contracts. • Free Essential Data: Get free data for such essential apps as maps, rideshare, and email when you activate your SIM card. • Additional Flexible Data Plans: Add extra data only when you need it, with hourly, daily, or monthly passes. Getting started with TextNow is easy. Download the app to call and text for free over Wi-Fi or unlock free cellular service with a $4.99 SIM card. Learn More For more details, visit www.TextNow.com . Word Count: 491WASHINGTON — Federal prosecutors moved Monday to dismiss the criminal charges against President-elect Donald Trump that accused him of plotting to overturn the 2020 election and to abandon the classified documents case against him, citing longstanding Justice Department policy that says sitting presidents cannot face criminal prosecution. The decision by special counsel Jack Smith, who had fiercely sought to hold Trump criminally accountable for his efforts to subvert the 2020 election, represented the end of the federal effort against the former president following his election victory this month despite the election-related cases and multiple other unrelated criminal charges against him and is headed back to the White House. FILE - Special counsel Jack Smith speaks to the media about an indictment of former President Donald Trump, Aug. 1, 2023, at an office of the Department of Justice in Washington. (AP Photo/J. Scott Applewhite, File) The decision, revealed in court filings, also amounts to a predictable but nonetheless stunning conclusion to criminal cases that had been seen as the most perilous of the multiple legal threats Trump has faced. It reflects the practical consequences of Trump’s victory, ensuring he enters office free from scrutiny over his hoarding of top secret documents and his efforts to overturn the 2020 presidential election he lost to Democrat Joe Biden. Smith’s team emphasized that the move to abandon the prosecutions, in federal courts in Washington and Florida, was not a reflection of their view on the merits of the cases but rather a reflection of their commitment to longstanding department policy. “That prohibition is categorical and does not turn on the gravity of the crimes charged, the strength of the Government’s proof, or the merits of the prosecution, which the Government stands fully behind,” the prosecutors wrote in Monday’s court filing in the election interference case. The decision was expected after Smith's team began assessing how to wind down both the 2020 election interference case and the separate classified documents case in the wake of Trump's victory over Vice President Kamala Harris. The Justice Department believes Trump can no longer be tried in accordance with longstanding policy that says sitting presidents cannot be prosecuted. Trump has cast both cases as politically motivated, and had vowed to fire Smith as soon as he takes office in January. President-elect Donald Trump arrives before the launch of the sixth test flight of the SpaceX Starship rocket Tuesday, Nov. 19, 2024 in Boca Chica, Texas. (Brandon Bell/Pool via AP) The 2020 election case brought last year was once seen as one of the most serious legal threats facing the Republican as he vied to reclaim the White House. But it quickly stalled amid legal fighting over Trump’s sweeping claims of immunity from prosecution for acts he took while in the White House. The U.S. Supreme Court in July ruled for the first time that former presidents have broad immunity from prosecution, and sent the case back to U.S. District Judge Tanya Chutkan to determine which allegations in the indictment, if any, could proceed to trial. The case was just beginning to pick up steam again in the trial court in the weeks leading up to this year’s election. Smith’s team in October filed a lengthy brief laying out new evidence they planned to use against him at trial, accusing him of using “resorting to crimes” in an increasingly desperate effort to overturn the will of voters after he lost to Biden. ___ Among President-elect Donald Trump's picks are Susie Wiles for chief of staff, Florida Sen. Marco Rubio for secretary of state, former Democratic House member Tulsi Gabbard for director of national intelligence and Florida Rep. Matt Gaetz for attorney general. Susie Wiles, 67, was a senior adviser to Trump's 2024 presidential campaign and its de facto manager. Trump named Florida Sen. Marco Rubio to be secretary of state, making a former sharp critic his choice to be the new administration's top diplomat. Rubio, 53, is a noted hawk on China, Cuba and Iran, and was a finalist to be Trump's running mate on the Republican ticket last summer. Rubio is the vice chairman of the Senate Intelligence Committee and a member of the Senate Foreign Relations Committee. “He will be a strong Advocate for our Nation, a true friend to our Allies, and a fearless Warrior who will never back down to our adversaries,” Trump said of Rubio in a statement. The announcement punctuates the hard pivot Rubio has made with Trump, whom the senator called a “con man" during his unsuccessful campaign for the 2016 GOP presidential nomination. Their relationship improved dramatically while Trump was in the White House. And as Trump campaigned for the presidency a third time, Rubio cheered his proposals. For instance, Rubio, who more than a decade ago helped craft immigration legislation that included a path to citizenship for people in the U.S. illegally, now supports Trump's plan to use the U.S. military for mass deportations. Pete Hegseth, 44, is a co-host of Fox News Channel’s “Fox & Friends Weekend” and has been a contributor with the network since 2014, where he developed a friendship with Trump, who made regular appearances on the show. Hegseth lacks senior military or national security experience. If confirmed by the Senate, he would inherit the top job during a series of global crises — ranging from Russia’s war in Ukraine and the ongoing attacks in the Middle East by Iranian proxies to the push for a cease-fire between Israel, Hamas and Hezbollah and escalating worries about the growing alliance between Russia and North Korea. Hegseth is also the author of “The War on Warriors: Behind the Betrayal of the Men Who Keep Us Free,” published earlier this year. Trump tapped Pam Bondi, 59, to be attorney general after U.S. Rep. Matt Gaetz withdrew his name from consideration. She was Florida's first female attorney general, serving between 2011 and 2019. She also was on Trump’s legal team during his first impeachment trial in 2020. Considered a loyalist, she served as part of a Trump-allied outside group that helped lay the groundwork for his future administration called the America First Policy Institute. Bondi was among a group of Republicans who showed up to support Trump at his hush money criminal trial in New York that ended in May with a conviction on 34 felony counts. A fierce defender of Trump, she also frequently appears on Fox News and has been a critic of the criminal cases against him. Trump picked South Dakota Gov. Kristi Noem, a well-known conservative who faced sharp criticism for telling a story in her memoir about shooting a rambunctious dog, to lead an agency crucial to the president-elect’s hardline immigration agenda. Noem used her two terms leading a tiny state to vault to a prominent position in Republican politics. South Dakota is usually a political afterthought. But during the COVID-19 pandemic, Noem did not order restrictions that other states had issued and instead declared her state “open for business.” Trump held a fireworks rally at Mount Rushmore in July 2020 in one of the first large gatherings of the pandemic. She takes over a department with a sprawling mission. In addition to key immigration agencies, the Department of Homeland Security oversees natural disaster response, the U.S. Secret Service, and Transportation Security Administration agents who work at airports. The governor of North Dakota, who was once little-known outside his state, Burgum is a former Republican presidential primary contender who endorsed Trump, and spent months traveling to drum up support for him, after dropping out of the race. Burgum was a serious contender to be Trump’s vice presidential choice this summer. The two-term governor was seen as a possible pick because of his executive experience and business savvy. Burgum also has close ties to deep-pocketed energy industry CEOs. Trump made the announcement about Burgum joining his incoming administration while addressing a gala at his Mar-a-Lago club, and said a formal statement would be coming the following day. In comments to reporters before Trump took the stage, Burgum said that, in recent years, the power grid is deteriorating in many parts of the country, which he said could raise national security concerns but also drive up prices enough to increase inflation. “There's just a sense of urgency, and a sense of understanding in the Trump administration,” Burgum said. Robert F. Kennedy Jr. ran for president as a Democrat, than as an independent, and then endorsed Trump . He's the son of Democratic icon Robert Kennedy, who was assassinated during his own presidential campaign. The nomination of Kennedy to lead the Department of Health and Human Services alarmed people who are concerned about his record of spreading unfounded fears about vaccines . For example, he has long advanced the debunked idea that vaccines cause autism. Scott Bessent, 62, is a former George Soros money manager and an advocate for deficit reduction. He's the founder of hedge fund Key Square Capital Management, after having worked on-and-off for Soros Fund Management since 1991. If confirmed by the Senate, he would be the nation’s first openly gay treasury secretary. He told Bloomberg in August that he decided to join Trump’s campaign in part to attack the mounting U.S. national debt. That would include slashing government programs and other spending. “This election cycle is the last chance for the U.S. to grow our way out of this mountain of debt without becoming a sort of European-style socialist democracy,” he said then. Oregon Republican U.S. Rep. Lori Chavez-DeRemer narrowly lost her reelection bid this month, but received strong backing from union members in her district. As a potential labor secretary, she would oversee the Labor Department’s workforce, its budget and put forth priorities that impact workers’ wages, health and safety, ability to unionize, and employer’s rights to fire employers, among other responsibilities. Chavez-DeRemer is one of few House Republicans to endorse the “Protecting the Right to Organize” or PRO Act would allow more workers to conduct organizing campaigns and would add penalties for companies that violate workers’ rights. The act would also weaken “right-to-work” laws that allow employees in more than half the states to avoid participating in or paying dues to unions that represent workers at their places of employment. Scott Turner is a former NFL player and White House aide. He ran the White House Opportunity and Revitalization Council during Trump’s first term in office. Trump, in a statement, credited Turner, the highest-ranking Black person he’s yet selected for his administration, with “helping to lead an Unprecedented Effort that Transformed our Country’s most distressed communities.” Sean Duffy is a former House member from Wisconsin who was one of Trump's most visible defenders on cable news. Duffy served in the House for nearly nine years, sitting on the Financial Services Committee and chairing the subcommittee on insurance and housing. He left Congress in 2019 for a TV career and has been the host of “The Bottom Line” on Fox Business. Before entering politics, Duffy was a reality TV star on MTV, where he met his wife, “Fox and Friends Weekend” co-host Rachel Campos-Duffy. They have nine children. A campaign donor and CEO of Denver-based Liberty Energy, Write is a vocal advocate of oil and gas development, including fracking — a key pillar of Trump’s quest to achieve U.S. “energy dominance” in the global market. Wright also has been one of the industry’s loudest voices against efforts to fight climate change. He said the climate movement around the world is “collapsing under its own weight.” The Energy Department is responsible for advancing energy, environmental and nuclear security of the United States. Wright also won support from influential conservatives, including oil and gas tycoon Harold Hamm. Hamm, executive chairman of Oklahoma-based Continental Resources, a major shale oil company, is a longtime Trump supporter and adviser who played a key role on energy issues in Trump’s first term. President-elect Donald Trump tapped billionaire professional wrestling mogul Linda McMahon to be secretary of the Education Department, tasked with overseeing an agency Trump promised to dismantle. McMahon led the Small Business Administration during Trump’s initial term from 2017 to 2019 and twice ran unsuccessfully as a Republican for the U.S. Senate in Connecticut. She’s seen as a relative unknown in education circles, though she expressed support for charter schools and school choice. She served on the Connecticut Board of Education for a year starting in 2009 and has spent years on the board of trustees for Sacred Heart University in Connecticut. Brooke Rollins, who graduated from Texas A&M University with a degree in agricultural development, is a longtime Trump associate who served as White House domestic policy chief during his first presidency. The 52-year-old is president and CEO of the America First Policy Institute, a group helping to lay the groundwork for a second Trump administration. She previously served as an aide to former Texas Gov. Rick Perry and ran a think tank, the Texas Public Policy Foundation. Trump chose Howard Lutnick, head of brokerage and investment bank Cantor Fitzgerald and a cryptocurrency enthusiast, as his nominee for commerce secretary, a position in which he'd have a key role in carrying out Trump's plans to raise and enforce tariffs. Trump made the announcement Tuesday on his social media platform, Truth Social. Lutnick is a co-chair of Trump’s transition team, along with Linda McMahon, the former wrestling executive who previously led Trump’s Small Business Administration. Both are tasked with putting forward candidates for key roles in the next administration. The nomination would put Lutnick in charge of a sprawling Cabinet agency that is involved in funding new computer chip factories, imposing trade restrictions, releasing economic data and monitoring the weather. It is also a position in which connections to CEOs and the wider business community are crucial. Doug Collins is a former Republican congressman from Georgia who gained recognition for defending Trump during his first impeachment trial, which centered on U.S. assistance for Ukraine. Trump was impeached for urging Ukraine to investigate Joe Biden in 2019 during the Democratic presidential nomination, but he was acquitted by the Senate. Collins has also served in the armed forces himself and is currently a chaplain in the United States Air Force Reserve Command. "We must take care of our brave men and women in uniform, and Doug will be a great advocate for our Active Duty Servicemembers, Veterans, and Military Families to ensure they have the support they need," Trump said in a statement about nominating Collins to lead the Department of Veterans Affairs. Karoline Leavitt, 27, was Trump's campaign press secretary and currently a spokesperson for his transition. She would be the youngest White House press secretary in history. The White House press secretary typically serves as the public face of the administration and historically has held daily briefings for the press corps. Leavitt, a New Hampshire native, was a spokesperson for MAGA Inc., a super PAC supporting Trump, before joining his 2024 campaign. In 2022, she ran for Congress in New Hampshire, winning a 10-way Republican primary before losing to Democratic Rep. Chris Pappas. Leavitt worked in the White House press office during Trump's first term before she became communications director for New York Republican Rep. Elise Stefanik, Trump's choice for U.S. ambassador to the United Nations. Former Hawaii Rep. Tulsi Gabbard has been tapped by Trump to be director of national intelligence, keeping with the trend to stock his Cabinet with loyal personalities rather than veteran professionals in their requisite fields. Gabbard, 43, was a Democratic House member who unsuccessfully sought the party's 2020 presidential nomination before leaving the party in 2022. She endorsed Trump in August and campaigned often with him this fall. “I know Tulsi will bring the fearless spirit that has defined her illustrious career to our Intelligence Community,” Trump said in a statement. Gabbard, who has served in the Army National Guard for more than two decades, deploying to Iraq and Kuwait, would come to the role as somewhat of an outsider compared to her predecessor. The current director, Avril Haines, was confirmed by the Senate in 2021 following several years in a number of top national security and intelligence positions. Trump has picked John Ratcliffe, a former Texas congressman who served as director of national intelligence during his first administration, to be director of the Central Intelligence Agency in his next. Ratcliffe was director of national intelligence during the final year and a half of Trump's first term, leading the U.S. government's spy agencies during the coronavirus pandemic. “I look forward to John being the first person ever to serve in both of our Nation's highest Intelligence positions,” Trump said in a statement, calling him a “fearless fighter for the Constitutional Rights of all Americans” who would ensure “the Highest Levels of National Security, and PEACE THROUGH STRENGTH.” Trump has chosen former New York Rep. Lee Zeldin to serve as his pick to lead the Environmental Protection Agency . Zeldin does not appear to have any experience in environmental issues, but is a longtime supporter of the former president. The 44-year-old former U.S. House member from New York wrote on X , “We will restore US energy dominance, revitalize our auto industry to bring back American jobs, and make the US the global leader of AI.” “We will do so while protecting access to clean air and water,” he added. During his campaign, Trump often attacked the Biden administration's promotion of electric vehicles, and incorrectly referring to a tax credit for EV purchases as a government mandate. Trump also often told his audiences during the campaign his administration would “Drill, baby, drill,” referring to his support for expanded petroleum exploration. In a statement, Trump said Zeldin “will ensure fair and swift deregulatory decisions that will be enacted in a way to unleash the power of American businesses, while at the same time maintaining the highest environmental standards, including the cleanest air and water on the planet.” Trump has named Brendan Carr, the senior Republican on the Federal Communications Commission, as the new chairman of the agency tasked with regulating broadcasting, telecommunications and broadband. Carr is a longtime member of the commission and served previously as the FCC’s general counsel. He has been unanimously confirmed by the Senate three times and was nominated by both Trump and President Joe Biden to the commission. Carr made past appearances on “Fox News Channel," including when he decried Democratic Vice President Kamala Harris' pre-Election Day appearance on “Saturday Night Live.” He wrote an op-ed last month defending a satellite company owned by Trump supporter Elon Musk. Rep. Elise Stefanik is a representative from New York and one of Trump's staunchest defenders going back to his first impeachment. Elected to the House in 2014, Stefanik was selected by her GOP House colleagues as House Republican Conference chair in 2021, when former Wyoming Rep. Liz Cheney was removed from the post after publicly criticizing Trump for falsely claiming he won the 2020 election. Stefanik, 40, has served in that role ever since as the third-ranking member of House leadership. Stefanik’s questioning of university presidents over antisemitism on their campuses helped lead to two of those presidents resigning, further raising her national profile. If confirmed, she would represent American interests at the U.N. as Trump vows to end the war waged by Russia against Ukraine begun in 2022. He has also called for peace as Israel continues its offensive against Hamas in Gaza and its invasion of Lebanon to target Hezbollah. President-elect Donald Trump says he's chosen former acting Attorney General Matt Whitaker to serve as U.S. ambassador to NATO. Trump has expressed skepticism about the Western military alliance for years. Trump said in a statement Wednesday that Whitaker is “a strong warrior and loyal Patriot” who “will ensure the United States’ interests are advanced and defended” and “strengthen relationships with our NATO Allies, and stand firm in the face of threats to Peace and Stability.” The choice of Whitaker as the nation’s representative to the North Atlantic Treaty Organization is an unusual one, given his background is as a lawyer and not in foreign policy. Trump will nominate former Arkansas Gov. Mike Huckabee to be ambassador to Israel. Huckabee is a staunch defender of Israel and his intended nomination comes as Trump has promised to align U.S. foreign policy more closely with Israel's interests as it wages wars against the Iran-backed Hamas and Hezbollah. “He loves Israel, and likewise the people of Israel love him,” Trump said in a statement. “Mike will work tirelessly to bring about peace in the Middle East.” Huckabee, who ran unsuccessfully for the Republican presidential nomination in 2008 and 2016, has been a popular figure among evangelical Christian conservatives, many of whom support Israel due to Old Testament writings that Jews are God’s chosen people and that Israel is their rightful homeland. Trump has been praised by some in this important Republican voting bloc for moving the U.S. embassy in Israel from Tel Aviv to Jerusalem. Trump on Tuesday named real estate investor Steven Witkoff to be special envoy to the Middle East. The 67-year-old Witkoff is the president-elect's golf partner and was golfing with him at Trump's club in West Palm Beach, Florida, on Sept. 15, when the former president was the target of a second attempted assassination. Witkoff “is a Highly Respected Leader in Business and Philanthropy,” Trump said of Witkoff in a statement. “Steve will be an unrelenting Voice for PEACE, and make us all proud." Trump also named Witkoff co-chair, with former Georgia Sen. Kelly Loeffler, of his inaugural committee. Trump asked Rep. Michael Waltz, R-Fla., a retired Army National Guard officer and war veteran, to be his national security adviser, Trump announced in a statement Tuesday. The move puts Waltz in the middle of national security crises, ranging from efforts to provide weapons to Ukraine and worries about the growing alliance between Russia and North Korea to the persistent attacks in the Middle East by Iran proxies and the push for a cease-fire between Israel and Hamas and Hezbollah. “Mike has been a strong champion of my America First Foreign Policy agenda,” Trump's statement said, "and will be a tremendous champion of our pursuit of Peace through Strength!” Waltz is a three-term GOP congressman from east-central Florida. He served multiple tours in Afghanistan and also worked in the Pentagon as a policy adviser when Donald Rumsfeld and Robert Gates were defense chiefs. He is considered hawkish on China, and called for a U.S. boycott of the 2022 Winter Olympics in Beijing due to its involvement in the origin of COVID-19 and its mistreatment of the minority Muslim Uighur population. Stephen Miller, an immigration hardliner , was a vocal spokesperson during the presidential campaign for Trump's priority of mass deportations. The 39-year-old was a senior adviser during Trump's first administration. Miller has been a central figure in some of Trump's policy decisions, notably his move to separate thousands of immigrant families. Trump argued throughout the campaign that the nation's economic, national security and social priorities could be met by deporting people who are in the United States illegally. Since Trump left office in 2021, Miller has served as the president of America First Legal, an organization made up of former Trump advisers aimed at challenging the Biden administration, media companies, universities and others over issues such as free speech and national security. Thomas Homan, 62, has been tasked with Trump’s top priority of carrying out the largest deportation operation in the nation’s history. Homan, who served under Trump in his first administration leading U.S. Immigration and Customs Enforcement, was widely expected to be offered a position related to the border, an issue Trump made central to his campaign. Though Homan has insisted such a massive undertaking would be humane, he has long been a loyal supporter of Trump's policy proposals, suggesting at a July conference in Washington that he would be willing to "run the biggest deportation operation this country’s ever seen.” Democrats have criticized Homan for his defending Trump's “zero tolerance” policy on border crossings during his first administration, which led to the separation of thousands of parents and children seeking asylum at the border. Dr. Mehmet Oz, 64, is a former heart surgeon who hosted “The Dr. Oz Show,” a long-running daytime television talk show. He ran unsuccessfully for the U.S. Senate as the Republican nominee in 2022 and is an outspoken supporter of Trump, who endorsed Oz's bid for elected office. Elon Musk, left, and Vivek Ramaswamy speak before Republican presidential nominee former President Donald Trump at an Oct. 27 campaign rally at Madison Square Garden in New York. Trump on Tuesday said Musk and former Republican presidential candidate Ramaswamy will lead a new “Department of Government Efficiency" — which is not, despite the name, a government agency. The acronym “DOGE” is a nod to Musk's favorite cryptocurrency, dogecoin. Trump said Musk and Ramaswamy will work from outside the government to offer the White House “advice and guidance” and will partner with the Office of Management and Budget to “drive large scale structural reform, and create an entrepreneurial approach to Government never seen before.” He added the move would shock government systems. It's not clear how the organization will operate. Musk, owner of X and CEO of Tesla and SpaceX, has been a constant presence at Mar-a-Lago since Trump won the presidential election. Ramaswamy suspended his campaign in January and threw his support behind Trump. Trump said the two will “pave the way for my Administration to dismantle Government Bureaucracy, slash excess regulations, cut wasteful expenditures, and restructure Federal Agencies.” Russell Vought held the position during Trump’s first presidency. After Trump’s initial term ended, Vought founded the Center for Renewing America, a think tank that describes its mission as “renew a consensus of America as a nation under God.” Vought was closely involved with Project 2025, a conservative blueprint for Trump’s second term that he tried to distance himself from during the campaign. Vought has also previously worked as the executive and budget director for the Republican Study Committee, a caucus for conservative House Republicans. He also worked at Heritage Action, the political group tied to The Heritage Foundation, a conservative think tank. Scavino, whom Trump's transition referred to in a statement as one of “Trump's longest serving and most trusted aides,” was a senior adviser to Trump's 2024 campaign, as well as his 2016 and 2020 campaigns. He will be deputy chief of staff and assistant to the president. Scavino had run Trump's social media profile in the White House during his first administration. He was also held in contempt of Congress in 2022 after a month-long refusal to comply with a subpoena from the House committee’s investigation into the Jan. 6, 2021, attack on the U.S. Capitol. Blair was political director for Trump's 2024 campaign and for the Republican National Committee. He will be deputy chief of staff for legislative, political and public affairs and assistant to the president. Blair was key to Trump's economic messaging during his winning White House comeback campaign this year, a driving force behind the candidate's “Trump can fix it” slogan and his query to audiences this fall if they were better off than four years ago. Budowich is a veteran Trump campaign aide who launched and directed Make America Great Again, Inc., a super PAC that supported Trump's 2024 campaign. He will be deputy chief of staff for communications and personnel and assistant to the president. Budowich also had served as a spokesman for Trump after his presidency. McGinley was White House Cabinet secretary during Trump's first administration, and was outside legal counsel for the Republican National Committee's election integrity effort during the 2024 campaign. In a statement, Trump called McGinley “a smart and tenacious lawyer who will help me advance our America First agenda, while fighting for election integrity and against the weaponization of law enforcement.” Associated Press writer Colleen Long contributed to this story. We're always interested in hearing about news in our community. Let us know what's going on! Stay up-to-date on the latest in local and national government and political topics with our newsletter.Trump’s unusual labor secretary pick — Oregon’s Chavez-DeRemer — could have an impact at homeTo improve your local-language experience, sometimes we employ an auto-translation plugin. Please note auto-translation may not be accurate, so read article for precise information. The ongoing bull cycle has seen many cryptos breaking through year-long bottlenecks. Dogecoin and Cardano are two of the star performers, with the former running over 250% to peak at $0.45 and the latter surging above the $2.78 mark for the first time since 2018. Experts expect them to see more gains soon. Despite these incredible performances, Rexas Finance (RXS), a new crypto in the real-world asset tokenization sector, is generating buzz for its incredible presale and ongoing $1 million giveaway. Analysts laud it as the next big thing in the crypto market. Rexas Finance’s RWA tokenization ecosystem redefines financial decentralization. The project effortlessly tokenizes physical and digital assets using blockchain technology, democratizing investment and increasing liquidity in traditionally non-liquid sectors, including real estate, commodities, and art. Rexas Finance’s key feature is a simple Token Builder that allows users to create digital tokens and NFTs without coding. When used with the QuickMint Bot, users may rapidly manufacture and distribute tokens via platforms like Telegram and Discord. This unique feature decreases technological hurdles, allowing corporations, creators, and community projects to participate more broadly. Rexas Treasury strengthens the ecosystem by automating yield farming and compounding interest across several chains, guaranteeing that investors receive the highest possible returns. The most recent Certik audit gives Rexas Finance another degree of reputation. Certik’s thorough inspection process guarantees the platform’s security, gaining investors’ trust and ensuring a strong ecosystem free of weaknesses. Lists on CoinMarketCap and CoinGecko support the project’s validity and increase its reach, drawing more traders and generating liquidity. Rexas Finance has also gained traction with its presale success. In Stage 10, the presale has raised an impressive $30.2 million, with 360 million RXS tokens sold. RXS is currently priced at $0.15, with a raise to $0.175 expected for Stage 11. After the presale is completed, the cryptocurrency will list on three Tier-1 exchanges for $0.20, a notable price shift that can provide early investors with large returns. Rexas Finance is running a $1 million giveaway with 20 winners scheduled to get $50,000 worth of RXS tokens apiece, fueling interest even further. Apart from benefiting the community, this project generates buzz that stimulates more engagement prior to its anticipated mega-listings. Rexas Finance has excellent market potential. Experts believe the RWA tokenization sector will reach $50 billion next year, offering early projects like Rexas Finance the leadership status. Driven by strong foundations and bullish market moods, Dogecoin and XRP still exhibit profitability. DOGE has seen significant whale accumulation. Over 60.9 billion DOGE was traded in 24 hours, increasing investor confidence. Currently consolidating around $0.40, analysts estimate a 400% increase by early 2025, which might drive its price to $2, in line with past trends that have preceded significant rallies. Key reasons for DOGE’s possible breakout include its relationship with Elon Musk and its growing acceptance as a payment method. XRP rallied around 500% between mid-November and early December to set a cycle peak of $2.71 before consolidating between $2.25 and $2.46. Analysts—including CrediBULL Crypto—have a favorable view; XRP is anticipated to reach $22 by early 2025. Such an action would show a 784% increase, raising the market cap to $1.26 trillion. The release of Ripple’s RLUSD stablecoin gives XRP’s ecosystem even more value by increasing adoption and improving its long-term future. Despite short-term consolidation, DOGE and XRP have robust technical structures. DOGE’s RSI is near 45, indicating neutral momentum and potential for upward growth, while XRP’s higher time frame structure predicts consolidation before another significant breakout. The general bullish sentiment in the crypto sector and Bitcoin’s recent all-time highs support higher trajectories for both assets. While Dogecoin and Ripple remain solid investments with significant upside potential, Rexas Finance is emerging as the clear standout. With its presale success, creative ecosystem, and strategic developments, RXS is well-positioned to capitalize on the vast prospects in DeFi and asset tokenization. Investors seeking the next big breakthrough should closely monitor Rexas Finance as it concludes its presale and gears up for Tier-1 exchange listings. RXS and its burgeoning ecosystem have an unquestionably bright future ahead. In line with the , please note that the information provided on this page is not intended to be and should not be interpreted as legal, tax, investment, financial, or any other form of advice. It is important to only invest what you can afford to lose and to seek independent financial advice if you have any doubts. For further information, we suggest referring to the terms and conditions as well as the help and support pages provided by the issuer or advertiser. MetaversePost is committed to accurate, unbiased reporting, but market conditions are subject to change without notice. Gregory, a digital nomad hailing from Poland, is not only a financial analyst but also a valuable contributor to various online magazines. With a wealth of experience in the financial industry, his insights and expertise have earned him recognition in numerous publications. Utilising his spare time effectively, Gregory is currently dedicated to writing a book about cryptocurrency and blockchain. Gregory, a digital nomad hailing from Poland, is not only a financial analyst but also a valuable contributor to various online magazines. With a wealth of experience in the financial industry, his insights and expertise have earned him recognition in numerous publications. Utilising his spare time effectively, Gregory is currently dedicated to writing a book about cryptocurrency and blockchain.

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DeSantis, Trump Mend Fences After Florida Cannabis Split While Pete Hegseth Scandal Deepens

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