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December 14, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Columbia University Since 2006, Ruben Gonzalez's Columbia lab has used single-molecule light microscopy to study the structural dynamics of biomolecules. In lay person's terms, that means: they use hyper-powerful microscopes that generate movies of what individual molecules look like as they perform the actions that make our bodies tick. Gonzalez is a professor of biophysical chemistry in Columbia's Faculty of Arts and Sciences and at the Columbia University Irving Medical Center, and will become Dean of Science in the Faculty of Arts and Sciences in January. In a new paper out this month in the journal Nature , he and his lab describe a major new finding about how the eIF4F protein interacts with messenger RNAs. Columbia News spoke with Gonzalez about his research, and how his latest finding could affect drug treatments for diseases like cancer. Can you explain your lab's work broadly? My lab is interested in trying to understand how the motions of biomolecules—molecules produced by the body—contribute to their functions. We record movies to give us a data-informed sense of what those motions look like. That allows us to understand how the biology really functions, which in turn can help us and other scientists think about how we might control that biology by manipulating such motions, providing a new paradigm for developing therapies to tackle diseases like cancer. There are many cases where drugs act by impairing a biomolecular motion, so understanding that motion is crucial. The dream is to be able to record these movies at atomic scales and in real-time. But we're not there yet. What led you to record these movies? For a long time, static images of biomolecules at atomic scales exhibited blurry regions, which led scientists to the conclusion that parts of the biomolecule were moving, and that such motions might be important to biology. It sort of captured my imagination. What are the moving parts, and where are they moving? What is the timing of these motions, and why is all of this important? Those kinds of questions have really been the driving feature of all we do in the lab. We do a lot of technology development in my lab. We build these microscopes, we optimize them, we continuously push the technology. We also have a whole group that develops computational algorithms and software for the analysis of the data that comes from these. What does the new paper in Nature show? To make proteins, which are the building blocks of everything in our cells and in our bodies, cells need to prepare messenger RNAs (mRNAs), the molecules that carry the building instructions. They do that with the help of a protein called eukaryotic initiation factor 4F, or eIF4F, that must converge at a certain location at one end of the mRNA, which we call the mRNA "cap." Using our movie technology and led by graduate students Riley Gentry and Nicholas Ide, we discovered—quite unexpectedly—that eIF4F doesn't just directly assemble at the cap as everyone had always assumed. Instead, it 'hops' along the mRNA trying to identify the cap. One reason this is important is that drugs, such as anticancer drugs , that aim to disrupt this process in order to stop dangerous cells like cancer cells from proliferating currently target the direct assembly of eIF4F at the cap. Our finding provides a deeper understanding of how eIF4F actually finds its way to the cap on the mRNA, which will help us develop more targeted therapies for cancer and other diseases. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . What makes the finding significant? There are a number of things that make this a significant finding. It's really redefining something fundamental about this critical biological function, in a way that will rewrite what's in textbooks. It also answers some big, decades-old questions that we and others have had, which is that we've known for decades that different regions and properties of the mRNA that are far away from the cap can influence the ability of eIF4F to converge at the cap, but no one has ever been able to figure out how that could be, and our findings help explain this. Another reason is that if you can develop drugs that influence the search that eIF4F does along the mRNA, it could have big implications. It could help us more precisely target particular mRNAs, manipulating the production of the specific proteins at the heart of the disease. That could mean that future cancer drugs would use something more like a scalpel than a sledgehammer to stop molecular motions that have gone awry, rather than halting a whole bunch of processes that include the dangerous ones you want to stop but also good ones you would want to leave unimpaired. More information: Riley C. Gentry et al, The mechanism of mRNA cap recognition, Nature (2024). DOI: 10.1038/s41586-024-08304-0 Journal information: Nature Provided by Columbia UniversityStalled engines? Driverless routes and roboshuttlesCalgary Stampeders sign Paredes to extension, restructure Adams's contract
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Samsung announced the launch of a new exclusive channel for . The company is expanding its premium FAST entertainment platform with the addition of . The new channel goes live today in the USA and Canada. Letterman TV is a 24/7 channel that streams Late Show with David Letterman, curated moments, and even never-before-seen commentary from the late-night talk show host. Walter Kim, Executive Producer for Digital at Letterman's production company, said, David Letterman jokingly added, The exclusive Letterman TV 24/7 channel will tap into a vast library large enough to fit more than 4,000 hours of content, so the channel will continuously change. New content will be added to Letterman TV on Samsung TV Plus every month. Initially, the channel's offering includes Julia Roberts and Tom Hanks playing , Denzel Washington with Don Rickles and Dave, musical performances by Ringo Starr, Will Farrell's comedy skits, and more. said Samsung TV Plus Senior Vice President & General Manager Salek Brodsky to mark the launch of the new exclusive channel. Samsung's FAST (free ad-supported streaming TV) platform is available in the USA and Canada across smart TVs and Smart Monitors, Family Hub, and Galaxy devices. The latest Samsung smart TVs, released in 2024, take advantage of new AI upscaling technologies to deliver crisp 4K and 8K quality content. If you're in the market for a TV, Samsung has plenty of discounts for the shopping season. And if you are looking for guidance on which Samsung smart TV you should buy, we recommend checking out , where we recently published a handful of reviews on Samsung TVs at different price points, including Neo QLED and OLED models.
Maryland Gov. Wes Moore and Baltimore Mayor Brandon Scott hope a newly planned weeks-long festival will draw more fans, and revenue, to the Preakness Stakes and the area as the city prepares to host the second jewel of the Triple Crown. The biggest event on Baltimore’s spring calendar has lost money in recent years. Crowds have dwindled from an average of more than 100,000 in the decade before the coronavirus pandemic to 63,423 on Friday and Saturday last May. Young people have turned away from thoroughbred racing and the signature event, despite the presence of headlining musical acts such as Bruno Mars in 2023 and Jack Harlow in 2024 . Moore and Scott hope to turn the tide leading up to the 150th running of the race on May 17 — the final turn around the current version of the soon-to-be renovated Pimlico Race Course. “Preakness is a chance for Baltimore to show off,” Moore said at a presentation Wednesday on the sixth floor of the warehouse at Camden Yards. “And that’s what’s going to happen with Preakness 150.” Shortly after next year’s race, bulldozers and wrecking balls will begin demolishing the dilapidated facility as part of a $400 million rebuild expected to have a new Pimlico ready to host the Preakness by 2027. The refurbished track, in tandem with a new off-site training facility, is expected to become the headquarters for Maryland thoroughbred racing by the end of that year. Wednesday’s presentation was short on specifics, with festival organizers saying only that the buildup to the Preakness will last for months and that a list of events — including free and ticketed cultural gatherings, arts activities, and a headline concert — will be released in early 2025. But the co-chairs of the initiative are heavy hitters, from the first lady Dawn Moore to Orioles owner David Rubenstein to Stronach Group CEO Belinda Stronach, whose Canadian company still owns the Preakness despite having sold Pimlico to the state earlier this year. They said its events will “deliver experiences that equitably enhance economic growth, promote tourism and inspire civic pride through collaborative work with small-, minority-, women- and veteran-owned businesses.” Dawn Moore said the seed of the idea hit her after she and her husband visited the Kentucky Derby two years ago and recognized that the parties and community events leading up to the first jewel of the Triple Crown take over Louisville for weeks leading up to the actual race. Dec 11, 2024: Baltimore City Mayor Brandon Scott speaks at a media event at the Warehouse at Camden Yards previewing plans for the 150th running of the Preakness Stakes, a Preakness Festival and future plans for Pimlico Race Course and the Park Heights community. Listening are Maryland First Lady Dawn Moore, Governor Wes Moore and David Rubenstein, owner of the Baltimore Orioles. (Kim Hairston/Staff) Maryland First Lady Dawn Moore speaks at a press event to preview plans for the 150th running of the Preakness Stakes. A Preakness Festival, future plans for Pimlico Race Course and the Park Heights community were highlighted at the event held at the Warehouse at Camden Yards. (Kim Hairston/Staff) Maryland First Lady Dawn Moore speaks at a press event to preview plans for the 150th running of the Preakness Stakes. A Preakness Festival, future plans for Pimlico Race Course and the Park Heights community were highlighted at the event held at the Warehouse at Camden Yards. (Kim Hairston/Staff) Baltimore Mayor Brandon Scott helped announce the creation of a new weeks-long festival designed to draw more attention to the Preakness Stakes. (Kim Hairston/Staff) Maryland Governor Wes Moore speaks at a press event about plans for the 150th running of the Preakness Stakes including a Preakness Festival, future plans for Pimlico Race Course and the Park Heights community. (Kim Hairston/Staff) From left, Terry Hasseltine, executive director of the Maryland Sports Commission and president of Sports and Entertainment Corporation of Maryland, Governor Wes Moore, First Lady Dawn Moore and David Rubenstein, owner of the Baltimore Orioles, watch a video promoting the Preakness Festival for the 150th running of the Preakness Stakes. The press event is held at the Warehouse at Camden Yards. (Kim Hairston/Staff) Maryland Governor Wes Moore speaks at a press event about plans for the 150th running of the Preakness Stakes including a Preakness Festival, future plans for Pimlico Race Course and the Park Heights community. (Kim Hairston/Staff) Terry Hasseltine, executive director of the Maryland Sports Commission and president of Sports and Entertainment Corporation of Maryland speaks about plans for the 150th running of the Preakness Stakes during a press event at the Warehouse at Camden Yards. (Kim Hairston/Staff) Dec 11, 2024: Baltimore City Mayor Brandon Scott speaks at a media event at the Warehouse at Camden Yards previewing plans for the 150th running of the Preakness Stakes, a Preakness Festival and future plans for Pimlico Race Course and the Park Heights community. Listening are Maryland First Lady Dawn Moore, Governor Wes Moore and David Rubenstein, owner of the Baltimore Orioles. (Kim Hairston/Staff) “We could do it better,” she recalled telling the governor. “Well, go do it then,” she remembered him responding. One of the festival’s other co-chairs, Stella May Contracting chief financial officer Christian Johansson, noted that the Derby generated $396 million in economic impact for Kentucky in 2023 while the most recent study on the Preakness showed it generated just $41 million for Maryland. “The main reason is the Derby isn’t one or two days,” Johansson said. “Maryland historically has not fully captured the economic impact the Preakness could have.” Rubenstein donated to supplement funds from the Maryland Lottery’s major events fund to help get the new festival off the ground. The Orioles owner said he was dining with the Moores when the first lady ran the play by him. “That’s a pretty clever idea,” Rubenstein recalled thinking. “How come nobody else thought of that before?” He noted that he grew up a mile from Pimlico but never visited the track as a child because he wasn’t old enough. He promised to be there to celebrate the winner in 2025. Scott grew up even closer, in Park Heights, but recalled not feeling welcome at the Preakness, which he did not attend until 2019. He said that this new initiative is about forging deeper connections between the event and the community around it. He and Moore noted that the Pimlico rebuild project includes $10 million for affordable housing and job creation in surrounding neighborhoods and that the festival will play off that mission. “We want to show the world the real and true Baltimore,” the mayor said. “One that is resilient, fun and on the rise, one that is the home of excellence but in particular, this Old Bay-sprinkled Black excellence. “That’s not what Preakness has always been. It hasn’t always been a place where we felt welcome. It was held in Northwest Baltimore, but it was very clear that it wasn’t for Northwest Baltimore. But over the past few years ... we’ve begun to change that narrative.” Have a news tip? Contact Childs Walker at daviwalker@baltsun.com , 410-332-6893 and x.com/ChildsWalker .
Netizens say THIS man has been blessed by Hanuman Ji, and here's the shocking reason whyThe Vancouver Canucks got some coal in their stocking over the holiday break. Two of the team's biggest stars, Quinn Hughes and Elias Pettersson, were missing from Friday's practice and, according to head coach Rick Tocchet, will not play in Saturday afternoon's game against the Seattle Kraken. While the full scope of their injuries isn't yet known, with Tocchet saying he wasn't sure if they were day-to-day or week-to-week, but they want to play it safe. "Especially with a guy like Hughes, I don't think you want to put him in situations where he could really get hurt," said Tocchet. "I don't think you want to do that with any player. You've got to be careful of that." You definitely want to be careful to avoid turning a short-term injury into a long-term injury but it's hard to take Tocchet entirely seriously when he says the team wants to avoid putting players institutions where they could really get hurt because they already have. Hughes was questionable for December 23's game against the Sharks — a game-time decision. He not only played but also led the Canucks in ice time with 24:45. After the game, Hughes admitted that he needed the holiday break. "I think that the break's coming at a fortunate time," said Hughes. "I've got three days here just to recover and regroup and we'll see what's going on after that." If whatever injury he's dealing with is significant enough for him to miss Saturday's game perhaps it was serious enough that he should have missed the game against the Sharks as well. Was that not Hughes being in a position to get "really hurt?" Tocchet even praised Hughes for playing through his injury. "Obviously, our captain, dealing with some stuff, to play and get two points for us, I'm really proud of him," said Tocchet after the game. "He sucked it up tonight." As for Pettersson, he got “banged up” in the second period of that game against the Sharks according to Tocchet but then came back for the third period and played a shift before finally leaving the game. Should he have returned to the game? Did the medical staff miss something? Was that not a situation where he could have been further injured? Here’s the thing: I don’t even blame Tocchet or the Canucks’ medical staff for Hughes and Pettersson playing through injuries. Often, they can only go off what the players self-report in terms of how their body is feeling and how much pain is too much. Fundamentally, hockey players want to play and they'll push themselves through all sorts of pain to do it. For Pettersson in particular, he might not have even known the extent of what he was dealing with until he took the ice for the third period and pushed himself. It’s also part and parcel of hockey culture that players play through pain and injury. In fact, most players in the NHL are playing through something, whether it’s minor bumps and bruises that are merely uncomfortable or long-term issues that can’t really be fixed but can be managed. In all honesty, every time a player steps on the ice, they’re entering a situation where they could get "really hurt." That's a fundamental risk of a fast, physical sport like hockey. Playing through pain isn't unique to hockey either. All sports lionize athletes who grit their teeth and bear through the pain to accomplish something great. But you do have to wonder if playing through pain and injuries is really worth it in late December. It’s one thing to battle through pain in the playoffs in the quest for the Stanley Cup when every game is of the utmost importance; it’s quite another to risk causing a bigger issue for one of 82 games in the regular season. Perhaps it would have been wiser for Hughes to sit out against the Sharks to get a bit more rest for whatever injury is bothering him. Maybe Pettersson shouldn’t have pushed it by returning for the third period. And if the Canucks couldn’t beat the basement-dwelling Sharks without Hughes, maybe that says a lot about how the team is currently constructed. Without Hughes and Pettersson at practice on Friday, the Canucks had to shake up the forward lines and defence pairings. Here are the Canucks' projected lines: Just as Pettersson had to step up when J.T. Miller stepped away from the team for personal reasons, Miller will have to step up in Pettersson's absence. He'll centre the Canucks' two best wingers in Jake DeBrusk and Brock Boeser. Pius Suter filled in admirably as a second-line centre when Miller was gone, so he'll be back on the second line with Nils Höglander and Conor Garland, with hopes of creating some secondary offence behind Miller. The one forward line that remains intact is the fourth line — now third line — of Danton Heinen, Teddy Blueger, and Kiefer Sherwood. Finally, Max Sasson returns to the lineup, this time at centre between Dakota Joshua and Phil Di Giuseppe. The bigger question, of course, is how the Canucks will handle being without Hughes, especially with Filip Hronek already out long-term. At practice, the top pairing consisted of Derek Forbort and Tyler Myers, which is sobering. Erik Brännström will draw back into the lineup alongside Vincent Desharnais. Brännström will also quarterback the top power play unit and could play some bigger minutes as the only true puck-mover on the Canucks' blue line with Hughes out. The Canucks' starting goaltender will be Thatcher Demko. He has an .889 save percentage in five starts since returning from his popliteus injury but has helped the Canucks earn at least a point in four of those five starts with a 2-1-2 record. The Seattle Kraken are struggling this season, sitting just barely above the Anaheim Ducks in the Pacific Division with a 15-19-2 record. They lost five straight heading into the holiday break. Don't be surprised, then, if the Kraken shake up their lines and try something different against the Canucks on Saturday. Until they show us anything different, however, these are the projected lines: Jaden Schwartz - Matty Beniers - Kaapo Kakko Eeli Tolvanen - Chandler Stephenson - Oliver Bjorkstrand Jared McCann - Shane Wright - Yanni Gourde Tye Kartye - Ben Meyers - Daniel Sprong Vince Dunn - Adam Larsson Jamie Oleksiak - Brandon Montour Ryker Evans - Josh Mahura Philipp Grubauer Ales Stejka With the injured Joey Daccord not making the trip to Vancouver, expect the Kraken's starting goaltender to be Philipp Grubauer. He has an .877 save percentage this season and has picked up a win in just three of his 13 starts.Why your favorite catalogs are smaller this holiday season
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ATHENS, Ohio (AP) — AJ Clayton scored 16 points as Ohio beat Robert Morris 84-68 on Saturday. Clayton had seven rebounds for the Bobcats (3-5). Victor Searls scored 14 points and added seven rebounds. Jackson Paveletzke and Aidan Hadaway both scored 11 points. The Colonials (6-3) were led by Josh Omojafo, who recorded 15 points. Antallah Sandlin'El added 14 points for Robert Morris. Alvaro Folgueiras finished with 12 points and seven rebounds. The loss ended a six-game winning streak for the Colonials. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
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