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You’ve discovered some interesting biology and have a set of required parameters, thousands of data points, a budget and a deadline. How can you harness the power of computational chemistry to reach your next milestone faster, and more cost effectively? First-void urine (FVU) is emerging as a valuable sample type offering unique insights into various health conditions in clinical and research settings. Unlike midstream urine, FVU is collected at the start of urination, capturing the initial fraction that contains higher concentrations of cells, proteins, and other biomarkers shed from the urogenital tract. These characteristics make FVU particularly useful for detecting infections, cancers, and other diseases at an early stage. The significance of FVU lies in its potential to revolutionize diagnostic and monitoring practices. By providing a non-invasive, easily obtainable sample, FVU facilitates frequent and convenient testing, which is crucial for early detection and ongoing monitoring of diseases. This eBook delves into the science behind first-void urine, exploring its composition, collection methods, and the latest advancements in its application, as well as other potential applications of urine samples. We will examine how FVU is being utilized in various fields, from infectious disease diagnostics to cancer screening and beyond. The integration of advanced technologies, such as molecular diagnostics and biomarker discovery, enhances the utility of FVU enabling more accurate and comprehensive analyses. Through collaborative efforts and innovative research, the potential of FVU as a diagnostic tool continues to expand, offering new possibilities for improving patient outcomes. This eBook aims to provide a comprehensive overview of first-void urine as a sample type, highlighting its advantages, challenges, and future prospects. By understanding the unique properties and applications of FVU, researchers an better harness its potential to enhance diagnostic accuracy and patient care. Join us as we explore the transformative impact of firstvoid urine in the world of medical diagnostics.Qatar tribune Agencies Global food prices rose in November to their highest level since April 2023, the U.N. food agency said on Friday, recording the biggest gain in 19 months on the back of surging vegetable oil prices. The world food price index, compiled by the U.N. Food and Agriculture Organization (FAO) to track the most globally traded food commodities, increased to 127.5 points last month from a revised 126.9 points in October, the highest level in 19 months and up 5.7% from a year ago. The vegetable oil index jumped 7.5% above levels seen a month ago and 32% above those seen a year earlier, driven by concerns over lower-than-expected palm oil output due to excessive rainfall in Southeast Asia.Soyoil prices rose on stronger global import demand, while rapeseed and sunflower oil also increased. Cereal prices dropped 2.7% from October thanks to weaker wheat and rice prices, while sugar fell 2.4% from October as India and Thailand began crushing and concerns over Brazil’s crop prospects eased. In a separate report, the FAO trimmed its forecast for global cereal production in 2024 from 2.848 billion metric tons to 2.841 billion, a 0.6% decline from last year but still the second-largest output on record. World cereal utilization, meanwhile, is set to increase 0.6% to 2.859 billion tons in 2024/25 thanks to growing consumption.As a result, the FAO expects the cereal stocks-to-use ratio to fall to 30.1% at the close of the 2025 season from 30.8% previously, but still indicating a “comfortable level of global supply.” Copy 09/12/2024 10Additionally, it is crucial to listen to your body and pay attention to any warning signs or discomfort during the massage. If you experience unusual pain, numbness, or tingling, do not hesitate to speak up and ask the therapist to adjust their techniques or pressure.
Asset management funds in Pakistan exceed Rs. 3 trillion landmark
'He never liked retirement anyway': Andy Murray takes on new role in tennis
'He never liked retirement anyway': Andy Murray takes on new role in tennisOne of the key reasons why the coaching staff at Real Madrid believe Asensio is the best shooter in the team is his remarkable shot accuracy. Whether it's from long range or in a crowded penalty area, Asensio has a knack for finding the target with pinpoint precision. His ability to place the ball exactly where he wants it to go has earned him a reputation as one of the most clinical finishers in the game today.India is not pursuing the creation of a shared BRICS currency, an idea that has met with a strong verbal pushback from incoming U.S. President Donald Trump, but the South Asian giant is making efforts to promote trade in its local currency, according to analysts in New Delhi. Trump has threatened a 100% tariff on products from BRICS nations if they develop their own currency to replace the U.S. dollar. The BRICS bloc, which began with China, Russia, India, Brazil and South Africa, expanded this year to include Iran, the United Arab Emirates, Ethiopia and Egypt. “We require a commitment from these countries that they will neither create a new BRICS currency nor back any other currency to replace the mighty U.S. dollar,” Trump said in a post on the Truth Social media platform. Talk of a BRICS currency gained some momentum following U.S.-led sanctions on Russia in 2022 and since, in recent years, economic and political tensions have grown between the West and China. Russia and China have publicly expressed a desire to explore diversification of international trade away from the dollar. Ajai Sahai, director general of the Federation of Indian Export Organizations, though, said New Delhi does not plan to move away from the American currency. “Trump’s post is like a forewarning to tread carefully down this road. But at the moment, this is just an idea, and a common BRICS currency is simply not on India’s agenda,” Sahai said. The creation of such a currency is unlikely to gain traction due to mistrust and internal differences within major countries in the alliance such as India and China, according to analysts working in the Indian capital. “India is not supportive of this particular initiative. Any common currency is not going to help anyone; only the dominant countries like China ultimately will dictate. So, it is very difficult to develop a consensus to have a common currency,” according to Chintamani Mahapatra, founder of the Kalinga Institute of Indo Pacific Studies. The emerging countries group is also too diverse to make it economically viable to forge a competing currency, according to Mahapatra. “Unlike the European Union, we [BRICS countries] don’t have a common market. We don’t have a common trade policy. We have nothing in common,” Mahapatra said. At the same time, several BRICS members have accelerated efforts to explore ways to reduce dependence on the U.S. dollar, which has been the world’s dominant currency since the end of World War II. BRICS countries account for about 40% of the world’s population and an estimated one-third of global gross domestic product. At a summit held in the Russian city of Kazan in October, BRICS nations agreed to boost efforts to trade in local currencies rather than in U.S. dollars and said they would strengthen banking networks within the group to facilitate settlements in their currencies. “Trade in local currencies and smooth cross-border payments will strengthen our economic cooperation,” Indian Prime Minister Narendra Modi said. India, which adopted a new foreign trade policy last year to support using the rupee more frequently for trade, has identified 17 countries with which it wants to use rupees or the other country’s currency, according to Biswajit Dhar, a senior professor at the Council for Social Development in New Delhi. Those countries include Russia. New Delhi, which did not join U.S. sanctions against Russia, is paying for its crude oil imports from Moscow in rupees. As trade with Russia increases exponentially, though, that also presents problems. “India runs a huge trade deficit vis-a-vis Russia, which means that when India is buying a lot of oil and is paying in rupees, Russia does not know what to do with the stock of rupees it is holding now,” Dhar said. “Indian businesses are wary of selling to Russia because of the sanctions.” he said. Aside from Russia, other countries such as Malaysia, Kenya, Sri Lanka and Bangladesh also have agreed to facilitate trade in rupees. Such efforts however are modest, and India’s international trade is still dominated by the dollar. Indian External Affairs Minister Jaishankar Subramanian has said that moving away from the U.S. currency is not part of New Delhi’s economic policy. “We have never actively targeted the dollar. That's not part of either our economic policy or our political or strategic policy,” he said responding to a question on dedollarization at the Carnegie Endowment for International Peace in Washington in October. But in an indirect reference to Russia, he said that India had to look for “workarounds” when trade in dollars with some partners became difficult. “It was the U.S. actions targeting Russia that made countries search for mechanisms and options to the dollar. It was not to dislodge the dollar’s position,” according to Ajay Srivastava, of the Global Trade Research Initiative. However, he said Trump’s threat to impose 100% tariffs on products coming from countries adopting a BRICS currency makes the idea of such a potential new currency “unrealistic and more symbolic than practical.”
Sonic the Hedgehog 3 Movie Scheduled for Mainland China Release on January 10 Next Year
SINGAPORE, Nov. 21, 2024 (GLOBE NEWSWIRE) -- Bitdeer Technologies Group (Nasdaq: BTDR) (" Bitdeer ” or the " Company ”), a world-leading technology company for blockchain and high-performance computing, today announced that it intends to offer, subject to market conditions and other factors, US$360.0 million principal amount of Convertible Senior Notes due 2029 (the " notes ”) in a private placement (the " offering ”) to persons reasonably believed to be qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the " Securities Act ”). The Company also intends to grant the initial purchasers of the notes an option to purchase, within a 13-day period beginning on, and including, the date on which the notes are first issued, up to an additional US$40.0 million principal amount of notes. The notes will be general senior unsecured obligations of the Company and will accrue interest payable semiannually in arrears. Upon conversion, the Company will pay or deliver, as the case may be, cash, Class A ordinary shares par value US$0.0000001 per share, of the Company (the " Class A ordinary shares ”) or a combination of cash and Class A ordinary shares, at its election. The interest rate, initial conversion rate, repurchase or redemption rights and certain other terms of the notes will be determined at the time of pricing of the offering. The Company intends to use a portion of the net proceeds from the offering to pay the cost of the zero-strike call option transaction and to pay the cash consideration for the concurrent note exchange transactions, each as described below. The Company intends to use the remaining net proceeds from the offering for datacenter expansion, ASIC based mining rig development and manufacture, as well as working capital and other general corporate purposes. If the initial purchasers exercise their option to purchase additional notes, the Company expects to use the net proceeds from the sale of the additional notes for datacenter expansion, ASIC based mining rig development and manufacture, as well as working capital and other general corporate purposes as described above. In connection with the pricing of the notes, the Company intends to enter into a privately negotiated zero-strike call option transaction with one of the initial purchasers or its affiliate (the " option counterparty ”). Pursuant to the zero-strike call option transaction, the Company would pay a premium for the right to receive, without further payment, a specified number of Class A ordinary shares (subject to customary adjustment), with delivery thereof by the option counterparty at expiry, subject to early settlement of the zero-strike call option transaction in whole or in part at the option counterparty's discretion. In the case of settlement at expiration or upon any early settlement, the option counterparty would deliver to the Company the number of Class A ordinary shares underlying the zero-strike call option transaction or the portion thereof being settled early. The zero-strike call option transaction is intended to facilitate privately negotiated derivative transactions with respect to the Class A ordinary shares between the option counterparty (or its affiliate) and certain investors in the notes by which those investors will be able to hedge their investment in the notes. Those activities, which are expected to occur concurrently with or shortly after the pricing of the offering, could increase (or reduce the size of any decrease in) the market price of the Class A ordinary shares and/or the notes at that time. The option counterparty (or its affiliate) may modify its hedge positions by entering into or unwinding derivative transactions with respect to the Class A ordinary shares and/or purchasing or selling Class A ordinary shares or other securities of the Company in secondary market transactions at any time following the pricing of the notes and shortly before or after the expiry or early settlement of the zero-strike call option transaction, and, the Company has been advised that the option counterparty may unwind its derivative transactions and/or purchase or sell the Class A ordinary shares in connection with the expiry of the zero-strike call option transaction or any early settlement of the zero-strike call option transaction at the option counterparty's discretion, including any early settlement relating to any conversion, repurchase or redemption of the notes. Those activities could also increase (or reduce the size of any decrease in) or decrease (or reduce the size of any increase in) the market price of the Class A ordinary shares and/or the notes. If the zero-strike call option transaction fails to become effective, whether or not the offering is completed, the option counterparty may unwind its hedge positions with respect to the Class A ordinary shares, which could adversely affect the market price of the Class A ordinary shares and, if the notes have been issued, the market price of the notes. Concurrently with the pricing of the notes in the offering, the Company expects to enter into one or more privately negotiated transactions with one or more holders of 8.50% convertible senior notes due 2029 (the " existing 2029 notes ”) to exchange for cash and Class A ordinary shares certain of its existing 2029 notes on terms to be negotiated with each holder (each, a " note exchange transaction "). The terms of each note exchange transaction will depend on a variety of factors. No assurance can be given as to how much, if any, of the existing 2029 notes will be exchanged or the terms on which they will be exchanged. This press release is not an offer to exchange the existing 2029 notes, and the offering of the notes is not contingent upon the exchange of the existing 2029 notes. In connection with any note exchange transaction, the Company expects that holders of the existing 2029 notes who agree to have their existing 2029 notes exchanged and who have hedged their equity price risk with respect to such notes (the " hedged holders ”) will unwind all or part of their hedge positions by buying the Class A ordinary shares and/or entering into or unwinding various derivative transactions with respect to the Class A ordinary shares. The amount of the Class A ordinary shares to be purchased by the hedged holders or in connection with such derivative transactions may be substantial in relation to the historical average daily trading volume of the Class A ordinary shares. This activity by the hedged holders could increase (or reduce the size of any decrease in) the market price of the Class A ordinary shares, including concurrently with the pricing of the notes. The Company cannot predict the magnitude of such market activity or the overall effect it will have on the price of the notes or the Class A ordinary shares. The notes and any Class A ordinary shares issuable upon conversion of the notes have not been and will not be registered under the Securities Act, any state securities laws or the securities laws of any other jurisdiction, and unless so registered, may not be offered or sold in the United States absent registration or an applicable exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and other applicable securities laws. This press release is neither an offer to sell nor a solicitation of an offer to buy any of these securities nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to the registration or qualification thereof under the securities laws of any such state or jurisdiction. About Bitdeer Technologies Group Bitdeer is a world-leading technology company for blockchain and high-performance computing. Bitdeer is committed to providing comprehensive computing solutions for its customers. The Company handles complex processes involved in computing such as equipment procurement, transport logistics, datacenter design and construction, equipment management, and daily operations. The Company also offers advanced cloud capabilities to customers with high demand for artificial intelligence. Headquartered in Singapore, Bitdeer has deployed datacenters in the United States, Norway, and Bhutan. Forward-Looking Statements Statements in this press release about future expectations, plans, and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. The words "anticipate,” "look forward to,” "believe,” "continue,” "could,” "estimate,” "expect,” "intend,” "may,” "plan,” "potential,” "predict,” "project,” "should,” "target,” "will,” "would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Such forward-looking statements include, among others, statements relating to Bitdeer's expectations regarding the proposed terms and the completion, timing and size of the proposed offering, the note exchange transactions and the zero-strike call option transaction, the expected use of proceeds from the sale of the notes and potential impact of the foregoing or related transactions on the market price of the Class A ordinary shares or the trading price of the notes. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including risks and uncertainties associated with market conditions, whether Bitdeer will offer the notes, enter into the note exchange transactions and the zero-strike call option transaction or be able to consummate the proposed offering, the note exchange transactions and the zero-strike call option transaction at the anticipated size or on the anticipated terms, or at all, and the satisfaction of closing conditions related to the proposed offering and the note exchange transactions, as well as discussions of potential risks, uncertainties and other factors discussed in the section entitled "Risk Factors” in Bitdeer's annual report on Form 20-F, as well as those discussed in Bitdeer's subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements as there are important factors that could cause actual results to differ materially from those in forward-looking statements, many of which are beyond Bitdeer's control. Any forward-looking statements contained in this press release speak only as of the date hereof. Bitdeer specifically disclaims any obligation to update any forward-looking statement, whether due to new information, future events, or otherwise. Readers should not rely upon the information on this page as current or accurate after its publication date. For investor and media inquiries, please contact: Investor Relations Yujia Zhai Orange Group [email protected] Public Relations Nishant Sharma BlocksBridge Consulting [email protected]
Beyond equities, other asset classes have also seen significant gains in the late-night trading sessions. The bond market, in particular, has witnessed heightened activity, as investors seek safe-haven assets in the midst of global uncertainties. Chinese government bonds, known for their relatively high yields and stability, have attracted a wave of interest from both domestic and international investors.