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JERUSALEM (AP) — Israel’s attorney general has ordered police to open an investigation into Prime Minister Benjamin Netanyahu’s wife on suspicion of harassing political opponents and witnesses in the Israeli leader’s corruption trial. The Israeli Justice Ministry made the announcement in a terse message late Thursday., saying the investigation would focus on the findings of a recent report by the “Uvda” investigative program into Sara Netanyahu. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.Cowboys shutting down CeeDee Lamb with 2 games to go over receiver's shoulder issue FRISCO, Texas (AP) — The Dallas Cowboys are shutting down CeeDee Lamb with two games remaining after their 2023 All-Pro receiver spent the second half of the season dealing with a sprained right shoulder. Canadian Press Dec 26, 2024 2:44 PM Dec 26, 2024 3:05 PM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Dallas Cowboys wide receiver CeeDee Lamb (88) breaks a tackle attempt by Tampa Bay Buccaneers linebacker Lavonte David (54) in the first half of an NFL football game in Arlington, Texas, Sunday, Dec. 22, 2024. (AP Photo/Jeffrey McWhorter) FRISCO, Texas (AP) — The Dallas Cowboys are shutting down CeeDee Lamb with two games remaining after their 2023 All-Pro receiver spent the second half of the season dealing with a sprained right shoulder. The team said Thursday that additional exams revealed enough damage to keep Lamb off the field Sunday at Philadelphia and in the final game at home against Washington. The team said surgery was not expected to be required. Dallas was eliminated from playoff contention a few hours before last weekend's 26-24 victory over Tampa Bay . The decision on Lamb means the Cowboys will finish the regular season with at least five former Pro Bowlers on injured reserve. Among the others are quarterback Dak Prescott, who was limited to eight games before a season-ending hamstring tear, and right guard Zack Martin. The seven-time All-Pro made it through 10 games before deciding on season-ending ankle surgery. Defensive end DeMarcus Lawrence didn't playing after Week 4 because of a foot injury, and cornerback Trevon Diggs battled a variety of injuries while playing 11 games before a knee injury ended his season. Lamb initially injured his right shoulder when it hit the turf hard twice in a 27-21 loss at Atlanta on Nov. 3. He kept playing and had at least 100 yards in each of his last two games — both victories — before getting shut down. The 25-year-old Lamb sat out the entire offseason and preseason in a contract dispute after getting career highs in catches (an NFL-best 135), yards receiving (club-record 1,749) and touchdowns (12) in 2023. The holdout finally ended with a $136 million, four-year extension in late August, but neither the Cowboys nor their star receiver could get that production going again this season. Dallas (7-8) is missing the playoffs for the first time since 2020, Lamb's rookie year. Lamb finishes the season with 101 catches for 1,194 yards and six TDs. ___ AP NFL: https://apnews.com/NFL The Associated Press See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Get your daily Victoria news briefing Email Sign Up More Football (NFL) Eagles try to clinch NFC East title with Hurts' head injury looming large Dec 26, 2024 3:04 PM Michigan defensive lineman Kenneth Grant declares for NFL draft Dec 26, 2024 3:01 PM Chargers focused on avoiding a letdown and not a potential playoff berth in matchup with Patriots Dec 26, 2024 2:43 PM
The events of the Nov. 5 presidential election divided states, demographics and, in many cases, families. President-elect Donald Trump’s supporters celebrated the Republican candidate’s victory, while many who championed Democratic Vice President Kamala Harris fell into despair. With Thanksgiving, Christmas, Hanukkah and other holidays following so closely on the heels of Election Day, the emotional wounds that opened between family members on different sides of the political divide are still fresh — and could affect how families celebrate the holidays. Local mental health professionals are reporting an uptick in anxiety, anger, confusion and depression among their patients. Some of those negative emotions are caused by family conflicts. “Something like politics, culture, these are issues that we as humans don’t really have as much control over, so there’s that helplessness that my clients feel regarding the election,” said licensed social worker Amber Kanoza of Pittsburgh’s Carrick neighborhood. “It’s been quite a turbulent past couple of weeks, being able to navigate what it all means,” said music therapist Elizabeth Ambrose of Pittsburgh’s East Liberty. Several local residents declined to talk on the record to TribLive about their holiday plans, citing concerns that doing so would inflame already tense relationships. Even under normal circumstances, the holidays can be stressful. But with these heightened conditions, local professionals offered strategies that they’re giving their patients to survive any verbal missiles lobbed over turkey and mashed potatoes. Should I stay or should I go? For those weighing the decision of whether to opt out of a family gathering, licensed social worker Jess Schiermeister — who sees clients at a private practice in Hampton — said people should look at the pros and cons. “I always encourage folks to do a cost-benefit analysis,” she said. “Which option would have a more harmful impact to them?” Many therapists stressed the importance of setting boundaries. Ambrose has put that into practice in her personal life as well. “Even now, with politics being so polarized, a lot of those discussions can go awry very quickly, and being in certain settings, feelings can become elevated,” she said. “I’ve found success in trying to avoid and protect my peace as much as I can.” Setting boundaries includes warning family members ahead of time about topics you won’t discuss and removing yourself from the situation if those wishes are repeatedly ignored. “I recognize that’s really hard,” Ambrose said. “Try to have those firm boundaries and be very upfront.” Keep your feet on the ground Two pieces of advice consistently arose among the pros for those keeping their regular holiday traditions: Have a plan and keep your emotions under control. Kanoza suggested grounding and mindfulness exercises. “The purpose of doing that is having a sense of awareness for yourself: What do I need? How am I feeling? Where am I feeling this stress?” she said. Taking five minutes to breathe, meditate and take stock of your body and mind beforehand can be a big help. Schiermeister suggested going so far as writing a script in your phone’s notes app for how you will respond to unwanted political talk. Aaron Beckley, a licensed clinical social worker in private practice in Hampton, recommended a technique called “gray rocking.” “Imagine yourself as a rock,” Beckley said. “If it rains, you’re a rock; it doesn’t matter. If the sun beats down, you’re a rock. Imagine yourself that way, no matter what they say. Your emotions are yours. How you express them is under your control.” Self-care matters If things get heated, there are strategies to employ during — and after — to lower your stress levels. Being a music therapist, Ambrose often directs clients to make carefully curated playlists to help with emotional regulation. Start with music that matches your anger or anxiety, then taper off. “Slowly decrease it or move it to a place where maybe there’s some calmer music at the tail end of the playlist, moving ... from a ragey state to a more relaxed place,” she said. Feel free to take a break. If a conversation is escalating, “Go hang out with the dog for a while, go outside, take a walk, go to the bathroom, call a friend, say a prayer, do whatever works,” said Mike Elliot, licensed professional counselor and clinical director of Elliot Counseling in East Liberty. Creating a “self-soothe kit” is a way to relax all five senses, Schiermeister said. Bundle items you find comforting using the guide of smell, taste, touch, sight and sound. “Is there a particular soft blanket they like? Is there a particular candle that they really enjoy? Is there a TV show that always brings them comfort?” Elliot said. These collections can be made portable in the midst of heightened situations. Take a square of your favorite chocolate, some great-smelling lotion and other objects in a purse, or leave them in your car for easy access. Building a found family For the 23% who are avoiding their relatives this year, finding a community of their own will be an important step. “Really lean on the people who are going through similar issues as you. What we can do is help comfort each other,” Kanoza said. No matter the politics, people may feel walled off from their typical support system for any number of reasons. Schiermeister said they shouldn’t feel lonely. “The week of the election, every single one of my clients said that they felt alone — all of them. And obviously they’re not, because each and every one of them said that to me,” she said. Hosting a “Friendsgiving” event and finding new ways to celebrate traditions will help keep the holidays bright. “I’d recommend looking at it the same way that someone would feel with grief, like if a loved one died and this was the first holiday without them,” Beckley said. “Remember those positive times. What were the traditions that were meaningful? How do I take that and do it for myself to hold the meaning that I want?” Bridging the divide Eventually working to heal the divide will require patience, self-reflection and acknowledgment of others’ feelings. With just a little more than three weeks between the presidential contest and the start of the holiday season, some will have to understand that there just hasn’t been time to process yet. Compassion for everyone will be required. “Try to be more mindful and try to be more empathetic as to why those individuals are reacting the way that they are. There’s space to grow and investigate,” Kanoza said. Schiermeister hopes there could be more space for listening, not just reacting. “And when I say listening, I don’t mean immediately becoming defensive or turning it into an argument,” she said. “Pointing fingers at each other isn’t getting us anywhere,” Elliot said. “So I think, where I can come in and have a positive conversation? I’m going to try to do that. And where I don’t feel that’s possible, I’m going to keep walking.”
At this point, has been discussed enough for investors to know it's a big deal. The explosive growth in 's ( ) business results and its stock price prove the point. But unless you're closely following Nvidia CEO Jensen Huang, you may not comprehend just how big AI can get. Huang has used the term "sovereign AI" in past discussions. He just gave investors a look at what it really means and why it is great news for Nvidia shareholders. Huang just met with the prime ministers of Thailand and Vietnam on a trip to Southeast Asia in early December. He wants to help countries in the region — and around the world — utilise domestic data and labour, along with expanding computing infrastructure, to develop and exploit AI. And the market looks to be massive. Unparalleled growth It's hard to imagine that Nvidia can continue on its astounding growth path. Sales exploded in the current fiscal year. Over the past nine months, Nvidia reported revenue of $91.2 billion. That's an increase of 135% over the $38.8 billion reported in the prior year period. It's more than quadruple the sales from two years ago. Most of that is due to Nvidia's data centre segment, as big companies are spending large amounts of capital to quickly meet the computing power that is needed for AI applications. Of course, investors have noticed, and the stock has also exploded higher, with a three-year gain of 340%. One would think that the growth rate will eventually drop, but Nvidia is still capacity-constrained with demand still growing. Nvidia is also working to hold off competition with its Blackwell GPU (graphics processing units) architecture launch this year and is already announcing the Rubin platform to succeed Blackwell. Explaining the company's development plans, Huang has stated, "Our company has a one-year rhythm. Our basic philosophy is very simple: Build the entire data center scale, disaggregate and sell to [customers] parts on a one-year rhythm, and push everything to technology limits." And Huang knows demand is going to spread beyond the large tech companies. That's where sovereign AI comes in, and that is why Huang has been travelling the globe in recent months. A $20 trillion market Huang's recent Southeast Asia trip kicked off with a meeting with Thailand's prime minister. They discussed how investing in AI can propel innovation in the country in many fields that will benefit Thai citizens. Huang promoted sovereign AI for Thailand this way: The most important part of artificial intelligence is the data. And the data of Thailand belongs to the Thai people. The digital data of Thailand encodes the knowledge, the history, the culture, the common sense of your people. It should be harvested by your people. And that applies to many countries. A recent paper published by the global market intelligence and data provider International Data Corporation (IDC) says that AI will contribute $19.9 trillion to the global economy just through the remainder of this decade. By 2030, it is believed 3.5% of global GDP will be driven by AI investments. Nvidia boots on the ground Nvidia is leading the way, not just with its market-leading AI platform offerings. Huang's visit to Southeast Asia had some concrete takeaways. He announced that Nvidia would be opening a new research and development (R&D) centre in Vietnam to accelerate AI development. The centre plans to nurture innovation in several sectors of the fast-growing economy. Huang says it will partner with Vietnamese researchers, start-ups, and other business organisations. The country is not new to Nvidia. The company says it has been investing in Vietnam's technology ecosystem for eight years. That includes engaging with dozens of AI start-up companies and universities in the country. Investors should be paying attention to what Huang is saying and doing. His recent visit to Southeast Asia provides somewhat of a blueprint for how capital investments in AI will continue to grow. That should continue to make Nvidia shareholders happy in coming months and years.Judge halts $25 billion Kroger-Albertsons mergerIRVING, Texas (AP) — A rape allegation against rapper Jay-Z, whose company Roc Nation has produced some of the NFL's entertainment presentations including the Super Bowl halftime show, won’t impact the league's relationship with the music mogul. “We’re aware of the civil allegations and Jay-Z’s really strong response to that," NFL Commissioner Roger Goodell said Wednesday after the conclusion of the league's winter meetings. "We know the litigation is happening now. From our standpoint, our relationship is not changing with them, including our preparations for the next Super Bowl.” A woman who previously sued Sean “Diddy” Combs, alleging she was raped at an awards show after-party in 2000 when she was 13 years old, amended the lawsuit Sunday to include a new allegation that Jay-Z was also at the party and participated in the sexual assault. Jay-Z, whose real name is Shawn Carter, said the rape allegation made against him is part of an extortion attempt . The 24-time Grammy Award winner called the allegations “idiotic” and “heinous in nature” in a statement released by Roc Nation, one of his companies. The NFL teamed up with Jay-Z’s Roc Nation in 2019 for events and social activism. The league and the entertainment company extended their partnership a few months ago. Kendrick Lamar will perform the Super Bowl halftime show at The Caesars Superdome in New Orleans on Feb. 9. Roc Nation and Emmy-winning producer Jesse Collins will serve as co-executive producers of the halftime show. Beyonce, who is married to Jay-Z, will perform at halftime of the Baltimore Ravens-Houston Texans game on Christmas. “I think they’re getting incredibly comfortable with not just with the Super Bowl but other events they’ve advised us on and helped us with,” Goodell said. “They’ve been a big help in the social justice area to us on many occasions. They’ve been great partners.” AP NFL: https://apnews.com/hub/nfl
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What did you Google in 2024? From the elections to Copa América, here's what search trends showThe large mysterious drones reported flying over parts of New Jersey in recent weeks appear to avoid detection by traditional methods such as helicopter and radio, according to a state lawmaker briefed Wednesday by the Department of Homeland Security. In a post on the social media platform X, Assemblywoman Dawn Fantasia described the drones as up to 6 feet in diameter and sometimes traveling with their lights switched off. The Morris County Republican was among several state and local lawmakers who met with state police and Homeland Security officials to discuss the spate of sightings that range from the New York City area through New Jersey and westward into parts of Pennsylvania, including over Philadelphia.NEW YORK (AP) — Remember what you searched for in 2024? Google does. Google released its annual “Year in Search” on Tuesday, rounding up the top trending queries entered into its namesake search engine in 2024. The results show terms that saw the highest spike in traffic compared to last year — ranging from key news events, notably global elections , to the most popular songs, athletes and unforgettable pop-culture moments that people looked up worldwide. Sports — particularly soccer and cricket — dominated Google's overall trending searches in 2024. Copa América topped those search trends globally, followed by the UEFA European Championship and ICC Men's T20 World Cup . Meanwhile, the U.S. election led news-specific searches worldwide. Queries about excessive heat and this year's Olympic Games followed. U.S. President-elect Donald Trump topped searches in Google's people category this year — followed by Catherine, Princess of Wales , U.S. Vice President Kamala Harris and Algerian boxer Imane Khelif , who also led athlete-specific searches. Meanwhile, the late Liam Payne , Toby Keith and O.J. Simpson led search trends among notable individuals who died in 2024. In the world of entertainment, Disney and Pixar's “Inside Out 2” was the top trending movie of the year, while Netflix's “Baby Reindeer” led TV show trends. And Kendrick Lamar’s “Not Like Us” dominated song trends. That's just the tip of the iceberg. Queries for the Olympic village's chocolate muffin , made famous by Norwegian swimmer Henrik Christiansen over the summer games, led Google's global recipe trends this year. The New York Times' “Connections” puzzle topped game searches. And in the U.S., country-specific data shows, many people asked Google about online trends like the word “demure” and “ mob wife aesthetic .” You can find more country-specific lists, and trends from years past , through Google’s “Year in Search” data published online . The California company said it collected 2024 search results from Jan. 1 through Nov. 23 of this year. Google isn't the only one to publish an annual recap or top trends as 2024 draws to a close. Spotify Wrapped , for example, as well as Collins Dictionary and Merriam-Webster’s words of the year, have offered additional reflections for 2024. The Associated Press
AP Trending SummaryBrief at 5:56 p.m. EST
AP Trending SummaryBrief at 5:56 p.m. EST
Statistics after 11 gamesMGX-001, utilizing a highly specific and efficient MG29-1 nuclease, exhibits no identifiable off-target editing MG29-1 nuclease targeting the albumin safe harbor locus showed no evidence of translocations in primary human hepatocytes Metagenomi Adenine Base Editor (ABE) demonstrates no detectable translocations and no significant genomic base composition differences in primary T-cells EMERYVILLE, Calif., Dec. 11, 2024 (GLOBE NEWSWIRE) -- Metagenomi, Inc. (Nasdaq: MGX), a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary gene editing toolbox, today presented a talk titled “Specific and efficient genome editing with metagenomics-derived tools for in vivo and ex vivo therapeutic applications” at the Nature Conference: RNA at the Bench and Bedside IV. “We believe the value proposition for single-dose gene editing therapies requires exquisite specificity characterization to ensure safety and efficacy. Today’s presentation highlights the precision of Metagenomi’s next-generation nucleases and ABEs, discovered through the company’s proprietary metagenomics platform and tailored for both in vivo and ex vivo therapeutic applications,” said Alan Brooks, SVP and Head of Preclinical. “MGX-001, Metagenomi’s development candidate for hemophilia A, which utilizes the novel nuclease MG29-1, exhibits no identifiable off-target editing using a series of orthogonal assays employed to evaluate potential off-target sites in the genome. The MG29-1 nuclease targeting the albumin safe harbor locus showed no evidence of translocations in primary human hepatocytes. For Metagenomi’s novel next-generation ABE for ex vivo cell therapy indications via multiplex editing, the data showed no detectable translocations and no significant genomic base composition differences in primary T-cells when compared to unedited cells. These examples demonstrate our strong capabilities in developing highly specific next-generation gene editing tools and support the company’s ability to potentially progress these systems toward the clinic for the benefit of patients.” About Metagenomi Metagenomi is a precision genetic medicines company committed to developing curative therapeutics for patients using its proprietary, comprehensive metagenomics-derived toolbox. Metagenomi is harnessing the power of metagenomics, the study of genetic material recovered from the natural environment, to unlock four billion years of microbial evolution to discover and develop a suite of novel editing tools capable of correcting any type of genetic mutation found anywhere in the genome. Its comprehensive genome editing toolbox includes programmable nucleases, base editors, and RNA and DNA-mediated integration systems (including prime editing systems and clustered regularly interspaced short palindromic repeat associated transposases (CAST)). Metagenomi believes its diverse and modular toolbox positions the company to access the entire genome and select the optimal tool to unlock the full potential of genome editing for patients. For more information, please visit https://metagenomi.co. Cautionary Note Regarding Forward‐Looking Statements This press release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions, include, but are not limited to, any statements relating to our growth strategy and product development programs, including the timing of and our ability to conduct IND-enabling studies, make regulatory filings such as INDs, statements concerning the potential of therapies and product candidates, and any other statements that are not historical facts. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under, and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in “Risk Factors,” in our most recent Form 10-K and our most recent 10-Qs on file with the Securities and Exchange Commission. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Contact: Simon Harnest - CIO, SVP Investor Relations IR@metagenomi.coASIPONA Puerto Vallarta: Innovation And Excellence For Cruise Passengers Arriving In Puerto Vallarta
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