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2025-01-19
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8bet casino NoneAs part of a national “moonshot” to cure blindness, researchers at the CU Anschutz Medical Campus will receive as much as $46 million in federal funding over the next five years to pursue a first-of-its-kind full eye transplantation. “This is no easy undertaking, but I believe we can achieve this together,” said Dr. Kia Washington, the lead researcher for the University of Colorado-led team, during a press conference Monday. “And in fact I’ve never been more hopeful that a cure for blindness is within reach.” The CU team was one of four in the United States that received funding awards from the federal Advanced Research Projects Agency for Health , or ARPA-H. The CU-based group will focus on achieving the first-ever vision-restoring eye transplant by using “novel stem cell and bioelectronic technologies,” according to a news release announcing the funding. The work will be interdisciplinary, Washington and others said, and will link together researchers at institutions across the country. The four teams that received the funding will work alongside each other on distinct approaches, though officials said the teams would likely collaborate and eventually may merge depending on which research avenues show the most promise toward achieving the ultimate goal of transplanting an eye and curing blindness. Dr. Calvin Roberts, who will oversee the broader project for ARPA-H, said the agency wanted to take multiple “shots on goal” to ensure progress. “In the broader picture, achieving this would be probably the most monumental task in medicine within the last several decades,” said Dr. Daniel Pelaez of the University of Miami’s Bascom Palmer Eye Institute, which also received ARPA-H funding. Pelaez is the lead investigator for that team, which has pursued new procedures to successfully remove and preserve eyes from donors, amid other research. He told The Denver Post that only four organ systems have not been successfully transplanted: the inner ear, the brain, the spinal cord and the eye. All four are part of the central nervous system, which does not repair itself when damaged. If researchers can successfully transplant the human eye and restore vision to the patient, it might help unlock deeper discoveries about repairing damage to the brain and spine, Pelaez said, as well as addressing hearing loss. To succeed, researchers must successfully remove and preserve eyes from donors and then successfully connect and repair the optical nerve, which takes information from the eye and tells the brain what the eye sees. A team at New York University performed a full eye transplant on a human patient in November 2023, though the procedure — while a “remarkable achievement,” Pelaez said — did not restore the patient’s vision. It was also part of a partial face transplant; other approaches pursued via the ARPA-H funding will involve eye-specific transplants. Washington, the lead CU researcher, said she and her colleagues have already completed the eye transplant procedure — albeit without vision restoration — in rats. The CU team will next work on large animals to advance “optic nerve regenerative strategies,” the school said, as well as to study immunosuppression, which is critical to ensuring that patients’ immune systems don’t reject a donated organ. The goal is to eventually advance to human trials. Pelaez and his colleagues have completed their eye-removal procedure in cadavers, he said, and they’ve also studied regeneration in several animals that are capable of regenerating parts of their eyes, like salamanders or zebra fish. His team’s funding will focus in part on a life-support machine for the eye to keep it healthy and viable during the removal process. InGel Therapeutics, a Massachusetts-based Harvard spinoff and the lead of a third team, will pursue research on 3-D printed technology and “micro-tunneled scaffolds” that carry certain types of stem cells as part of a focus on optical nerve regeneration and repair, ARPA-H said. ARPH-A, created two years ago, will oversee the teams’ work. Researchers at 52 institutions nationwide will also contribute to the teams. The CU-led group will include researchers from the University of Southern California, the University of Wisconsin, Indiana University and Johns Hopkins University, as well as from the National Eye Institute . The teams will simultaneously compete and collaborate: Pelaez said his team has communicated with researchers at CU and at Stanford, another award recipient, about their eye-removal research. The total funding available for the teams is $125 million, ARPA-H officials said Monday, and it will be distributed in phases, in part dependent on teams’ success. U.S. Rep. Diana DeGette, a Democrat who represents Denver in Congress, acknowledged the recent election results at the press conference Monday and pledged to continue fighting to preserve ARPA-H’s funding under President-elect Donald Trump’s administration. The effort to cure blindness, Washington joked, was “biblical” in its enormity — a reference to the Bible story in which Jesus cures a blind man. She and others also likened it to a moonshot, meaning the effort to successfully put Neil Armstrong and Buzz Aldrin on the moon nearly 50 years ago. If curing blindness is similar to landing on the moon, then the space shuttle has already left the launchpad, Washington said. “We have launched,” she said, “and we are on our trajectory.”It looked like a recipe for disaster. So, when his country's swimmers were being accused of doping earlier this year, one Chinese official cooked up something fast. He blamed it on contaminated noodles. In fact, he argued, it could have been a culinary conspiracy concocted by criminals, whose actions led to the cooking wine used to prepare the noodles being laced with a banned heart drug that found its way into an athlete's system. This theory was spelled out to international anti-doping officials during a meeting and, after weeks of wrangling, finally made it into the thousands of pages of data handed over to the lawyer who investigated the case involving 23 Chinese swimmers who had tested positive for that same drug. The attorney, appointed by the World Anti-Doping Agency, refused to consider that scenario as he sifted through the evidence. In spelling out his reasoning, lawyer Eric Cottier paid heed to the half-baked nature of the theory. “The Investigator considers this scenario, which he has described in the conditional tense, to be possible, no less, no more,” Cottier wrote. Even without the contaminated-noodles theory, Cottier found problems with the way WADA and the Chinese handled the case but ultimately determined WADA had acted reasonably in not appealing China's conclusion that its athletes had been inadvertently contaminated. Critics of the way the China case was handled can't help but wonder if a wider exploration of the noodle theory, details of which were discovered by The Associated Press via notes and emails from after the meeting where it was delivered, might have lent a different flavor to Cottier's conclusions. “There are more story twists to the ways the Chinese explain the TMZ case than a James Bond movie,” said Rob Koehler, the director general of the advocacy group Global Athlete. "And all of it is complete fiction.” In April, reporting from the New York Times and the German broadcaster ARD revealed that the 23 Chinese swimmers had tested positive for the banned heart medication trimetazidine, also known as TMZ. China's anti-doping agency determined the athletes had been contaminated, and so, did not sanction them. WADA accepted that explanation , did not press the case further, and China was never made to deliver a public notice about the “no-fault findings,” as is often seen in similar cases. The stock explanation for the contamination was that traces of TMZ were found in the kitchen of a hotel where the swimmers were staying. In his 58-page report , Cottier relayed some suspicions about the feasibility of that chain of events — noting that WADA's chief scientist “saw no other solution than to accept it, even if he continued to have doubts about the reality of contamination as described by the Chinese authorities.” But without evidence to support pursuing the case, and with the chance of winning an appeal at almost nil, Cottier determined WADA's “decision not to appeal appears indisputably reasonable.” A mystery remained: How did those traces of TMZ get into the kitchen? Shortly after the doping positives were revealed, the Institute of National Anti-Doping Organizations held a meeting on April 30 where it heard from the leader of China's agency, Li Zhiquan. Li's presentation was mostly filled with the same talking points that have been delivered throughout the saga — that the positive tests resulted from contamination from the kitchen. But he expanded on one way the kitchen might have become contaminated, harkening to another case in China involving a low-level TMZ positive. A pharmaceutical factory, he explained, had used industrial alcohol in the distillation process for producing TMZ. The industrial alcohol laced with the drug “then entered the market through illegal channels,” he said. The alcohol "was re-used by the perpetrators to process and produce cooking wine, which is an important seasoning used locally to make beef noodles,” Li said. “The contaminated beef noodles were consumed by that athlete, resulting in an extremely low concentration of TMZ in the positive sample. "The wrongdoers involved have been brought to justice.” This new information raised eyebrows among the anti-doping leaders listening to Li's report. So much so that over the next month, several emails ensued to make sure the details about the noodles and wine made their way to WADA lawyers, who could then pass it onto Cottier. Eventually, Li did pass on the information to WADA general counsel Ross Wenzel and, just to be sure, one of the anti-doping leaders forwarded it, as well, according to the emails seen by the AP. All this came with Li's request that the noodles story be kept confidential. Turns out, it made it into Cottier's report, though he took the information with a grain of salt. “Indeed, giving it more attention would have required it to be documented, then scientifically verified and validated,” he wrote. Neither Wenzel nor officials at the Chinese anti-doping agency returned messages from AP asking about the noodles conspiracy and the other athlete who Li suggested had been contaminated by them. Meanwhile, 11 of the swimmers who originally tested positive competed at the Paris Games earlier this year in a meet held under the cloud of the Chinese doping case. Though WADA considers the case closed, Koehler and others point to situations like this as one of many reasons that an investigation by someone other than Cottier, who was hired by WADA, is still needed. “It gives the appearance that people are just making things up as they go along on this, and hoping the story just goes away," Koehler said. “Which clearly it has not.” AP Olympics: https://apnews.com/hub/2024-paris-olympic-games

No. 2 Auburn arrives for prove-it game at No. 9 Duke3 recipes to help you through the busy holiday season

3 recipes to help you through the busy holiday season

Noodles and wine are the secret ingredients for a strange new twist in China's doping sagaCanada's Trudeau says he had an 'excellent conversation' with Trump in Florida after tariffs threatHigher fuel consumption puts state exchequer in top gear

Demonstrators arrested outside Speaker Johnson’s office for protesting bathroom ban

Tests keep coming for Auburn and Duke, who collide at Cameron Indoor Stadium in a typical prove-it game in a rare environment on Wednesday night. No. 2 Auburn and No. 9 Duke square off less than one month into the season as two of the most battle-tested teams in basketball. They're matched as one of the marquee games in the crossover showcase known as the ACC-SEC Challenge. Auburn (7-0) jumped two spots in the latest Top 25 poll propelled by its Maui Invitational championship. In one of Feast Week's toughest brackets, the Tigers rallied from 18 points down to beat then-No. 4 Iowa State, handled then-No. 12 North Carolina 85-72 and rolled past Memphis 90-76 in the title game. With a week off to shed any remnants of jet lag returning from the islands, Auburn head coach Bruce Pearl is pointing to another potential resume-building win. "The confidence that we're going to get from (Maui) is that we know we can play with anybody," Pearl said. "I promise you this, we'll stay humble and hungry. We will not begin to think too much of ourselves." Helping lead Auburn in Maui was fifth-year power forward Johni Broome. The tournament's MVP, Broome averaged 21.7 points, 15 rebounds, 4.3 assists and three blocks in the three-game sweep. Spearheading a veteran Tigers roster, Broome couldn't care less about individual honors. "I wanted to come to a place where the foundation was already built, and that's why I came to Auburn," Broome said. "Winning player of the year doesn't matter to me. I care about winning games, and making sure I can help my team in any way." Broome's 20.7 points and 12.9 rebounds per game lead the Tigers, while Chad Baker-Mazara adds 12.6 ppg and Denver Jones chips in 11.1. Auburn's next roadblock is earning its first-ever win against Duke. The Tigers are 0-3 all-time against the Blue Devils, including a six-point loss in the 2018 Maui Invitational. Duke (5-2) has already been through three games against ranked opponents. The Blue Devils had a 77-72 loss against then-No. 19 Kentucky, a 14-point win at then-No. 17 Arizona and a 75-72 defeat against No. 1 Kansas last week in Las Vegas. "Best team we've played so far," Pearl said of Duke. Bouncing back on Friday, the Blue Devils took down Seattle 70-48, holding the Redhawks to just 10 made field goals on 47 attempts (21.3 percent). Despite the suffocating defensive effort, Duke head coach Jon Scheyer knows his team has a long way to go. "I wasn't really happy with much tonight, to be honest," Scheyer said on Friday. "I thought we rushed some shots, had too many turnovers. We need to finish stronger, drive stronger, make extra passes, there were a whole bunch of things. ... We just need to get back to practice. In fairness to our guys, we've been traveling a lot and we just need practice time." Pacing the Blue Devils in scoring is five-star freshman Cooper Flagg. He's averaging 15.9 points per game to go along with 8.3 rebounds. Fellow freshman Kon Knueppel adds 13.4 points per contest. Far less seasoned raw freshman, big man Khaman Maluach has given Duke's interior defense an edge it was lacking last season. A projected lottery pick who can be overshadowed by the Flagg publicity train, Maluach (7-2, 248) is averaging 8.4 points, 5.0 rebounds and has two three-block games. In last year's inaugural ACC-SEC Challenge, Duke lost at Arkansas 80-75 and Auburn topped Virginia Tech 74-57. --Field Level Media

Los Angeles Chargers (7-4) at Atlanta (6-5) Sunday, 1 p.m. EST, CBS BetMGM NFL Odds: Chargers by 1 1/2 Series record: Falcons lead 8-4. Against the spread: Chargers 7-3-1, Falcons 5-6. Last meeting: Chargers beat Falcons 20-17 on Nov. 6, 2022, in Atlanta. Last week: Ravens beat Chargers, 30-23; Falcons had bye week following 38-6 loss at Denver on Nov. 17. Chargers offense: overall (21), rush (13), pass (20), scoring (18). Chargers defense: overall (13), rush (10), pass (10), scoring (13). Falcons offense: overall (8), rush (14), pass (5), scoring (16). Falcons defense: overall (25), rush (19), pass (26), scoring (26). Turnover differential: Chargers plus-8, Falcons minus-3. Chargers player to watch RB Gus Edwards will move up as the lead back for Los Angeles after J.K Dobbins (knee) was placed on injured reserve on Saturday. Edwards was activated from IR earlier this month following an ankle injury and had nine carries for 11 yards with a touchdown in Monday night's 30-23 loss to Baltimore. Falcons player to watch WR Drake London has 61 catches, leaving him four away from becoming the first player in team history to have at least 65 receptions in each of his first three seasons. London has 710 receiving yards, leaving him 140 away from becoming the first player in team history with at least 850 in each of his first three seasons. Key matchup Falcons RB Bijan Robinson vs. Chargers' run defense. Robinson was shut down by Denver, gaining only 35 yards on 12 carries, and the Atlanta offense couldn't recover. The Chargers rank 10th in the league against the run, so it will be a challenge for the Falcons to find a way to establish a ground game with Robinson and Tyler Allgeier. A solid running attack would create an opportunity for offensive coordinator Zac Robinson to establish the play-action passes for quarterback Kirk Cousins. Key injuries Besides Dobbins, the Chargers also placed S Alohi Gilman (hamstring) on injured reserve. CB Cam Hart (ankle) and LB Denzel Perryman (groin) also have been ruled out. ... The Falcons needed the bye to give a long list of injured players an opportunity to heal. WR WR KhaDarel Hodge (neck) did not practice on Wednesday. WR Darnell Mooney (Achilles), CB Kevin King (concussion), DL Zach Harrison (knee, Achilles) and WR Casey Washington (concussion) were hurt in the 38-6 loss at Denver on Nov. 17 and were limited on Wednesday. CB Mike Hughes (neck), nickel back Dee Alford (hamstring), ILB Troy Andersen (knee), TE Charlie Woerner (concussion) and ILB JD Bertrand (concussion) also were limited on Wednesday after not playing against Denver. C Drew Dalman (ankle) could return. Series notes The Chargers have won the past three games in the series following six consecutive wins by the Falcons from 1991-2012. Los Angeles took a 33-30 overtime win in Atlanta in 2016 before the Chargers added 20-17 wins at home in 2020 and in Atlanta in 2022. The Falcons won the first meeting between the teams, 41-0 in San Diego in 1973. Stats and stuff Each team has built its record on success against the soft NFC South. Atlanta is 4-1 against division rivals. Los Angeles is 2-0 against the NFC South this season. The Chargers have a four-game winning streak against the division. ... Atlanta is 0-2 against AFC West teams, following a 22-17 loss to Kansas City and the lopsided loss at Denver. The Falcons will complete their tour of the AFC West with a game at the Las Vegas Raiders on Dec. 16. ... The Falcons are the league's only first-place team with a negative points differential. Atlanta has been outscored 274-244. Fantasy tip The loss of Dobbins, who has rushed for eight touchdowns, could put more pressure on QB Justin Hebert and the passing game. Herbert's favorite option has been WR Ladd McConkey, who has four TD receptions among his 49 catches for 698 yards. McConkey, the former University of Georgia standout who was drafted in the second round, could enjoy a productive return to the state against a Falcons defense that ranks only 26th against the pass. ___ AP NFL: https://apnews.com/hub/nfl The Associated Press

Tests keep coming for Auburn and Duke, who collide at Cameron Indoor Stadium in a typical prove-it game in a rare environment on Wednesday night. No. 2 Auburn and No. 9 Duke square off less than one month into the season as two of the most battle-tested teams in basketball. They're matched as one of the marquee games in the crossover showcase known as the ACC-SEC Challenge. Auburn (7-0) jumped two spots in the latest Top 25 poll propelled by its Maui Invitational championship. In one of Feast Week's toughest brackets, the Tigers rallied from 18 points down to beat then-No. 4 Iowa State, handled then-No. 12 North Carolina 85-72 and rolled past Memphis 90-76 in the title game. With a week off to shed any remnants of jet lag returning from the islands, Auburn head coach Bruce Pearl is pointing to another potential resume-building win. "The confidence that we're going to get from (Maui) is that we know we can play with anybody," Pearl said. "I promise you this, we'll stay humble and hungry. We will not begin to think too much of ourselves." Helping lead Auburn in Maui was fifth-year power forward Johni Broome. The tournament's MVP, Broome averaged 21.7 points, 15 rebounds, 4.3 assists and three blocks in the three-game sweep. Spearheading a veteran Tigers roster, Broome couldn't care less about individual honors. "I wanted to come to a place where the foundation was already built, and that's why I came to Auburn," Broome said. "Winning player of the year doesn't matter to me. I care about winning games, and making sure I can help my team in any way." Broome's 20.7 points and 12.9 rebounds per game lead the Tigers, while Chad Baker-Mazara adds 12.6 ppg and Denver Jones chips in 11.1. Auburn's next roadblock is earning its first-ever win against Duke. The Tigers are 0-3 all-time against the Blue Devils, including a six-point loss in the 2018 Maui Invitational. Duke (5-2) has already been through three games against ranked opponents. The Blue Devils had a 77-72 loss against then-No. 19 Kentucky, a 14-point win at then-No. 17 Arizona and a 75-72 defeat against No. 1 Kansas last week in Las Vegas. "Best team we've played so far," Pearl said of Duke. Bouncing back on Friday, the Blue Devils took down Seattle 70-48, holding the Redhawks to just 10 made field goals on 47 attempts (21.3 percent). Despite the suffocating defensive effort, Duke head coach Jon Scheyer knows his team has a long way to go. "I wasn't really happy with much tonight, to be honest," Scheyer said on Friday. "I thought we rushed some shots, had too many turnovers. We need to finish stronger, drive stronger, make extra passes, there were a whole bunch of things. ... We just need to get back to practice. In fairness to our guys, we've been traveling a lot and we just need practice time." Pacing the Blue Devils in scoring is five-star freshman Cooper Flagg. He's averaging 15.9 points per game to go along with 8.3 rebounds. Fellow freshman Kon Knueppel adds 13.4 points per contest. Far less seasoned raw freshman, big man Khaman Maluach has given Duke's interior defense an edge it was lacking last season. A projected lottery pick who can be overshadowed by the Flagg publicity train, Maluach (7-2, 248) is averaging 8.4 points, 5.0 rebounds and has two three-block games. In last year's inaugural ACC-SEC Challenge, Duke lost at Arkansas 80-75 and Auburn topped Virginia Tech 74-57. --Field Level Media

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Referee David Coote will not appeal against termination of contract

A special panel has given Democratic Gov. Katie Hobbs five choices from which she must pick the next justice of the Arizona Supreme Court. The list approved late Monday by the Commission on Appellate Court Appointments includes three Democrats and two political independents. That particular mix is not unusual. In fact, it's mandated by the Arizona Constitution, which requires the commission to provide a politically diverse list. No more than 60% can be from the same party. The commission clearly has a favorite: Maria Elena Cruz, currently a judge on the state Court of Appeals. The Yuma Democrat previously served as a judge for the Cocopah Indian Tribe and Yuma County Superior Court. She was the only one of the applicants who gained unanimous support of the 15 commissioners who voted; Chief Justice Ann Scott Timmer, who chairs the panel, chose to abstain in all cases. Racial/ethnic information is required to be included in each application; Cruz identifies as a Black Latina. Women have been represented on the court for decades. But there were no Hispanics on the court until 2016 when then-Gov. Doug Ducey named John Lopez to the court. There have been no Black justices. Nicole Davis, who is deputy director of the Department of Economic Security and the agency's general counsel, picked up 13 votes from the commissioners. She is a political independent and is Black. Prior to working at DES, she was a deputy general counsel for the Arizona Health Care Cost Containment System, the state's Medicaid program. She also served as deputy general counsel to Democrat Janet Napolitano when she was governor. Also on the list is Andrew Jacobs, a Democrat who is white. Most of his experience before joining the court was in private practice at a Phoenix law firm. He got 12 votes. Picking up 14 votes was Regina Nassen, principal assistant attorney for the city of Tucson. Initially a political independent, she registered as a Democrat for 14 years before becoming an independent again in 2014. Nassen, who is white, also has experience in private practice. The list is filled out by Alexander Samuels, an assistant state attorney general who is a Democrat, is white, and previously worked as an assistant U.S. attorney. Hobbs has 60 days to make her pick to replace retiring Justice Robert Brutinel, a Republican. Her choice will be final, with no requirement for Senate confirmation. Hers will be the first pick by a Democratic governor in nearly two decades. Everyone now on the court was named either by Jan Brewer or Ducey, both of whom are Republicans. They chose only Republicans with the exception of Ducey's pick of Clint Bolick, who was registered as a political independent when named. Get your morning recap of today's local news and read the full stories here: tucne.ws/morning Howard Fischer is a veteran journalist who has been reporting since 1970 and covering state politics and the Legislature since 1982. Follow him on X, formerly known as Twitter, Bluesky , and Threads at @azcapmedia or email azcapmedia@gmail.com . Respond: Write a letter to the editor | Write a guest opinion Subscribe to stay connected to Tucson. A subscription helps you access more of the local stories that keep you connected to the community. Get Government & Politics updates in your inbox! Stay up-to-date on the latest in local and national government and political topics with our newsletter.Kosovo arrests blast suspects, Serbia denies involvement

WINSTON-SALEM, N.C. (AP) — It wasn’t how Duke drew up the final play, but it worked out perfect for the Blue Devils in Saturday’s 23-17 victory over Wake Forest. Maalik Murphy threw a 39-yard touchdown pass to Jordan Moore as time expired, allowing Duke to end the regular season with three consecutive victories. Murphy said he realized he took too long to make a decision after the last snap. “I knew at that point I had to make a play,” he said. “The damage was already done, time was ticking.” With the score tied at 17, the Blue Devils (9-3, 5-3 Atlantic Coast Conference) moved 76 yards in 1:22 after forcing a Wake Forest punt. It appeared that Duke might run out of time in the slow-developing play, but Moore improvised and broke free along the right side, caught the ball at the 10-yard line and spun into the end zone to complete a comeback from 14 points down in the second half. “The play that Maalik and Jordan put together was magical,” Duke coach Manny Diaz said. “Nobody thought a 5-yard route would turn into a (long) touchdown.” So instead of a long field-goal attempt, Duke had something better. “I just decided to take it down the field,” Moore said. “I think that’s a testament to our chemistry. ... Maalik had the confidence in himself to make that kind of play.” It resulted in Duke’s sixth victory by seven points or less. “It’s like a perfect exclamation point to our season,” Diaz said. “An unbelievable way to finish our season.” Murphy racked up with 235 yards on 26-for-34 passing. Moore, who was down with an injury after a reception earlier in the second half, made five catches for 98 yards. Hank Bachmeier threw for 207 yards and a touchdown as Wake Forest (4-8, 2-6) ended its second straight four-win season with a four-game losing streak. “A heartbreaking loss,” Demon Deacons coach Dave Clawson said. “It’s a tough way to lose a game and a tough way to end the season.” Tate Carey’s 8-yard run, Matthew Dennis’ 37-yard field goal and Horatio Fields’ 9-yard reception across 11 minutes of game time gave Wake Forest a 17-3 lead with nine minutes left in the third quarter. Duke took advantage of a short field following a punt, moving 42 yards in four plays to score on Star Thomas’ 3-yard run. The Blue Devils recovered a fumble on the ensuing kickoff and converted on Murphy’s 2-yard run with 12:57 left to pull even. “What has been proven is that we’re mentally tough,” Diaz said. “We’re not going to do everything perfect.” Record receiver Taylor Morin became Wake Forest’s all-time leader in receiving yards with 2,974. He picked up 47 yards on eight catches on Saturday. Morin, in his fifth season, passed former NFL player Ricky Proehl, who had 2,929 yards in the late 1980s. The takeaway Duke: The Blue Devils have secured at least a nine-win season for the second time in three seasons, this one coming in Diaz’s first season. They racked up a 4-0 record against in-state opponents, including comebacks to top North Carolina and Wake Forest. “Every quest that we have for championships starts in our own state,” Diaz said. Wake Forest: The Demon Deacons punted on their final three possessions of the season. They finished with a 1-6 record in home games. “It’s been a tough year, a long year, and I’m proud of our team and how hard they fought,” Clawson said. Up next Duke: Awaits a bowl invitation Wake Forest: Enters the offseason with a losing record for the third time in five seasons. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football

Mariah Carey sparks romance rumors with Anderson .Paak as they hold hands entering Aspen restaurant Have YOU got a story? Email tips@dailymail.com By CHRISTINE RENDON FOR DAILYMAIL.COM Published: 23:10, 23 December 2024 | Updated: 23:22, 23 December 2024 e-mail View comments Mariah Carey and Anderson .Paak raised eyebrows as they were seen enjoying dinner together in Aspen. In photos obtained by TMZ , the Leave The Door open singer, 38, sweetly held her hand as they entered Catch Steak restaurant on Sunday evening. He even gently had his hand wrapped her around her waist as they ducked into the eatery and, ever the gentleman, appeared to hold the door open for her. While the duo's display may have suggested they were an item, sources insisted to TMZ the two are not dating, and the musicians were even observed leaving the restaurant separately. Mariah, 55, and Anderson are currently collaborating on a new musical project, and the duo have been hitting up a recording studio in Aspen as of late, according to insiders. On Thursday, the duo were reportedly enjoying a dinner break from all their hard work at Catch. Mariah Carey raised eyebrows as she was seen entering an Aspen restaurant hand in hand with fellow musician Anderson .Paak Anderson has been giving social media followers a sneak peak of their musical collaboration, and over the summer shared video of him and Mariah at the legendary Electric Lady music studios in the Big Apple. Narrating the video, Anderson told fans: 'Oh my God Mariah Carey. Listen, you ever be star-struck, like when a star strikes you? That's what it was. But I couldn't just freeze up. We had to get into the studio and just make something.' Read More Anderson .Paak files for divorce from wife Jae Lin Anderson linked up with Mariah again this past Halloween - he shared a snap of himself dressed as a member of Daft Punk as he celebrated the holiday alongside Carey. Mariah was last in a long-term relationship with back-up dancer Bryan Tanaka however they went their separate ways last year, while in January Anderson filed for divorce from Jae Lin after more than 10 years of marriage. Anderson shares two sons with Jae, his second wife - Soul and Shine. The singer recently released his directorial debut, K-Pops!, which starred himself and his eldest son. The feature was inspired by what the singer, who is of mixed Black and Korean heritage, described as 'funnier aspects of the experience' of growing up biracial. The performer previously spoke to Hypebeast about why he chose to cast Soul in the feature. Anderson has been giving social media followers a sneak peak of their musical collaboration, and over the summer shared video of him and Mariah at the legendary Electric Lady music studios in the Big Apple Anderson linked up with Mariah again this past Halloween - he shared a snap of himself dressed as Daft Punk as he celebrated the holiday alongside Carey 'I wanted to write a movie that would explore that dynamic and those familial relationships. And also, I get to sneak in quality time with my son while shooting,' he said. Meanwhile, the 'Queen of Christmas' has been spending the last few days in snowy Aspen after wrapping her Christmas Time Tour. The tour was announced in August and it celebrated the 30th anniversary of her timeless holiday hit, All I Want For Christmas Is You. The first show was on November 6 in Highland, California, and the closing concert was December 17 in Brooklyn. Meanwhile, the 'Queen of Christmas' has been spending the last few days in snowy Aspen after wrapping her Christmas Time Tour Mariah's setlist was rounded out with 26 songs and the concert was around 90 minutes-long. Audiences enjoyed renditions of the superstar's biggest, most recognizable songs as well as holiday classics. It's become customary for Carey to promote her mid-90s Christmas album during the last two months of the year. The lead single is ubiquitous around the holiday season as fans annually push it back to the top of the music charts. Mariah Carey Share or comment on this article: Mariah Carey sparks romance rumors with Anderson .Paak as they hold hands entering Aspen restaurant e-mail Add commentHONEYWELL AND BOMBARDIER SIGN LANDMARK AGREEMENT TO DELIVER THE NEXT GENERATION OF AVIATION TECHNOLOGY; HONEYWELL UPDATES 2024 OUTLOOKDuke rallies from 14 down, beats Wake Forest 23-17 on final-play passALTOONA, Pa. — The man accused of killing UnitedHealthcare’s CEO struggled with deputies and shouted while being led into court Tuesday as new details emerged about his possible motivation behind the ambush. In his first public words since a five-day search ended with his arrest at a McDonald’s in Pennsylvania, Luigi Nicholas Mangione emerged from a patrol car shouting about an “insult to the intelligence of the American people” while deputies pushed him inside a courthouse. The 26-year-old Ivy League graduate from a prominent Maryland real estate family is fighting attempts to extradite him to New York to face a murder charge in the Manhattan killing of Brian Thompson, who led the United States’ largest medical insurance company. A law enforcement bulletin obtained by The Associated Press said that at the time of his arrest, Mangione carried a handwritten document expressing anger with what he called “parasitic” health insurance companies and a disdain for corporate greed and power. He wrote that the U.S. has the most expensive health care system in the world and that profits of major corporations continue to increase while “our life expectancy” does not, according to the bulletin. In social media posts, Mangione called “Unabomber” Ted Kaczynski — who carried out a series of bombings while railing against modern society and technology — a “political revolutionary,” according to the bulletin. Mangione remained jailed in Pennsylvania, where he was initially charged with possession of an unlicensed firearm, forgery and providing false identification to police. Manhattan prosecutors began to take steps to bring Mangione to New York, but at a brief hearing Tuesday, defense lawyer Thomas Dickey said his client will not waive extradition and instead wants a hearing on the issue. Mangione was denied bail after prosecutors said he was too dangerous to be released. “You can’t rush to judgment in this case or any case,” Dickey said afterward. “He’s presumed innocent. Let’s not forget that.” New York Gov. Kathy Hochul said Tuesday night on the social platform X that she will sign “a request for a governor’s warrant to ensure the suspect in the murder of Brian Thompson is held accountable in New York.” Mangione was arrested in Altoona, Pennsylvania, about 230 miles west of New York City, after a McDonald’s customer recognized him and notified an employee, authorities said. An image of Mangione released Tuesday by Pennsylvania State Police showed him pulling down his mask in the corner of the McDonald’s while holding what appeared to be hash browns and wearing a winter jacket and beanie. New York police officials said Mangione was carrying a gun like the one used to kill Thompson and the same fake ID the shooter had used to check into a New York hostel, along with a passport and other fraudulent IDs. A law enforcement official who spoke with The Associated Press on condition of anonymity said a handwritten document found with Mangione included a line in which he claimed to have acted alone. “To the Feds, I’ll keep this short, because I do respect what you do for our country. To save you a lengthy investigation, I state plainly that I wasn’t working with anyone,” the document said, according to the official. It also said, “I do apologize for any strife or traumas but it had to be done. Frankly, these parasites simply had it coming.” Thompson, 50, was killed last Wednesday as he walked alone to a Manhattan hotel for an investor conference. From surveillance video, New York investigators determined the shooter quickly fled the city, likely by bus. Mangione was born into a life of country clubs and privilege. His grandfather was a real estate developer and philanthropist. Valedictorian at his elite Baltimore prep school, he went on to earn undergraduate and graduate degrees in computer science in 2020 from the University of Pennsylvania, a spokesperson said. “Our family is shocked and devastated by Luigi’s arrest,” Mangione’s family said in a statement posted on social media late Monday by his cousin, Maryland Del. Nino Mangione. “We offer our prayers to the family of Brian Thompson and we ask people to pray for all involved.” From January to June 2022, Luigi Mangione lived at Surfbreak, a “co-living” space at the edge of touristy Waikiki in Honolulu. Like other residents of the shared penthouse catering to remote workers, Mangione underwent a background check, said Josiah Ryan, a spokesperson for owner and founder R.J. Martin. “Luigi was just widely considered to be a great guy. There were no complaints,” Ryan said. “There was no sign that might point to these alleged crimes they’re saying he committed.” At Surfbreak, Martin learned Mangione had severe back pain from childhood that interfered with many aspects of his life, from surfing to romance, Ryan said. Mangione left Surfbreak to get surgery on the mainland, Ryan said, then later returned to Honolulu and rented an apartment. Martin stopped hearing from Mangione six months to a year ago. Mangione Mangione Get local news delivered to your inbox!

Biden says Trump economic plan will be 'disaster'David Coote will not appeal against the termination of his contract by referees’ body PGMOL, the PA news agency understands. Coote was sacked earlier this month after the emergence of a video in which he made derogatory remarks about Liverpool and their former manager Jurgen Klopp. Professional Game Match Officials Limited (PGMOL) said that a thorough investigation had concluded he was “in serious breach of the provisions of his employment contract, with his position deemed untenable”. “Supporting David Coote continues to be important to us and we remain committed to his welfare,” PGMOL’s statement on December 9 added. Coote had the right to appeal against the decision but PA understands the Nottinghamshire referee has decided not to. The video which triggered PGMOL’s investigation into Coote’s conduct first came to public attention on November 11. In it, Coote is asked for his views on a Liverpool match where he has just been fourth official, and describes them as “s***”. He then describes Klopp as a “c***”, and, asked why he felt that way, Coote says the German had “a right pop at me when I reffed them against Burnley in lockdown” and had accused him of lying. “I have got no interest in speaking to someone who’s f****** arrogant, so I do my best not to speak to him,” Coote said. Later in the video, Coote again refers to Klopp, this time as a “German c***”. The Football Association opened its own investigation into that video, understood to be centred on that last comment and whether Coote’s reference to Klopp’s nationality constituted an aggravated breach of its misconduct rules. The investigation by PGMOL which led to Coote’s contract being terminated is also understood to have looked at another video which appeared to show Coote snorting a white powder, purportedly during Euro 2024 where he was one of the assistant VARs for the tournament. European football’s governing body UEFA also appointed an ethics investigator to look into the matter.

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