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epic game store Lesabelimab is under clinical development by Dragonboat Biopharmaceutical (Shanghai) and currently in Phase I for Endometrial Cancer. According to GlobalData, Phase I drugs for Endometrial Cancer have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Lesabelimab overview lesabelimab is under development for the treatment of advanced malignant tumors including invasive bladder cancer, head and neck squamous cell carcinoma, esophageal squamous cell carcinoma and penile squamous cell carcinoma, endometrial cancer, cervical cancer, ovarian cancer, colorectal cancer, advanced non-clear cell renal cancer and advanced penile cancer, and unspecified indication. It acts by targeting PD L1. The drug candidate is administered as injection. lesabelimab is under development for the treatment of nasopharyngeal carcinoma and solid tumors. Dragonboat Biopharmaceutical (Shanghai) overview Dragonboat Biopharmaceutical (Shanghai) (Dragonboat Biopharmaceutical), a subsidiary of Guilin Sanjin Pharmaceutical Co Ltd, is a biopharmaceutical company that researches and develops biologics for cancers and autoimmune diseases. The company pipeline product includes BC003, BC001, BC005, BC006, BC007, BC008, BC010, BC011 and BCT2101. Dragonboat Biopharmaceutical drug candidate indications include solid tumors, tenosynovial giant cell tumors, asthma, gastric cancer and pancreatic cancer among others. It also utilizes an In-house systemic platform. The company operates a drug research and development center that covers early discovery, preclinical research, IND, clinical research, biologics license application and manufacturing. Dragonboat Biopharmaceutical is headquartered in Shanghai, China. For a complete picture of Lesabelimab’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Euro plunges to its lowest for two years Purchasing managers' index at 48.1 in November, down from 50 in September Data sent euro plunging to just above $1.03 versus the dollar This is its lowest since November 2022 By JOHN-PAUL FORD ROJAS Updated: 21:50 GMT, 22 November 2024 e-mail 6 View comments The euro sank to a two-year low against the dollar yesterday as political turmoil in Germany and France dragged the single currency zone's economy into reverse. A closely-watched monthly survey of business activity fell unexpectedly to 48.1 in November, down from 50 in September – on an index where the 50 mark separates growth from contraction. The purchasing managers' index (PMI) data sent the euro plunging to just above $1.03 versus the US currency, its lowest since November 2022. Yields on eurozone government bonds also fell as investors bet on faster interest rate cuts. The European Central Bank has cut rates three times this year to 3.25 per cent amid deepening concerns about lacklustre growth. Markets expect another quarter-point cut next month followed by further reductions taking the rate to 1.75 per cent by the end of 2025. Jane Foley, senior FX strategist at Rabobank, said the euro had taken 'a step closer to parity' with the dollar. Struggle: The purchasing managers' index data sent the euro plunging to just above $1.03 versus the US currency, its lowest since November 2022 However, it was little changed versus the pound, after PMI data for the UK also proved dismal as Labour's tax raid on employers in the Budget took its toll. Sterling was trading at just over €1.20. The eurozone PMI figures showed the services sector going into reverse for the first time in ten months and the decline in the manufacturing sector deepening. Germany, Europe's biggest economy, is in limbo after its coalition government collapsed this month – and elections are not due until February. Meanwhile, revised figures yesterday downgraded third-quarter growth from 0.2 per cent to 0.1 per cent. The country, once a manufacturing powerhouse, is in crisis as demand from China slumps and its vast car industry grapples with the transition to electric vehicles. RELATED ARTICLES Previous 1 Next Brussels warning to White House over 'harmful' tariffs Artificial intelligence to replace workers after Budget,... Share this article Share HOW THIS IS MONEY CAN HELP How to choose the best (and cheapest) stocks and shares Isa and the right DIY investing account Bosch became the latest industrial giant to be hit yesterday, announcing 3,500 job cuts, affecting the part of the company that develops technology for vehicles. US car maker Ford is also cutting thousands of jobs in Germany while Volkswagen, Europe's biggest car maker, is expected to close as many as three factories. In France, hard-Right legislators are threatening to topple prime minister Michel Barnier's fragile coalition in a dispute about the 2025 budget. Adding to the gloom is the fear that Donald Trump's threatened trade tariffs will hurt the European economy. Cyrus de la Rubia, chief economist at Hamburg Commercial Bank, which compiled the PMI figures, said: 'Things could hardly have turned out much worse. The manufacturing sector is sinking deeper into recession, and now the services sector is starting to struggle after two months of marginal growth. 'It is no surprise, given the political mess in the biggest eurozone economies lately. 'France's government is on shaky ground and Germany's heading for early elections. Throw in the election of Donald Trump and it is no wonder the economy is facing challenges.' Bert Colijn, chief economist at ING Bank, said 'The November PMI is another wake-up call for eurozone policymakers that the economy continues to show signs of weakness. 'New business is weakening again for manufacturing and services with export orders in particular being down sharply as the eurozone economy battles weak demand from abroad.' 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TEL AVIV, Israel (AP) — Israeli Prime Minister Benjamin Netanyahu underwent successful surgery Sunday to have his prostate removed, hospital officials said, a procedure that came as he manages multiple crises including the war in Gaza and his trial for alleged corruption . Netanyahu, who has had a series of health issues in recent years, has gone to great lengths to bolster a public image of himself as a healthy, energetic leader. During his trial this month, he boasted about working 18-hour days, accompanied by a cigar. But as Israel's longest-serving leader, such a grueling workload over a total of 17 years in power could take a toll on his well-being. Netanyahu, 75, is among older world leaders including U.S. President Joe Biden, 82 , President-elect Donald Trump, 78 , Brazil's President Luiz Inácio Lula da Silva , 79, and Pope Francis , 88, who have come under scrutiny for their age and health issues. Netanyahu's latest condition is common in older men, but the procedure has had some fallout. The judges overseeing his trial accepted a request from his lawyer on Sunday to call off three days of testimony scheduled this week. The lawyer, Amit Hadad, had argued that Netanyahu would be fully sedated for the procedure and hospitalized for “a number of days.” Dr. Ofer Gofrit, head of the urology department at Jerusalem's Hadassah Medical Center, said in a video statement late Sunday that the procedure had gone well and “there was no fear” of cancer or malignancy. “We only hope for the best,” he said. In a statement, Netanyahu thanked his doctors. His office said he was "fully alert" and was taken to an underground recovery unit fortified against potential missile attacks. Netanyahu was expected to remain in the hospital for several days of observation. Justice Minister Yariv Levin, a close ally, served as acting prime minister during the operation. With so much at stake, Netanyahu’s health in wartime is a concern for both Israelis and the wider world. As Israel’s leader, Netanyahu is at the center of major global events that are shifting the Middle East . With the dizzying pace of the past 14 months, being incapacitated for even a few hours can be risky. Netanyahu will be in the hospital at a time when international mediators are pushing Israel and Hamas to reach a ceasefire in Gaza and as fighting between Israel and Yemen’s Iran-backed Houthi rebels intensifies . Prostate issues are common and in many cases easily treatable. Still, the procedure puts a dent in Netanyahu’s image of vigor at a time when he would want to project strength more than ever, both to an Israeli audience navigating constant threats as well as to Israel’s enemies looking to expose its weaknesses. Netanyahu insists he is in excellent health. His office releases footage of him touring war zones in full protective gear flanked by military officers, or meeting with defense officials on windswept hilltops in youthful dark shades and puffer jackets. But that image was shattered last year when Netanyahu’s doctors revealed that he had a heart condition , a problem that he had apparently long known about but concealed from the public. A week after a fainting spell, Netanyahu was fitted with a pacemaker to control his heartbeat. Only then did staff at the Sheba Medical Center reveal that Netanyahu has for years experienced a condition that can cause irregular heartbeats. The revelation came as Netanyahu was dealing with massive anti-government protests. The news about a chronic heart problem stoked further anger and distrust during extreme political polarization in Israel. Last year, Netanyahu was rushed to the hospital for what doctors said likely was dehydration . He stayed overnight, prompting his weekly Cabinet meeting to be delayed. Earlier this year, Netanyahu underwent hernia surgery , during which he was under full anesthesia and unconscious. Levin served as acting prime minister during the operation. According to Netanyahu’s office, the Israeli leader was diagnosed with a urinary tract infection on Wednesday stemming from a benign enlargement of his prostate. The infection was treated successfully with antibiotics, but doctors said the surgery was needed in any case. Complications from prostate enlargement are common in men in their 70s and 80s, Dr. Shay Golan, head of the oncology urology service at Israel’s Rabin Medical Center, told Israeli Army Radio. Golan spoke in general terms and was not involved in Netanyahu’s care or treatment. He said an enlarged prostate can block proper emptying of the bladder, leading to a build-up of urine that can lead to an infection or other complications. After medicinal treatment, doctors can recommend a procedure to remove the prostate to prevent future blockages, Golan said. In Netanyahu’s case, because the prostate is not cancerous, Golan said doctors were likely performing an endoscopic surgery, carried out by inserting small instruments into a body cavity, rather than making surgical cuts in the abdomen to reach the prostate. The procedure lasts about an hour, Golan said, and recovery is quick. He said that aside from catheter use for one to three days after the procedure, patients can return to normal activity without significant limitations. AP correspondent Isaac Scharf contributed reporting.

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The Ultimate Upgrade: Slice Master Reimagined on Slicemaster.netRuud van Nistelrooy has made history by becoming the first manager to defeat a team twice and then go on to manage them in the same season, following his debut as Leicester City's manager. The Dutchman, who was recently let go by Manchester United, is now at the helm of the Foxes, aiming to guide them away from the relegation zone. Van Nistelrooy initially joined as Erik ten Hag's assistant in the summer, but took over temporarily when Ten Hag was dismissed. During his four-match stint, he led the team to victory against Leicester twice - once in the Carabao Cup and once in the Premier League. Despite being moved on by Manchester United following Ruben Amorim's arrival, Van Nistelrooy quickly found a new role at the King Power Stadium, making Premier League history in the process. His first game in charge saw Leicester triumph 3-1 over West Ham on Tuesday night, marking their third win of the Premier League season and the beginning of a new era. Jamie Vardy opened the scoring after a VAR check, with Bilal El Khannouss and Patson Daka adding to the tally in the second half. Niclas Fullkrug managed to score for the visitors, but it was too little, too late. The Dutch legend Ruud van Nistelrooy, who once held a record in the Premier League for scoring in ten consecutive league games, has now joined forces with the man who surpassed his achievement, Jamie Vardy at Leicester. Van Nistelrooy's record was eclipsed by Vardy during the Foxes' fairy-tale 2015/16 season when he found the net in 11 successive matches, reports the Mirror . At his unveiling, Van Nistelrooy humorously addressed the topic, saying with a grin: "It's a problem he broke my record, I said to him we have a big issue to get out of the way! At the time I made a tweet about breaking the record and wishing him well. Nine years later it's weird how these things go, but good stories." He added praise for Vardy's longevity and performance: "He is someone who has had a career for a long time and has been performing all these seasons. He still is and he's a great striker and great to have him in the squad."

KYIV, Ukraine (AP) — NATO and Ukraine will hold emergency talks Tuesday after Russia attacked a central city with an experimental, hypersonic ballistic missile that escalated the nearly 33-month-old war. The conflict is “entering a decisive phase,” Poland’s Prime Minister Donald Tusk said Friday, and “taking on very dramatic dimensions.” Ukraine’s parliament canceled a session as security was tightened following Thursday’s Russian strike on a military facility in the city of Dnipro. In a stark warning to the West, President Vladimir Putin said in a nationally televised speech that the attack with the intermediate-range Oreshnik missile was in retaliation for Kyiv’s use of U.S. and British longer-range missiles capable of striking deeper into Russian territory. Putin said Western air defense systems would be powerless to stop the new missile. Ukrainian military officials said the missile that hit Dnipro had reached a speed of Mach 11 and carried six nonnuclear warheads each releasing six submunitions. Speaking Friday to military and weapons industries officials, Putin said Russia is launching production of the Oreshnik. “No one in the world has such weapons,” he said with a thin smile. “Sooner or later other leading countries will also get them. We are aware that they are under development.” But he added, “we have this system now. And this is important. Testing the missile will continue, “including in combat, depending on the situation and the character of security threats created for Russia,” Putin said. noting there is ”a stockpile of such systems ready for use.” Putin said that while it isn’t an intercontinental missile, it’s so powerful that the use of several of them fitted with conventional warheads in one attack could be as devastating as a strike with strategic — or nuclear — weapons. Gen. Sergei Karakayev, head of Russia’s Strategic Missile Forces, said the Oreshnik could reach targets across Europe and be fitted with nuclear or conventional warheads, echoing Putin’s claim that even with conventional warheads, “the massive use of the weapon would be comparable in effect to the use of nuclear weapons.” Kremlin spokesman Dmitry Peskov kept up Russia’s bellicose tone on Friday, blaming “the reckless decisions and actions of Western countries” in supplying weapons to Ukraine to strike Russia. “The Russian side has clearly demonstrated its capabilities, and the contours of further retaliatory actions in the event that our concerns were not taken into account have also been quite clearly outlined,” he said. Hungarian Prime Minister Viktor Orbán, widely seen as having the warmest relations with the Kremlin in the European Union, echoed Moscow’s talking points, suggesting the use of U.S.-supplied weapons in Ukraine likely requires direct American involvement. “These are rockets that are fired and then guided to a target via an electronic system, which requires the world’s most advanced technology and satellite communications capability,” Orbán said on state radio. “There is a strong assumption ... that these missiles cannot be guided without the assistance of American personnel.” Orbán cautioned against underestimating Russia’s responses, emphasizing that the country’s recent modifications to its nuclear deployment doctrine should not be dismissed as a “bluff.” “It’s not a trick... there will be consequences,” he said. Separately in Kyiv, Czech Foreign Minister Jan Lipavský called Thursday’s missile strike an “escalatory step and an attempt of the Russian dictator to scare the population of Ukraine and to scare the population of Europe.” At a news conference with Ukrainian Foreign Minister Andrii Sybiha, Lipavský also expressed his full support for delivering the necessary additional air defense systems to protect Ukrainian civilians from the “heinous attacks.” He underlined that the Czech Republic will impose no limits on the use of its weapons and equipment given to Ukraine. Three lawmakers from Ukraine’s parliament, the Verkhovna Rada, confirmed that Friday’s previously scheduled session was called off due to the ongoing threat of Russian missiles targeting government buildings in central Kyiv. In addition, there also was a recommendation to limit the work of all commercial offices and nongovernmental organizations “in that perimeter, and local residents were warned of the increased threat,” said lawmaker Mykyta Poturaiev, who added this is not the first time such a threat has been received. President Volodymyr Zelenskyy’s office continued to work in compliance with standard security measures, a spokesperson said. Ukraine’s Main Intelligence Directorate said the Oreshnik missile, whose name in Russian means “hazelnut tree,” was fired from the Kapustin Yar 4th Missile Test Range in Russia’s Astrakhan region, and flew 15 minutes before striking Dnipro. Test launches of a similar missile were conducted in October 2023 and June 2024, the directorate said. The Pentagon confirmed the missile was a new, experimental type of intermediate-range missile based on its RS-26 Rubezh intercontinental ballistic missile. Thursday’s attack struck the Pivdenmash plant that built ICBMs when Ukraine was part of the Soviet Union. The military facility is located about 4 miles (6 1/2 kilometers) southwest of the center of Dnipro, a city of about 1 million that is Ukraine’s fourth-largest and a key hub for military supplies and humanitarian aid, and is home to one of the country’s largest hospitals for treating wounded soldiers from the front before their transfer to Kyiv or abroad. The stricken area was cordoned off and out of public view. With no fatalities reported from the attack, Dnipro residents resorted to dark humor on social media, mostly focused on the missile’s name, Oreshnik. Elsewhere in Ukraine, Russia struck a residential district of Sumy overnight with Iranian-designed Shahed drones, killing two people and injuring 13, the regional administration said.. Ukraine’s Suspilne media, quoting Sumy regional head Volodymyr Artiukh, said the drones were stuffed with shrapnel elements. “These weapons are used to destroy people, not to destroy objects,” said Artiukh, according to Suspilne. —— Associated Press journalists Lorne Cook in Brussels, Samya Kullab in Kyiv, Dasha Litvinova in Tallinn, Estonia, and Justin Spike in Budapest, Hungary, contributed. —— Follow AP’s coverage of the war in Ukraine at https://apnews.com/hub/russia-ukraineSpaDeX mission to help India ace space docking technology: ISROWestern Washington Medical Group Partners with Inventurus Knowledge Solutions Limited to Enhance Revenue Cycle Operations and Patient Access

Mumbai : Cooking enthusiasts and reality TV fans are in for a treat with the announcement of Celebrity MasterChef India, a spin-off of the popular MasterChef India series. Sony Entertainment Television confirmed the show on Saturday, sharing a promo video that has already created a buzz online. A post shared by Sony Entertainment Television (@sonytvofficial) The upcoming series will see eight well-known personalities from television and social media battle it out in the kitchen to prove their culinary prowess. The confirmed contestants are: Adding a fresh twist to the show, renowned choreographer and filmmaker Farah Khan will step in as the host for this season. Known for her quick wit and love for food, Farah’s lively personality is expected to add a unique charm to the show. The judging panel will feature the return of celebrated chefs Vikas Khanna and Ranveer Brar, who have been fan favorites in previous seasons. Their expertise, mentorship, and camaraderie will guide the contestants through challenges that test their creativity and culinary skills. Celebrity MasterChef India will air on Sony TV, with the premiere date expected to be announced soon. Fans of both cooking shows and celebrity reality TV can look forward to a season filled with drama, creativity, and delicious dishes. Stay tuned to Siasat.com for more updates on this exciting new show!